FlyBase Gene Report: Dmel\ssx

General Information

Symbol

Dmel\ssx

Species

D. melanogaster

Name

sister-of-Sex-lethal

Annotation Symbol

CG3056

Feature Type

protein_coding_gene

FlyBase ID

FBgn0024987

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

EG:132E8.1

Key Links

Genomic Location

Cytogenetic map

2A1-2A1

Sequence location

X:1,370,580..1,375,257 [+]

Recombination map

1-0.2

RefSeq locus

NC_004354 REGION:1370580..1375257

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables RNA binding

inferred from direct assay

(Moschall et al., 2019)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables mRNA 3'-UTR binding

inferred from biological aspect of ancestor with PANTHER:PTN000610044

(assigned by GO_Central )

(Gaudet et al., 2011)

enables mRNA binding

inferred from sequence or structural similarity

(Lasko, 2000)

enables poly(A) binding

inferred from biological aspect of ancestor with PANTHER:PTN000610044

(assigned by GO_Central )

(Gaudet et al., 2011)

enables poly(U) RNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000610044

(assigned by GO_Central )

(Gaudet et al., 2011)

enables RNA binding

inferred from biological aspect of ancestor with PANTHER:PTN002768817

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in defense response to bacterium

inferred from mutant phenotype

(Ayres et al., 2008)

involved_in posttranscriptional gene silencing

inferred from mutant phenotype

(Moschall et al., 2019)

involved_in regulation of RNA splicing

inferred from direct assay

(Moschall et al., 2019)

inferred from mutant phenotype

(Moschall et al., 2019)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

located_in cytoplasmic stress granule

inferred from biological aspect of ancestor with PANTHER:PTN000610046

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000610044

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000610044

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of ribonucleoprotein complex

inferred from biological aspect of ancestor with PANTHER:PTN002768817

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\ssx for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

ssx-RB

FBtr0070215

NM_206603

3055

443

ssx-RC

FBtr0339772

NM_001297845

3096

167

ssx-RD

FBtr0339773

NM_130552

2945

485

ssx-RE

FBtr0339774

NM_001297846

3635

443

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

ssx-PB

FBpp0089110

48.9

443

6.95

NP_996326

AAS65244

ssx-PC

FBpp0308819

18.5

167

4.19

NP_001284774

AHN59245

ssx-PD

FBpp0308820

53.4

485

7.01

NP_569908

AAF45613

ssx-PE

FBpp0308821

48.9

443

6.95

NP_001284775

AHN59246

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

443 aa isoforms: ssx-PB, ssx-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ssx using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

organism

(Moschall et al., 2019)

adult stage | female

organism

(Moschall et al., 2019)

embryonic stage

organism

(Moschall et al., 2019)

Additional Descriptive Data

ssx is expressed in both male and female flies.

(Moschall et al., 2019)

No sex-specific expression of ssx is observed. Unlike Sxl isoforms encoding full open reading frames are produced in both sexes.

(Moschall et al., 2019)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism

(Moschall et al., 2019)

adult stage | female

organism

(Moschall et al., 2019)

adult stage | male

organism

(Moschall et al., 2019)

Additional Descriptive Data

ssx protein is observed in both males and females and in embryos.

(Moschall et al., 2019)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ssx in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ssx

View exonic expression by tissue for Dmel\ssx

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0024987

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3056-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3056

Flygut - An atlas of the Drosophila adult midgut

FBgn0024987

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ssx

Transgenic constructs containing regulatory region of ssx

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation

Gene partially disrupted in

Df(1)ssx55

(Cline et al., 2010)

Gene disrupted in

Df(1)Exel6227

(Ryder, 2004.4.26)

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | heat sensitive, with Scer\GAL4^da.G32

ssx^{UAS.Tag:FLAG,Tag:HA}

partially lethal - majority die, with Scer\GAL4^da.G32

ssx^{UAS.Tag:FLAG,Tag:HA}

viable

viable, with Scer\GAL4^VP16.nos.UTR

ssx^{UASp.Tag:FLAG,Tag:HA}

viable, with Scer\GAL4^VP16.osk

ssx^{UASp.Tag:FLAG,Tag:HA}

viable | male

Sterility

Allele

female fertile

ssx⁵⁵

fertile

fertile, with Scer\GAL4^VP16.nos.UTR

ssx^{UASp.Tag:FLAG,Tag:HA}

fertile, with Scer\GAL4^VP16.osk

ssx^{UASp.Tag:FLAG,Tag:HA}

male fertile

ssx⁵⁵

Other Phenotypes

Allele

some die during embryonic stage, with Scer\GAL4^da.G32

ssx^{UAS.Tag:FLAG,Tag:HA}

some die during larval stage, with Scer\GAL4^da.G32

ssx^{UAS.Tag:FLAG,Tag:HA}

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (45)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\HNRNPA0

2 of 15

Yes

Hsap\HNRNPA1

2 of 15

Yes

Hsap\HNRNPA1L2

2 of 15

Yes

Hsap\HNRNPA2B1

2 of 15

Yes

Hsap\HNRNPA3

2 of 15

Yes

Hsap\HNRNPAB

2 of 15

Yes

Hsap\RBM34

2 of 15

Yes

Hsap\BOLL

1 of 15

Hsap\CIRBP

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\MIR7705

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\RBM4

1 of 15

Hsap\RBM24

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (46)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Hnrnpa0

2 of 15

Yes

Mmus\Hnrnpa1

2 of 15

Yes

Mmus\Hnrnpa2b1

2 of 15

Yes

Mmus\Hnrnpab

2 of 15

Yes

Mmus\Rbm34

2 of 15

Yes

Mmus\Boll

1 of 15

Mmus\Cirbp

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Rbm4

1 of 15

Mmus\Rbm24

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Rattus norvegicus (Norway rat) (43)

Rnor\Hnrnpa1

2 of 13

Yes

Rnor\Hnrnpa2b1

2 of 13

Yes

Rnor\LOC681410

2 of 13

Yes

Rnor\LOC103689931

2 of 13

Yes

Rnor\Rbm34

2 of 13

Yes

Rnor\Boll

1 of 13

Rnor\Cirbp

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (33)

Xtro\hnrnpa0

2 of 12

Yes

Xtro\hnrnpa1

2 of 12

Yes

Xtro\hnrnpa2b1

2 of 12

Yes

Xtro\hnrnpa3

2 of 12

Yes

Xtro\hnrnpab

2 of 12

Yes

Xtro\rbm34

2 of 12

Yes

Xtro\cirbp

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (49)

Drer\hnrnpa0a

2 of 15

Yes

Drer\hnrnpa0l

2 of 15

Yes

Drer\hnrnpa1b

2 of 15

Yes

Drer\hnrnpa3

2 of 15

Yes

Drer\hnrnpaba

2 of 15

Yes

Drer\hnrnpabb

2 of 15

Yes

Drer\rbm34

2 of 15

Yes

Drer\cirbpa

1 of 15

Yes

Drer\cirbpb

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\zgc:55733

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\daz-1

1 of 15

Yes

Cele\exc-7

1 of 15

Yes

Cele\H28G03.1

1 of 15

Yes

Cele\hrp-1

1 of 15

Yes

Cele\rbm-34

1 of 15

Yes

Cele\rnp-1

1 of 15

Yes

Cele\slrp-1

1 of 15

Yes

Cele\T07F10.3

1 of 15

Yes

Cele\tdp-1

1 of 15

Yes

Cele\ZK616.61

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (23)

Atha\AT2G35410

2 of 9

Yes

Atha\CP31B

2 of 9

Yes

Atha\CP33

2 of 9

Yes

Atha\RBP31

2 of 9

Yes

Atha\AT1G01080

1 of 9

Yes

Atha\AT1G03457

1 of 9

Atha\AT1G60000

1 of 9

Atha\AT2G22088

1 of 9

Yes

Atha\AT2G22100

1 of 9

Atha\AT2G37220

1 of 9

Yes

Atha\AT2G41060

1 of 9

Yes

Atha\AT2G47310

1 of 9

Atha\AT3G15010

1 of 9

Atha\AT4G09040

1 of 9

Yes

Atha\AT5G03495

1 of 9

Yes

Atha\AT5G51730

1 of 9

Yes

Atha\AT5G53700

1 of 9

Yes

Atha\CP29

1 of 9

Yes

Atha\NUC-L1

1 of 9

Yes

Atha\NUC-L2

1 of 9

Yes

Atha\PHIP1

1 of 9

Yes

Atha\RBP-DR1

1 of 9

Atha\UBA2A

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (16)

Scer\GBP2

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Scer\MUD1

1 of 15

Scer\NAB3

1 of 15

Scer\NAB6

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Scer\TIF3

1 of 15

Scer\WHI3

1 of 15

Scer\WHI4

1 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\crp79

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190DPF )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA22715

Drosophila persimilis

Dper\GL14245

Drosophila willistoni

Dwil\GK16696

Drosophila virilis

Dvir\ssx

Drosophila mojavensis

Dmoj\GI16327

Drosophila grimshawi

Dgri\GH12116

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915097F )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17022160

Glossina morsitans

Tsetse fly

Gmor\GMOY012172

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_03391

Mayetiola destructor

Hessian fly

Mdes\Mdes007964

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL011150

Anopheles darlingi

American malaria mosquito

Adar\ADAC009061

Anopheles gambiae

Malaria mosquito

Agam\sxl

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013809

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0EOR )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Danaus plexippus

Monarch butterfly

Dple\DPOGS206861-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL006151

Apis florea

Little honeybee

Aflo\2202285220

Apis mellifera

Western honey bee

Amel\GB43841

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP14375

Bombus terrestris

Buff-tailed bumblebee

Bter\15204253

Linepithema humile

Argentine ant

Lhum\LH12197

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001bdf

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG000104

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_10895

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_15366-OG17950

Pediculus humanus

Human body louse

Phum\PHUM608000

Acyrthosiphon pisum

Pea aphid

Apim\sxl

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01286

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07KE )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR011089

Ixodes scapularis

Black-legged tick

Isca\ISCW010302

Ixodes scapularis

Black-legged tick

Isca\ISCW021980

Stegodyphus mimosarum

African social velvet spider

Smim\KFM56687.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM62965.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM70494.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur05g00810

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_290551

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_98025

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0G9L )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-ElavL

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000004712

Gallus gallus

Domestic chicken

Ggal\ELAVL2

Gallus gallus

Domestic chicken

Ggal\ELAVL4

Gallus gallus

Domestic chicken

Ggal\ELAVL1

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (40)

Gene Symbol

Score

Source

Alignment

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

Spx

2 of 10

Sxl

2 of 10

bol

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

fne

1 of 10

hfp

1 of 10

lark

1 of 10

Larp7

1 of 10

mod

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

trv

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

ssx - Myc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

ssx - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

ssx - d

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

ssx - gig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

ssx - orb2

anti tag coimmunoprecipitation, western blot

(Khan et al., 2015)

ssx - p53

pull down, autoradiography

(Lunardi et al., 2010)

RNA-protein

Physical Interaction

Assay

References

ssx - Sxl

clip-seq

(Moschall et al., 2019)

ssx - msl-2

electrophoretic mobility shift assay, autoradiography, anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Moschall et al., 2018)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Sxl

suppressible

ssx

(Cline et al., 2010)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

57646

DroID - A comprehensive database of gene and protein interactions.

FBgn0024987

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

31086

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-0.2

Cytogenetic map

2A1-2A1

Sequence location

X:1,370,580..1,375,257 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

2A1-2A1

Limits computationally determined from genome sequence between P{EP}EP1542 and P{EP}futsch^EP1419

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-0.2

(FlyBase, 2016)

1-0.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Bloomington

20792

y¹ P{EPgy2}ssx^EY14203 w^67c23

42881

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02574}attP2/TM3, Sb¹

VDRC

v101781

P{KK109594}VIE-260B

v341829

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00981}attP40/CyO-GFP

v341956

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01253}attP40/CyO-GFP

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (94)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

AF171797

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0024987

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0024987

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31086

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Moschall et al., 2019)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: ssx CG3056

(Cline et al., 2010)

Source for database merge of

Source for merge of: CG3056 anon- EST:Posey102

(Ashburner, 2004.6.30)

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31086

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0024987

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3056

Flygut - An atlas of the Drosophila adult midgut

FBgn0024987

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31086

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3056

modMine - A data warehouse for the modENCODE project

FBgn0024987

Linkouts

BioGRID - A database of protein and genetic interactions.

57646

DPiM - Drosophila Protein interaction map

FBgn0024987

DroID - A comprehensive database of gene and protein interactions.

FBgn0024987

DRSC - Results frm RNAi screens

FBgn0024987

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0024987

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3056-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0024987

FlyMine - An integrated database for Drosophila genomics

FBgn0024987

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

31086

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG3056

(Çiçek et al., 2016, Horan et al., 2015, Izutsu et al., 2015, Khan et al., 2015, Christis and Munro, 2012, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Gempe and Beye, 2011, Ibrahim et al., 2011, Cline et al., 2010, Lunardi et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Lebo et al., 2009, Ayres et al., 2008, Sun and Cline, 2007, Traut et al., 2006)

EG:132E8.1

(Dorner et al., 2006, Giot et al., 2003, Benos et al., 2001)

Ssx

(Wei et al., 2020)

anon-EST:Posey102

cg3056

(Lasko, 2000)

ssx

(Moschall et al., 2019, Wang et al., 2018, Kwon et al., 2013, Kwon et al., 2013, Rodriguez et al., 2012, Cline et al., 2010)

Name Synonyms

sister-of-Sex-lethal

(Cline et al., 2010)

Secondary FlyBase IDs

FBgn0027771

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (61)

The following external sites may use different assemblies or annotations than FlyBase.

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