SNF2-domain protein - inhibits replication fork progression to promote DNA underreplication - binds to H1 which is required for SuUR binding to chromatin in vivo - interacts with Rif1 which has a direct role in copy number control
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.54
There is only one protein coding transcript and one polypeptide associated with this gene
Interacts (via SNF2-like region) with Rif1.
The SNF2-like region is essential for localization to DNA replication forks and for promoting underreplication. It is not required for localization to heterochromatin.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SuUR using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\SuUR in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Su(UR)ES CG7869
One or more of the processed
transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping
Source for merge of Su(UR)ES CG7869 was sequence comparison ( date:000501 ).
DNA-protein interactions: genome-wide binding profile assayed for SuUR protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
Flies carrying four doses of SuUR+ show a considerable increase in ectopic conjugation in the polytene chromosomes compared to wild-type flies. Both the proportion of regions participating in conjugation and the number of chromosomes with numerous contact nodes are increased. As a result, chromosomes become twisted and wound and contain many loops or nodes. The number of weak points is increased compared to wild type.
Mutation in SuUR suppresses DNA underreplication in intercalary and pericentric heterochromatin of polytene chromosomes.