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Gene Dmel\ssx

General Information
Symbol	Dmel\ssx	Species	D. melanogaster
Name	sister-of-Sex-lethal	Annotation symbol	CG3056
Feature type	protein_coding_gene	FlyBase ID	FBgn0024987
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	EG:132E8.1
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	2A1-2A1	Sequence location	X:1,264,613..1,269,290 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene sister-of-Sex-lethal is referred to in FlyBase by the symbol Dmel\ssx (CG3056, FBgn0024987). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. There is experimental evidence that it is involved in the biological process: defense response to bacterium. 10 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; Paraneoplastic encephalomyelitis antigen; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627150_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG3056. Gene sequence location is X:1264613..1269290.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 2A1-2A1   Limits computationally determined from genome sequence between P{EP}EP1542 and P{EP}futschEP1419
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ssx for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ssx-RB FBtr0070215  NM_206603   3055   443 ssx-RC FBtr0339772     3096   167 ssx-RD FBtr0339773     2945   485 ssx-RE FBtr0339774     3635   443
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ssx-PB   FBpp0089110   48.9   443   6.95     NP_996326   AAS65244 ssx-PC   FBpp0308819   18.5   167   4.19       ssx-PD   FBpp0308820   53.4   485   7.01       ssx-PE   FBpp0308821   48.9   443   6.95
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Paraneoplastic encephalomyelitis antigen (IPR002343) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390419   AA390463   AA390540   AA390863   AA391356   AA392139   AA439408   AA439831   AA440864   AA441313   AA698667   AA735458   AA816729   AA817171   AE014298 AAS65244   AF171797   AI107099   AI292805   AI292818   AI292820   AI405622   AI520003   AI520435   AI534471   AI534662   AL023893 CAA19655   AW944509   BG637918   BG637933   BI162974   BI165466   BI166379   BI213544   BI228666   BI239608   BI239731   BI240267   BI353312   BI365184   BI365186   BI366518   BI369995   BI371708   BI371717   BI373291   BI374561   BI375622   BI481915   BI485451   BI486319   BI578699   BI616577   BI637313   BI641315   BI641911   BP558304   BP558305   BT001477 AAN71232   BT003171 AAO24926   BT126218   CK136092   CK604277   CK604278   CL868615   CO188914   CO189060   CO264555   CO273905   CO276288   CO282583   CO298320   CO299460   CO307097   CO310103   CO317094   CO319132   CO319745   CO321723   CO343639   EC062876   EC085023   EC087506   EC088932   EC194851   EC218164   EC221898   EC227462   EC238592   EC239059   EC243406   EC246202   EC260624   EV577284   EV586424   EV588468   EV594458   GH778598   GH941266   GH941433   GH947387   GH952101   GH952192   GH953200   GH957562   GH960000   GH961359   GH961527   GH965498   GH970705   GH978087
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IH14 O76876
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    488.05 Larval Midgut    124.8 Larval Hindgut    188.6 Larval Malpighian Tubules    145.4 Larval Fat Body    139.5 Larval Salivary Gland    231.6 Larval Trachea    288.875 Larval Carcass    200.825 Adult Head    193.6 Adult Eye    308.75 Adult Brain    490.6 Adult Thoracic-Abdominal Ganglion    285.5 Adult Crop    173.7 Adult Midgut    123.3 Adult Hindgut    163.5 Adult Malpighian Tubules    134 Adult Fat Body    97.4 Adult Salivary Gland    322.8 Adult Heart    139.975 Adult VirginFemale Spermatheca    117.7 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    357.5 Adult Testis    69.8 Adult Male Accessory Gland    306.6 Adult Carcass    112.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    488.05 Larval Midgut    124.8 Larval Hindgut    188.6 Larval Malpighian Tubules    145.4 Larval Fat Body    139.5 Larval Salivary Gland    231.6 Larval Trachea    288.875 Larval Carcass    200.825 Adult Head    193.6 Adult Eye    308.75 Adult Brain    490.6 Adult Thoracic-Abdominal Ganglion    285.5 Adult Crop    173.7 Adult Midgut    123.3 Adult Hindgut    163.5 Adult Malpighian Tubules    134 Adult Fat Body    97.4 Adult Salivary Gland    322.8 Adult Heart    139.975 Adult VirginFemale Spermatheca    117.7 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    357.5 Adult Testis    69.8 Adult Male Accessory Gland    306.6 Adult Carcass    112.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    488.05 Larval Midgut    124.8 Larval Hindgut    188.6 Larval Malpighian Tubules    145.4 Larval Fat Body    139.5 Larval Salivary Gland    231.6 Larval Trachea    288.875 Larval Carcass    200.825 Adult Head    193.6 Adult Eye    308.75 Adult Brain    490.6 Adult Thoracic-Abdominal Ganglion    285.5 Adult Crop    173.7 Adult Midgut    123.3 Adult Hindgut    163.5 Adult Malpighian Tubules    134 Adult Fat Body    97.4 Adult Salivary Gland    322.8 Adult Heart    139.975 Adult VirginFemale Spermatheca    117.7 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    357.5 Adult Testis    69.8 Adult Male Accessory Gland    306.6 Adult Carcass    112.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    488.05 Larval Midgut    124.8 Larval Hindgut    188.6 Larval Malpighian Tubules    145.4 Larval Fat Body    139.5 Larval Salivary Gland    231.6 Larval Trachea    288.875 Larval Carcass    200.825 Adult Head    193.6 Adult Eye    308.75 Adult Brain    490.6 Adult Thoracic-Abdominal Ganglion    285.5 Adult Crop    173.7 Adult Midgut    123.3 Adult Hindgut    163.5 Adult Malpighian Tubules    134 Adult Fat Body    97.4 Adult Salivary Gland    322.8 Adult Heart    139.975 Adult VirginFemale Spermatheca    117.7 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    357.5 Adult Testis    69.8 Adult Male Accessory Gland    306.6 Adult Carcass    112.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    488.05 Larval Midgut    124.8 Larval Hindgut    188.6 Larval Malpighian Tubules    145.4 Larval Fat Body    139.5 Larval Salivary Gland    231.6 Larval Trachea    288.875 Larval Carcass    200.825 Adult Head    193.6 Adult Eye    308.75 Adult Brain    490.6 Adult Thoracic-Abdominal Ganglion    285.5 Adult Crop    173.7 Adult Midgut    123.3 Adult Hindgut    163.5 Adult Malpighian Tubules    134 Adult Fat Body    97.4 Adult Salivary Gland    322.8 Adult Heart    139.975 Adult VirginFemale Spermatheca    117.7 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    357.5 Adult Testis    69.8 Adult Male Accessory Gland    306.6 Adult Carcass    112.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    488.05 Larval Midgut    124.8 Larval Hindgut    188.6 Larval Malpighian Tubules    145.4 Larval Fat Body    139.5 Larval Salivary Gland    231.6 Larval Trachea    288.875 Larval Carcass    200.825 Adult Head    193.6 Adult Eye    308.75 Adult Brain    490.6 Adult Thoracic-Abdominal Ganglion    285.5 Adult Crop    173.7 Adult Midgut    123.3 Adult Hindgut    163.5 Adult Malpighian Tubules    134 Adult Fat Body    97.4 Adult Salivary Gland    322.8 Adult Heart    139.975 Adult VirginFemale Spermatheca    117.7 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    357.5 Adult Testis    69.8 Adult Male Accessory Gland    306.6 Adult Carcass    112.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    488.05 Larval Midgut    124.8 Larval Hindgut    188.6 Larval Malpighian Tubules    145.4 Larval Fat Body    139.5 Larval Salivary Gland    231.6 Larval Trachea    288.875 Larval Carcass    200.825 Adult Head    193.6 Adult Eye    308.75 Adult Brain    490.6 Adult Thoracic-Abdominal Ganglion    285.5 Adult Crop    173.7 Adult Midgut    123.3 Adult Hindgut    163.5 Adult Malpighian Tubules    134 Adult Fat Body    97.4 Adult Salivary Gland    322.8 Adult Heart    139.975 Adult VirginFemale Spermatheca    117.7 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    357.5 Adult Testis    69.8 Adult Male Accessory Gland    306.6 Adult Carcass    112.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    488.05 Larval Midgut    124.8 Larval Hindgut    188.6 Larval Malpighian Tubules    145.4 Larval Fat Body    139.5 Larval Salivary Gland    231.6 Larval Trachea    288.875 Larval Carcass    200.825 Adult Head    193.6 Adult Eye    308.75 Adult Brain    490.6 Adult Thoracic-Abdominal Ganglion    285.5 Adult Crop    173.7 Adult Midgut    123.3 Adult Hindgut    163.5 Adult Malpighian Tubules    134 Adult Fat Body    97.4 Adult Salivary Gland    322.8 Adult Heart    139.975 Adult VirginFemale Spermatheca    117.7 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    357.5 Adult Testis    69.8 Adult Male Accessory Gland    306.6 Adult Carcass    112.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    193.6   NA  Eye    308.75   NA  Brain    490.6   488.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    285.5   NA  Crop    173.7   124.8  Midgut    123.3   188.6  Hindgut    163.5   145.4  Malpighian Tubules    134   139.5  Fat Body    97.4   231.6  Salivary Gland    322.8   NA  Heart    139.975   288.875  Trachea    NA   NA  VirginFemale Spermatheca    117.7   NA  InseminatedFemale Spermatheca    117.1   NA  Ovary    357.5   NA  Testis    69.8   NA  Male Accessory Gland    306.6   200.825  Carcass    112.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    69 central nervous system, larvae L3    122 central nervous system, pupae P8    103 head, virgin 1-day female    59 head, virgin 4-day female    75 head, virgin 20-day female    31 head, mated 1-day female    66 head, mated 4-day female    51 head, mated 20-day female    36 head, mated 1-day male    116 head, mated 4-day male    114 head, mated 20-day male    83 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    20 fat body, larvae L3 wandering    18 fat body, white prepupae    31 fat body, pupae P8    59 carcass, larvae L3 wandering    51 carcass, 1-day adult    24 carcass, 4-day adult    33 carcass, 20-day adult    29 ovary, virgin 4-day female    74 ovary, mated 4-day female    85 testis, mated 4-day male    10 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (69) central nervous system, larvae L3  (122) central nervous system, pupae P8  (103) head, virgin 1-day female  (59) head, virgin 4-day female  (75) head, virgin 20-day female  (31) head, mated 1-day female  (66) head, mated 4-day female  (51) head, mated 20-day female  (36) head, mated 1-day male  (116) head, mated 4-day male  (114) head, mated 20-day male  (83) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (35) digestive system, larvae L3 wandering  26 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    20 fat body, larvae L3 wandering    18 fat body, white prepupae  (31) fat body, pupae P8  (59) carcass, larvae L3 wandering  (51) carcass, 1-day adult    24 carcass, 4-day adult  (33) carcass, 20-day adult  (29) ovary, virgin 4-day female  (74) ovary, mated 4-day female  (85) testis, mated 4-day male    10 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    69 central nervous system, larvae L3  (122) central nervous system, pupae P8  103 head, virgin 1-day female    59 head, virgin 4-day female    75 head, virgin 20-day female    31 head, mated 1-day female    66 head, mated 4-day female    51 head, mated 20-day female    36 head, mated 1-day male  (116) head, mated 4-day male  (114) head, mated 20-day male    83 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    20 fat body, larvae L3 wandering    18 fat body, white prepupae    31 fat body, pupae P8    59 carcass, larvae L3 wandering    51 carcass, 1-day adult    24 carcass, 4-day adult    33 carcass, 20-day adult    29 ovary, virgin 4-day female    74 ovary, mated 4-day female    85 testis, mated 4-day male    10 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    69 central nervous system, larvae L3    122 central nervous system, pupae P8    103 head, virgin 1-day female    59 head, virgin 4-day female    75 head, virgin 20-day female    31 head, mated 1-day female    66 head, mated 4-day female    51 head, mated 20-day female    36 head, mated 1-day male    116 head, mated 4-day male    114 head, mated 20-day male    83 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    20 fat body, larvae L3 wandering    18 fat body, white prepupae    31 fat body, pupae P8    59 carcass, larvae L3 wandering    51 carcass, 1-day adult    24 carcass, 4-day adult    33 carcass, 20-day adult    29 ovary, virgin 4-day female    74 ovary, mated 4-day female    85 testis, mated 4-day male    10 accessory gland, mated 4-day male    22 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    69 central nervous system, larvae L3    122 central nervous system, pupae P8    103 head, virgin 1-day female    59 head, virgin 4-day female    75 head, virgin 20-day female    31 head, mated 1-day female    66 head, mated 4-day female    51 head, mated 20-day female    36 head, mated 1-day male    116 head, mated 4-day male    114 head, mated 20-day male    83 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    20 fat body, larvae L3 wandering    18 fat body, white prepupae    31 fat body, pupae P8    59 carcass, larvae L3 wandering    51 carcass, 1-day adult    24 carcass, 4-day adult    33 carcass, 20-day adult    29 ovary, virgin 4-day female    74 ovary, mated 4-day female    85 testis, mated 4-day male    10 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (69) central nervous system, larvae L3  (122) central nervous system, pupae P8  (103) head, virgin 1-day female  (59) head, virgin 4-day female  (75) head, virgin 20-day female  31 head, mated 1-day female  (66) head, mated 4-day female  (51) head, mated 20-day female  (36) head, mated 1-day male  (116) head, mated 4-day male  (114) head, mated 20-day male  (83) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (35) digestive system, larvae L3 wandering  26 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    20 fat body, larvae L3 wandering    18 fat body, white prepupae  31 fat body, pupae P8  (59) carcass, larvae L3 wandering  (51) carcass, 1-day adult    24 carcass, 4-day adult  (33) carcass, 20-day adult  29 ovary, virgin 4-day female  (74) ovary, mated 4-day female  (85) testis, mated 4-day male    10 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    69 central nervous system, larvae L3  122 central nervous system, pupae P8  103 head, virgin 1-day female    59 head, virgin 4-day female    75 head, virgin 20-day female    31 head, mated 1-day female    66 head, mated 4-day female    51 head, mated 20-day female    36 head, mated 1-day male  116 head, mated 4-day male  114 head, mated 20-day male    83 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    20 fat body, larvae L3 wandering    18 fat body, white prepupae    31 fat body, pupae P8    59 carcass, larvae L3 wandering    51 carcass, 1-day adult    24 carcass, 4-day adult    33 carcass, 20-day adult    29 ovary, virgin 4-day female    74 ovary, mated 4-day female    85 testis, mated 4-day male    10 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    69 central nervous system, larvae L3    122 central nervous system, pupae P8    103 head, virgin 1-day female    59 head, virgin 4-day female    75 head, virgin 20-day female    31 head, mated 1-day female    66 head, mated 4-day female    51 head, mated 20-day female    36 head, mated 1-day male    116 head, mated 4-day male    114 head, mated 20-day male    83 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    20 fat body, larvae L3 wandering    18 fat body, white prepupae    31 fat body, pupae P8    59 carcass, larvae L3 wandering    51 carcass, 1-day adult    24 carcass, 4-day adult    33 carcass, 20-day adult    29 ovary, virgin 4-day female    74 ovary, mated 4-day female    85 testis, mated 4-day male    10 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    68 embryo 02-04hr    106 embryo 04-06hr    90 embryo 06-08hr    79 embryo 08-10hr    74 embryo 10-12hr    49 embryo 12-14hr    53 embryo 14-16hr    60 embryo 16-18hr    44 embryo 18-20hr    28 embryo 20-22hr    46 embryo 22-24hr    37 larva L1    25 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    30 white prepupae new    33 white prepupae 12hr    34 white prepupae 24hr    44 pupae 2d postWPP    36 pupae 3d postWPP    23 pupae 4d postWPP    23 adult male 01day    23 adult male 05day    26 adult male 30day    30 adult female 01day    33 adult female 05day    34 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (68) embryo 02-04hr  (106) embryo 04-06hr  (90) embryo 06-08hr  (79) embryo 08-10hr  (74) embryo 10-12hr  (49) embryo 12-14hr  (53) embryo 14-16hr  (60) embryo 16-18hr  (44) embryo 18-20hr  (28) embryo 20-22hr  (46) embryo 22-24hr  (37) larva L1    25 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  (30) white prepupae new  (33) white prepupae 12hr  (34) white prepupae 24hr  (44) pupae 2d postWPP  (36) pupae 3d postWPP    23 pupae 4d postWPP    23 adult male 01day    23 adult male 05day  26 adult male 30day  (30) adult female 01day  (33) adult female 05day  (34) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    68 embryo 02-04hr  106 embryo 04-06hr    90 embryo 06-08hr    79 embryo 08-10hr    74 embryo 10-12hr    49 embryo 12-14hr    53 embryo 14-16hr    60 embryo 16-18hr    44 embryo 18-20hr    28 embryo 20-22hr    46 embryo 22-24hr    37 larva L1    25 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    30 white prepupae new    33 white prepupae 12hr    34 white prepupae 24hr    44 pupae 2d postWPP    36 pupae 3d postWPP    23 pupae 4d postWPP    23 adult male 01day    23 adult male 05day    26 adult male 30day    30 adult female 01day    33 adult female 05day    34 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    68 embryo 02-04hr    106 embryo 04-06hr    90 embryo 06-08hr    79 embryo 08-10hr    74 embryo 10-12hr    49 embryo 12-14hr    53 embryo 14-16hr    60 embryo 16-18hr    44 embryo 18-20hr    28 embryo 20-22hr    46 embryo 22-24hr    37 larva L1    25 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    30 white prepupae new    33 white prepupae 12hr    34 white prepupae 24hr    44 pupae 2d postWPP    36 pupae 3d postWPP    23 pupae 4d postWPP    23 adult male 01day    23 adult male 05day    26 adult male 30day    30 adult female 01day    33 adult female 05day    34 adult female 30day    34 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    68 embryo 02-04hr    106 embryo 04-06hr    90 embryo 06-08hr    79 embryo 08-10hr    74 embryo 10-12hr    49 embryo 12-14hr    53 embryo 14-16hr    60 embryo 16-18hr    44 embryo 18-20hr    28 embryo 20-22hr    46 embryo 22-24hr    37 larva L1    25 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    30 white prepupae new    33 white prepupae 12hr    34 white prepupae 24hr    44 pupae 2d postWPP    36 pupae 3d postWPP    23 pupae 4d postWPP    23 adult male 01day    23 adult male 05day    26 adult male 30day    30 adult female 01day    33 adult female 05day    34 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (68) embryo 02-04hr  (106) embryo 04-06hr  (90) embryo 06-08hr  (79) embryo 08-10hr  (74) embryo 10-12hr  (49) embryo 12-14hr  (53) embryo 14-16hr  (60) embryo 16-18hr  (44) embryo 18-20hr  28 embryo 20-22hr  (46) embryo 22-24hr  (37) larva L1    25 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  30 white prepupae new  (33) white prepupae 12hr  (34) white prepupae 24hr  (44) pupae 2d postWPP  (36) pupae 3d postWPP    23 pupae 4d postWPP    23 adult male 01day    23 adult male 05day  26 adult male 30day  30 adult female 01day  (33) adult female 05day  (34) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    68 embryo 02-04hr  106 embryo 04-06hr    90 embryo 06-08hr    79 embryo 08-10hr    74 embryo 10-12hr    49 embryo 12-14hr    53 embryo 14-16hr    60 embryo 16-18hr    44 embryo 18-20hr    28 embryo 20-22hr    46 embryo 22-24hr    37 larva L1    25 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    30 white prepupae new    33 white prepupae 12hr    34 white prepupae 24hr    44 pupae 2d postWPP    36 pupae 3d postWPP    23 pupae 4d postWPP    23 adult male 01day    23 adult male 05day    26 adult male 30day    30 adult female 01day    33 adult female 05day    34 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    68 embryo 02-04hr    106 embryo 04-06hr    90 embryo 06-08hr    79 embryo 08-10hr    74 embryo 10-12hr    49 embryo 12-14hr    53 embryo 14-16hr    60 embryo 16-18hr    44 embryo 18-20hr    28 embryo 20-22hr    46 embryo 22-24hr    37 larva L1    25 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    30 white prepupae new    33 white prepupae 12hr    34 white prepupae 24hr    44 pupae 2d postWPP    36 pupae 3d postWPP    23 pupae 4d postWPP    23 adult male 01day    23 adult male 05day    26 adult male 30day    30 adult female 01day    33 adult female 05day    34 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    109 Schneider line 2 Sg4    50 embryonic 1182-4H    54 embryonic GM2    55 embryonic Kc167    35 embryonic S1    70 embryonic S3    73 leg disc CME L1    94 wing disc CME-W2    72 wing disc ML-DmD8    89 wing disc ML-DmD9    74 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    22 wing disc ML-DmD32    68 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    48 ovary fGS/OSS    95 ovary OSC    203 ovary OSS    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (109) Schneider line 2 Sg4  (50) embryonic 1182-4H  (54) embryonic GM2  (55) embryonic Kc167  (35) embryonic S1  (70) embryonic S3  (73) leg disc CME L1  (94) wing disc CME-W2  (72) wing disc ML-DmD8  (89) wing disc ML-DmD9  (74) wing disc ML-DmD16-c3  (47) wing disc ML-DmD21    22 wing disc ML-DmD32  (68) haltere disc ML-DmD17-c3  (70) eye-antennal disc ML-DmD11  (64) antennal disc ML-DmD20-c5  (44) mixed discs ML-DmD4-c1  (62) CNS ML-DmBG1-c1  (41) CNS ML-DmBG2-c2  (58) tumorous blood cells mbn2  (48) ovary fGS/OSS  (95) ovary OSC  (203) ovary OSS  (78) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (109) Schneider line 2 Sg4    50 embryonic 1182-4H    54 embryonic GM2    55 embryonic Kc167    35 embryonic S1    70 embryonic S3    73 leg disc CME L1    94 wing disc CME-W2    72 wing disc ML-DmD8    89 wing disc ML-DmD9    74 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    22 wing disc ML-DmD32    68 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    48 ovary fGS/OSS    95 ovary OSC  (203) ovary OSS    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    109 Schneider line 2 Sg4    50 embryonic 1182-4H    54 embryonic GM2    55 embryonic Kc167    35 embryonic S1    70 embryonic S3    73 leg disc CME L1    94 wing disc CME-W2    72 wing disc ML-DmD8    89 wing disc ML-DmD9    74 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    22 wing disc ML-DmD32    68 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    48 ovary fGS/OSS    95 ovary OSC    203 ovary OSS    78 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    109 Schneider line 2 Sg4    50 embryonic 1182-4H    54 embryonic GM2    55 embryonic Kc167    35 embryonic S1    70 embryonic S3    73 leg disc CME L1    94 wing disc CME-W2    72 wing disc ML-DmD8    89 wing disc ML-DmD9    74 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    22 wing disc ML-DmD32    68 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    48 ovary fGS/OSS    95 ovary OSC    203 ovary OSS    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (109) Schneider line 2 Sg4  (50) embryonic 1182-4H  (54) embryonic GM2  (55) embryonic Kc167  (35) embryonic S1  (70) embryonic S3  (73) leg disc CME L1  (94) wing disc CME-W2  (72) wing disc ML-DmD8  (89) wing disc ML-DmD9  (74) wing disc ML-DmD16-c3  (47) wing disc ML-DmD21    22 wing disc ML-DmD32  (68) haltere disc ML-DmD17-c3  (70) eye-antennal disc ML-DmD11  (64) antennal disc ML-DmD20-c5  (44) mixed discs ML-DmD4-c1  (62) CNS ML-DmBG1-c1  (41) CNS ML-DmBG2-c2  (58) tumorous blood cells mbn2  (48) ovary fGS/OSS  (95) ovary OSC  (203) ovary OSS  (78) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  109 Schneider line 2 Sg4    50 embryonic 1182-4H    54 embryonic GM2    55 embryonic Kc167    35 embryonic S1    70 embryonic S3    73 leg disc CME L1    94 wing disc CME-W2    72 wing disc ML-DmD8    89 wing disc ML-DmD9    74 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    22 wing disc ML-DmD32    68 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    48 ovary fGS/OSS    95 ovary OSC  (203) ovary OSS    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    109 Schneider line 2 Sg4    50 embryonic 1182-4H    54 embryonic GM2    55 embryonic Kc167    35 embryonic S1    70 embryonic S3    73 leg disc CME L1    94 wing disc CME-W2    72 wing disc ML-DmD8    89 wing disc ML-DmD9    74 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    22 wing disc ML-DmD32    68 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    48 ovary fGS/OSS    95 ovary OSC    203 ovary OSS    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    47 cold shock, 4-day adult    43 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    73 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    61 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    56 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    77 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (47) cold shock, 4-day adult  (43) heat shock, 4-day adult  (32) Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult  (40) Cadmium 100 mM 48 hrs, 4-day adult  (73) Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult  (61) Zinc 5 mM 12 hrs, larvae L3  26 Zinc 4.5 mM 48 hrs, 4-day adult  (56) Ethanol 2.5% 3 hrs, larvae L3  (47) Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (77) Caffeine 25 mg/ml 48 hrs, 4-day adult  (57) Paraquat 5 mM 48 hrs, 4-day adult  (61) Paraquat 10 mM 48 hrs, 4-day adult  (36) Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    47 cold shock, 4-day adult    43 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    73 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    61 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    56 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    77 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    47 cold shock, 4-day adult    43 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    73 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    61 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    56 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    77 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    47 cold shock, 4-day adult    43 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    73 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    61 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    56 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    77 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (47) cold shock, 4-day adult  (43) heat shock, 4-day adult  32 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult  (40) Cadmium 100 mM 48 hrs, 4-day adult  (73) Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult  (61) Zinc 5 mM 12 hrs, larvae L3  26 Zinc 4.5 mM 48 hrs, 4-day adult  (56) Ethanol 2.5% 3 hrs, larvae L3  (47) Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (77) Caffeine 25 mg/ml 48 hrs, 4-day adult  (57) Paraquat 5 mM 48 hrs, 4-day adult  (61) Paraquat 10 mM 48 hrs, 4-day adult  (36) Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    47 cold shock, 4-day adult    43 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    73 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    61 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    56 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    77 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    47 cold shock, 4-day adult    43 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    73 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    61 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    56 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    77 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024987 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3056-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable ssx55 ssx+Rev26 ssxd05625 ssxEY14203 Sterility Allele female fertile ssx55 fertile ssxd05625 ssxEY14203 male fertile ssx55 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of ssx Class Mutagen Stocks Known lesion ssxd05625 P-element activity 2 Yes ssxEY14203 P-element activity 1 -- ssx+Rev26 Delta2-3 0 Yes ssx55 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ssx Class Mutagen Stocks Known lesion ssxHMS02574 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ssxKK109594 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ssxdsRNA.cDa in vitro construct - RNAi 0 Yes ssxdsRNA.cDb in vitro construct - RNAi 0 Yes ssxGD10114 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ssxNIG.3056R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(1)ssx55 (Cline et al., 2010)
Disrupted in	Df(1)Exel6227 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.3056R} NA P{TRiP.HMS02574} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}ssxEY14203 NA P{XP}ssxd05625 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
defense response to bacterium inferred from mutant phenotype (Ayres et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-) RNA binding inferred from electronic annotation with InterPro:IPR002343 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
ssx - CG4847 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ssx - CG8336 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ssx - Liprin-α anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ssx - Mp20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ssx - PCID2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ssx - p-cup anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ssx - p53 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ssx - stv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ssx allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57646 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0024987 DroID - A comprehensive database of gene and protein interactions. • FBgn0024987 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31086
Orthologs
OrthoDB Orthologs (28) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PCBCD Dipteran inclusive ortholog search EOG6N8RDJ Insect inclusive ortholog search EOG66130S Arthropod inclusive ortholog search EOG66HDSD Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6PCBCD)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\ssx     Drosophila simulans   Dsim\GD16553 Y   Drosophila sechellia   Dsec\GM19131 Y   Drosophila erecta   Dere\GG12847 Y   Drosophila yakuba   Dyak\GE16683 Y   Drosophila ananassae   Dana\GF21012 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22715 Y   Drosophila persimilis   Dper\GL14245 Y   Drosophila willistoni   Dwil\GK16696 Y   Drosophila virilis   Dvir\ssx Y
Orthologs in non-Drosophila Dipterans (EOG6N8RDJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011150 Y Anopheles gambiae Malaria mosquito  Agam\sxl Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013809 Y
Orthologs in non-Dipteran Insects (EOG66130S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43841 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000104 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12796 Y Atta cephalotes Leafcutter ant  Acep\ACEP22069 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14846 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19441 Y Linepithema humile Argentine ant  Lhum\LH12197 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB16327 Y Solenopsis invicta Red fire ant  Sinv\SINV12046 Y Acyrthosiphon pisum Pea aphid  Apim\sxl Y Pediculus humanus Human body louse  Phum\PHUM608000 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15366-OG17950 Y
Orthologs in non-Insect Arthropods (EOG66HDSD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rpmH Y Daphnia pulex Water flea  Dpux\JGI_V11_299722 Y Ixodes scapularis Deer tick  Isca\ISCW021980 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16553 Drosophila sechellia Dsec\GM19131 Drosophila erecta Dere\GG12847 Drosophila yakuba Dyak\GE16683 Drosophila ananassae Dana\GF21012 Drosophila pseudoobscura pseudoobscura Dpse\GA22715 Drosophila persimilis Dper\GL14245 Drosophila willistoni Dwil\GK16696 Drosophila virilis Dvir\ssx Drosophila mojavensis Dmoj\GI16327 Drosophila grimshawi Dgri\GH12116
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	19220 P{XP}ssxd05625 w1118 20792 y1 P{EPgy2}ssxEY14203 w67c23 42881 y1 sc* v1; P{TRiP.HMS02574}attP2/TM3, Sb1
Harvard	- P{XP}ssxd05625
VDRC	v101781 P{KK109594}VIE-260B
Genomic Clones ( 2 )
	BACR09H15 BACR30G24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 98 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21345 LD25793 SD07604
Other clones	AF171797
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06393 GH15806 GH15819 GH15821 GH25708 GM23106 HL05440 LD05108 LD09074 LD09357 LD10246 LD11003 LD13971 LD14507 LD15915 LD16203 LD22340 LD39920 LD40601 RE02260 RE05373 RE06489 RE18966 RE26285 RE36151 RE36306 RE36968 RE50423 RE50425 RE52072 RE56354 RE58652 RE58664 RE60549 RE62185 RE63476 RE64538 RE68774 RE69737 RE72601 RH46588 SD07307 SD19286 SD24545
Other clones	35075 44963 59281 59814 98128 148239 162951 175729 214571.17 CK01.23B.G12 CK01.52B.G6 CK01.146B.G6 Dmel_dig_011077_0704_2506 Dmel_neb_012944_0145_3147 Dmel_neb_013622_0121_2956 Dmel_neb_014376_0589_2249 EK042359 EK042909 EK112607 EK120259 EK139605 EK160754 EK172744 EK175505 EK186245 EK220512 EK253555 EK267114 EK276346 EK280321 EP17641 FGM314B12 LD08780 LD09340 RP003244872 RP004055670 RP004133381 RP004148424 RP004149045 RP004209986 RP004264153 RP004267175 RP004268406 RP004423259 RP004491737 RP004535001 RP004535810 RP004549963 SD25575 UT01056
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024987 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31086
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ssx CG3056 (Cline et al., 2010)
Source for database merge of	Source for merge of: CG3056 anon-EST:Posey102 (Ashburner, 2004.6.30)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_206603 RefSeq (Proteins) • NP_996326 DDBJ / EMBL / GenBank • AA390419 AA735458 AAF45613 AAN71232 AAO24926 AAS65244 AF171797 AI534662 AL023893 AW944509 BG637933 BT001477 BT003171 CAA19655 CL868615 Entrez Gene - A searchable database of RefSeq genes. • 31086 UniProtKB/TrEMBL • O76876 Q8IH14
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Paraneoplastic encephalomyelitis antigen (IPR002343) Nucleotide-binding, alpha-beta plait (IPR012677)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57646 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0024987 DroID - A comprehensive database of gene and protein interactions. • FBgn0024987 DRSC - Results from RNAi screens. • FBgn0024987 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024987 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3056-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024987 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31086 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31086 modMine - Data generated by the modENCODE project. • FBgn0024987
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	anon-EST:Posey102   cg3056 (Lasko, 2000) CG3056 (Cline et al., 2010, Ayres et al., 2008, Sun and Cline, 2007, Ibrahim et al., 2011, Stofanko et al., 2008, Lebo et al., 2009, Keleman et al., 2009.8.5, Traut et al., 2006, Ni et al., 2010.12.1, Japanese National Institute of Genetics, 2012.5.21) EG:132E8.1 (Benos et al., 2001, Giot et al., 2003, Dorner et al., 2006) ssx (Cline et al., 2010)
Name Synonym	sister-of-Sex-lethal (Cline et al., 2010, )
Secondary FlyBase IDs
	FBgn0027771
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Mullon et al., 2012, BMC Evol. Biol. 12: 5 Molecular evolution of Drosophila Sex-lethal and related sex determining genes. [FBrf0217612] Ibrahim et al., 2011, IEEE/ACM Trans. Comput. Biol. Bioinform. 8(2): 326--334 Using qualitative probability in reverse-engineering gene regulatory networks. [FBrf0212951] Show all research papers ...