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Gene Dmel\Bin1

General Information
Symbol	Dmel\Bin1	Species	D. melanogaster
Name	Bicoid interacting protein 1	Annotation symbol	CG6046
Feature type	protein_coding_gene	FlyBase ID	FBgn0024491
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	dSAP18, SAP18
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	89B7-89B7	Sequence location	3R:12,011,880..12,012,615 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Bicoid interacting protein 1 is referred to in FlyBase by the symbol Dmel\Bin1 (CG6046, FBgn0024491). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; transcription factor binding; transcription corepressor activity. There is experimental evidence that it is involved in the biological process: chromatin silencing; negative regulation of transcription, DNA-dependent. 17 alleles are reported. The phenotype of these alleles is annotated with: adult abdominal segment 6. It has one annotated transcript and one annotated polypeptide. Protein features are: Histone deacetylase complex, SAP18 subunit; Sin3 associated polypeptide p18. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632565_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Bin1. Gene sequence location is 3R:12011880..12012615.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89B7-89B7   Limits computationally determined from genome sequence between P{PZ}blp01618 and P{PZ}gish04895&P{EP}EP3171
Experimentally Determined Cytological Location
Cytogenetic map Notes References 89B9-89B10   (determined by in situ hybridisation)   (Wang et al., 2002) 89B-89B   (determined by in situ hybridisation)   (Zhu et al., 2001) 89B9-89B10   Bin1 is located ~43 kb distal to Sb.   (Jones, 2000.3.9)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Bin1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Bin1-RA FBtr0083279  NM_079653   663   150
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Bin1-PA   FBpp0082731   17.3   150   8.48     NP_524377   AAF55284
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Sin3 associated polypeptide p18 (IPR010516) Histone deacetylase complex, SAP18 subunit (IPR017250)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55284   AF297546 AAG34996   AJ278500 CAB95728   AQ254719   AY070913 AAL48535   BF486394   BI163100   BI173127   BI215449   BI240903   BP540220   BP540221   BP550393   BP550394   BP557503   BP557504   BP558603   BT025229   CO191775   CO265233   CO281629   CO294631   CO339504   CZ487593   CZ487594   EC198851   EC199472   EC212954   EC215549   EC247281   EC258729   EV585717   FD585591   FD585608   FD585618   FD585917   FD585976   FD587559   GH739215   GH745164   GH756123   GH758576   GH775915   GH779327   GH779575   GH788260   GH789701   GH793513   GH793541   GH799762   GH804186   GH807818   GH815466   GH817030   GH826825   GH834213   GH835194   GH835241   GH837623   GH841930   GH844271   GH864170   GH864743   GH866914   GH870935   GH878239   GH883588   GH886727   GH888404   GH894703   GH905384   GH910466   GH916908   GH917700   GH919401   GH920881   GH923228   GH933645   GH935372   GH937207   GH938185
UniProtKB/Swiss-Prot	Q9VEX9
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 5   organism | ubiquitous & uniform   (Zhu et al., 2001) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 9   organism   (Zhu et al., 2001) Comment:0-4 hr AEL
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    728.675 Larval Midgut    96.7 Larval Hindgut    161.9 Larval Malpighian Tubules    130.3 Larval Fat Body    144.9 Larval Salivary Gland    282.1 Larval Trachea    299.575 Larval Carcass    188.8 Adult Head    123.8 Adult Eye    168.9 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    172.2 Adult Crop    141.3 Adult Midgut    128.4 Adult Hindgut    110.3 Adult Malpighian Tubules    63.5 Adult Fat Body    110 Adult Salivary Gland    119.7 Adult Heart    99.625 Adult VirginFemale Spermatheca    138.2 Adult InseminatedFemale Spermatheca    143.8 Adult Ovary    492.3 Adult Testis    60.4 Adult Male Accessory Gland    291.1 Adult Carcass    98 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (728.675) Larval Midgut    96.7 Larval Hindgut    161.9 Larval Malpighian Tubules    130.3 Larval Fat Body    144.9 Larval Salivary Gland    282.1 Larval Trachea    299.575 Larval Carcass    188.8 Adult Head    123.8 Adult Eye    168.9 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    172.2 Adult Crop    141.3 Adult Midgut    128.4 Adult Hindgut    110.3 Adult Malpighian Tubules    63.5 Adult Fat Body    110 Adult Salivary Gland    119.7 Adult Heart    99.625 Adult VirginFemale Spermatheca    138.2 Adult InseminatedFemale Spermatheca    143.8 Adult Ovary    492.3 Adult Testis    60.4 Adult Male Accessory Gland    291.1 Adult Carcass    98 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    728.675 Larval Midgut    96.7 Larval Hindgut    161.9 Larval Malpighian Tubules    130.3 Larval Fat Body    144.9 Larval Salivary Gland    282.1 Larval Trachea    299.575 Larval Carcass    188.8 Adult Head    123.8 Adult Eye    168.9 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    172.2 Adult Crop    141.3 Adult Midgut    128.4 Adult Hindgut    110.3 Adult Malpighian Tubules    63.5 Adult Fat Body    110 Adult Salivary Gland    119.7 Adult Heart    99.625 Adult VirginFemale Spermatheca    138.2 Adult InseminatedFemale Spermatheca    143.8 Adult Ovary    492.3 Adult Testis    60.4 Adult Male Accessory Gland    291.1 Adult Carcass    98 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    728.675 Larval Midgut    96.7 Larval Hindgut    161.9 Larval Malpighian Tubules    130.3 Larval Fat Body    144.9 Larval Salivary Gland    282.1 Larval Trachea    299.575 Larval Carcass    188.8 Adult Head    123.8 Adult Eye    168.9 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    172.2 Adult Crop    141.3 Adult Midgut    128.4 Adult Hindgut    110.3 Adult Malpighian Tubules    63.5 Adult Fat Body    110 Adult Salivary Gland    119.7 Adult Heart    99.625 Adult VirginFemale Spermatheca    138.2 Adult InseminatedFemale Spermatheca    143.8 Adult Ovary    492.3 Adult Testis    60.4 Adult Male Accessory Gland    291.1 Adult Carcass    98 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    728.675 Larval Midgut    96.7 Larval Hindgut    161.9 Larval Malpighian Tubules    130.3 Larval Fat Body    144.9 Larval Salivary Gland    282.1 Larval Trachea    299.575 Larval Carcass    188.8 Adult Head    123.8 Adult Eye    168.9 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    172.2 Adult Crop    141.3 Adult Midgut    128.4 Adult Hindgut    110.3 Adult Malpighian Tubules    63.5 Adult Fat Body    110 Adult Salivary Gland    119.7 Adult Heart    99.625 Adult VirginFemale Spermatheca    138.2 Adult InseminatedFemale Spermatheca    143.8 Adult Ovary    492.3 Adult Testis    60.4 Adult Male Accessory Gland    291.1 Adult Carcass    98 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  728.675 Larval Midgut    96.7 Larval Hindgut    161.9 Larval Malpighian Tubules    130.3 Larval Fat Body    144.9 Larval Salivary Gland    282.1 Larval Trachea    299.575 Larval Carcass    188.8 Adult Head    123.8 Adult Eye    168.9 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    172.2 Adult Crop    141.3 Adult Midgut    128.4 Adult Hindgut    110.3 Adult Malpighian Tubules    63.5 Adult Fat Body    110 Adult Salivary Gland    119.7 Adult Heart    99.625 Adult VirginFemale Spermatheca    138.2 Adult InseminatedFemale Spermatheca    143.8 Adult Ovary    492.3 Adult Testis    60.4 Adult Male Accessory Gland    291.1 Adult Carcass    98 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    728.675 Larval Midgut    96.7 Larval Hindgut    161.9 Larval Malpighian Tubules    130.3 Larval Fat Body    144.9 Larval Salivary Gland    282.1 Larval Trachea    299.575 Larval Carcass    188.8 Adult Head    123.8 Adult Eye    168.9 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    172.2 Adult Crop    141.3 Adult Midgut    128.4 Adult Hindgut    110.3 Adult Malpighian Tubules    63.5 Adult Fat Body    110 Adult Salivary Gland    119.7 Adult Heart    99.625 Adult VirginFemale Spermatheca    138.2 Adult InseminatedFemale Spermatheca    143.8 Adult Ovary    492.3 Adult Testis    60.4 Adult Male Accessory Gland    291.1 Adult Carcass    98 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    728.675 Larval Midgut    96.7 Larval Hindgut    161.9 Larval Malpighian Tubules    130.3 Larval Fat Body    144.9 Larval Salivary Gland    282.1 Larval Trachea    299.575 Larval Carcass    188.8 Adult Head    123.8 Adult Eye    168.9 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    172.2 Adult Crop    141.3 Adult Midgut    128.4 Adult Hindgut    110.3 Adult Malpighian Tubules    63.5 Adult Fat Body    110 Adult Salivary Gland    119.7 Adult Heart    99.625 Adult VirginFemale Spermatheca    138.2 Adult InseminatedFemale Spermatheca    143.8 Adult Ovary    492.3 Adult Testis    60.4 Adult Male Accessory Gland    291.1 Adult Carcass    98 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    123.8   NA  Eye    168.9   NA  Brain    172.1   728.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    172.2   NA  Crop    141.3   96.7  Midgut    128.4   161.9  Hindgut    110.3   130.3  Malpighian Tubules    63.5   144.9  Fat Body    110   282.1  Salivary Gland    119.7   NA  Heart    99.625   299.575  Trachea    NA   NA  VirginFemale Spermatheca    138.2   NA  InseminatedFemale Spermatheca    143.8   NA  Ovary    492.3   NA  Testis    60.4   NA  Male Accessory Gland    291.1   188.8  Carcass    98 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    34 central nervous system, pupae P8    13 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    6 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    32 carcass, larvae L3 wandering    18 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    33 ovary, mated 4-day female    26 testis, mated 4-day male    10 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3  (34) central nervous system, pupae P8    13 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    6 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8  (32) carcass, larvae L3 wandering    18 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female  (33) ovary, mated 4-day female  26 testis, mated 4-day male    10 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    34 central nervous system, pupae P8    13 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    6 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    32 carcass, larvae L3 wandering    18 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    33 ovary, mated 4-day female    26 testis, mated 4-day male    10 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    34 central nervous system, pupae P8    13 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    6 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    32 carcass, larvae L3 wandering    18 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    33 ovary, mated 4-day female    26 testis, mated 4-day male    10 accessory gland, mated 4-day male    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    34 central nervous system, pupae P8    13 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    6 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    32 carcass, larvae L3 wandering    18 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    33 ovary, mated 4-day female    26 testis, mated 4-day male    10 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3  (34) central nervous system, pupae P8    13 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    6 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8  32 carcass, larvae L3 wandering    18 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female  (33) ovary, mated 4-day female  26 testis, mated 4-day male    10 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    34 central nervous system, pupae P8    13 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    6 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    32 carcass, larvae L3 wandering    18 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    33 ovary, mated 4-day female    26 testis, mated 4-day male    10 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    34 central nervous system, pupae P8    13 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    6 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    32 carcass, larvae L3 wandering    18 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    33 ovary, mated 4-day female    26 testis, mated 4-day male    10 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    148 embryo 04-06hr    178 embryo 06-08hr    126 embryo 08-10hr    116 embryo 10-12hr    101 embryo 12-14hr    72 embryo 14-16hr    48 embryo 16-18hr    42 embryo 18-20hr    27 embryo 20-22hr    29 embryo 22-24hr    34 larva L1    20 larva L2    27 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    36 white prepupae new    41 white prepupae 12hr    45 white prepupae 24hr    61 pupae 2d postWPP    42 pupae 3d postWPP    20 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    11 adult female 01day    24 adult female 05day    40 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (81) embryo 02-04hr  (148) embryo 04-06hr  (178) embryo 06-08hr  (126) embryo 08-10hr  (116) embryo 10-12hr  (101) embryo 12-14hr  (72) embryo 14-16hr  (48) embryo 16-18hr  (42) embryo 18-20hr  (27) embryo 20-22hr  (29) embryo 22-24hr  (34) larva L1    20 larva L2  (27) larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6  (27) larva L3 puffstage 7-9  (36) white prepupae new  (41) white prepupae 12hr  (45) white prepupae 24hr  (61) pupae 2d postWPP  (42) pupae 3d postWPP    20 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    11 adult female 01day    24 adult female 05day  (40) adult female 30day  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr  (148) embryo 04-06hr  (178) embryo 06-08hr  (126) embryo 08-10hr  (116) embryo 10-12hr  101 embryo 12-14hr    72 embryo 14-16hr    48 embryo 16-18hr    42 embryo 18-20hr    27 embryo 20-22hr    29 embryo 22-24hr    34 larva L1    20 larva L2    27 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    36 white prepupae new    41 white prepupae 12hr    45 white prepupae 24hr    61 pupae 2d postWPP    42 pupae 3d postWPP    20 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    11 adult female 01day    24 adult female 05day    40 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    148 embryo 04-06hr    178 embryo 06-08hr    126 embryo 08-10hr    116 embryo 10-12hr    101 embryo 12-14hr    72 embryo 14-16hr    48 embryo 16-18hr    42 embryo 18-20hr    27 embryo 20-22hr    29 embryo 22-24hr    34 larva L1    20 larva L2    27 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    36 white prepupae new    41 white prepupae 12hr    45 white prepupae 24hr    61 pupae 2d postWPP    42 pupae 3d postWPP    20 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    11 adult female 01day    24 adult female 05day    40 adult female 30day    36 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    148 embryo 04-06hr    178 embryo 06-08hr    126 embryo 08-10hr    116 embryo 10-12hr    101 embryo 12-14hr    72 embryo 14-16hr    48 embryo 16-18hr    42 embryo 18-20hr    27 embryo 20-22hr    29 embryo 22-24hr    34 larva L1    20 larva L2    27 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    36 white prepupae new    41 white prepupae 12hr    45 white prepupae 24hr    61 pupae 2d postWPP    42 pupae 3d postWPP    20 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    11 adult female 01day    24 adult female 05day    40 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (81) embryo 02-04hr  (148) embryo 04-06hr  (178) embryo 06-08hr  (126) embryo 08-10hr  (116) embryo 10-12hr  (101) embryo 12-14hr  (72) embryo 14-16hr  (48) embryo 16-18hr  (42) embryo 18-20hr  27 embryo 20-22hr  29 embryo 22-24hr  (34) larva L1    20 larva L2  27 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6  27 larva L3 puffstage 7-9  (36) white prepupae new  (41) white prepupae 12hr  (45) white prepupae 24hr  (61) pupae 2d postWPP  (42) pupae 3d postWPP    20 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    11 adult female 01day    24 adult female 05day  (40) adult female 30day  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr  (148) embryo 04-06hr  (178) embryo 06-08hr  126 embryo 08-10hr  116 embryo 10-12hr  101 embryo 12-14hr    72 embryo 14-16hr    48 embryo 16-18hr    42 embryo 18-20hr    27 embryo 20-22hr    29 embryo 22-24hr    34 larva L1    20 larva L2    27 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    36 white prepupae new    41 white prepupae 12hr    45 white prepupae 24hr    61 pupae 2d postWPP    42 pupae 3d postWPP    20 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    11 adult female 01day    24 adult female 05day    40 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    148 embryo 04-06hr    178 embryo 06-08hr    126 embryo 08-10hr    116 embryo 10-12hr    101 embryo 12-14hr    72 embryo 14-16hr    48 embryo 16-18hr    42 embryo 18-20hr    27 embryo 20-22hr    29 embryo 22-24hr    34 larva L1    20 larva L2    27 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    36 white prepupae new    41 white prepupae 12hr    45 white prepupae 24hr    61 pupae 2d postWPP    42 pupae 3d postWPP    20 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    11 adult female 01day    24 adult female 05day    40 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    50 Schneider line 2 Sg4    40 embryonic 1182-4H    38 embryonic GM2    22 embryonic Kc167    26 embryonic S1    48 embryonic S3    26 leg disc CME L1    36 wing disc CME-W2    35 wing disc ML-DmD8    105 wing disc ML-DmD9    71 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    50 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    60 mixed discs ML-DmD4-c1    63 CNS ML-DmBG1-c1    72 CNS ML-DmBG2-c2    88 tumorous blood cells mbn2    28 ovary fGS/OSS    24 ovary OSC    21 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (50) Schneider line 2 Sg4  (40) embryonic 1182-4H  (38) embryonic GM2    22 embryonic Kc167  26 embryonic S1  (48) embryonic S3  26 leg disc CME L1  (36) wing disc CME-W2  (35) wing disc ML-DmD8  (105) wing disc ML-DmD9  (71) wing disc ML-DmD16-c3  (44) wing disc ML-DmD21  (50) wing disc ML-DmD32  (66) haltere disc ML-DmD17-c3  (38) eye-antennal disc ML-DmD11  (51) antennal disc ML-DmD20-c5  (60) mixed discs ML-DmD4-c1  (63) CNS ML-DmBG1-c1  (72) CNS ML-DmBG2-c2  (88) tumorous blood cells mbn2  (28) ovary fGS/OSS    24 ovary OSC    21 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    50 Schneider line 2 Sg4    40 embryonic 1182-4H    38 embryonic GM2    22 embryonic Kc167    26 embryonic S1    48 embryonic S3    26 leg disc CME L1    36 wing disc CME-W2    35 wing disc ML-DmD8  105 wing disc ML-DmD9    71 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    50 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    60 mixed discs ML-DmD4-c1    63 CNS ML-DmBG1-c1    72 CNS ML-DmBG2-c2    88 tumorous blood cells mbn2    28 ovary fGS/OSS    24 ovary OSC    21 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    50 Schneider line 2 Sg4    40 embryonic 1182-4H    38 embryonic GM2    22 embryonic Kc167    26 embryonic S1    48 embryonic S3    26 leg disc CME L1    36 wing disc CME-W2    35 wing disc ML-DmD8    105 wing disc ML-DmD9    71 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    50 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    60 mixed discs ML-DmD4-c1    63 CNS ML-DmBG1-c1    72 CNS ML-DmBG2-c2    88 tumorous blood cells mbn2    28 ovary fGS/OSS    24 ovary OSC    21 ovary OSS    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    50 Schneider line 2 Sg4    40 embryonic 1182-4H    38 embryonic GM2    22 embryonic Kc167    26 embryonic S1    48 embryonic S3    26 leg disc CME L1    36 wing disc CME-W2    35 wing disc ML-DmD8    105 wing disc ML-DmD9    71 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    50 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    60 mixed discs ML-DmD4-c1    63 CNS ML-DmBG1-c1    72 CNS ML-DmBG2-c2    88 tumorous blood cells mbn2    28 ovary fGS/OSS    24 ovary OSC    21 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (50) Schneider line 2 Sg4  (40) embryonic 1182-4H  (38) embryonic GM2    22 embryonic Kc167  26 embryonic S1  (48) embryonic S3  26 leg disc CME L1  (36) wing disc CME-W2  (35) wing disc ML-DmD8  (105) wing disc ML-DmD9  (71) wing disc ML-DmD16-c3  (44) wing disc ML-DmD21  (50) wing disc ML-DmD32  (66) haltere disc ML-DmD17-c3  (38) eye-antennal disc ML-DmD11  (51) antennal disc ML-DmD20-c5  (60) mixed discs ML-DmD4-c1  (63) CNS ML-DmBG1-c1  (72) CNS ML-DmBG2-c2  (88) tumorous blood cells mbn2  28 ovary fGS/OSS    24 ovary OSC    21 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    50 Schneider line 2 Sg4    40 embryonic 1182-4H    38 embryonic GM2    22 embryonic Kc167    26 embryonic S1    48 embryonic S3    26 leg disc CME L1    36 wing disc CME-W2    35 wing disc ML-DmD8  105 wing disc ML-DmD9    71 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    50 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    60 mixed discs ML-DmD4-c1    63 CNS ML-DmBG1-c1    72 CNS ML-DmBG2-c2    88 tumorous blood cells mbn2    28 ovary fGS/OSS    24 ovary OSC    21 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    50 Schneider line 2 Sg4    40 embryonic 1182-4H    38 embryonic GM2    22 embryonic Kc167    26 embryonic S1    48 embryonic S3    26 leg disc CME L1    36 wing disc CME-W2    35 wing disc ML-DmD8    105 wing disc ML-DmD9    71 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    50 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    60 mixed discs ML-DmD4-c1    63 CNS ML-DmBG1-c1    72 CNS ML-DmBG2-c2    88 tumorous blood cells mbn2    28 ovary fGS/OSS    24 ovary OSC    21 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  (29) Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  (27) Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  29 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  27 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RE02417 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024491 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6046-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Bin1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | heat sensitive Bin1R7-18 lethal | larval stage | recessive | heat sensitive Bin1R7-18 lethal | maternal effect Bin1R7-18 lethal | pupal stage | recessive | heat sensitive Bin1R7-18 viable Bin1R7-18 viable, with Scer\GAL4pnr-MD237 Bin1GD4266 Other Phenotypes Allele enhancer of variegation, with P{UAS-lacZ.Abd-B.24F6}GCD-6/+: Bin1R7-18 visible (with Df(3R)sbd45) Bin118 Bin1EP3462 Bin1R7-18 visible | homeotic (with Df(3R)sbd26), with Scer\GAL4[-]: Bin1EP3462 Phenotype manifest in Allele abdominal sternite bristle | ectopic (with Df(3R)sbd26), with Scer\GAL4[-]: Bin1EP3462 abdominal sternite bristle | ectopic (with Df(3R)sbd45) Bin1EP3462 Bin118 Bin1R7-18 adult abdominal segment 5 | ectopic (with Df(3R)sbd26), with Scer\GAL4[-]: Bin1EP3462 adult abdominal segment 6 (with Df(3R)sbd26), with Scer\GAL4[-]: Bin1EP3462 adult abdominal segment 6 (with Df(3R)sbd45) Bin1EP3462 Bin118 Bin1R7-18 cephalopharyngeal skeleton | germline clone Bin1R7-18 embryonic/first instar larval cuticle | anterior | germline clone Bin1R7-18
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of Bin1 Class Mutagen Stocks Known lesion Bin1EP3462 P-element activity 1 Yes Bin1f04637 1 -- Bin1f05005 piggyBac transposase 1 -- Bin1G13322 P-element activity 1 -- Bin1G4692 P-element activity 1 -- Bin1R7-18 amorphic allele - molecular evidence, heat sensitive loss of function allele Delta2-3 0 Yes Bin118 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Bin1 Class Mutagen Stocks Known lesion Bin1GD4266 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Bin1GL00127 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Bin1JF01496 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Bin1KK101365 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Bin1+t4 in vitro construct - genomic fragment 0 Yes Bin1Act5C.PZ in vitro construct - regulatory fusion 0 Yes Bin1cHa in vitro construct - genomic fragment 0 Yes Bin1GD17515 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Bin1NIG.6046R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Bin1T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Bin112 (Singh et al., 2005) Df(3R)Bin1170 (Singh et al., 2005) Df(3R)Exel6268 (Ryder, 2004.4.26)
Partially disrupted in	Df(3R)Bin1R7-18 (Singh et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4266} NA P{GD17515} NA P{KK101365} NA P{NIG.6046R} NA P{TRiP.GL00127} NA P{TRiP.JF01496} NA characterization construct P{Bin1-HA} NA P{sracHa} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Bin1G4692 NA P{EP}Bin1G13322 NA P{EP}sraEP3462 NA miscellaneous insertions P{?EP}Bin118 NA P{?EP}Bin1R7-18 NA P{UASp-YFP.Rab11}sra32 NA PBac{WH}Bin1f04637 NA PBac{WH}Bin1f05005 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with bcd (Zhu et al., 2001) transcription corepressor activity inferred from genetic interaction with Kr (Matyash et al., 2009) transcription factor binding inferred from physical interaction with Kr (Matyash et al., 2009)
Biological Process
CV term Evidence References
chromatin silencing inferred from genetic interaction with Kr (Matyash et al., 2009) negative regulation of transcription, DNA-dependent inferred from direct assay (Zhu et al., 2001) inferred from genetic interaction with Kr (Matyash et al., 2009)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
transcription corepressor activity non-traceable author statement (Zhu, 2000.8.19)
Biological Process
CV term Evidence References
mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) negative regulation of transcription from RNA polymerase II promoter non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) Sin3 complex inferred from sequence or structural similarity with EMBL:U96915 (Zhu et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Bin1 - Acn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - Bacc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - CG5792 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - CG9769 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - CaBP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - Inos anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - Pgam5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - Psi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - RPA2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - RnpS1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - RpL7-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - Rrp4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - bcd two hybrid (Zhu and Hanes, 2000) Bin1 - eIF6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - flw anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - mRpL44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - mRpS33 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bin1 - nonA-l anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Bin1 allele Gene References Bin1R7-18 bcd (Singh et al., 2005) unspecified Trl (Espinas et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67016 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0024491 DroID - A comprehensive database of gene and protein interactions. • FBgn0024491 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41965
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG65B222 Dipteran inclusive ortholog search EOG61G3DG Insect inclusive ortholog search EOG62RC4V Arthropod inclusive ortholog search EOG6BZKK4 Metazoa inclusive ortholog search EOG60PH2X
Orthologs in Drosophila Species (EOG65B222)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Bin1     Drosophila simulans   Dsim\GD20305 Y   Drosophila sechellia   Dsec\GM25728 Y   Drosophila erecta   Dere\GG20135 Y   Drosophila yakuba   Dyak\GE26332 Y   Drosophila ananassae   Dana\GF18851 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19319 Y   Drosophila persimilis   Dper\GL12401 Y   Drosophila willistoni   Dwil\GK14011 Y   Drosophila virilis   Dvir\GJ23830 Y   Drosophila mojavensis   Dmoj\GI10094 Y   Drosophila grimshawi   Dgri\GH18835 Y
Orthologs in non-Drosophila Dipterans (EOG61G3DG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014368   Anopheles gambiae Malaria mosquito  Agam\AGAP003036   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016843   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019983
Orthologs in non-Dipteran Insects (EOG62RC4V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52889   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG022803   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13363   Atta cephalotes Leafcutter ant  Acep\ACEP24849   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19288   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20126   Linepithema humile Argentine ant  Lhum\LH11313   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11111   Solenopsis invicta Red fire ant  Sinv\SINV24855   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004205   Bombyx mori Silkmoth  Bmor\BGIBMGA011014   Pediculus humanus Human body louse  Phum\PHUM106410   Tribolium castaneum Red flour beetle  Tcas\TC000183
Orthologs in non-Insect Arthropods (EOG6BZKK4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\PCDH19   Ixodes scapularis Deer tick  Isca\ISCW014075
Orthologs in non-Arthropod Metazoa (EOG60PH2X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C16C10.4   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004858gn   Danio rerio Zebrafish  Drer\sap18   Xenopus tropicalis Western clawed frog  Xtro\sap18   Gallus gallus Domestic chicken  Ggal\chSAP18   Mus musculus House mouse  Mmus\Gm10094   Mus musculus House mouse  Mmus\Gm10094   Rattus norvegicus Norway rat  Rnor\RGD1561590   Rattus norvegicus Norway rat  Rnor\Sap18   Homo sapiens Human  Hsap\ENSG00000150459
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000150459
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20305 Drosophila sechellia Dsec\GM25728 Drosophila erecta Dere\GG20135 Drosophila yakuba Dyak\GE26332 Drosophila ananassae Dana\GF18851 Drosophila pseudoobscura pseudoobscura Dpse\GA19319 Drosophila persimilis Dper\GL12401 Drosophila willistoni Dwil\GK14011 Drosophila virilis Dvir\GJ23830 Drosophila mojavensis Dmoj\GI10094 Drosophila grimshawi Dgri\GH18835
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	33574 w1118; P{EP}Bin1G4692 31801 w1118; P{EP}Bin1G13322 31048 y1 v1; P{TRiP.JF01496}attP2 36781 y1 sc* v1; P{TRiP.GL00127}attP2 17130 w1118; P{EP}sraEP3462 Bin1EP3462
Harvard	- PBac{WH}Bin1f04637 - PBac{WH}Bin1f05005
VDRC	v105352 P{KK101365}VIE-260B v15710 w1118; P{GD4266}v15710
Genomic Clones ( 1 )
	BACR37I18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 72 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE02417
Other clones	DPiM_FI01006 FI01006
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT20679 RE15870 RE21851 RE37860
Other clones	32231 42793 75484 78958 165493 214281.29 Dmel_dig_019434_0622_0305 EC31794 EK141961 EK157736 EK207328 EP02136 FGA001B09 FGM206H07 FGM309F10 FGM315H12 RM01852 RM02052 RM02252 RM02352 RM02452 RM02552 RP001018109 RP001025076 RP001034393 RP001051278 RP003048270 RP003098467 RP003166862 RP003169168 RP003179849 RP003180755 RP003181397 RP003192043 RP003239672 RP003255027 RP003258953 RP003283644 RP003285106 RP003301914 RP003305853 RP003311085 RP003332962 RP003335440 RP003388611 RP003414840 RP003450257 RP003455573 RP003459657 RP003463220 RP003470562 RP003498243 RP003512903 RP003525455 RP003533654 RP003534680 RP003538252 RP003557266 RP003562807 RP003580291 RP003584600 RP003602252 RP003625493 RP003632019 RP003643187
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024491 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41965
Antibody Information
	polyclonal (Pile et al., 2002, Costa et al., 2006)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: SAP18 CG6046 (FlyBase, 1996-)
Source for database merge of	Source for merge of: Bin1 BcDNA:RE02417 (FlyBase, 1996-)
Additional comments	Su(var)3-102 mutants show no change in the Bin1 coding region. (Zhu et al., 2001) Source for merge of Bin1 BcDNA:RE02417 was a shared cDNA (date:030728). (FlyBase, 1996-) Source for identity of SAP18 CG6046 was sequence comparison (date:000721). (FlyBase, 1996-)
Other Comments
	Double heterozygous progeny from crosses using sra and Bin1 mutant alleles are viable and fertile at 22oC and 25oC. (Singh et al., 2005) Identification: Interacts with bcd protein bound to DNA in a modified yeast two-hybrid screen. (Zhu and Hanes, 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079653 RefSeq (Proteins) • NP_524377 DDBJ / EMBL / GenBank • AAF55284 AAG34996 AAL48535 AF297546 AJ278500 AQ254719 AY070913 BI163100 CAB95728 CZ487593 CZ487594 Entrez Gene - A searchable database of RefSeq genes. • 41965 UniProtKB/Swiss-Prot • Q9VEX9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Sin3 associated polypeptide p18 (IPR010516) Histone deacetylase complex, SAP18 subunit (IPR017250) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE02417
Linkouts
	BioGRID - A database of protein and genetic interactions • 67016 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0024491 DroID - A comprehensive database of gene and protein interactions. • FBgn0024491 DRSC - Results from RNAi screens. • FBgn0024491 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024491 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6046-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024491 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41965 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/sap18.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41965 modMine - Data generated by the modENCODE project. • FBgn0024491
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	150001_at (Kristensen et al., 2005) BcDNA:RE02417   bin1 (Zhu and Hanes, 2000, Herold et al., 2009) Bin1 (Zhang et al., 2007, Toku et al., 2011, Japanese National Institute of Genetics, 2012.5.21) Bin 1 (Kasuya et al., 2009) bin1/dSAP18 (Zhu et al., 2001) CG6046 (Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Herold et al., 2009, Ni et al., 2008) dSAP18 (Singh and Hanes, 2004, Singh and Hanes, 2003, Wang et al., 2002, Zhao et al., 2002, Singh et al., 2002, Singh et al., 2001, Espinas et al., 2000, Jones, 2000.3.9, Zhu and Hanes, 2000, Wang et al., 2000, Taylor-Harding et al., 2004, Matyash et al., 2009) dSap18 (Beilfuss et al., 2003) dsap18 (Canudas et al., 2005, Costa et al., 2006) SAP18 (Ma, 2005, Lehmann, 2004, Jones and Kadonaga, 2000, Espinas, 2000.6.22, Ishii, 2005, Pile et al., 2002, Murachelli et al., 2012) sap18 (Singh et al., 2005, Horner, 2006)
Name Synonym	Bicoid interacting protein 1 (Zhu and Hanes, 1998, Kasuya et al., 2009) Sin3A-associated polypeptide p18 (Singh et al., 2001) SIN3-associated polypeptide 18 (Pile et al., 2002)
Secondary FlyBase IDs
	FBgn0038406 FBgn0047185
References ( 58 )
Generate a list of	All references relating to this gene ( 58 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 7 ) Review  ( 3 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 8 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Murachelli et al., 2012, Nat. Struct. Mol. Biol. 19(4): 378--386 The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex. [FBrf0218368] Costa et al., 2011, FEBS Lett. 585(2): 275--280 Drosophila melanogaster SAP18 protein is required for environmental stress responses. [FBrf0212789] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...