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Gene Dere\eve

General Information
Symbol	Dere\eve	Species	D. erecta
Name		Annotation symbol	GG24126
Feature type	protein_coding_gene	FlyBase ID	FBgn0024802
Gene Model Status	Current	Stock availability	None publicly available
Also Known As	eve
Genomic Location
Chromosome (arm)	scaffold_4929	Recombination map
Cytogenetic map		Sequence location	scaffold_4929:8,501,001..8,502,210 [-]
Genomic Maps	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dere\eve (GG24126, FBgn0024802). It is a protein_coding_gene from Drosophila erecta. An electronic pipeline based on InterPro domains suggests that it has the molecular function: sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: regulation of transcription, DNA-dependent. No alleles are reported. It has one annotated transcript and one annotated polypeptide. Protein features are: Homeobox, conserved site; Homeodomain; Homeodomain, metazoa; Homeodomain-like. Gene sequence location is scaffold_4929:8501001..8502210.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dere\eve for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dere\eve-RA FBtr0144180  XM_001969080   1137   378
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dere\eve-PA   FBpp0142672   40.2   378   9.73     XP_001969116   EDV58175
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeodomain (IPR001356) Homeodomain-like (IPR009057) Homeodomain, metazoa (IPR020479)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AF042711   AY190939 AAO01003   CH954177 EDV58175
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8I1G6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Dere\eve Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dere\eve Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR017970 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from electronic annotation with InterPro:IPR001356 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR012287, InterPro:IPR017970 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR017970 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene (Drosophila 12 Genomes Consortium, 2008) protein_coding_gene (Drosophila 12 Genomes Consortium, 2008)
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dere\eve allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (1) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63N809 Dipteran inclusive ortholog search EOG6XKVHB Insect inclusive ortholog search EOG65QG9W Arthropod inclusive ortholog search EOG6KH1BP Metazoa inclusive ortholog search EOG6J1D3C
Ortholog(s) in Drosophila melanogaster (EOG63N809)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\eve Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (1) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila melanogaster Dmel\eve
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • XM_001969080 RefSeq (Proteins) • XP_001969116 DDBJ / EMBL / GenBank • AAO01003 AF042711 AY190939 EDV58175 Entrez Gene - A searchable database of RefSeq genes. • 6541346 UniProtKB/TrEMBL • Q8I1G6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeodomain (IPR001356) Homeodomain-like (IPR009057) Homeodomain, metazoa (IPR020479)
Linkouts
	FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024802
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	dere_GLEANR_8884 (Drosophila 12 Genomes Consortium, 2008) Dere\eve (Drosophila 12 Genomes Consortium, 2008, ) eve (Drosophila 12 Genomes Consortium, 2008, Satija et al., 2009, Moses, 2009, Hare et al., 2008, Satija et al., 2008)
Name Synonym	even-skipped (Zhang et al., 2004)
Secondary FlyBase IDs
References ( 19 )
Research paper	Moses, 2009, BMC Evol. Biol. 9: 286 Statistical tests for natural selection on regulatory regions based on the strength of transcription factor binding sites. [FBrf0209604] Satija et al., 2009, BMC Evol. Biol. 9: 217 BigFoot: Bayesian alignment and phylogenetic footprinting with MCMC. [FBrf0208856] Hare et al., 2008, PLoS Genet. 4(6): e1000106 Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation. [FBrf0205215] Satija et al., 2008, Bioinformatics 24(10): 1236--1242 Combining statistical alignment and phylogenetic footprinting to detect regulatory elements. [FBrf0205205] Drosophila 12 Genomes Consortium et al., 2007, Nature 450(7167): 203--218 Evolution of genes and genomes on the Drosophila phylogeny. [FBrf0200326] Ludwig, 2005, PLoS Biol. 3(4): e93 Functional Evolution of a cis-Regulatory Module. [FBrf0188414] Zhang et al., 2004, Mol. Biol. Evol. 21(11): 2130--2139 Molecular evolution of sex-biased genes in Drosophila. [FBrf0180516] Andrioli et al., 2002, Development 129(21): 4931--4940 Anterior repression of a Drosophila stripe enhancer requires three position-specific mechanisms. [FBrf0151930] Bergman et al., 2002, Genome Biol. 3(12): RESEARCH0086 Assessing the impact of comparative genomic sequence data on the functional annotation of the Drosophila genome. [FBrf0155470] Ludwig et al., 2000, Nature 403(6769): 564--567 Evidence for stabilizing selection in a eukaryotic enhancer element. [FBrf0125388] Ludwig et al., 1998, Development 125(5): 949--958 Functional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change. [FBrf0101944]
Review	Anonymous, 2005, PLoS Biol. 3(4): e138 Plus Ça Change: Gene Enhancers Upset Evolutionary Assumption. [FBrf0188412] Ludwig, 2002, Curr. Opin. Genet. Dev. 12(6): 634--639 Functional evolution of noncoding DNA. [FBrf0155646] Simpson, 2002, Nat. Rev. Genet. 3(12): 907--917 Evolution of development in closely related species of flies and worms. [FBrf0155986]
Personal communication to FlyBase	Drosophila 12 Genomes Consortium, 2008, personal communication to FlyBase Symbols and class of gene information for the GLEANR consensus sequences of the 11 sequenced non-melanogaster Drosophila species (Drosophila ananassae, erecta, grimshawi, mojavensis, persimilis, pseudoobscura, sechellia, simulans, willistoni, virilis and yakuba). [FBrf0202436] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Abstract	Ludwig et al., 2004, A. Dros. Res. Conf. 45: 146 Functional divergence of eve stripe 2 enhancer in the Drosophila melanogaster species subgroup. [FBrf0173412] Bergman et al., 2003, A. Dros. Res. Conf. 44: 860B Assessing the impact of comparative genomic sequence data on the functional annotation of the Drosophila genome. [FBrf0154526]
FlyBase analysis	FlyBase, 2008, Newly sequenced Drosophila genomes: associations of GLEANR gene predictions (Releases 1.0) with previously known genes in FlyBase. Newly sequenced Drosophila genomes: associations of GLEANR gene predictions (Releases 1.0) with previously known genes in FlyBase. [FBrf0202439]