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Gene Dmel\AP-1μ

General Information
Symbol	Dmel\AP-1μ	Species	D. melanogaster
Name	Adaptor Protein complex 1, μ subunit	Annotation symbol	CG9388
Feature type	protein_coding_gene	FlyBase ID	FBgn0024833
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	AP47, μ1, AP-1μ1, AP-47, apm1
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85D24-85D24	Sequence location	3R:5,383,434..5,385,247 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Adaptor Protein complex 1, μ subunit is referred to in FlyBase by the symbol Dmel\AP-1μ (CG9388, FBgn0024833). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein transporter activity. There is experimental evidence that it is involved in the biological process: negative regulation of Notch signaling pathway; secretory granule organization; compound eye development; negative regulation of endocytic recycling; intracellular transport. 8 alleles are reported. The phenotypes of these alleles are annotated with: eye; secretory granule; mesothoracic tergum; ommatidium. It has one annotated transcript and one annotated polypeptide. Protein features are: AP complex, mu/sigma subunit; Clathrin adaptor, mu subunit; Clathrin adaptor, mu subunit, C-terminal; Clathrin adaptor, mu subunit, conserved site; Longin-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1623631_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of AP-47. Gene sequence location is 3R:5383434..5385247.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85D24-85D24   Limits computationally determined from genome sequence between P{PZ}ps10615&P{PZ}Ras85D06677 and P{EP}CG9393EP3122
Experimentally Determined Cytological Location
Cytogenetic map Notes References 85D-85D     (Zhang, 1998.5.14) 85D20-85D23     (Mullins, 1998.12.1) 85D20-85D27   (determined by in situ hybridisation)   (Zhang and Broadie, 1999) 85D-85D   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\AP-1μ for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) AP-1μ-RA FBtr0082114  NM_141649   1755   426
Additional Transcript Data & Comments
Reported size (kB)	1.756 (sequence analysis) (Zhang and Broadie, 1999) 1.717 (sequence analysis) (Mullins et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein AP-1μ-PA   FBpp0081592   48.9   426   7.21     NP_649906   AAF54399
Additional Polypeptide Data & Comments
Reported size (kDa)	426 (aa) (Zhang and Broadie, 1999, Mullins et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Clathrin adaptor, mu subunit (IPR001392) Clathrin adaptor, mu subunit, C-terminal (IPR008968) Longin-like domain (IPR011012) Clathrin adaptor, mu subunit, conserved site (IPR018240) AP complex, mu/sigma subunit (IPR022775)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201579   AA201786   AA202691   AA246655   AA264325   AA264458   AA438457   AA439786   AA439826   AA440963   AA441214   AA695884   AA941153   AA942559   AA949032   AA951092   AA951487   AA990650   AE014297 AAF54399   AF110231 AAF14247   AI258901   AI258922   AI511697   AI511977   AI512128   AI513400   AI515093   AI515094   AI516081   AI517516   AI519541   AI532180   AI541967   AI546372   AJ006219 CAA06918   AQ074009   AW943081   AY058621 AAL13850   BF500110   BG640112   BG640202   BI164454   BI164508   BI165366   BI169128   BI214180   BI214334   BI233015   BI237857   BI240526   BI241383   BI242854   BI242860   BI352560   BI357606   BI361347   BI370061   BI375536   BI486023   BI486337   BI580585   BI606026   BI617274   BI631299   BI633756   BI641585   BQ103697   BT001492   CO192177   CO306253   CO318486   EC202725   EC204335   EC204336   EC237814   EL872763   GH751927   GH756224   GH756633   GH757485   GH760333   GH774073   GH775374   GH775783   GH775885   GH780647   GH781716   GH784124   GH784512   GH786885   GH786932   GH787032   GH788290   GH788939   GH790506   GH793341   GH793443   GH793500   GH798785   GH800852   GH801783   GH802944   GH804496   GH804543   GH806243   GH806470   GH806632   GH808301   GH809340   GH809756   GH812391   GH813951   GH814085   GH816577   GH816740   GH817237   GH817344   GH818871   GH828025   GH830406   GH830961   GH834519   GH834683   GH836233   GH836781   GH837716   GH839639   GH841012   GH841072   GH841963   GH842998   GH843192   GH843624   GH846170   GH846427   GH850984   GH852349   GH854602   GH854865   GH856062   GH858220   GH858850   GH859235   GH860216   GH860332   GH860477   GH861876   GH862430   GH864479   GH865327   GH866386   GH870082   GH870688   GH871201   GH872531   GH872596   GH873757   GH874012   GH874200   GH875972   GH878004   GH878345   GH879121   GH885428   GH889604   GH890224   GH890816   GH891832   GH897294   GH903040   GH903961   GH904330   GH905974   GH906268   GH906586   GH907524   GH907900   GH909309   GH911121   GH913364   GH917858   GH920261   GH920661   GH923144   GH923998   GH925018   GH925522   GH926086   GH926834   GH927341   GH929381   GH930386   GH933199   GH933793   GH937306
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O62531
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Mullins et al., 1999)
Additional Descriptive Data
	AP-1mu transcripts are detected at all stages of development tested. (Mullins et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
AP1 complex inferred from mutant phenotype (Kametaka et al., 2012) inferred from physical interaction with AP-1γ (Kametaka et al., 2012) clathrin-coated vesicle inferred from direct assay (Hirst et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    221.575 Larval Midgut    264.7 Larval Hindgut    287.5 Larval Malpighian Tubules    499.1 Larval Fat Body    163.5 Larval Salivary Gland    499 Larval Trachea    275 Larval Carcass    189.975 Adult Head    254.8 Adult Eye    463.125 Adult Brain    340.2 Adult Thoracic-Abdominal Ganglion    239 Adult Crop    272.5 Adult Midgut    244.3 Adult Hindgut    336.1 Adult Malpighian Tubules    441.9 Adult Fat Body    83 Adult Salivary Gland    568.9 Adult Heart    105.5 Adult VirginFemale Spermatheca    130.4 Adult InseminatedFemale Spermatheca    128.4 Adult Ovary    330.1 Adult Testis    108 Adult Male Accessory Gland    303.9 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    221.575 Larval Midgut    264.7 Larval Hindgut    287.5 Larval Malpighian Tubules    499.1 Larval Fat Body    163.5 Larval Salivary Gland    499 Larval Trachea    275 Larval Carcass    189.975 Adult Head    254.8 Adult Eye    463.125 Adult Brain    340.2 Adult Thoracic-Abdominal Ganglion    239 Adult Crop    272.5 Adult Midgut    244.3 Adult Hindgut    336.1 Adult Malpighian Tubules    441.9 Adult Fat Body    83 Adult Salivary Gland  (568.9) Adult Heart    105.5 Adult VirginFemale Spermatheca    130.4 Adult InseminatedFemale Spermatheca    128.4 Adult Ovary    330.1 Adult Testis    108 Adult Male Accessory Gland    303.9 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    221.575 Larval Midgut    264.7 Larval Hindgut    287.5 Larval Malpighian Tubules    499.1 Larval Fat Body    163.5 Larval Salivary Gland    499 Larval Trachea    275 Larval Carcass    189.975 Adult Head    254.8 Adult Eye    463.125 Adult Brain    340.2 Adult Thoracic-Abdominal Ganglion    239 Adult Crop    272.5 Adult Midgut    244.3 Adult Hindgut    336.1 Adult Malpighian Tubules    441.9 Adult Fat Body    83 Adult Salivary Gland    568.9 Adult Heart    105.5 Adult VirginFemale Spermatheca    130.4 Adult InseminatedFemale Spermatheca    128.4 Adult Ovary    330.1 Adult Testis    108 Adult Male Accessory Gland    303.9 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    221.575 Larval Midgut    264.7 Larval Hindgut    287.5 Larval Malpighian Tubules    499.1 Larval Fat Body    163.5 Larval Salivary Gland    499 Larval Trachea    275 Larval Carcass    189.975 Adult Head    254.8 Adult Eye    463.125 Adult Brain    340.2 Adult Thoracic-Abdominal Ganglion    239 Adult Crop    272.5 Adult Midgut    244.3 Adult Hindgut    336.1 Adult Malpighian Tubules    441.9 Adult Fat Body    83 Adult Salivary Gland    568.9 Adult Heart    105.5 Adult VirginFemale Spermatheca    130.4 Adult InseminatedFemale Spermatheca    128.4 Adult Ovary    330.1 Adult Testis    108 Adult Male Accessory Gland    303.9 Adult Carcass    130.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    221.575 Larval Midgut    264.7 Larval Hindgut    287.5 Larval Malpighian Tubules    499.1 Larval Fat Body    163.5 Larval Salivary Gland    499 Larval Trachea    275 Larval Carcass    189.975 Adult Head    254.8 Adult Eye    463.125 Adult Brain    340.2 Adult Thoracic-Abdominal Ganglion    239 Adult Crop    272.5 Adult Midgut    244.3 Adult Hindgut    336.1 Adult Malpighian Tubules    441.9 Adult Fat Body    83 Adult Salivary Gland    568.9 Adult Heart    105.5 Adult VirginFemale Spermatheca    130.4 Adult InseminatedFemale Spermatheca    128.4 Adult Ovary    330.1 Adult Testis    108 Adult Male Accessory Gland    303.9 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    221.575 Larval Midgut    264.7 Larval Hindgut    287.5 Larval Malpighian Tubules    499.1 Larval Fat Body    163.5 Larval Salivary Gland    499 Larval Trachea    275 Larval Carcass    189.975 Adult Head    254.8 Adult Eye    463.125 Adult Brain    340.2 Adult Thoracic-Abdominal Ganglion    239 Adult Crop    272.5 Adult Midgut    244.3 Adult Hindgut    336.1 Adult Malpighian Tubules    441.9 Adult Fat Body    83 Adult Salivary Gland  568.9 Adult Heart    105.5 Adult VirginFemale Spermatheca    130.4 Adult InseminatedFemale Spermatheca    128.4 Adult Ovary    330.1 Adult Testis    108 Adult Male Accessory Gland    303.9 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    221.575 Larval Midgut    264.7 Larval Hindgut    287.5 Larval Malpighian Tubules    499.1 Larval Fat Body    163.5 Larval Salivary Gland    499 Larval Trachea    275 Larval Carcass    189.975 Adult Head    254.8 Adult Eye    463.125 Adult Brain    340.2 Adult Thoracic-Abdominal Ganglion    239 Adult Crop    272.5 Adult Midgut    244.3 Adult Hindgut    336.1 Adult Malpighian Tubules    441.9 Adult Fat Body    83 Adult Salivary Gland    568.9 Adult Heart    105.5 Adult VirginFemale Spermatheca    130.4 Adult InseminatedFemale Spermatheca    128.4 Adult Ovary    330.1 Adult Testis    108 Adult Male Accessory Gland    303.9 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    221.575 Larval Midgut    264.7 Larval Hindgut    287.5 Larval Malpighian Tubules    499.1 Larval Fat Body    163.5 Larval Salivary Gland    499 Larval Trachea    275 Larval Carcass    189.975 Adult Head    254.8 Adult Eye    463.125 Adult Brain    340.2 Adult Thoracic-Abdominal Ganglion    239 Adult Crop    272.5 Adult Midgut    244.3 Adult Hindgut    336.1 Adult Malpighian Tubules    441.9 Adult Fat Body    83 Adult Salivary Gland    568.9 Adult Heart    105.5 Adult VirginFemale Spermatheca    130.4 Adult InseminatedFemale Spermatheca    128.4 Adult Ovary    330.1 Adult Testis    108 Adult Male Accessory Gland    303.9 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    254.8   NA  Eye    463.125   NA  Brain    340.2   221.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    239   NA  Crop    272.5   264.7  Midgut    244.3   287.5  Hindgut    336.1   499.1  Malpighian Tubules    441.9   163.5  Fat Body    83   499  Salivary Gland    568.9   NA  Heart    105.5   275  Trachea    NA   NA  VirginFemale Spermatheca    130.4   NA  InseminatedFemale Spermatheca    128.4   NA  Ovary    330.1   NA  Testis    108   NA  Male Accessory Gland    303.9   189.975  Carcass    130.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    36 central nervous system, pupae P8    20 head, virgin 1-day female    18 head, virgin 4-day female    19 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    15 head, mated 1-day male    25 head, mated 4-day male    30 head, mated 20-day male    41 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    28 digestive system, 4-day adult    33 digestive system, 20-day adult    35 fat body, larvae L3 wandering    9 fat body, white prepupae    16 fat body, pupae P8    26 carcass, larvae L3 wandering    35 carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    14 ovary, virgin 4-day female    57 ovary, mated 4-day female    54 testis, mated 4-day male    21 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (35) central nervous system, larvae L3  (36) central nervous system, pupae P8    20 head, virgin 1-day female    18 head, virgin 4-day female    19 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    15 head, mated 1-day male    25 head, mated 4-day male  (30) head, mated 20-day male  (41) salivary gland, larvae L3 wandering    16 salivary gland, white prepupae  (48) digestive system, larvae L3 wandering  (34) digestive system, 1-day adult  (28) digestive system, 4-day adult  (33) digestive system, 20-day adult  (35) fat body, larvae L3 wandering    9 fat body, white prepupae    16 fat body, pupae P8  26 carcass, larvae L3 wandering  (35) carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    14 ovary, virgin 4-day female  (57) ovary, mated 4-day female  (54) testis, mated 4-day male    21 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    36 central nervous system, pupae P8    20 head, virgin 1-day female    18 head, virgin 4-day female    19 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    15 head, mated 1-day male    25 head, mated 4-day male    30 head, mated 20-day male    41 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    28 digestive system, 4-day adult    33 digestive system, 20-day adult    35 fat body, larvae L3 wandering    9 fat body, white prepupae    16 fat body, pupae P8    26 carcass, larvae L3 wandering    35 carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    14 ovary, virgin 4-day female    57 ovary, mated 4-day female    54 testis, mated 4-day male    21 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    36 central nervous system, pupae P8    20 head, virgin 1-day female    18 head, virgin 4-day female    19 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    15 head, mated 1-day male    25 head, mated 4-day male    30 head, mated 20-day male    41 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    28 digestive system, 4-day adult    33 digestive system, 20-day adult    35 fat body, larvae L3 wandering    9 fat body, white prepupae    16 fat body, pupae P8    26 carcass, larvae L3 wandering    35 carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    14 ovary, virgin 4-day female    57 ovary, mated 4-day female    54 testis, mated 4-day male    21 accessory gland, mated 4-day male    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    36 central nervous system, pupae P8    20 head, virgin 1-day female    18 head, virgin 4-day female    19 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    15 head, mated 1-day male    25 head, mated 4-day male    30 head, mated 20-day male    41 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    28 digestive system, 4-day adult    33 digestive system, 20-day adult    35 fat body, larvae L3 wandering    9 fat body, white prepupae    16 fat body, pupae P8    26 carcass, larvae L3 wandering    35 carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    14 ovary, virgin 4-day female    57 ovary, mated 4-day female    54 testis, mated 4-day male    21 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (35) central nervous system, larvae L3  (36) central nervous system, pupae P8    20 head, virgin 1-day female    18 head, virgin 4-day female    19 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    15 head, mated 1-day male    25 head, mated 4-day male  30 head, mated 20-day male  (41) salivary gland, larvae L3 wandering    16 salivary gland, white prepupae  (48) digestive system, larvae L3 wandering  (34) digestive system, 1-day adult  28 digestive system, 4-day adult  (33) digestive system, 20-day adult  (35) fat body, larvae L3 wandering    9 fat body, white prepupae    16 fat body, pupae P8  26 carcass, larvae L3 wandering  (35) carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    14 ovary, virgin 4-day female  (57) ovary, mated 4-day female  (54) testis, mated 4-day male    21 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    36 central nervous system, pupae P8    20 head, virgin 1-day female    18 head, virgin 4-day female    19 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    15 head, mated 1-day male    25 head, mated 4-day male    30 head, mated 20-day male    41 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    28 digestive system, 4-day adult    33 digestive system, 20-day adult    35 fat body, larvae L3 wandering    9 fat body, white prepupae    16 fat body, pupae P8    26 carcass, larvae L3 wandering    35 carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    14 ovary, virgin 4-day female    57 ovary, mated 4-day female    54 testis, mated 4-day male    21 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    36 central nervous system, pupae P8    20 head, virgin 1-day female    18 head, virgin 4-day female    19 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    15 head, mated 1-day male    25 head, mated 4-day male    30 head, mated 20-day male    41 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    28 digestive system, 4-day adult    33 digestive system, 20-day adult    35 fat body, larvae L3 wandering    9 fat body, white prepupae    16 fat body, pupae P8    26 carcass, larvae L3 wandering    35 carcass, 1-day adult    13 carcass, 4-day adult    15 carcass, 20-day adult    14 ovary, virgin 4-day female    57 ovary, mated 4-day female    54 testis, mated 4-day male    21 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    94 embryo 04-06hr    23 embryo 06-08hr    34 embryo 08-10hr    56 embryo 10-12hr    68 embryo 12-14hr    52 embryo 14-16hr    68 embryo 16-18hr    57 embryo 18-20hr    46 embryo 20-22hr    75 embryo 22-24hr    60 larva L1    39 larva L2    44 larva L3 12hr old    34 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    46 white prepupae new    46 white prepupae 12hr    40 white prepupae 24hr    41 pupae 2d postWPP    34 pupae 3d postWPP    26 pupae 4d postWPP    28 adult male 01day    32 adult male 05day    36 adult male 30day    38 adult female 01day    51 adult female 05day    64 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (97) embryo 02-04hr  (94) embryo 04-06hr    23 embryo 06-08hr  (34) embryo 08-10hr  (56) embryo 10-12hr  (68) embryo 12-14hr  (52) embryo 14-16hr  (68) embryo 16-18hr  (57) embryo 18-20hr  (46) embryo 20-22hr  (75) embryo 22-24hr  (60) larva L1  (39) larva L2  (44) larva L3 12hr old  (34) larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6  (41) larva L3 puffstage 7-9  (46) white prepupae new  (46) white prepupae 12hr  (40) white prepupae 24hr  (41) pupae 2d postWPP  (34) pupae 3d postWPP  26 pupae 4d postWPP  (28) adult male 01day  (32) adult male 05day  (36) adult male 30day  (38) adult female 01day  (51) adult female 05day  (64) adult female 30day  (66) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    94 embryo 04-06hr    23 embryo 06-08hr    34 embryo 08-10hr    56 embryo 10-12hr    68 embryo 12-14hr    52 embryo 14-16hr    68 embryo 16-18hr    57 embryo 18-20hr    46 embryo 20-22hr    75 embryo 22-24hr    60 larva L1    39 larva L2    44 larva L3 12hr old    34 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    46 white prepupae new    46 white prepupae 12hr    40 white prepupae 24hr    41 pupae 2d postWPP    34 pupae 3d postWPP    26 pupae 4d postWPP    28 adult male 01day    32 adult male 05day    36 adult male 30day    38 adult female 01day    51 adult female 05day    64 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    94 embryo 04-06hr    23 embryo 06-08hr    34 embryo 08-10hr    56 embryo 10-12hr    68 embryo 12-14hr    52 embryo 14-16hr    68 embryo 16-18hr    57 embryo 18-20hr    46 embryo 20-22hr    75 embryo 22-24hr    60 larva L1    39 larva L2    44 larva L3 12hr old    34 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    46 white prepupae new    46 white prepupae 12hr    40 white prepupae 24hr    41 pupae 2d postWPP    34 pupae 3d postWPP    26 pupae 4d postWPP    28 adult male 01day    32 adult male 05day    36 adult male 30day    38 adult female 01day    51 adult female 05day    64 adult female 30day    66 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    94 embryo 04-06hr    23 embryo 06-08hr    34 embryo 08-10hr    56 embryo 10-12hr    68 embryo 12-14hr    52 embryo 14-16hr    68 embryo 16-18hr    57 embryo 18-20hr    46 embryo 20-22hr    75 embryo 22-24hr    60 larva L1    39 larva L2    44 larva L3 12hr old    34 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    46 white prepupae new    46 white prepupae 12hr    40 white prepupae 24hr    41 pupae 2d postWPP    34 pupae 3d postWPP    26 pupae 4d postWPP    28 adult male 01day    32 adult male 05day    36 adult male 30day    38 adult female 01day    51 adult female 05day    64 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (97) embryo 02-04hr  (94) embryo 04-06hr    23 embryo 06-08hr  (34) embryo 08-10hr  (56) embryo 10-12hr  (68) embryo 12-14hr  (52) embryo 14-16hr  (68) embryo 16-18hr  (57) embryo 18-20hr  (46) embryo 20-22hr  (75) embryo 22-24hr  (60) larva L1  (39) larva L2  (44) larva L3 12hr old  (34) larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6  (41) larva L3 puffstage 7-9  (46) white prepupae new  (46) white prepupae 12hr  (40) white prepupae 24hr  (41) pupae 2d postWPP  (34) pupae 3d postWPP  26 pupae 4d postWPP  28 adult male 01day  32 adult male 05day  (36) adult male 30day  (38) adult female 01day  (51) adult female 05day  (64) adult female 30day  (66) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    94 embryo 04-06hr    23 embryo 06-08hr    34 embryo 08-10hr    56 embryo 10-12hr    68 embryo 12-14hr    52 embryo 14-16hr    68 embryo 16-18hr    57 embryo 18-20hr    46 embryo 20-22hr    75 embryo 22-24hr    60 larva L1    39 larva L2    44 larva L3 12hr old    34 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    46 white prepupae new    46 white prepupae 12hr    40 white prepupae 24hr    41 pupae 2d postWPP    34 pupae 3d postWPP    26 pupae 4d postWPP    28 adult male 01day    32 adult male 05day    36 adult male 30day    38 adult female 01day    51 adult female 05day    64 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    94 embryo 04-06hr    23 embryo 06-08hr    34 embryo 08-10hr    56 embryo 10-12hr    68 embryo 12-14hr    52 embryo 14-16hr    68 embryo 16-18hr    57 embryo 18-20hr    46 embryo 20-22hr    75 embryo 22-24hr    60 larva L1    39 larva L2    44 larva L3 12hr old    34 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    46 white prepupae new    46 white prepupae 12hr    40 white prepupae 24hr    41 pupae 2d postWPP    34 pupae 3d postWPP    26 pupae 4d postWPP    28 adult male 01day    32 adult male 05day    36 adult male 30day    38 adult female 01day    51 adult female 05day    64 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    103 Schneider line 2 Sg4    48 embryonic 1182-4H    58 embryonic GM2    55 embryonic Kc167    29 embryonic S1    70 embryonic S3    47 leg disc CME L1    66 wing disc CME-W2    26 wing disc ML-DmD8    34 wing disc ML-DmD9    49 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    43 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    50 antennal disc ML-DmD20-c5    49 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    70 CNS ML-DmBG2-c2    46 tumorous blood cells mbn2    46 ovary fGS/OSS    42 ovary OSC    26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (103) Schneider line 2 Sg4  (48) embryonic 1182-4H  (58) embryonic GM2  (55) embryonic Kc167  (29) embryonic S1  (70) embryonic S3  (47) leg disc CME L1  (66) wing disc CME-W2  26 wing disc ML-DmD8  (34) wing disc ML-DmD9  (49) wing disc ML-DmD16-c3  (52) wing disc ML-DmD21  (43) wing disc ML-DmD32  (42) haltere disc ML-DmD17-c3  (53) eye-antennal disc ML-DmD11  (50) antennal disc ML-DmD20-c5  (49) mixed discs ML-DmD4-c1  (46) CNS ML-DmBG1-c1  (70) CNS ML-DmBG2-c2  (46) tumorous blood cells mbn2  (46) ovary fGS/OSS  (42) ovary OSC  26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  103 Schneider line 2 Sg4    48 embryonic 1182-4H    58 embryonic GM2    55 embryonic Kc167    29 embryonic S1    70 embryonic S3    47 leg disc CME L1    66 wing disc CME-W2    26 wing disc ML-DmD8    34 wing disc ML-DmD9    49 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    43 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    50 antennal disc ML-DmD20-c5    49 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    70 CNS ML-DmBG2-c2    46 tumorous blood cells mbn2    46 ovary fGS/OSS    42 ovary OSC    26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    103 Schneider line 2 Sg4    48 embryonic 1182-4H    58 embryonic GM2    55 embryonic Kc167    29 embryonic S1    70 embryonic S3    47 leg disc CME L1    66 wing disc CME-W2    26 wing disc ML-DmD8    34 wing disc ML-DmD9    49 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    43 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    50 antennal disc ML-DmD20-c5    49 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    70 CNS ML-DmBG2-c2    46 tumorous blood cells mbn2    46 ovary fGS/OSS    42 ovary OSC    26 ovary OSS    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    103 Schneider line 2 Sg4    48 embryonic 1182-4H    58 embryonic GM2    55 embryonic Kc167    29 embryonic S1    70 embryonic S3    47 leg disc CME L1    66 wing disc CME-W2    26 wing disc ML-DmD8    34 wing disc ML-DmD9    49 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    43 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    50 antennal disc ML-DmD20-c5    49 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    70 CNS ML-DmBG2-c2    46 tumorous blood cells mbn2    46 ovary fGS/OSS    42 ovary OSC    26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (103) Schneider line 2 Sg4  (48) embryonic 1182-4H  (58) embryonic GM2  (55) embryonic Kc167  29 embryonic S1  (70) embryonic S3  (47) leg disc CME L1  (66) wing disc CME-W2  26 wing disc ML-DmD8  (34) wing disc ML-DmD9  (49) wing disc ML-DmD16-c3  (52) wing disc ML-DmD21  (43) wing disc ML-DmD32  (42) haltere disc ML-DmD17-c3  (53) eye-antennal disc ML-DmD11  (50) antennal disc ML-DmD20-c5  (49) mixed discs ML-DmD4-c1  (46) CNS ML-DmBG1-c1  (70) CNS ML-DmBG2-c2  (46) tumorous blood cells mbn2  (46) ovary fGS/OSS  (42) ovary OSC  26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  103 Schneider line 2 Sg4    48 embryonic 1182-4H    58 embryonic GM2    55 embryonic Kc167    29 embryonic S1    70 embryonic S3    47 leg disc CME L1    66 wing disc CME-W2    26 wing disc ML-DmD8    34 wing disc ML-DmD9    49 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    43 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    50 antennal disc ML-DmD20-c5    49 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    70 CNS ML-DmBG2-c2    46 tumorous blood cells mbn2    46 ovary fGS/OSS    42 ovary OSC    26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    103 Schneider line 2 Sg4    48 embryonic 1182-4H    58 embryonic GM2    55 embryonic Kc167    29 embryonic S1    70 embryonic S3    47 leg disc CME L1    66 wing disc CME-W2    26 wing disc ML-DmD8    34 wing disc ML-DmD9    49 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    43 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    50 antennal disc ML-DmD20-c5    49 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    70 CNS ML-DmBG2-c2    46 tumorous blood cells mbn2    46 ovary fGS/OSS    42 ovary OSC    26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    52 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    44 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    29 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult  (45) Cadmium 50 mM 6 hrs, larvae L3  (32) Cadmium 50 mM 12 hrs, larvae L3  26 Cadmium 50 mM 48 hrs, 4-day adult  (39) Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3  (52) Ethanol 5% 3 hrs, larvae L3  (27) Ethanol 10% 3 hrs, larvae L3  (35) Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (44) Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  (46) Rotenone 2 μg 12 hrs, larvae L3  (29) Rotenone 8 μg 12 hrs, larvae L3  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    52 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    44 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    29 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    52 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    44 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    29 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    52 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    44 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    29 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult  (45) Cadmium 50 mM 6 hrs, larvae L3  32 Cadmium 50 mM 12 hrs, larvae L3  26 Cadmium 50 mM 48 hrs, 4-day adult  (39) Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3  (52) Ethanol 5% 3 hrs, larvae L3  27 Ethanol 10% 3 hrs, larvae L3  (35) Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (44) Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  (46) Rotenone 2 μg 12 hrs, larvae L3  29 Rotenone 8 μg 12 hrs, larvae L3  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    52 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    44 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    29 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    18 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    52 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    44 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    29 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD31377 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024833 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9388-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage AP-1μSHE-11 lethal | first instar larval stage (with Df(3R)Exel6264) AP-1μSHE-11 lethal | pupal stage, with Scer\GAL4Act.PU AP-1μNIG.9388R partially lethal - majority die, with Scer\GAL4ey.PU AP-1μNIG.9388R viable, with Scer\GAL4pnr-MD237 AP-1μGD14206 viable (with AP-1μEP1112) AP-1μSHE-11 viable (with AP-1μSHE-11) AP-1μEP1112 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 AP-1μGD14206 Phenotype manifest in Allele embryonic/larval salivary gland | third instar larval stage, with Scer\GAL4AB1 AP-1μSHE-11 embryonic/larval salivary gland | third instar larval stage (with AP-1μEP1112) AP-1μSHE-11 embryonic/larval salivary gland | third instar larval stage (with AP-1μEP1112), with Scer\GAL4AB1 AP-1μSHE-11 embryonic/larval salivary gland | third instar larval stage (with AP-1μSHE-11) AP-1μEP1112 embryonic/larval salivary gland | third instar larval stage (with AP-1μSHE-11), with Scer\GAL4AB1 AP-1μEP1112 eye, with Scer\GAL4ey.PU AP-1μNIG.9388R eye | somatic clone AP-1μSHE-11 mesothoracic tergum, with Scer\GAL4pnr-MD237 AP-1μGD14206 ommatidium, with Scer\GAL4ey.PU AP-1μNIG.9388R secretory granule, with Scer\GAL4AB1 AP-1μSHE-11 secretory granule (with AP-1μEP1112) AP-1μSHE-11 secretory granule (with AP-1μSHE-11) AP-1μEP1112 tormogen cell | somatic clone | supernumerary AP-1μSHE-11 tormogen cell | supernumerary, with Scer\GAL4ap-md544 AP-1μGD14206
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of AP-1μ Class Mutagen Stocks Known lesion AP-1μSHE-11 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes AP-1μEP1112 P-element activity 1 -- AP-1μSAE-10 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes AP-1μEP3436 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of AP-1μ Class Mutagen Stocks Known lesion AP-1μGD14206 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AP-1μJF02685 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AP-1μNIG.9388R in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes AP-1μScer\UAS.T:Avic\GFP-YFP.Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6153 (Ryder, 2004.4.26) Df(3R)Exel6264 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}AP-1μEP1112 NA P{EP}AP-1μEP3436 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
protein transporter activity inferred from mutant phenotype (Kametaka et al., 2012)
Biological Process
CV term Evidence References
compound eye development inferred from mutant phenotype (Kametaka et al., 2012) intracellular transport inferred from mutant phenotype (Kametaka et al., 2012) negative regulation of endocytic recycling inferred from mutant phenotype (Benhra et al., 2011) negative regulation of Notch signaling pathway inferred from genetic interaction with Dl (Benhra et al., 2011) inferred from genetic interaction with Ser (Benhra et al., 2011) inferred from genetic interaction with spdo (Benhra et al., 2011) secretory granule organization inferred from mutant phenotype (Burgess et al., 2011)
Cellular Component
CV term Evidence References
AP1 complex inferred from mutant phenotype (Kametaka et al., 2012) inferred from physical interaction with AP-1γ (Kametaka et al., 2012) clathrin-coated vesicle inferred from direct assay (Hirst et al., 2009)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
intracellular protein transport inferred from electronic annotation with InterPro:IPR001392, InterPro:IPR008968, InterPro:IPR018240 (FlyBase Curators et al., 2004-) neurotransmitter secretion non-traceable author statement (Stimson and Ramaswami, 1999) synaptic vesicle coating traceable author statement (Stimson and Ramaswami, 1999) vesicle coating traceable author statement (Stimson and Ramaswami, 1999)
Cellular Component
CV term Evidence References
clathrin adaptor complex inferred from electronic annotation with InterPro:IPR001392, InterPro:IPR008968, InterPro:IPR018240 (FlyBase Curators et al., 2004-) coated vesicle traceable author statement (Stimson and Ramaswami, 1999) synaptic vesicle traceable author statement (Stimson and Ramaswami, 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
AP-1μ - AP-1γ anti tag coimmunoprecipitation, western blot (Kametaka et al., 2012) AP-1μ - Afti anti tag coimmunoprecipitation, western blot (Kametaka et al., 2012) AP-1μ - Aplip1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) AP-1μ - CG32512 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1μ - Gga anti tag coimmunoprecipitation, western blot (Kametaka et al., 2012) AP-1μ - Optix anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1μ - dome anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AP-1μ - vig anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions AP-1μ allele Gene References unspecified Psn (Mahoney et al., 2006)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0024833 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41150 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O62531
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6WSWWF Dipteran inclusive ortholog search EOG6J9N7D Insect inclusive ortholog search EOG6PG4WB Arthropod inclusive ortholog search EOG6ZS7JJ Metazoa inclusive ortholog search EOG6P8TBG
Orthologs in Drosophila Species (EOG6WSWWF)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\AP-1μ     Drosophila simulans   Dsim\GD20786 Y   Drosophila sechellia   Dsec\GM26246 Y   Drosophila erecta   Dere\GG17361 Y   Drosophila yakuba   Dyak\GE24766 Y   Drosophila ananassae   Dana\GF16536 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21750 Y   Drosophila persimilis   Dper\GL21499 Y   Drosophila willistoni   Dwil\GK11256 Y   Drosophila virilis   Dvir\GJ10271 Y   Drosophila mojavensis   Dmoj\GI23520 Y   Drosophila grimshawi   Dgri\AP-47 Y
Orthologs in non-Drosophila Dipterans (EOG6J9N7D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010704   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007124   Anopheles gambiae Malaria mosquito  Agam\AGAP011374   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018003
Orthologs in non-Dipteran Insects (EOG6PG4WB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC408391   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006078   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20125   Atta cephalotes Leafcutter ant  Acep\ACEP28021   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17106   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21001   Linepithema humile Argentine ant  Lhum\LH23877   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11618   Solenopsis invicta Red fire ant  Sinv\SINV23440   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009277   Pediculus humanus Human body louse  Phum\PHUM089270   Tribolium castaneum Red flour beetle  Tcas\TC001437
Orthologs in non-Insect Arthropods (EOG6ZS7JJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_222170   Ixodes scapularis Deer tick  Isca\ISCW021445
Orthologs in non-Arthropod Metazoa (EOG6P8TBG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\apm-1   Caenorhabditis elegans Nematode  Cele\unc-101   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004297gn   Danio rerio Zebrafish  Drer\ENSDARG00000039512   Danio rerio Zebrafish  Drer\ENSDARG00000089730   Danio rerio Zebrafish  Drer\ap1m2   Danio rerio Zebrafish  Drer\ENSDARG00000020838   Xenopus tropicalis Western clawed frog  Xtro\ap1m1   Xenopus tropicalis Western clawed frog  Xtro\ap1m2   Gallus gallus Domestic chicken  Ggal\AP1M1   Mus musculus House mouse  Mmus\ENSMUSG00000003309   Mus musculus House mouse  Mmus\Ap1m1   Rattus norvegicus Norway rat  Rnor\Ap1m1   Rattus norvegicus Norway rat  Rnor\RGD1561490   Homo sapiens Human  Hsap\AP1M1   Homo sapiens Human  Hsap\AP1M2
Human Orthologs (2)
Gene OMIM HGNC Hsap\AP1M1     Hsap\AP1M2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20786 Drosophila sechellia Dsec\GM26246 Drosophila erecta Dere\GG17361 Drosophila yakuba Dyak\GE24766 Drosophila ananassae Dana\GF16536 Drosophila pseudoobscura pseudoobscura Dpse\GA21750 Drosophila persimilis Dper\GL21499 Drosophila willistoni Dwil\GK11256 Drosophila virilis Dvir\GJ10271 Drosophila mojavensis Dmoj\GI23520 Drosophila grimshawi Dgri\AP-47
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	27534 y1 v1; P{TRiP.JF02685}attP2 8190 y1; sp1; Psn143 AP-1μSHE-11/TM6B, Tb1 16987 w1118; P{EP}AP-1μEP1112 MBD-likeEP1112/TM6B, Tb1 8189 y1 w1118; Psn9 AP-1μSAE-10 P{lacW}glB172/TM6B, Tb1
VDRC	v24017 w1118; P{GD14206}v24017/TM3
Genomic Clones ( 1 )
	BACR19N07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 186 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD27989 LD31377
Other clones	DPiM_LD31377
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT15015 GH28512 GM04713 GM19801 LD02875 LD03713 LD04934 LD05645 LD08023 LD08967 LD12568 LD12781 LD14447 LD14502 LD15945 LD25133 LD26856 LD27774 LD31965 LD34454 LD39168 LD41833 LD43182 LD43565 LD43858 LD45444 LD46777 LD46778 LD47932 LP02204 LP02228 RE04132 RE04206 RE05246 RE10216 RE19910 RE20111 RE29282 RE34173 RE37379 RE38438 RE40311 RE40323 RE44136 RE45524 RE56441 RE63380 RE69389 RE69757 RE74801 RH47549 RH60847 RH72105 SD03575 SD07954 SD11062 SD11168 SD24983
Other clones	EC33301 EK250625 EK272331 IP04632 RP003009748 RP003015755 RP003023492 RP003023572 RP003029994 RP003058070 RP003058970 RP003066469 RP003066593 RP003070946 RP003072636 RP003074246 RP003080013 RP003080173 RP003082457 RP003112855 RP003114290 RP003115834 RP003117587 RP003117900 RP003121085 RP003123480 RP003124630 RP003124964 RP003127020 RP003131733 RP003132544 RP003138468 RP003141456 RP003142838 RP003151140 RP003151198 RP003159183 RP003166152 RP003171254 RP003174260 RP003176822 RP003178229 RP003178736 RP003182871 RP003188388 RP003189787 RP003205729 RP003206028 RP003209006 RP003211120 RP003241270 RP003253679 RP003259725 RP003264964 RP003267388 RP003270871 RP003273296 RP003276758 RP003290250 RP003295968 RP003301002 RP003302659 RP003304616 RP003307840 RP003308261 RP003309691 RP003322649 RP003329010 RP003345781 RP003349067 RP003353322 RP003357864 RP003362634 RP003368827 RP003370490 RP003371983 RP003375698 RP003381446 RP003382665 RP003385507 RP003393145 RP003393330 RP003395614 RP003402863 RP003426741 RP003427735 RP003436768 RP003437991 RP003440797 RP003446593 RP003451450 RP003466329 RP003467049 RP003473012 RP003478004 RP003490806 RP003490926 RP003498665 RP003499036 RP003518154 RP003522680 RP003525616 RP003529554 RP003541811 RP003543697 RP003553554 RP003554418 RP003560580 RP003561033 RP003565404 RP003575956 RP003578883 RP003583015 RP003590908 RP003611874 RP003619870 RP003622019 RP003622280 RP003635264 RP003641957 RP003646478 RP003672151 RP003680705 SD27911 UUGC1108
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024833 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41150
Antibody Information
	polyclonal (Kametaka et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: AP-1μ AP-47 (Bonifacino et al., 2012.12.21)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141649 RefSeq (Proteins) • NP_649906 DDBJ / EMBL / GenBank • AA264458 AA439826 AA441214 AA951092 AAF14247 AAF54399 AAL13850 AF110231 AJ006219 AQ074009 AW943081 AY058621 CAA06918 Entrez Gene - A searchable database of RefSeq genes. • 41150 UniProtKB/TrEMBL • O62531
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Clathrin adaptor, mu subunit (IPR001392) Clathrin adaptor, mu subunit, C-terminal (IPR008968) Longin-like domain (IPR011012) Clathrin adaptor, mu subunit, conserved site (IPR018240) AP complex, mu/sigma subunit (IPR022775) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD31377
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0024833 DRSC - Results from RNAi screens. • FBgn0024833 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024833 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9388-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024833 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41150 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41150 modMine - Data generated by the modENCODE project. • FBgn0024833 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O62531
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	AP-1μ (Bonifacino et al., 2012.12.21) AP-1μ1 (Hirst et al., 2009, Benhra et al., 2011, Burgess et al., 2011) AP1μ1 (Kametaka et al., 2012) AP47 (Bellen, 2000.12.25, Zhang, 1998.5.14, Zhang and Broadie, 1999, Kametaka et al., 2010, Peng et al., 2009, Peng et al., 2009, Yang et al., 2011, Kametaka et al., 2012) AP-47 (Burgess et al., 2011, Mahoney et al., 2006, Benhra et al., 2011) apm1 (Neumann et al., 2010, Neumann et al., 2010) APμ1 (Kametaka et al., 2012) cg9388 (Boehm and Bonifacino, 2002) CG9388 (Boehm, 2001, Verstreken and Bellen, 2000.9.4, Perkins et al., 2009, Benhra et al., 2011) Dμ1 (Jullien-Flores et al., 2000) μ1 (Boehm and Bonifacino, 2001, Mullins et al., 1999, Kametaka et al., 2012)
Name Synonym	Adaptor Protein complex 1, μ subunit (Bonifacino et al., 2012.12.21, ) AP-47
Secondary FlyBase IDs
References ( 41 )
Generate a list of	All references relating to this gene ( 41 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 8 ) Review  ( 2 ) Personal communication to FlyBase  ( 11 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 1 ) Letter  ( 1 )
Recent research papers ( 4 )
	Kametaka et al., 2012, J. Cell Sci. 125(3): 634--648 AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. [FBrf0217589] Benhra et al., 2011, Curr. Biol. 21(1): 87--95 AP-1 Controls the Trafficking of Notch and Sanpodo toward E-Cadherin Junctions in Sensory Organ Precursors. [FBrf0212697] Burgess et al., 2011, Mol. Biol. Cell 22(12): 2094--2105 AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila. [FBrf0213890] Yang et al., 2011, Neuron 72(2): 285--299 Nak regulates localization of clathrin sites in higher-order dendrites to promote local dendrite growth. [FBrf0216477] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...