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Gene Dmel\flfl

General Information
Symbol	Dmel\flfl	Species	D. melanogaster
Name	falafel	Annotation symbol	CG9351
Feature type	protein_coding_gene	FlyBase ID	FBgn0024555
Gene Model Status	Current	Stock availability	11 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	87F10-87F11	Sequence location	3R:9,509,680..9,519,629 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene falafel is referred to in FlyBase by the symbol Dmel\flfl (CG9351, FBgn0024555). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: Rac protein signal transduction; dorsal closure; neuroblast proliferation; asymmetric neuroblast division; asymmetric protein localization; phagocytosis, engulfment. 23 alleles are reported. The phenotypes of these alleles are annotated with: neuroblast; mesothoracic tergum; wing; cell; wing vein. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Domain of unknown function DUF625; Pleckstrin homology-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult salivary gland, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637302_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of flfl. Gene sequence location is 3R:9509680..9519629.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN22863 HFA16474
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87F10-87F11   Limits computationally determined from genome sequence between P{lacW}B52s2249&P{lacW}flflL4179 and P{PZ}flfl01949
Experimentally Determined Cytological Location
Cytogenetic map Notes References 87F7-87F8   (determined by in situ hybridisation)   (Spradling et al., 1999) 87F7-87F8     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\flfl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone appears problematic (LD26904): incomplete CDS; DGC:LD13350 okay.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) flfl-RB FBtr0082817  NM_169548   5604   980 flfl-RD FBtr0114604  NM_142047   5583   973
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein flfl-PB   FBpp0082285   109.3   980   4.42     NP_731849   AAN13587 flfl-PD   FBpp0113096   108.6   973   4.40     NP_650304   AAF54974
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Domain of unknown function DUF625 (IPR006887) Pleckstrin homology-type (IPR011993)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141036   AA141037   AA438950   AA539655   AA539707   AA820514   AA942589   AE014297 AAF54974   AE014297 AAN13587   AQ026264   AW942267   AW942861   AY118508 AAM49877   AY118536 AAM49905   BF485880   BF503353   BG633309   BG636938   BG638150   BG638403   BI214219   BP558206   BP558207   CK657509   CL632141   CO185578   CO188849   CO189397   CO189708   CO262714   CO270457   CO273390   CO274034   CO277296   CO277943   CO279474   CO286160   CO289822   CO290405   CO291392   CO302773   CO302832   CO305175   CO312186   CO315433   CO319882   CO322546   CO322799   CO324534   CO324574   CO329517   CO330343   CO332545   CO333158   CO333168   CZ475783   EC057832   EC058847   EC059147   EC059430   EC059431   EC060893   EC063001   EC064815   EC067340   EC067414   EC067920   EC074480   EC074565   EC084379   EC085414   EC087011   EC087457   EC090997   EC195753   EC197775   EC198309   EC200594   EC205958   EC208644   EC212165   EC218538   EC221420   EC221892   EC226278   EC228636   EC228935   EC228936   EC229108   EC229851   EC230358   EC231100   EC232496   EC235804   EC243928   EC246745   EC250977   EC251148   EC251221   EL881210   GH941981   GH942176   GH943650   GH944106   GH946849   GH946877   GH946898   GH947169   GH947329   GH947408   GH947509   GH948190   GH948401   GH948609   GH948660   GH949879   GH949997   GH950775   GH950782   GH950809   GH951293   GH951846   GH951959   GH952479   GH954303   GH955059   GH956613   GH958466   GH960252   GH960552   GH963397   GH963849   GH964642   GH964956   GH966102   GH966192   GH967552   GH967625   GH968179   GH968646   GH968995   GH970100   GH971794   GH972819   GH973242   GH973953   GH974768   GH974809   GH977154   GH979225   GH980227   GH980805   GH983709   GH983999
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MSW1 Q9VFS5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0024555    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0024555 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0024555 expression level Developmental Stage   Expression Level embryo 00-02hr    4637 embryo 02-04hr    7225 embryo 04-06hr    5482 embryo 06-08hr    4549 embryo 08-10hr    4148 embryo 10-12hr    2185 embryo 12-14hr    2895 embryo 14-16hr    2129 embryo 16-18hr    1905 embryo 18-20hr    1275 embryo 20-22hr    2266 embryo 22-24hr    2209 larva L1    990 larva L2    850 larva L3 12hr old    673 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    1568 larva L3 puffstage 7-9    2204 white prepupae new    2308 white prepupae 12hr    2332 white prepupae 24hr    2750 pupae 2d postWPP    2087 pupae 3d postWPP    1179 pupae 4d postWPP    977 adult male 01day    1267 adult male 05day    1293 adult male 30day    1198 adult female 01day    1507 adult female 05day    2490 adult female 30day    2548 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4637) embryo 02-04hr  (7225) embryo 04-06hr  (5482) embryo 06-08hr  (4549) embryo 08-10hr  (4148) embryo 10-12hr  (2185) embryo 12-14hr  (2895) embryo 14-16hr  (2129) embryo 16-18hr  (1905) embryo 18-20hr  (1275) embryo 20-22hr  (2266) embryo 22-24hr  (2209) larva L1  (990) larva L2  (850) larva L3 12hr old  (673) larva L3 puffstage 1-2  (701) larva L3 puffstage 3-6  (1568) larva L3 puffstage 7-9  (2204) white prepupae new  (2308) white prepupae 12hr  (2332) white prepupae 24hr  (2750) pupae 2d postWPP  (2087) pupae 3d postWPP  (1179) pupae 4d postWPP  (977) adult male 01day  (1267) adult male 05day  (1293) adult male 30day  (1198) adult female 01day  (1507) adult female 05day  (2490) adult female 30day  (2548) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4637) embryo 02-04hr  (7225) embryo 04-06hr  (5482) embryo 06-08hr  (4549) embryo 08-10hr  (4148) embryo 10-12hr  (2185) embryo 12-14hr  (2895) embryo 14-16hr  (2129) embryo 16-18hr  (1905) embryo 18-20hr    1275 embryo 20-22hr  (2266) embryo 22-24hr  (2209) larva L1    990 larva L2    850 larva L3 12hr old    673 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6  (1568) larva L3 puffstage 7-9  (2204) white prepupae new  (2308) white prepupae 12hr  (2332) white prepupae 24hr  (2750) pupae 2d postWPP  (2087) pupae 3d postWPP    1179 pupae 4d postWPP    977 adult male 01day    1267 adult male 05day    1293 adult male 30day    1198 adult female 01day  1507 adult female 05day  (2490) adult female 30day  (2548) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4637 embryo 02-04hr    7225 embryo 04-06hr    5482 embryo 06-08hr    4549 embryo 08-10hr    4148 embryo 10-12hr    2185 embryo 12-14hr    2895 embryo 14-16hr    2129 embryo 16-18hr    1905 embryo 18-20hr    1275 embryo 20-22hr    2266 embryo 22-24hr    2209 larva L1    990 larva L2    850 larva L3 12hr old    673 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    1568 larva L3 puffstage 7-9    2204 white prepupae new    2308 white prepupae 12hr    2332 white prepupae 24hr    2750 pupae 2d postWPP    2087 pupae 3d postWPP    1179 pupae 4d postWPP    977 adult male 01day    1267 adult male 05day    1293 adult male 30day    1198 adult female 01day    1507 adult female 05day    2490 adult female 30day    2548 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4637 embryo 02-04hr    7225 embryo 04-06hr    5482 embryo 06-08hr    4549 embryo 08-10hr    4148 embryo 10-12hr    2185 embryo 12-14hr    2895 embryo 14-16hr    2129 embryo 16-18hr    1905 embryo 18-20hr    1275 embryo 20-22hr    2266 embryo 22-24hr    2209 larva L1    990 larva L2    850 larva L3 12hr old    673 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    1568 larva L3 puffstage 7-9    2204 white prepupae new    2308 white prepupae 12hr    2332 white prepupae 24hr    2750 pupae 2d postWPP    2087 pupae 3d postWPP    1179 pupae 4d postWPP    977 adult male 01day    1267 adult male 05day    1293 adult male 30day    1198 adult female 01day    1507 adult female 05day    2490 adult female 30day    2548 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0024555 expression level Developmental Stage   Expression Level embryo 00-02hr    4637 embryo 02-04hr    7225 embryo 04-06hr    5482 embryo 06-08hr    4549 embryo 08-10hr    4148 embryo 10-12hr    2185 embryo 12-14hr    2895 embryo 14-16hr    2129 embryo 16-18hr    1905 embryo 18-20hr    1275 embryo 20-22hr    2266 embryo 22-24hr    2209 larva L1    990 larva L2    850 larva L3 12hr old    673 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    1568 larva L3 puffstage 7-9    2204 white prepupae new    2308 white prepupae 12hr    2332 white prepupae 24hr    2750 pupae 2d postWPP    2087 pupae 3d postWPP    1179 pupae 4d postWPP    977 adult male 01day    1267 adult male 05day    1293 adult male 30day    1198 adult female 01day    1507 adult female 05day    2490 adult female 30day    2548 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4637) embryo 02-04hr  (7225) embryo 04-06hr  (5482) embryo 06-08hr  (4549) embryo 08-10hr  (4148) embryo 10-12hr  (2185) embryo 12-14hr  (2895) embryo 14-16hr  (2129) embryo 16-18hr  (1905) embryo 18-20hr  (1275) embryo 20-22hr  (2266) embryo 22-24hr  (2209) larva L1  (990) larva L2  (850) larva L3 12hr old  (673) larva L3 puffstage 1-2  (701) larva L3 puffstage 3-6  (1568) larva L3 puffstage 7-9  (2204) white prepupae new  (2308) white prepupae 12hr  (2332) white prepupae 24hr  (2750) pupae 2d postWPP  (2087) pupae 3d postWPP  (1179) pupae 4d postWPP  (977) adult male 01day  (1267) adult male 05day  (1293) adult male 30day  (1198) adult female 01day  (1507) adult female 05day  (2490) adult female 30day  (2548) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4637) embryo 02-04hr  (7225) embryo 04-06hr  (5482) embryo 06-08hr  (4549) embryo 08-10hr  (4148) embryo 10-12hr  2185 embryo 12-14hr  (2895) embryo 14-16hr  2129 embryo 16-18hr  1905 embryo 18-20hr    1275 embryo 20-22hr  2266 embryo 22-24hr  2209 larva L1    990 larva L2    850 larva L3 12hr old    673 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6  1568 larva L3 puffstage 7-9  2204 white prepupae new  2308 white prepupae 12hr  2332 white prepupae 24hr  (2750) pupae 2d postWPP  2087 pupae 3d postWPP    1179 pupae 4d postWPP    977 adult male 01day    1267 adult male 05day    1293 adult male 30day    1198 adult female 01day  1507 adult female 05day  (2490) adult female 30day  (2548) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4637 embryo 02-04hr    7225 embryo 04-06hr    5482 embryo 06-08hr    4549 embryo 08-10hr    4148 embryo 10-12hr    2185 embryo 12-14hr    2895 embryo 14-16hr    2129 embryo 16-18hr    1905 embryo 18-20hr    1275 embryo 20-22hr    2266 embryo 22-24hr    2209 larva L1    990 larva L2    850 larva L3 12hr old    673 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    1568 larva L3 puffstage 7-9    2204 white prepupae new    2308 white prepupae 12hr    2332 white prepupae 24hr    2750 pupae 2d postWPP    2087 pupae 3d postWPP    1179 pupae 4d postWPP    977 adult male 01day    1267 adult male 05day    1293 adult male 30day    1198 adult female 01day    1507 adult female 05day    2490 adult female 30day    2548 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4637 embryo 02-04hr    7225 embryo 04-06hr    5482 embryo 06-08hr    4549 embryo 08-10hr    4148 embryo 10-12hr    2185 embryo 12-14hr    2895 embryo 14-16hr    2129 embryo 16-18hr    1905 embryo 18-20hr    1275 embryo 20-22hr    2266 embryo 22-24hr    2209 larva L1    990 larva L2    850 larva L3 12hr old    673 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    1568 larva L3 puffstage 7-9    2204 white prepupae new    2308 white prepupae 12hr    2332 white prepupae 24hr    2750 pupae 2d postWPP    2087 pupae 3d postWPP    1179 pupae 4d postWPP    977 adult male 01day    1267 adult male 05day    1293 adult male 30day    1198 adult female 01day    1507 adult female 05day    2490 adult female 30day    2548 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0024555    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0024555 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult salivary gland, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0024555 expression level Tissue   Expression Level Larval Central Nervous System    1123.3 Larval Midgut    235.6 Larval Hindgut    373.9 Larval Malpighian Tubules    372.3 Larval Fat Body    238.3 Larval Salivary Gland    342.1 Larval Trachea    626.35 Larval Carcass    336.75 Adult Head    385.6 Adult Eye    445.05 Adult Brain    841.5 Adult Thoracic-Abdominal Ganglion    689.5 Adult Crop    504.9 Adult Midgut    363.2 Adult Hindgut    483.9 Adult Malpighian Tubules    425.8 Adult Fat Body    309.8 Adult Salivary Gland    637.2 Adult Heart    327.525 Adult VirginFemale Spermatheca    342.1 Adult InseminatedFemale Spermatheca    419 Adult Ovary    175.9 Adult Testis    47.7 Adult Male Accessory Gland    479.6 Adult Carcass    210.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1123.3) Larval Midgut    235.6 Larval Hindgut    373.9 Larval Malpighian Tubules    372.3 Larval Fat Body    238.3 Larval Salivary Gland    342.1 Larval Trachea  (626.35) Larval Carcass    336.75 Adult Head    385.6 Adult Eye    445.05 Adult Brain  (841.5) Adult Thoracic-Abdominal Ganglion  (689.5) Adult Crop  504.9 Adult Midgut    363.2 Adult Hindgut    483.9 Adult Malpighian Tubules    425.8 Adult Fat Body    309.8 Adult Salivary Gland  (637.2) Adult Heart    327.525 Adult VirginFemale Spermatheca    342.1 Adult InseminatedFemale Spermatheca    419 Adult Ovary    175.9 Adult Testis    47.7 Adult Male Accessory Gland    479.6 Adult Carcass    210.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1123.3) Larval Midgut    235.6 Larval Hindgut    373.9 Larval Malpighian Tubules    372.3 Larval Fat Body    238.3 Larval Salivary Gland    342.1 Larval Trachea    626.35 Larval Carcass    336.75 Adult Head    385.6 Adult Eye    445.05 Adult Brain    841.5 Adult Thoracic-Abdominal Ganglion    689.5 Adult Crop    504.9 Adult Midgut    363.2 Adult Hindgut    483.9 Adult Malpighian Tubules    425.8 Adult Fat Body    309.8 Adult Salivary Gland    637.2 Adult Heart    327.525 Adult VirginFemale Spermatheca    342.1 Adult InseminatedFemale Spermatheca    419 Adult Ovary    175.9 Adult Testis    47.7 Adult Male Accessory Gland    479.6 Adult Carcass    210.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1123.3 Larval Midgut    235.6 Larval Hindgut    373.9 Larval Malpighian Tubules    372.3 Larval Fat Body    238.3 Larval Salivary Gland    342.1 Larval Trachea    626.35 Larval Carcass    336.75 Adult Head    385.6 Adult Eye    445.05 Adult Brain    841.5 Adult Thoracic-Abdominal Ganglion    689.5 Adult Crop    504.9 Adult Midgut    363.2 Adult Hindgut    483.9 Adult Malpighian Tubules    425.8 Adult Fat Body    309.8 Adult Salivary Gland    637.2 Adult Heart    327.525 Adult VirginFemale Spermatheca    342.1 Adult InseminatedFemale Spermatheca    419 Adult Ovary    175.9 Adult Testis    47.7 Adult Male Accessory Gland    479.6 Adult Carcass    210.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0024555 expression level Tissue   Expression Level Larval Central Nervous System    1123.3 Larval Midgut    235.6 Larval Hindgut    373.9 Larval Malpighian Tubules    372.3 Larval Fat Body    238.3 Larval Salivary Gland    342.1 Larval Trachea    626.35 Larval Carcass    336.75 Adult Head    385.6 Adult Eye    445.05 Adult Brain    841.5 Adult Thoracic-Abdominal Ganglion    689.5 Adult Crop    504.9 Adult Midgut    363.2 Adult Hindgut    483.9 Adult Malpighian Tubules    425.8 Adult Fat Body    309.8 Adult Salivary Gland    637.2 Adult Heart    327.525 Adult VirginFemale Spermatheca    342.1 Adult InseminatedFemale Spermatheca    419 Adult Ovary    175.9 Adult Testis    47.7 Adult Male Accessory Gland    479.6 Adult Carcass    210.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1123.3) Larval Midgut    235.6 Larval Hindgut    373.9 Larval Malpighian Tubules    372.3 Larval Fat Body    238.3 Larval Salivary Gland    342.1 Larval Trachea  626.35 Larval Carcass    336.75 Adult Head    385.6 Adult Eye    445.05 Adult Brain  (841.5) Adult Thoracic-Abdominal Ganglion  689.5 Adult Crop  504.9 Adult Midgut    363.2 Adult Hindgut    483.9 Adult Malpighian Tubules    425.8 Adult Fat Body    309.8 Adult Salivary Gland  637.2 Adult Heart    327.525 Adult VirginFemale Spermatheca    342.1 Adult InseminatedFemale Spermatheca    419 Adult Ovary    175.9 Adult Testis    47.7 Adult Male Accessory Gland    479.6 Adult Carcass    210.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1123.3 Larval Midgut    235.6 Larval Hindgut    373.9 Larval Malpighian Tubules    372.3 Larval Fat Body    238.3 Larval Salivary Gland    342.1 Larval Trachea    626.35 Larval Carcass    336.75 Adult Head    385.6 Adult Eye    445.05 Adult Brain    841.5 Adult Thoracic-Abdominal Ganglion    689.5 Adult Crop    504.9 Adult Midgut    363.2 Adult Hindgut    483.9 Adult Malpighian Tubules    425.8 Adult Fat Body    309.8 Adult Salivary Gland    637.2 Adult Heart    327.525 Adult VirginFemale Spermatheca    342.1 Adult InseminatedFemale Spermatheca    419 Adult Ovary    175.9 Adult Testis    47.7 Adult Male Accessory Gland    479.6 Adult Carcass    210.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1123.3 Larval Midgut    235.6 Larval Hindgut    373.9 Larval Malpighian Tubules    372.3 Larval Fat Body    238.3 Larval Salivary Gland    342.1 Larval Trachea    626.35 Larval Carcass    336.75 Adult Head    385.6 Adult Eye    445.05 Adult Brain    841.5 Adult Thoracic-Abdominal Ganglion    689.5 Adult Crop    504.9 Adult Midgut    363.2 Adult Hindgut    483.9 Adult Malpighian Tubules    425.8 Adult Fat Body    309.8 Adult Salivary Gland    637.2 Adult Heart    327.525 Adult VirginFemale Spermatheca    342.1 Adult InseminatedFemale Spermatheca    419 Adult Ovary    175.9 Adult Testis    47.7 Adult Male Accessory Gland    479.6 Adult Carcass    210.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    385.6   NA  Eye    445.05   NA  Brain    841.5   1123.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    689.5   NA  Crop    504.9   235.6  Midgut    363.2   373.9  Hindgut    483.9   372.3  Malpighian Tubules    425.8   238.3  Fat Body    309.8   342.1  Salivary Gland    637.2   NA  Heart    327.525   626.35  Trachea    NA   NA  VirginFemale Spermatheca    342.1   NA  InseminatedFemale Spermatheca    419   NA  Ovary    175.9   NA  Testis    47.7   NA  Male Accessory Gland    479.6   336.75  Carcass    210.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024555 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9351-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for flfl Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage flflN42 lethal | pharate adult stage flfl795 lethal | recessive flflL4179 lethal | third instar larval stage (with Df(3R)Exel6170) flfl795 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 flflGD14196 viable flflEY03622 Sterility Allele female fertile | poor (with Df(3R)ED5622) flflL4179 fertile flflEY03622 Other Phenotypes Allele cell cycle defective, with Scer\GAL41407 flflfl.Scer\UAS.T:Avic\GFP-YFP.Venus,T:Hsap\CAAX decreased cell number (with Df(3R)Exel6170) flflN42 visible, with Scer\GAL4pnr-MD237 flflGD14196 Phenotype manifest in Allele cell flflfl.Scer\UAS.T:Avic\GFP-YFP.Venus,T:Hsap\CAAX mesothoracic tergum, with Scer\GAL4pnr-MD237 flflGD14196 neuroblast (with Df(3R)Exel6170) flflN42 wing (with Df(3R)ED5622) flflL4179 wing vein (with Df(3R)ED5622) flflL4179
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of flfl Class Mutagen Stocks Known lesion flfld07513 P-element activity 1 -- flflDG29504 P-element activity 1 -- flflEY03585 P-element activity 1 Yes flflEY03622 P-element activity 1 Yes flflGS9037 1 Yes flflL4179 P-element activity 1 Yes flfl01949 P-element activity 0 Yes flfl795-2 ethyl methanesulfonate 0 Yes flfl795-3 ethyl methanesulfonate 0 Yes flfl795 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes flflCB05447 P-element activity 0 Yes flflGS8059 0 -- flflN42 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of flfl Class Mutagen Stocks Known lesion flflGD14196 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes flflHMS00247 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes flflJF01896 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes flflJF02802 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes flflKK102767 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes flflfl.Scer\UAS.T:Avic\GFP-YFP.Venus,T:Hsap\CAAX in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes flflfl.Scer\UAS.T:Avic\GFP-YFP.Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes flflΔ3xNLS.Scer\UAS.T:Avic\GFP-YFP.Venus,T:Uuuu\nls6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes flflΔ3xNLS.Scer\UAS.T:Avic\GFP-YFP.Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes flflΔNLS3.Scer\UAS.T:Avic\GFP-YFP.Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3R)red3l (Spradling et al., 1999)
Disrupted in	Df(3R)Exel6170 (Sousa-Nunes et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14196} NA P{KK102767} NA P{TRiP.HMS00247} NA P{TRiP.JF01896} NA P{TRiP.JF02802} NA P{UAS-Venus-flfl.Δ3NLS} NA P{UAS-Venus-flfl.Δ3NLS+2NES} NA P{UAS-Venus-flfl.ΔNLS3} NA P{UAS-Venus-flfl} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}flflL4179 No P{PZ}flfl01949 No insertion of mobile activating element P{EPgy2}flflEY03585 NA P{EPgy2}omdEY03622 NA P{GSV3}flflGS8059 NA P{GSV6}flflGS9037 NA P{XP}flfld07513 NA miscellaneous insertions P{PTT-GB}flflCB05447 NA P{wHy}flflDG29504 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with mira (Sousa-Nunes et al., 2009)
Biological Process
CV term Evidence References
asymmetric neuroblast division inferred from mutant phenotype (Sousa-Nunes et al., 2009) asymmetric protein localization inferred from mutant phenotype (Sousa-Nunes et al., 2009) dorsal closure inferred from mutant phenotype (Zarske and Hafen, 2003) neuroblast proliferation inferred from mutant phenotype (Sousa-Nunes et al., 2009) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) Rac protein signal transduction inferred from genetic interaction with Rac1 (Zarske and Hafen, 2003)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Sousa-Nunes et al., 2009) nucleus inferred from direct assay (Sousa-Nunes et al., 2009)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions flfl allele Gene References unspecified pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66755 DroID - A comprehensive database of gene and protein interactions. • FBgn0024555 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41675
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16873 Dere\GG19779 Dgri\GH14264 Dmoj\GI23156 Dper\GL23081 Dpse\GA21721 Dsec\GM24121 Dsim\GD18920 Dvir\GJ14468 Dwil\GK14191 Dyak\GE26288
Curated drosophilid orthologs	Dpse\GA21721
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013334-PA Aedes aegypti (mosquito) AGAP003402-PA Anopheles gambiae (mosquito) XP_393542.2 Apis mellifera (honey bee) XP_001944733.1 Acyrthosiphon pisum (pea aphid) At3g06670.1 Arabidopsis thaliana (wall cress) 34430 Batrachochytrium dendrobatidis (chytrid fungus) 89909 Branchiostoma floridae (lancelet) BGIBMGA005022-PA Bombyx mori (silk worm) ENSBTAP00000000709 Bos taurus (bovine) CAL0000468 Candida albicans (a form of yeast) CN29801 Caenorhabditis brenneri (small nematode) CBP37402 Caenorhabditis briggsae (nematode) CE41239 Caenorhabditis elegans (worm) ENSCAFP00000025926 Canis familiaris (dog) CAGL0I01056g Candida glabrata (haploid yeast) ENSCINP00000010039 Ciona intestinalis (sea squirt) JA02838 Caenorhabditis japonica (nematode) cn09279 Cryptococcus neoformans (yeast-like fungus) cgd3_2400 Cryptosporidium parvum (protozoan parasite) CPIJ006330 Culex pipens (mosquito) ENSCPOP00000009886 Cavia porcellus (guinea pig) 170459 Chlamidomonas reinhardtii (green alga) RP35812 Caenorhabditis remanei (nematode) ENSCSAVP00000003274 Ciona savignyi (sedentary tunicate) 182297 Capitella spl (polychaete worm) DDB0232046 Dictyostelium discoideum (amoeba) DEHA2C02156g Debaryomyces Hansenii (yeast) 62030 Daphnia pulex (daphnia) ENSDARP00000061842 Danio rerio (zebra fish) ENSECAP00000011994 Equus caballus (horse) XP_648601 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000014338 Gymnopilus aculeatus (mushroom) ENSGALP00000017444 Gallus gallus (chicken) 111611 Hypsipyla robusta (cedar shoot borer) ENSP00000337125 Homo sapiens (human) ISCW015144-PA Ixodes scapularis (deer tick) KLLA0D18887g Kluyveromyces lactis (yeast) 169795 Lottia gigantea (owl limpet) 8951 Monocosta brevicollis (choanoflagellate) ENSMODP00000003078 Monodelphis domestica (gray opossum) ENSMMUP00000009187 Macaca mulatta (rhesus monkey) ENSMUSP00000041667 Mus musculus (house mouse) 245349 Nematostella vectensis (starlet anemone) XP_001600817.1 Nasonia vitripennis (wasp) ENSOANP00000006049 Ornithorynchus anatinus (platypus) ENSORLP00000005488 Oryzias latipes (japanese killifish) LOC_Os01g23590.1 Oryza sativa (asian rice) 21492 Ostreococcus tauri (green alga) PHUM000491-PA Pediculus humanus (human body louse) PP25189 Pristionchus pacificus (nematode) 138057 Physcomitrella patens (moss) ENSPPYP00000013836 Pongo pygmaeus (orangutan) 143606 Phytophthora sojae (root rot pathogen) 803495 Populus trichocarpa (black cottonwood) ENSPTRP00000011311 Pan troglodytes (chimpanzee) ENSRNOP00000005170 Rattus norvegicus (norway rat) 4878612 Sorghum bicolor (sorghum) YNL201C Saccharomyces cerevisiae (budding yeast) Smp_072350 Schistosoma mansoni (trematode parasite) SPBC216.01c Schizosaccharomyces pombe (fission yeast) 50359 Trichoplax adhaerens (metazoa) XP_974259.2 Tribolium castaneum (red flour beetle) Tc00.1047053510599.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000015261 Tetraodon nigroviridis (green spotted pufferfish) TP03_0573 Theileria parva (parasitic protozoan) 269314 Thalassiosira pseudonana (marine diatom) ENSTRUP00000014867 Takifugu rubripes (pufferfish Takifugu) 16.m00442 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000034483 Xenopus tropicalis (frog) YALI0A17809g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17279 NV16100 LH22367 ISCW015144 FBgn0243319 FBgn0216197 FBgn0201679 FBgn0190431 FBgn0178985 JGI_V11_62030 FBgn0081706 FBgn0160671 FBgn0145883 FBgn0121740 FBgn0111980 FBgn0093893 CPIJ006330 BGIBMGA005022 ACYPI000271 GB14118 AGAP003402 AAEL013334 PHUM546570 GLEAN_09066
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	31690 y1 v1; P{TRiP.JF01896}attP2 31961 y1 v1; P{TRiP.JF02802}attP2/TM3, Sb1 20513 y1 w67c23; P{wHy}flflDG29504 omdDG29504 15657 y1 w67c23; P{EPgy2}flflEY03585 omdEY03585 19907 y1 w67c23; P{EPgy2}omdEY03622 flflEY03622 33374 y1 sc* v1; P{TRiP.HMS00247}attP2/TM3, Sb1 10252 y1 w1118; P{lacW}flflL4179 omdL4179/TM3, Ser1
Harvard	- P{XP}flfld07513
Kyoto	201475 y1 w67c23; P{GSV6}flflGS9037/TM3, Sb1 Ser1
VDRC	v103793 P{KK102767}VIE-260B v24143 w1118; P{GD14196}v24143
Genomic Clones ( 2 )
	BACR03J04 BACR30G22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 138 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD13350 LD26904
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT19320 AT19954 GH24045 LD17854 LD17935 LD18014 LP23867 RE19964 SD14766
Other clones	4834 11124 12190 16097 20929 30000.2 33943 34999 54275 61456 61686 62808 63051 66227 66293 74732 78354 97359 101526 145742 190704 191667 273326 277024 281047 281238 CK01.7B.E11 CK01.12B.E8 CK01.18A.F12 CK01.54B.H8 CK01.55B.C2 CK01.69B.D3 CK01.79D.A2 CK01.92B.E8 CK01.102B.G2 CK01.109C.F3 CK01.111C.E4 CK01.114D.D2 CK01.125A.B2 CK01104 EK010320 EK042207 EK044164 EK044941 EK061933 EK072152 EK073908 EK078557 EK086157 EK098922 EK110816 EK112936 EK123743 EK127849 EK134619 EK184858 EK184963 EK188349 EK188940 EK194062 EK194254 EK228032 EK247607 EK261439 EK281309 EK293021 EK295020 EK303828 EK305958 EK306111 FGM313F07 IP11014 LD24283 RP004032636 RP004074989 RP004103918 RP004115805 RP004143751 RP004151016 RP004152727 RP004158893 RP004163660 RP004164273 RP004168308 RP004177893 RP004178680 RP004195534 RP004195948 RP004196950 RP004200283 RP004203119 RP004206630 RP004208860 RP004209292 RP004210360 RP004212856 RP004215247 RP004215532 RP004216516 RP004236810 RP004243380 RP004244709 RP004248422 RP004252908 RP004258704 RP004260972 RP004300643 RP004355579 RP004356846 RP004372804 RP004384866 RP004391919 RP004407380 RP004432306 RP004447622 RP004453193 RP004459019 RP004464234 RP004466094 RP004483541 RP004483924 RP004497383 RP004500812 RP004511341 RP004515185 RP004544207 RP004547549
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024555 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41675
Antibody Information
	polyclonal (Sousa-Nunes et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: flfl CG9351 (FlyBase, 1996-)
Additional comments	Source for merge of sec13 BEST:CK00043 was sequence comparison (date:030820). (FlyBase, 1996-)
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142047 NM_169548 RefSeq (Proteins) • NP_650304 NP_731849 DDBJ / EMBL / GenBank • AA438950 AA942589 AAF54974 AAM49877 AAM49905 AAN13587 AQ026264 AW942267 AW942861 AY118508 AY118536 CL632141 CZ475783 Entrez Gene - A searchable database of RefSeq genes. • 41675 UniProtKB/TrEMBL • Q8MSW1 Q9VFS5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Domain of unknown function DUF625 (IPR006887) Pleckstrin homology-type (IPR011993)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66755 DroID - A comprehensive database of gene and protein interactions. • FBgn0024555 DRSC - Results from RNAi screens. • FBgn0024555 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024555 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9351-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024555 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41675 InParanoid A subset of ortholog calls from InParanoid. • AAEL013334-PA Aedes aegypti (mosquito) AGAP003402-PA Anopheles gambiae (mosquito) XP_393542.2 Apis mellifera (honey bee) XP_001944733.1 Acyrthosiphon pisum (pea aphid) At3g06670.1 Arabidopsis thaliana (wall cress) 34430 Batrachochytrium dendrobatidis (chytrid fungus) 89909 Branchiostoma floridae (lancelet) BGIBMGA005022-PA Bombyx mori (silk worm) ENSBTAP00000000709 Bos taurus (bovine) CAL0000468 Candida albicans (a form of yeast) CN29801 Caenorhabditis brenneri (small nematode) CBP37402 Caenorhabditis briggsae (nematode) CE41239 Caenorhabditis elegans (worm) ENSCAFP00000025926 Canis familiaris (dog) CAGL0I01056g Candida glabrata (haploid yeast) ENSCINP00000010039 Ciona intestinalis (sea squirt) JA02838 Caenorhabditis japonica (nematode) cn09279 Cryptococcus neoformans (yeast-like fungus) cgd3_2400 Cryptosporidium parvum (protozoan parasite) CPIJ006330 Culex pipens (mosquito) ENSCPOP00000009886 Cavia porcellus (guinea pig) 170459 Chlamidomonas reinhardtii (green alga) RP35812 Caenorhabditis remanei (nematode) ENSCSAVP00000003274 Ciona savignyi (sedentary tunicate) 182297 Capitella spl (polychaete worm) DDB0232046 Dictyostelium discoideum (amoeba) DEHA2C02156g Debaryomyces Hansenii (yeast) 62030 Daphnia pulex (daphnia) ENSDARP00000061842 Danio rerio (zebra fish) ENSECAP00000011994 Equus caballus (horse) XP_648601 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000014338 Gymnopilus aculeatus (mushroom) ENSGALP00000017444 Gallus gallus (chicken) 111611 Hypsipyla robusta (cedar shoot borer) ENSP00000337125 Homo sapiens (human) ISCW015144-PA Ixodes scapularis (deer tick) KLLA0D18887g Kluyveromyces lactis (yeast) 169795 Lottia gigantea (owl limpet) 8951 Monocosta brevicollis (choanoflagellate) ENSMODP00000003078 Monodelphis domestica (gray opossum) ENSMMUP00000009187 Macaca mulatta (rhesus monkey) ENSMUSP00000041667 Mus musculus (house mouse) 245349 Nematostella vectensis (starlet anemone) XP_001600817.1 Nasonia vitripennis (wasp) ENSOANP00000006049 Ornithorynchus anatinus (platypus) ENSORLP00000005488 Oryzias latipes (japanese killifish) LOC_Os01g23590.1 Oryza sativa (asian rice) 21492 Ostreococcus tauri (green alga) PHUM000491-PA Pediculus humanus (human body louse) PP25189 Pristionchus pacificus (nematode) 138057 Physcomitrella patens (moss) ENSPPYP00000013836 Pongo pygmaeus (orangutan) 143606 Phytophthora sojae (root rot pathogen) 803495 Populus trichocarpa (black cottonwood) ENSPTRP00000011311 Pan troglodytes (chimpanzee) ENSRNOP00000005170 Rattus norvegicus (norway rat) 4878612 Sorghum bicolor (sorghum) YNL201C Saccharomyces cerevisiae (budding yeast) Smp_072350 Schistosoma mansoni (trematode parasite) SPBC216.01c Schizosaccharomyces pombe (fission yeast) 50359 Trichoplax adhaerens (metazoa) XP_974259.2 Tribolium castaneum (red flour beetle) Tc00.1047053510599.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000015261 Tetraodon nigroviridis (green spotted pufferfish) TP03_0573 Theileria parva (parasitic protozoan) 269314 Thalassiosira pseudonana (marine diatom) ENSTRUP00000014867 Takifugu rubripes (pufferfish Takifugu) 16.m00442 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000034483 Xenopus tropicalis (frog) YALI0A17809g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41675 modMine - Data generated by the modENCODE project. • FBgn0024555 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17279 NV16100 LH22367 ISCW015144 FBgn0243319 FBgn0216197 FBgn0201679 FBgn0190431 FBgn0178985 JGI_V11_62030 FBgn0081706 FBgn0160671 FBgn0145883 FBgn0121740 FBgn0111980 FBgn0093893 CPIJ006330 BGIBMGA005022 ACYPI000271 GB14118 AGAP003402 AAEL013334 PHUM546570 GLEAN_09066
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG9351 (Mount, 2001.8.14, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Ni et al., 2010.12.1) flfl (Sage et al., 2007, Stroschein-Stevenson et al., 2006, Buszczak et al., 2007, Sousa-Nunes et al., 2009, Zhou et al., 2008, Dworkin et al., 2009, Chang et al., 2010, Tuxworth et al., 2011) l(3)L4179 (Spradling et al., 1999, ) PP4R3 (Sousa-Nunes et al., 2009)
Name Synonym	falafel (Zarske and Hafen, 2003, Sage et al., 2007, Gregory et al., 2007, Libert, 2007, Sage et al., 2008, Sousa-Nunes et al., 2008, Tuxworth et al., 2011)
Secondary FlyBase IDs
	FBgn0038169
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 2 ) Review  ( 2 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) Conference report  ( 1 ) Computer file  ( 4 )
Recent research papers ( 2 )
	Tuxworth et al., 2011, Hum. Mol. Genet. 20(10): 2037--2047 The Batten disease gene CLN3 is required for the response to oxidative stress. [FBrf0213533] Chang et al., 2010, Dev. Cell 19(5): 778--785 Interplay between the Transcription Factor Zif and aPKC Regulates Neuroblast Polarity and Self-Renewal. [FBrf0212286] Show all research papers ...
Recent reviews ( 1 )
	Sousa-Nunes and Somers, 2010, Commun. Integr. Biol. 3(1): 46--49 Phosphorylation and dephosphorylation events allow for rapid segregation of fate determinants during Drosophila neuroblast asymmetric divisions. [FBrf0211041] Show all reviews ...