• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\dlt

General Information
Symbol	Dmel\dlt	Species	D. melanogaster
Name	discs lost	Annotation symbol	CG32315
Feature type	protein_coding_gene	FlyBase ID	FBgn0024510
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	l(3)04276, l(3)dre1, Van, dre1
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	62B4-62B4	Sequence location	3L:1,789,625..1,795,318 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene discs lost is referred to in FlyBase by the symbol Dmel\dlt (CG32315, FBgn0024510). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: S phase of mitotic cell cycle; olfactory behavior; lateral inhibition; cellular process; imaginal disc morphogenesis; regulation of cell proliferation. 23 alleles are reported. The phenotypes of these alleles are annotated with: eye-antennal disc; leg; eye; trichogen cell; crossvein; chaeta; wing; imaginal disc. It has one annotated transcript and one annotated polypeptide. Protein features are: Regulator of chromosome condensation, RCC1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1633169_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dlt. Gene sequence location is 3L:1789625..1795318.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA08705 BKN20785
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 62B4-62B4   Limits computationally determined from genome sequence between P{EP}rhoEP3704&P{PZ}l(3)0622606226 and P{PZ}dlt04276
Experimentally Determined Cytological Location
Cytogenetic map Notes References 62B4-62B5   (determined by in situ hybridisation)   (Spradling et al., 1999) 62B4-62B5     (BDGP Project Members, 1994-1999) 62B1-62B8   Localised by deficiency mapping (details unspecified).   (Anholt et al., 2002)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dlt for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dlt-RA FBtr0072790  NM_167916   3996   1240
Additional Transcript Data & Comments
Reported size (kB)	3.5 (northern blot) (Bhat et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dlt-PA   FBpp0072673   139.5   1240   6.92     NP_728672   AAF47570
Additional Polypeptide Data & Comments
Reported size (kDa)	800 (aa); 98 (kD observed); 88 (kD predicted) (Bhat et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Regulator of chromosome condensation, RCC1 (IPR000408)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201401   AA201566   AA392378   AA440994   AA441009   AA536595   AA538806   AA540553   AA540560   AA541027   AA949786   AA950541   AE014296 AAF47570   AF487673   AF487674 AAM18043   AF487675   AF487676   AF487677 AAM18044   AF487678   AQ026196   AW942985   AY051770 AAK93194   BF496147   BF505490   BG634548   BG638100   BI172455   BI372251   BI578280   BI629716   CK659542   CO267726   CO280759   CO339267   CO341173   EC075441   EC222096   EC237435   EC252972   EC257853   EV592402
UniProtKB/Swiss-Prot	Q8T626
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   epithelial cell   (Bhat et al., 1999) embryonic stage -- adult stage     (Bhat et al., 1999)
Additional Descriptive Data
	dlt transcripts are detected at all developmental stages on northern blots. Expression is observed in many epithelial cells of ectodermal origin by in situ hybridization. (Bhat et al., 1999)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval salivary gland   (Bhat et al., 1999) ectoderm   (Bhat et al., 1999) embryonic/larval trachea   (Bhat et al., 1999) embryonic/larval hindgut   (Bhat et al., 1999) embryonic/larval foregut   (Bhat et al., 1999) embryonic cycle 14   furrow canal   • plasma membrane (Lecuit et al., 2002) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
	dlt protein is first detected at mitotic cycle 11 and is membrane-associated. It is present at the leading edge of the invaginating membranes during cellularization. After cellularization, it is exclusively localized to the basal area of the columnar epithelial cells. At all subsequent embryonic stages, it is membrane associated and is found in primary and some secondary epithelial cells including ectodermal cells, salivary glands, foregut, hindgut, and invaginating tracheal cells. It is also detected in some cells of the PNS. (Bhat et al., 1999) Protein is detected in the furrow canal region on the membrane of cellularizing embryos. (Lecuit et al., 2002)
Marker for
Subcellular Localization
CV Term	plasma membrane (Bhat et al., 1999)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0024510    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0024510 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0024510 expression level Developmental Stage   Expression Level embryo 00-02hr    1626 embryo 02-04hr    1955 embryo 04-06hr    1604 embryo 06-08hr    1416 embryo 08-10hr    1168 embryo 10-12hr    813 embryo 12-14hr    717 embryo 14-16hr    834 embryo 16-18hr    655 embryo 18-20hr    437 embryo 20-22hr    755 embryo 22-24hr    742 larva L1    220 larva L2    245 larva L3 12hr old    194 larva L3 puffstage 1-2    159 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    257 white prepupae new    264 white prepupae 12hr    257 white prepupae 24hr    367 pupae 2d postWPP    318 pupae 3d postWPP    216 pupae 4d postWPP    147 adult male 01day    217 adult male 05day    260 adult male 30day    230 adult female 01day    494 adult female 05day    1045 adult female 30day    943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1626) embryo 02-04hr  (1955) embryo 04-06hr  (1604) embryo 06-08hr  (1416) embryo 08-10hr  (1168) embryo 10-12hr  (813) embryo 12-14hr  (717) embryo 14-16hr  (834) embryo 16-18hr  (655) embryo 18-20hr  (437) embryo 20-22hr  (755) embryo 22-24hr  (742) larva L1  (220) larva L2  (245) larva L3 12hr old  (194) larva L3 puffstage 1-2  (159) larva L3 puffstage 3-6  (204) larva L3 puffstage 7-9  (257) white prepupae new  (264) white prepupae 12hr  (257) white prepupae 24hr  (367) pupae 2d postWPP  (318) pupae 3d postWPP  (216) pupae 4d postWPP  (147) adult male 01day  (217) adult male 05day  (260) adult male 30day  (230) adult female 01day  (494) adult female 05day  (1045) adult female 30day  (943) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1626) embryo 02-04hr  (1955) embryo 04-06hr  (1604) embryo 06-08hr  1416 embryo 08-10hr    1168 embryo 10-12hr    813 embryo 12-14hr    717 embryo 14-16hr    834 embryo 16-18hr    655 embryo 18-20hr    437 embryo 20-22hr    755 embryo 22-24hr    742 larva L1    220 larva L2    245 larva L3 12hr old    194 larva L3 puffstage 1-2    159 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    257 white prepupae new    264 white prepupae 12hr    257 white prepupae 24hr    367 pupae 2d postWPP    318 pupae 3d postWPP    216 pupae 4d postWPP    147 adult male 01day    217 adult male 05day    260 adult male 30day    230 adult female 01day    494 adult female 05day    1045 adult female 30day    943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1626 embryo 02-04hr    1955 embryo 04-06hr    1604 embryo 06-08hr    1416 embryo 08-10hr    1168 embryo 10-12hr    813 embryo 12-14hr    717 embryo 14-16hr    834 embryo 16-18hr    655 embryo 18-20hr    437 embryo 20-22hr    755 embryo 22-24hr    742 larva L1    220 larva L2    245 larva L3 12hr old    194 larva L3 puffstage 1-2    159 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    257 white prepupae new    264 white prepupae 12hr    257 white prepupae 24hr    367 pupae 2d postWPP    318 pupae 3d postWPP    216 pupae 4d postWPP    147 adult male 01day    217 adult male 05day    260 adult male 30day    230 adult female 01day    494 adult female 05day    1045 adult female 30day    943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1626 embryo 02-04hr    1955 embryo 04-06hr    1604 embryo 06-08hr    1416 embryo 08-10hr    1168 embryo 10-12hr    813 embryo 12-14hr    717 embryo 14-16hr    834 embryo 16-18hr    655 embryo 18-20hr    437 embryo 20-22hr    755 embryo 22-24hr    742 larva L1    220 larva L2    245 larva L3 12hr old    194 larva L3 puffstage 1-2    159 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    257 white prepupae new    264 white prepupae 12hr    257 white prepupae 24hr    367 pupae 2d postWPP    318 pupae 3d postWPP    216 pupae 4d postWPP    147 adult male 01day    217 adult male 05day    260 adult male 30day    230 adult female 01day    494 adult female 05day    1045 adult female 30day    943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0024510 expression level Developmental Stage   Expression Level embryo 00-02hr    1626 embryo 02-04hr    1955 embryo 04-06hr    1604 embryo 06-08hr    1416 embryo 08-10hr    1168 embryo 10-12hr    813 embryo 12-14hr    717 embryo 14-16hr    834 embryo 16-18hr    655 embryo 18-20hr    437 embryo 20-22hr    755 embryo 22-24hr    742 larva L1    220 larva L2    245 larva L3 12hr old    194 larva L3 puffstage 1-2    159 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    257 white prepupae new    264 white prepupae 12hr    257 white prepupae 24hr    367 pupae 2d postWPP    318 pupae 3d postWPP    216 pupae 4d postWPP    147 adult male 01day    217 adult male 05day    260 adult male 30day    230 adult female 01day    494 adult female 05day    1045 adult female 30day    943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1626) embryo 02-04hr  (1955) embryo 04-06hr  (1604) embryo 06-08hr  (1416) embryo 08-10hr  (1168) embryo 10-12hr  (813) embryo 12-14hr  (717) embryo 14-16hr  (834) embryo 16-18hr  (655) embryo 18-20hr  (437) embryo 20-22hr  (755) embryo 22-24hr  (742) larva L1  (220) larva L2  (245) larva L3 12hr old  (194) larva L3 puffstage 1-2  (159) larva L3 puffstage 3-6  (204) larva L3 puffstage 7-9  (257) white prepupae new  (264) white prepupae 12hr  (257) white prepupae 24hr  (367) pupae 2d postWPP  (318) pupae 3d postWPP  (216) pupae 4d postWPP  (147) adult male 01day  (217) adult male 05day  (260) adult male 30day  (230) adult female 01day  (494) adult female 05day  (1045) adult female 30day  (943) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1626 embryo 02-04hr  1955 embryo 04-06hr  1604 embryo 06-08hr  1416 embryo 08-10hr    1168 embryo 10-12hr    813 embryo 12-14hr    717 embryo 14-16hr    834 embryo 16-18hr    655 embryo 18-20hr    437 embryo 20-22hr    755 embryo 22-24hr    742 larva L1    220 larva L2    245 larva L3 12hr old    194 larva L3 puffstage 1-2    159 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    257 white prepupae new    264 white prepupae 12hr    257 white prepupae 24hr    367 pupae 2d postWPP    318 pupae 3d postWPP    216 pupae 4d postWPP    147 adult male 01day    217 adult male 05day    260 adult male 30day    230 adult female 01day    494 adult female 05day    1045 adult female 30day    943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1626 embryo 02-04hr    1955 embryo 04-06hr    1604 embryo 06-08hr    1416 embryo 08-10hr    1168 embryo 10-12hr    813 embryo 12-14hr    717 embryo 14-16hr    834 embryo 16-18hr    655 embryo 18-20hr    437 embryo 20-22hr    755 embryo 22-24hr    742 larva L1    220 larva L2    245 larva L3 12hr old    194 larva L3 puffstage 1-2    159 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    257 white prepupae new    264 white prepupae 12hr    257 white prepupae 24hr    367 pupae 2d postWPP    318 pupae 3d postWPP    216 pupae 4d postWPP    147 adult male 01day    217 adult male 05day    260 adult male 30day    230 adult female 01day    494 adult female 05day    1045 adult female 30day    943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1626 embryo 02-04hr    1955 embryo 04-06hr    1604 embryo 06-08hr    1416 embryo 08-10hr    1168 embryo 10-12hr    813 embryo 12-14hr    717 embryo 14-16hr    834 embryo 16-18hr    655 embryo 18-20hr    437 embryo 20-22hr    755 embryo 22-24hr    742 larva L1    220 larva L2    245 larva L3 12hr old    194 larva L3 puffstage 1-2    159 larva L3 puffstage 3-6    204 larva L3 puffstage 7-9    257 white prepupae new    264 white prepupae 12hr    257 white prepupae 24hr    367 pupae 2d postWPP    318 pupae 3d postWPP    216 pupae 4d postWPP    147 adult male 01day    217 adult male 05day    260 adult male 30day    230 adult female 01day    494 adult female 05day    1045 adult female 30day    943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0024510    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0024510 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0024510 expression level Tissue   Expression Level Larval Central Nervous System    59.575 Larval Midgut    26.6 Larval Hindgut    24.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.6 Larval Trachea    21.325 Larval Carcass    17.175 Adult Head    20.9 Adult Eye    15.4 Adult Brain    39.8 Adult Thoracic-Abdominal Ganglion    34.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    17.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    123.1 Adult Testis    45.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    59.575 Larval Midgut    26.6 Larval Hindgut    24.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.6 Larval Trachea    21.325 Larval Carcass    17.175 Adult Head    20.9 Adult Eye    15.4 Adult Brain    39.8 Adult Thoracic-Abdominal Ganglion    34.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    17.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    123.1 Adult Testis    45.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    59.575 Larval Midgut    26.6 Larval Hindgut    24.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.6 Larval Trachea    21.325 Larval Carcass    17.175 Adult Head    20.9 Adult Eye    15.4 Adult Brain    39.8 Adult Thoracic-Abdominal Ganglion    34.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    17.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    123.1 Adult Testis    45.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    59.575 Larval Midgut    26.6 Larval Hindgut    24.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.6 Larval Trachea    21.325 Larval Carcass    17.175 Adult Head    20.9 Adult Eye    15.4 Adult Brain    39.8 Adult Thoracic-Abdominal Ganglion    34.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    17.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    123.1 Adult Testis    45.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0024510 expression level Tissue   Expression Level Larval Central Nervous System    59.575 Larval Midgut    26.6 Larval Hindgut    24.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.6 Larval Trachea    21.325 Larval Carcass    17.175 Adult Head    20.9 Adult Eye    15.4 Adult Brain    39.8 Adult Thoracic-Abdominal Ganglion    34.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    17.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    123.1 Adult Testis    45.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    59.575 Larval Midgut    26.6 Larval Hindgut    24.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.6 Larval Trachea    21.325 Larval Carcass    17.175 Adult Head    20.9 Adult Eye    15.4 Adult Brain    39.8 Adult Thoracic-Abdominal Ganglion    34.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    17.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    123.1 Adult Testis    45.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    59.575 Larval Midgut    26.6 Larval Hindgut    24.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.6 Larval Trachea    21.325 Larval Carcass    17.175 Adult Head    20.9 Adult Eye    15.4 Adult Brain    39.8 Adult Thoracic-Abdominal Ganglion    34.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    17.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    123.1 Adult Testis    45.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    59.575 Larval Midgut    26.6 Larval Hindgut    24.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.6 Larval Trachea    21.325 Larval Carcass    17.175 Adult Head    20.9 Adult Eye    15.4 Adult Brain    39.8 Adult Thoracic-Abdominal Ganglion    34.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    17.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    123.1 Adult Testis    45.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    20.9   NA  Eye    15.4   NA  Brain    39.8   59.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    34.8   NA  Crop    no informative data   26.6  Midgut    no informative data   24.2  Hindgut    17.8   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   28.6  Salivary Gland    no informative data   NA  Heart    no informative data   21.325  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    123.1   NA  Testis    45.8   NA  Male Accessory Gland    no informative data   17.175  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024510 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32315-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal dlt1 dlt3 lethal | first instar larval stage dltP1 dltP2 dltP4 lethal | larval stage dltdre1 dltN1 lethal | larval stage | recessive dltS059504 lethal | late embryonic stage dltP1 dltP2 dltP4 lethal | pupal stage dltA1 dltC1 dltO2 lethal | pupal stage (with Df(3L)Aprt-32) dltA1 dltC1 dltdre1 dltN1 dltO2 lethal | pupal stage | recessive dltdre1 lethal | recessive dlt1 dlt2 dlt3 dlt04276 semi-viable, with Scer\GAL4btl.PS dltScer\UAS.cPa semi-viable, with Scer\GAL4dpp.blk1 dltScer\UAS.cPa semi-viable, with Scer\GAL4Kr.PM dltScer\UAS.cPa viable, with Scer\GAL4pnr-MD237 dltGD10856 Other Phenotypes Allele cell size defective, with Scer\GAL4ptc-559.1 dltdsRNA.Scer\UAS decreased cell number, with Scer\GAL4ptc-559.1 dltdsRNA.Scer\UAS increased cell death, with Scer\GAL4ptc-559.1 dltdsRNA.Scer\UAS visible, with Scer\GAL4pnr-MD237 dltGD10856 Phenotype manifest in Allele chaeta, with Scer\GAL4pnr-MD237 dltGD10856 crossvein, with Scer\GAL4ptc-559.1 dltdsRNA.Scer\UAS embryonic/larval salivary gland | embryonic stage dltdre1 eye, with Scer\GAL4ey.PH dltdsRNA.Scer\UAS eye | somatic clone dltN1 dltdre1 eye-antennal disc dltA1 dltC1 follicle cell | somatic clone dltdre1 imaginal disc dltdre1 leg dltS059504 dltdre1 trichogen cell, with Scer\GAL4pnr-MD237 dltGD10856 wing, with Scer\GAL4ptc-559.1 dltdsRNA.Scer\UAS wing disc | somatic clone dltN1 dltdre1 wing hair | supernumerary, with Scer\GAL4ptc-559.1 dltdsRNA.Scer\UAS
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of dlt Class Mutagen Stocks Known lesion dlt04276 P-element activity 1 Yes dltDG39402 P-element activity 1 -- dltNP4500 1 -- dlt1 ethyl methanesulfonate 0 -- dlt2 ethyl methanesulfonate 0 -- dlt3 gamma ray 0 -- dltA1 ethyl methanesulfonate 0 -- dltC1 ethyl methanesulfonate 0 -- dltdre1 hypomorphic allele - genetic evidence 0 Yes dltN1 ethyl methanesulfonate 0 Yes dltO2 ethyl methanesulfonate 0 -- dltP1 P-element activity 0 Yes dltP2 P-element activity 0 Yes dltP4 P-element activity 0 Yes dltS059504 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dlt Class Mutagen Stocks Known lesion dltGD10856 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes dltJF02601 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dltKK100689 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dltdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes dltScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes dltScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dltt9.5 in vitro construct - genomic fragment 0 Yes dltUbi-p63E.PP in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Aprt-1 (Wang et al., 1994) Df(3L)Aprt-12 (Wang et al., 1994) Df(3L)Aprt-13 (Wang et al., 1994) Df(3L)Aprt-16 (Wang et al., 1994) Df(3L)Aprt-26 (Wang et al., 1994) Df(3L)Aprt-32 (Wang et al., 1994) Df(3L)Aprt-46 (Wang et al., 1994) Df(3L)Aprt-47 (Wang et al., 1994) Df(3L)Aprt-54 (Wang et al., 1994) Df(3L)Aprt-56 (Wang et al., 1994) Df(3L)Aprt-61 (Wang et al., 1994) Df(3L)Aprt-66 (Wang et al., 1994) Df(3L)Aprt-72 (Wang et al., 1994) Df(3L)Aprt-87 (Wang et al., 1994) Df(3L)Aprt-88 (Wang et al., 1994) Df(3L)Aprt-92 (Wang et al., 1994) Df(3L)Aprt-100 (Wang et al., 1994) Df(3L)Aprt-105 (Wang et al., 1994) Df(3L)Aprt-106 (Wang et al., 1994) Df(3L)Aprt-108 (Wang et al., 1994) Df(3L)Aprt-110 (Wang et al., 1994) Df(3L)Aprt-112 (Wang et al., 1994) Df(3L)Aprt-122 (Wang et al., 1994) Df(3L)Aprt-126 (Bhat et al., 1999, Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-133 (Wang et al., 1994) Df(3L)Aprt-134 (Wang et al., 1994) Df(3L)Aprt-137 (Wang et al., 1994) Df(3L)Aprt-143 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-148 (Wang et al., 1994) Df(3L)Aprt-151 (Wang et al., 1994) Df(3L)Aprt-152 (Wang et al., 1994) Df(3L)Aprt-156 (Wang et al., 1994) Df(3L)Aprt-159 (Wang et al., 1994) Df(3L)Aprt-162 (Wang et al., 1994) Df(3L)Aprt-163 (Wang et al., 1994) Df(3L)Aprt-165 (Wang et al., 1994) Df(3L)Aprt-166 (Wang et al., 1994) Df(3L)Aprt-167 (Wang et al., 1994) Df(3L)Aprt-169 (Wang et al., 1994) Df(3L)Aprt-177 (Wang et al., 1994) Df(3L)Aprt-181 (Wang et al., 1994) Df(3L)Aprt-184 (Wang et al., 1994) Df(3L)Aprt-192 (Wang et al., 1994) Df(3L)Aprt-193 (Wang et al., 1994) Df(3L)Aprt-194 (Wang et al., 1994) Df(3L)Aprt-199 (Wang et al., 1994) Df(3L)Aprt-201 (Wang et al., 1994) Df(3L)BSC122 (Andrade and Cook, 2005.8.25) Df(3L)BSC127 (Andrade et al., 2005.10.27) Df(3L)MY10 (Bhat et al., 1999, Tanentzapf et al., 2000, Pielage et al., 2003) Df(3L)R-G2 (Lee et al., 1993) Df(3L)R-G5 (Spradling et al., 1999, Lee et al., 1993) Df(3L)R-R2 (Lee et al., 1993) Ts(2Rt;3Rt)Aprt-185 (Wang et al., 1994)
Not disrupted in	Df(3L)Aprt-3 (Wang et al., 1994) Df(3L)Aprt-9 (Wang et al., 1994) Df(3L)Aprt-10 (Wang et al., 1994) Df(3L)Aprt-14 (Wang et al., 1994) Df(3L)Aprt-15 (Wang et al., 1994) Df(3L)Aprt-18 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-19 (Wang et al., 1994) Df(3L)Aprt-21 (Wang et al., 1994) Df(3L)Aprt-24 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-27 (Wang et al., 1994) Df(3L)Aprt-29 (Wang et al., 1994) Df(3L)Aprt-31 (Wang et al., 1994) Df(3L)Aprt-36 (Wang et al., 1994) Df(3L)Aprt-42 (Wang et al., 1994) Df(3L)Aprt-48 (Wang et al., 1994) Df(3L)Aprt-53 (Wang et al., 1994) Df(3L)Aprt-57 (Wang et al., 1994) Df(3L)Aprt-65 (Wang et al., 1994) Df(3L)Aprt-71 (Wang et al., 1994) Df(3L)Aprt-73 (Wang et al., 1994) Df(3L)Aprt-74 (Wang et al., 1994) Df(3L)Aprt-77 (Wang et al., 1994) Df(3L)Aprt-79 (Wang et al., 1994) Df(3L)Aprt-84 (Wang et al., 1994) Df(3L)Aprt-89 (Wang et al., 1994) Df(3L)Aprt-90 (Wang et al., 1994) Df(3L)Aprt-91 (Wang et al., 1994) Df(3L)Aprt-93 (Wang et al., 1994) Df(3L)Aprt-94 (Wang et al., 1994) Df(3L)Aprt-95 (Wang et al., 1994) Df(3L)Aprt-96 (Wang et al., 1994) Df(3L)Aprt-97 (Wang et al., 1994) Df(3L)Aprt-98 (Wang et al., 1994) Df(3L)Aprt-99 (Wang et al., 1994) Df(3L)Aprt-101 (Wang et al., 1994) Df(3L)Aprt-102 (Wang et al., 1994) Df(3L)Aprt-103 (Wang et al., 1994) Df(3L)Aprt-104 (Wang et al., 1994) Df(3L)Aprt-107 (Wang et al., 1994) Df(3L)Aprt-109 (Wang et al., 1994) Df(3L)Aprt-111 (Wang et al., 1994) Df(3L)Aprt-113 (Wang et al., 1994) Df(3L)Aprt-114 (Wang et al., 1994) Df(3L)Aprt-115 (Wang et al., 1994) Df(3L)Aprt-116 (Wang et al., 1994) Df(3L)Aprt-117 (Wang et al., 1994) Df(3L)Aprt-118 (Wang et al., 1994) Df(3L)Aprt-119 (Wang et al., 1994) Df(3L)Aprt-120 (Wang et al., 1994) Df(3L)Aprt-121 (Wang et al., 1994) Df(3L)Aprt-123 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-124 (Wang et al., 1994) Df(3L)Aprt-125 (Wang et al., 1994) Df(3L)Aprt-127 (Wang et al., 1994) Df(3L)Aprt-128 (Wang et al., 1994) Df(3L)Aprt-129 (Wang et al., 1994) Df(3L)Aprt-130 (Wang et al., 1994) Df(3L)Aprt-131 (Wang et al., 1994) Df(3L)Aprt-132 (Wang et al., 1994) Df(3L)Aprt-135 (Wang et al., 1994) Df(3L)Aprt-136 (Wang et al., 1994) Df(3L)Aprt-138 (Wang et al., 1994) Df(3L)Aprt-139 (Wang et al., 1994) Df(3L)Aprt-140 (Wang et al., 1994) Df(3L)Aprt-141 (Wang et al., 1994) Df(3L)Aprt-142 (Wang et al., 1994) Df(3L)Aprt-144 (Wang et al., 1994) Df(3L)Aprt-145 (Wang et al., 1994) Df(3L)Aprt-146 (Wang et al., 1994) Df(3L)Aprt-147 (Wang et al., 1994) Df(3L)Aprt-149 (Wang et al., 1994) Df(3L)Aprt-150 (Wang et al., 1994) Df(3L)Aprt-153 (Wang et al., 1994) Df(3L)Aprt-154 (Wang et al., 1994) Df(3L)Aprt-157 (Wang et al., 1994) Df(3L)Aprt-158 (Wang et al., 1994) Df(3L)Aprt-160 (Wang et al., 1994) Df(3L)Aprt-161 (Wang et al., 1994) Df(3L)Aprt-164 (Wang et al., 1994) Df(3L)Aprt-168 (Wang et al., 1994) Df(3L)Aprt-170 (Wang et al., 1994) Df(3L)Aprt-171 (Wang et al., 1994) Df(3L)Aprt-172 (Wang et al., 1994) Df(3L)Aprt-173 (Wang et al., 1994) Df(3L)Aprt-174 (Wang et al., 1994) Df(3L)Aprt-178 (Wang et al., 1994) Df(3L)Aprt-179 (Wang et al., 1994) Df(3L)Aprt-180 (Wang et al., 1994) Df(3L)Aprt-182 (Wang et al., 1994) Df(3L)Aprt-183 (Wang et al., 1994) Df(3L)Aprt-186 (Wang et al., 1994) Df(3L)Aprt-187 (Wang et al., 1994) Df(3L)Aprt-188 (Wang et al., 1994) Df(3L)Aprt-189 (Wang et al., 1994) Df(3L)Aprt-190 (Wang et al., 1994) Df(3L)Aprt-191 (Wang et al., 1994) Df(3L)Aprt-195 (Wang et al., 1994) Df(3L)Aprt-196 (Wang et al., 1994) Df(3L)Aprt-198 (Wang et al., 1994) Df(3L)Ar14-8 (Spradling et al., 1999) Df(3L)R-E (Lee et al., 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10856} NA P{KK100689} NA P{TRiP.JF02601} NA P{UAS-dlt.dsRNA} NA P{UAS-dlt.Myc} NA P{UAS-dlt.P} NA P{UAS-Patj.B} NA characterization construct P{COSMY1-1} NA P{COSMY8-1} NA P{PatjEHHS} NA P{PatjEΔHS} NA P{PatjSHS} NA P{PatjSΔHS} NA P{Ubi-dlt.P} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}dltS059504 No P{PZ}dlt04276 No insertion of enhancer trap binary system P{GawB}dltNP4500 No miscellaneous insertions P{wHy}α-SpecDG39402 NA PBac{PB}α-Specc03367 NA PBac{RB}α-Spece01361 NA insertion of mobile activating element P{EP}dltP1 NA P{EP}dltP2 NA P{EP}dltP4 NA P{XP}α-Specd03930 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data on: 2006-10-26)
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cellular process inferred from mutant phenotype (Pielage et al., 2003) imaginal disc morphogenesis inferred from mutant phenotype (assigned by UniProtKB) (Pielage et al., 2003) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) olfactory behavior inferred from expression pattern (Fanara et al., 2002) inferred from mutant phenotype (Anholt et al., 2002) regulation of cell proliferation inferred from mutant phenotype (assigned by UniProtKB) (Pielage et al., 2003) S phase of mitotic cell cycle inferred from mutant phenotype (assigned by UniProtKB) (Pielage et al., 2003)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (assigned by UniProtKB) (Pielage et al., 2003)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
morphogenesis of a polarized epithelium traceable author statement (Gibson and Perrimon, 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_dicistronic_primary_transcript (FlyBase Genome Annotators, 2002-2003) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dlt allele Gene References dltdsRNA.Scer\UAS CycE (Pielage et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70341 DroID - A comprehensive database of gene and protein interactions. • FBgn0024510 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46719
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24961 Dere\GG14559 Dgri\GH15716 Dmoj\GI12772 Dper\GL16207 Dpse\GA16826 Dsec\GM14168 Dsim\GD13437 Dvir\GJ16070 Dwil\GK20503 Dyak\GE20914
Curated drosophilid orthologs	Dpse\GA11344   Dpse\GA16826
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004917-PA Aedes aegypti (mosquito) AGAP010055-PA Anopheles gambiae (mosquito) 73707 Branchiostoma floridae (lancelet) 73725 Branchiostoma floridae (lancelet) BGIBMGA011154-PA Bombyx mori (silk worm) ENSBTAP00000007561 Bos taurus (bovine) ENSCAFP00000016457 Canis familiaris (dog) ENSCPOP00000011878 Cavia porcellus (guinea pig) 326470 Daphnia pulex (daphnia) ENSDARP00000061960 Danio rerio (zebra fish) ENSECAP00000012881 Equus caballus (horse) ENSGACP00000014729 Gymnopilus aculeatus (mushroom) ENSGALP00000014899 Gallus gallus (chicken) ENSP00000348564 Homo sapiens (human) ISCW017093-PA Ixodes scapularis (deer tick) ENSMODP00000022281 Monodelphis domestica (gray opossum) ENSMMUP00000019830 Macaca mulatta (rhesus monkey) 239689 Nematostella vectensis (starlet anemone) XP_001601592.1 Nasonia vitripennis (wasp) ENSOANP00000018114 Ornithorynchus anatinus (platypus) ENSORLP00000014104 Oryzias latipes (japanese killifish) PHUM009298-PA Pediculus humanus (human body louse) ENSPPYP00000007255 Pongo pygmaeus (orangutan) ENSPTRP00000046824 Pan troglodytes (chimpanzee) ENSRNOP00000014664 Rattus norvegicus (norway rat) XP_001178126.1 Strongylocentrotus purpuratus (purple sea urchin) 59849 Trichoplax adhaerens (metazoa) XP_972528.2 Tribolium castaneum (red flour beetle) ENSTNIP00000000753 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000025071 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16310 NV18942 LH12183 ISCW017093 FBgn0238202 FBgn0222500 FBgn0203255 FBgn0185149 FBgn0169094 JGI_V11_326470 FBgn0076840 FBgn0153811 FBgn0135529 FBgn0123187 FBgn0106816 FBgn0101953 CPIJ016913 BGIBMGA011154 ACYPI005396 GB30554 GB14173 AGAP010055 AAEL004917 PHUM405140 GLEAN_15308
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	27288 y1 v1; P{TRiP.JF02601}attP2 10160 P{PZ}dlt04276 α-Spec04276 ry506/TM6B, Tb1 21780 y1 w67c23; P{wHy}α-SpecDG39402 dltDG39402
Kyoto	104700 y* w*; P{GawB}dltNP4500 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v103709 P{KK100689}VIE-260B v41876 w1118; P{GD10856}v41876 v45459 w1118; P{GD10856}v45459 v41875 w1118; P{GD10856}v41875/TM3
Genomic Clones ( 1 )
	BACR10D15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 30 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD29802
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07727 AT09864 AT30785 LD04447 LD04636 LD11230 LD15747 LD17359 LD18420 LD20272 LD20280 LD20806 LD30380 LP17368 RE14950 RE59169 RE72131 RH58622
Other clones	38353 77021 118000 214221.28 214385.24 Dmel_neb_010751_0649_2808 EK151617 EK154807 EP01353 EP12003 LD15712
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024510 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46719
Antibody Information
	polyclonal (Bhat et al., 1999)
Other Information
Discoverer
Etymology
	The gene is named "Vanaso" since segregation of putative alleles in Oregon and 2b strains causes additive genetic variance (V[[A]]) in olfactory avoidance behaviour ("naso" is a Spanish term for nose). (Fanara et al., 2002)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Vanaso CG32315 (FlyBase Genome Annotators, 2002-2003) Source for identity of: Van l(3)04276 (Anholt et al., 2002)
Source for database merge of	Source for merge of: dlt l(3)62Ba (Bhat et al., 1999)
Additional comments	The "dre1/dlt" complementation group corresponds to the CG32315 gene and not to CG12021. It was previously reported in FBrf0107610 that the relevant locus for the "dre1" (dlt) complementation group was CG12021, based on mapping and complementation data (shown in Figure 4. of FBrf0107610). However, it has recently been shown (FBrf0167484) that "dre1" is allelic to CG32315 rather than CG12021. Re-evaluation of the "dre1" mutation indicates that the chromosome carries a T516S amino acid change in CG12021 and a stop codon at position 865 in CG32315. Since the mutation in CG12021 is conservative, it may not underlie the loss of imaginal discs observed in "dre1" mutants, and instead, the "dre1" mutant phenotypes described in FBrf0107610 are likely due to the mutation in CG32315. This is also supported by the observation that the P{PatjEHHS} construct (Figure 4 of FBrf0107610) now fails to rescue the "dre1" mutation. In addition, the "dre1" mutation fails to complement an allele in CG32315 ("Van04276"), clearly implicating CG32315 as causing the lethality associated with "dre1". It remains possible that the "dre1" phenotypes shown in Figure 6 of FBrf0107610 may result from a combination of mutations in both genes. Overexpression of CG12021 causes a severe loss of epithelial polarity as shown in Figure 7. of FBrf0107610. FlyBase curator comment: the T516S amino acid change in CG12021 on the "dre1" chromosome is represented by the allele Patjdre1 and the stop codon at position 865 in CG32315 on the "dre1" chromosome is represented by the allele dltdre1. (Bhat et al., 2003) The dlt phenotype maps to the CG32315 annotation, not the CG12021 annotation, as was reported previously (FBrf0107610). (Klaembt, 2003.10.31) The P-element induced alleles dltP1, dltP2 and dltP4 do not complement mutations in α-Spec. (Pielage et al., 2003) One or more of the processed transcripts for this gene share(s) untranslated sequences with a transcript of an adjacent gene, but encode(s) a single open reading frame (ORF). The non-overlapping ORFs that share untranslated sequences are represented by dlt and α-Spec. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	The dlt open reading frame is located within the first intron of α-Spec and the two genes share a common first untranslated exon. Overall orientation not stated: Patj- CG12020- Cdc37- α-Spec+ dlt+ α-Spec+ (Pielage et al., 2003) Identification: as a female-specific quantitative trait locus affecting variation in olfactory avoidance response to benzaldehyde. (Anholt et al., 2002) dlt is expressed exclusively in the third antennal segment. (Anholt et al., 2002) Mutations cause pupal lethality with third instar larvae devoid of imaginal discs. (Bhat et al., 1998) Recessive lethal mutations in this complementation group were identified by failure to complement the recessive lethality of Df(3L)R-R2. (Sliter et al., 1989) FlyBase curator comment: The gene corresponding to genome annotation CG12021 was named "dlt:discs lost" in FBrf0107610. Subsequently the "dlt" phenotype was shown to map not to CG12021, but to the gene corresponding to genome annotation CG32315. Consequently the "dlt:discs lost" name was moved to CG32315, and the name of the gene for CG12021 was changed to "Patj". See Klaembt, 2003.10.31, personal communication to FlyBase
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_167916 RefSeq (Proteins) • NP_728672 DDBJ / EMBL / GenBank • AA949786 AAF47570 AAK93194 AAM18043 AAM18044 AF487673 AF487674 AF487675 AF487676 AF487677 AF487678 AQ026196 AW942985 AY051770 Entrez Gene - A searchable database of RefSeq genes. • 46719 UniProtKB/Swiss-Prot • Q8T626
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Regulator of chromosome condensation, RCC1 (IPR000408)
Linkouts
	BioGRID - A database of protein and genetic interactions • 70341 DroID - A comprehensive database of gene and protein interactions. • FBgn0024510 DRSC - Results from RNAi screens. • FBgn0024510 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024510 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32315-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024510 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46719 InParanoid A subset of ortholog calls from InParanoid. • AAEL004917-PA Aedes aegypti (mosquito) AGAP010055-PA Anopheles gambiae (mosquito) 73707 Branchiostoma floridae (lancelet) 73725 Branchiostoma floridae (lancelet) BGIBMGA011154-PA Bombyx mori (silk worm) ENSBTAP00000007561 Bos taurus (bovine) ENSCAFP00000016457 Canis familiaris (dog) ENSCPOP00000011878 Cavia porcellus (guinea pig) 326470 Daphnia pulex (daphnia) ENSDARP00000061960 Danio rerio (zebra fish) ENSECAP00000012881 Equus caballus (horse) ENSGACP00000014729 Gymnopilus aculeatus (mushroom) ENSGALP00000014899 Gallus gallus (chicken) ENSP00000348564 Homo sapiens (human) ISCW017093-PA Ixodes scapularis (deer tick) ENSMODP00000022281 Monodelphis domestica (gray opossum) ENSMMUP00000019830 Macaca mulatta (rhesus monkey) 239689 Nematostella vectensis (starlet anemone) XP_001601592.1 Nasonia vitripennis (wasp) ENSOANP00000018114 Ornithorynchus anatinus (platypus) ENSORLP00000014104 Oryzias latipes (japanese killifish) PHUM009298-PA Pediculus humanus (human body louse) ENSPPYP00000007255 Pongo pygmaeus (orangutan) ENSPTRP00000046824 Pan troglodytes (chimpanzee) ENSRNOP00000014664 Rattus norvegicus (norway rat) XP_001178126.1 Strongylocentrotus purpuratus (purple sea urchin) 59849 Trichoplax adhaerens (metazoa) XP_972528.2 Tribolium castaneum (red flour beetle) ENSTNIP00000000753 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000025071 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/disclst1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46719 modMine - Data generated by the modENCODE project. • FBgn0024510 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16310 NV18942 LH12183 ISCW017093 FBgn0238202 FBgn0222500 FBgn0203255 FBgn0185149 FBgn0169094 JGI_V11_326470 FBgn0076840 FBgn0153811 FBgn0135529 FBgn0123187 FBgn0106816 FBgn0101953 CPIJ016913 BGIBMGA011154 ACYPI005396 GB30554 GB14173 AGAP010055 AAEL004917 PHUM405140 GLEAN_15308
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG1977 (Whitfield, 2001.2.21, ) CG32315 (Pielage et al., 2003, Bhat et al., 2003, Keleman et al., 2009.8.5) dlt (Richard et al., 2006, Djiane et al., 2005, Sandmann et al., 2007, Nam and Choi, 2006, Perkins et al., 2009.8.10, Wasbrough et al., 2010) Dlt (Spasić et al., 2008) dre1 (Machado and Andrew, 2000, Bhat et al., 1999) l(3)62Ba (Lindsley and Zimm, 1992, ) l(3)04276 (Fanara et al., 2002, Anholt et al., 2002, Spradling et al., 1999, ) l(3)dre1 (Sliter et al., 1989, Lindsley and Zimm, 1992, Lee et al., 1993, ) Van (Mackay et al., 2005, Fanara et al., 2002, )
Name Synonym	discs lost (Bhat et al., 2003, Richard et al., 2006) lethal(3)62Ba   Vanaso (Mackay, 2004, Bhat et al., 2003, Fanara et al., 2002, Giot et al., 2003, Harbison et al., 2005) vanaso (Pielage et al., 2003)
Secondary FlyBase IDs
	FBgn0052315 FBgn0064128
References ( 51 )
Generate a list of	All references relating to this gene ( 51 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 3 ) Review  ( 4 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 4 ) FlyBase analysis  ( 4 ) Book  ( 1 ) Computer file  ( 3 )
Recent research papers ( 1 )
	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...