General Information Symbol Dmel\ TrnSpecies D. melanogaster Name Transportin Annotation symbol CG7398 Feature type protein_coding_gene FlyBase ID FBgn0024921 Gene Model Status Current Stock availability 6 publicly
available Also Known As dTRN Genomic Location Chromosome (arm) 3L Recombination map Cytogenetic map 65A8-65A8 Sequence location 3L:6,186,580..6,193,485 [+]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information The gene
Transportin is referred to in FlyBase by the symbol
Dmel\Trn (CG7398, FBgn0024921). It is a protein_coding_gene from
Drosophila melanogaster . Based on sequence similarity, it is predicted to have
molecular function : protein transmembrane transporter activity. There is experimental evidence that it is involved in the
biological process : neurogenesis; phagocytosis, engulfment.
6 alleles are reported . The
phenotype of these alleles is annotated with: mesothoracic tergum. It has
4 annotated transcripts and
4 annotated polypeptides .
Protein features are: Armadillo-like helical; Armadillo-type fold; HEAT; Importin-beta, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult hindgut, larval Malpighian tubules, larval salivary gland, adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624080_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Trn. Gene sequence location is
3L:6186580..6193485 .
User Contributed Data
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript Expression
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
720.775
Larval Midgut
357.1
Larval Hindgut
515.9
Larval Malpighian Tubules
725.1
Larval Fat Body
302.3
Larval Salivary Gland
883.8
Larval Trachea
443.25
Larval Carcass
545.85
Adult Head
407.4
Adult Eye
293.75
Adult Brain
760.4
Adult Thoracic-Abdominal Ganglion
635.7
Adult Crop
540.6
Adult Midgut
386.9
Adult Hindgut
570.2
Adult Malpighian Tubules
412.2
Adult Fat Body
449.6
Adult Salivary Gland
279.5
Adult Heart
408.95
Adult VirginFemale Spermatheca
325.9
Adult InseminatedFemale Spermatheca
348.4
Adult Ovary
961.9
Adult Testis
106.5
Adult Male Accessory Gland
398.2
Adult Carcass
303.8
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
(720.775)
Larval Midgut
357.1
Larval Hindgut
515.9
Larval Malpighian Tubules
(725.1)
Larval Fat Body
302.3
Larval Salivary Gland
(883.8)
Larval Trachea
443.25
Larval Carcass
(545.85)
Adult Head
407.4
Adult Eye
293.75
Adult Brain
(760.4)
Adult Thoracic-Abdominal Ganglion
(635.7)
Adult Crop
(540.6)
Adult Midgut
386.9
Adult Hindgut
(570.2)
Adult Malpighian Tubules
412.2
Adult Fat Body
449.6
Adult Salivary Gland
279.5
Adult Heart
408.95
Adult VirginFemale Spermatheca
325.9
Adult InseminatedFemale Spermatheca
348.4
Adult Ovary
(961.9)
Adult Testis
106.5
Adult Male Accessory Gland
398.2
Adult Carcass
303.8
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
720.775
Larval Midgut
357.1
Larval Hindgut
515.9
Larval Malpighian Tubules
725.1
Larval Fat Body
302.3
Larval Salivary Gland
883.8
Larval Trachea
443.25
Larval Carcass
545.85
Adult Head
407.4
Adult Eye
293.75
Adult Brain
760.4
Adult Thoracic-Abdominal Ganglion
635.7
Adult Crop
540.6
Adult Midgut
386.9
Adult Hindgut
570.2
Adult Malpighian Tubules
412.2
Adult Fat Body
449.6
Adult Salivary Gland
279.5
Adult Heart
408.95
Adult VirginFemale Spermatheca
325.9
Adult InseminatedFemale Spermatheca
348.4
Adult Ovary
961.9
Adult Testis
106.5
Adult Male Accessory Gland
398.2
Adult Carcass
303.8
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
720.775
Larval Midgut
357.1
Larval Hindgut
515.9
Larval Malpighian Tubules
725.1
Larval Fat Body
302.3
Larval Salivary Gland
883.8
Larval Trachea
443.25
Larval Carcass
545.85
Adult Head
407.4
Adult Eye
293.75
Adult Brain
760.4
Adult Thoracic-Abdominal Ganglion
635.7
Adult Crop
540.6
Adult Midgut
386.9
Adult Hindgut
570.2
Adult Malpighian Tubules
412.2
Adult Fat Body
449.6
Adult Salivary Gland
279.5
Adult Heart
408.95
Adult VirginFemale Spermatheca
325.9
Adult InseminatedFemale Spermatheca
348.4
Adult Ovary
961.9
Adult Testis
106.5
Adult Male Accessory Gland
398.2
Adult Carcass
303.8
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
720.775
Larval Midgut
357.1
Larval Hindgut
515.9
Larval Malpighian Tubules
725.1
Larval Fat Body
302.3
Larval Salivary Gland
883.8
Larval Trachea
443.25
Larval Carcass
545.85
Adult Head
407.4
Adult Eye
293.75
Adult Brain
760.4
Adult Thoracic-Abdominal Ganglion
635.7
Adult Crop
540.6
Adult Midgut
386.9
Adult Hindgut
570.2
Adult Malpighian Tubules
412.2
Adult Fat Body
449.6
Adult Salivary Gland
279.5
Adult Heart
408.95
Adult VirginFemale Spermatheca
325.9
Adult InseminatedFemale Spermatheca
348.4
Adult Ovary
961.9
Adult Testis
106.5
Adult Male Accessory Gland
398.2
Adult Carcass
303.8
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
720.775
Larval Midgut
357.1
Larval Hindgut
515.9
Larval Malpighian Tubules
725.1
Larval Fat Body
302.3
Larval Salivary Gland
(883.8)
Larval Trachea
443.25
Larval Carcass
545.85
Adult Head
407.4
Adult Eye
293.75
Adult Brain
760.4
Adult Thoracic-Abdominal Ganglion
635.7
Adult Crop
540.6
Adult Midgut
386.9
Adult Hindgut
570.2
Adult Malpighian Tubules
412.2
Adult Fat Body
449.6
Adult Salivary Gland
279.5
Adult Heart
408.95
Adult VirginFemale Spermatheca
325.9
Adult InseminatedFemale Spermatheca
348.4
Adult Ovary
(961.9)
Adult Testis
106.5
Adult Male Accessory Gland
398.2
Adult Carcass
303.8
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
720.775
Larval Midgut
357.1
Larval Hindgut
515.9
Larval Malpighian Tubules
725.1
Larval Fat Body
302.3
Larval Salivary Gland
883.8
Larval Trachea
443.25
Larval Carcass
545.85
Adult Head
407.4
Adult Eye
293.75
Adult Brain
760.4
Adult Thoracic-Abdominal Ganglion
635.7
Adult Crop
540.6
Adult Midgut
386.9
Adult Hindgut
570.2
Adult Malpighian Tubules
412.2
Adult Fat Body
449.6
Adult Salivary Gland
279.5
Adult Heart
408.95
Adult VirginFemale Spermatheca
325.9
Adult InseminatedFemale Spermatheca
348.4
Adult Ovary
961.9
Adult Testis
106.5
Adult Male Accessory Gland
398.2
Adult Carcass
303.8
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
720.775
Larval Midgut
357.1
Larval Hindgut
515.9
Larval Malpighian Tubules
725.1
Larval Fat Body
302.3
Larval Salivary Gland
883.8
Larval Trachea
443.25
Larval Carcass
545.85
Adult Head
407.4
Adult Eye
293.75
Adult Brain
760.4
Adult Thoracic-Abdominal Ganglion
635.7
Adult Crop
540.6
Adult Midgut
386.9
Adult Hindgut
570.2
Adult Malpighian Tubules
412.2
Adult Fat Body
449.6
Adult Salivary Gland
279.5
Adult Heart
408.95
Adult VirginFemale Spermatheca
325.9
Adult InseminatedFemale Spermatheca
348.4
Adult Ovary
961.9
Adult Testis
106.5
Adult Male Accessory Gland
398.2
Adult Carcass
303.8
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
407.4
NA
Eye
293.75
NA
Brain
760.4
720.775
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
635.7
NA
Crop
540.6
357.1
Midgut
386.9
515.9
Hindgut
570.2
725.1
Malpighian Tubules
412.2
302.3
Fat Body
449.6
883.8
Salivary Gland
279.5
NA
Heart
408.95
443.25
Trachea
NA
NA
VirginFemale Spermatheca
325.9
NA
InseminatedFemale Spermatheca
348.4
NA
Ovary
961.9
NA
Testis
106.5
NA
Male Accessory Gland
398.2
545.85
Carcass
303.8
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
37
central nervous system, pupae P8
25
head, virgin 1-day female
17
head, virgin 4-day female
14
head, virgin 20-day female
12
head, mated 1-day female
12
head, mated 4-day female
12
head, mated 20-day female
12
head, mated 1-day male
19
head, mated 4-day male
20
head, mated 20-day male
22
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
23
digestive system, larvae L3 wandering
18
digestive system, 1-day adult
8
digestive system, 4-day adult
13
digestive system, 20-day adult
10
fat body, larvae L3 wandering
4
fat body, white prepupae
13
fat body, pupae P8
10
carcass, larvae L3 wandering
30
carcass, 1-day adult
12
carcass, 4-day adult
13
carcass, 20-day adult
11
ovary, virgin 4-day female
98
ovary, mated 4-day female
80
testis, mated 4-day male
6
accessory gland, mated 4-day male
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
(37)
central nervous system, pupae P8
25
head, virgin 1-day female
17
head, virgin 4-day female
14
head, virgin 20-day female
12
head, mated 1-day female
12
head, mated 4-day female
12
head, mated 20-day female
12
head, mated 1-day male
19
head, mated 4-day male
20
head, mated 20-day male
22
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
23
digestive system, larvae L3 wandering
18
digestive system, 1-day adult
8
digestive system, 4-day adult
13
digestive system, 20-day adult
10
fat body, larvae L3 wandering
4
fat body, white prepupae
13
fat body, pupae P8
10
carcass, larvae L3 wandering
(30)
carcass, 1-day adult
12
carcass, 4-day adult
13
carcass, 20-day adult
11
ovary, virgin 4-day female
(98)
ovary, mated 4-day female
(80)
testis, mated 4-day male
6
accessory gland, mated 4-day male
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
37
central nervous system, pupae P8
25
head, virgin 1-day female
17
head, virgin 4-day female
14
head, virgin 20-day female
12
head, mated 1-day female
12
head, mated 4-day female
12
head, mated 20-day female
12
head, mated 1-day male
19
head, mated 4-day male
20
head, mated 20-day male
22
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
23
digestive system, larvae L3 wandering
18
digestive system, 1-day adult
8
digestive system, 4-day adult
13
digestive system, 20-day adult
10
fat body, larvae L3 wandering
4
fat body, white prepupae
13
fat body, pupae P8
10
carcass, larvae L3 wandering
30
carcass, 1-day adult
12
carcass, 4-day adult
13
carcass, 20-day adult
11
ovary, virgin 4-day female
98
ovary, mated 4-day female
80
testis, mated 4-day male
6
accessory gland, mated 4-day male
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
37
central nervous system, pupae P8
25
head, virgin 1-day female
17
head, virgin 4-day female
14
head, virgin 20-day female
12
head, mated 1-day female
12
head, mated 4-day female
12
head, mated 20-day female
12
head, mated 1-day male
19
head, mated 4-day male
20
head, mated 20-day male
22
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
23
digestive system, larvae L3 wandering
18
digestive system, 1-day adult
8
digestive system, 4-day adult
13
digestive system, 20-day adult
10
fat body, larvae L3 wandering
4
fat body, white prepupae
13
fat body, pupae P8
10
carcass, larvae L3 wandering
30
carcass, 1-day adult
12
carcass, 4-day adult
13
carcass, 20-day adult
11
ovary, virgin 4-day female
98
ovary, mated 4-day female
80
testis, mated 4-day male
6
accessory gland, mated 4-day male
4
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
37
central nervous system, pupae P8
25
head, virgin 1-day female
17
head, virgin 4-day female
14
head, virgin 20-day female
12
head, mated 1-day female
12
head, mated 4-day female
12
head, mated 20-day female
12
head, mated 1-day male
19
head, mated 4-day male
20
head, mated 20-day male
22
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
23
digestive system, larvae L3 wandering
18
digestive system, 1-day adult
8
digestive system, 4-day adult
13
digestive system, 20-day adult
10
fat body, larvae L3 wandering
4
fat body, white prepupae
13
fat body, pupae P8
10
carcass, larvae L3 wandering
30
carcass, 1-day adult
12
carcass, 4-day adult
13
carcass, 20-day adult
11
ovary, virgin 4-day female
98
ovary, mated 4-day female
80
testis, mated 4-day male
6
accessory gland, mated 4-day male
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
(37)
central nervous system, pupae P8
25
head, virgin 1-day female
17
head, virgin 4-day female
14
head, virgin 20-day female
12
head, mated 1-day female
12
head, mated 4-day female
12
head, mated 20-day female
12
head, mated 1-day male
19
head, mated 4-day male
20
head, mated 20-day male
22
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
23
digestive system, larvae L3 wandering
18
digestive system, 1-day adult
8
digestive system, 4-day adult
13
digestive system, 20-day adult
10
fat body, larvae L3 wandering
4
fat body, white prepupae
13
fat body, pupae P8
10
carcass, larvae L3 wandering
30
carcass, 1-day adult
12
carcass, 4-day adult
13
carcass, 20-day adult
11
ovary, virgin 4-day female
(98)
ovary, mated 4-day female
(80)
testis, mated 4-day male
6
accessory gland, mated 4-day male
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
37
central nervous system, pupae P8
25
head, virgin 1-day female
17
head, virgin 4-day female
14
head, virgin 20-day female
12
head, mated 1-day female
12
head, mated 4-day female
12
head, mated 20-day female
12
head, mated 1-day male
19
head, mated 4-day male
20
head, mated 20-day male
22
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
23
digestive system, larvae L3 wandering
18
digestive system, 1-day adult
8
digestive system, 4-day adult
13
digestive system, 20-day adult
10
fat body, larvae L3 wandering
4
fat body, white prepupae
13
fat body, pupae P8
10
carcass, larvae L3 wandering
30
carcass, 1-day adult
12
carcass, 4-day adult
13
carcass, 20-day adult
11
ovary, virgin 4-day female
98
ovary, mated 4-day female
80
testis, mated 4-day male
6
accessory gland, mated 4-day male
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
37
central nervous system, pupae P8
25
head, virgin 1-day female
17
head, virgin 4-day female
14
head, virgin 20-day female
12
head, mated 1-day female
12
head, mated 4-day female
12
head, mated 20-day female
12
head, mated 1-day male
19
head, mated 4-day male
20
head, mated 20-day male
22
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
23
digestive system, larvae L3 wandering
18
digestive system, 1-day adult
8
digestive system, 4-day adult
13
digestive system, 20-day adult
10
fat body, larvae L3 wandering
4
fat body, white prepupae
13
fat body, pupae P8
10
carcass, larvae L3 wandering
30
carcass, 1-day adult
12
carcass, 4-day adult
13
carcass, 20-day adult
11
ovary, virgin 4-day female
98
ovary, mated 4-day female
80
testis, mated 4-day male
6
accessory gland, mated 4-day male
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
70
embryo 02-04hr
79
embryo 04-06hr
30
embryo 06-08hr
27
embryo 08-10hr
39
embryo 10-12hr
24
embryo 12-14hr
29
embryo 14-16hr
24
embryo 16-18hr
25
embryo 18-20hr
14
embryo 20-22hr
17
embryo 22-24hr
24
larva L1
12
larva L2
11
larva L3 12hr old
9
larva L3 puffstage 1-2
5
larva L3 puffstage 3-6
16
larva L3 puffstage 7-9
27
white prepupae new
31
white prepupae 12hr
27
white prepupae 24hr
21
pupae 2d postWPP
17
pupae 3d postWPP
12
pupae 4d postWPP
9
adult male 01day
11
adult male 05day
11
adult male 30day
9
adult female 01day
25
adult female 05day
49
adult female 30day
44
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(70)
embryo 02-04hr
(79)
embryo 04-06hr
(30)
embryo 06-08hr
(27)
embryo 08-10hr
(39)
embryo 10-12hr
24
embryo 12-14hr
(29)
embryo 14-16hr
24
embryo 16-18hr
25
embryo 18-20hr
14
embryo 20-22hr
17
embryo 22-24hr
24
larva L1
12
larva L2
11
larva L3 12hr old
9
larva L3 puffstage 1-2
5
larva L3 puffstage 3-6
16
larva L3 puffstage 7-9
(27)
white prepupae new
(31)
white prepupae 12hr
(27)
white prepupae 24hr
21
pupae 2d postWPP
17
pupae 3d postWPP
12
pupae 4d postWPP
9
adult male 01day
11
adult male 05day
11
adult male 30day
9
adult female 01day
25
adult female 05day
(49)
adult female 30day
(44)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
70
embryo 02-04hr
79
embryo 04-06hr
30
embryo 06-08hr
27
embryo 08-10hr
39
embryo 10-12hr
24
embryo 12-14hr
29
embryo 14-16hr
24
embryo 16-18hr
25
embryo 18-20hr
14
embryo 20-22hr
17
embryo 22-24hr
24
larva L1
12
larva L2
11
larva L3 12hr old
9
larva L3 puffstage 1-2
5
larva L3 puffstage 3-6
16
larva L3 puffstage 7-9
27
white prepupae new
31
white prepupae 12hr
27
white prepupae 24hr
21
pupae 2d postWPP
17
pupae 3d postWPP
12
pupae 4d postWPP
9
adult male 01day
11
adult male 05day
11
adult male 30day
9
adult female 01day
25
adult female 05day
49
adult female 30day
44
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
70
embryo 02-04hr
79
embryo 04-06hr
30
embryo 06-08hr
27
embryo 08-10hr
39
embryo 10-12hr
24
embryo 12-14hr
29
embryo 14-16hr
24
embryo 16-18hr
25
embryo 18-20hr
14
embryo 20-22hr
17
embryo 22-24hr
24
larva L1
12
larva L2
11
larva L3 12hr old
9
larva L3 puffstage 1-2
5
larva L3 puffstage 3-6
16
larva L3 puffstage 7-9
27
white prepupae new
31
white prepupae 12hr
27
white prepupae 24hr
21
pupae 2d postWPP
17
pupae 3d postWPP
12
pupae 4d postWPP
9
adult male 01day
11
adult male 05day
11
adult male 30day
9
adult female 01day
25
adult female 05day
49
adult female 30day
44
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
70
embryo 02-04hr
79
embryo 04-06hr
30
embryo 06-08hr
27
embryo 08-10hr
39
embryo 10-12hr
24
embryo 12-14hr
29
embryo 14-16hr
24
embryo 16-18hr
25
embryo 18-20hr
14
embryo 20-22hr
17
embryo 22-24hr
24
larva L1
12
larva L2
11
larva L3 12hr old
9
larva L3 puffstage 1-2
5
larva L3 puffstage 3-6
16
larva L3 puffstage 7-9
27
white prepupae new
31
white prepupae 12hr
27
white prepupae 24hr
21
pupae 2d postWPP
17
pupae 3d postWPP
12
pupae 4d postWPP
9
adult male 01day
11
adult male 05day
11
adult male 30day
9
adult female 01day
25
adult female 05day
49
adult female 30day
44
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(70)
embryo 02-04hr
(79)
embryo 04-06hr
30
embryo 06-08hr
27
embryo 08-10hr
(39)
embryo 10-12hr
24
embryo 12-14hr
29
embryo 14-16hr
24
embryo 16-18hr
25
embryo 18-20hr
14
embryo 20-22hr
17
embryo 22-24hr
24
larva L1
12
larva L2
11
larva L3 12hr old
9
larva L3 puffstage 1-2
5
larva L3 puffstage 3-6
16
larva L3 puffstage 7-9
27
white prepupae new
31
white prepupae 12hr
27
white prepupae 24hr
21
pupae 2d postWPP
17
pupae 3d postWPP
12
pupae 4d postWPP
9
adult male 01day
11
adult male 05day
11
adult male 30day
9
adult female 01day
25
adult female 05day
(49)
adult female 30day
(44)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
70
embryo 02-04hr
79
embryo 04-06hr
30
embryo 06-08hr
27
embryo 08-10hr
39
embryo 10-12hr
24
embryo 12-14hr
29
embryo 14-16hr
24
embryo 16-18hr
25
embryo 18-20hr
14
embryo 20-22hr
17
embryo 22-24hr
24
larva L1
12
larva L2
11
larva L3 12hr old
9
larva L3 puffstage 1-2
5
larva L3 puffstage 3-6
16
larva L3 puffstage 7-9
27
white prepupae new
31
white prepupae 12hr
27
white prepupae 24hr
21
pupae 2d postWPP
17
pupae 3d postWPP
12
pupae 4d postWPP
9
adult male 01day
11
adult male 05day
11
adult male 30day
9
adult female 01day
25
adult female 05day
49
adult female 30day
44
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
70
embryo 02-04hr
79
embryo 04-06hr
30
embryo 06-08hr
27
embryo 08-10hr
39
embryo 10-12hr
24
embryo 12-14hr
29
embryo 14-16hr
24
embryo 16-18hr
25
embryo 18-20hr
14
embryo 20-22hr
17
embryo 22-24hr
24
larva L1
12
larva L2
11
larva L3 12hr old
9
larva L3 puffstage 1-2
5
larva L3 puffstage 3-6
16
larva L3 puffstage 7-9
27
white prepupae new
31
white prepupae 12hr
27
white prepupae 24hr
21
pupae 2d postWPP
17
pupae 3d postWPP
12
pupae 4d postWPP
9
adult male 01day
11
adult male 05day
11
adult male 30day
9
adult female 01day
25
adult female 05day
49
adult female 30day
44
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
28
Schneider line 2 Sg4
18
embryonic 1182-4H
27
embryonic GM2
37
embryonic Kc167
28
embryonic S1
27
embryonic S3
29
leg disc CME L1
18
wing disc CME-W2
31
wing disc ML-DmD8
21
wing disc ML-DmD9
24
wing disc ML-DmD16-c3
23
wing disc ML-DmD21
4
wing disc ML-DmD32
12
haltere disc ML-DmD17-c3
32
eye-antennal disc ML-DmD11
17
antennal disc ML-DmD20-c5
11
mixed discs ML-DmD4-c1
15
CNS ML-DmBG1-c1
18
CNS ML-DmBG2-c2
23
tumorous blood cells mbn2
31
ovary fGS/OSS
18
ovary OSC
23
ovary OSS
15
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(28)
Schneider line 2 Sg4
18
embryonic 1182-4H
(27)
embryonic GM2
(37)
embryonic Kc167
(28)
embryonic S1
(27)
embryonic S3
(29)
leg disc CME L1
18
wing disc CME-W2
(31)
wing disc ML-DmD8
21
wing disc ML-DmD9
24
wing disc ML-DmD16-c3
23
wing disc ML-DmD21
4
wing disc ML-DmD32
12
haltere disc ML-DmD17-c3
(32)
eye-antennal disc ML-DmD11
17
antennal disc ML-DmD20-c5
11
mixed discs ML-DmD4-c1
15
CNS ML-DmBG1-c1
18
CNS ML-DmBG2-c2
23
tumorous blood cells mbn2
(31)
ovary fGS/OSS
18
ovary OSC
23
ovary OSS
15
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
28
Schneider line 2 Sg4
18
embryonic 1182-4H
27
embryonic GM2
37
embryonic Kc167
28
embryonic S1
27
embryonic S3
29
leg disc CME L1
18
wing disc CME-W2
31
wing disc ML-DmD8
21
wing disc ML-DmD9
24
wing disc ML-DmD16-c3
23
wing disc ML-DmD21
4
wing disc ML-DmD32
12
haltere disc ML-DmD17-c3
32
eye-antennal disc ML-DmD11
17
antennal disc ML-DmD20-c5
11
mixed discs ML-DmD4-c1
15
CNS ML-DmBG1-c1
18
CNS ML-DmBG2-c2
23
tumorous blood cells mbn2
31
ovary fGS/OSS
18
ovary OSC
23
ovary OSS
15
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
28
Schneider line 2 Sg4
18
embryonic 1182-4H
27
embryonic GM2
37
embryonic Kc167
28
embryonic S1
27
embryonic S3
29
leg disc CME L1
18
wing disc CME-W2
31
wing disc ML-DmD8
21
wing disc ML-DmD9
24
wing disc ML-DmD16-c3
23
wing disc ML-DmD21
4
wing disc ML-DmD32
12
haltere disc ML-DmD17-c3
32
eye-antennal disc ML-DmD11
17
antennal disc ML-DmD20-c5
11
mixed discs ML-DmD4-c1
15
CNS ML-DmBG1-c1
18
CNS ML-DmBG2-c2
23
tumorous blood cells mbn2
31
ovary fGS/OSS
18
ovary OSC
23
ovary OSS
15
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
28
Schneider line 2 Sg4
18
embryonic 1182-4H
27
embryonic GM2
37
embryonic Kc167
28
embryonic S1
27
embryonic S3
29
leg disc CME L1
18
wing disc CME-W2
31
wing disc ML-DmD8
21
wing disc ML-DmD9
24
wing disc ML-DmD16-c3
23
wing disc ML-DmD21
4
wing disc ML-DmD32
12
haltere disc ML-DmD17-c3
32
eye-antennal disc ML-DmD11
17
antennal disc ML-DmD20-c5
11
mixed discs ML-DmD4-c1
15
CNS ML-DmBG1-c1
18
CNS ML-DmBG2-c2
23
tumorous blood cells mbn2
31
ovary fGS/OSS
18
ovary OSC
23
ovary OSS
15
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
28
Schneider line 2 Sg4
18
embryonic 1182-4H
27
embryonic GM2
(37)
embryonic Kc167
28
embryonic S1
27
embryonic S3
29
leg disc CME L1
18
wing disc CME-W2
31
wing disc ML-DmD8
21
wing disc ML-DmD9
24
wing disc ML-DmD16-c3
23
wing disc ML-DmD21
4
wing disc ML-DmD32
12
haltere disc ML-DmD17-c3
32
eye-antennal disc ML-DmD11
17
antennal disc ML-DmD20-c5
11
mixed discs ML-DmD4-c1
15
CNS ML-DmBG1-c1
18
CNS ML-DmBG2-c2
23
tumorous blood cells mbn2
31
ovary fGS/OSS
18
ovary OSC
23
ovary OSS
15
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
28
Schneider line 2 Sg4
18
embryonic 1182-4H
27
embryonic GM2
37
embryonic Kc167
28
embryonic S1
27
embryonic S3
29
leg disc CME L1
18
wing disc CME-W2
31
wing disc ML-DmD8
21
wing disc ML-DmD9
24
wing disc ML-DmD16-c3
23
wing disc ML-DmD21
4
wing disc ML-DmD32
12
haltere disc ML-DmD17-c3
32
eye-antennal disc ML-DmD11
17
antennal disc ML-DmD20-c5
11
mixed discs ML-DmD4-c1
15
CNS ML-DmBG1-c1
18
CNS ML-DmBG2-c2
23
tumorous blood cells mbn2
31
ovary fGS/OSS
18
ovary OSC
23
ovary OSS
15
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
28
Schneider line 2 Sg4
18
embryonic 1182-4H
27
embryonic GM2
37
embryonic Kc167
28
embryonic S1
27
embryonic S3
29
leg disc CME L1
18
wing disc CME-W2
31
wing disc ML-DmD8
21
wing disc ML-DmD9
24
wing disc ML-DmD16-c3
23
wing disc ML-DmD21
4
wing disc ML-DmD32
12
haltere disc ML-DmD17-c3
32
eye-antennal disc ML-DmD11
17
antennal disc ML-DmD20-c5
11
mixed discs ML-DmD4-c1
15
CNS ML-DmBG1-c1
18
CNS ML-DmBG2-c2
23
tumorous blood cells mbn2
31
ovary fGS/OSS
18
ovary OSC
23
ovary OSS
15
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
14
heat shock, 4-day adult
27
Cadmium 50 mM 6 hrs, larvae L3
8
Cadmium 50 mM 12 hrs, larvae L3
12
Cadmium 50 mM 48 hrs, 4-day adult
26
Cadmium 100 mM 48 hrs, 4-day adult
60
Copper 0.5 mM 12 hrs, larvae L3
6
Copper 15 mM 48 hrs, 4-day adult
45
Zinc 5 mM 12 hrs, larvae L3
5
Zinc 4.5 mM 48 hrs, 4-day adult
20
Ethanol 2.5% 3 hrs, larvae L3
54
Ethanol 5% 3 hrs, larvae L3
10
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
48
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
40
Paraquat 10 mM 48 hrs, 4-day adult
38
Rotenone 2 μg 12 hrs, larvae L3
10
Rotenone 8 μg 12 hrs, larvae L3
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
14
heat shock, 4-day adult
(27)
Cadmium 50 mM 6 hrs, larvae L3
8
Cadmium 50 mM 12 hrs, larvae L3
12
Cadmium 50 mM 48 hrs, 4-day adult
26
Cadmium 100 mM 48 hrs, 4-day adult
(60)
Copper 0.5 mM 12 hrs, larvae L3
6
Copper 15 mM 48 hrs, 4-day adult
(45)
Zinc 5 mM 12 hrs, larvae L3
5
Zinc 4.5 mM 48 hrs, 4-day adult
20
Ethanol 2.5% 3 hrs, larvae L3
(54)
Ethanol 5% 3 hrs, larvae L3
10
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(48)
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
(40)
Paraquat 10 mM 48 hrs, 4-day adult
(38)
Rotenone 2 μg 12 hrs, larvae L3
10
Rotenone 8 μg 12 hrs, larvae L3
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
14
heat shock, 4-day adult
27
Cadmium 50 mM 6 hrs, larvae L3
8
Cadmium 50 mM 12 hrs, larvae L3
12
Cadmium 50 mM 48 hrs, 4-day adult
26
Cadmium 100 mM 48 hrs, 4-day adult
60
Copper 0.5 mM 12 hrs, larvae L3
6
Copper 15 mM 48 hrs, 4-day adult
45
Zinc 5 mM 12 hrs, larvae L3
5
Zinc 4.5 mM 48 hrs, 4-day adult
20
Ethanol 2.5% 3 hrs, larvae L3
54
Ethanol 5% 3 hrs, larvae L3
10
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
48
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
40
Paraquat 10 mM 48 hrs, 4-day adult
38
Rotenone 2 μg 12 hrs, larvae L3
10
Rotenone 8 μg 12 hrs, larvae L3
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
14
heat shock, 4-day adult
27
Cadmium 50 mM 6 hrs, larvae L3
8
Cadmium 50 mM 12 hrs, larvae L3
12
Cadmium 50 mM 48 hrs, 4-day adult
26
Cadmium 100 mM 48 hrs, 4-day adult
60
Copper 0.5 mM 12 hrs, larvae L3
6
Copper 15 mM 48 hrs, 4-day adult
45
Zinc 5 mM 12 hrs, larvae L3
5
Zinc 4.5 mM 48 hrs, 4-day adult
20
Ethanol 2.5% 3 hrs, larvae L3
54
Ethanol 5% 3 hrs, larvae L3
10
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
48
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
40
Paraquat 10 mM 48 hrs, 4-day adult
38
Rotenone 2 μg 12 hrs, larvae L3
10
Rotenone 8 μg 12 hrs, larvae L3
5
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
14
heat shock, 4-day adult
27
Cadmium 50 mM 6 hrs, larvae L3
8
Cadmium 50 mM 12 hrs, larvae L3
12
Cadmium 50 mM 48 hrs, 4-day adult
26
Cadmium 100 mM 48 hrs, 4-day adult
60
Copper 0.5 mM 12 hrs, larvae L3
6
Copper 15 mM 48 hrs, 4-day adult
45
Zinc 5 mM 12 hrs, larvae L3
5
Zinc 4.5 mM 48 hrs, 4-day adult
20
Ethanol 2.5% 3 hrs, larvae L3
54
Ethanol 5% 3 hrs, larvae L3
10
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
48
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
40
Paraquat 10 mM 48 hrs, 4-day adult
38
Rotenone 2 μg 12 hrs, larvae L3
10
Rotenone 8 μg 12 hrs, larvae L3
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
14
heat shock, 4-day adult
27
Cadmium 50 mM 6 hrs, larvae L3
8
Cadmium 50 mM 12 hrs, larvae L3
12
Cadmium 50 mM 48 hrs, 4-day adult
26
Cadmium 100 mM 48 hrs, 4-day adult
(60)
Copper 0.5 mM 12 hrs, larvae L3
6
Copper 15 mM 48 hrs, 4-day adult
(45)
Zinc 5 mM 12 hrs, larvae L3
5
Zinc 4.5 mM 48 hrs, 4-day adult
20
Ethanol 2.5% 3 hrs, larvae L3
(54)
Ethanol 5% 3 hrs, larvae L3
10
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(48)
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
(40)
Paraquat 10 mM 48 hrs, 4-day adult
(38)
Rotenone 2 μg 12 hrs, larvae L3
10
Rotenone 8 μg 12 hrs, larvae L3
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
14
heat shock, 4-day adult
27
Cadmium 50 mM 6 hrs, larvae L3
8
Cadmium 50 mM 12 hrs, larvae L3
12
Cadmium 50 mM 48 hrs, 4-day adult
26
Cadmium 100 mM 48 hrs, 4-day adult
60
Copper 0.5 mM 12 hrs, larvae L3
6
Copper 15 mM 48 hrs, 4-day adult
45
Zinc 5 mM 12 hrs, larvae L3
5
Zinc 4.5 mM 48 hrs, 4-day adult
20
Ethanol 2.5% 3 hrs, larvae L3
54
Ethanol 5% 3 hrs, larvae L3
10
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
48
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
40
Paraquat 10 mM 48 hrs, 4-day adult
38
Rotenone 2 μg 12 hrs, larvae L3
10
Rotenone 8 μg 12 hrs, larvae L3
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
14
heat shock, 4-day adult
27
Cadmium 50 mM 6 hrs, larvae L3
8
Cadmium 50 mM 12 hrs, larvae L3
12
Cadmium 50 mM 48 hrs, 4-day adult
26
Cadmium 100 mM 48 hrs, 4-day adult
60
Copper 0.5 mM 12 hrs, larvae L3
6
Copper 15 mM 48 hrs, 4-day adult
45
Zinc 5 mM 12 hrs, larvae L3
5
Zinc 4.5 mM 48 hrs, 4-day adult
20
Ethanol 2.5% 3 hrs, larvae L3
54
Ethanol 5% 3 hrs, larvae L3
10
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
48
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
40
Paraquat 10 mM 48 hrs, 4-day adult
38
Rotenone 2 μg 12 hrs, larvae L3
10
Rotenone 8 μg 12 hrs, larvae L3
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 1 ) For All Classical Alleles Show Allele of
Trn Class Mutagen Stocks Known lesion TrnMI03279 1 --
Alleles Carried on Transgenic Constructs
( 5 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Disrupted in Transgenic Constructs & Insertions
Transgenic Constructs Insertions Gene Ontology: Function, Process
& Cellular Component ( 5 unique terms ) Terms Based on
Experimental Evidence ( 2 terms ) Molecular Function ( 0 terms) Biological Process inferred from mutant phenotype
inferred from mutant phenotype
Cellular Component ( 0 terms) Terms Based on Predictions or
Assertions ( 3 terms ) Molecular Function Biological Process Cellular Component Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
protein-protein anti tag coimmunoprecipitation, peptide massfingerprinting
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (46)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG6N050B )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Orthologs in non-Drosophila Dipterans
(EOG62Z4Z6 )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG69064V )
Apis mellifera
Western honey bee
Amel\LOC408842
Y
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006021
Y
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH15678
Y
Atta cephalotes
Leafcutter ant
Acep\ACEP14906
Y
Camponotus floridanus
Florida carpenter ant
Cflo\CFLO12950
Y
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL23002
Y
Linepithema humile
Argentine ant
Lhum\LH12460
Y
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB12087
Y
Solenopsis invicta
Red fire ant
Sinv\SINV11799
Y
Acyrthosiphon pisum
Pea aphid
Y
Pediculus humanus
Human body louse
Y
Tribolium castaneum
Red flour beetle
Y
Orthologs in non-Insect Arthropods
(EOG663XST )
Daphnia pulex
Water flea
Y
Daphnia pulex
Water flea
Y
Ixodes scapularis
Deer tick
Y
Orthologs in non-Arthropod Metazoa
(EOG6T1WD8 )
Caenorhabditis elegans
Nematode
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Xenopus tropicalis
Western clawed frog
Y
Xenopus tropicalis
Western clawed frog
Y
Gallus gallus
Domestic chicken
Y
Mus musculus
House mouse
Y
Mus musculus
House mouse
Y
Rattus norvegicus
Norway rat
Y
Rattus norvegicus
Norway rat
Y
Human Orthologs (2)AAA Orthologs (1)
based on analysis using Dmel annotation version 4.3
Stocks & Reagents Stocks Listed in FlyBase ( 6 )Bloomington VDRC Genomic Clones ( 1 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 172 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for identity of: Trn CG7398
Source for database merge of Additional comments Other Comments S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
Trn has been cloned and sequenced.
External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 9 )Reported As Symbol Synonym Trn
(
Stroschein-Stevenson et al., 2006 ,
Baeg et al., 2007 ,
Hazelett et al., 2012 ,
Doheny et al., 2008 ,
Bandyopadhyay et al., 2006 ,
Neumüller et al., 2011 ,
Japanese National Institute of Genetics, 2012.5.21 ,
Lindquist et al., 2011 )
Name Synonym Secondary FlyBase
IDs References ( 38 )Generate a list of List References by type
Recent research papers ( 3 )
Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Lindquist et al., 2011, Genome Res. 21(3): 433--446Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. [FBrf0213199] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621]
Recent reviews (0)
All reviews listed in FlyBase were published before 2011