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Gene Dmel\Dbp80

General Information
Symbol	Dmel\Dbp80	Species	D. melanogaster
Name	Dead box protein 80	Annotation symbol	CG17023
Feature type	protein_coding_gene	FlyBase ID	FBgn0024804
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3LHet	Recombination map
Cytogenetic map	80F-80F	Sequence location	3LHet:2,409,852..2,545,146 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dead box protein 80 is referred to in FlyBase by the symbol Dmel\Dbp80 (CG17023, FBgn0024804). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: ATP-dependent RNA helicase activity. The biological processes in which it is involved are not known. 7 alleles are reported. No phenotypic data is available. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; Helicase, superfamily 1/2, ATP-binding domain; RNA helicase, DEAD-box type, Q motif. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of Dbp80. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of Dbp80. Gene sequence location is 3LHet:2409852..2545146.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 80F-80F   Left limit from sequence databank entry AF005239 Right limit from sequence databank entry AF005239
Experimentally Determined Cytological Location
Cytogenetic map Notes References 80F-80F   h53--h55   (Drosophila Heterochromatin Genome Project, 2004) 80F-80F     (Eisen, 1997.5.23) 80-80   (determined by in situ hybridisation)   (Eisen et al., 1998) h47-h53L   (determined by in situ hybridisation)   (Neal, 1997.4.17)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dbp80 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dbp80-RB FBtr0113715  NM_001015151   1459   447 Dbp80-RC FBtr0113716  NM_001110962   701   213 Dbp80-RD FBtr0331780  NM_001015152   1204   279 Dbp80-RE FBtr0331781  NM_001276239   1505   481 Dbp80-RF FBtr0331782  NM_001276240   1458   316 Dbp80-RG FBtr0331783  NM_001276241   1564   354 Dbp80-RH FBtr0331784  NM_001276242   1505   481
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dbp80-PB   FBpp0112438   50.1   447   8.61     NP_001015151   EAL24621 Dbp80-PC   FBpp0112439   23.9   213   10.49     NP_001104432   EDP28097 Dbp80-PD   FBpp0304165   31.0   279   7.57     NP_001015152   EAA46272 Dbp80-PE   FBpp0304166   53.5   481   6.73     NP_001263168   ELP57413 Dbp80-PF   FBpp0304167   35.7   316   6.93     NP_001263169   ELP57414 Dbp80-PG   FBpp0304168   39.7   354   7.67     NP_001263170   ELP57415 Dbp80-PH   FBpp0304169   53.5   481   6.73     NP_001263171   ELP57416
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Helicase, C-terminal (IPR001650) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) RNA helicase, DEAD-box type, Q motif (IPR014014)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264888   AA391525   AA438781   AA695645   AA801868   AABU01002497 EAA46272   AF005239   AI109076   AI134735   AI402564   AI403841   AI517103   AY071389   AY094931   BI216311   BI229286   BI229306   BI242459   BI357647   BI363932   BI364657   BI365488   BI367021   BI370943   BI565289   BI565971   BI587525   BI589092   BI592375   BI608209   BI620314   BI627380   BI629043   BI634965   BP546713   BT132784   CK133168   CK133948   CK134696   CK661276   CO153548   CO184918   CO193815   CO264430   CO265017   CO269573   CO279302   CO283301   CO290364   CO297335   CO302281   CO302951   CO309686   CO322405   CO323493   CO339549   CO341580   CM000458 EAA46272   CM000458 EAL24621   EC052564   EC052570   EC053080   EC056375   EC064522   EC081760   EC082801   EC082808   EC201893   EC214519   EC229027   EC264557   CM000458 EDP28097   CM000458 ELP57413   CM000458 ELP57414   CM000458 ELP57415   CM000458 ELP57416   ES696532   EV597211
UniProtKB/Swiss-Prot	O61305
UniProtKB/TrEMBL	A8Y564 Q5LK13 Q8SYQ3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    50 central nervous system, pupae P8    52 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    13 head, mated 1-day male    29 head, mated 4-day male    29 head, mated 20-day male    27 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    14 carcass, larvae L3 wandering    37 carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    16 ovary, virgin 4-day female    60 ovary, mated 4-day female    37 testis, mated 4-day male    15 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (48) central nervous system, larvae L3  (50) central nervous system, pupae P8  (52) head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    13 head, mated 1-day male  (29) head, mated 4-day male  (29) head, mated 20-day male  (27) salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    18 digestive system, larvae L3 wandering  (28) digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    14 carcass, larvae L3 wandering  (37) carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    16 ovary, virgin 4-day female  (60) ovary, mated 4-day female  (37) testis, mated 4-day male    15 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    50 central nervous system, pupae P8    52 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    13 head, mated 1-day male    29 head, mated 4-day male    29 head, mated 20-day male    27 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    14 carcass, larvae L3 wandering    37 carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    16 ovary, virgin 4-day female    60 ovary, mated 4-day female    37 testis, mated 4-day male    15 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    50 central nervous system, pupae P8    52 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    13 head, mated 1-day male    29 head, mated 4-day male    29 head, mated 20-day male    27 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    14 carcass, larvae L3 wandering    37 carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    16 ovary, virgin 4-day female    60 ovary, mated 4-day female    37 testis, mated 4-day male    15 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    50 central nervous system, pupae P8    52 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    13 head, mated 1-day male    29 head, mated 4-day male    29 head, mated 20-day male    27 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    14 carcass, larvae L3 wandering    37 carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    16 ovary, virgin 4-day female    60 ovary, mated 4-day female    37 testis, mated 4-day male    15 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (48) central nervous system, larvae L3  (50) central nervous system, pupae P8  (52) head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    13 head, mated 1-day male  29 head, mated 4-day male  29 head, mated 20-day male  27 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    18 digestive system, larvae L3 wandering  28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    14 carcass, larvae L3 wandering  (37) carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    16 ovary, virgin 4-day female  (60) ovary, mated 4-day female  (37) testis, mated 4-day male    15 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    50 central nervous system, pupae P8    52 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    13 head, mated 1-day male    29 head, mated 4-day male    29 head, mated 20-day male    27 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    14 carcass, larvae L3 wandering    37 carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    16 ovary, virgin 4-day female    60 ovary, mated 4-day female    37 testis, mated 4-day male    15 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    50 central nervous system, pupae P8    52 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    16 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    13 head, mated 1-day male    29 head, mated 4-day male    29 head, mated 20-day male    27 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    28 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    14 carcass, larvae L3 wandering    37 carcass, 1-day adult    12 carcass, 4-day adult    17 carcass, 20-day adult    16 ovary, virgin 4-day female    60 ovary, mated 4-day female    37 testis, mated 4-day male    15 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    29 embryo 04-06hr    33 embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    6 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    30 white prepupae new    27 white prepupae 12hr    21 white prepupae 24hr    21 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    7 adult male 30day    7 adult female 01day    6 adult female 05day    18 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr  (29) embryo 04-06hr  (33) embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    6 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9  (30) white prepupae new  (27) white prepupae 12hr    21 white prepupae 24hr    21 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    7 adult male 30day    7 adult female 01day    6 adult female 05day    18 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    29 embryo 04-06hr    33 embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    6 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    30 white prepupae new    27 white prepupae 12hr    21 white prepupae 24hr    21 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    7 adult male 30day    7 adult female 01day    6 adult female 05day    18 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    29 embryo 04-06hr    33 embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    6 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    30 white prepupae new    27 white prepupae 12hr    21 white prepupae 24hr    21 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    7 adult male 30day    7 adult female 01day    6 adult female 05day    18 adult female 30day    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    29 embryo 04-06hr    33 embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    6 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    30 white prepupae new    27 white prepupae 12hr    21 white prepupae 24hr    21 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    7 adult male 30day    7 adult female 01day    6 adult female 05day    18 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr  29 embryo 04-06hr  (33) embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    6 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9  30 white prepupae new  27 white prepupae 12hr    21 white prepupae 24hr    21 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    7 adult male 30day    7 adult female 01day    6 adult female 05day    18 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    29 embryo 04-06hr    33 embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    6 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    30 white prepupae new    27 white prepupae 12hr    21 white prepupae 24hr    21 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    7 adult male 30day    7 adult female 01day    6 adult female 05day    18 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    29 embryo 04-06hr    33 embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    22 embryo 14-16hr    7 embryo 16-18hr    13 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    12 larva L1    6 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    30 white prepupae new    27 white prepupae 12hr    21 white prepupae 24hr    21 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    7 adult male 30day    7 adult female 01day    6 adult female 05day    18 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    83 Schneider line 2 Sg4    55 embryonic 1182-4H    40 embryonic GM2    138 embryonic Kc167    64 embryonic S1    23 embryonic S3    70 leg disc CME L1    35 wing disc CME-W2    138 wing disc ML-DmD8    48 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    52 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    50 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    41 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    61 ovary fGS/OSS    34 ovary OSC    50 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (83) Schneider line 2 Sg4  (55) embryonic 1182-4H  (40) embryonic GM2  (138) embryonic Kc167  (64) embryonic S1    23 embryonic S3  (70) leg disc CME L1  (35) wing disc CME-W2  (138) wing disc ML-DmD8  (48) wing disc ML-DmD9  (41) wing disc ML-DmD16-c3  (37) wing disc ML-DmD21  (52) wing disc ML-DmD32  (66) haltere disc ML-DmD17-c3  (76) eye-antennal disc ML-DmD11  (50) antennal disc ML-DmD20-c5  (37) mixed discs ML-DmD4-c1  (41) CNS ML-DmBG1-c1  (30) CNS ML-DmBG2-c2  (38) tumorous blood cells mbn2  (61) ovary fGS/OSS  (34) ovary OSC  (50) ovary OSS  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    83 Schneider line 2 Sg4    55 embryonic 1182-4H    40 embryonic GM2  (138) embryonic Kc167    64 embryonic S1    23 embryonic S3    70 leg disc CME L1    35 wing disc CME-W2  (138) wing disc ML-DmD8    48 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    52 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    50 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    41 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    61 ovary fGS/OSS    34 ovary OSC    50 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    83 Schneider line 2 Sg4    55 embryonic 1182-4H    40 embryonic GM2    138 embryonic Kc167    64 embryonic S1    23 embryonic S3    70 leg disc CME L1    35 wing disc CME-W2    138 wing disc ML-DmD8    48 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    52 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    50 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    41 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    61 ovary fGS/OSS    34 ovary OSC    50 ovary OSS    45 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    83 Schneider line 2 Sg4    55 embryonic 1182-4H    40 embryonic GM2    138 embryonic Kc167    64 embryonic S1    23 embryonic S3    70 leg disc CME L1    35 wing disc CME-W2    138 wing disc ML-DmD8    48 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    52 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    50 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    41 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    61 ovary fGS/OSS    34 ovary OSC    50 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (83) Schneider line 2 Sg4  (55) embryonic 1182-4H  (40) embryonic GM2  (138) embryonic Kc167  (64) embryonic S1    23 embryonic S3  (70) leg disc CME L1  (35) wing disc CME-W2  (138) wing disc ML-DmD8  (48) wing disc ML-DmD9  (41) wing disc ML-DmD16-c3  (37) wing disc ML-DmD21  (52) wing disc ML-DmD32  (66) haltere disc ML-DmD17-c3  (76) eye-antennal disc ML-DmD11  (50) antennal disc ML-DmD20-c5  (37) mixed discs ML-DmD4-c1  (41) CNS ML-DmBG1-c1  30 CNS ML-DmBG2-c2  (38) tumorous blood cells mbn2  (61) ovary fGS/OSS  (34) ovary OSC  (50) ovary OSS  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    83 Schneider line 2 Sg4    55 embryonic 1182-4H    40 embryonic GM2  138 embryonic Kc167    64 embryonic S1    23 embryonic S3    70 leg disc CME L1    35 wing disc CME-W2  138 wing disc ML-DmD8    48 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    52 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    50 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    41 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    61 ovary fGS/OSS    34 ovary OSC    50 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    83 Schneider line 2 Sg4    55 embryonic 1182-4H    40 embryonic GM2    138 embryonic Kc167    64 embryonic S1    23 embryonic S3    70 leg disc CME L1    35 wing disc CME-W2    138 wing disc ML-DmD8    48 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    52 wing disc ML-DmD32    66 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    50 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    41 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    61 ovary fGS/OSS    34 ovary OSC    50 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    47 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3  (45) Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult  (47) Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult  (33) Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3  (31) Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (40) Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3  (27) Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    47 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    47 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    47 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3  (45) Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult  (47) Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult  (33) Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3  31 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (40) Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3  27 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    47 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    47 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    40 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RE44177 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024804 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17023-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Dbp80 Class Mutagen Stocks Known lesion Dbp80G20457 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dbp80 Class Mutagen Stocks Known lesion Dbp80HMS01160 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dbp80dsRNA.C in vitro construct - RNAi 0 Yes Dbp80dsRNA.N in vitro construct - RNAi 0 Yes Dbp80dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Dbp80KK115472 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Dbp80MtnA.PE in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)9-56 (Schulze et al., 2005) Df(3L)K-2 (Schulze et al., 2005)
Not disrupted in	Df(3L)Snap253 (Schulze et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK115472} NA P{TRiP.HMS01160} NA P{UAS-Dbp80.RNAi} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Dbp80G20457 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR001650, InterPro:IPR011545 (FlyBase Curators et al., 2004-) ATP-dependent helicase activity inferred from electronic annotation with InterPro:IPR011545 (FlyBase Curators et al., 2004-) ATP-dependent RNA helicase activity non-traceable author statement (Swiss-Prot Project Members, 2001.8.20) nucleic acid binding inferred from electronic annotation with InterPro:IPR001650, InterPro:IPR011545 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nuclear pore cytoplasmic filaments inferred from sequence or structural similarity with Saccharomyces DBP5 (Curators, 2008--)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Dbp80 - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dbp80 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0024804 DroID - A comprehensive database of gene and protein interactions. • FBgn0024804 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3354919
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6QJS6Z Dipteran inclusive ortholog search EOG6PRT04 Insect inclusive ortholog search EOG6NK9QX Arthropod inclusive ortholog search EOG6XSJ55 Metazoa inclusive ortholog search EOG6RJTTW
Orthologs in Drosophila Species (EOG6QJS6Z)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Dbp80     Drosophila simulans   Dsim\GD11942     Drosophila erecta   Dere\GG16328     Drosophila yakuba   Dyak\GE19740     Drosophila ananassae   Dana\GF20554     Drosophila persimilis   Dper\GL21967     Drosophila willistoni   Dwil\GK12237     Drosophila virilis   Dvir\Dbp80     Drosophila mojavensis   Dmoj\GI13776     Drosophila grimshawi   Dgri\GH15125
Orthologs in non-Drosophila Dipterans (EOG6PRT04)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009913   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012015   Anopheles gambiae Malaria mosquito  Agam\AGAP003397   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003743
Orthologs in non-Dipteran Insects (EOG6NK9QX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Dbp80   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG027751   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG027749   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24825   Atta cephalotes Leafcutter ant  Acep\ACEP19773   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13185   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20655   Linepithema humile Argentine ant  Lhum\LH18441   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24932   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000979   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003011   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004253   Bombyx mori Silkmoth  Bmor\BGIBMGA001223   Pediculus humanus Human body louse  Phum\PHUM497940   Tribolium castaneum Red flour beetle  Tcas\TC014047
Orthologs in non-Insect Arthropods (EOG6XSJ55)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_306525   Ixodes scapularis Deer tick  Isca\ISCW005709
Orthologs in non-Arthropod Metazoa (EOG6RJTTW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ddx-19   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028284gn   Danio rerio Zebrafish  Drer\zgc:193690   Danio rerio Zebrafish  Drer\ddx19   Xenopus tropicalis Western clawed frog  Xtro\ddx19b   Xenopus tropicalis Western clawed frog  Xtro\ddx25   Gallus gallus Domestic chicken  Ggal\ENSGALG00000000463   Gallus gallus Domestic chicken  Ggal\DDX19B   Mus musculus House mouse  Mmus\Ddx19a   Mus musculus House mouse  Mmus\Ddx19b   Mus musculus House mouse  Mmus\Ddx25   Rattus norvegicus Norway rat  Rnor\Ddx25   Rattus norvegicus Norway rat  Rnor\Ddx19a   Homo sapiens Human  Hsap\DDX19B   Homo sapiens Human  Hsap\DDX19A   Homo sapiens Human  Hsap\ENSG00000109832
Human Orthologs (3)
Gene OMIM HGNC Hsap\DDX19B     Hsap\DDX19A     Hsap\ENSG00000109832
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	34682 y1 sc* v1; P{TRiP.HMS01160}attP2 31866 w1118; P{EP}Dbp80G20457/TM6C, Sb1
Genomic Clones ( 0 )
cDNA Clones ( 24 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH50880
Other clones	DPiM_RE44177 FI16114 RE44177
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH12273 GH23367 GH27739 RE17686 RE72565 RH10041 RH28220 RH30769 RH39948 RH68672
Other clones	Dmel_neb_014994_0944_1709 EC28789 EK134008 EK141239 EK162816 EK183818 EK185229 EK188051 EK190617 EP02234
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024804 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3354919
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Dbp80 BcDNA:RE44177 (FlyBase, 1996-) Source for merge of: Dbp80 CG17023 (Drosophila Heterochromatin Genome Project, 2004)
Additional comments	"vtd" does not correspond to "Dbp80". "l(3)80Fj" does not correspond to "Dbp80". (Schulze et al., 2005)
Other Comments
	mle is used as a 'bait' in the yeast two-hybrid system to screen for interactors from an imaginal disc cDNA library: Dbp80 is identified. (Eisen et al., 1998) Isolated as an mle interacting protein using the yeast two-hybrid system. (Eisen et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001015151 NM_001015152 NM_001110962 NM_001276239 NM_001276240 NM_001276241 NM_001276242 RefSeq (Proteins) • NP_001015151 NP_001015152 NP_001104432 NP_001263168 NP_001263169 NP_001263170 NP_001263171 DDBJ / EMBL / GenBank • AABU01002497 AAC23709 AAL49011 AF005239 AY071389 BI357647 EAA46272 EAL24621 EDP28097 ELP57413 ELP57414 ELP57415 ELP57416 Entrez Gene - A searchable database of RefSeq genes. • 3354919 UniProtKB/Swiss-Prot • O61305 UniProtKB/TrEMBL • A8Y564 Q5LK13 Q8SYQ3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Helicase, C-terminal (IPR001650) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) RNA helicase, DEAD-box type, Q motif (IPR014014) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE44177
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0024804 DroID - A comprehensive database of gene and protein interactions. • FBgn0024804 DRSC - Results from RNAi screens. • FBgn0024804 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024804 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17023-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024804 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3354919 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3354919 modMine - Data generated by the modENCODE project. • FBgn0024804
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	BcDNA:RE44177   CG17023 (Drosophila Heterochromatin Genome Project, 2007, Ni et al., 2010.12.1, Keleman et al., 2009.8.5) Dbp80 (Schaeffer et al., 2008, Dimitri et al., 2003, Schwaiger et al., 2010, Huang et al., 2010, Roignant and Treisman, 2010, Ashton-Beaucage et al., 2010, Zhang et al., 2011, Vujatovic et al., 2012) DBP80 (Eisen et al., 1998) DmDbp80 (Schulze et al., 2006) hel-40   Hel40   HEL80 (Eisen et al., 1998) Hel80   unnamed (Eisen et al., 1997)
Name Synonym	Dead box protein 80 (Eisen et al., 1998) Helicase 40   Helicase 80 (Eisen et al., 1998)
Secondary FlyBase IDs
	FBan0017023 FBgn0020298 FBgn0024749 FBgn0042216 FBgn0047105
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 1 ) Review  ( 2 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 2 )
	Vujatovic et al., 2012, Nucleic Acids Res. 40(12): 5402--5414 Drosophila melanogaster linker histone dH1 is required for transposon silencing and to preserve genome integrity. [FBrf0218745] Zhang et al., 2011, Chromosoma 120(1): 97--108 Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. [FBrf0212898] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...