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Gene Dmel\CG4585

General Information
Symbol	Dmel\CG4585	Species	D. melanogaster
Name		Annotation symbol	CG4585
Feature type	protein_coding_gene	FlyBase ID	FBgn0025335
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60A5-60A5	Sequence location	2R:19,750,485..19,752,917 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG4585 (FBgn0025335). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: phosphotransferase activity, for other substituted phosphate groups. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: phospholipid biosynthetic process. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: CDP-alcohol phosphatidyltransferase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval midgut, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638874_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG4585. Gene sequence location is 2R:19750485..19752917.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60A5-60A5   Limits computationally determined from genome sequence between P{lacW}eIF6k13214 and P{lacW}kenk11035&P{EP}CG17658EP730
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60C-60C     (Lukacsovich, 1998.1.8)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG4585 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG4585-RA FBtr0072227  NM_058028   1730   392
Additional Transcript Data & Comments
Reported size (kB)	1.6 (northern blot) (Lukacsovich et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG4585-PA   FBpp0072136   43.9   392   8.21     NP_477376   AAF47081
Additional Polypeptide Data & Comments
Reported size (kDa)	392 (aa) (Lukacsovich et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • CDP-alcohol phosphatidyltransferase (IPR000462)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142132   AE013599 AAF47081   AB010261 BAA32689   AB010264 BAA32692   AC004347   AC005267   AI258766   AI294360   AI295090   AI297375   AI389194   AI389432   AW940777   AX094054   AY060752 AAL28300   BG635429   BG639607   BI142245   BI165391   BI172776   BI214128   BI215114   BQ103185   BQ103536   CK131870   CO156254   CO178964   CO185361   CO309785   CO311837   CO318400   CZ466271   CZ480457   EC056967   EC071901   EC195879   EC201982   EC227160   EC236924   EC264841   EV577913   EV579618   EV583688   EV584930   GH748294   GH748442   GH751465   GH752272   GH761073   GH771764   GH777092   GH777246   GH784324   GH791645   GH792152   GH795167   GH809705   GH811614   GH816942   GH819049   GH825668   GH830006   GH830756   GH831541   GH841061   GH842203   GH846793   GH847193   GH850528   GH859168   GH864197   GH865376   GH879412   GH883862   GH884178   GH885188   GH888063   GH894481   GH900778   GH903150   GH907409   GH916720   GH918862   GH925458   GH926173   GH926334   GH927287   GH938575   GH941039
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O77475
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval midgut, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    150.55 Larval Midgut    583 Larval Hindgut    390 Larval Malpighian Tubules    323.1 Larval Fat Body    226.1 Larval Salivary Gland    200 Larval Trachea    190.175 Larval Carcass    304.375 Adult Head    194.8 Adult Eye    245.55 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    184.6 Adult Crop    270.3 Adult Midgut    437.6 Adult Hindgut    394.4 Adult Malpighian Tubules    280.6 Adult Fat Body    367.1 Adult Salivary Gland    187.5 Adult Heart    398.25 Adult VirginFemale Spermatheca    475.9 Adult InseminatedFemale Spermatheca    371.4 Adult Ovary    611.6 Adult Testis    94.5 Adult Male Accessory Gland    178 Adult Carcass    264.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    150.55 Larval Midgut  (583) Larval Hindgut    390 Larval Malpighian Tubules    323.1 Larval Fat Body    226.1 Larval Salivary Gland    200 Larval Trachea    190.175 Larval Carcass    304.375 Adult Head    194.8 Adult Eye    245.55 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    184.6 Adult Crop    270.3 Adult Midgut    437.6 Adult Hindgut    394.4 Adult Malpighian Tubules    280.6 Adult Fat Body    367.1 Adult Salivary Gland    187.5 Adult Heart    398.25 Adult VirginFemale Spermatheca    475.9 Adult InseminatedFemale Spermatheca    371.4 Adult Ovary  (611.6) Adult Testis    94.5 Adult Male Accessory Gland    178 Adult Carcass    264.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    150.55 Larval Midgut    583 Larval Hindgut    390 Larval Malpighian Tubules    323.1 Larval Fat Body    226.1 Larval Salivary Gland    200 Larval Trachea    190.175 Larval Carcass    304.375 Adult Head    194.8 Adult Eye    245.55 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    184.6 Adult Crop    270.3 Adult Midgut    437.6 Adult Hindgut    394.4 Adult Malpighian Tubules    280.6 Adult Fat Body    367.1 Adult Salivary Gland    187.5 Adult Heart    398.25 Adult VirginFemale Spermatheca    475.9 Adult InseminatedFemale Spermatheca    371.4 Adult Ovary    611.6 Adult Testis    94.5 Adult Male Accessory Gland    178 Adult Carcass    264.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    150.55 Larval Midgut    583 Larval Hindgut    390 Larval Malpighian Tubules    323.1 Larval Fat Body    226.1 Larval Salivary Gland    200 Larval Trachea    190.175 Larval Carcass    304.375 Adult Head    194.8 Adult Eye    245.55 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    184.6 Adult Crop    270.3 Adult Midgut    437.6 Adult Hindgut    394.4 Adult Malpighian Tubules    280.6 Adult Fat Body    367.1 Adult Salivary Gland    187.5 Adult Heart    398.25 Adult VirginFemale Spermatheca    475.9 Adult InseminatedFemale Spermatheca    371.4 Adult Ovary    611.6 Adult Testis    94.5 Adult Male Accessory Gland    178 Adult Carcass    264.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    150.55 Larval Midgut    583 Larval Hindgut    390 Larval Malpighian Tubules    323.1 Larval Fat Body    226.1 Larval Salivary Gland    200 Larval Trachea    190.175 Larval Carcass    304.375 Adult Head    194.8 Adult Eye    245.55 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    184.6 Adult Crop    270.3 Adult Midgut    437.6 Adult Hindgut    394.4 Adult Malpighian Tubules    280.6 Adult Fat Body    367.1 Adult Salivary Gland    187.5 Adult Heart    398.25 Adult VirginFemale Spermatheca    475.9 Adult InseminatedFemale Spermatheca    371.4 Adult Ovary    611.6 Adult Testis    94.5 Adult Male Accessory Gland    178 Adult Carcass    264.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    150.55 Larval Midgut  583 Larval Hindgut    390 Larval Malpighian Tubules    323.1 Larval Fat Body    226.1 Larval Salivary Gland    200 Larval Trachea    190.175 Larval Carcass    304.375 Adult Head    194.8 Adult Eye    245.55 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    184.6 Adult Crop    270.3 Adult Midgut    437.6 Adult Hindgut    394.4 Adult Malpighian Tubules    280.6 Adult Fat Body    367.1 Adult Salivary Gland    187.5 Adult Heart    398.25 Adult VirginFemale Spermatheca    475.9 Adult InseminatedFemale Spermatheca    371.4 Adult Ovary  611.6 Adult Testis    94.5 Adult Male Accessory Gland    178 Adult Carcass    264.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    150.55 Larval Midgut    583 Larval Hindgut    390 Larval Malpighian Tubules    323.1 Larval Fat Body    226.1 Larval Salivary Gland    200 Larval Trachea    190.175 Larval Carcass    304.375 Adult Head    194.8 Adult Eye    245.55 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    184.6 Adult Crop    270.3 Adult Midgut    437.6 Adult Hindgut    394.4 Adult Malpighian Tubules    280.6 Adult Fat Body    367.1 Adult Salivary Gland    187.5 Adult Heart    398.25 Adult VirginFemale Spermatheca    475.9 Adult InseminatedFemale Spermatheca    371.4 Adult Ovary    611.6 Adult Testis    94.5 Adult Male Accessory Gland    178 Adult Carcass    264.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    150.55 Larval Midgut    583 Larval Hindgut    390 Larval Malpighian Tubules    323.1 Larval Fat Body    226.1 Larval Salivary Gland    200 Larval Trachea    190.175 Larval Carcass    304.375 Adult Head    194.8 Adult Eye    245.55 Adult Brain    172.1 Adult Thoracic-Abdominal Ganglion    184.6 Adult Crop    270.3 Adult Midgut    437.6 Adult Hindgut    394.4 Adult Malpighian Tubules    280.6 Adult Fat Body    367.1 Adult Salivary Gland    187.5 Adult Heart    398.25 Adult VirginFemale Spermatheca    475.9 Adult InseminatedFemale Spermatheca    371.4 Adult Ovary    611.6 Adult Testis    94.5 Adult Male Accessory Gland    178 Adult Carcass    264.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    194.8   NA  Eye    245.55   NA  Brain    172.1   150.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    184.6   NA  Crop    270.3   583  Midgut    437.6   390  Hindgut    394.4   323.1  Malpighian Tubules    280.6   226.1  Fat Body    367.1   200  Salivary Gland    187.5   NA  Heart    398.25   190.175  Trachea    NA   NA  VirginFemale Spermatheca    475.9   NA  InseminatedFemale Spermatheca    371.4   NA  Ovary    611.6   NA  Testis    94.5   NA  Male Accessory Gland    178   304.375  Carcass    264.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    26 digestive system, 4-day adult    17 digestive system, 20-day adult    28 fat body, larvae L3 wandering    5 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    13 ovary, virgin 4-day female    49 ovary, mated 4-day female    39 testis, mated 4-day male    14 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  (36) digestive system, 1-day adult  26 digestive system, 4-day adult    17 digestive system, 20-day adult  (28) fat body, larvae L3 wandering    5 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    13 ovary, virgin 4-day female  (49) ovary, mated 4-day female  (39) testis, mated 4-day male    14 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    26 digestive system, 4-day adult    17 digestive system, 20-day adult    28 fat body, larvae L3 wandering    5 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    13 ovary, virgin 4-day female    49 ovary, mated 4-day female    39 testis, mated 4-day male    14 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    26 digestive system, 4-day adult    17 digestive system, 20-day adult    28 fat body, larvae L3 wandering    5 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    13 ovary, virgin 4-day female    49 ovary, mated 4-day female    39 testis, mated 4-day male    14 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    26 digestive system, 4-day adult    17 digestive system, 20-day adult    28 fat body, larvae L3 wandering    5 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    13 ovary, virgin 4-day female    49 ovary, mated 4-day female    39 testis, mated 4-day male    14 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  (36) digestive system, 1-day adult  26 digestive system, 4-day adult    17 digestive system, 20-day adult  28 fat body, larvae L3 wandering    5 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    13 ovary, virgin 4-day female  (49) ovary, mated 4-day female  (39) testis, mated 4-day male    14 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    26 digestive system, 4-day adult    17 digestive system, 20-day adult    28 fat body, larvae L3 wandering    5 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    13 ovary, virgin 4-day female    49 ovary, mated 4-day female    39 testis, mated 4-day male    14 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    10 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    14 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    26 digestive system, 4-day adult    17 digestive system, 20-day adult    28 fat body, larvae L3 wandering    5 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    13 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    13 ovary, virgin 4-day female    49 ovary, mated 4-day female    39 testis, mated 4-day male    14 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    110 embryo 02-04hr    28 embryo 04-06hr    23 embryo 06-08hr    30 embryo 08-10hr    26 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    44 embryo 16-18hr    46 embryo 18-20hr    38 embryo 20-22hr    40 embryo 22-24hr    33 larva L1    42 larva L2    31 larva L3 12hr old    28 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    36 larva L3 puffstage 7-9    43 white prepupae new    47 white prepupae 12hr    25 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    16 pupae 4d postWPP    35 adult male 01day    29 adult male 05day    34 adult male 30day    41 adult female 01day    63 adult female 05day    68 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (110) embryo 02-04hr  (28) embryo 04-06hr    23 embryo 06-08hr  (30) embryo 08-10hr  26 embryo 10-12hr  (30) embryo 12-14hr    23 embryo 14-16hr  (44) embryo 16-18hr  (46) embryo 18-20hr  (38) embryo 20-22hr  (40) embryo 22-24hr  (33) larva L1  (42) larva L2  (31) larva L3 12hr old  (28) larva L3 puffstage 1-2  26 larva L3 puffstage 3-6  (36) larva L3 puffstage 7-9  (43) white prepupae new  (47) white prepupae 12hr    25 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    16 pupae 4d postWPP  (35) adult male 01day  (29) adult male 05day  (34) adult male 30day  (41) adult female 01day  (63) adult female 05day  (68) adult female 30day  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (110) embryo 02-04hr    28 embryo 04-06hr    23 embryo 06-08hr    30 embryo 08-10hr    26 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    44 embryo 16-18hr    46 embryo 18-20hr    38 embryo 20-22hr    40 embryo 22-24hr    33 larva L1    42 larva L2    31 larva L3 12hr old    28 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    36 larva L3 puffstage 7-9    43 white prepupae new    47 white prepupae 12hr    25 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    16 pupae 4d postWPP    35 adult male 01day    29 adult male 05day    34 adult male 30day    41 adult female 01day    63 adult female 05day    68 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    110 embryo 02-04hr    28 embryo 04-06hr    23 embryo 06-08hr    30 embryo 08-10hr    26 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    44 embryo 16-18hr    46 embryo 18-20hr    38 embryo 20-22hr    40 embryo 22-24hr    33 larva L1    42 larva L2    31 larva L3 12hr old    28 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    36 larva L3 puffstage 7-9    43 white prepupae new    47 white prepupae 12hr    25 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    16 pupae 4d postWPP    35 adult male 01day    29 adult male 05day    34 adult male 30day    41 adult female 01day    63 adult female 05day    68 adult female 30day    68 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    110 embryo 02-04hr    28 embryo 04-06hr    23 embryo 06-08hr    30 embryo 08-10hr    26 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    44 embryo 16-18hr    46 embryo 18-20hr    38 embryo 20-22hr    40 embryo 22-24hr    33 larva L1    42 larva L2    31 larva L3 12hr old    28 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    36 larva L3 puffstage 7-9    43 white prepupae new    47 white prepupae 12hr    25 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    16 pupae 4d postWPP    35 adult male 01day    29 adult male 05day    34 adult male 30day    41 adult female 01day    63 adult female 05day    68 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (110) embryo 02-04hr  28 embryo 04-06hr    23 embryo 06-08hr  30 embryo 08-10hr  26 embryo 10-12hr  30 embryo 12-14hr    23 embryo 14-16hr  (44) embryo 16-18hr  (46) embryo 18-20hr  (38) embryo 20-22hr  (40) embryo 22-24hr  (33) larva L1  (42) larva L2  31 larva L3 12hr old  28 larva L3 puffstage 1-2  26 larva L3 puffstage 3-6  (36) larva L3 puffstage 7-9  (43) white prepupae new  (47) white prepupae 12hr    25 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    16 pupae 4d postWPP  (35) adult male 01day  29 adult male 05day  (34) adult male 30day  (41) adult female 01day  (63) adult female 05day  (68) adult female 30day  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  110 embryo 02-04hr    28 embryo 04-06hr    23 embryo 06-08hr    30 embryo 08-10hr    26 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    44 embryo 16-18hr    46 embryo 18-20hr    38 embryo 20-22hr    40 embryo 22-24hr    33 larva L1    42 larva L2    31 larva L3 12hr old    28 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    36 larva L3 puffstage 7-9    43 white prepupae new    47 white prepupae 12hr    25 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    16 pupae 4d postWPP    35 adult male 01day    29 adult male 05day    34 adult male 30day    41 adult female 01day    63 adult female 05day    68 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    110 embryo 02-04hr    28 embryo 04-06hr    23 embryo 06-08hr    30 embryo 08-10hr    26 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    44 embryo 16-18hr    46 embryo 18-20hr    38 embryo 20-22hr    40 embryo 22-24hr    33 larva L1    42 larva L2    31 larva L3 12hr old    28 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    36 larva L3 puffstage 7-9    43 white prepupae new    47 white prepupae 12hr    25 white prepupae 24hr    19 pupae 2d postWPP    17 pupae 3d postWPP    16 pupae 4d postWPP    35 adult male 01day    29 adult male 05day    34 adult male 30day    41 adult female 01day    63 adult female 05day    68 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    33 embryonic 1182-4H    27 embryonic GM2    33 embryonic Kc167    14 embryonic S1    35 embryonic S3    29 leg disc CME L1    29 wing disc CME-W2    20 wing disc ML-DmD8    17 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    32 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (39) Schneider line 2 Sg4  (33) embryonic 1182-4H  (27) embryonic GM2  (33) embryonic Kc167    14 embryonic S1  (35) embryonic S3  (29) leg disc CME L1  (29) wing disc CME-W2    20 wing disc ML-DmD8    17 wing disc ML-DmD9  (31) wing disc ML-DmD16-c3  26 wing disc ML-DmD21  (29) wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5  (34) mixed discs ML-DmD4-c1  (27) CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2  (29) tumorous blood cells mbn2  (32) ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    33 embryonic 1182-4H    27 embryonic GM2    33 embryonic Kc167    14 embryonic S1    35 embryonic S3    29 leg disc CME L1    29 wing disc CME-W2    20 wing disc ML-DmD8    17 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    32 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    33 embryonic 1182-4H    27 embryonic GM2    33 embryonic Kc167    14 embryonic S1    35 embryonic S3    29 leg disc CME L1    29 wing disc CME-W2    20 wing disc ML-DmD8    17 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    32 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    33 embryonic 1182-4H    27 embryonic GM2    33 embryonic Kc167    14 embryonic S1    35 embryonic S3    29 leg disc CME L1    29 wing disc CME-W2    20 wing disc ML-DmD8    17 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    32 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (39) Schneider line 2 Sg4  (33) embryonic 1182-4H  27 embryonic GM2  (33) embryonic Kc167    14 embryonic S1  (35) embryonic S3  29 leg disc CME L1  29 wing disc CME-W2    20 wing disc ML-DmD8    17 wing disc ML-DmD9  31 wing disc ML-DmD16-c3  26 wing disc ML-DmD21  29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5  (34) mixed discs ML-DmD4-c1  27 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2  29 tumorous blood cells mbn2  32 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    33 embryonic 1182-4H    27 embryonic GM2    33 embryonic Kc167    14 embryonic S1    35 embryonic S3    29 leg disc CME L1    29 wing disc CME-W2    20 wing disc ML-DmD8    17 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    32 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    33 embryonic 1182-4H    27 embryonic GM2    33 embryonic Kc167    14 embryonic S1    35 embryonic S3    29 leg disc CME L1    29 wing disc CME-W2    20 wing disc ML-DmD8    17 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    34 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    32 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult  (27) Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  (32) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3  (54) Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (35) Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult  27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  32 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3  (54) Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (35) Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025335 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4585-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG4585GD2190 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG4585 Class Mutagen Stocks Known lesion CG4585c00207 piggyBac transposase 1 -- CG4585e02682 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG4585 Class Mutagen Stocks Known lesion CG4585GD2190 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG4585HM05273 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG4585KK111238 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2190} NA P{KK111238} NA P{TRiP.HM05273} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}CG4585c00207 NA PBac{RB}CG4585e02682 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
phosphotransferase activity, for other substituted phosphate groups inferred from electronic annotation with InterPro:IPR000462 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
phospholipid biosynthetic process inferred from electronic annotation with InterPro:IPR000462 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR000462 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG4585 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63375 DroID - A comprehensive database of gene and protein interactions. • FBgn0025335 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37782
Orthologs
OrthoDB Orthologs (19) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Z8ZGH Dipteran inclusive ortholog search EOG6FJ8JH Insect inclusive ortholog search EOG6TX9NK Arthropod inclusive ortholog search EOG6PRR6F Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6Z8ZGH)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG4585     Drosophila simulans   Dsim\GD25004 Y   Drosophila sechellia   Dsec\GM15501 Y   Drosophila erecta   Dere\GG19987 Y   Drosophila yakuba   Dyak\GE11520 Y   Drosophila ananassae   Dana\GF12061 Y   Drosophila persimilis   Dper\GL10926 Y   Drosophila willistoni   Dwil\GK19100 Y   Drosophila virilis   Dvir\GJ20460 Y   Drosophila mojavensis   Dmoj\GI20723 Y   Drosophila grimshawi   Dgri\GH20196 Y
Orthologs in non-Drosophila Dipterans (EOG6FJ8JH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008139   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014160   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017392
Orthologs in non-Dipteran Insects (EOG6TX9NK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43436   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004272   Solenopsis invicta Red fire ant  Sinv\SINV11893   Bombyx mori Silkmoth  Bmor\BGIBMGA000169
Orthologs in non-Insect Arthropods (EOG6PRR6F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW007695
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25004 Drosophila sechellia Dsec\GM15501 Drosophila erecta Dere\GG19987 Drosophila yakuba Dyak\GE11520 Drosophila ananassae Dana\GF12061 Drosophila pseudoobscura pseudoobscura Dpse\GA18277 Drosophila persimilis Dper\GL10926 Drosophila willistoni Dwil\GK19100 Drosophila virilis Dvir\GJ20460 Drosophila mojavensis Dmoj\GI20723 Drosophila grimshawi Dgri\GH20196
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	36103 y1 sc* v1; P{TRiP.HM05273}attP2
Harvard	- PBac{PB}CG4585c00207
VDRC	v102245 P{KK111238}VIE-260B v3593 w1118; P{GD2190}v3593 v3594 w1118; P{GD2190}v3594
Genomic Clones ( 1 )
	BACR05F24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 78 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH20310
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH20605 LP02039 LP07717 LP08615 LP11664 LP12907 RE05276 RE15449 RE19840 RE21331 SD03251 SD12838 SD16293
Other clones	9851 97222 103875 166714 527304 CK01.5B.G6 CK01.73C.E12 CK00282 Dmel_dig_004240_0586_1436 Dmel_dig_007492_0600_0444 Dmel_dig_008281_0650_2918 Dmel_dig_010840_0704_3042 EK008759 EK058050 EK219313 EK226947 EK271925 EN07647 RP003018832 RP003021375 RP003031904 RP003053862 RP003066730 RP003081856 RP003107654 RP003117968 RP003120355 RP003127969 RP003142242 RP003180147 RP003186372 RP003207134 RP003209144 RP003209465 RP003212378 RP003248003 RP003278235 RP003299953 RP003353969 RP003368218 RP003370512 RP003372568 RP003379699 RP003379809 RP003383019 RP003395062 RP003395597 RP003410052 RP003475801 RP003480595 RP003491818 RP003506498 RP003507661 RP003532287 RP003542668 RP003549874 RP003558084 RP003585010 RP003626594 RP003627580 RP003627963 RP003674734 RP003680778 UUGC0583
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025335 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37782
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: anon-60Ab CG4585 (Zhang, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Area matching Drosophila EST AA142132. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058028 RefSeq (Proteins) • NP_477376 DDBJ / EMBL / GenBank • AA142132 AAF47081 AAL28300 AB010261 AB010264 AC004347 AC005267 AI389194 AW940777 AX094054 AY060752 BAA32689 BAA32692 CZ466271 CZ480457 Entrez Gene - A searchable database of RefSeq genes. • 37782 UniProtKB/TrEMBL • O77475
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • CDP-alcohol phosphatidyltransferase (IPR000462)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63375 DroID - A comprehensive database of gene and protein interactions. • FBgn0025335 DRSC - Results from RNAi screens. • FBgn0025335 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025335 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4585-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025335 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37782 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37782 modMine - Data generated by the modENCODE project. • FBgn0025335
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	anon-60Ab   CG4585 (Ni et al., 2008, Lin et al., 2011, Keleman et al., 2009.8.5) CK00282 (Lukacsovich et al., 2003) UD2 (Lukacsovich et al., 1999) unnamed (Lukacsovich, 1998.1.8, Lukacsovich, 1998.1.8)
Name Synonym	undefined 2 (Lukacsovich et al., 1999)
Secondary FlyBase IDs
References ( 20 )
Research paper	Lin et al., 2011, PLoS ONE 6(6): e20371 Neuronal Function and Dysfunction of Drosophila dTDP. [FBrf0213971] Ni et al., 2008, Nat. Methods 5(1): 49--51 Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. [FBrf0200406] Lukacsovich et al., 2003, Arch. Insect Biochem. Physiol. 54(2): 77--94 The ken and barbie gene encoding a putative transcription factor with a BTB domain and three zinc finger motifs functions in terminalia development of Drosophila. [FBrf0167302] Lukacsovich et al., 1999, Genomics 57(1): 43--56 The Drosophila melanogaster 60A chromosomal division is extremely dense with functional genes: their sequences, genomic organization, and expression. [FBrf0108232]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file) Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Davies, 2001.3.15, GenBank/EMBL/DDBJ: AX094054 Sequence 178 from Patent WO0118547. [FBrf0149866] Lukacsovich, 1998.1.8, GenBank/EMBL/DDBJ: AB010264 Drosophila melanogaster mRNA at 60A locus in chromosome 2R, complete cds. [FBrf0117582] Lukacsovich, 1998.1.8, GenBank/EMBL/DDBJ: AB010261 Drosophila melanogaster genes at 60A locus in chromosome 2R. [FBrf0117580]
Curated genome annotation	Zhang, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0128766]
Patent	Davies et al., 2001, World Patent 0118547: Essential genes and assays relating thereto. [FBrf0199103]