FlyBase Gene Report: Dmel\az2

General Information

Symbol

Dmel\az2

Species

D. melanogaster

Name

az2

Annotation Symbol

CG1605

Feature Type

protein_coding_gene

FlyBase ID

FBgn0025185

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

43D1-43D1

Sequence location

2R:7,510,622..7,512,749 [-]

Recombination map

2-56

RefSeq locus

NT_033778 REGION:7510622..7512749

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN000147941

(GO Reference Genome Project, 2011-)

enables DNA-binding transcription factor activity

inferred from sequence or structural similarity with FLYBASE:gl; FB:FBgn0004618

(McCormack et al., 1998)

enables RNA polymerase II transcription regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000147941

(GO Reference Genome Project, 2011-)

enables zinc ion binding

inferred from sequence model

(McCormack et al., 1998)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in regulation of DNA-templated transcription

inferred from sequence or structural similarity with FLYBASE:gl; FB:FBgn0004618

(McCormack et al., 1998)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000147941

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000147941

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\az2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q5BIC3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.48

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

az2-RA

FBtr0088980

NM_136445

2006

593

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

az2-PA

FBpp0088053

68.8

593

7.34

Q5BIC3

NP_610289

AAG22310

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\az2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

az2_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.06

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | faint | ubiquitous

(Fisher et al., 2012)

adult stage | female oogenesis stage S1 -- S10B

nurse cell

(McCormack et al., 1998)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

(McCormack et al., 1998)

ovary

(McCormack et al., 1998)

adult stage & oogenesis

(McCormack et al., 1998)

adult stage oogenesis stage S10B -- S14

oocyte

(McCormack et al., 1998)

Additional Descriptive Data

az2 transcript is detected during oogenesis. Expression is low in nurse cells in early oogenesis, but becomes abundant at stage S8 to S9. Starting at stage S10B, expression is detected in the oocyte.

(McCormack et al., 1998)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\az2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\az2

View exonic expression by tissue for Dmel\az2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025185

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35682/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0025185

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0025185

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0025185

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1605

Flygut - An atlas of the Drosophila adult midgut

FBgn0025185

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of az2

Transgenic constructs containing regulatory region of az2

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel6052

(Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (133)

Hsap\ZFP92

2 of 14

Yes

Hsap\ZNF84

2 of 14

Yes

Hsap\ZNF347

2 of 14

Yes

Hsap\BCL6

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZKSCAN8

1 of 14

Hsap\ZNF16

1 of 14

Hsap\ZNF34

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF160

1 of 14

Hsap\ZNF181

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF484

1 of 14

Hsap\ZNF486

1 of 14

Hsap\ZNF490

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF761

1 of 14

Hsap\ZNF764

1 of 14

Hsap\ZNF765-ZNF761

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\LOC100360380

1 of 14

Yes

Rnor\LOC100365363

1 of 14

Yes

Rnor\LOC102553962

1 of 14

Yes

Rnor\LOC102554302

1 of 14

Yes

Rnor\Zbtb48

1 of 14

Yes

Rnor\Zfp1

1 of 14

Yes

Rnor\Zfp26

1 of 14

Yes

Rnor\Zfp62

1 of 14

Yes

Rnor\Zfp74

1 of 14

Yes

Rnor\Zfp180

1 of 14

Yes

Rnor\Zfp212

1 of 14

Yes

Rnor\Zfp287

1 of 14

Yes

Rnor\Zfp334

1 of 14

Yes

Rnor\Zfp423

1 of 14

Yes

Rnor\Zfp449

1 of 14

Yes

Rnor\Zfp521

1 of 14

Yes

Rnor\Zfp560

1 of 14

Yes

Rnor\Zfp710

1 of 14

Yes

Rnor\Zfp764

1 of 14

Yes

Rnor\Znf48

1 of 14

Yes

Rnor\Znf354b

1 of 14

Yes

Mus musculus (laboratory mouse) (42)

Mmus\2610021A01Rik

1 of 14

Yes

Mmus\2610044O15Rik8

1 of 14

Yes

Mmus\E430018J23Rik

1 of 14

Yes

Mmus\Gm3604

1 of 14

Yes

Mmus\Gm4724

1 of 14

Yes

Mmus\Gm5141

1 of 14

Yes

Mmus\Gm14443

1 of 14

Yes

Mmus\Rsl1

1 of 14

Yes

Mmus\Zbtb48

1 of 14

Yes

Mmus\Zfp1

1 of 14

Yes

Mmus\Zfp26

1 of 14

Yes

Mmus\Zfp61

1 of 14

Yes

Mmus\Zfp62

1 of 14

Yes

Mmus\Zfp92

1 of 14

Yes

Mmus\Zfp93

1 of 14

Yes

Mmus\Zfp114

1 of 14

Yes

Mmus\Zfp142

1 of 14

Yes

Mmus\Zfp160

1 of 14

Yes

Mmus\Zfp212

1 of 14

Yes

Mmus\Zfp275

1 of 14

Yes

Mmus\Zfp287

1 of 14

Yes

Mmus\Zfp300

1 of 14

Yes

Mmus\Zfp334

1 of 14

Yes

Mmus\Zfp354b

1 of 14

Yes

Mmus\Zfp423

1 of 14

Yes

Mmus\Zfp449

1 of 14

Yes

Mmus\Zfp521

1 of 14

Yes

Mmus\Zfp553

1 of 14

Yes

Mmus\Zfp560

1 of 14

Yes

Mmus\Zfp688

1 of 14

Yes

Mmus\Zfp689

1 of 14

Yes

Mmus\Zfp710

1 of 14

Yes

Mmus\Zfp729b

1 of 14

Yes

Mmus\Zfp738

1 of 14

Yes

Mmus\Zfp764

1 of 14

Yes

Mmus\Zfp808

1 of 14

Yes

Mmus\Zfp934

1 of 14

Yes

Mmus\Zfp966

1 of 14

Yes

Mmus\Zfp967

1 of 14

Yes

Mmus\Zfp968

1 of 14

Yes

Mmus\Zfp969

1 of 14

Yes

Mmus\Zscan22

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (27)

Xtro\e4f1

1 of 13

Yes

Xtro\LOC496795

1 of 13

Yes

Xtro\LOC100489584

1 of 13

Yes

Xtro\LOC100493797

1 of 13

Yes

Xtro\LOC100498204

1 of 13

Yes

Xtro\LOC100498327

1 of 13

Yes

Xtro\LOC101732550

1 of 13

Yes

Xtro\LOC101733242

1 of 13

Yes

Xtro\LOC105947126

1 of 13

Yes

Xtro\LOC108648854

1 of 13

Yes

Xtro\parp6

1 of 13

Yes

Xtro\prdm15

1 of 13

Yes

Xtro\siah3

1 of 13

Yes

Xtro\snai1

1 of 13

Yes

Xtro\XB5795368

1 of 13

Yes

Xtro\zbtb11

1 of 13

Yes

Xtro\zbtb20

1 of 13

Yes

Xtro\zfp2

1 of 13

Yes

Xtro\znf177

1 of 13

Yes

Xtro\znf180

1 of 13

Yes

Xtro\znf229

1 of 13

Yes

Xtro\znf420

1 of 13

Yes

Xtro\znf423

1 of 13

Yes

Xtro\znf521

1 of 13

Yes

Xtro\znf526

1 of 13

Yes

Xtro\znf865

1 of 13

Yes

Xtro\znf883l

1 of 13

Yes

Danio rerio (Zebrafish) (55)

Drer\im:7141269

1 of 14

Yes

Drer\im:7147486

1 of 14

Yes

Drer\LOC797319

1 of 14

Yes

Drer\LOC100148466

1 of 14

Yes

Drer\LOC100330321

1 of 14

Yes

Drer\LOC100534672

1 of 14

Yes

Drer\LOC100536867

1 of 14

Yes

Drer\LOC100536922

1 of 14

Yes

Drer\LOC100537428

1 of 14

Yes

Drer\LOC101884367

1 of 14

Yes

Drer\LOC101885996

1 of 14

Yes

Drer\LOC101886111

1 of 14

Yes

Drer\LOC101886309

1 of 14

Yes

Drer\LOC103910773

1 of 14

Yes

Drer\LOC103910897

1 of 14

Yes

Drer\LOC108182171

1 of 14

Yes

Drer\LOC108182318

1 of 14

Yes

Drer\LOC108183688

1 of 14

Yes

Drer\LOC108183930

1 of 14

Yes

Drer\LOC110439557

1 of 14

Yes

Drer\si:cabz01069020.1

1 of 14

Yes

Drer\si:ch73-120g24.5

1 of 14

Yes

Drer\si:ch73-138e16.4

1 of 14

Yes

Drer\si:ch73-138e16.6

1 of 14

Yes

Drer\si:ch73-266f23.4

1 of 14

Yes

Drer\si:ch211-142b24.6

1 of 14

Yes

Drer\si:ch211-216l23.1

1 of 14

Yes

Drer\si:ch211-229l10.11

1 of 14

Yes

Drer\si:dkey-34m19.3

1 of 14

Yes

Drer\si:dkey-77f5.4

1 of 14

Yes

Drer\zbtb48

1 of 14

Yes

Drer\zgc:101562

1 of 14

Yes

Drer\zgc:113135

1 of 14

Yes

Drer\zgc:113294

1 of 14

Yes

Drer\zgc:113518

1 of 14

Yes

Drer\zgc:171673

1 of 14

Yes

Drer\zgc:171727

1 of 14

Yes

Drer\zgc:173615

1 of 14

Yes

Drer\zgc:174624

1 of 14

Yes

Drer\zgc:174653

1 of 14

Yes

Drer\znf142

1 of 14

Yes

Drer\znf423

1 of 14

Yes

Drer\znf521

1 of 14

Yes

Drer\znf521

1 of 14

Yes

Drer\znf526

1 of 14

Yes

Drer\znf576.2

1 of 14

Yes

Drer\znf648

1 of 14

Yes

Drer\znf982

1 of 14

Yes

Drer\znf989

1 of 14

Yes

Drer\znf1007

1 of 14

Yes

Drer\znf1010

1 of 14

Yes

Drer\znf1023

1 of 14

Yes

Drer\znf1040

1 of 14

Yes

Drer\znf1043

1 of 14

Yes

Drer\znf1113

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\mnm-2

2 of 14

Yes

Cele\blmp-1

1 of 14

Cele\C09F5.3

1 of 14

Cele\hinf-1

1 of 14

Anopheles gambiae (African malaria mosquito) (30)

Agam\AgaP_AGAP000286

1 of 12

Yes

Agam\AgaP_AGAP001132

1 of 12

Yes

Agam\AgaP_AGAP002074

1 of 12

Yes

Agam\AgaP_AGAP002497

1 of 12

Yes

Agam\AgaP_AGAP002615

1 of 12

Yes

Agam\AgaP_AGAP003594

1 of 12

Yes

Agam\AgaP_AGAP003991

1 of 12

Yes

Agam\AgaP_AGAP004174

1 of 12

Yes

Agam\AgaP_AGAP004259

1 of 12

Yes

Agam\AgaP_AGAP004590

1 of 12

Yes

Agam\AgaP_AGAP004651

1 of 12

Yes

Agam\AgaP_AGAP004764

1 of 12

Yes

Agam\AgaP_AGAP005274

1 of 12

Yes

Agam\AgaP_AGAP005479

1 of 12

Yes

Agam\AgaP_AGAP005659

1 of 12

Yes

Agam\AgaP_AGAP006701

1 of 12

Yes

Agam\AgaP_AGAP007389

1 of 12

Yes

Agam\AgaP_AGAP007514

1 of 12

Yes

Agam\AgaP_AGAP008971

1 of 12

Yes

Agam\AgaP_AGAP009025

1 of 12

Yes

Agam\AgaP_AGAP009068

1 of 12

Yes

Agam\AgaP_AGAP009130

1 of 12

Yes

Agam\AgaP_AGAP010501

1 of 12

Yes

Agam\AgaP_AGAP010751

1 of 12

Yes

Agam\AgaP_AGAP011410

1 of 12

Yes

Agam\AgaP_AGAP011759

1 of 12

Yes

Agam\AgaP_AGAP011844

1 of 12

Yes

Agam\AgaP_AGAP012074

1 of 12

Yes

Agam\AgaP_AGAP012410

1 of 12

Yes

Agam\AgaP_AGAP012768

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (29)

Atha\AT1G02030

1 of 13

Yes

Atha\AT1G26610

1 of 13

Yes

Atha\AT1G49900

1 of 13

Yes

Atha\AT2G28200

1 of 13

Yes

Atha\AT2G28710

1 of 13

Yes

Atha\AT2G45120

1 of 13

Yes

Atha\AT3G10470

1 of 13

Yes

Atha\AT3G29340

1 of 13

Yes

Atha\AT3G46070

1 of 13

Yes

Atha\AT3G46080

1 of 13

Yes

Atha\AT3G49930

1 of 13

Yes

Atha\AT3G53600

1 of 13

Yes

Atha\AT3G60580

1 of 13

Yes

Atha\AT4G04404

1 of 13

Yes

Atha\AT5G03510

1 of 13

Yes

Atha\AT5G04390

1 of 13

Yes

Atha\AT5G56200

1 of 13

Yes

Atha\AT5G61470

1 of 13

Yes

Atha\DAZ1

1 of 13

Yes

Atha\DAZ2

1 of 13

Yes

Atha\RHL41

1 of 13

Yes

Atha\STZ

1 of 13

Yes

Atha\YY1

1 of 13

Yes

Atha\ZAT6

1 of 13

Yes

Atha\ZAT7

1 of 13

Yes

Atha\ZAT11

1 of 13

Yes

Atha\ZF1

1 of 13

Yes

Atha\ZF2

1 of 13

Yes

Atha\ZF3

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\ZAP1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:az2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (65)

5 of 13

4 of 13

3 of 13

2 of 13

2 of 13

2 of 13

rgr

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

dwg

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

mld

1 of 13

Neu2

1 of 13

Opbp

1 of 13

Paris

1 of 13

Phs

1 of 13

pita

1 of 13

Plzf

1 of 13

pzg

1 of 13

Sry-β

1 of 13

wor

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

az2 - AIF

experimental knowledge based

(Guruharsha et al., 2011)

az2 - Ask1

experimental knowledge based

(Guruharsha et al., 2011)

az2 - B-H2

two hybrid array

(Shokri et al., 2019)

az2 - Bcs1

experimental knowledge based

(Guruharsha et al., 2011)

az2 - CG10494

experimental knowledge based

(Guruharsha et al., 2011)

az2 - CG1513

experimental knowledge based

(Guruharsha et al., 2011)

az2 - CG33523

experimental knowledge based

(Guruharsha et al., 2011)

az2 - CG9205

experimental knowledge based

(Guruharsha et al., 2011)

az2 - GAPcenA

experimental knowledge based

(Guruharsha et al., 2011)

az2 - Nup358

experimental knowledge based

(Guruharsha et al., 2011)

az2 - RanGAP

experimental knowledge based

(Guruharsha et al., 2011)

az2 - Sk2

experimental knowledge based

(Guruharsha et al., 2011)

az2 - Ubx

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

az2 - abd-A

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

az2 - cert

experimental knowledge based

(Guruharsha et al., 2011)

az2 - cliff

experimental knowledge based

(Guruharsha et al., 2011)

az2 - l(2)k01209

experimental knowledge based

(Guruharsha et al., 2011)

az2 - rdgB

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0025185

MIST (protein-protein) - An integrated Molecular Interaction Database

35682

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-56

Cytogenetic map

43D1-43D1

Sequence location

2R:7,510,622..7,512,749 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

43D1-43D1

Limits computationally determined from genome sequence between P{lacW}cos^k16101 and P{EP}CG1600^EP398

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

43C-43C

(McCahill, 1997.12.7)

43B-43C

(McCormack et al., 1998)

Experimentally Determined Recombination Data

Location

2-56

(FlyBase, 2016)

2-56.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

65292

w¹¹¹⁸; PBac{az2-GFP.FPTB}VK00033

26230

y¹ v¹; P{TRiP.JF02128}attP2

79933

y¹ sc^* v¹ sev²¹; P{TOE.GS02214}attP40

83977

y¹ sc^* v¹ sev²¹; P{TKO.GS04064}attP40

FlyORF

F003258

M{UAS-az2.ORF-CC}ZH-21F

F001693

M{UAS-az2.ORF.3xHA.GW}ZH-86Fb

NIG-Fly

1605R-2

P{NIG.1605R}2

2RG-0870

y² VhaAC39-1^cho-1 v¹; P{U6-az2.NIG.sgRNA}attP40/CyO

VDRC

v100150

P{KK105050}VIE-260B

v341510

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00581}attP40/CyO-GFP

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (13)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_SD02533

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0025185

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0025185

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

az2 has been cloned and sequenced.

(McCormack et al., 1998)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: az2 CG1605

(Gabrielian, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG1605

(National Institute of Genetics Fly Stocks, 2022-, Seinen et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31)

az2

(Shokri et al., 2019, Bischof et al., 2018, Transgenic RNAi Project members, 2017-, Schertel et al., 2015, Zhao et al., 2015, Japanese National Institute of Genetics, 2012.5.21)

zf43C

Name Synonyms

Zinc finger protein 43C

az2

Secondary FlyBase IDs

FBgn0022958

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35682

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q5BIC3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q5BIC3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025185

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35682/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0025185

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0025185

FlyMine - An integrated database for Drosophila genomics

FBgn0025185

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1605

MARRVEL_MODEL - MARRVEL (model organism gene)

35682

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0025185

DroID - A comprehensive database of gene and protein interactions.

FBgn0025185

DRSC - Results frm RNAi screens

FBgn0025185

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

az2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0025185

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0025185

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1605

Flygut - An atlas of the Drosophila adult midgut

FBgn0025185

MIST (protein-protein) - An integrated Molecular Interaction Database

35682

References (36)

The following external sites may use different assemblies or annotations than FlyBase.

-0.06

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