FB2021_06, released December 14, 2021

Gene: Dmel\dlt

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General Information
Symbol
Dmel\dlt
Species
D. melanogaster
Name
discs lost
Annotation Symbol
CG32315
Feature Type
protein_coding_gene
FlyBase ID
FBgn0024510
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
discs lost (dlt) encodes a protein required for cell survival and cell cycle progression in imaginal discs. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Vanaso, l(3)04276, l(3)dre1, Van, l(3)62Ba

Key Links
Genomic Location
Cytogenetic map
62B4-62B4
Sequence location
Recombination map
3-1.0
RefSeq locus
NT_037436 REGION:1789631..1795328
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in imaginal disc morphogenesis
inferred from mutant phenotype
(assigned by UniProt )
(Pielage et al., 2003)
involved_in olfactory behavior
inferred from expression pattern
(Fanara et al., 2002)
involved_in regulation of cell population proliferation
inferred from mutant phenotype
(assigned by UniProt )
(Pielage et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in chromatin organization
inferred from biological aspect of ancestor with PANTHER:PTN002010693
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in morphogenesis of a polarized epithelium
traceable author statement
(Gibson and Perrimon, 2003)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(assigned by UniProt )
(Pielage et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002010693
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
discs lost (dlt) encodes a protein required for cell survival and cell cycle progression in imaginal discs. [Date last reviewed: 2018-09-20]
Protein Function (UniProtKB)
Regulator of cell proliferation and cell survival of differentiated cells independent of cell division. Essential for imaginal disks formation. Not involved in cell polarity.
(UniProt, Q8T626)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\dlt for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.46

Shares 5' UTR with downstream gene.

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
dlt-RA
FBtr0072790
NM_167916
4000
1240
Additional Transcript Data and Comments
Reported size (kB)

3.5 (northern blot)

(Bhat et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
dlt-PA
FBpp0072673
139.5
1240
6.92
NP_728672
AAF47570
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

800 (aa); 98 (kD observed); 88 (kD predicted)

(Bhat et al., 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dlt using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
epithelial cell
(Bhat et al., 1999)
embryonic stage -- adult stage
(Bhat et al., 1999)
Additional Descriptive Data

dlt transcripts are detected at all developmental stages on northern blots. Expression is observed in many epithelial cells of ectodermal origin by in situ hybridization.

(Bhat et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval salivary gland
(Bhat et al., 1999)
ectoderm
(Bhat et al., 1999)
embryonic/larval trachea
(Bhat et al., 1999)
embryonic/larval hindgut
(Bhat et al., 1999)
embryonic/larval foregut
(Bhat et al., 1999)
embryonic cycle 14
furrow canal
(Lecuit et al., 2002)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data

Protein is detected in the furrow canal region on the membrane of cellularizing embryos.

(Lecuit et al., 2002)

dlt protein is first detected at mitotic cycle 11 and is membrane-associated. It is present at the leading edge of the invaginating membranes during cellularization. After cellularization, it is exclusively localized to the basal area of the columnar epithelial cells. At all subsequent embryonic stages, it is membrane associated and is found in primary and some secondary epithelial cells including ectodermal cells, salivary glands, foregut, hindgut, and invaginating tracheal cells. It is also detected in some cells of the PNS.

(Bhat et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(assigned by UniProt )
(Pielage et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\dlt in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dlt
Transgenic constructs containing regulatory region of dlt
Aberrations (Deficiencies and Duplications) ( 155 )
Inferred from experimentation ( 155 )
Gene disrupted in
Df(3L)Aprt-1
(Wang et al., 1994)
Df(3L)Aprt-12
(Wang et al., 1994)
Df(3L)Aprt-13
(Wang et al., 1994)
Df(3L)Aprt-16
(Wang et al., 1994)
Df(3L)Aprt-26
(Wang et al., 1994)
Df(3L)Aprt-32
(Wang et al., 1994)
Df(3L)Aprt-46
(Wang et al., 1994)
Df(3L)Aprt-47
(Wang et al., 1994)
Df(3L)Aprt-54
(Wang et al., 1994)
Df(3L)Aprt-56
(Wang et al., 1994)
Df(3L)Aprt-61
(Wang et al., 1994)
Df(3L)Aprt-66
(Wang et al., 1994)
Df(3L)Aprt-72
(Wang et al., 1994)
Df(3L)Aprt-87
(Wang et al., 1994)
Df(3L)Aprt-88
(Wang et al., 1994)
Df(3L)Aprt-92
(Wang et al., 1994)
Df(3L)Aprt-100
(Wang et al., 1994)
Df(3L)Aprt-105
(Wang et al., 1994)
Df(3L)Aprt-106
(Wang et al., 1994)
Df(3L)Aprt-108
(Wang et al., 1994)
Df(3L)Aprt-110
(Wang et al., 1994)
Df(3L)Aprt-112
(Wang et al., 1994)
Df(3L)Aprt-122
(Wang et al., 1994)
Df(3L)Aprt-126
(Machado and Andrew, 2000, Bhat et al., 1999, Wang et al., 1994)
Df(3L)Aprt-133
(Wang et al., 1994)
Df(3L)Aprt-134
(Wang et al., 1994)
Df(3L)Aprt-137
(Wang et al., 1994)
Df(3L)Aprt-143
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-148
(Wang et al., 1994)
Df(3L)Aprt-151
(Wang et al., 1994)
Df(3L)Aprt-152
(Wang et al., 1994)
Df(3L)Aprt-156
(Wang et al., 1994)
Df(3L)Aprt-159
(Wang et al., 1994)
Df(3L)Aprt-162
(Wang et al., 1994)
Df(3L)Aprt-163
(Wang et al., 1994)
Df(3L)Aprt-165
(Wang et al., 1994)
Df(3L)Aprt-166
(Wang et al., 1994)
Df(3L)Aprt-167
(Wang et al., 1994)
Df(3L)Aprt-169
(Wang et al., 1994)
Df(3L)Aprt-177
(Wang et al., 1994)
Df(3L)Aprt-179
(Wang et al., 1994)
Df(3L)Aprt-181
(Wang et al., 1994)
Df(3L)Aprt-184
(Wang et al., 1994)
Df(3L)Aprt-192
(Wang et al., 1994)
Df(3L)Aprt-193
(Wang et al., 1994)
Df(3L)Aprt-194
(Wang et al., 1994)
Df(3L)Aprt-199
(Wang et al., 1994)
Df(3L)Aprt-201
(Wang et al., 1994)
Df(3L)BSC122
(Andrade and Cook, 2005.8.25)
Df(3L)BSC127
(Andrade et al., 2005.10.27)
Df(3L)MY10
(Pielage et al., 2003, Tanentzapf et al., 2000, Bhat et al., 1999)
Df(3L)R-G2
(Lee et al., 1993)
Df(3L)R-G5
(Spradling et al., 1999, Lee et al., 1993)
Df(3L)R-R2
(Lee et al., 1993)
Ts(2Rt;3Rt)Aprt-185
(Wang et al., 1994)
Gene not disrupted in
Df(3L)Aprt-3
(Wang et al., 1994)
Df(3L)Aprt-9
(Wang et al., 1994)
Df(3L)Aprt-10
(Wang et al., 1994)
Df(3L)Aprt-14
(Wang et al., 1994)
Df(3L)Aprt-15
(Wang et al., 1994)
Df(3L)Aprt-18
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-19
(Wang et al., 1994)
Df(3L)Aprt-21
(Wang et al., 1994)
Df(3L)Aprt-24
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-27
(Wang et al., 1994)
Df(3L)Aprt-29
(Wang et al., 1994)
Df(3L)Aprt-31
(Wang et al., 1994)
Df(3L)Aprt-36
(Wang et al., 1994)
Df(3L)Aprt-42
(Wang et al., 1994)
Df(3L)Aprt-48
(Wang et al., 1994)
Df(3L)Aprt-53
(Wang et al., 1994)
Df(3L)Aprt-57
(Wang et al., 1994)
Df(3L)Aprt-65
(Wang et al., 1994)
Df(3L)Aprt-71
(Wang et al., 1994)
Df(3L)Aprt-73
(Wang et al., 1994)
Df(3L)Aprt-74
(Wang et al., 1994)
Df(3L)Aprt-77
(Wang et al., 1994)
Df(3L)Aprt-79
(Wang et al., 1994)
Df(3L)Aprt-84
(Wang et al., 1994)
Df(3L)Aprt-89
(Wang et al., 1994)
Df(3L)Aprt-90
(Wang et al., 1994)
Df(3L)Aprt-91
(Wang et al., 1994)
Df(3L)Aprt-93
(Wang et al., 1994)
Df(3L)Aprt-94
(Wang et al., 1994)
Df(3L)Aprt-95
(Wang et al., 1994)
Df(3L)Aprt-96
(Wang et al., 1994)
Df(3L)Aprt-97
(Wang et al., 1994)
Df(3L)Aprt-98
(Wang et al., 1994)
Df(3L)Aprt-99
(Wang et al., 1994)
Df(3L)Aprt-101
(Wang et al., 1994)
Df(3L)Aprt-102
(Wang et al., 1994)
Df(3L)Aprt-103
(Wang et al., 1994)
Df(3L)Aprt-104
(Wang et al., 1994)
Df(3L)Aprt-107
(Wang et al., 1994)
Df(3L)Aprt-109
(Wang et al., 1994)
Df(3L)Aprt-111
(Wang et al., 1994)
Df(3L)Aprt-113
(Wang et al., 1994)
Df(3L)Aprt-114
(Wang et al., 1994)
Df(3L)Aprt-115
(Wang et al., 1994)
Df(3L)Aprt-116
(Wang et al., 1994)
Df(3L)Aprt-117
(Wang et al., 1994)
Df(3L)Aprt-118
(Wang et al., 1994)
Df(3L)Aprt-119
(Wang et al., 1994)
Df(3L)Aprt-120
(Wang et al., 1994)
Df(3L)Aprt-121
(Wang et al., 1994)
Df(3L)Aprt-123
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-124
(Wang et al., 1994)
Df(3L)Aprt-125
(Wang et al., 1994)
Df(3L)Aprt-127
(Wang et al., 1994)
Df(3L)Aprt-128
(Wang et al., 1994)
Df(3L)Aprt-129
(Wang et al., 1994)
Df(3L)Aprt-130
(Wang et al., 1994)
Df(3L)Aprt-131
(Wang et al., 1994)
Df(3L)Aprt-132
(Wang et al., 1994)
Df(3L)Aprt-135
(Wang et al., 1994)
Df(3L)Aprt-136
(Wang et al., 1994)
Df(3L)Aprt-138
(Wang et al., 1994)
Df(3L)Aprt-139
(Wang et al., 1994)
Df(3L)Aprt-140
(Wang et al., 1994)
Df(3L)Aprt-141
(Wang et al., 1994)
Df(3L)Aprt-142
(Wang et al., 1994)
Df(3L)Aprt-144
(Wang et al., 1994)
Df(3L)Aprt-145
(Wang et al., 1994)
Df(3L)Aprt-146
(Wang et al., 1994)
Df(3L)Aprt-147
(Wang et al., 1994)
Df(3L)Aprt-149
(Wang et al., 1994)
Df(3L)Aprt-150
(Wang et al., 1994)
Df(3L)Aprt-153
(Wang et al., 1994)
Df(3L)Aprt-154
(Wang et al., 1994)
Df(3L)Aprt-157
(Wang et al., 1994)
Df(3L)Aprt-158
(Wang et al., 1994)
Df(3L)Aprt-160
(Wang et al., 1994)
Df(3L)Aprt-161
(Wang et al., 1994)
Df(3L)Aprt-164
(Wang et al., 1994)
Df(3L)Aprt-168
(Wang et al., 1994)
Df(3L)Aprt-170
(Wang et al., 1994)
Df(3L)Aprt-171
(Wang et al., 1994)
Df(3L)Aprt-172
(Wang et al., 1994)
Df(3L)Aprt-173
(Wang et al., 1994)
Df(3L)Aprt-174
(Wang et al., 1994)
Df(3L)Aprt-178
(Wang et al., 1994)
Df(3L)Aprt-179
(Wang et al., 1994)
Df(3L)Aprt-180
(Wang et al., 1994)
Df(3L)Aprt-182
(Wang et al., 1994)
Df(3L)Aprt-183
(Wang et al., 1994)
Df(3L)Aprt-186
(Wang et al., 1994)
Df(3L)Aprt-187
(Wang et al., 1994)
Df(3L)Aprt-188
(Wang et al., 1994)
Df(3L)Aprt-189
(Wang et al., 1994)
Df(3L)Aprt-190
(Wang et al., 1994)
Df(3L)Aprt-191
(Wang et al., 1994)
Df(3L)Aprt-195
(Wang et al., 1994)
Df(3L)Aprt-196
(Wang et al., 1994)
Df(3L)Aprt-198
(Wang et al., 1994)
Df(3L)Ar14-8
(Spradling et al., 1999)
Df(3L)R-E
(Lee et al., 1993)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | first instar larval stage
lethal | late embryonic stage
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage (with Df(3L)Aprt-32)
lethal - all die before end of pupal stage | recessive
partially lethal - majority live, with Scer\GAL4btl.PS
partially lethal - majority live, with Scer\GAL4dpp.blk1
partially lethal - majority live, with Scer\GAL4Kr.PM
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell size, with Scer\GAL4ptc-559.1
abnormal size | adult stage
abnormal size | adult stage | somatic clone
decreased cell number, with Scer\GAL4ptc-559.1
increased cell death, with Scer\GAL4ptc-559.1
increased cell death | somatic clone
some die during larval stage
some die during larval stage | recessive
some die during pupal stage
some die during pupal stage (with Df(3L)Aprt-32)
some die during pupal stage | recessive
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
antenna
chaeta, with Scer\GAL4pnr-MD237
crossvein, with Scer\GAL4ptc-559.1
embryonic/larval salivary gland | embryonic stage
eye
eye, with Scer\GAL4ey.PH
eye | somatic clone
eye-antennal disc
follicle cell | somatic clone
imaginal disc
leg
trichogen cell, with Scer\GAL4pnr-MD237
wing, with Scer\GAL4ptc-559.1
wing disc | somatic clone
wing hair | increased number, with Scer\GAL4ptc-559.1
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CDAN1
12 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cdan1
11 of 15
Yes
Yes
Mmus\Ttbk2
1 of 15
No
No
Rattus norvegicus (Norway rat) (1)
Rnor\Cdan1
7 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\cdan1
7 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\cdan1
8 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919045K )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD13437
Drosophila sechellia
Dsec\GM14168
Drosophila erecta
Dere\GG14559
Drosophila yakuba
Dyak\GE20914
Drosophila ananassae
Dana\GF24961
Drosophila pseudoobscura pseudoobscura
Dpse\GA16826
Drosophila persimilis
Dper\GL16207
Drosophila willistoni
Dwil\GK20503
Drosophila virilis
Dvir\GJ16070
Drosophila mojavensis
Dmoj\GI12772
Drosophila grimshawi
Dgri\GH15716
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502VU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022774
Mayetiola destructor
Hessian fly
Mdes\Mdes010622
Mayetiola destructor
Hessian fly
Mdes\Mdes015210
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004917
Anopheles darlingi
American malaria mosquito
Adar\ADAC005203
Anopheles gambiae
Malaria mosquito
Agam\AGAP010055
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016914
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02N9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA011154
Danaus plexippus
Monarch butterfly
Dple\DPOGS203097-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011569
Apis florea
Little honeybee
Aflo\2717986244
Apis mellifera
Western honey bee
Amel\GB54332
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17893
Bombus terrestris
Buff-tailed bumblebee
Bter\15206320
Linepithema humile
Argentine ant
Lhum\LH12183
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00061d
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002db9
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG030708
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02115
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15308
Pediculus humanus
Human body louse
Phum\PHUM405140
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005396
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12672
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02KG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009062
Ixodes scapularis
Black-legged tick
Isca\ISCW017093
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79692.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79691.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur13g00120
Tetranychus urticae
Two-spotted spider mite
Turt\tetur13g00080
Tetranychus urticae
Two-spotted spider mite
Turt\tetur15g00410
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_326470
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03X8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CDNA1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cdan1L
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002411
Gallus gallus
Domestic chicken
Ggal\CDAN1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    CDAN1; codanin 1
    model of  congenital dyserythropoietic anemia type Ia
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CDAN1; codanin 1
    12 of 15
    607465
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    dlt
    enhanceable
    CycE
    (Pielage et al., 2003)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-1.0
    Cytogenetic map
    62B4-62B4
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    62B4-62B4
    Limits computationally determined from genome sequence between P{EP}rhoEP3704&P{PZ}l(3)0622606226 and P{PZ}dlt04276
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    62B1-62B8
    (Anholt et al., 2002)
    62B4-62B5
    (determined by in situ hybridisation)
    (Spradling et al., 1999)
    62B4-62B5
    (BDGP Project Members, 1994-1999)
    Localised by deficiency mapping (details unspecified).
    (Anholt et al., 2002)
    Experimentally Determined Recombination Data
    Location

    3-1.0

    (FlyBase, 2016)

    3-2.7

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (8)
    Genomic Clones (13)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (29)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Bhat et al., 1999)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Van l(3)04276

      (Anholt et al., 2002)

      Source for identity of: Vanaso CG32315

      (FlyBase Genome Annotators, 2002-2003)
      Source for database merge of

      Source for merge of: dlt l(3)62Ba

      (Bhat et al., 1999)
      Additional comments

      The "dre1/dlt" complementation group corresponds to the CG32315 gene and not to CG12021. It was previously reported in FBrf0107610 that the relevant locus for the "dre1" (dlt) complementation group was CG12021, based on mapping and complementation data (shown in Figure 4. of FBrf0107610). However, it has recently been shown (FBrf0167484) that "dre1" is allelic to CG32315 rather than CG12021. Re-evaluation of the "dre1" mutation indicates that the chromosome carries a T516S amino acid change in CG12021 and a stop codon at position 865 in CG32315. Since the mutation in CG12021 is conservative, it may not underlie the loss of imaginal discs observed in "dre1" mutants, and instead, the "dre1" mutant phenotypes described in FBrf0107610 are likely due to the mutation in CG32315. This is also supported by the observation that the P{PatjEHHS} construct (Figure 4 of FBrf0107610) now fails to rescue the "dre1" mutation. In addition, the "dre1" mutation fails to complement an allele in CG32315 ("Van04276"), clearly implicating CG32315 as causing the lethality associated with "dre1". It remains possible that the "dre1" phenotypes shown in Figure 6 of FBrf0107610 may result from a combination of mutations in both genes. Overexpression of CG12021 causes a severe loss of epithelial polarity as shown in Figure 7. of FBrf0107610. FlyBase curator comment: the T516S amino acid change in CG12021 on the "dre1" chromosome is represented by the allele Patjdre1 and the stop codon at position 865 in CG32315 on the "dre1" chromosome is represented by the allele dltdre1.

      (Bhat et al., 2003)

      The dlt phenotype maps to the CG32315 annotation, not the CG12021 annotation, as was reported previously (FBrf0107610).

      (Klämbt, 2003.10.31)

      The P-element induced alleles dltP1, dltP2 and dltP4 do not complement mutations in α-Spec.

      (Pielage et al., 2003)

      One or more of the processed transcripts for this gene share(s) untranslated sequences with a transcript of an adjacent gene, but encode(s) a single open reading frame (ORF). The non-overlapping ORFs that share untranslated sequences are represented by dlt and α-Spec.

      (FlyBase Genome Annotators, 2002-2003)
      Other Comments

      The dlt open reading frame is located within the first intron of α-Spec and the two genes share a common first untranslated exon. Overall orientation not stated: Patj- CG12020- Cdc37- α-Spec+ dlt+ α-Spec+

      (Pielage et al., 2003)

      Identification: as a female-specific quantitative trait locus affecting variation in olfactory avoidance response to benzaldehyde.

      (Anholt et al., 2002)

      dlt is expressed exclusively in the third antennal segment.

      (Anholt et al., 2002)

      Mutations cause pupal lethality with third instar larvae devoid of imaginal discs.

      (Bhat et al., 1998)

      Recessive lethal mutations in this complementation group were identified by failure to complement the recessive lethality of Df(3L)R-R2.

      (Sliter et al., 1989)

      FlyBase curator comment: The gene corresponding to genome annotation CG12021 was named " dlt:discs lost" in FBrf0107610. Subsequently the "dlt" phenotype was shown to map not to CG12021, but to the gene corresponding to genome annotation CG32315. Consequently the " dlt:discs lost" name was moved to CG32315, and the name of the gene for CG12021 was changed to "Patj". See Klaembt, 2003.10.31, personal communication to FlyBase

      Origin and Etymology
      Discoverer
      Etymology

      The gene is named "Vanaso" since segregation of putative alleles in Oregon and 2b strains causes additive genetic variance (V[[A]]) in olfactory avoidance behaviour ("naso" is a Spanish term for nose).

      (Fanara et al., 2002)
      Identification
      External Crossreferences and Linkouts ( 40 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      Synonyms and Secondary IDs (16)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (75)