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Gene Dmel\CycT

General Information
Symbol	Dmel\CycT	Species	D. melanogaster
Name	Cyclin T	Annotation symbol	CG6292
Feature type	protein_coding_gene	FlyBase ID	FBgn0025455
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	P-TEFb
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	74D4-74D4	Sequence location	3L:17,544,013..17,550,888 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyclin T is referred to in FlyBase by the symbol Dmel\CycT (CG6292, FBgn0025455). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cyclin-dependent protein serine/threonine kinase regulator activity. There is experimental evidence that it is involved in the biological process: regulation of cell shape; transcription, DNA-dependent; response to heat; cell cycle; actin filament organization. 18 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Cyclin C/H/T/L; Cyclin T; Cyclin, N-terminal; Cyclin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1637897_at partially aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CycT: 13 out of 14 probes fall into this exonic region. Gene sequence location is 3L:17544013..17550888.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 74D4-74D4   Limits computationally determined from genome sequence between P{PZ}frc00073&P{PZ}frc02619 and P{lacW}l(3)j11B2j11B2
Experimentally Determined Cytological Location
Cytogenetic map Notes References 74E-74F     (Peng, 1998.3.2)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CycT for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CycT-RA FBtr0075206  NM_206395   3267   884 CycT-RB FBtr0075205  NM_079403   4305   1097 CycT-RC FBtr0333124  NM_001275063   5901   1097 CycT-RD FBtr0333125  NM_001275064   6132   884
Additional Transcript Data & Comments
Reported size (kB)	7.0, 5.5, 5.0 (northern blot) (Peng et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CycT-PA   FBpp0089275   94.6   884   10.29     NP_996117   AAS64974 CycT-PB   FBpp0074968   118.3   1097   10.08     NP_524127   AAF49325 CycT-PC   FBpp0305335   118.3   1097   10.08     NP_001261992   AGB94685 CycT-PD   FBpp0305336   94.6   884   10.29     NP_001261993   AGB94686
Additional Polypeptide Data & Comments
Reported size (kDa)	1097 (aa); 118 (kD predicted) (Peng et al., 1998) 124 (kD observed) (Marshall and Price, 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cyclin, N-terminal (IPR006671) Cyclin-like (IPR013763) Cyclin C/H/T/L (IPR015429) Cyclin T (IPR015430)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439060   AA540069   AA698878   AA816737   AA990710   AE014296 AAF49325   AE014296 AAS64974   AF051933 AAC73052   AE014296 AGB94685   AE014296 AGB94686   AI133996   AI517680   AI519459   AI542278   AI546599   AW941101   AY075353   AY089251   BF486499   BF489989   BF493408   BF494012   BF494056   BF494276   BF494730   BF497513   BF501765   BF502199   BF502910   BF503619   BF505414   BG631979   BG634291   BG634601   BG638739   BG638936   BI355735   BI358620   BI637969   BQ102677   BT024941   BT057973   CO178362   CO185418   CO185696   CO186735   CO268527   CO279725   CO282126   CO289207   CO291530   CO300075   CO303754   CO316865   CO320472   CO325965   CO331058   CO331800   CO335661   CO338190   CO339057   CO339671   CO342237   CO344797   CO345328   CZ469497   CZ470491   CZ470819   CZ470981   CZ470982   EC053217   EC053329   EC073515   EC074959   EC078012   EC080286   EC195826   EC196314   EC198161   EC198347   EC210372   EC216539   EC227985   EC239194   EC240472   EC240770   EC243001   EC244352   EC245666   EC253039   EC256349   EC256430   EC256761   EC258688   EC259431   EC262254   EC266198   EL884921   EL885046   EL885168   ES689837   EV584204   EV597256   GH942111   GH942685   GH943415   GH945403   GH948389   GH954113   GH964960   GH969232   GH970828   GH984651
UniProtKB/Swiss-Prot	O96433
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   anterior endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi organism | gap expression pattern   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
ELL-EAF complex inferred from physical interaction with Su(Tpl) (Smith et al., 2011) nucleus inferred from direct assay (Lis et al., 2000) polytene chromosome inferred from direct assay (Lis et al., 2000) polytene chromosome puff inferred from direct assay (Lis et al., 2000) positive transcription elongation factor complex b inferred from physical interaction with Cdk9 (Peng et al., 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    30.675 Larval Midgut    27.5 Larval Hindgut    47.7 Larval Malpighian Tubules    41.4 Larval Fat Body    59.4 Larval Salivary Gland    46.1 Larval Trachea    67.275 Larval Carcass    27.575 Adult Head    23.3 Adult Eye    68.525 Adult Brain    58.4 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    35.4 Adult Midgut    22 Adult Hindgut    29.7 Adult Malpighian Tubules    31.2 Adult Fat Body    36.3 Adult Salivary Gland    45.3 Adult Heart    54.975 Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    340.1 Adult Testis    331.5 Adult Male Accessory Gland    39.5 Adult Carcass    35 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    30.675 Larval Midgut    27.5 Larval Hindgut    47.7 Larval Malpighian Tubules    41.4 Larval Fat Body    59.4 Larval Salivary Gland    46.1 Larval Trachea    67.275 Larval Carcass    27.575 Adult Head    23.3 Adult Eye    68.525 Adult Brain    58.4 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    35.4 Adult Midgut    22 Adult Hindgut    29.7 Adult Malpighian Tubules    31.2 Adult Fat Body    36.3 Adult Salivary Gland    45.3 Adult Heart    54.975 Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    340.1 Adult Testis    331.5 Adult Male Accessory Gland    39.5 Adult Carcass    35 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    30.675 Larval Midgut    27.5 Larval Hindgut    47.7 Larval Malpighian Tubules    41.4 Larval Fat Body    59.4 Larval Salivary Gland    46.1 Larval Trachea    67.275 Larval Carcass    27.575 Adult Head    23.3 Adult Eye    68.525 Adult Brain    58.4 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    35.4 Adult Midgut    22 Adult Hindgut    29.7 Adult Malpighian Tubules    31.2 Adult Fat Body    36.3 Adult Salivary Gland    45.3 Adult Heart    54.975 Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    340.1 Adult Testis    331.5 Adult Male Accessory Gland    39.5 Adult Carcass    35 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    30.675 Larval Midgut    27.5 Larval Hindgut    47.7 Larval Malpighian Tubules    41.4 Larval Fat Body    59.4 Larval Salivary Gland    46.1 Larval Trachea    67.275 Larval Carcass    27.575 Adult Head    23.3 Adult Eye    68.525 Adult Brain    58.4 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    35.4 Adult Midgut    22 Adult Hindgut    29.7 Adult Malpighian Tubules    31.2 Adult Fat Body    36.3 Adult Salivary Gland    45.3 Adult Heart    54.975 Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    340.1 Adult Testis    331.5 Adult Male Accessory Gland    39.5 Adult Carcass    35 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    30.675 Larval Midgut    27.5 Larval Hindgut    47.7 Larval Malpighian Tubules    41.4 Larval Fat Body    59.4 Larval Salivary Gland    46.1 Larval Trachea    67.275 Larval Carcass    27.575 Adult Head    23.3 Adult Eye    68.525 Adult Brain    58.4 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    35.4 Adult Midgut    22 Adult Hindgut    29.7 Adult Malpighian Tubules    31.2 Adult Fat Body    36.3 Adult Salivary Gland    45.3 Adult Heart    54.975 Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    340.1 Adult Testis    331.5 Adult Male Accessory Gland    39.5 Adult Carcass    35 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    30.675 Larval Midgut    27.5 Larval Hindgut    47.7 Larval Malpighian Tubules    41.4 Larval Fat Body    59.4 Larval Salivary Gland    46.1 Larval Trachea    67.275 Larval Carcass    27.575 Adult Head    23.3 Adult Eye    68.525 Adult Brain    58.4 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    35.4 Adult Midgut    22 Adult Hindgut    29.7 Adult Malpighian Tubules    31.2 Adult Fat Body    36.3 Adult Salivary Gland    45.3 Adult Heart    54.975 Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    340.1 Adult Testis    331.5 Adult Male Accessory Gland    39.5 Adult Carcass    35 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    30.675 Larval Midgut    27.5 Larval Hindgut    47.7 Larval Malpighian Tubules    41.4 Larval Fat Body    59.4 Larval Salivary Gland    46.1 Larval Trachea    67.275 Larval Carcass    27.575 Adult Head    23.3 Adult Eye    68.525 Adult Brain    58.4 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    35.4 Adult Midgut    22 Adult Hindgut    29.7 Adult Malpighian Tubules    31.2 Adult Fat Body    36.3 Adult Salivary Gland    45.3 Adult Heart    54.975 Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    340.1 Adult Testis    331.5 Adult Male Accessory Gland    39.5 Adult Carcass    35 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    30.675 Larval Midgut    27.5 Larval Hindgut    47.7 Larval Malpighian Tubules    41.4 Larval Fat Body    59.4 Larval Salivary Gland    46.1 Larval Trachea    67.275 Larval Carcass    27.575 Adult Head    23.3 Adult Eye    68.525 Adult Brain    58.4 Adult Thoracic-Abdominal Ganglion    36.8 Adult Crop    35.4 Adult Midgut    22 Adult Hindgut    29.7 Adult Malpighian Tubules    31.2 Adult Fat Body    36.3 Adult Salivary Gland    45.3 Adult Heart    54.975 Adult VirginFemale Spermatheca    24.6 Adult InseminatedFemale Spermatheca    22.5 Adult Ovary    340.1 Adult Testis    331.5 Adult Male Accessory Gland    39.5 Adult Carcass    35 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    23.3   NA  Eye    68.525   NA  Brain    58.4   30.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    36.8   NA  Crop    35.4   27.5  Midgut    22   47.7  Hindgut    29.7   41.4  Malpighian Tubules    31.2   59.4  Fat Body    36.3   46.1  Salivary Gland    45.3   NA  Heart    54.975   67.275  Trachea    NA   NA  VirginFemale Spermatheca    24.6   NA  InseminatedFemale Spermatheca    22.5   NA  Ovary    340.1   NA  Testis    331.5   NA  Male Accessory Gland    39.5   27.575  Carcass    35 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    57 central nervous system, larvae L3    38 central nervous system, pupae P8    31 head, virgin 1-day female    18 head, virgin 4-day female    21 head, virgin 20-day female    14 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male    27 head, mated 4-day male    35 head, mated 20-day male    32 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    9 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    20 carcass, larvae L3 wandering    27 carcass, 1-day adult    14 carcass, 4-day adult    20 carcass, 20-day adult    14 ovary, virgin 4-day female    67 ovary, mated 4-day female    83 testis, mated 4-day male    51 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (57) central nervous system, larvae L3  (38) central nervous system, pupae P8  (31) head, virgin 1-day female    18 head, virgin 4-day female    21 head, virgin 20-day female    14 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male  (27) head, mated 4-day male  (35) head, mated 20-day male  (32) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    9 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    20 carcass, larvae L3 wandering  (27) carcass, 1-day adult    14 carcass, 4-day adult    20 carcass, 20-day adult    14 ovary, virgin 4-day female  (67) ovary, mated 4-day female  (83) testis, mated 4-day male  (51) accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    57 central nervous system, larvae L3    38 central nervous system, pupae P8    31 head, virgin 1-day female    18 head, virgin 4-day female    21 head, virgin 20-day female    14 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male    27 head, mated 4-day male    35 head, mated 20-day male    32 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    9 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    20 carcass, larvae L3 wandering    27 carcass, 1-day adult    14 carcass, 4-day adult    20 carcass, 20-day adult    14 ovary, virgin 4-day female    67 ovary, mated 4-day female    83 testis, mated 4-day male    51 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    57 central nervous system, larvae L3    38 central nervous system, pupae P8    31 head, virgin 1-day female    18 head, virgin 4-day female    21 head, virgin 20-day female    14 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male    27 head, mated 4-day male    35 head, mated 20-day male    32 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    9 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    20 carcass, larvae L3 wandering    27 carcass, 1-day adult    14 carcass, 4-day adult    20 carcass, 20-day adult    14 ovary, virgin 4-day female    67 ovary, mated 4-day female    83 testis, mated 4-day male    51 accessory gland, mated 4-day male    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    57 central nervous system, larvae L3    38 central nervous system, pupae P8    31 head, virgin 1-day female    18 head, virgin 4-day female    21 head, virgin 20-day female    14 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male    27 head, mated 4-day male    35 head, mated 20-day male    32 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    9 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    20 carcass, larvae L3 wandering    27 carcass, 1-day adult    14 carcass, 4-day adult    20 carcass, 20-day adult    14 ovary, virgin 4-day female    67 ovary, mated 4-day female    83 testis, mated 4-day male    51 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (57) central nervous system, larvae L3  (38) central nervous system, pupae P8  31 head, virgin 1-day female    18 head, virgin 4-day female    21 head, virgin 20-day female    14 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male  27 head, mated 4-day male  (35) head, mated 20-day male  32 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    9 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    20 carcass, larvae L3 wandering  27 carcass, 1-day adult    14 carcass, 4-day adult    20 carcass, 20-day adult    14 ovary, virgin 4-day female  (67) ovary, mated 4-day female  (83) testis, mated 4-day male  (51) accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    57 central nervous system, larvae L3    38 central nervous system, pupae P8    31 head, virgin 1-day female    18 head, virgin 4-day female    21 head, virgin 20-day female    14 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male    27 head, mated 4-day male    35 head, mated 20-day male    32 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    9 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    20 carcass, larvae L3 wandering    27 carcass, 1-day adult    14 carcass, 4-day adult    20 carcass, 20-day adult    14 ovary, virgin 4-day female    67 ovary, mated 4-day female    83 testis, mated 4-day male    51 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    57 central nervous system, larvae L3    38 central nervous system, pupae P8    31 head, virgin 1-day female    18 head, virgin 4-day female    21 head, virgin 20-day female    14 head, mated 1-day female    25 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male    27 head, mated 4-day male    35 head, mated 20-day male    32 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    9 digestive system, 4-day adult    19 digestive system, 20-day adult    11 fat body, larvae L3 wandering    9 fat body, white prepupae    22 fat body, pupae P8    20 carcass, larvae L3 wandering    27 carcass, 1-day adult    14 carcass, 4-day adult    20 carcass, 20-day adult    14 ovary, virgin 4-day female    67 ovary, mated 4-day female    83 testis, mated 4-day male    51 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    31 embryo 04-06hr    27 embryo 06-08hr    25 embryo 08-10hr    19 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    12 embryo 16-18hr    11 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    15 pupae 4d postWPP    15 adult male 01day    20 adult male 05day    26 adult male 30day    23 adult female 01day    19 adult female 05day    30 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (45) embryo 02-04hr  (31) embryo 04-06hr  (27) embryo 06-08hr    25 embryo 08-10hr    19 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    12 embryo 16-18hr    11 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    15 pupae 4d postWPP    15 adult male 01day    20 adult male 05day  26 adult male 30day    23 adult female 01day    19 adult female 05day  (30) adult female 30day  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    31 embryo 04-06hr    27 embryo 06-08hr    25 embryo 08-10hr    19 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    12 embryo 16-18hr    11 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    15 pupae 4d postWPP    15 adult male 01day    20 adult male 05day    26 adult male 30day    23 adult female 01day    19 adult female 05day    30 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    31 embryo 04-06hr    27 embryo 06-08hr    25 embryo 08-10hr    19 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    12 embryo 16-18hr    11 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    15 pupae 4d postWPP    15 adult male 01day    20 adult male 05day    26 adult male 30day    23 adult female 01day    19 adult female 05day    30 adult female 30day    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    31 embryo 04-06hr    27 embryo 06-08hr    25 embryo 08-10hr    19 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    12 embryo 16-18hr    11 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    15 pupae 4d postWPP    15 adult male 01day    20 adult male 05day    26 adult male 30day    23 adult female 01day    19 adult female 05day    30 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (45) embryo 02-04hr  31 embryo 04-06hr  27 embryo 06-08hr    25 embryo 08-10hr    19 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    12 embryo 16-18hr    11 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    15 pupae 4d postWPP    15 adult male 01day    20 adult male 05day  26 adult male 30day    23 adult female 01day    19 adult female 05day  30 adult female 30day  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    31 embryo 04-06hr    27 embryo 06-08hr    25 embryo 08-10hr    19 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    12 embryo 16-18hr    11 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    15 pupae 4d postWPP    15 adult male 01day    20 adult male 05day    26 adult male 30day    23 adult female 01day    19 adult female 05day    30 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    31 embryo 04-06hr    27 embryo 06-08hr    25 embryo 08-10hr    19 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    12 embryo 16-18hr    11 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    15 pupae 4d postWPP    15 adult male 01day    20 adult male 05day    26 adult male 30day    23 adult female 01day    19 adult female 05day    30 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    36 Schneider line 2 Sg4    16 embryonic 1182-4H    36 embryonic GM2    51 embryonic Kc167    28 embryonic S1    40 embryonic S3    25 leg disc CME L1    28 wing disc CME-W2    22 wing disc ML-DmD8    27 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    7 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    31 ovary fGS/OSS    107 ovary OSC    80 ovary OSS    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (36) Schneider line 2 Sg4    16 embryonic 1182-4H  (36) embryonic GM2  (51) embryonic Kc167  (28) embryonic S1  (40) embryonic S3    25 leg disc CME L1  (28) wing disc CME-W2    22 wing disc ML-DmD8  (27) wing disc ML-DmD9  (39) wing disc ML-DmD16-c3  (35) wing disc ML-DmD21    7 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3  (32) eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1  (36) CNS ML-DmBG2-c2    22 tumorous blood cells mbn2  (31) ovary fGS/OSS  (107) ovary OSC  (80) ovary OSS  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    36 Schneider line 2 Sg4    16 embryonic 1182-4H    36 embryonic GM2    51 embryonic Kc167    28 embryonic S1    40 embryonic S3    25 leg disc CME L1    28 wing disc CME-W2    22 wing disc ML-DmD8    27 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    7 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    31 ovary fGS/OSS  107 ovary OSC    80 ovary OSS    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    36 Schneider line 2 Sg4    16 embryonic 1182-4H    36 embryonic GM2    51 embryonic Kc167    28 embryonic S1    40 embryonic S3    25 leg disc CME L1    28 wing disc CME-W2    22 wing disc ML-DmD8    27 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    7 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    31 ovary fGS/OSS    107 ovary OSC    80 ovary OSS    55 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    36 Schneider line 2 Sg4    16 embryonic 1182-4H    36 embryonic GM2    51 embryonic Kc167    28 embryonic S1    40 embryonic S3    25 leg disc CME L1    28 wing disc CME-W2    22 wing disc ML-DmD8    27 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    7 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    31 ovary fGS/OSS    107 ovary OSC    80 ovary OSS    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (36) Schneider line 2 Sg4    16 embryonic 1182-4H  (36) embryonic GM2  (51) embryonic Kc167  28 embryonic S1  (40) embryonic S3    25 leg disc CME L1  28 wing disc CME-W2    22 wing disc ML-DmD8  27 wing disc ML-DmD9  (39) wing disc ML-DmD16-c3  (35) wing disc ML-DmD21    7 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3  32 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1  (36) CNS ML-DmBG2-c2    22 tumorous blood cells mbn2  31 ovary fGS/OSS  (107) ovary OSC  (80) ovary OSS  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    36 Schneider line 2 Sg4    16 embryonic 1182-4H    36 embryonic GM2    51 embryonic Kc167    28 embryonic S1    40 embryonic S3    25 leg disc CME L1    28 wing disc CME-W2    22 wing disc ML-DmD8    27 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    7 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    31 ovary fGS/OSS  107 ovary OSC    80 ovary OSS    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    36 Schneider line 2 Sg4    16 embryonic 1182-4H    36 embryonic GM2    51 embryonic Kc167    28 embryonic S1    40 embryonic S3    25 leg disc CME L1    28 wing disc CME-W2    22 wing disc ML-DmD8    27 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    7 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    31 ovary fGS/OSS    107 ovary OSC    80 ovary OSS    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    23 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    72 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    69 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    41 Ethanol 2.5% 3 hrs, larvae L3    55 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (35) cold shock, 4-day adult    23 heat shock, 4-day adult  (32) Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult  (31) Cadmium 100 mM 48 hrs, 4-day adult  (72) Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult  (69) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult  (41) Ethanol 2.5% 3 hrs, larvae L3  (55) Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (59) Caffeine 25 mg/ml 48 hrs, 4-day adult  (40) Paraquat 5 mM 48 hrs, 4-day adult  (52) Paraquat 10 mM 48 hrs, 4-day adult  (43) Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    23 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    72 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    69 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    41 Ethanol 2.5% 3 hrs, larvae L3    55 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    23 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    72 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    69 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    41 Ethanol 2.5% 3 hrs, larvae L3    55 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    23 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    72 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    69 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    41 Ethanol 2.5% 3 hrs, larvae L3    55 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (35) cold shock, 4-day adult    23 heat shock, 4-day adult  32 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult  31 Cadmium 100 mM 48 hrs, 4-day adult  (72) Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult  (69) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult  (41) Ethanol 2.5% 3 hrs, larvae L3  (55) Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (59) Caffeine 25 mg/ml 48 hrs, 4-day adult  (40) Paraquat 5 mM 48 hrs, 4-day adult  (52) Paraquat 10 mM 48 hrs, 4-day adult  (43) Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    23 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    72 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    69 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    41 Ethanol 2.5% 3 hrs, larvae L3    55 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    23 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    72 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    69 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    41 Ethanol 2.5% 3 hrs, larvae L3    55 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_21 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • AT03646 GH28728 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025455 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6292-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CycT Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 CycTGD4130 Phenotype manifest in Allele
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of CycT Class Mutagen Stocks Known lesion CycT5-HA-2393 1 -- CycTc04764 piggyBac transposase 1 -- CycTc06091 piggyBac transposase 1 -- CycTc06571 piggyBac transposase 1 -- CycTMI04468 1 -- CycTc06766 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CycT Class Mutagen Stocks Known lesion CycTGD4130 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CycTGL00037 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CycTHM04074 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CycTHMS00776 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CycTKK100386 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CycT2xMut.MtnA.T:Scer\GAL4 in vitro construct - amino acid replacement 0 Yes CycTdsRNA.cNa in vitro construct - RNAi 0 Yes CycTMtnA.PL in vitro construct - regulatory fusion 0 Yes CycTMtnA.T:Scer\GAL4 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CycTNIG.6292R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CycTnos.3'UTR.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes CycTScer\UAS.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel9005 (Ryder, 2004.4.26) Df(3R)ED4688 (Keleman et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4130} NA P{KK100386} NA P{NIG.6292R} NA P{TRiP.GL00037} NA P{TRiP.HM04074} NA P{TRiP.HMS00776} NA P{UAS-mRFP-CycT} NA P{UASp-CycT.nos-3'UTR} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}CycTMI04468 NA P{RS5}CycT5-HA-2393 NA PBac{PB}CycTc04764 NA PBac{PB}CycTc06091 NA PBac{PB}CycTc06571 NA PBac{PB}CycTc06766 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Kiger et al., 2003) cell cycle inferred from mutant phenotype (Kiger et al., 2003) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003) response to heat inferred from direct assay (Lis et al., 2000) transcription, DNA-dependent inferred from direct assay (Lis et al., 2000)
Cellular Component
CV term Evidence References
ELL-EAF complex inferred from physical interaction with Su(Tpl) (Smith et al., 2011) nucleus inferred from direct assay (Lis et al., 2000) polytene chromosome inferred from direct assay (Lis et al., 2000) polytene chromosome puff inferred from direct assay (Lis et al., 2000) positive transcription elongation factor complex b inferred from physical interaction with Cdk9 (Peng et al., 1998)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
cyclin-dependent protein serine/threonine kinase regulator activity inferred from sequence or structural similarity with EMBL:AF048732 (FlyBase, 1992-) inferred from sequence or structural similarity with CycC AND inferred from sequence or structural similarity with CycH (Peng et al., 1998) protein kinase binding inferred from electronic annotation with InterPro:IPR015429, InterPro:IPR015430 (FlyBase Curators et al., 2004-) RNA polymerase II carboxy-terminal domain kinase activity traceable author statement (Lis et al., 2000)
Biological Process
CV term Evidence References
regulation of cyclin-dependent protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR015429 (FlyBase Curators et al., 2004-) regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR015429, InterPro:IPR015430 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
positive transcription elongation factor complex b traceable author statement (Lis et al., 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CycT - CG17601 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CycT - Cdk9 experimental knowledge based (Guruharsha et al., 2011) CycT - Hexim anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting (Nguyen et al., 2012, Mintseris et al., 2009.11.23) CycT - Larp7 anti bait coimmunoprecipitation, western blot (Nguyen et al., 2012) CycT - Su(Tpl) anti tag coimmunoprecipitation, peptide massfingerprinting (Smith et al., 2011)
RNA-protein
Interacting group Assay References
CycT - snRNA:7SK anti bait coimmunoprecipitation, nothern blot (Nguyen et al., 2012)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CycT allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65249 DroID - A comprehensive database of gene and protein interactions. • FBgn0025455 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39961 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O96433
Orthologs
OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6MKP1P Dipteran inclusive ortholog search EOG6907J1 Insect inclusive ortholog search EOG62JMMC Arthropod inclusive ortholog search EOG6XWDCR Metazoa inclusive ortholog search EOG6QP0P0
Orthologs in Drosophila Species (EOG6MKP1P)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CycT     Drosophila simulans   Dsim\GD12396 Y   Drosophila sechellia   Dsec\GM24323 Y   Drosophila erecta   Dere\GG15801 Y   Drosophila yakuba   Dyak\GE22136 Y   Drosophila ananassae   Dana\GF23902 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19492 Y   Drosophila persimilis   Dper\GL25034 Y   Drosophila willistoni   Dwil\GK17011 Y   Drosophila virilis   Dvir\GJ13100 Y   Drosophila mojavensis   Dmoj\GI12957 Y   Drosophila grimshawi   Dgri\GH15353 Y
Orthologs in non-Drosophila Dipterans (EOG6907J1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004839   Anopheles gambiae Malaria mosquito  Agam\AGAP006678   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012914
Orthologs in non-Dipteran Insects (EOG62JMMC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\CycT   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005239   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22216   Atta cephalotes Leafcutter ant  Acep\ACEP17624   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20043   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17993   Linepithema humile Argentine ant  Lhum\LH15241   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23083   Solenopsis invicta Red fire ant  Sinv\SINV13319   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002126   Bombyx mori Silkmoth  Bmor\BGIBMGA009664   Pediculus humanus Human body louse  Phum\PHUM065490
Orthologs in non-Insect Arthropods (EOG6XWDCR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Gng7   Ixodes scapularis Deer tick  Isca\ISCW018295
Orthologs in non-Arthropod Metazoa (EOG6QP0P0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cit-1.2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021812gn   Danio rerio Zebrafish  Drer\ccnt2a   Danio rerio Zebrafish  Drer\si:dkey-18f23.10   Danio rerio Zebrafish  Drer\ccnt2b   Xenopus tropicalis Western clawed frog  Xtro\ccnt2   Xenopus tropicalis Western clawed frog  Xtro\ccnt1   Gallus gallus Domestic chicken  Ggal\CCNT2   Mus musculus House mouse  Mmus\Ccnt1   Mus musculus House mouse  Mmus\Ccnt2   Rattus norvegicus Norway rat  Rnor\Ccnt1   Rattus norvegicus Norway rat  Rnor\Ccnt2   Homo sapiens Human  Hsap\CCNT1   Homo sapiens Human  Hsap\ENSG00000082258
Human Orthologs (2)
Gene OMIM HGNC Hsap\CCNT1     Hsap\ENSG00000082258
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12396 Drosophila sechellia Dsec\GM24323 Drosophila erecta Dere\GG15801 Drosophila yakuba Dyak\GE22136 Drosophila ananassae Dana\GF23902 Drosophila pseudoobscura pseudoobscura Dpse\GA19492 Drosophila persimilis Dper\GL25034 Drosophila willistoni Dwil\GK17011 Drosophila virilis Dvir\GJ13100 Drosophila mojavensis Dmoj\GI12957 Drosophila grimshawi Dgri\GH15353
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	31762 y1 v1; P{TRiP.HM04074}attP2 37678 y1 w*; Mi{MIC}CycTMI04468 35168 y1 sc* v1; P{TRiP.GL00037}attP2 32976 y1 sc* v1; P{TRiP.HMS00776}attP2
Harvard	- PBac{PB}CycTc04764 - PBac{PB}CycTc06091 - PBac{PB}CycTc06571
Kyoto	125610 w1118; P{RS5}CycT5-HA-2393
VDRC	v103387 P{KK100386}VIE-260B v37562 w1118; P{GD4130}v37562/CyO
Genomic Clones ( 1 )
	BACR44K07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 98 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT03646 AT19807 GH28728 IP16034
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01728 AT02415 AT02465 AT02722 AT03454 AT04704 AT07636 AT11695 AT17311 AT17855 AT18764 AT20820 AT26248 AT26778 AT30449 AT30859 GH11325 GM27514 GM32137 HL05850 LD05122 LD13506 LD19420 SD08045 SD08521 SD20183
Other clones	12921 28012 31412 34930 44331 51384 70137 161915 179131 194188 214219.43 214257.55 214281.48 214403.54 214535.56 214541.41 274268 542599 571134 CK01.8A.E3 CK01.24C.E6 CK01.25B.F2 CK01.71B.F11 CK01.90C.D2 CK01.120B.C6 Dmel_dig_005839_0615_3433 Dmel_neb_013026_0881_1524 EC053217 EC053329 EK009305 EK010918 EK022553 EK056524 EK070445 EK091843 EK135741 EK159604 EK177335 EK197560 EK242704 EK266059 EK285617 EK297364 EK301730 EN10932 EN16143 EP00710 EP02511 EP02964 EP14247 EP19917 EP21834 IP16134 IP16234 IP16334 LD34545 LD39065 RP004119052 RP004195992 RP004196057 RP004231342 RP004252905 RP004257951 RP004259763 RP004421719 RP004444206 RP004497225 UUGC0058
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025455 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39961
Antibody Information
	polyclonal (Nguyen et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CycT anon-74EFc (FlyBase, 1996-)
Additional comments
Other Comments
	Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells. (Nybakken et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells. In both Kc167 and S2R+ cells, cell morphology is aberrant and there is an increased frequency of microtubule-based mitotic spindles, indicative of a failure in mitosis. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) CycT encodes the large subunit of P-TEFb (positive transcription elongation factor b). (Peng et al., 1998) Identification: 6.0kb transcript identified during molecular analysis of the Eip74EF genomic region. (Burtis et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079403 NM_206395 NM_001275063 NM_001275064 RefSeq (Proteins) • NP_524127 NP_996117 NP_001261992 NP_001261993 DDBJ / EMBL / GenBank • AAC73052 AAF49325 AAF49325.1 AAS64974 AAS64974.1 AF051933 AGB94685 AGB94686 AI517680 AW941101 AY075353 CZ469497 CZ470491 CZ470819 CZ470981 CZ470982 Entrez Gene - A searchable database of RefSeq genes. • 39961 UniProtKB/Swiss-Prot • O96433
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cyclin, N-terminal (IPR006671) Cyclin-like (IPR013763) Cyclin C/H/T/L (IPR015429) Cyclin T (IPR015430) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • AT03646 GH28728
Linkouts
	BioGRID - A database of protein and genetic interactions • 65249 DroID - A comprehensive database of gene and protein interactions. • FBgn0025455 DRSC - Results from RNAi screens. • FBgn0025455 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025455 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6292-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025455 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39961 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39961 modMine - Data generated by the modENCODE project. • FBgn0025455 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O96433
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	anon-74EFc   CG6292 (Nybakken et al., 2005, Ardehali et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2008, Maia et al., 2007, Ni et al., 2010.12.1, Ni et al., 2011.7.19) CycT (Nybakken et al., 2005, Hanyu-Nakamura et al., 2008, Ivaldi et al., 2007, Guo et al., 2011, Srinivasan et al., 2008, Ardehali et al., 2009, Smith et al., 2011, Bakal et al., 2008, Maia et al., 2007, Zobeck et al., 2010, Tokusumi et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Zraly and Dingwall, 2012) Dmcyclin T (Peng et al., 1998) dT (Fu et al., 1999) ORE-14 (Maia et al., 2007) p124 (Yamaguchi et al., 1998) P-TEFb (Sims et al., 2004, Garriga and Grana, 2004, Saunders et al., 2005, Peng et al., 1998, Yamaguchi et al., 1998, Marshall et al., 1996, Marshall and Price, 1995, Zobeck et al., 2010, Hanyu-Nakamura et al., 2008, Boehm et al., 2003, Srinivasan et al., 2008, Zobeck et al., 2010) unnamed (Burtis et al., 1990)
Name Synonym	CyclinT (Ni et al., 2004) cyclin T (Peng, 1998.3.2, Schwartz et al., 2003) Cyclin T (Peng et al., 1998, Nguyen et al., 2012, Zhang et al., 2008) cyclin T1 (Zorio and Bentley, 2001) cyclin T2 (Zorio and Bentley, 2001) dCyclin T (Bartkowiak et al., 2010)
Secondary FlyBase IDs
	FBgn0023101
References ( 66 )
Generate a list of	All references relating to this gene ( 66 )
List References by type	Research paper  ( 33 ) Supplementary material  ( 8 ) Review  ( 4 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 7 )
	Baradaran-Heravi et al., 2012, Hum. Mol. Genet. 21(11): 2572--2587 Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. [FBrf0218299] Nguyen et al., 2012, Nucleic Acids Res. 40(12): 5283--5297 The Drosophila 7SK snRNP and the essential role of dHEXIM in development. [FBrf0218831] Tokusumi et al., 2012, PLoS ONE 7(7): e41604 Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204] Xu et al., 2012, Cell Host Microbe 12(4): 531--543 Transcriptional pausing controls a rapid antiviral innate immune response in Drosophila. [FBrf0219695] Zraly and Dingwall, 2012, Nucleic Acids Res. 40(13): 5975--5987 The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit. [FBrf0218975] Guo et al., 2011, Mol. Cell. Biol. 31(4): 639--651 Poly(A) Signals Located near the 5' End of Genes Are Silenced by a General Mechanism That Prevents Premature 3'-End Processing. [FBrf0212905] Smith et al., 2011, Mol. Cell 44(6): 954--965 The little elongation complex regulates small nuclear RNA transcription. [FBrf0217100] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...