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Gene Dmel\DIP1

General Information
Symbol	Dmel\DIP1	Species	D. melanogaster
Name	DISCO Interacting Protein 1	Annotation symbol	CG17686
Feature type	protein_coding_gene	FlyBase ID	FBgn0024807
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	UbxBP1
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	20A4-20A5	Sequence location	X:21,495,823..21,501,185 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene DISCO Interacting Protein 1 is referred to in FlyBase by the symbol Dmel\DIP1 (CG17686, FBgn0024807). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: double-stranded RNA binding; protein binding; pre-miRNA binding. The biological processes in which it is involved are not known. 22 alleles are reported. The phenotypes of these alleles are annotated with: eye; antenna; wing margin bristle; head capsule; haltere; wing; arista; capitellum; wing vein. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Double-stranded RNA-binding; Double-stranded RNA-binding-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval salivary gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624215_s_at completely aligns to an exonic region common to each of the 8 FlyBase-annotated transcript isoforms of DIP1. Gene sequence location is X:21495823..21501185.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 20A4-20A5   Limits computationally determined from genome sequence between P{EP}CG1702EP1525 and P{EP}EP1465&P{EP}CG1486EP1192
Experimentally Determined Cytological Location
Cytogenetic map Notes References 20A-20A     (Robert, 1999.12.8) 20A-20A     (Mukhopadhyay, 1999.9.1) 20A-20A     (Mukhopadhyay, 1999.8.5)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\DIP1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) DIP1-RB FBtr0077371  NM_167773   3563   409 DIP1-RC FBtr0077372  NM_079929   2569   395 DIP1-RD FBtr0077373  NM_167772   2614   410 DIP1-RE FBtr0300373  NM_001169343   3833   378 DIP1-RF FBtr0300374  NM_167774   3518   394 DIP1-RG FBtr0301292  NM_001169344   3205   378 DIP1-RH FBtr0301293  NM_001169345   2476   309 DIP1-RI FBtr0301294  NM_001169346   3487   378
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein DIP1-PB   FBpp0077063   44.4   409   7.13     NP_728450   AAN09008 DIP1-PC   FBpp0077064   43.0   395   8.42     NP_524668   AAN09006 DIP1-PD   FBpp0077065   44.6   410   8.72     NP_728449   AAN09007 DIP1-PE   FBpp0289602   41.0   378   6.38     NP_001162814   ACZ95347 DIP1-PF   FBpp0289603   42.8   394   6.80     NP_728451   AAF45390 DIP1-PG   FBpp0290507   41.0   378   6.38     NP_001162815   ACZ95348 DIP1-PH   FBpp0290508   34.0   309   8.06     NP_001162816   ACZ95349 DIP1-PI   FBpp0290509   41.0   378   6.38     NP_001162817   ACZ95350
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Double-stranded RNA-binding (IPR001159) Double-stranded RNA-binding-like domain (IPR014720)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390793   AA439741   AA440213   AA540094   AA801694   AA821249   AA940836   AE014298 AAF45390   AE014298 AAN09006   AE014298 AAN09007   AE014298 AAN09008   AE014298 ACZ95347   AE014298 ACZ95348   AE014298 ACZ95349   AE014298 ACZ95350   AF175711 AAD50502   AF175713 AAD50503   AF182154 AAD56033   AF182444 AAF03831   AF182444 AAF03832   AF182444 AAF03833   AF213338 AAF25886   AF218310 AAF67101   AI114195   AI259517   AI260626   AI292905   AI293062   AI294366   AI294495   AI297480   AI297912   AI387147   AI387917   AI389075   AI402716   AI406089   AI456315   AI513026   AI513497   AJ250866 CAC17704   AJ250867 CAC17705   AJ250868 CAC17706   AJ250869 CAC17707   AJ250870 CAC17708   AJ250870 CAC17709   AJ250870 CAC17710   AJ250870 CAC17711   AY121664 AAM51991   AY217028 AAO37650   BF499063   BF501947   BF504826   BF505265   BG632658   BG632981   BG633097   BG637917   BG639148   BI166944   BI169021   BI169618   BI170390   BI172135   BI216560   BI232104   BI235319   BI239391   BI242976   BI243000   BI374166   BI374900   BI485277   BI577766   BI580619   BI610776   BI619003   BI626282   BI639145   BI639150   BP559556   BT021433 AAX33581   BT099548   BT125869   BT128746   CO182813   CO262869   CO269841   CO269998   CO270017   CO270653   CO279497   CO280929   CO285677   CO290667   CO291871   CO292448   CO295918   CO296700   CO297609   CO301029   CO303052   CO303576   CO305809   CO306637   CO308216   CO315466   CO318471   CO319383   CO325214   CO328286   CO328775   CO331590   CO333671   CO341415   CO341671   CO342442   CO345424   EC058915   EC061550   EC062681   EC066381   EC066539   EC067695   EC068301   EC072207   EC075750   EC079397   EC085319   EC087119   EC088604   EC089730   EC215027   EC215127   EC220086   EC222301   EC224102   EC224532   EC225994   EC234459   EC238809   EC243621   EC246840   EC246932   EC248891   EC249292   EC252308   EC252900   EC254034   EC258303   EC259219   EC260420   EV581940   GH984767
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MRC7 Q9TW12 Q9TW27 Q9U4F5 Q9W5S7 A4V4V2 Q9NIH3 Q86LT0 Q9GNA3 Q9GNJ2 Q9U6N4 Q9NHW9 Q9GNA6 Q9GND0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (DeSousa et al., 2003) nucleus inferred from direct assay (DeSousa et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval salivary gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1172.6 Larval Midgut    149.9 Larval Hindgut    479.8 Larval Malpighian Tubules    297.2 Larval Fat Body    324.2 Larval Salivary Gland    707.3 Larval Trachea    486.825 Larval Carcass    509.5 Adult Head    325.6 Adult Eye    594.625 Adult Brain    1183.1 Adult Thoracic-Abdominal Ganglion    1240.1 Adult Crop    498.9 Adult Midgut    187 Adult Hindgut    330.9 Adult Malpighian Tubules    302 Adult Fat Body    234.9 Adult Salivary Gland    484.6 Adult Heart    252.075 Adult VirginFemale Spermatheca    378.3 Adult InseminatedFemale Spermatheca    446.3 Adult Ovary    334.7 Adult Testis    227.5 Adult Male Accessory Gland    315.1 Adult Carcass    329.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1172.6) Larval Midgut    149.9 Larval Hindgut    479.8 Larval Malpighian Tubules    297.2 Larval Fat Body    324.2 Larval Salivary Gland  (707.3) Larval Trachea    486.825 Larval Carcass  509.5 Adult Head    325.6 Adult Eye  (594.625) Adult Brain  (1183.1) Adult Thoracic-Abdominal Ganglion  (1240.1) Adult Crop    498.9 Adult Midgut    187 Adult Hindgut    330.9 Adult Malpighian Tubules    302 Adult Fat Body    234.9 Adult Salivary Gland    484.6 Adult Heart    252.075 Adult VirginFemale Spermatheca    378.3 Adult InseminatedFemale Spermatheca    446.3 Adult Ovary    334.7 Adult Testis    227.5 Adult Male Accessory Gland    315.1 Adult Carcass    329.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1172.6) Larval Midgut    149.9 Larval Hindgut    479.8 Larval Malpighian Tubules    297.2 Larval Fat Body    324.2 Larval Salivary Gland    707.3 Larval Trachea    486.825 Larval Carcass    509.5 Adult Head    325.6 Adult Eye    594.625 Adult Brain  (1183.1) Adult Thoracic-Abdominal Ganglion  (1240.1) Adult Crop    498.9 Adult Midgut    187 Adult Hindgut    330.9 Adult Malpighian Tubules    302 Adult Fat Body    234.9 Adult Salivary Gland    484.6 Adult Heart    252.075 Adult VirginFemale Spermatheca    378.3 Adult InseminatedFemale Spermatheca    446.3 Adult Ovary    334.7 Adult Testis    227.5 Adult Male Accessory Gland    315.1 Adult Carcass    329.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1172.6 Larval Midgut    149.9 Larval Hindgut    479.8 Larval Malpighian Tubules    297.2 Larval Fat Body    324.2 Larval Salivary Gland    707.3 Larval Trachea    486.825 Larval Carcass    509.5 Adult Head    325.6 Adult Eye    594.625 Adult Brain    1183.1 Adult Thoracic-Abdominal Ganglion    1240.1 Adult Crop    498.9 Adult Midgut    187 Adult Hindgut    330.9 Adult Malpighian Tubules    302 Adult Fat Body    234.9 Adult Salivary Gland    484.6 Adult Heart    252.075 Adult VirginFemale Spermatheca    378.3 Adult InseminatedFemale Spermatheca    446.3 Adult Ovary    334.7 Adult Testis    227.5 Adult Male Accessory Gland    315.1 Adult Carcass    329.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1172.6 Larval Midgut    149.9 Larval Hindgut    479.8 Larval Malpighian Tubules    297.2 Larval Fat Body    324.2 Larval Salivary Gland    707.3 Larval Trachea    486.825 Larval Carcass    509.5 Adult Head    325.6 Adult Eye    594.625 Adult Brain    1183.1 Adult Thoracic-Abdominal Ganglion    1240.1 Adult Crop    498.9 Adult Midgut    187 Adult Hindgut    330.9 Adult Malpighian Tubules    302 Adult Fat Body    234.9 Adult Salivary Gland    484.6 Adult Heart    252.075 Adult VirginFemale Spermatheca    378.3 Adult InseminatedFemale Spermatheca    446.3 Adult Ovary    334.7 Adult Testis    227.5 Adult Male Accessory Gland    315.1 Adult Carcass    329.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1172.6) Larval Midgut    149.9 Larval Hindgut    479.8 Larval Malpighian Tubules    297.2 Larval Fat Body    324.2 Larval Salivary Gland  707.3 Larval Trachea    486.825 Larval Carcass  509.5 Adult Head    325.6 Adult Eye  594.625 Adult Brain  (1183.1) Adult Thoracic-Abdominal Ganglion  (1240.1) Adult Crop    498.9 Adult Midgut    187 Adult Hindgut    330.9 Adult Malpighian Tubules    302 Adult Fat Body    234.9 Adult Salivary Gland    484.6 Adult Heart    252.075 Adult VirginFemale Spermatheca    378.3 Adult InseminatedFemale Spermatheca    446.3 Adult Ovary    334.7 Adult Testis    227.5 Adult Male Accessory Gland    315.1 Adult Carcass    329.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1172.6 Larval Midgut    149.9 Larval Hindgut    479.8 Larval Malpighian Tubules    297.2 Larval Fat Body    324.2 Larval Salivary Gland    707.3 Larval Trachea    486.825 Larval Carcass    509.5 Adult Head    325.6 Adult Eye    594.625 Adult Brain  1183.1 Adult Thoracic-Abdominal Ganglion  1240.1 Adult Crop    498.9 Adult Midgut    187 Adult Hindgut    330.9 Adult Malpighian Tubules    302 Adult Fat Body    234.9 Adult Salivary Gland    484.6 Adult Heart    252.075 Adult VirginFemale Spermatheca    378.3 Adult InseminatedFemale Spermatheca    446.3 Adult Ovary    334.7 Adult Testis    227.5 Adult Male Accessory Gland    315.1 Adult Carcass    329.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1172.6 Larval Midgut    149.9 Larval Hindgut    479.8 Larval Malpighian Tubules    297.2 Larval Fat Body    324.2 Larval Salivary Gland    707.3 Larval Trachea    486.825 Larval Carcass    509.5 Adult Head    325.6 Adult Eye    594.625 Adult Brain    1183.1 Adult Thoracic-Abdominal Ganglion    1240.1 Adult Crop    498.9 Adult Midgut    187 Adult Hindgut    330.9 Adult Malpighian Tubules    302 Adult Fat Body    234.9 Adult Salivary Gland    484.6 Adult Heart    252.075 Adult VirginFemale Spermatheca    378.3 Adult InseminatedFemale Spermatheca    446.3 Adult Ovary    334.7 Adult Testis    227.5 Adult Male Accessory Gland    315.1 Adult Carcass    329.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    325.6   NA  Eye    594.625   NA  Brain    1183.1   1172.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1240.1   NA  Crop    498.9   149.9  Midgut    187   479.8  Hindgut    330.9   297.2  Malpighian Tubules    302   324.2  Fat Body    234.9   707.3  Salivary Gland    484.6   NA  Heart    252.075   486.825  Trachea    NA   NA  VirginFemale Spermatheca    378.3   NA  InseminatedFemale Spermatheca    446.3   NA  Ovary    334.7   NA  Testis    227.5   NA  Male Accessory Gland    315.1   509.5  Carcass    329.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    259 central nervous system, larvae L3    403 central nervous system, pupae P8    323 head, virgin 1-day female    190 head, virgin 4-day female    266 head, virgin 20-day female    158 head, mated 1-day female    255 head, mated 4-day female    213 head, mated 20-day female    150 head, mated 1-day male    351 head, mated 4-day male    385 head, mated 20-day male    350 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    160 digestive system, larvae L3 wandering    70 digestive system, 1-day adult    39 digestive system, 4-day adult    83 digestive system, 20-day adult    71 fat body, larvae L3 wandering    88 fat body, white prepupae    106 fat body, pupae P8    491 carcass, larvae L3 wandering    237 carcass, 1-day adult    91 carcass, 4-day adult    116 carcass, 20-day adult    101 ovary, virgin 4-day female    61 ovary, mated 4-day female    94 testis, mated 4-day male    85 accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (259) central nervous system, larvae L3  (403) central nervous system, pupae P8  (323) head, virgin 1-day female  (190) head, virgin 4-day female  (266) head, virgin 20-day female  (158) head, mated 1-day female  (255) head, mated 4-day female  (213) head, mated 20-day female  (150) head, mated 1-day male  (351) head, mated 4-day male  (385) head, mated 20-day male  (350) salivary gland, larvae L3 wandering  (32) salivary gland, white prepupae  (160) digestive system, larvae L3 wandering  (70) digestive system, 1-day adult  (39) digestive system, 4-day adult  (83) digestive system, 20-day adult  (71) fat body, larvae L3 wandering  (88) fat body, white prepupae  (106) fat body, pupae P8  (491) carcass, larvae L3 wandering  (237) carcass, 1-day adult  (91) carcass, 4-day adult  (116) carcass, 20-day adult  (101) ovary, virgin 4-day female  (61) ovary, mated 4-day female  (94) testis, mated 4-day male  (85) accessory gland, mated 4-day male  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (259) central nervous system, larvae L3  (403) central nervous system, pupae P8  (323) head, virgin 1-day female  (190) head, virgin 4-day female  (266) head, virgin 20-day female  (158) head, mated 1-day female  (255) head, mated 4-day female  (213) head, mated 20-day female  (150) head, mated 1-day male  (351) head, mated 4-day male  (385) head, mated 20-day male  (350) salivary gland, larvae L3 wandering    32 salivary gland, white prepupae  (160) digestive system, larvae L3 wandering    70 digestive system, 1-day adult    39 digestive system, 4-day adult    83 digestive system, 20-day adult    71 fat body, larvae L3 wandering    88 fat body, white prepupae  106 fat body, pupae P8  (491) carcass, larvae L3 wandering  (237) carcass, 1-day adult    91 carcass, 4-day adult  (116) carcass, 20-day adult  101 ovary, virgin 4-day female    61 ovary, mated 4-day female    94 testis, mated 4-day male    85 accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    259 central nervous system, larvae L3    403 central nervous system, pupae P8    323 head, virgin 1-day female    190 head, virgin 4-day female    266 head, virgin 20-day female    158 head, mated 1-day female    255 head, mated 4-day female    213 head, mated 20-day female    150 head, mated 1-day male    351 head, mated 4-day male    385 head, mated 20-day male    350 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    160 digestive system, larvae L3 wandering    70 digestive system, 1-day adult    39 digestive system, 4-day adult    83 digestive system, 20-day adult    71 fat body, larvae L3 wandering    88 fat body, white prepupae    106 fat body, pupae P8    491 carcass, larvae L3 wandering    237 carcass, 1-day adult    91 carcass, 4-day adult    116 carcass, 20-day adult    101 ovary, virgin 4-day female    61 ovary, mated 4-day female    94 testis, mated 4-day male    85 accessory gland, mated 4-day male    52 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    259 central nervous system, larvae L3    403 central nervous system, pupae P8    323 head, virgin 1-day female    190 head, virgin 4-day female    266 head, virgin 20-day female    158 head, mated 1-day female    255 head, mated 4-day female    213 head, mated 20-day female    150 head, mated 1-day male    351 head, mated 4-day male    385 head, mated 20-day male    350 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    160 digestive system, larvae L3 wandering    70 digestive system, 1-day adult    39 digestive system, 4-day adult    83 digestive system, 20-day adult    71 fat body, larvae L3 wandering    88 fat body, white prepupae    106 fat body, pupae P8    491 carcass, larvae L3 wandering    237 carcass, 1-day adult    91 carcass, 4-day adult    116 carcass, 20-day adult    101 ovary, virgin 4-day female    61 ovary, mated 4-day female    94 testis, mated 4-day male    85 accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (259) central nervous system, larvae L3  (403) central nervous system, pupae P8  (323) head, virgin 1-day female  (190) head, virgin 4-day female  (266) head, virgin 20-day female  (158) head, mated 1-day female  (255) head, mated 4-day female  (213) head, mated 20-day female  (150) head, mated 1-day male  (351) head, mated 4-day male  (385) head, mated 20-day male  (350) salivary gland, larvae L3 wandering  32 salivary gland, white prepupae  (160) digestive system, larvae L3 wandering  (70) digestive system, 1-day adult  (39) digestive system, 4-day adult  (83) digestive system, 20-day adult  (71) fat body, larvae L3 wandering  (88) fat body, white prepupae  (106) fat body, pupae P8  (491) carcass, larvae L3 wandering  (237) carcass, 1-day adult  (91) carcass, 4-day adult  (116) carcass, 20-day adult  (101) ovary, virgin 4-day female  (61) ovary, mated 4-day female  (94) testis, mated 4-day male  (85) accessory gland, mated 4-day male  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (259) central nervous system, larvae L3  (403) central nervous system, pupae P8  (323) head, virgin 1-day female  (190) head, virgin 4-day female  (266) head, virgin 20-day female  (158) head, mated 1-day female  (255) head, mated 4-day female  (213) head, mated 20-day female  (150) head, mated 1-day male  (351) head, mated 4-day male  (385) head, mated 20-day male  (350) salivary gland, larvae L3 wandering    32 salivary gland, white prepupae  (160) digestive system, larvae L3 wandering    70 digestive system, 1-day adult    39 digestive system, 4-day adult    83 digestive system, 20-day adult    71 fat body, larvae L3 wandering    88 fat body, white prepupae  106 fat body, pupae P8  (491) carcass, larvae L3 wandering  (237) carcass, 1-day adult    91 carcass, 4-day adult  116 carcass, 20-day adult  101 ovary, virgin 4-day female    61 ovary, mated 4-day female    94 testis, mated 4-day male    85 accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    259 central nervous system, larvae L3    403 central nervous system, pupae P8    323 head, virgin 1-day female    190 head, virgin 4-day female    266 head, virgin 20-day female    158 head, mated 1-day female    255 head, mated 4-day female    213 head, mated 20-day female    150 head, mated 1-day male    351 head, mated 4-day male    385 head, mated 20-day male    350 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    160 digestive system, larvae L3 wandering    70 digestive system, 1-day adult    39 digestive system, 4-day adult    83 digestive system, 20-day adult    71 fat body, larvae L3 wandering    88 fat body, white prepupae    106 fat body, pupae P8    491 carcass, larvae L3 wandering    237 carcass, 1-day adult    91 carcass, 4-day adult    116 carcass, 20-day adult    101 ovary, virgin 4-day female    61 ovary, mated 4-day female    94 testis, mated 4-day male    85 accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    42 embryo 04-06hr    54 embryo 06-08hr    54 embryo 08-10hr    49 embryo 10-12hr    27 embryo 12-14hr    48 embryo 14-16hr    55 embryo 16-18hr    48 embryo 18-20hr    37 embryo 20-22hr    33 embryo 22-24hr    33 larva L1    39 larva L2    27 larva L3 12hr old    21 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    55 white prepupae new    58 white prepupae 12hr    68 white prepupae 24hr    93 pupae 2d postWPP    102 pupae 3d postWPP    54 pupae 4d postWPP    33 adult male 01day    34 adult male 05day    57 adult male 30day    47 adult female 01day    32 adult female 05day    26 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr  (42) embryo 04-06hr  (54) embryo 06-08hr  (54) embryo 08-10hr  (49) embryo 10-12hr  (27) embryo 12-14hr  (48) embryo 14-16hr  (55) embryo 16-18hr  (48) embryo 18-20hr  (37) embryo 20-22hr  (33) embryo 22-24hr  (33) larva L1  (39) larva L2  (27) larva L3 12hr old    21 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6  (40) larva L3 puffstage 7-9  (55) white prepupae new  (58) white prepupae 12hr  (68) white prepupae 24hr  (93) pupae 2d postWPP  (102) pupae 3d postWPP  (54) pupae 4d postWPP  (33) adult male 01day  (34) adult male 05day  (57) adult male 30day  (47) adult female 01day  (32) adult female 05day  26 adult female 30day  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    42 embryo 04-06hr    54 embryo 06-08hr    54 embryo 08-10hr    49 embryo 10-12hr    27 embryo 12-14hr    48 embryo 14-16hr    55 embryo 16-18hr    48 embryo 18-20hr    37 embryo 20-22hr    33 embryo 22-24hr    33 larva L1    39 larva L2    27 larva L3 12hr old    21 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    55 white prepupae new    58 white prepupae 12hr    68 white prepupae 24hr    93 pupae 2d postWPP  102 pupae 3d postWPP    54 pupae 4d postWPP    33 adult male 01day    34 adult male 05day    57 adult male 30day    47 adult female 01day    32 adult female 05day    26 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    42 embryo 04-06hr    54 embryo 06-08hr    54 embryo 08-10hr    49 embryo 10-12hr    27 embryo 12-14hr    48 embryo 14-16hr    55 embryo 16-18hr    48 embryo 18-20hr    37 embryo 20-22hr    33 embryo 22-24hr    33 larva L1    39 larva L2    27 larva L3 12hr old    21 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    55 white prepupae new    58 white prepupae 12hr    68 white prepupae 24hr    93 pupae 2d postWPP    102 pupae 3d postWPP    54 pupae 4d postWPP    33 adult male 01day    34 adult male 05day    57 adult male 30day    47 adult female 01day    32 adult female 05day    26 adult female 30day    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    42 embryo 04-06hr    54 embryo 06-08hr    54 embryo 08-10hr    49 embryo 10-12hr    27 embryo 12-14hr    48 embryo 14-16hr    55 embryo 16-18hr    48 embryo 18-20hr    37 embryo 20-22hr    33 embryo 22-24hr    33 larva L1    39 larva L2    27 larva L3 12hr old    21 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    55 white prepupae new    58 white prepupae 12hr    68 white prepupae 24hr    93 pupae 2d postWPP    102 pupae 3d postWPP    54 pupae 4d postWPP    33 adult male 01day    34 adult male 05day    57 adult male 30day    47 adult female 01day    32 adult female 05day    26 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr  (42) embryo 04-06hr  (54) embryo 06-08hr  (54) embryo 08-10hr  (49) embryo 10-12hr  27 embryo 12-14hr  (48) embryo 14-16hr  (55) embryo 16-18hr  (48) embryo 18-20hr  (37) embryo 20-22hr  (33) embryo 22-24hr  (33) larva L1  (39) larva L2  27 larva L3 12hr old    21 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6  (40) larva L3 puffstage 7-9  (55) white prepupae new  (58) white prepupae 12hr  (68) white prepupae 24hr  (93) pupae 2d postWPP  (102) pupae 3d postWPP  (54) pupae 4d postWPP  (33) adult male 01day  (34) adult male 05day  (57) adult male 30day  (47) adult female 01day  32 adult female 05day  26 adult female 30day  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    42 embryo 04-06hr    54 embryo 06-08hr    54 embryo 08-10hr    49 embryo 10-12hr    27 embryo 12-14hr    48 embryo 14-16hr    55 embryo 16-18hr    48 embryo 18-20hr    37 embryo 20-22hr    33 embryo 22-24hr    33 larva L1    39 larva L2    27 larva L3 12hr old    21 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    55 white prepupae new    58 white prepupae 12hr    68 white prepupae 24hr    93 pupae 2d postWPP  102 pupae 3d postWPP    54 pupae 4d postWPP    33 adult male 01day    34 adult male 05day    57 adult male 30day    47 adult female 01day    32 adult female 05day    26 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    42 embryo 04-06hr    54 embryo 06-08hr    54 embryo 08-10hr    49 embryo 10-12hr    27 embryo 12-14hr    48 embryo 14-16hr    55 embryo 16-18hr    48 embryo 18-20hr    37 embryo 20-22hr    33 embryo 22-24hr    33 larva L1    39 larva L2    27 larva L3 12hr old    21 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    55 white prepupae new    58 white prepupae 12hr    68 white prepupae 24hr    93 pupae 2d postWPP    102 pupae 3d postWPP    54 pupae 4d postWPP    33 adult male 01day    34 adult male 05day    57 adult male 30day    47 adult female 01day    32 adult female 05day    26 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    51 Schneider line 2 Sg4    42 embryonic 1182-4H    225 embryonic GM2    92 embryonic Kc167    46 embryonic S1    129 embryonic S3    59 leg disc CME L1    97 wing disc CME-W2    50 wing disc ML-DmD8    127 wing disc ML-DmD9    408 wing disc ML-DmD16-c3    121 wing disc ML-DmD21    51 wing disc ML-DmD32    112 haltere disc ML-DmD17-c3    144 eye-antennal disc ML-DmD11    123 antennal disc ML-DmD20-c5    55 mixed discs ML-DmD4-c1    80 CNS ML-DmBG1-c1    179 CNS ML-DmBG2-c2    103 tumorous blood cells mbn2    45 ovary fGS/OSS    550 ovary OSC    404 ovary OSS    194 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (51) Schneider line 2 Sg4  (42) embryonic 1182-4H  (225) embryonic GM2  (92) embryonic Kc167  (46) embryonic S1  (129) embryonic S3  (59) leg disc CME L1  (97) wing disc CME-W2  (50) wing disc ML-DmD8  (127) wing disc ML-DmD9  (408) wing disc ML-DmD16-c3  (121) wing disc ML-DmD21  (51) wing disc ML-DmD32  (112) haltere disc ML-DmD17-c3  (144) eye-antennal disc ML-DmD11  (123) antennal disc ML-DmD20-c5  (55) mixed discs ML-DmD4-c1  (80) CNS ML-DmBG1-c1  (179) CNS ML-DmBG2-c2  (103) tumorous blood cells mbn2  (45) ovary fGS/OSS  (550) ovary OSC  (404) ovary OSS  (194) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    51 Schneider line 2 Sg4    42 embryonic 1182-4H  (225) embryonic GM2    92 embryonic Kc167    46 embryonic S1  (129) embryonic S3    59 leg disc CME L1    97 wing disc CME-W2    50 wing disc ML-DmD8  (127) wing disc ML-DmD9  (408) wing disc ML-DmD16-c3  (121) wing disc ML-DmD21    51 wing disc ML-DmD32  (112) haltere disc ML-DmD17-c3  (144) eye-antennal disc ML-DmD11  (123) antennal disc ML-DmD20-c5    55 mixed discs ML-DmD4-c1    80 CNS ML-DmBG1-c1  (179) CNS ML-DmBG2-c2  103 tumorous blood cells mbn2    45 ovary fGS/OSS  (550) ovary OSC  (404) ovary OSS  (194) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    51 Schneider line 2 Sg4    42 embryonic 1182-4H    225 embryonic GM2    92 embryonic Kc167    46 embryonic S1    129 embryonic S3    59 leg disc CME L1    97 wing disc CME-W2    50 wing disc ML-DmD8    127 wing disc ML-DmD9    408 wing disc ML-DmD16-c3    121 wing disc ML-DmD21    51 wing disc ML-DmD32    112 haltere disc ML-DmD17-c3    144 eye-antennal disc ML-DmD11    123 antennal disc ML-DmD20-c5    55 mixed discs ML-DmD4-c1    80 CNS ML-DmBG1-c1    179 CNS ML-DmBG2-c2    103 tumorous blood cells mbn2    45 ovary fGS/OSS    550 ovary OSC    404 ovary OSS    194 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    51 Schneider line 2 Sg4    42 embryonic 1182-4H    225 embryonic GM2    92 embryonic Kc167    46 embryonic S1    129 embryonic S3    59 leg disc CME L1    97 wing disc CME-W2    50 wing disc ML-DmD8    127 wing disc ML-DmD9    408 wing disc ML-DmD16-c3    121 wing disc ML-DmD21    51 wing disc ML-DmD32    112 haltere disc ML-DmD17-c3    144 eye-antennal disc ML-DmD11    123 antennal disc ML-DmD20-c5    55 mixed discs ML-DmD4-c1    80 CNS ML-DmBG1-c1    179 CNS ML-DmBG2-c2    103 tumorous blood cells mbn2    45 ovary fGS/OSS    550 ovary OSC    404 ovary OSS    194 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (51) Schneider line 2 Sg4  (42) embryonic 1182-4H  (225) embryonic GM2  (92) embryonic Kc167  (46) embryonic S1  (129) embryonic S3  (59) leg disc CME L1  (97) wing disc CME-W2  (50) wing disc ML-DmD8  (127) wing disc ML-DmD9  (408) wing disc ML-DmD16-c3  (121) wing disc ML-DmD21  (51) wing disc ML-DmD32  (112) haltere disc ML-DmD17-c3  (144) eye-antennal disc ML-DmD11  (123) antennal disc ML-DmD20-c5  (55) mixed discs ML-DmD4-c1  (80) CNS ML-DmBG1-c1  (179) CNS ML-DmBG2-c2  (103) tumorous blood cells mbn2  (45) ovary fGS/OSS  (550) ovary OSC  (404) ovary OSS  (194) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    51 Schneider line 2 Sg4    42 embryonic 1182-4H  (225) embryonic GM2    92 embryonic Kc167    46 embryonic S1  129 embryonic S3    59 leg disc CME L1    97 wing disc CME-W2    50 wing disc ML-DmD8  127 wing disc ML-DmD9  (408) wing disc ML-DmD16-c3  121 wing disc ML-DmD21    51 wing disc ML-DmD32  112 haltere disc ML-DmD17-c3  (144) eye-antennal disc ML-DmD11  123 antennal disc ML-DmD20-c5    55 mixed discs ML-DmD4-c1    80 CNS ML-DmBG1-c1  (179) CNS ML-DmBG2-c2  103 tumorous blood cells mbn2    45 ovary fGS/OSS  (550) ovary OSC  (404) ovary OSS  (194) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    51 Schneider line 2 Sg4    42 embryonic 1182-4H    225 embryonic GM2    92 embryonic Kc167    46 embryonic S1    129 embryonic S3    59 leg disc CME L1    97 wing disc CME-W2    50 wing disc ML-DmD8    127 wing disc ML-DmD9    408 wing disc ML-DmD16-c3    121 wing disc ML-DmD21    51 wing disc ML-DmD32    112 haltere disc ML-DmD17-c3    144 eye-antennal disc ML-DmD11    123 antennal disc ML-DmD20-c5    55 mixed discs ML-DmD4-c1    80 CNS ML-DmBG1-c1    179 CNS ML-DmBG2-c2    103 tumorous blood cells mbn2    45 ovary fGS/OSS    550 ovary OSC    404 ovary OSS    194 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    249 cold shock, 4-day adult    220 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    80 Cadmium 100 mM 48 hrs, 4-day adult    119 Copper 0.5 mM 12 hrs, larvae L3    70 Copper 15 mM 48 hrs, 4-day adult    54 Zinc 5 mM 12 hrs, larvae L3    132 Zinc 4.5 mM 48 hrs, 4-day adult    176 Ethanol 2.5% 3 hrs, larvae L3    82 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    38 Caffeine 1.5 mg/ml 4 hrs, larvae L3    45 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    112 Caffeine 25 mg/ml 48 hrs, 4-day adult    190 Paraquat 5 mM 48 hrs, 4-day adult    112 Paraquat 10 mM 48 hrs, 4-day adult    114 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (249) cold shock, 4-day adult  (220) heat shock, 4-day adult  (53) Cadmium 50 mM 6 hrs, larvae L3  26 Cadmium 50 mM 12 hrs, larvae L3  (50) Cadmium 50 mM 48 hrs, 4-day adult  (80) Cadmium 100 mM 48 hrs, 4-day adult  (119) Copper 0.5 mM 12 hrs, larvae L3  (70) Copper 15 mM 48 hrs, 4-day adult  (54) Zinc 5 mM 12 hrs, larvae L3  (132) Zinc 4.5 mM 48 hrs, 4-day adult  (176) Ethanol 2.5% 3 hrs, larvae L3  (82) Ethanol 5% 3 hrs, larvae L3  (33) Ethanol 10% 3 hrs, larvae L3  (38) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (45) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (112) Caffeine 25 mg/ml 48 hrs, 4-day adult  (190) Paraquat 5 mM 48 hrs, 4-day adult  (112) Paraquat 10 mM 48 hrs, 4-day adult  (114) Rotenone 2 μg 12 hrs, larvae L3  (31) Rotenone 8 μg 12 hrs, larvae L3  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (249) cold shock, 4-day adult  (220) heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    80 Cadmium 100 mM 48 hrs, 4-day adult  (119) Copper 0.5 mM 12 hrs, larvae L3    70 Copper 15 mM 48 hrs, 4-day adult    54 Zinc 5 mM 12 hrs, larvae L3  (132) Zinc 4.5 mM 48 hrs, 4-day adult  (176) Ethanol 2.5% 3 hrs, larvae L3    82 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    38 Caffeine 1.5 mg/ml 4 hrs, larvae L3    45 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (112) Caffeine 25 mg/ml 48 hrs, 4-day adult  (190) Paraquat 5 mM 48 hrs, 4-day adult  (112) Paraquat 10 mM 48 hrs, 4-day adult  (114) Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    249 cold shock, 4-day adult    220 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    80 Cadmium 100 mM 48 hrs, 4-day adult    119 Copper 0.5 mM 12 hrs, larvae L3    70 Copper 15 mM 48 hrs, 4-day adult    54 Zinc 5 mM 12 hrs, larvae L3    132 Zinc 4.5 mM 48 hrs, 4-day adult    176 Ethanol 2.5% 3 hrs, larvae L3    82 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    38 Caffeine 1.5 mg/ml 4 hrs, larvae L3    45 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    112 Caffeine 25 mg/ml 48 hrs, 4-day adult    190 Paraquat 5 mM 48 hrs, 4-day adult    112 Paraquat 10 mM 48 hrs, 4-day adult    114 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    249 cold shock, 4-day adult    220 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    80 Cadmium 100 mM 48 hrs, 4-day adult    119 Copper 0.5 mM 12 hrs, larvae L3    70 Copper 15 mM 48 hrs, 4-day adult    54 Zinc 5 mM 12 hrs, larvae L3    132 Zinc 4.5 mM 48 hrs, 4-day adult    176 Ethanol 2.5% 3 hrs, larvae L3    82 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    38 Caffeine 1.5 mg/ml 4 hrs, larvae L3    45 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    112 Caffeine 25 mg/ml 48 hrs, 4-day adult    190 Paraquat 5 mM 48 hrs, 4-day adult    112 Paraquat 10 mM 48 hrs, 4-day adult    114 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (249) cold shock, 4-day adult  (220) heat shock, 4-day adult  (53) Cadmium 50 mM 6 hrs, larvae L3  26 Cadmium 50 mM 12 hrs, larvae L3  (50) Cadmium 50 mM 48 hrs, 4-day adult  (80) Cadmium 100 mM 48 hrs, 4-day adult  (119) Copper 0.5 mM 12 hrs, larvae L3  (70) Copper 15 mM 48 hrs, 4-day adult  (54) Zinc 5 mM 12 hrs, larvae L3  (132) Zinc 4.5 mM 48 hrs, 4-day adult  (176) Ethanol 2.5% 3 hrs, larvae L3  (82) Ethanol 5% 3 hrs, larvae L3  (33) Ethanol 10% 3 hrs, larvae L3  (38) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (45) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (112) Caffeine 25 mg/ml 48 hrs, 4-day adult  (190) Paraquat 5 mM 48 hrs, 4-day adult  (112) Paraquat 10 mM 48 hrs, 4-day adult  (114) Rotenone 2 μg 12 hrs, larvae L3  31 Rotenone 8 μg 12 hrs, larvae L3  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (249) cold shock, 4-day adult  (220) heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    80 Cadmium 100 mM 48 hrs, 4-day adult  119 Copper 0.5 mM 12 hrs, larvae L3    70 Copper 15 mM 48 hrs, 4-day adult    54 Zinc 5 mM 12 hrs, larvae L3  132 Zinc 4.5 mM 48 hrs, 4-day adult  (176) Ethanol 2.5% 3 hrs, larvae L3    82 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    38 Caffeine 1.5 mg/ml 4 hrs, larvae L3    45 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  112 Caffeine 25 mg/ml 48 hrs, 4-day adult  (190) Paraquat 5 mM 48 hrs, 4-day adult  112 Paraquat 10 mM 48 hrs, 4-day adult  114 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    249 cold shock, 4-day adult    220 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    80 Cadmium 100 mM 48 hrs, 4-day adult    119 Copper 0.5 mM 12 hrs, larvae L3    70 Copper 15 mM 48 hrs, 4-day adult    54 Zinc 5 mM 12 hrs, larvae L3    132 Zinc 4.5 mM 48 hrs, 4-day adult    176 Ethanol 2.5% 3 hrs, larvae L3    82 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    38 Caffeine 1.5 mg/ml 4 hrs, larvae L3    45 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    112 Caffeine 25 mg/ml 48 hrs, 4-day adult    190 Paraquat 5 mM 48 hrs, 4-day adult    112 Paraquat 10 mM 48 hrs, 4-day adult    114 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_25 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • RE10847 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024807 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17686-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4ey.PH DIP1b.Scer\UAS DIP1c.Scer\UAS lethal, with Scer\GAL4hs.PB DIP1b.Scer\UAS DIP1c.Scer\UAS viable, with Scer\GAL4pnr-MD237 DIP1GD15889 Sterility Allele female fertile DIP1EY02625 fertile DIP1EY4R DIP1G1261 DIP1GE89R Other Phenotypes Allele decreased cell number, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS visible, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS visible, with Scer\GAL4ey.PH DIP1b.Scer\UAS Phenotype manifest in Allele antenna, with Scer\GAL4ey.PH DIP1c.Scer\UAS antenna | ectopic, with Scer\GAL4ey.PH DIP1b.Scer\UAS arista, with Scer\GAL4ey.PH DIP1c.Scer\UAS capitellum, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS chaeta | ectopic, with Scer\GAL4ey.PH DIP1b.Scer\UAS eye, with Scer\GAL4ey.PH DIP1b.Scer\UAS DIP1c.Scer\UAS haltere, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS head capsule, with Scer\GAL4ey.PH DIP1b.Scer\UAS head capsule | ectopic, with Scer\GAL4ey.PH DIP1c.Scer\UAS wing, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS wing margin bristle, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS wing vein, with Scer\GAL4Bx-MS1096 DIP1c.Scer\UAS
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of DIP1 Class Mutagen Stocks Known lesion DIP1EY02625 P-element activity 1 -- DIP1MB00541 1 -- DIP1EY18P Delta2-3 0 Yes DIP1EY4R Delta2-3 0 Yes DIP1G1261 0 Yes DIP1GE89R P-element activity 0 Yes DIP1IdSS natural population 0 Yes
Alleles Carried on Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Allele of DIP1 Class Mutagen Stocks Known lesion DIP1GD15889 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes DIP1GL00110 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DIP1GL00242 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DIP1KK105102 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DIP1b.hs in vitro construct - regulatory fusion 0 Yes DIP1b.Scer\UAS in vitro construct - regulatory fusion 0 Yes DIP1c.hs in vitro construct - regulatory fusion 0 Yes DIP1c.Scer\UAS in vitro construct - regulatory fusion 0 Yes DIP1cos7a in vitro construct - genomic fragment 0 Yes DIP1dsRBDΔ1.b.Scer\UAS in vitro construct - deletion 0 Yes DIP1dsRBDΔ1.c.Scer\UAS in vitro construct - deletion 0 Yes DIP1dsRBDΔ2.b.Scer\UAS in vitro construct - deletion 0 Yes DIP1dsRBDΔ2.c.Scer\UAS in vitro construct - deletion 0 Yes DIP1t8 in vitro construct - genomic fragment 0 Yes DIP1tCH322-146O15 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6255 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD15889} NA P{KK105102} NA P{TRiP.GL00110} NA P{TRiP.GL00242} NA P{UAS-DIP1.b.dsRBDΔ1} NA P{UAS-DIP1.b.dsRBDΔ2} NA P{UAS-DIP1.b} NA P{UAS-DIP1.c.dsRBDΔ1} NA P{UAS-DIP1.c.dsRBDΔ2} NA P{UAS-DIP1.c} NA heat-shock construct P{hs-DIP1-b} NA P{hs-DIP1-c} NA characterization construct P{DIP1cos7a} NA P{DIP1t8} NA PBac{CH322-146O15} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}DIP1G1261 NA P{EPgy2}DIP1EY02625 NA insertion of enhancer trap binary system Mi{ET1}DIP1MB00541 No miscellaneous insertions HB{}DIP1IdSS NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
double-stranded RNA binding inferred from direct assay (Bondos et al., 2004, Catanese and Matthews, 2010) pre-miRNA binding inferred from direct assay (Catanese and Matthews, 2010) protein binding inferred from physical interaction with Ubx (Bondos et al., 2004)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (DeSousa et al., 2003) nucleus inferred from direct assay (DeSousa et al., 2003)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
chromatin binding non-traceable author statement (Krauss, 1999.11.8) double-stranded RNA binding inferred from sequence or structural similarity (Mukhopadhyay et al., 1998, Lasko, 2000) non-traceable author statement (Mukhopadhyay, 1999.8.5, Tan, 2003.1.10)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
chromatin non-traceable author statement (Krauss, 1999.11.8)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions DIP1 allele Gene References DIP1c.Scer\UAS Ubx (Bondos et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68755 DroID - A comprehensive database of gene and protein interactions. • FBgn0024807 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43981
Orthologs
OrthoDB Orthologs (52) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6P8G44 Dipteran inclusive ortholog search EOG6G4H0M Insect inclusive ortholog search EOG6XD2N5 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6P8G44)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\DIP1     Drosophila simulans   Dsim\GD24430     Drosophila simulans   Dsim\GD15489     Drosophila simulans   Dsim\GD24670 Y   Drosophila sechellia   Dsec\GM19637     Drosophila sechellia   Dsec\GM13531 Y   Drosophila sechellia   Dsec\GM13533     Drosophila sechellia   Dsec\GM13532     Drosophila sechellia   Dsec\GM19631     Drosophila sechellia   Dsec\GM19640     Drosophila sechellia   Dsec\GM19636     Drosophila sechellia   Dsec\GM13527     Drosophila sechellia   Dsec\GM16196     Drosophila sechellia   Dsec\GM24510     Drosophila sechellia   Dsec\GM19639     Drosophila sechellia   Dsec\GM19632     Drosophila sechellia   Dsec\GM16197     Drosophila erecta   Dere\GG17525 Y   Drosophila yakuba   Dyak\GE15285 Y   Drosophila ananassae   Dana\GF10760     Drosophila pseudoobscura pseudoobscura   Dpse\GA14612 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26778     Drosophila persimilis   Dper\GL13431 Y   Drosophila persimilis   Dper\GL27226     Drosophila willistoni   Dwil\GK25242 Y   Drosophila virilis   Dvir\GJ10989     Drosophila virilis   Dvir\GJ19010 Y   Drosophila mojavensis   Dmoj\GI14602 Y   Drosophila grimshawi   Dgri\GH17808 Y
Orthologs in non-Drosophila Dipterans (EOG6G4H0M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012964 Y Anopheles gambiae Malaria mosquito  Agam\AGAP004281 Y Anopheles gambiae Malaria mosquito  Agam\AGAP001028 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014041 Y
Orthologs in non-Dipteran Insects (EOG6XD2N5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB42448 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG021313 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004072 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21598 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22905 Y Atta cephalotes Leafcutter ant  Acep\ACEP20219 Y Atta cephalotes Leafcutter ant  Acep\ACEP16191 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18666 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18271 Y Linepithema humile Argentine ant  Lhum\LH19360 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB25038 Y Solenopsis invicta Red fire ant  Sinv\SINV25551 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009785 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI51691 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI21037 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI064116 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI35121 Y Bombyx mori Silkmoth  Bmor\BGIBMGA009922 Y Tribolium castaneum Red flour beetle  Tcas\TC015220 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24670 Drosophila sechellia Dsec\GM13531 Drosophila erecta Dere\GG17525 Drosophila yakuba Dyak\GE15285 Drosophila ananassae Dana\GF20931 Drosophila pseudoobscura pseudoobscura Dpse\GA14612 Drosophila persimilis Dper\GL13431 Drosophila willistoni Dwil\GK25242 Drosophila virilis Dvir\GJ19010 Drosophila mojavensis Dmoj\GI14602 Drosophila grimshawi Dgri\GH17808
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	22833 w1118 Mi{ET1}DIP1MB00541 15577 y1 w67c23 P{EPgy2}DIP1EY02625 35226 y1 sc* v1; P{TRiP.GL00110}attP2 35333 y1 sc* v1; P{TRiP.GL00242}attP2
VDRC	v108186 P{KK105102}VIE-260B v50206 w1118; P{GD15889}v50206 v50207 w1118; P{GD15889}v50207
Genomic Clones ( 2 )
	BACR22O16 BACR38K14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 120 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH20159 LD08867 LD14381 RE10847 SD25235
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT06857 AT07455 AT13550 AT17539 GH10918 GH11943 GH15935 GH16142 GH18616 GH21996 GH26266 GH26615 GM03322 HL07992 LD08769 LD19452 LD23092 LD36232 LP02946 LP04558 LP07724 LP07878 LP11783 LP12356 RE07195 RE09976 RE11817 RE14404 RE23740 RE28121 RE31150 RE35869 RE40487 RE40524 RE61689 RE62588 RE68577 RE71506 RE74835 RH16562 RH49960 RH66852 SD21610 SD21620
Other clones	1756 20709 35357 41997 53053 54836 57013 67580 70623 71864 77715 79838 81279 120253 121943 146508 153630 156960 158536 161938 167122.2 167455 214341.66 214407.66 214439.79 214531.61 214537.77 214577.45 273551 282109 CK01.96A.D11 CK01.115D.C4 CK01.126D.B4 Dmel_dig_011391_0590_2965 EC24067 EK074714 EK086608 EK096047 EK097101 EK097138 EK099709 EK134757 EK155512 EK169841 EK170164 EK179927 EK195841 EK198551 EK200215 EK212244 EK214656 EK239811 EK242136 EK249459 EK251638 EK257023 EK261551 EK272252 EK277847 EK291406 EK300617 EK307638 EP08915 EP12415 EP12927 EP14925 EP22028 FGM321F02 GH17590 LD45242 RP004151099
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024807 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43981
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: UbxBP1 CG17686 (FlyBase, 1996-)
Source for database merge of
Additional comments	"DIP1" does not correspond to the "flam" locus. (Mevel-Ninio et al., 2007) Source for identity of UbxBP1 CG17686 was sequence comparison (date:000504). (FlyBase, 1996-)
Other Comments
	Ternary complex formation can occur between UbxIb protein, DIP1-c protein and Ubx target DNA. (Bondos et al., 2004) Identification: Yeast two hybrid screen for proteins that interact with disco. (Mukhopadhyay et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079929 NM_167772 NM_167773 NM_167774 NM_001169343 NM_001169344 NM_001169345 NM_001169346 RefSeq (Proteins) • NP_524668 NP_728449 NP_728450 NP_728451 NP_001162814 NP_001162815 NP_001162816 NP_001162817 DDBJ / EMBL / GenBank • AA390793 AA439741 AA440213 AA540094 AA940836 AAD50502 AAD50503 AAD56033 AAF03831 AAF03832 AAF03833 AAF25886 AAF45390 AAF67101 AAM51991 AAN09006 AAN09007 AAN09008 AAO37650 AAX33581 ACZ95347 ACZ95348 ACZ95349 ACZ95350 ACZ95351 AF175711 AF175713 AF182154 AF182444 AF213338 AF218310 AI259517 AI292905 AI293062 AI294366 AI294495 AI297480 AI297912 AI387147 AI387917 AI389075 AI402716 AI406089 AI456315 AI513026 AI513497 AJ250866 AJ250867 AJ250868 AJ250869 AJ250870 AY121664 AY217028 BG632981 BG633097 BG639148 BI169618 BT021433 CAC17704 CAC17705 CAC17706 CAC17707 CAC17708 CAC17709 CAC17710 CAC17711 Entrez Gene - A searchable database of RefSeq genes. • 43981 UniProtKB/TrEMBL • A4V4V2 Q8MRC7 Q9GNA3 Q9GNA6 Q9GND0 Q9GNJ2 Q9NHW9 Q9NIH3 Q9TW12 Q9TW27 Q9U4F5 Q9U6N4 Q9W5S7 Q86LT0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Double-stranded RNA-binding (IPR001159) Double-stranded RNA-binding-like domain (IPR014720) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE10847
Linkouts
	BioGRID - A database of protein and genetic interactions • 68755 DroID - A comprehensive database of gene and protein interactions. • FBgn0024807 DRSC - Results from RNAi screens. • FBgn0024807 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024807 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17686-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024807 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43981 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43981 modMine - Data generated by the modENCODE project. • FBgn0024807
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG17686 (Mount, 2001.8.14, Keleman et al., 2009.8.5, Nishida et al., 2007, Ni et al., 2011.7.19) clot 2020 (Robert et al., 2001) clot 10495 (Robert et al., 2001) dip1 (De Sousa et al., 2000, Robert, 1999.12.8, Robert, 1999.9.2, Mukhopadhyay, 1999.9.1, Mukhopadhyay, 1999.8.5, Mukhopadhyay, 1999.8.5, ) DIP1 (Mevel-Ninio et al., 2007, Brennecke et al., 2007, Immonen and Ritchie, 2012, Venken et al., 2009, Bergman et al., 2006, Catanese and Matthews, 2010, Nefedova et al., 2007, Potapova et al., 2009, Usov et al., 2011) dip1a (Robert et al., 2001) klt (Krauss et al., 2001) TO34 (Robert et al., 2001) TO67 (Robert et al., 2001) UbxBP1 (Catanese and Matthews, 2002, Robert et al., 2001, Tan, 1999.12.21, ) unnamed (Mukhopadhyay et al., 1998)
Name Synonym	DISCO Interacting Protein 1 (Mukhopadhyay et al., 1998) klett (Krauss et al., 2001, Robert et al., 2001, Krauss, 1999.11.8) Ultrabithorax binding protein 1 (Tan, 1999.12.21)
Secondary FlyBase IDs
References ( 50 )
Generate a list of	All references relating to this gene ( 50 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 8 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Immonen and Ritchie, 2012, Proc. Biol. Sci. 279(1732): 1359--1365 The genomic response to courtship song stimulation in female Drosophila melanogaster. [FBrf0217554] Catanese and Matthews, 2011, Biochem. Biophys. Res. Commun. 414(3): 506--511 Disconnected Interacting Protein 1 binds with high affinity to pre-tRNA and ADAT. [FBrf0216523] Usov et al., 2011, Russ. J. Genet. 47(4): 417--424 Analysis of the chromocenter DNA composition in polytene chromosomes of Drosophila orena ovarian nurse cells. [FBrf0218794] Usov et al., 2011, Genetika, Moscow 47(4): 475--483 [Analysis of the chromocenter DNA composition in polytene chromosomes of Drosophila orena ovarian nurse cells]. [FBrf0213952] Show all research papers ...