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Gene Dmel\fws

General Information
Symbol	Dmel\fws	Species	D. melanogaster
Name	four way stop	Annotation symbol	CG6549
Feature type	protein_coding_gene	FlyBase ID	FBgn0024689
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	dCOG5, COG5
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	36C10-36C10	Sequence location	2L:17,478,442..17,481,029 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene four way stop is referred to in FlyBase by the symbol Dmel\fws (CG6549, FBgn0024689). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: male meiosis cytokinesis; actomyosin contractile ring contraction; meiotic spindle stabilization; cytokinesis after meiosis II; spermatid nucleus elongation; cytokinesis after meiosis I. 11 alleles are reported. The phenotypes of these alleles are annotated with: acroblast; Nebenkern; Nebenkern derivative; spermatid; spermatid axoneme. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Conserved oligomeric Golgi complex subunit 5. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval salivary gland, adult female reproductive system, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1626224_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of fws. Gene sequence location is 2L:17478442..17481029.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms Golgi apparatus
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36C10-36C10   Limits computationally determined from genome sequence between P{lacW}Aac11k06710 and P{EP}CG10413EP2164
Experimentally Determined Cytological Location
Cytogenetic map Notes References 36C-36C   Location based on deficiency mapping.   (Giansanti et al., 2004)
Experimentally Determined Recombination Data
Location	2- (Brill et al., 1998.3.16, Giansanti et al., 2004)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\fws for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) fws-RA FBtr0081000  NM_078866   2477   751 fws-RC FBtr0080999  NM_165221   2428   751 fws-RD FBtr0305685  NM_001259130   2424   751
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein fws-PA   FBpp0080553   85.0   751   6.69     NP_523590   AAF53619 fws-PC   FBpp0080552   85.0   751   6.69     NP_724058   AAN10990 fws-PD   FBpp0296965   85.0   751   6.69     NP_001246059   AFH03733
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Conserved oligomeric Golgi complex subunit 5 (IPR019465)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201632   AA202612   AA392458   AA392752   AA439118   AA439447   AA440355   AA801913   AA816495   AA816698   AA816733   AA820719   AA820907   AA941223   AA942299   AA948834   AA949373   AA949392   AA950867   AA951421   AA951646   AA978537   AA978617   AA978886   AE014134 AAF53619   AE014134 AAN10990   AF171823   AF171831   AE014134 AFH03733   AI061792   AI135859   AI295468   AI297923   AI404782   AI405286   AI455547   AI512161   AI513610   AI515972   AI531211   AI534421   AI541610   AI543422   AW941572   AY069335 AAL39480   BF500811   BF500933   BF501542   BG636776   BH740795   BI170828   BI215042   BI216249   BI231863   BI578678   BI580774   BI635265   BT003257 AAO25014   CO276295   CO276377   CO284680   CO306020   EC082947   EC203522   EC240439   EV600498   GH749249   GH750047   GH750394   GH750780   GH755726   GH756624   GH756862   GH757323   GH758119   GH758391   GH758846   GH758876   GH758896   GH759061   GH759918   GH760096   GH771508   GH772637   GH772662   GH774078   GH776568   GH777135   GH780679   GH782083   GH783238   GH783818   GH784493   GH784563   GH787280   GH787291   GH787932   GH788743   GH790213   GH791064   GH792246   GH792924   GH793634   GH794942   GH795055   GH795083   GH795747   GH798564   GH799149   GH800286   GH802003   GH803823   GH805340   GH807794   GH808573   GH809246   GH810609   GH813094   GH813654   GH816873   GH818977   GH819372   GH819893   GH820208   GH822449   GH823853   GH824701   GH826368   GH827990   GH828058   GH828904   GH831483   GH831707   GH834546   GH834743   GH836938   GH838452   GH839280   GH839405   GH840241   GH840265   GH840472   GH840529   GH840912   GH841439   GH843045   GH844191   GH844239   GH846797   GH846938   GH847517   GH847975   GH848023   GH851508   GH855208   GH855903   GH859962   GH865767   GH866913   GH868168   GH868884   GH870401   GH871323   GH871400   GH874805   GH875079   GH875172   GH875196   GH876233   GH877830   GH880512   GH884232   GH887223   GH889358   GH889720   GH891048   GH892698   GH894278   GH894464   GH894793   GH895417   GH895824   GH896202   GH896749   GH897380   GH897953   GH898562   GH899011   GH899932   GH902252   GH902348   GH903540   GH905700   GH906307   GH907504   GH907916   GH908600   GH908653   GH910745   GH912717   GH914893   GH915249   GH915330   GH916306   GH916905   GH917853   GH919107   GH919728   GH920900   GH920950   GH922632   GH923113   GH924038   GH924237   GH926325   GH927186   GH927934   GH929858   GH930070   GH930102   GH930868   GH932962   GH933742   GH934244   GH935328   GH936924   GH937055   GH938573   GH938682   GH940802
UniProtKB/Swiss-Prot	Q9VJD3
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval salivary gland   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Golgi apparatus inferred from direct assay (assigned by UniProtKB) (Farkas et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval salivary gland, adult female reproductive system, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    111.925 Larval Midgut    92 Larval Hindgut    109.5 Larval Malpighian Tubules    122.7 Larval Fat Body    109.7 Larval Salivary Gland    436.4 Larval Trachea    97.875 Larval Carcass    87.525 Adult Head    90.7 Adult Eye    90.95 Adult Brain    119.8 Adult Thoracic-Abdominal Ganglion    137.1 Adult Crop    134.9 Adult Midgut    103.7 Adult Hindgut    108.6 Adult Malpighian Tubules    102.9 Adult Fat Body    97.1 Adult Salivary Gland    546.2 Adult Heart    67.175 Adult VirginFemale Spermatheca    88.6 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    198.1 Adult Testis    58.2 Adult Male Accessory Gland    398.9 Adult Carcass    83.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    111.925 Larval Midgut    92 Larval Hindgut    109.5 Larval Malpighian Tubules    122.7 Larval Fat Body    109.7 Larval Salivary Gland    436.4 Larval Trachea    97.875 Larval Carcass    87.525 Adult Head    90.7 Adult Eye    90.95 Adult Brain    119.8 Adult Thoracic-Abdominal Ganglion    137.1 Adult Crop    134.9 Adult Midgut    103.7 Adult Hindgut    108.6 Adult Malpighian Tubules    102.9 Adult Fat Body    97.1 Adult Salivary Gland  (546.2) Adult Heart    67.175 Adult VirginFemale Spermatheca    88.6 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    198.1 Adult Testis    58.2 Adult Male Accessory Gland    398.9 Adult Carcass    83.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    111.925 Larval Midgut    92 Larval Hindgut    109.5 Larval Malpighian Tubules    122.7 Larval Fat Body    109.7 Larval Salivary Gland    436.4 Larval Trachea    97.875 Larval Carcass    87.525 Adult Head    90.7 Adult Eye    90.95 Adult Brain    119.8 Adult Thoracic-Abdominal Ganglion    137.1 Adult Crop    134.9 Adult Midgut    103.7 Adult Hindgut    108.6 Adult Malpighian Tubules    102.9 Adult Fat Body    97.1 Adult Salivary Gland    546.2 Adult Heart    67.175 Adult VirginFemale Spermatheca    88.6 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    198.1 Adult Testis    58.2 Adult Male Accessory Gland    398.9 Adult Carcass    83.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    111.925 Larval Midgut    92 Larval Hindgut    109.5 Larval Malpighian Tubules    122.7 Larval Fat Body    109.7 Larval Salivary Gland    436.4 Larval Trachea    97.875 Larval Carcass    87.525 Adult Head    90.7 Adult Eye    90.95 Adult Brain    119.8 Adult Thoracic-Abdominal Ganglion    137.1 Adult Crop    134.9 Adult Midgut    103.7 Adult Hindgut    108.6 Adult Malpighian Tubules    102.9 Adult Fat Body    97.1 Adult Salivary Gland    546.2 Adult Heart    67.175 Adult VirginFemale Spermatheca    88.6 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    198.1 Adult Testis    58.2 Adult Male Accessory Gland    398.9 Adult Carcass    83.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    111.925 Larval Midgut    92 Larval Hindgut    109.5 Larval Malpighian Tubules    122.7 Larval Fat Body    109.7 Larval Salivary Gland    436.4 Larval Trachea    97.875 Larval Carcass    87.525 Adult Head    90.7 Adult Eye    90.95 Adult Brain    119.8 Adult Thoracic-Abdominal Ganglion    137.1 Adult Crop    134.9 Adult Midgut    103.7 Adult Hindgut    108.6 Adult Malpighian Tubules    102.9 Adult Fat Body    97.1 Adult Salivary Gland    546.2 Adult Heart    67.175 Adult VirginFemale Spermatheca    88.6 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    198.1 Adult Testis    58.2 Adult Male Accessory Gland    398.9 Adult Carcass    83.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    111.925 Larval Midgut    92 Larval Hindgut    109.5 Larval Malpighian Tubules    122.7 Larval Fat Body    109.7 Larval Salivary Gland    436.4 Larval Trachea    97.875 Larval Carcass    87.525 Adult Head    90.7 Adult Eye    90.95 Adult Brain    119.8 Adult Thoracic-Abdominal Ganglion    137.1 Adult Crop    134.9 Adult Midgut    103.7 Adult Hindgut    108.6 Adult Malpighian Tubules    102.9 Adult Fat Body    97.1 Adult Salivary Gland  546.2 Adult Heart    67.175 Adult VirginFemale Spermatheca    88.6 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    198.1 Adult Testis    58.2 Adult Male Accessory Gland    398.9 Adult Carcass    83.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    111.925 Larval Midgut    92 Larval Hindgut    109.5 Larval Malpighian Tubules    122.7 Larval Fat Body    109.7 Larval Salivary Gland    436.4 Larval Trachea    97.875 Larval Carcass    87.525 Adult Head    90.7 Adult Eye    90.95 Adult Brain    119.8 Adult Thoracic-Abdominal Ganglion    137.1 Adult Crop    134.9 Adult Midgut    103.7 Adult Hindgut    108.6 Adult Malpighian Tubules    102.9 Adult Fat Body    97.1 Adult Salivary Gland    546.2 Adult Heart    67.175 Adult VirginFemale Spermatheca    88.6 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    198.1 Adult Testis    58.2 Adult Male Accessory Gland    398.9 Adult Carcass    83.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    111.925 Larval Midgut    92 Larval Hindgut    109.5 Larval Malpighian Tubules    122.7 Larval Fat Body    109.7 Larval Salivary Gland    436.4 Larval Trachea    97.875 Larval Carcass    87.525 Adult Head    90.7 Adult Eye    90.95 Adult Brain    119.8 Adult Thoracic-Abdominal Ganglion    137.1 Adult Crop    134.9 Adult Midgut    103.7 Adult Hindgut    108.6 Adult Malpighian Tubules    102.9 Adult Fat Body    97.1 Adult Salivary Gland    546.2 Adult Heart    67.175 Adult VirginFemale Spermatheca    88.6 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    198.1 Adult Testis    58.2 Adult Male Accessory Gland    398.9 Adult Carcass    83.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    90.7   NA  Eye    90.95   NA  Brain    119.8   111.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    137.1   NA  Crop    134.9   92  Midgut    103.7   109.5  Hindgut    108.6   122.7  Malpighian Tubules    102.9   109.7  Fat Body    97.1   436.4  Salivary Gland    546.2   NA  Heart    67.175   97.875  Trachea    NA   NA  VirginFemale Spermatheca    88.6   NA  InseminatedFemale Spermatheca    104.3   NA  Ovary    198.1   NA  Testis    58.2   NA  Male Accessory Gland    398.9   87.525  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    9 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    7 carcass, larvae L3 wandering    11 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    31 ovary, mated 4-day female    22 testis, mated 4-day male    8 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    9 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    7 carcass, larvae L3 wandering    11 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female  (31) ovary, mated 4-day female    22 testis, mated 4-day male    8 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    9 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    7 carcass, larvae L3 wandering    11 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    31 ovary, mated 4-day female    22 testis, mated 4-day male    8 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    9 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    7 carcass, larvae L3 wandering    11 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    31 ovary, mated 4-day female    22 testis, mated 4-day male    8 accessory gland, mated 4-day male    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    9 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    7 carcass, larvae L3 wandering    11 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    31 ovary, mated 4-day female    22 testis, mated 4-day male    8 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    9 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    7 carcass, larvae L3 wandering    11 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female  31 ovary, mated 4-day female    22 testis, mated 4-day male    8 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    9 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    7 carcass, larvae L3 wandering    11 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    31 ovary, mated 4-day female    22 testis, mated 4-day male    8 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    9 head, mated 4-day male    11 head, mated 20-day male    15 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    7 carcass, larvae L3 wandering    11 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    31 ovary, mated 4-day female    22 testis, mated 4-day male    8 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    65 embryo 04-06hr    27 embryo 06-08hr    26 embryo 08-10hr    29 embryo 10-12hr    26 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    10 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    10 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    17 adult female 05day    29 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52) embryo 02-04hr  (65) embryo 04-06hr  (27) embryo 06-08hr  26 embryo 08-10hr  (29) embryo 10-12hr  26 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    10 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    10 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    17 adult female 05day  (29) adult female 30day  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    65 embryo 04-06hr    27 embryo 06-08hr    26 embryo 08-10hr    29 embryo 10-12hr    26 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    10 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    10 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    17 adult female 05day    29 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    65 embryo 04-06hr    27 embryo 06-08hr    26 embryo 08-10hr    29 embryo 10-12hr    26 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    10 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    10 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    17 adult female 05day    29 adult female 30day    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    65 embryo 04-06hr    27 embryo 06-08hr    26 embryo 08-10hr    29 embryo 10-12hr    26 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    10 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    10 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    17 adult female 05day    29 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52) embryo 02-04hr  (65) embryo 04-06hr  27 embryo 06-08hr  26 embryo 08-10hr  29 embryo 10-12hr  26 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    10 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    10 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    17 adult female 05day  29 adult female 30day  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    65 embryo 04-06hr    27 embryo 06-08hr    26 embryo 08-10hr    29 embryo 10-12hr    26 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    10 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    10 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    17 adult female 05day    29 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    65 embryo 04-06hr    27 embryo 06-08hr    26 embryo 08-10hr    29 embryo 10-12hr    26 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    10 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    10 larva L2    14 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    18 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    17 adult female 05day    29 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    24 embryonic 1182-4H    22 embryonic GM2    32 embryonic Kc167    21 embryonic S1    61 embryonic S3    27 leg disc CME L1    28 wing disc CME-W2    25 wing disc ML-DmD8    17 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    14 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    26 ovary fGS/OSS    14 ovary OSC    16 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (33) Schneider line 2 Sg4    24 embryonic 1182-4H    22 embryonic GM2  (32) embryonic Kc167    21 embryonic S1  (61) embryonic S3  (27) leg disc CME L1  (28) wing disc CME-W2    25 wing disc ML-DmD8    17 wing disc ML-DmD9  (30) wing disc ML-DmD16-c3    21 wing disc ML-DmD21    14 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1  (30) CNS ML-DmBG2-c2    25 tumorous blood cells mbn2  26 ovary fGS/OSS    14 ovary OSC    16 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    24 embryonic 1182-4H    22 embryonic GM2    32 embryonic Kc167    21 embryonic S1    61 embryonic S3    27 leg disc CME L1    28 wing disc CME-W2    25 wing disc ML-DmD8    17 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    14 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    26 ovary fGS/OSS    14 ovary OSC    16 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    24 embryonic 1182-4H    22 embryonic GM2    32 embryonic Kc167    21 embryonic S1    61 embryonic S3    27 leg disc CME L1    28 wing disc CME-W2    25 wing disc ML-DmD8    17 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    14 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    26 ovary fGS/OSS    14 ovary OSC    16 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    24 embryonic 1182-4H    22 embryonic GM2    32 embryonic Kc167    21 embryonic S1    61 embryonic S3    27 leg disc CME L1    28 wing disc CME-W2    25 wing disc ML-DmD8    17 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    14 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    26 ovary fGS/OSS    14 ovary OSC    16 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (33) Schneider line 2 Sg4    24 embryonic 1182-4H    22 embryonic GM2  32 embryonic Kc167    21 embryonic S1  (61) embryonic S3  27 leg disc CME L1  28 wing disc CME-W2    25 wing disc ML-DmD8    17 wing disc ML-DmD9  30 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    14 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1  30 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2  26 ovary fGS/OSS    14 ovary OSC    16 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    24 embryonic 1182-4H    22 embryonic GM2    32 embryonic Kc167    21 embryonic S1    61 embryonic S3    27 leg disc CME L1    28 wing disc CME-W2    25 wing disc ML-DmD8    17 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    14 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    26 ovary fGS/OSS    14 ovary OSC    16 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    24 embryonic 1182-4H    22 embryonic GM2    32 embryonic Kc167    21 embryonic S1    61 embryonic S3    27 leg disc CME L1    28 wing disc CME-W2    25 wing disc ML-DmD8    17 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    14 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    26 ovary fGS/OSS    14 ovary OSC    16 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD24842 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024689 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6549-RC FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for fws Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 fwsGD11957 Sterility Allele male sterile | recessive fwsz-0161 fwsz-1201 Other Phenotypes Allele cytokinesis defective (with Df(2L)qua1374) fwsz-0161 cytokinesis defective | male (with Df(2L)qua1374) fwsZ0161 cytokinesis defective | male | recessive fwsZ0161 fwsZ1201 meiotic cell cycle defective | male (with Df(2L)qua1374) fwsZ0161 meiotic cell cycle defective | male | recessive fwsZ0161 fwsZ1201 mitotic cell cycle defective | male (with Df(2L)qua1374) fwsZ0161 mitotic cell cycle defective | male | recessive fwsZ0161 fwsZ1201 Phenotype manifest in Allele acroblast (with Df(2L)qua1374) fwsz-0161 contractile ring & meiotic telophase I | male fwsZ0161 contractile ring & meiotic telophase I | male (with Df(2L)qua1374) fwsZ0161 contractile ring & meiotic telophase II | male fwsZ0161 contractile ring & meiotic telophase II | male (with Df(2L)qua1374) fwsZ0161 germline cyst | male fwsz-0161 Nebenkern fwsZ0161 fwsZ1201 Nebenkern (with Df(2L)qua1374) fwsZ0161 Nebenkern derivative fwsz-0161 spermatid fwsz-0161 spermatid & nucleus | supernumerary fwsZ0161 fwsZ1201 fwsz-0161 spermatid & nucleus | supernumerary (with Df(2L)qua1374) fwsZ0161 spermatid axoneme (with Df(2L)qua1374) fwsz-0161 spermatocyte & contractile ring fwsz-0161 spermatocyte & contractile ring (with Df(2L)qua1374) fwsz-0161 spermatocyte & spindle fwsz-0161 spermatocyte & spindle (with Df(2L)qua1374) fwsz-0161 spindle & meiotic telophase I | male fwsZ0161 spindle & meiotic telophase I | male (with Df(2L)qua1374) fwsZ0161 spindle & meiotic telophase II | male fwsZ0161 spindle & meiotic telophase II | male (with Df(2L)qua1374) fwsZ0161
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of fws Class Mutagen Stocks Known lesion fwsKG02853 P-element activity 1 -- fwsunspecified 0 -- fwsz-0161 ethyl methanesulfonate 0 Yes fwsz-1201 ethyl methanesulfonate 0 Yes fwsZ0161 ethyl methanesulfonate 0 -- fwsZ1201 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of fws Class Mutagen Stocks Known lesion fwsGD11957 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fws+t7 in vitro construct - genomic fragment 0 Yes fwsKK101056 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes fwsNIG.6549R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes fwsT:Avic\GFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7068 (Ryder, 2004.4.26) Df(2L)qua1374 (Giansanti et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11957} NA P{KK101056} NA P{NIG.6549R} NA characterization construct P{fws::GFP} NA P{fws+t7} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}fwsKG02853 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actomyosin contractile ring contraction inferred from mutant phenotype (Giansanti et al., 2004) cytokinesis after meiosis I inferred from mutant phenotype (Giansanti et al., 2004) cytokinesis after meiosis II inferred from mutant phenotype (Giansanti et al., 2004) male meiosis cytokinesis inferred from mutant phenotype (assigned by UniProtKB) (Farkas et al., 2003) meiotic spindle stabilization inferred from mutant phenotype (Giansanti et al., 2004) spermatid nucleus elongation inferred from mutant phenotype (assigned by UniProtKB) (Farkas et al., 2003)
Cellular Component
CV term Evidence References
Golgi apparatus inferred from direct assay (assigned by UniProtKB) (Farkas et al., 2003)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cellular membrane organization non-traceable author statement (Gonzalez and Bornens, 2000) intra-Golgi vesicle-mediated transport inferred from electronic annotation with InterPro:IPR019465 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
Golgi transport complex inferred from sequence or structural similarity with EMBL:AF058718 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions fws allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61050 DroID - A comprehensive database of gene and protein interactions. • FBgn0024689 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35054
Orthologs
OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XKVSD Dipteran inclusive ortholog search EOG69CQGR Insect inclusive ortholog search EOG641P6F Arthropod inclusive ortholog search EOG6STQKM Metazoa inclusive ortholog search EOG64FK30
Orthologs in Drosophila Species (EOG6XKVSD)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\fws     Drosophila simulans   Dsim\GD21865 Y   Drosophila sechellia   Dsec\GM17124 Y   Drosophila erecta   Dere\GG21741 Y   Drosophila yakuba   Dyak\GE13130 Y   Drosophila ananassae   Dana\GF15100 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19678 Y   Drosophila persimilis   Dper\GL15955 Y   Drosophila willistoni   Dwil\GK24828 Y   Drosophila virilis   Dvir\GJ20316 Y   Drosophila mojavensis   Dmoj\GI22420 Y   Drosophila grimshawi   Dgri\GH10156 Y
Orthologs in non-Drosophila Dipterans (EOG69CQGR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005180   Anopheles gambiae Malaria mosquito  Agam\AGAP005853   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014696
Orthologs in non-Dipteran Insects (EOG641P6F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45343   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15954   Atta cephalotes Leafcutter ant  Acep\ACEP14645   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19599   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18366   Linepithema humile Argentine ant  Lhum\LH12222   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14330   Solenopsis invicta Red fire ant  Sinv\SINV18204   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005725   Bombyx mori Silkmoth  Bmor\BGIBMGA007170   Pediculus humanus Human body louse  Phum\PHUM418010   Tribolium castaneum Red flour beetle  Tcas\TC013924
Orthologs in non-Insect Arthropods (EOG6STQKM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_334740   Daphnia pulex Water flea  Dpux\JGI_V11_57970   Daphnia pulex Water flea  Dpux\JGI_V11_274663   Daphnia pulex Water flea  Dpux\JGI_V11_316118   Ixodes scapularis Deer tick  Isca\ISCW017365
Orthologs in non-Arthropod Metazoa (EOG64FK30)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cogc-5   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024732gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013042gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008691gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026186gn   Danio rerio Zebrafish  Drer\si:dkey-217k21.3   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033924   Gallus gallus Domestic chicken  Ggal\COG5   Mus musculus House mouse  Mmus\Cog5   Rattus norvegicus Norway rat  Rnor\RGD1563296   Homo sapiens Human  Hsap\COG5
Human Orthologs (1)
Gene OMIM HGNC Hsap\COG5
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21865 Drosophila sechellia Dsec\GM17124 Drosophila erecta Dere\GG21741 Drosophila yakuba Dyak\GE13130 Drosophila ananassae Dana\GF15100 Drosophila pseudoobscura pseudoobscura Dpse\GA19678 Drosophila persimilis Dper\GL15955 Drosophila willistoni Dwil\GK24828 Drosophila virilis Dvir\GJ20316 Drosophila mojavensis Dmoj\GI22420 Drosophila grimshawi Dgri\GH10156
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	13496 y1; P{SUPor-P}fwsKG02853
VDRC	v27661 w1118 P{GD11957}v27661
Genomic Clones ( 1 )
	BACR07M13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 222 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD05118 LD24842
Other clones	AF171823 AF171831
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT15855 AT16088 AT16908 GH13759 GH24614 GH25241 GM03575 LD01925 LD02749 LD04193 LD04693 LD11331 LD11888 LD13589 LD14023 LD14931 LD24576 LD25244 LD26419 LD27494 LD28244 LD28271 LD30785 LD31020 LD31874 LD32102 LD32285 LD33070 LD34910 LD41694 LD43906 LD45806 LP09117 LP12370 RE12426 RE21233 RE23210 RE24809 RE72575 RE75008 SD02154 SD05610 SD07233 SD10164 SD16563
Other clones	147470 CK01.18A.E7 CK01.147B.E12 Dmel_neb_014021_0848_1385 EK120306 EK120652 EK166539 EK250118 RP003012902 RP003021885 RP003049328 RP003050800 RP003056620 RP003062537 RP003065036 RP003066171 RP003068924 RP003069073 RP003073059 RP003077061 RP003080493 RP003082754 RP003082901 RP003093923 RP003103787 RP003106813 RP003109723 RP003115017 RP003117665 RP003127110 RP003131921 RP003133394 RP003137261 RP003139967 RP003140885 RP003144043 RP003177093 RP003177299 RP003183989 RP003192267 RP003196033 RP003204827 RP003208259 RP003209627 RP003219286 RP003221112 RP003223650 RP003224502 RP003227432 RP003230152 RP003232806 RP003233835 RP003235381 RP003243642 RP003251660 RP003253282 RP003255006 RP003258295 RP003259579 RP003264546 RP003273076 RP003273174 RP003279183 RP003279202 RP003280122 RP003281471 RP003285843 RP003286683 RP003293208 RP003294004 RP003299869 RP003300282 RP003303464 RP003305960 RP003306167 RP003306894 RP003314133 RP003314831 RP003318386 RP003321210 RP003322977 RP003323892 RP003324377 RP003329126 RP003330027 RP003331915 RP003331955 RP003334627 RP003334855 RP003334971 RP003342113 RP003345217 RP003345240 RP003349691 RP003352312 RP003353296 RP003359618 RP003379633 RP003385651 RP003387207 RP003387582 RP003390784 RP003404803 RP003414714 RP003420274 RP003441028 RP003443300 RP003443409 RP003443711 RP003446026 RP003449385 RP003452719 RP003457411 RP003461575 RP003466750 RP003471907 RP003474939 RP003480571 RP003497553 RP003500433 RP003505645 RP003511828 RP003514022 RP003514949 RP003517004 RP003519016 RP003519045 RP003521914 RP003524437 RP003529681 RP003532027 RP003536235 RP003538297 RP003541176 RP003543188 RP003549028 RP003549401 RP003552997 RP003554837 RP003555083 RP003557336 RP003557975 RP003564188 RP003565478 RP003574406 RP003574947 RP003579057 RP003580934 RP003584988 RP003590433 RP003595160 RP003603329 RP003603442 RP003606876 RP003611552 RP003617721 RP003625855 RP003627979 RP003629542 RP003634229 RP003635365 RP003638575 RP003639501 RP003639621 RP003642415 RP003643896 RP003646844 RP003647857 RP003650786 RP003655190 RP003664754 RP003676508 SD14559
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024689 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35054
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG6549 anon-EST:Posey162 (Bayraktaroglu, 2000.11.2) Source for merge of: fws anon-EST:Posey186 (Ashburner, 2004.6.30) Source for merge of: fws CG6549 (Farkas, 2001.3.12)
Additional comments
Other Comments
	Mutants are viable and male sterile. (Farkas, 2001.3.12) The phenotype of mutants is a failure in meiotic cytokinesis ("four wheel drive" phenotype), as well as a failure in proper polarization and bundling of the cysts of elongating spermatids. The end result is an accumulation of ovoid cysts containing multinucleate spermatids. The flies are male sterile. (Brill et al., 1998.3.16)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078866 NM_165221 NM_001259130 RefSeq (Proteins) • NP_523590 NP_724058 NP_001246059 DDBJ / EMBL / GenBank • AA816733 AA820907 AAF53619 AAL39480 AAN10990 AAO25014 AF171823 AF171831 AFH03733 AI455547 AW941572 AY069335 BH740795 BT003257 Entrez Gene - A searchable database of RefSeq genes. • 35054 UniProtKB/Swiss-Prot • Q9VJD3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Conserved oligomeric Golgi complex subunit 5 (IPR019465) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD24842
Linkouts
	BioGRID - A database of protein and genetic interactions • 61050 DroID - A comprehensive database of gene and protein interactions. • FBgn0024689 DRSC - Results from RNAi screens. • FBgn0024689 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024689 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6549-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024689 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35054 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35054 modMine - Data generated by the modENCODE project. • FBgn0024689
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	anon-EST:Posey162   anon-EST:Posey186   CG6549 (Ashburner, 2004.6.30, Farkas et al., 2003, Keleman et al., 2009.8.5) COG5 (Ungar et al., 2006) Cog5 (Giansanti et al., 2006) dCOG5 (Herpers and Rabouille, 2004, Lee and Cooley, 2007, Nicolas et al., 2009) fws (Farkas et al., 2003, Lee and Cooley, 2007, Koch et al., 2009, Giansanti et al., 2006, Morris et al., 2006, Japanese National Institute of Genetics, 2012.5.21) FWS (Fan et al., 2011) Fws (Polevoy et al., 2009, Robinett et al., 2009, Zhou et al., 2011)
Name Synonym	Drosophila Cog5 (Farkas et al., 2003) four way stop (Brill et al., 1998.3.16, Farkas et al., 2003, Giansanti et al., 2006) Four-way stop (Robinett et al., 2009) Four Way Stop (Zhou et al., 2011)
Secondary FlyBase IDs
	FBgn0027736 FBgn0027744 FBgn0032641
References ( 38 )
Generate a list of	All references relating to this gene ( 38 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Conference report  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Fan et al., 2011, PLoS ONE 6(5): e20612 Drosophila Ge-1 Promotes P Body Formation and oskar mRNA Localization. [FBrf0213914] Zhou et al., 2011, Development 138(6): 1111--1120 Auxilin is required for formation of Golgi-derived clathrin-coated vesicles during Drosophila spermatogenesis. [FBrf0213068] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...