dE2F2, E2f
negatively regulates genes involved in the S (DNA synthesis) phase of the cell cycle - Retinoblastoma family 2 is required for the tissue-specific repression of dE2F2 target genes
Please see the JBrowse view of Dmel\E2f2 for information on other features
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Gene model reviewed during 5.46
Gene model reviewed during 5.56
1.4 (northern blot)
370 (aa); 41.4 (kD predicted)
Forms a heterodimer with Dp. Interacts with Rbf/Rbf1 and Rbf2. Component of the DREAM complex, which is at least composed of Myb, Caf1, mip40, mip120, mip130, E2f2, Dp, Rbf, Rbf2, lin-52, Rpd3 and l(3)mbt.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\E2f2 using the Feature Mapper tool.
Comment: maternally supplied
Comment: mitotically active cells
Comment: mitotically active cells
Comment: endoreplicating cells
Comment: maternally deposited
Comment: reported as ventral nerve cord anlage
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
E2f2 transcript is detected in all developmental stages, with highest levels in 4-8 hr embryos, and low levels in unfertilized eggs, larvae, pupae, and adults.
GBrowse - Visual display of RNA-Seq signals
View Dmel\E2f2 in GBrowse 22-54
2-54
2-54.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: E2f2 CG1071
E2f2 mutants are viable, but females are partially sterile. Mutant follicle cells terminate endocycles normally, but then fail to confine DNA synthesis to sites of gene amplification and inappropriately begin genomic DNA replication (this ectopic DNA synthesis is not a continuation of the endocycle program).