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Gene Dmel\PRL-1

General Information
Symbol	Dmel\PRL-1	Species	D. melanogaster
Name	PRL-1	Annotation symbol	CG4993
Feature type	protein_coding_gene	FlyBase ID	FBgn0024734
Gene Model Status	Current	Stock availability	17 publicly available
Also Known As	BG:DS07473.3
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35F1-35F1	Sequence location	2L:16,245,835..16,257,606 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene PRL-1 is referred to in FlyBase by the symbol Dmel\PRL-1 (CG4993, FBgn0024734). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: prenylated protein tyrosine phosphatase activity. It is reported to be involved in the biological process: protein dephosphorylation. 27 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Dual specificity phosphatase, catalytic domain; Protein-tyrosine/Dual specificity phosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 12-24 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, larval fat body, adult female reproductive system, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1631728_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of PRL-1. Gene sequence location is 2L:16245835..16257606.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35F1-35F1   Limits computationally determined from genome sequence between P{lacW}CycEk05007&P{lacW}CycEk02602 and P{EP}crpEP721&P{lacW}crpk07829
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35F1-35F2   (determined by in situ hybridisation) 35F1--5 (determined by in situ hybridisation)   (Ashburner et al., 1999) 35F1-35F5   (determined by in situ hybridisation)   (Spradling et al., 1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\PRL-1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) PRL-1-RA FBtr0080857  NM_165150   2770   176 PRL-1-RB FBtr0080856  NM_135936   3136   176 PRL-1-RC FBtr0332357  NM_001273558   3153   176 PRL-1-RD FBtr0332358  NM_001273559   2096   176
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein PRL-1-PA   FBpp0080414   20.0   176   8.88     NP_723956   AAF53506 PRL-1-PB   FBpp0080413   20.0   176   8.88     NP_609780   AAN10934 PRL-1-PC   FBpp0304634   20.0   176   8.88     NP_001260487   AGB93022 PRL-1-PD   FBpp0304635   20.0   176   8.88     NP_001260488   AGB93023
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein-tyrosine/Dual specificity phosphatase (IPR000387) Dual specificity phosphatase, catalytic domain (IPR000340)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140816   AA392622   AA538688   AA540959   AA696442   AA803899   AA821150   AA821153   AA979376   AA979397   AA979413   AA990900   AE014134 AAF53506   AE014134 AAN10934   AE003415 AAF44989   AF063902 AAC16552   AF390535 AAL26988   AE014134 AGB93022   AE014134 AGB93023   AI063355   AI108683   AI134675   AI134686   AI456180   AI512996   AI543830   AQ025903   AQ025971   AQ073277   AQ074056   AY071505 AAL49127   AY094872 AAM11225   BG638961   BI164998   BI165462   BI165543   BI166393   BI168137   BI216448   BI216723   BI230448   BI230790   BI231347   BI231358   BI231772   BI234292   BI234435   BI235910   BI237318   BI237640   BI237700   BI240497   BI240655   BI242421   BI242832   BI243396   BI358209   BI364188   BI364605   BI365036   BI365042   BI365049   BI365773   BI366351   BI366353   BI367227   BI369716   BI371208   BI375561   BI481598   BI481874   BI482714   BI483202   BI484131   BI578386   BI579757   BI616282   BI637428   BP540255   BP542340   BP545325   BP545326   BP549656   BP549657   BP552918   BP552919   BP553391   BP553392   BP557562   BP557563   CK657928   CL868533   CL943678   CO152661   CO152727   CO178452   CO179459   CO179566   CO181379   CO186269   CO186271   CO186403   CO186718   CO186790   CO186995   CO189955   CO190475   CO196186   CO263504   CO263554   CO263933   CO263949   CO263977   CO264017   CO265018   CO265790   CO265891   CO267008   CO267569   CO268477   CO269170   CO270400   CO270505   CO273786   CO273955   CO274387   CO275926   CO276981   CO279773   CO280109   CO280967   CO281927   CO282581   CO282631   CO283129   CO283257   CO284670   CO284747   CO284766   CO287990   CO288552   CO289563   CO290206   CO290429   CO290970   CO291084   CO291285   CO292040   CO293577   CO294836   CO295543   CO296648   CO296975   CO298155   CO299196   CO300547   CO301151   CO301419   CO301991   CO302071   CO302678   CO302726   CO303558   CO305064   CO306913   CO307028   CO308129   CO308904   CO309118   CO310543   CO310690   CO311197   CO312047   CO313855   CO314193   CO314954   CO318149   CO318649   CO320363   CO322188   CO324434   CO324671   CO326629   CO329668   CO332027   CO332316   CO332626   CO332630   CO333843   CO338682   CO338857   CO339435   CZ468961   CZ469834   CZ473225   CZ475914   CZ475915   CZ476352   CZ476353   CZ480735   CZ483748   CZ489273   CZ489274   DN154092   EC051381   EC051447   EC054430   EC054440   EC056047   EC057030   EC057541   EC061304   EC061995   EC062328   EC062341   EC062708   EC062771   EC063785   EC065609   EC066616   EC069286   EC069783   EC070366   EC072310   EC072869   EC073556   EC073912   EC074352   EC075367   EC075529   EC075568   EC076158   EC077485   EC078314   EC078343   EC079413   EC080401   EC080859   EC082321   EC083480   EC083743   EC084375   EC085029   EC085094   EC086941   EC087306   EC087889   EC088181   EC088899   EC089160   EC089214   EC091007   EC194588   EC194590   EC196012   EC197070   EC197221   EC199187   EC199290   EC200039   EC200559   EC201331   EC201395   EC201741   EC203261   EC203279   EC204696   EC205261   EC206344   EC206616   EC207420   EC207949   EC207950   EC208547   EC208896   EC209713   EC210948   EC211819   EC212142   EC214161   EC215362   EC216635   EC218936   EC218946   EC219788   EC220873   EC221540   EC222593   EC222640   EC223172   EC224040   EC224330   EC224438   EC225798   EC226097   EC228153   EC228515   EC230776   EC232593   EC232813   EC234754   EC235781   EC235787   EC239348   EC239512   EC239574   EC239671   EC240107   EC240802   EC241446   EC242343   EC242834   EC243603   EC246071   EC248028   EC248712   EC249095   EC249629   EC250061   EC250911   EC251736   EC255500   EC257972   EC260785   EC261717   EC267550   EC268055   EV584924   EV593473   GH748584   GH750507   GH750967   GH760433   GH772359   GH773315   GH773603   GH777184   GH781159   GH781680   GH782494   GH786349   GH801174   GH810575   GH814385   GH817105   GH817133   GH825961   GH829236   GH841527   GH851063   GH855078   GH862750   GH877481   GH877874   GH889204   GH902656   GH903383   GH904751   GH913505   GH914627   GH915930   GH919899   GH921107   GH925031   GH925130   GH940174
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O61722 Q8SX36 Q7KPK2 Q95VY8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, larval fat body, adult female reproductive system, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    976.15 Larval Midgut    1044.5 Larval Hindgut    1302.6 Larval Malpighian Tubules    1023.8 Larval Fat Body    470.3 Larval Salivary Gland    769.1 Larval Trachea    556.025 Larval Carcass    935.475 Adult Head    709 Adult Eye    1089.25 Adult Brain    608.8 Adult Thoracic-Abdominal Ganglion    457.3 Adult Crop    858.6 Adult Midgut    751.4 Adult Hindgut    1024.4 Adult Malpighian Tubules    755.6 Adult Fat Body    536.1 Adult Salivary Gland    715.3 Adult Heart    602.8 Adult VirginFemale Spermatheca    435.9 Adult InseminatedFemale Spermatheca    511.9 Adult Ovary    250.5 Adult Testis    126.1 Adult Male Accessory Gland    901.3 Adult Carcass    595.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (976.15) Larval Midgut  (1044.5) Larval Hindgut  (1302.6) Larval Malpighian Tubules  (1023.8) Larval Fat Body    470.3 Larval Salivary Gland  (769.1) Larval Trachea  (556.025) Larval Carcass  (935.475) Adult Head  (709) Adult Eye  (1089.25) Adult Brain  (608.8) Adult Thoracic-Abdominal Ganglion    457.3 Adult Crop  (858.6) Adult Midgut  (751.4) Adult Hindgut  (1024.4) Adult Malpighian Tubules  (755.6) Adult Fat Body  536.1 Adult Salivary Gland  (715.3) Adult Heart  (602.8) Adult VirginFemale Spermatheca    435.9 Adult InseminatedFemale Spermatheca  511.9 Adult Ovary    250.5 Adult Testis    126.1 Adult Male Accessory Gland  (901.3) Adult Carcass  (595.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    976.15 Larval Midgut  1044.5 Larval Hindgut  (1302.6) Larval Malpighian Tubules  1023.8 Larval Fat Body    470.3 Larval Salivary Gland    769.1 Larval Trachea    556.025 Larval Carcass    935.475 Adult Head    709 Adult Eye  (1089.25) Adult Brain    608.8 Adult Thoracic-Abdominal Ganglion    457.3 Adult Crop    858.6 Adult Midgut    751.4 Adult Hindgut  1024.4 Adult Malpighian Tubules    755.6 Adult Fat Body    536.1 Adult Salivary Gland    715.3 Adult Heart    602.8 Adult VirginFemale Spermatheca    435.9 Adult InseminatedFemale Spermatheca    511.9 Adult Ovary    250.5 Adult Testis    126.1 Adult Male Accessory Gland    901.3 Adult Carcass    595.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    976.15 Larval Midgut    1044.5 Larval Hindgut    1302.6 Larval Malpighian Tubules    1023.8 Larval Fat Body    470.3 Larval Salivary Gland    769.1 Larval Trachea    556.025 Larval Carcass    935.475 Adult Head    709 Adult Eye    1089.25 Adult Brain    608.8 Adult Thoracic-Abdominal Ganglion    457.3 Adult Crop    858.6 Adult Midgut    751.4 Adult Hindgut    1024.4 Adult Malpighian Tubules    755.6 Adult Fat Body    536.1 Adult Salivary Gland    715.3 Adult Heart    602.8 Adult VirginFemale Spermatheca    435.9 Adult InseminatedFemale Spermatheca    511.9 Adult Ovary    250.5 Adult Testis    126.1 Adult Male Accessory Gland    901.3 Adult Carcass    595.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    976.15 Larval Midgut    1044.5 Larval Hindgut    1302.6 Larval Malpighian Tubules    1023.8 Larval Fat Body    470.3 Larval Salivary Gland    769.1 Larval Trachea    556.025 Larval Carcass    935.475 Adult Head    709 Adult Eye    1089.25 Adult Brain    608.8 Adult Thoracic-Abdominal Ganglion    457.3 Adult Crop    858.6 Adult Midgut    751.4 Adult Hindgut    1024.4 Adult Malpighian Tubules    755.6 Adult Fat Body    536.1 Adult Salivary Gland    715.3 Adult Heart    602.8 Adult VirginFemale Spermatheca    435.9 Adult InseminatedFemale Spermatheca    511.9 Adult Ovary    250.5 Adult Testis    126.1 Adult Male Accessory Gland    901.3 Adult Carcass    595.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (976.15) Larval Midgut  (1044.5) Larval Hindgut  (1302.6) Larval Malpighian Tubules  (1023.8) Larval Fat Body    470.3 Larval Salivary Gland  769.1 Larval Trachea  556.025 Larval Carcass  (935.475) Adult Head  709 Adult Eye  (1089.25) Adult Brain  608.8 Adult Thoracic-Abdominal Ganglion    457.3 Adult Crop  (858.6) Adult Midgut  751.4 Adult Hindgut  (1024.4) Adult Malpighian Tubules  755.6 Adult Fat Body  536.1 Adult Salivary Gland  715.3 Adult Heart  602.8 Adult VirginFemale Spermatheca    435.9 Adult InseminatedFemale Spermatheca  511.9 Adult Ovary    250.5 Adult Testis    126.1 Adult Male Accessory Gland  (901.3) Adult Carcass  595.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    976.15 Larval Midgut  1044.5 Larval Hindgut  1302.6 Larval Malpighian Tubules  1023.8 Larval Fat Body    470.3 Larval Salivary Gland    769.1 Larval Trachea    556.025 Larval Carcass    935.475 Adult Head    709 Adult Eye  1089.25 Adult Brain    608.8 Adult Thoracic-Abdominal Ganglion    457.3 Adult Crop    858.6 Adult Midgut    751.4 Adult Hindgut  1024.4 Adult Malpighian Tubules    755.6 Adult Fat Body    536.1 Adult Salivary Gland    715.3 Adult Heart    602.8 Adult VirginFemale Spermatheca    435.9 Adult InseminatedFemale Spermatheca    511.9 Adult Ovary    250.5 Adult Testis    126.1 Adult Male Accessory Gland    901.3 Adult Carcass    595.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    976.15 Larval Midgut    1044.5 Larval Hindgut    1302.6 Larval Malpighian Tubules    1023.8 Larval Fat Body    470.3 Larval Salivary Gland    769.1 Larval Trachea    556.025 Larval Carcass    935.475 Adult Head    709 Adult Eye    1089.25 Adult Brain    608.8 Adult Thoracic-Abdominal Ganglion    457.3 Adult Crop    858.6 Adult Midgut    751.4 Adult Hindgut    1024.4 Adult Malpighian Tubules    755.6 Adult Fat Body    536.1 Adult Salivary Gland    715.3 Adult Heart    602.8 Adult VirginFemale Spermatheca    435.9 Adult InseminatedFemale Spermatheca    511.9 Adult Ovary    250.5 Adult Testis    126.1 Adult Male Accessory Gland    901.3 Adult Carcass    595.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    709   NA  Eye    1089.25   NA  Brain    608.8   976.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    457.3   NA  Crop    858.6   1044.5  Midgut    751.4   1302.6  Hindgut    1024.4   1023.8  Malpighian Tubules    755.6   470.3  Fat Body    536.1   769.1  Salivary Gland    715.3   NA  Heart    602.8   556.025  Trachea    NA   NA  VirginFemale Spermatheca    435.9   NA  InseminatedFemale Spermatheca    511.9   NA  Ovary    250.5   NA  Testis    126.1   NA  Male Accessory Gland    901.3   935.475  Carcass    595.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    77 central nervous system, pupae P8    75 head, virgin 1-day female    44 head, virgin 4-day female    44 head, virgin 20-day female    24 head, mated 1-day female    49 head, mated 4-day female    38 head, mated 20-day female    24 head, mated 1-day male    59 head, mated 4-day male    54 head, mated 20-day male    51 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    46 digestive system, larvae L3 wandering    46 digestive system, 1-day adult    50 digestive system, 4-day adult    47 digestive system, 20-day adult    35 fat body, larvae L3 wandering    17 fat body, white prepupae    42 fat body, pupae P8    38 carcass, larvae L3 wandering    50 carcass, 1-day adult    60 carcass, 4-day adult    45 carcass, 20-day adult    31 ovary, virgin 4-day female    80 ovary, mated 4-day female    64 testis, mated 4-day male    20 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3  (77) central nervous system, pupae P8  (75) head, virgin 1-day female  (44) head, virgin 4-day female  (44) head, virgin 20-day female    24 head, mated 1-day female  (49) head, mated 4-day female  (38) head, mated 20-day female    24 head, mated 1-day male  (59) head, mated 4-day male  (54) head, mated 20-day male  (51) salivary gland, larvae L3 wandering    19 salivary gland, white prepupae  (46) digestive system, larvae L3 wandering  (46) digestive system, 1-day adult  (50) digestive system, 4-day adult  (47) digestive system, 20-day adult  (35) fat body, larvae L3 wandering    17 fat body, white prepupae  (42) fat body, pupae P8  (38) carcass, larvae L3 wandering  (50) carcass, 1-day adult  (60) carcass, 4-day adult  (45) carcass, 20-day adult  (31) ovary, virgin 4-day female  (80) ovary, mated 4-day female  (64) testis, mated 4-day male    20 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    77 central nervous system, pupae P8    75 head, virgin 1-day female    44 head, virgin 4-day female    44 head, virgin 20-day female    24 head, mated 1-day female    49 head, mated 4-day female    38 head, mated 20-day female    24 head, mated 1-day male    59 head, mated 4-day male    54 head, mated 20-day male    51 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    46 digestive system, larvae L3 wandering    46 digestive system, 1-day adult    50 digestive system, 4-day adult    47 digestive system, 20-day adult    35 fat body, larvae L3 wandering    17 fat body, white prepupae    42 fat body, pupae P8    38 carcass, larvae L3 wandering    50 carcass, 1-day adult    60 carcass, 4-day adult    45 carcass, 20-day adult    31 ovary, virgin 4-day female    80 ovary, mated 4-day female    64 testis, mated 4-day male    20 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    77 central nervous system, pupae P8    75 head, virgin 1-day female    44 head, virgin 4-day female    44 head, virgin 20-day female    24 head, mated 1-day female    49 head, mated 4-day female    38 head, mated 20-day female    24 head, mated 1-day male    59 head, mated 4-day male    54 head, mated 20-day male    51 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    46 digestive system, larvae L3 wandering    46 digestive system, 1-day adult    50 digestive system, 4-day adult    47 digestive system, 20-day adult    35 fat body, larvae L3 wandering    17 fat body, white prepupae    42 fat body, pupae P8    38 carcass, larvae L3 wandering    50 carcass, 1-day adult    60 carcass, 4-day adult    45 carcass, 20-day adult    31 ovary, virgin 4-day female    80 ovary, mated 4-day female    64 testis, mated 4-day male    20 accessory gland, mated 4-day male    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    77 central nervous system, pupae P8    75 head, virgin 1-day female    44 head, virgin 4-day female    44 head, virgin 20-day female    24 head, mated 1-day female    49 head, mated 4-day female    38 head, mated 20-day female    24 head, mated 1-day male    59 head, mated 4-day male    54 head, mated 20-day male    51 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    46 digestive system, larvae L3 wandering    46 digestive system, 1-day adult    50 digestive system, 4-day adult    47 digestive system, 20-day adult    35 fat body, larvae L3 wandering    17 fat body, white prepupae    42 fat body, pupae P8    38 carcass, larvae L3 wandering    50 carcass, 1-day adult    60 carcass, 4-day adult    45 carcass, 20-day adult    31 ovary, virgin 4-day female    80 ovary, mated 4-day female    64 testis, mated 4-day male    20 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3  (77) central nervous system, pupae P8  (75) head, virgin 1-day female  (44) head, virgin 4-day female  (44) head, virgin 20-day female    24 head, mated 1-day female  (49) head, mated 4-day female  (38) head, mated 20-day female    24 head, mated 1-day male  (59) head, mated 4-day male  (54) head, mated 20-day male  (51) salivary gland, larvae L3 wandering    19 salivary gland, white prepupae  (46) digestive system, larvae L3 wandering  (46) digestive system, 1-day adult  (50) digestive system, 4-day adult  (47) digestive system, 20-day adult  (35) fat body, larvae L3 wandering    17 fat body, white prepupae  (42) fat body, pupae P8  (38) carcass, larvae L3 wandering  (50) carcass, 1-day adult  (60) carcass, 4-day adult  (45) carcass, 20-day adult  31 ovary, virgin 4-day female  (80) ovary, mated 4-day female  (64) testis, mated 4-day male    20 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    77 central nervous system, pupae P8    75 head, virgin 1-day female    44 head, virgin 4-day female    44 head, virgin 20-day female    24 head, mated 1-day female    49 head, mated 4-day female    38 head, mated 20-day female    24 head, mated 1-day male    59 head, mated 4-day male    54 head, mated 20-day male    51 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    46 digestive system, larvae L3 wandering    46 digestive system, 1-day adult    50 digestive system, 4-day adult    47 digestive system, 20-day adult    35 fat body, larvae L3 wandering    17 fat body, white prepupae    42 fat body, pupae P8    38 carcass, larvae L3 wandering    50 carcass, 1-day adult    60 carcass, 4-day adult    45 carcass, 20-day adult    31 ovary, virgin 4-day female    80 ovary, mated 4-day female    64 testis, mated 4-day male    20 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    77 central nervous system, pupae P8    75 head, virgin 1-day female    44 head, virgin 4-day female    44 head, virgin 20-day female    24 head, mated 1-day female    49 head, mated 4-day female    38 head, mated 20-day female    24 head, mated 1-day male    59 head, mated 4-day male    54 head, mated 20-day male    51 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    46 digestive system, larvae L3 wandering    46 digestive system, 1-day adult    50 digestive system, 4-day adult    47 digestive system, 20-day adult    35 fat body, larvae L3 wandering    17 fat body, white prepupae    42 fat body, pupae P8    38 carcass, larvae L3 wandering    50 carcass, 1-day adult    60 carcass, 4-day adult    45 carcass, 20-day adult    31 ovary, virgin 4-day female    80 ovary, mated 4-day female    64 testis, mated 4-day male    20 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 12-24 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    37 embryo 04-06hr    28 embryo 06-08hr    32 embryo 08-10hr    44 embryo 10-12hr    26 embryo 12-14hr    52 embryo 14-16hr    23 embryo 16-18hr    37 embryo 18-20hr    23 embryo 20-22hr    34 embryo 22-24hr    53 larva L1    22 larva L2    27 larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    38 white prepupae new    50 white prepupae 12hr    67 white prepupae 24hr    40 pupae 2d postWPP    35 pupae 3d postWPP    35 pupae 4d postWPP    19 adult male 01day    31 adult male 05day    24 adult male 30day    17 adult female 01day    20 adult female 05day    36 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (33) embryo 02-04hr  (37) embryo 04-06hr  (28) embryo 06-08hr  (32) embryo 08-10hr  (44) embryo 10-12hr  26 embryo 12-14hr  (52) embryo 14-16hr    23 embryo 16-18hr  (37) embryo 18-20hr    23 embryo 20-22hr  (34) embryo 22-24hr  (53) larva L1    22 larva L2  (27) larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6  (27) larva L3 puffstage 7-9  (38) white prepupae new  (50) white prepupae 12hr  (67) white prepupae 24hr  (40) pupae 2d postWPP  (35) pupae 3d postWPP  (35) pupae 4d postWPP    19 adult male 01day  (31) adult male 05day    24 adult male 30day    17 adult female 01day    20 adult female 05day  (36) adult female 30day  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    37 embryo 04-06hr    28 embryo 06-08hr    32 embryo 08-10hr    44 embryo 10-12hr    26 embryo 12-14hr    52 embryo 14-16hr    23 embryo 16-18hr    37 embryo 18-20hr    23 embryo 20-22hr    34 embryo 22-24hr    53 larva L1    22 larva L2    27 larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    38 white prepupae new    50 white prepupae 12hr    67 white prepupae 24hr    40 pupae 2d postWPP    35 pupae 3d postWPP    35 pupae 4d postWPP    19 adult male 01day    31 adult male 05day    24 adult male 30day    17 adult female 01day    20 adult female 05day    36 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    37 embryo 04-06hr    28 embryo 06-08hr    32 embryo 08-10hr    44 embryo 10-12hr    26 embryo 12-14hr    52 embryo 14-16hr    23 embryo 16-18hr    37 embryo 18-20hr    23 embryo 20-22hr    34 embryo 22-24hr    53 larva L1    22 larva L2    27 larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    38 white prepupae new    50 white prepupae 12hr    67 white prepupae 24hr    40 pupae 2d postWPP    35 pupae 3d postWPP    35 pupae 4d postWPP    19 adult male 01day    31 adult male 05day    24 adult male 30day    17 adult female 01day    20 adult female 05day    36 adult female 30day    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    37 embryo 04-06hr    28 embryo 06-08hr    32 embryo 08-10hr    44 embryo 10-12hr    26 embryo 12-14hr    52 embryo 14-16hr    23 embryo 16-18hr    37 embryo 18-20hr    23 embryo 20-22hr    34 embryo 22-24hr    53 larva L1    22 larva L2    27 larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    38 white prepupae new    50 white prepupae 12hr    67 white prepupae 24hr    40 pupae 2d postWPP    35 pupae 3d postWPP    35 pupae 4d postWPP    19 adult male 01day    31 adult male 05day    24 adult male 30day    17 adult female 01day    20 adult female 05day    36 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (33) embryo 02-04hr  (37) embryo 04-06hr  28 embryo 06-08hr  32 embryo 08-10hr  (44) embryo 10-12hr  26 embryo 12-14hr  (52) embryo 14-16hr    23 embryo 16-18hr  (37) embryo 18-20hr    23 embryo 20-22hr  (34) embryo 22-24hr  (53) larva L1    22 larva L2  27 larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6  27 larva L3 puffstage 7-9  (38) white prepupae new  (50) white prepupae 12hr  (67) white prepupae 24hr  (40) pupae 2d postWPP  (35) pupae 3d postWPP  (35) pupae 4d postWPP    19 adult male 01day  31 adult male 05day    24 adult male 30day    17 adult female 01day    20 adult female 05day  (36) adult female 30day  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    37 embryo 04-06hr    28 embryo 06-08hr    32 embryo 08-10hr    44 embryo 10-12hr    26 embryo 12-14hr    52 embryo 14-16hr    23 embryo 16-18hr    37 embryo 18-20hr    23 embryo 20-22hr    34 embryo 22-24hr    53 larva L1    22 larva L2    27 larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    38 white prepupae new    50 white prepupae 12hr    67 white prepupae 24hr    40 pupae 2d postWPP    35 pupae 3d postWPP    35 pupae 4d postWPP    19 adult male 01day    31 adult male 05day    24 adult male 30day    17 adult female 01day    20 adult female 05day    36 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    37 embryo 04-06hr    28 embryo 06-08hr    32 embryo 08-10hr    44 embryo 10-12hr    26 embryo 12-14hr    52 embryo 14-16hr    23 embryo 16-18hr    37 embryo 18-20hr    23 embryo 20-22hr    34 embryo 22-24hr    53 larva L1    22 larva L2    27 larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    38 white prepupae new    50 white prepupae 12hr    67 white prepupae 24hr    40 pupae 2d postWPP    35 pupae 3d postWPP    35 pupae 4d postWPP    19 adult male 01day    31 adult male 05day    24 adult male 30day    17 adult female 01day    20 adult female 05day    36 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    100 Schneider line 2 Sg4    24 embryonic 1182-4H    40 embryonic GM2    126 embryonic Kc167    73 embryonic S1    52 embryonic S3    103 leg disc CME L1    40 wing disc CME-W2    98 wing disc ML-DmD8    38 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    53 wing disc ML-DmD21    18 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    105 ovary fGS/OSS    36 ovary OSC    44 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (100) Schneider line 2 Sg4    24 embryonic 1182-4H  (40) embryonic GM2  (126) embryonic Kc167  (73) embryonic S1  (52) embryonic S3  (103) leg disc CME L1  (40) wing disc CME-W2  (98) wing disc ML-DmD8  (38) wing disc ML-DmD9  (47) wing disc ML-DmD16-c3  (53) wing disc ML-DmD21    18 wing disc ML-DmD32  (33) haltere disc ML-DmD17-c3  (61) eye-antennal disc ML-DmD11  (40) antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1  (57) CNS ML-DmBG2-c2  (60) tumorous blood cells mbn2  (105) ovary fGS/OSS  (36) ovary OSC  (44) ovary OSS  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    100 Schneider line 2 Sg4    24 embryonic 1182-4H    40 embryonic GM2  (126) embryonic Kc167    73 embryonic S1    52 embryonic S3  103 leg disc CME L1    40 wing disc CME-W2    98 wing disc ML-DmD8    38 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    53 wing disc ML-DmD21    18 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2  105 ovary fGS/OSS    36 ovary OSC    44 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    100 Schneider line 2 Sg4    24 embryonic 1182-4H    40 embryonic GM2    126 embryonic Kc167    73 embryonic S1    52 embryonic S3    103 leg disc CME L1    40 wing disc CME-W2    98 wing disc ML-DmD8    38 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    53 wing disc ML-DmD21    18 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    105 ovary fGS/OSS    36 ovary OSC    44 ovary OSS    35 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    100 Schneider line 2 Sg4    24 embryonic 1182-4H    40 embryonic GM2    126 embryonic Kc167    73 embryonic S1    52 embryonic S3    103 leg disc CME L1    40 wing disc CME-W2    98 wing disc ML-DmD8    38 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    53 wing disc ML-DmD21    18 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    105 ovary fGS/OSS    36 ovary OSC    44 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (100) Schneider line 2 Sg4    24 embryonic 1182-4H  (40) embryonic GM2  (126) embryonic Kc167  (73) embryonic S1  (52) embryonic S3  (103) leg disc CME L1  (40) wing disc CME-W2  (98) wing disc ML-DmD8  (38) wing disc ML-DmD9  (47) wing disc ML-DmD16-c3  (53) wing disc ML-DmD21    18 wing disc ML-DmD32  (33) haltere disc ML-DmD17-c3  (61) eye-antennal disc ML-DmD11  (40) antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1  (57) CNS ML-DmBG2-c2  (60) tumorous blood cells mbn2  (105) ovary fGS/OSS  (36) ovary OSC  (44) ovary OSS  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    100 Schneider line 2 Sg4    24 embryonic 1182-4H    40 embryonic GM2  126 embryonic Kc167    73 embryonic S1    52 embryonic S3  103 leg disc CME L1    40 wing disc CME-W2    98 wing disc ML-DmD8    38 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    53 wing disc ML-DmD21    18 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2  105 ovary fGS/OSS    36 ovary OSC    44 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    100 Schneider line 2 Sg4    24 embryonic 1182-4H    40 embryonic GM2    126 embryonic Kc167    73 embryonic S1    52 embryonic S3    103 leg disc CME L1    40 wing disc CME-W2    98 wing disc ML-DmD8    38 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    53 wing disc ML-DmD21    18 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    105 ovary fGS/OSS    36 ovary OSC    44 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult    44 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    57 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    101 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    39 Caffeine 1.5 mg/ml 4 hrs, larvae L3    51 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    45 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult  (44) Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3  (57) Cadmium 50 mM 48 hrs, 4-day adult  (47) Cadmium 100 mM 48 hrs, 4-day adult  (75) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  (101) Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult  (84) Ethanol 2.5% 3 hrs, larvae L3  (51) Ethanol 5% 3 hrs, larvae L3  (56) Ethanol 10% 3 hrs, larvae L3  (39) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (51) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (72) Caffeine 25 mg/ml 48 hrs, 4-day adult  (27) Paraquat 5 mM 48 hrs, 4-day adult  (53) Paraquat 10 mM 48 hrs, 4-day adult  (43) Rotenone 2 μg 12 hrs, larvae L3  (45) Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult    44 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    57 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  101 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    39 Caffeine 1.5 mg/ml 4 hrs, larvae L3    51 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    45 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult    44 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    57 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    101 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    39 Caffeine 1.5 mg/ml 4 hrs, larvae L3    51 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    45 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult    44 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    57 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    101 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    39 Caffeine 1.5 mg/ml 4 hrs, larvae L3    51 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    45 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult  (44) Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3  (57) Cadmium 50 mM 48 hrs, 4-day adult  (47) Cadmium 100 mM 48 hrs, 4-day adult  (75) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  (101) Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult  (84) Ethanol 2.5% 3 hrs, larvae L3  (51) Ethanol 5% 3 hrs, larvae L3  (56) Ethanol 10% 3 hrs, larvae L3  (39) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (51) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (72) Caffeine 25 mg/ml 48 hrs, 4-day adult  27 Paraquat 5 mM 48 hrs, 4-day adult  (53) Paraquat 10 mM 48 hrs, 4-day adult  (43) Rotenone 2 μg 12 hrs, larvae L3  (45) Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult    44 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    57 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  101 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    39 Caffeine 1.5 mg/ml 4 hrs, larvae L3    51 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    45 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult    44 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    57 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    101 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    39 Caffeine 1.5 mg/ml 4 hrs, larvae L3    51 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    45 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RE55984 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024734 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4993-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | recessive, with Scer\GAL4[-]: PRL-1EP311 viable PRL-1EY11934 PRL-1EY15156 viable, with Scer\GAL4pnr-MD237 PRL-1GD10534 Sterility Allele fertile PRL-1EY11934 PRL-1EY15156 Other Phenotypes Allele wild-type, with Scer\GAL4[-]: PRL-1EP311 Phenotype manifest in Allele
Classical Alleles ( 24 )
For All Classical Alleles Show
Allele of PRL-1 Class Mutagen Stocks Known lesion PRL-1k09834 P-element activity 2 Yes PRL-15-SZ-4036 1 -- PRL-1c05314 1 -- PRL-1d03189 P-element activity 1 -- PRL-1d05234 1 -- PRL-1d08659 P-element activity 1 -- PRL-1EY11934 P-element activity 1 -- PRL-1EY15156 P-element activity 1 -- PRL-1f01274 piggyBac transposase 1 -- PRL-1NP2526 1 -- PRL-1NP4223 1 -- PRL-103264b P-element activity 0 Yes PRL-1B304 0 -- PRL-1c04016 piggyBac transposase 0 -- PRL-1c05267 piggyBac transposase 0 -- PRL-1d07756 P-element activity 0 -- PRL-1DG08803 0 -- PRL-1e02967 piggyBac transposase 0 -- PRL-1EIN133 FLPase 0 -- PRL-1EP2048 P-element activity 0 -- PRL-1EP2314 0 -- PRL-1EP311 P-element activity 0 Yes PRL-1f06562 piggyBac transposase 0 -- PRL-1GScE6 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of PRL-1 Class Mutagen Stocks Known lesion PRL-1GD10534 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes PRL-1HMS01826 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PRL-1KK108293 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Partially disrupted in	In(2L)EIN133 (Meadows et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10534} NA P{KK108293} NA P{TRiP.HMS01826} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}PRL-1EP311 NA P{EP}PRL-1EP2048 NA P{EP}PRL-1EP2314 NA P{EPgy2}PRL-1EY11934 NA P{EPgy2}PRL-1EY15156 NA P{GSV1}EndoGIGScE6 NA P{GSV1}EP-339EP-339 NA P{Mae-UAS.6.11}B0256B0256 NA P{XP}PRL-1d03189 NA P{XP}PRL-1d05234 NA P{XP}PRL-1d07756 NA P{XP}PRL-1d08659 NA insertion of enhancer trap P{lacW}l(2)SH0733SH0733 No P{lacW}PRL-1k09834 No P{PZ}PRL-103264b No miscellaneous insertions P{RS5}PRL-15-SZ-4036 NA P{wHy}PRL-1DG08803 NA PBac{5HPw+}PRL-1B304 NA PBac{PB}PRL-1c04016 NA PBac{PB}PRL-1c05267 NA PBac{PB}PRL-1c05314 NA PBac{RB}PRL-1e02967 NA PBac{WH}PRL-1f01274 NA PBac{WH}PRL-1f06562 NA insertion of enhancer trap binary system P{GawB}PRL-1NP2526 No P{GawB}PRL-1NP4223 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
prenylated protein tyrosine phosphatase activity inferred from sequence or structural similarity (Ashburner et al., 1999) non-traceable author statement (Zeng, 1998.5.6, Swiss-Prot Project Members, 1998.8.1) protein tyrosine/serine/threonine phosphatase activity inferred from electronic annotation with InterPro:IPR000340 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein dephosphorylation inferred from electronic annotation with InterPro:IPR000340 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1998.8.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions PRL-1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60964 DroID - A comprehensive database of gene and protein interactions. • FBgn0024734 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34952
Orthologs
OrthoDB Orthologs (52) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Z0BS5 Dipteran inclusive ortholog search EOG6DNFDN Insect inclusive ortholog search EOG6N5TT9 Arthropod inclusive ortholog search EOG67WM52 Metazoa inclusive ortholog search EOG66MQDR
Orthologs in Drosophila Species (EOG6Z0BS5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\PRL-1     Drosophila simulans   Dsim\GD21928 Y   Drosophila sechellia   Dsec\GM17919 Y   Drosophila erecta   Dere\GG24181 Y   Drosophila yakuba   Dyak\GE19374 Y   Drosophila ananassae   Dana\GF14943 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18577 Y   Drosophila persimilis   Dper\GL25773 Y   Drosophila willistoni   Dwil\GK14857 Y   Drosophila virilis   Dvir\GJ18218 Y   Drosophila mojavensis   Dmoj\GI17652 Y   Drosophila grimshawi   Dgri\GH13415 Y
Orthologs in non-Drosophila Dipterans (EOG6DNFDN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001798   Anopheles gambiae Malaria mosquito  Agam\AGAP008708   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001969
Orthologs in non-Dipteran Insects (EOG6N5TT9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Prl-1   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013980   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13194   Atta cephalotes Leafcutter ant  Acep\ACEP12395   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21782   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17381   Linepithema humile Argentine ant  Lhum\LH24503   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15855   Solenopsis invicta Red fire ant  Sinv\SINV10784   Acyrthosiphon pisum Pea aphid  Apim\ACYPI071956   Bombyx mori Silkmoth  Bmor\BGIBMGA003584   Pediculus humanus Human body louse  Phum\PHUM616220   Tribolium castaneum Red flour beetle  Tcas\TC004794
Orthologs in non-Insect Arthropods (EOG67WM52)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_305822   Ixodes scapularis Deer tick  Isca\ISCW015996
Orthologs in non-Arthropod Metazoa (EOG66MQDR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\prl-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008895gn   Danio rerio Zebrafish  Drer\zgc:91861   Danio rerio Zebrafish  Drer\CH211-197N10.3   Danio rerio Zebrafish  Drer\ptp4a1   Danio rerio Zebrafish  Drer\ptp4a3   Danio rerio Zebrafish  Drer\si:ch211-251p5.5   Xenopus tropicalis Western clawed frog  Xtro\ptp4a2   Xenopus tropicalis Western clawed frog  Xtro\ptp4a3   Xenopus tropicalis Western clawed frog  Xtro\ptp4a1   Gallus gallus Domestic chicken  Ggal\PTP4A3   Gallus gallus Domestic chicken  Ggal\PTP4A1   Gallus gallus Domestic chicken  Ggal\PTP4A2   Mus musculus House mouse  Mmus\Ptp4a3   Mus musculus House mouse  Mmus\Ptp4a1   Mus musculus House mouse  Mmus\Ptp4a2   Rattus norvegicus Norway rat  Rnor\Ptp4a1   Rattus norvegicus Norway rat  Rnor\Ptp4a3   Rattus norvegicus Norway rat  Rnor\RGD1563405   Homo sapiens Human  Hsap\PTP4A2   Homo sapiens Human  Hsap\PTP4A1   Homo sapiens Human  Hsap\PTP4A3
Human Orthologs (3)
Gene OMIM HGNC Hsap\PTP4A2     Hsap\PTP4A1     Hsap\PTP4A3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21928 Drosophila sechellia Dsec\GM17919 Drosophila erecta Dere\GG24181 Drosophila yakuba Dyak\GE19374 Drosophila ananassae Dana\GF14943 Drosophila pseudoobscura pseudoobscura Dpse\GA18577 Drosophila persimilis Dper\GL25773 Drosophila willistoni Dwil\GK14857 Drosophila virilis Dvir\GJ18218 Drosophila mojavensis Dmoj\GI17652 Drosophila grimshawi Dgri\GH13415
Stocks & Reagents
Stocks Listed in FlyBase ( 17 )
Bloomington	20713 y1 w67c23; P{EPgy2}PRL-1EY11934
Harvard	- P{XP}PRL-1d03189 - P{XP}PRL-1d05234 - P{XP}PRL-1d08659 - PBac{PB}PRL-1c05314 - PBac{WH}PRL-1f01274
Kyoto	126299 w1118; P{RS5}PRL-15-SZ-4036 112951 w*; P{GawB}PRL-1NP2526 / CyO
VDRC	v107836 P{KK108293}VIE-260B v21558 w1118 P{GD10534}v21558 v45863 w1118 P{GD10534}v45863 v45518 w1118; P{GD10534}v45518/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR21C10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 322 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE40268 RE55984
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03107 GH07903 GH12205 GH12217 GM07690 GM14563 GM14708 GM14720 LD12894 LD18273 LD20164 LD33906 LD33945 LD33967 LD34413 LD36046 LD45205 RE04790 RE05369 RE05462 RE06510 RE08693 RE14130 RE15233 RE21404 RE21416 RE23583 RE23952 RE24304 RE29165 RE29974 RE30134 RE31865 RE33530 RE33894 RE33976 RE37349 RE37551 RE39745 RE41027 RE44904 RE49252 RE49764 RE50255 RE50261 RE50268 RE51152 RE51867 RE51870 RE52941 RE58055 RE63411 RE64175 RE64483 RE65444 RE66056 RE67176 RE72253 RE73835 RH46187 SD19445
Other clones	1442 11672 12280 12583 18081 28343 28817 28911 29103 31708 33245 33872 38173 39427 43330 45062 45171 45904 47782 52166 53842 55095 57432 57616 58020 58480 58789 60041 61347 62372 66016 71023 74009 74479 74538 74545 74596 75362 76122 76398 77338 78077 78526 80977 82434 99654 107931 108881 117646 120386 122238 124528 124987 125097 147581 147825 156529 156725 157355 161923 163408 165918 172470 173014 179588 190801 193597 194636 194794 214313.26 214379.19 214437.36 273828 275277 277217 282417 473460 576505 CK01.17B.G2 CK01.19B.A8 CK01.19B.C8 CK01.25B.F9 CK01.26C.C5 CK01.30B.F5 CK01.39D.F2 CK01.49B.F6 CK01.59D.E7 CK01.63A.B10 CK01.71C.C4 CK01.76A.D2 CK01.76C.A2 CK01.84B.E4 CK01.85A.H4 CK01.91A.H7 CK01.94A.A12 CK01.95A.F2 CK01.97C.H12 CK01.100B.D9 CK01.109A.F12 CK01.111A.B2 CK01.112C.A8 CK01.112C.B8 CK01.120A.E5 CK01.123A.F6 CK01.144C.D2 CK00486 Dmel_dig_010301_0686_2120 Dmel_neb_014804_0651_0799 EC14201 EC051381 EC051447 EC054430 EC054440 EC056047 EK001736 EK018136 EK018144 EK019408 EK022423 EK023211 EK025209 EK045740 EK048320 EK056732 EK059445 EK059825 EK067462 EK068850 EK071332 EK073334 EK073940 EK075662 EK076105 EK077313 EK088702 EK088911 EK091619 EK093755 EK098754 EK099136 EK112154 EK112724 EK113952 EK119145 EK122544 EK135964 EK136918 EK136947 EK137046 EK137204 EK141241 EK143643 EK144401 EK148319 EK150844 EK152624 EK155603 EK159119 EK160751 EK160855 EK162317 EK162721 EK166527 EK166663 EK166744 EK171615 EK174745 EK175744 EK178510 EK180244 EK180922 EK182839 EK183009 EK184704 EK184764 EK187514 EK193651 EK194505 EK199045 EK203627 EK207817 EK210650 EK214541 EK215563 EK221954 EK222308 EK223729 EK227756 EK234186 EK235264 EK238609 EK242106 EK247214 EK252756 EK253154 EK256805 EK259628 EK260342 EK270454 EK273319 EK284435 EK293353 EK302334 EK303130 EK304108 EK304114 EK308142 EN00116 EN00314 EN17406 EN17819 EP01959 EP04335 FGA001E09 FGC012A11 FGC030F10 FGM102G03 FGM221E09 FGM224B10 FGM310A04 LD39844 RP003030185 RP003031851 RP003053018 RP003061264 RP003066922 RP003084044 RP003088673 RP003094949 RP003096011 RP003101182 RP003106195 RP003108905 RP003145280 RP003170355 RP003184766 RP003185900 RP003201200 RP003205808 RP003227752 RP003244242 RP003283797 RP003301172 RP003302564 RP003303788 RP003310466 RP003323946 RP003342352 RP003357905 RP003365544 RP003365840 RP003372930 RP003373947 RP003415572 RP003547059 RP003558825 RP003649508 RP003651728 unknown
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024734 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34952
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: PRL-1 CG4993 (Kodira, 1999.11)
Source for database merge of	Source for merge of: PRL-1 BcDNA:RE40268 (FlyBase, 1996-)
Additional comments	Source for merge of PRL-1 BcDNA:RE40268 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	Data suggests that PRL-1 is not a vital gene. (Ashburner et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135936 NM_165150 NM_001273558 NM_001273559 RefSeq (Proteins) • NP_609780 NP_723956 NP_001260487 NP_001260488 DDBJ / EMBL / GenBank • AA140816 AA392622 AA538688 AA540959 AA696442 AA803899 AA821150 AA821153 AA979376 AA979397 AA979413 AA990900 AAC16552 AAF44989 AAF53506 AAL26988 AAL49127 AAM11225 AAN10934 AE003415 AF063902 AF390535 AGB93022 AGB93023 AI063355 AQ025903 AQ025971 AQ073277 AQ074056 AY071505 AY094872 BI242832 BI369716 CL868533 CL943678 CZ468961 CZ469834 CZ473225 CZ475914 CZ475915 CZ476352 CZ476353 CZ480735 CZ483748 CZ489273 CZ489274 Entrez Gene - A searchable database of RefSeq genes. • 34952 UniProtKB/TrEMBL • O61722 Q7KPK2 Q8SX36 Q95VY8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein-tyrosine/Dual specificity phosphatase (IPR000387) Dual specificity phosphatase, catalytic domain (IPR000340) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE55984
Linkouts
	BioGRID - A database of protein and genetic interactions • 60964 DroID - A comprehensive database of gene and protein interactions. • FBgn0024734 DRSC - Results from RNAi screens. • FBgn0024734 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024734 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4993-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024734 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34952 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34952 modMine - Data generated by the modENCODE project. • FBgn0024734
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	BcDNA:RE40268   BG:DS07473.3 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) CG4993 (Morrison et al., 2000, Moorman et al., 2006, Molnar et al., 2006, Grieder et al., 2007, Keleman et al., 2009.8.5, Brandt, 2006, Cammarato et al., 2011, Ni et al., 2010.12.1) PRL (Morrison et al., 2000) PRL-1 (FlyBase Curators, 2008, O'Keefe et al., 2011, Grieder et al., 2007, Gan et al., 2010, Gonsalves et al., 2011, Brandt, 2006, Rehwinkel et al., 2005, Birch-Machin et al., 2005, Buffin and Gho, 2010, Friedman et al., 2011, Meadows et al., 2010) PrL-1 (Molnar et al., 2006)
Name Synonym	PRL-1 (Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0027875 FBgn0062445
References ( 44 )
Generate a list of	All references relating to this gene ( 44 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 12 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 3 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 )
Recent research papers ( 4 )
	Friedman et al., 2011, Sci. Signal. 4(196): rs10 Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. [FBrf0216513] Gonsalves et al., 2011, BMC Genomics 12: 475 Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster. [FBrf0216487] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] O'Keefe et al., 2011, Mech. Dev. 128(1-2): 59--70 EndoGI modulates Notch signaling and axon guidance in Drosophila. [FBrf0213012] Show all research papers ...