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Gene Dmel\Crk

General Information
Symbol	Dmel\Crk	Species	D. melanogaster
Name	Crk	Annotation symbol	CG1587
Feature type	protein_coding_gene	FlyBase ID	FBgn0024811
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	dCrk, D-Crk
Genomic Location
Chromosome (arm)	4	Recombination map
Cytogenetic map	102A8-102A8	Sequence location	4:230,850..233,791 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Crk is referred to in FlyBase by the symbol Dmel\Crk (CG1587, FBgn0024811). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; SH3/SH2 adaptor activity. There is experimental evidence that it is involved in the biological process: border follicle cell migration; imaginal disc fusion, thorax closure; positive regulation of JNK cascade. 10 alleles are reported. The phenotypes of these alleles are annotated with: border follicle cell; thorax. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: SH2 domain; Src homology-3 domain; Variant SH3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult heart, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1634217_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Crk. Gene sequence location is 4:230850..233791.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 102A8-102A8
Experimentally Determined Cytological Location
Cytogenetic map Notes References 101F-102A     (Galletta, 1998.12.10) 101F-102A   (determined by in situ hybridisation)   (Galletta et al., 1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Crk for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.43 Gene model reviewed during 5.47 Gene model includes transcripts encoding non-overlapping portions of the full CDS. Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Crk-RA FBtr0089113  NM_143651   1197   271 Crk-RB FBtr0089114  NM_166744   1143   253 Crk-RC FBtr0089112  NM_166743   1122   271 Crk-RD FBtr0304871  NM_001258483   1357   184 Crk-RE FBtr0308256  NM_001258482   1173   263 Crk-RF FBtr0334406  NM_001272119   863   104
Additional Transcript Data & Comments
Reported size (kB)	1.3 (northern blot) (Galletta et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Crk-PA   FBpp0088182   31.2   271   4.86     NP_651908   AAF59362 Crk-PB   FBpp0088183   29.1   253   4.74     NP_726550   AAN06520 Crk-PC   FBpp0088181   31.2   271   4.86     NP_726549   AAN06519 Crk-PD   FBpp0293411   21.4   184   5.32     NP_001245412   AFH06772 Crk-PE   FBpp0300576   30.2   263   4.86     NP_001245411   AFH06771 Crk-PF   FBpp0306509   11.7   104   5.18     NP_001259048   AGB96538
Additional Polypeptide Data & Comments
Reported size (kDa)	271 (aa); 37 (kD observed); 31 (kD predicted) (Galletta et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SH2 domain (IPR000980) Src homology-3 domain (IPR001452) Variant SH3 (IPR011511)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264716   AA820875   AA940639   AE014135 AAF59362   AE014135 AAN06519   AE014135 AAN06520   AC010839   AC011613   AF112976 AAD28428   AE014135 AFH06771   AE014135 AFH06772   AE014135 AGB96538   AW941668   AY061094 AAL28642   BE975694   BE975695   BI173391   BI228838   BI242774   BI373563   BI373572   BI485444   BP546003   BP550060   BP550061   BT012456   BT100035   BT125927   CO178286   CO178404   CO183233   CO195086   CO196384   CO264389   CO268584   CO269351   CO281490   CO282391   CO294637   CO297128   CO297848   CO299492   CO301349   CO302897   CO304244   CO311225   CO311279   CO311579   CO312473   CO315054   CO315284   CO317509   CO329691   CO332709   CO339432   CO344852   CZ470999   CZ481991   EC057114   EC084960   EC085578   EC086819   EC087996   EC202204   EC205706   EC206635   EC213620   EC216632   EC219936   EC222623   EC222941   EC241668   EC248172   EC250696   EC253944   EC254843   EC256733   EV582442   EV599960
UniProtKB/Swiss-Prot	Q9XYM0
UniProtKB/TrEMBL	Q95RW2 H9XVM6 H9XVM7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Galletta et al., 1999) embryonic stage 6 -- 7   mesoderm   (Galletta et al., 1999) embryonic stage 8   cephalic furrow | vicinity of   (Galletta et al., 1999) embryonic stage 8 -- 12   anterior embryonic/larval midgut   (Galletta et al., 1999) posterior embryonic/larval midgut   (Galletta et al., 1999) embryonic stage 13   somatic mesoderm   (Galletta et al., 1999) visceral mesoderm   (Galletta et al., 1999) embryonic stage 13 -- 17   ventral nerve cord   (Galletta et al., 1999) embryonic stage 16   embryonic procephalic segment   (Galletta et al., 1999) muscle fiber   (Galletta et al., 1999) embryonic/larval visceral muscle   (Galletta et al., 1999)
Additional Descriptive Data
	Crk transcripts are abundant throughout embryogenesis, decline in larvae, reappear during pupal stages and are detected in adults on northern blots. Transcripts are first detected by in situ hybridization in stage 4 embryos just prior to cellularization where they are concentrated around the periphery of the embryo. As cellularization occurs, transcripts are still present at the edge of the newly forming cells but not at the termini of the embryo. During gastrulation Crk transcripts are observed in the invaginating mesoderm as well as in some lateral cells that will contribute to ectodermally derived tissue. In stage 8, expression is apparent in the anterior and posterior midgut primordia and in the cells surrounding the cephalic furrow. This expression remains strong through stages 9-12. In late stage 13, Crk transcript expression is strongest in the visceral mesoderm of the anterior and posterior midgut and in the ventral nerve cord. It is also present in the somatic mesoderm but not in the amnioserosa. By stage 16, transcript levels have declined in some tissues but are still strong in visceral musculature, ventral nerve cord, and the cephalic region. Low levels of Crk transcript are detected in mature muscle fibers. (Galletta et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult heart, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1207.55 Larval Midgut    791.4 Larval Hindgut    874.5 Larval Malpighian Tubules    1647.3 Larval Fat Body    924 Larval Salivary Gland    1101.7 Larval Trachea    1094.15 Larval Carcass    1001.55 Adult Head    710 Adult Eye    886.275 Adult Brain    1399.4 Adult Thoracic-Abdominal Ganglion    1274.4 Adult Crop    1590.3 Adult Midgut    745.1 Adult Hindgut    900.9 Adult Malpighian Tubules    1537 Adult Fat Body    595.8 Adult Salivary Gland    1167.4 Adult Heart    446.1 Adult VirginFemale Spermatheca    530.1 Adult InseminatedFemale Spermatheca    546.4 Adult Ovary    1000.6 Adult Testis    333.4 Adult Male Accessory Gland    531.1 Adult Carcass    550.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1207.55) Larval Midgut  (791.4) Larval Hindgut  (874.5) Larval Malpighian Tubules  (1647.3) Larval Fat Body  (924) Larval Salivary Gland  (1101.7) Larval Trachea  (1094.15) Larval Carcass  (1001.55) Adult Head  (710) Adult Eye  (886.275) Adult Brain  (1399.4) Adult Thoracic-Abdominal Ganglion  (1274.4) Adult Crop  (1590.3) Adult Midgut  (745.1) Adult Hindgut  (900.9) Adult Malpighian Tubules  (1537) Adult Fat Body  (595.8) Adult Salivary Gland  (1167.4) Adult Heart    446.1 Adult VirginFemale Spermatheca  530.1 Adult InseminatedFemale Spermatheca  (546.4) Adult Ovary  (1000.6) Adult Testis    333.4 Adult Male Accessory Gland  531.1 Adult Carcass  (550.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1207.55) Larval Midgut    791.4 Larval Hindgut    874.5 Larval Malpighian Tubules  (1647.3) Larval Fat Body    924 Larval Salivary Gland  (1101.7) Larval Trachea  (1094.15) Larval Carcass  1001.55 Adult Head    710 Adult Eye    886.275 Adult Brain  (1399.4) Adult Thoracic-Abdominal Ganglion  (1274.4) Adult Crop  (1590.3) Adult Midgut    745.1 Adult Hindgut    900.9 Adult Malpighian Tubules  (1537) Adult Fat Body    595.8 Adult Salivary Gland  (1167.4) Adult Heart    446.1 Adult VirginFemale Spermatheca    530.1 Adult InseminatedFemale Spermatheca    546.4 Adult Ovary  1000.6 Adult Testis    333.4 Adult Male Accessory Gland    531.1 Adult Carcass    550.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1207.55 Larval Midgut    791.4 Larval Hindgut    874.5 Larval Malpighian Tubules    1647.3 Larval Fat Body    924 Larval Salivary Gland    1101.7 Larval Trachea    1094.15 Larval Carcass    1001.55 Adult Head    710 Adult Eye    886.275 Adult Brain    1399.4 Adult Thoracic-Abdominal Ganglion    1274.4 Adult Crop    1590.3 Adult Midgut    745.1 Adult Hindgut    900.9 Adult Malpighian Tubules    1537 Adult Fat Body    595.8 Adult Salivary Gland    1167.4 Adult Heart    446.1 Adult VirginFemale Spermatheca    530.1 Adult InseminatedFemale Spermatheca    546.4 Adult Ovary    1000.6 Adult Testis    333.4 Adult Male Accessory Gland    531.1 Adult Carcass    550.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1207.55 Larval Midgut    791.4 Larval Hindgut    874.5 Larval Malpighian Tubules    1647.3 Larval Fat Body    924 Larval Salivary Gland    1101.7 Larval Trachea    1094.15 Larval Carcass    1001.55 Adult Head    710 Adult Eye    886.275 Adult Brain    1399.4 Adult Thoracic-Abdominal Ganglion    1274.4 Adult Crop    1590.3 Adult Midgut    745.1 Adult Hindgut    900.9 Adult Malpighian Tubules    1537 Adult Fat Body    595.8 Adult Salivary Gland    1167.4 Adult Heart    446.1 Adult VirginFemale Spermatheca    530.1 Adult InseminatedFemale Spermatheca    546.4 Adult Ovary    1000.6 Adult Testis    333.4 Adult Male Accessory Gland    531.1 Adult Carcass    550.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1207.55) Larval Midgut  791.4 Larval Hindgut  (874.5) Larval Malpighian Tubules  (1647.3) Larval Fat Body  (924) Larval Salivary Gland  (1101.7) Larval Trachea  (1094.15) Larval Carcass  (1001.55) Adult Head  710 Adult Eye  (886.275) Adult Brain  (1399.4) Adult Thoracic-Abdominal Ganglion  (1274.4) Adult Crop  (1590.3) Adult Midgut  745.1 Adult Hindgut  (900.9) Adult Malpighian Tubules  (1537) Adult Fat Body  595.8 Adult Salivary Gland  (1167.4) Adult Heart    446.1 Adult VirginFemale Spermatheca  530.1 Adult InseminatedFemale Spermatheca  546.4 Adult Ovary  (1000.6) Adult Testis    333.4 Adult Male Accessory Gland  531.1 Adult Carcass  550.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1207.55 Larval Midgut    791.4 Larval Hindgut    874.5 Larval Malpighian Tubules  1647.3 Larval Fat Body    924 Larval Salivary Gland  1101.7 Larval Trachea  1094.15 Larval Carcass  1001.55 Adult Head    710 Adult Eye    886.275 Adult Brain  1399.4 Adult Thoracic-Abdominal Ganglion  1274.4 Adult Crop  1590.3 Adult Midgut    745.1 Adult Hindgut    900.9 Adult Malpighian Tubules  1537 Adult Fat Body    595.8 Adult Salivary Gland  1167.4 Adult Heart    446.1 Adult VirginFemale Spermatheca    530.1 Adult InseminatedFemale Spermatheca    546.4 Adult Ovary  1000.6 Adult Testis    333.4 Adult Male Accessory Gland    531.1 Adult Carcass    550.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1207.55 Larval Midgut    791.4 Larval Hindgut    874.5 Larval Malpighian Tubules    1647.3 Larval Fat Body    924 Larval Salivary Gland    1101.7 Larval Trachea    1094.15 Larval Carcass    1001.55 Adult Head    710 Adult Eye    886.275 Adult Brain    1399.4 Adult Thoracic-Abdominal Ganglion    1274.4 Adult Crop    1590.3 Adult Midgut    745.1 Adult Hindgut    900.9 Adult Malpighian Tubules    1537 Adult Fat Body    595.8 Adult Salivary Gland    1167.4 Adult Heart    446.1 Adult VirginFemale Spermatheca    530.1 Adult InseminatedFemale Spermatheca    546.4 Adult Ovary    1000.6 Adult Testis    333.4 Adult Male Accessory Gland    531.1 Adult Carcass    550.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    710   NA  Eye    886.275   NA  Brain    1399.4   1207.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1274.4   NA  Crop    1590.3   791.4  Midgut    745.1   874.5  Hindgut    900.9   1647.3  Malpighian Tubules    1537   924  Fat Body    595.8   1101.7  Salivary Gland    1167.4   NA  Heart    446.1   1094.15  Trachea    NA   NA  VirginFemale Spermatheca    530.1   NA  InseminatedFemale Spermatheca    546.4   NA  Ovary    1000.6   NA  Testis    333.4   NA  Male Accessory Gland    531.1   1001.55  Carcass    550.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    29 central nervous system, pupae P8    41 head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    9 head, mated 1-day female    14 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    11 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female    42 ovary, mated 4-day female    30 testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3  (29) central nervous system, pupae P8  (41) head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    9 head, mated 1-day female    14 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male  (28) head, mated 20-day male    22 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    11 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female  (42) ovary, mated 4-day female  (30) testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    29 central nervous system, pupae P8    41 head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    9 head, mated 1-day female    14 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    11 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female    42 ovary, mated 4-day female    30 testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    29 central nervous system, pupae P8    41 head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    9 head, mated 1-day female    14 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    11 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female    42 ovary, mated 4-day female    30 testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    29 central nervous system, pupae P8    41 head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    9 head, mated 1-day female    14 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    11 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female    42 ovary, mated 4-day female    30 testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3  29 central nervous system, pupae P8  (41) head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    9 head, mated 1-day female    14 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male  28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    11 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female  (42) ovary, mated 4-day female  30 testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    29 central nervous system, pupae P8    41 head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    9 head, mated 1-day female    14 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    11 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female    42 ovary, mated 4-day female    30 testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    29 central nervous system, pupae P8    41 head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    9 head, mated 1-day female    14 head, mated 4-day female    15 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    28 head, mated 20-day male    22 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    14 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    11 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female    42 ovary, mated 4-day female    30 testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    41 embryo 04-06hr    48 embryo 06-08hr    37 embryo 08-10hr    53 embryo 10-12hr    42 embryo 12-14hr    58 embryo 14-16hr    14 embryo 16-18hr    28 embryo 18-20hr    12 embryo 20-22hr    16 embryo 22-24hr    32 larva L1    12 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    41 white prepupae new    43 white prepupae 12hr    41 white prepupae 24hr    40 pupae 2d postWPP    42 pupae 3d postWPP    26 pupae 4d postWPP    9 adult male 01day    16 adult male 05day    10 adult male 30day    7 adult female 01day    9 adult female 05day    31 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (29) embryo 02-04hr  (41) embryo 04-06hr  (48) embryo 06-08hr  (37) embryo 08-10hr  (53) embryo 10-12hr  (42) embryo 12-14hr  (58) embryo 14-16hr    14 embryo 16-18hr  (28) embryo 18-20hr    12 embryo 20-22hr    16 embryo 22-24hr  (32) larva L1    12 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  (41) white prepupae new  (43) white prepupae 12hr  (41) white prepupae 24hr  (40) pupae 2d postWPP  (42) pupae 3d postWPP  26 pupae 4d postWPP    9 adult male 01day    16 adult male 05day    10 adult male 30day    7 adult female 01day    9 adult female 05day  (31) adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    41 embryo 04-06hr    48 embryo 06-08hr    37 embryo 08-10hr    53 embryo 10-12hr    42 embryo 12-14hr    58 embryo 14-16hr    14 embryo 16-18hr    28 embryo 18-20hr    12 embryo 20-22hr    16 embryo 22-24hr    32 larva L1    12 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    41 white prepupae new    43 white prepupae 12hr    41 white prepupae 24hr    40 pupae 2d postWPP    42 pupae 3d postWPP    26 pupae 4d postWPP    9 adult male 01day    16 adult male 05day    10 adult male 30day    7 adult female 01day    9 adult female 05day    31 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    41 embryo 04-06hr    48 embryo 06-08hr    37 embryo 08-10hr    53 embryo 10-12hr    42 embryo 12-14hr    58 embryo 14-16hr    14 embryo 16-18hr    28 embryo 18-20hr    12 embryo 20-22hr    16 embryo 22-24hr    32 larva L1    12 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    41 white prepupae new    43 white prepupae 12hr    41 white prepupae 24hr    40 pupae 2d postWPP    42 pupae 3d postWPP    26 pupae 4d postWPP    9 adult male 01day    16 adult male 05day    10 adult male 30day    7 adult female 01day    9 adult female 05day    31 adult female 30day    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    41 embryo 04-06hr    48 embryo 06-08hr    37 embryo 08-10hr    53 embryo 10-12hr    42 embryo 12-14hr    58 embryo 14-16hr    14 embryo 16-18hr    28 embryo 18-20hr    12 embryo 20-22hr    16 embryo 22-24hr    32 larva L1    12 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    41 white prepupae new    43 white prepupae 12hr    41 white prepupae 24hr    40 pupae 2d postWPP    42 pupae 3d postWPP    26 pupae 4d postWPP    9 adult male 01day    16 adult male 05day    10 adult male 30day    7 adult female 01day    9 adult female 05day    31 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  29 embryo 02-04hr  (41) embryo 04-06hr  (48) embryo 06-08hr  (37) embryo 08-10hr  (53) embryo 10-12hr  (42) embryo 12-14hr  (58) embryo 14-16hr    14 embryo 16-18hr  28 embryo 18-20hr    12 embryo 20-22hr    16 embryo 22-24hr  32 larva L1    12 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  (41) white prepupae new  (43) white prepupae 12hr  (41) white prepupae 24hr  (40) pupae 2d postWPP  (42) pupae 3d postWPP  26 pupae 4d postWPP    9 adult male 01day    16 adult male 05day    10 adult male 30day    7 adult female 01day    9 adult female 05day  31 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    41 embryo 04-06hr    48 embryo 06-08hr    37 embryo 08-10hr    53 embryo 10-12hr    42 embryo 12-14hr    58 embryo 14-16hr    14 embryo 16-18hr    28 embryo 18-20hr    12 embryo 20-22hr    16 embryo 22-24hr    32 larva L1    12 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    41 white prepupae new    43 white prepupae 12hr    41 white prepupae 24hr    40 pupae 2d postWPP    42 pupae 3d postWPP    26 pupae 4d postWPP    9 adult male 01day    16 adult male 05day    10 adult male 30day    7 adult female 01day    9 adult female 05day    31 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    41 embryo 04-06hr    48 embryo 06-08hr    37 embryo 08-10hr    53 embryo 10-12hr    42 embryo 12-14hr    58 embryo 14-16hr    14 embryo 16-18hr    28 embryo 18-20hr    12 embryo 20-22hr    16 embryo 22-24hr    32 larva L1    12 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    41 white prepupae new    43 white prepupae 12hr    41 white prepupae 24hr    40 pupae 2d postWPP    42 pupae 3d postWPP    26 pupae 4d postWPP    9 adult male 01day    16 adult male 05day    10 adult male 30day    7 adult female 01day    9 adult female 05day    31 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    19 embryonic 1182-4H    9 embryonic GM2    69 embryonic Kc167    60 embryonic S1    14 embryonic S3    40 leg disc CME L1    7 wing disc CME-W2    44 wing disc ML-DmD8    66 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    48 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4    19 embryonic 1182-4H    9 embryonic GM2  (69) embryonic Kc167  (60) embryonic S1    14 embryonic S3  (40) leg disc CME L1    7 wing disc CME-W2  (44) wing disc ML-DmD8  (66) wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  (35) eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5  (28) mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2  (48) ovary fGS/OSS    11 ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    19 embryonic 1182-4H    9 embryonic GM2    69 embryonic Kc167    60 embryonic S1    14 embryonic S3    40 leg disc CME L1    7 wing disc CME-W2    44 wing disc ML-DmD8    66 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    48 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    19 embryonic 1182-4H    9 embryonic GM2    69 embryonic Kc167    60 embryonic S1    14 embryonic S3    40 leg disc CME L1    7 wing disc CME-W2    44 wing disc ML-DmD8    66 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    48 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    19 embryonic 1182-4H    9 embryonic GM2    69 embryonic Kc167    60 embryonic S1    14 embryonic S3    40 leg disc CME L1    7 wing disc CME-W2    44 wing disc ML-DmD8    66 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    48 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4    19 embryonic 1182-4H    9 embryonic GM2  (69) embryonic Kc167  (60) embryonic S1    14 embryonic S3  (40) leg disc CME L1    7 wing disc CME-W2  (44) wing disc ML-DmD8  (66) wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  (35) eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5  28 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2  (48) ovary fGS/OSS    11 ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    19 embryonic 1182-4H    9 embryonic GM2    69 embryonic Kc167    60 embryonic S1    14 embryonic S3    40 leg disc CME L1    7 wing disc CME-W2    44 wing disc ML-DmD8    66 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    48 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    19 embryonic 1182-4H    9 embryonic GM2    69 embryonic Kc167    60 embryonic S1    14 embryonic S3    40 leg disc CME L1    7 wing disc CME-W2    44 wing disc ML-DmD8    66 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    48 ovary fGS/OSS    11 ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    33 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3  (33) Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult  (68) Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    33 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    33 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    33 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3  (33) Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult  (68) Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    33 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    33 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    25 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RE60886 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024811 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1587-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive CrkKG00336 viable, with Scer\GAL4pnr-MD237 CrkGD8583 Phenotype manifest in Allele border follicle cell, with Scer\GAL4slbo.2.6 CrkdsRNA.Scer\UAS thorax, with Scer\GAL4pnr-MD237 CrkdsRNA.Scer\UAS
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Crk Class Mutagen Stocks Known lesion Crkc06803 piggyBac transposase 1 -- Crke04246 piggyBac transposase 1 -- CrkKG00336 1 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Crk Class Mutagen Stocks Known lesion CrkGD8583 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CrkKK108690 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CrkdsRNA.cIa in vitro construct - RNAi 0 Yes CrkdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CrkScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CrkSH2L.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 -- CrkSH2S.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 --
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8583} NA P{KK108690} NA P{UAS-Crk.FLAG} NA P{UAS-Crk.IR} NA P{UAS-Crk.SH2L.FLAG} NA P{UAS-Crk.SH2S.FLAG} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}CrkKG00336 NA PBac{PB}Crkc06803 NA PBac{RB}Crke04246 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Pvr (Ishimaru et al., 2004) SH3/SH2 adaptor activity inferred from direct assay (Ishimaru et al., 2004)
Biological Process
CV term Evidence References
border follicle cell migration inferred from mutant phenotype (Geisbrecht et al., 2008) imaginal disc fusion, thorax closure inferred from mutant phenotype (Ishimaru et al., 2004) positive regulation of JNK cascade inferred from direct assay (Ishimaru et al., 2004)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
SH3/SH2 adaptor activity inferred from sequence or structural similarity with UniProtKB:P87378 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Biological Process
CV term Evidence References
myoblast fusion traceable author statement (Dworak and Sink, 2002) signal transduction non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Crk - 128up anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Adh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Arpc3A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG13472 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG14696 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG15220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG16753 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG2021 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG2199 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG3091 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Crk - CG3436 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG3548 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG42232 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG6617 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - CG8142 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - DnaJ-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Gnf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Ku80 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - LRP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - LSm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Mi-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Ote anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Psi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - RPA2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - RfC38 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Rrp40 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Sec23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - Srp54 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - TFAM anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - bocksbeutel anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - eIF3-S8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - ens anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - l(2)37Cb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - mRpL15 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - mRpL20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - mRpL21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - mRpL43 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - nonA-l anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - prod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Crk - α-Spec anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Crk allele Gene References CrkKG00336 Pvr (Ishimaru et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68612 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0024811 DroID - A comprehensive database of gene and protein interactions. • FBgn0024811 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43775 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9XYM0
Orthologs
OrthoDB Orthologs (44) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6THWD6 Dipteran inclusive ortholog search EOG6XPQQS Insect inclusive ortholog search EOG6BP087 Arthropod inclusive ortholog search EOG6BK3M7 Metazoa inclusive ortholog search EOG6JHR8J
Orthologs in Drosophila Species (EOG6THWD6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Crk     Drosophila simulans   Dsim\GD14194     Drosophila sechellia   Dsec\GM23242 Y   Drosophila erecta   Dere\GG16379 Y   Drosophila yakuba   Dyak\GE14540 Y   Drosophila ananassae   Dana\GF23415 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13993 Y   Drosophila persimilis   Dper\GL18154 Y   Drosophila willistoni   Dwil\GK13611 Y   Drosophila virilis   Dvir\GJ18986 Y   Drosophila mojavensis   Dmoj\GI14066 Y   Drosophila grimshawi   Dgri\GH23941 Y
Orthologs in non-Drosophila Dipterans (EOG6XPQQS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006523   Anopheles gambiae Malaria mosquito  Agam\AGAP009499   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801880
Orthologs in non-Dipteran Insects (EOG6BP087)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43554   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007651   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15073   Atta cephalotes Leafcutter ant  Acep\ACEP27121   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17326   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13493   Linepithema humile Argentine ant  Lhum\LH16953   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17979   Solenopsis invicta Red fire ant  Sinv\SINV23531   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005626   Bombyx mori Silkmoth  Bmor\BGIBMGA013349   Pediculus humanus Human body louse  Phum\PHUM332570   Tribolium castaneum Red flour beetle  Tcas\TC004767
Orthologs in non-Insect Arthropods (EOG6BK3M7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ZHFX1b   Ixodes scapularis Deer tick  Isca\ISCW020669
Orthologs in non-Arthropod Metazoa (EOG6JHR8J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ced-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016214gn   Danio rerio Zebrafish  Drer\crk   Danio rerio Zebrafish  Drer\crkl   Xenopus tropicalis Western clawed frog  Xtro\crk   Xenopus tropicalis Western clawed frog  Xtro\crkl   Gallus gallus Domestic chicken  Ggal\CRKL   Gallus gallus Domestic chicken  Ggal\CRK   Mus musculus House mouse  Mmus\Crkl   Mus musculus House mouse  Mmus\Crk   Rattus norvegicus Norway rat  Rnor\Crk   Rattus norvegicus Norway rat  Rnor\Crkl   Homo sapiens Human  Hsap\CRK   Homo sapiens Human  Hsap\CRKL
Human Orthologs (2)
Gene OMIM HGNC Hsap\CRK     Hsap\CRKL
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Crk Drosophila sechellia Dsec\GM23242 Drosophila erecta Dere\GG16379 Drosophila yakuba Dyak\GE14540 Drosophila ananassae Dana\GF23415 Drosophila pseudoobscura pseudoobscura Dpse\GA13993 Drosophila persimilis Dper\GL18154 Drosophila willistoni Dwil\GK13611 Drosophila virilis Dvir\GJ18986 Drosophila mojavensis Dmoj\GI14066 Drosophila grimshawi Dgri\GH23941
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	13652 y1; ry506; P{SUPor-P}CrkKG00336/In(4)ciD, ciD panciD
Harvard	- PBac{PB}Crkc06803 - PBac{RB}Crke04246
VDRC	v106498 P{KK108690}VIE-260B v19061 w1118; P{GD8583}v19061
Genomic Clones ( 1 )
	BACN19N21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 62 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD08427 RE43277 RE60886
Other clones	DPiM_RE60886 MIP14750
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD22148 LD24801 RE16301 RE26485 RE40193 RE60895 RE68766
Other clones	43953 47463 54729 56935 75398 101252 102221 105813 190987 214277.9 214375.10 214417.3 277205 bs44c03 CK01.40B.B10 CK01.71B.A6 CK01.115B.E5 CK01.120C.A10 Dmel_dig_003336_0642_2598 Dmel_neb_011055_0898_2107 EC25225 EC39686 EK004015 EK056322 EK056635 EK092026 EK094206 EK138934 EK157309 EK160352 EK170660 EK175549 EK180757 EK185117 EK207337 EK216055 EK223813 EK224027 EK225356 EK228901 EK238856 EK244162 EK260945 EK268404 EK293528 EK304325 EP01956 EP20025 FGH101G10 FGM105A11
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024811 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43775
Antibody Information
	polyclonal (Galletta et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Crk CG1587 (Zhong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Isolated in an embryonic expression library screened with the consensus SRK-binding site found in mbc. (Galletta et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143651 NM_166743 NM_166744 NM_001258482 NM_001258483 NM_001272119 RefSeq (Proteins) • NP_651908 NP_726549 NP_726550 NP_001245411 NP_001245412 NP_001259048 DDBJ / EMBL / GenBank • AA264716 AAD28428 AAF59362 AAL28642 AAN06519 AAN06520 AC010839 AC011613 AF112976 AFH06771 AFH06772 AGB96538 AW941668 AY061094 BI373563 CZ470999 CZ481991 Entrez Gene - A searchable database of RefSeq genes. • 43775 UniProtKB/Swiss-Prot • Q9XYM0 UniProtKB/TrEMBL • H9XVM6 H9XVM7 Q95RW2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SH2 domain (IPR000980) Src homology-3 domain (IPR001452) Variant SH3 (IPR011511) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE60886
Linkouts
	BioGRID - A database of protein and genetic interactions • 68612 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0024811 DroID - A comprehensive database of gene and protein interactions. • FBgn0024811 DRSC - Results from RNAi screens. • FBgn0024811 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024811 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1587-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024811 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43775 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43775 modMine - Data generated by the modENCODE project. • FBgn0024811 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9XYM0
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG1587 (Labourier et al., 2002, Sang and Ready, 2002, Keleman et al., 2009.8.5, Malko et al., 2006) CRK (Balagopalan et al., 2003, Geisbrecht et al., 2008) Crk (Geisbrecht et al., 2007, Chen, 2007, Masly et al., 2006, Chen et al., 2007, Meller et al., 2005, Ridley, 2001, Johansson et al., 2007, Zhou et al., 2008, Deng et al., 2009, Elwell et al., 2008, Kim et al., 2007, McPhee et al., 2010, Jin et al., 2011, Dalton et al., 2010, Pielage et al., 2008, Ziegenfuss et al., 2012) crk (McPhee et al., 2010) dCrk (Woodcock and Hughes, 2004) DCrk (Chen and Olson, 2004, Balagopalan et al., 2006) Dcrk (Reif and Cyster, 2002, Potter et al., 2000) D-Crk (Dworak and Sink, 2002) dCRK (Galletta et al., 1999) D-CRK (Galletta et al., 1997)
Name Synonym	Crk (Johansson et al., 2007, Zhou et al., 2008, McPhee et al., 2010)
Secondary FlyBase IDs
References ( 57 )
Generate a list of	All references relating to this gene ( 57 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 7 ) Review  ( 9 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 5 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 3 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 2 )
	Ziegenfuss et al., 2012, Nat. Neurosci. 15(7): 979--987 Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy. [FBrf0218752] Jin et al., 2011, Dev. Cell 20(5): 623--638 Competition between Blown Fuse and WASP for WIP Binding Regulates the Dynamics of WASP-Dependent Actin Polymerization In Vivo. [FBrf0213682] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...