• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Bub3

General Information
Symbol	Dmel\Bub3	Species	D. melanogaster
Name	Bub3	Annotation symbol	CG7581
Feature type	protein_coding_gene	FlyBase ID	FBgn0025457
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	99B7-99B7	Sequence location	3R:25,499,855..25,501,141 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Bub3 is referred to in FlyBase by the symbol Dmel\Bub3 (CG7581, FBgn0025457). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: mitotic cell cycle spindle assembly checkpoint; mitotic spindle organization. 5 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: G-protein beta WD-40 repeat; WD40 repeat; WD40 repeat 2; WD40 repeat, conserved site; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1637317_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Bub3. Gene sequence location is 3R:25499855..25501141.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN46662 HFA14168 BKN27317
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99B7-99B7   Limits computationally determined from genome sequence between P{PZ}l(3)0674306743 and P{PZ}ncd05884
Experimentally Determined Cytological Location
Cytogenetic map Notes References 22F-23A     (Delgrossi, 1998.11.13) 99B2-99B4     (Basu, 1998.8.28) 99B3-99B5   (determined by in situ hybridisation)   (Andre, 1999.4.14) 99B2-99B4   Map position is based on hybridisation of a Bub3 cDNA clone to P1 clones DS04127 and DS07294.   (Basu et al., 1998)
Experimentally Determined Recombination Data
Location	3- (Horn et al., 2003)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Bub3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Bub3-RA FBtr0085465  NM_058033   1234   326
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Bub3-PA   FBpp0084831   37.4   326   6.51     NP_477381   AAF56914
Additional Polypeptide Data & Comments
Reported size (kDa)	327 (aa); 37 (kD observed); 37 (kD predicted) (Basu et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) WD40-repeat-containing domain (IPR017986) G-protein beta WD-40 repeat (IPR020472) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201105   AA264034   AA539150   AA694880   AA817578   AE014297 AAF56914   AC007892   AF075594 AAD13398   AF088846 AAD44035   AF106679 AAD21971   AW942679   AY118526 AAM49895   BG638132   BG640999   BI367023   BI375640   BI485716   BI486892   BI579671   BP558247   BP558248   BT083437   BT120380   CO182507   CO185081   CO262985   CO267607   CO267989   CO284777   CO295359   CO307989   EC054285   EC197114   EC199236   EC236161   EC249512   GH740101   GH742951   GH743552   GH745262   GH749225   GH749623   GH749845   GH751094   GH752311   GH752926   GH753733   GH755792   GH755984   GH760178   GH761194   GH763088   GH765862   GH766034   GH775080   GH777529   GH777858   GH778256   GH780937   GH783943   GH786092   GH790910   GH791053   GH794809   GH796393   GH796854   GH803601   GH804241   GH808840   GH823353   GH826993   GH827487   GH831467   GH832552   GH840749   GH842543   GH846345   GH847242   GH849448   GH851354   GH851740   GH853268   GH856651   GH862303   GH862744   GH865992   GH866478   GH867306   GH868563   GH871785   GH874769   GH877502   GH877842   GH879949   GH881457   GH883951   GH887944   GH890612   GH895419   GH895800   GH899995   GH900563   GH904924   GH908226   GH911518   GH912085   GH915992   GH921632   GH924981   GH926203   GH933130   GH935895   GO254506   GO254528
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O76523 Q8MSW6 Q9VAJ2 Q9XYF7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference larval stage   neuroblast   (Basu et al., 1998) adult stage | male   spermatocyte   (Basu et al., 1998) epitope tag Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 5   cell   • kinetochore (Schittenhelm et al., 2007) Comment:Localization observed prometaphase until late anaphase of embryonic cycle 14
Additional Descriptive Data
	Bub3 protein shows a dynamic, cell cycle-dependent distribution pattern. During mitosis in cycling larval neuroblasts, interphase cells show a diffuse, nucleoplasmic staining. Bub3 protein becomes clearly localized to the kinetochore regions of the condensed chromosomes during prophase and prometaphase. As the chromosomes move to the metaphase plate, the intensity of Bub3 staining diminishes significantly. Weak kinetochore staining can be seen in early anaphase but disappears late in anaphase and telophase. During meiosis in spermatocytes Bub3 protein localizes to the kinetochores in prometaphase. It is also seen at the kinetochore region of spermatocytes during prophase/prometaphse of the second meiotic division. During metaphase, kinetochore staining becomes undetectable and no specific staining is observed in anaphase or telophase. In both mitosis and meiosis, Bub3 binds to the kinetochore during prophase/prometaphase. When individual chromosomes have reached a stable bipolar orientation at the metaphase plate, Bub3 protein begins to dissociate from the kinetochore. (Schittenhelm et al., 2007, Basu et al., 1998)
Marker for
Subcellular Localization
CV Term	kinetochore (Basu et al., 1998)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0025457    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0025457 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0025457 expression level Developmental Stage   Expression Level embryo 00-02hr    10040 embryo 02-04hr    18093 embryo 04-06hr    23558 embryo 06-08hr    15209 embryo 08-10hr    12130 embryo 10-12hr    6492 embryo 12-14hr    4689 embryo 14-16hr    4403 embryo 16-18hr    3419 embryo 18-20hr    1959 embryo 20-22hr    4379 embryo 22-24hr    3784 larva L1    1711 larva L2    1715 larva L3 12hr old    1454 larva L3 puffstage 1-2    2726 larva L3 puffstage 3-6    3101 larva L3 puffstage 7-9    3868 white prepupae new    3419 white prepupae 12hr    4075 white prepupae 24hr    4280 pupae 2d postWPP    1995 pupae 3d postWPP    1075 pupae 4d postWPP    895 adult male 01day    725 adult male 05day    912 adult male 30day    830 adult female 01day    3079 adult female 05day    5058 adult female 30day    5104 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10040) embryo 02-04hr  (18093) embryo 04-06hr  (23558) embryo 06-08hr  (15209) embryo 08-10hr  (12130) embryo 10-12hr  (6492) embryo 12-14hr  (4689) embryo 14-16hr  (4403) embryo 16-18hr  (3419) embryo 18-20hr  (1959) embryo 20-22hr  (4379) embryo 22-24hr  (3784) larva L1  (1711) larva L2  (1715) larva L3 12hr old  (1454) larva L3 puffstage 1-2  (2726) larva L3 puffstage 3-6  (3101) larva L3 puffstage 7-9  (3868) white prepupae new  (3419) white prepupae 12hr  (4075) white prepupae 24hr  (4280) pupae 2d postWPP  (1995) pupae 3d postWPP  (1075) pupae 4d postWPP  (895) adult male 01day  (725) adult male 05day  (912) adult male 30day  (830) adult female 01day  (3079) adult female 05day  (5058) adult female 30day  (5104) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10040) embryo 02-04hr  (18093) embryo 04-06hr  (23558) embryo 06-08hr  (15209) embryo 08-10hr  (12130) embryo 10-12hr  (6492) embryo 12-14hr  (4689) embryo 14-16hr  (4403) embryo 16-18hr  (3419) embryo 18-20hr  (1959) embryo 20-22hr  (4379) embryo 22-24hr  (3784) larva L1  (1711) larva L2  (1715) larva L3 12hr old  1454 larva L3 puffstage 1-2  (2726) larva L3 puffstage 3-6  (3101) larva L3 puffstage 7-9  (3868) white prepupae new  (3419) white prepupae 12hr  (4075) white prepupae 24hr  (4280) pupae 2d postWPP  (1995) pupae 3d postWPP    1075 pupae 4d postWPP    895 adult male 01day    725 adult male 05day    912 adult male 30day    830 adult female 01day  (3079) adult female 05day  (5058) adult female 30day  (5104) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10040 embryo 02-04hr  (18093) embryo 04-06hr  (23558) embryo 06-08hr  (15209) embryo 08-10hr  (12130) embryo 10-12hr    6492 embryo 12-14hr    4689 embryo 14-16hr    4403 embryo 16-18hr    3419 embryo 18-20hr    1959 embryo 20-22hr    4379 embryo 22-24hr    3784 larva L1    1711 larva L2    1715 larva L3 12hr old    1454 larva L3 puffstage 1-2    2726 larva L3 puffstage 3-6    3101 larva L3 puffstage 7-9    3868 white prepupae new    3419 white prepupae 12hr    4075 white prepupae 24hr    4280 pupae 2d postWPP    1995 pupae 3d postWPP    1075 pupae 4d postWPP    895 adult male 01day    725 adult male 05day    912 adult male 30day    830 adult female 01day    3079 adult female 05day    5058 adult female 30day    5104 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10040 embryo 02-04hr    18093 embryo 04-06hr    23558 embryo 06-08hr    15209 embryo 08-10hr    12130 embryo 10-12hr    6492 embryo 12-14hr    4689 embryo 14-16hr    4403 embryo 16-18hr    3419 embryo 18-20hr    1959 embryo 20-22hr    4379 embryo 22-24hr    3784 larva L1    1711 larva L2    1715 larva L3 12hr old    1454 larva L3 puffstage 1-2    2726 larva L3 puffstage 3-6    3101 larva L3 puffstage 7-9    3868 white prepupae new    3419 white prepupae 12hr    4075 white prepupae 24hr    4280 pupae 2d postWPP    1995 pupae 3d postWPP    1075 pupae 4d postWPP    895 adult male 01day    725 adult male 05day    912 adult male 30day    830 adult female 01day    3079 adult female 05day    5058 adult female 30day    5104 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0025457 expression level Developmental Stage   Expression Level embryo 00-02hr    10040 embryo 02-04hr    18093 embryo 04-06hr    23558 embryo 06-08hr    15209 embryo 08-10hr    12130 embryo 10-12hr    6492 embryo 12-14hr    4689 embryo 14-16hr    4403 embryo 16-18hr    3419 embryo 18-20hr    1959 embryo 20-22hr    4379 embryo 22-24hr    3784 larva L1    1711 larva L2    1715 larva L3 12hr old    1454 larva L3 puffstage 1-2    2726 larva L3 puffstage 3-6    3101 larva L3 puffstage 7-9    3868 white prepupae new    3419 white prepupae 12hr    4075 white prepupae 24hr    4280 pupae 2d postWPP    1995 pupae 3d postWPP    1075 pupae 4d postWPP    895 adult male 01day    725 adult male 05day    912 adult male 30day    830 adult female 01day    3079 adult female 05day    5058 adult female 30day    5104 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10040) embryo 02-04hr  (18093) embryo 04-06hr  (23558) embryo 06-08hr  (15209) embryo 08-10hr  (12130) embryo 10-12hr  (6492) embryo 12-14hr  (4689) embryo 14-16hr  (4403) embryo 16-18hr  (3419) embryo 18-20hr  (1959) embryo 20-22hr  (4379) embryo 22-24hr  (3784) larva L1  (1711) larva L2  (1715) larva L3 12hr old  (1454) larva L3 puffstage 1-2  (2726) larva L3 puffstage 3-6  (3101) larva L3 puffstage 7-9  (3868) white prepupae new  (3419) white prepupae 12hr  (4075) white prepupae 24hr  (4280) pupae 2d postWPP  (1995) pupae 3d postWPP  (1075) pupae 4d postWPP  (895) adult male 01day  (725) adult male 05day  (912) adult male 30day  (830) adult female 01day  (3079) adult female 05day  (5058) adult female 30day  (5104) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10040) embryo 02-04hr  (18093) embryo 04-06hr  (23558) embryo 06-08hr  (15209) embryo 08-10hr  (12130) embryo 10-12hr  (6492) embryo 12-14hr  (4689) embryo 14-16hr  (4403) embryo 16-18hr  (3419) embryo 18-20hr  1959 embryo 20-22hr  (4379) embryo 22-24hr  (3784) larva L1  1711 larva L2  1715 larva L3 12hr old  1454 larva L3 puffstage 1-2  (2726) larva L3 puffstage 3-6  (3101) larva L3 puffstage 7-9  (3868) white prepupae new  (3419) white prepupae 12hr  (4075) white prepupae 24hr  (4280) pupae 2d postWPP  1995 pupae 3d postWPP    1075 pupae 4d postWPP    895 adult male 01day    725 adult male 05day    912 adult male 30day    830 adult female 01day  (3079) adult female 05day  (5058) adult female 30day  (5104) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10040 embryo 02-04hr  18093 embryo 04-06hr  (23558) embryo 06-08hr  15209 embryo 08-10hr  12130 embryo 10-12hr    6492 embryo 12-14hr    4689 embryo 14-16hr    4403 embryo 16-18hr    3419 embryo 18-20hr    1959 embryo 20-22hr    4379 embryo 22-24hr    3784 larva L1    1711 larva L2    1715 larva L3 12hr old    1454 larva L3 puffstage 1-2    2726 larva L3 puffstage 3-6    3101 larva L3 puffstage 7-9    3868 white prepupae new    3419 white prepupae 12hr    4075 white prepupae 24hr    4280 pupae 2d postWPP    1995 pupae 3d postWPP    1075 pupae 4d postWPP    895 adult male 01day    725 adult male 05day    912 adult male 30day    830 adult female 01day    3079 adult female 05day    5058 adult female 30day    5104 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10040 embryo 02-04hr    18093 embryo 04-06hr    23558 embryo 06-08hr    15209 embryo 08-10hr    12130 embryo 10-12hr    6492 embryo 12-14hr    4689 embryo 14-16hr    4403 embryo 16-18hr    3419 embryo 18-20hr    1959 embryo 20-22hr    4379 embryo 22-24hr    3784 larva L1    1711 larva L2    1715 larva L3 12hr old    1454 larva L3 puffstage 1-2    2726 larva L3 puffstage 3-6    3101 larva L3 puffstage 7-9    3868 white prepupae new    3419 white prepupae 12hr    4075 white prepupae 24hr    4280 pupae 2d postWPP    1995 pupae 3d postWPP    1075 pupae 4d postWPP    895 adult male 01day    725 adult male 05day    912 adult male 30day    830 adult female 01day    3079 adult female 05day    5058 adult female 30day    5104 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0025457    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0025457 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0025457 expression level Tissue   Expression Level Larval Central Nervous System    986.575 Larval Midgut    148.9 Larval Hindgut    192.5 Larval Malpighian Tubules    171.8 Larval Fat Body    204.5 Larval Salivary Gland    399.4 Larval Trachea    445.625 Larval Carcass    252.625 Adult Head    129.6 Adult Eye    86.5 Adult Brain    218.1 Adult Thoracic-Abdominal Ganglion    133.1 Adult Crop    118.5 Adult Midgut    143.4 Adult Hindgut    116.4 Adult Malpighian Tubules    128.8 Adult Fat Body    107.1 Adult Salivary Gland    145.1 Adult Heart    100.175 Adult VirginFemale Spermatheca    89.8 Adult InseminatedFemale Spermatheca    101.5 Adult Ovary    689.4 Adult Testis    138.2 Adult Male Accessory Gland    138.6 Adult Carcass    95.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (986.575) Larval Midgut    148.9 Larval Hindgut    192.5 Larval Malpighian Tubules    171.8 Larval Fat Body    204.5 Larval Salivary Gland    399.4 Larval Trachea    445.625 Larval Carcass    252.625 Adult Head    129.6 Adult Eye    86.5 Adult Brain    218.1 Adult Thoracic-Abdominal Ganglion    133.1 Adult Crop    118.5 Adult Midgut    143.4 Adult Hindgut    116.4 Adult Malpighian Tubules    128.8 Adult Fat Body    107.1 Adult Salivary Gland    145.1 Adult Heart    100.175 Adult VirginFemale Spermatheca    89.8 Adult InseminatedFemale Spermatheca    101.5 Adult Ovary  (689.4) Adult Testis    138.2 Adult Male Accessory Gland    138.6 Adult Carcass    95.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    986.575 Larval Midgut    148.9 Larval Hindgut    192.5 Larval Malpighian Tubules    171.8 Larval Fat Body    204.5 Larval Salivary Gland    399.4 Larval Trachea    445.625 Larval Carcass    252.625 Adult Head    129.6 Adult Eye    86.5 Adult Brain    218.1 Adult Thoracic-Abdominal Ganglion    133.1 Adult Crop    118.5 Adult Midgut    143.4 Adult Hindgut    116.4 Adult Malpighian Tubules    128.8 Adult Fat Body    107.1 Adult Salivary Gland    145.1 Adult Heart    100.175 Adult VirginFemale Spermatheca    89.8 Adult InseminatedFemale Spermatheca    101.5 Adult Ovary    689.4 Adult Testis    138.2 Adult Male Accessory Gland    138.6 Adult Carcass    95.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    986.575 Larval Midgut    148.9 Larval Hindgut    192.5 Larval Malpighian Tubules    171.8 Larval Fat Body    204.5 Larval Salivary Gland    399.4 Larval Trachea    445.625 Larval Carcass    252.625 Adult Head    129.6 Adult Eye    86.5 Adult Brain    218.1 Adult Thoracic-Abdominal Ganglion    133.1 Adult Crop    118.5 Adult Midgut    143.4 Adult Hindgut    116.4 Adult Malpighian Tubules    128.8 Adult Fat Body    107.1 Adult Salivary Gland    145.1 Adult Heart    100.175 Adult VirginFemale Spermatheca    89.8 Adult InseminatedFemale Spermatheca    101.5 Adult Ovary    689.4 Adult Testis    138.2 Adult Male Accessory Gland    138.6 Adult Carcass    95.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0025457 expression level Tissue   Expression Level Larval Central Nervous System    986.575 Larval Midgut    148.9 Larval Hindgut    192.5 Larval Malpighian Tubules    171.8 Larval Fat Body    204.5 Larval Salivary Gland    399.4 Larval Trachea    445.625 Larval Carcass    252.625 Adult Head    129.6 Adult Eye    86.5 Adult Brain    218.1 Adult Thoracic-Abdominal Ganglion    133.1 Adult Crop    118.5 Adult Midgut    143.4 Adult Hindgut    116.4 Adult Malpighian Tubules    128.8 Adult Fat Body    107.1 Adult Salivary Gland    145.1 Adult Heart    100.175 Adult VirginFemale Spermatheca    89.8 Adult InseminatedFemale Spermatheca    101.5 Adult Ovary    689.4 Adult Testis    138.2 Adult Male Accessory Gland    138.6 Adult Carcass    95.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (986.575) Larval Midgut    148.9 Larval Hindgut    192.5 Larval Malpighian Tubules    171.8 Larval Fat Body    204.5 Larval Salivary Gland    399.4 Larval Trachea    445.625 Larval Carcass    252.625 Adult Head    129.6 Adult Eye    86.5 Adult Brain    218.1 Adult Thoracic-Abdominal Ganglion    133.1 Adult Crop    118.5 Adult Midgut    143.4 Adult Hindgut    116.4 Adult Malpighian Tubules    128.8 Adult Fat Body    107.1 Adult Salivary Gland    145.1 Adult Heart    100.175 Adult VirginFemale Spermatheca    89.8 Adult InseminatedFemale Spermatheca    101.5 Adult Ovary  689.4 Adult Testis    138.2 Adult Male Accessory Gland    138.6 Adult Carcass    95.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    986.575 Larval Midgut    148.9 Larval Hindgut    192.5 Larval Malpighian Tubules    171.8 Larval Fat Body    204.5 Larval Salivary Gland    399.4 Larval Trachea    445.625 Larval Carcass    252.625 Adult Head    129.6 Adult Eye    86.5 Adult Brain    218.1 Adult Thoracic-Abdominal Ganglion    133.1 Adult Crop    118.5 Adult Midgut    143.4 Adult Hindgut    116.4 Adult Malpighian Tubules    128.8 Adult Fat Body    107.1 Adult Salivary Gland    145.1 Adult Heart    100.175 Adult VirginFemale Spermatheca    89.8 Adult InseminatedFemale Spermatheca    101.5 Adult Ovary    689.4 Adult Testis    138.2 Adult Male Accessory Gland    138.6 Adult Carcass    95.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    986.575 Larval Midgut    148.9 Larval Hindgut    192.5 Larval Malpighian Tubules    171.8 Larval Fat Body    204.5 Larval Salivary Gland    399.4 Larval Trachea    445.625 Larval Carcass    252.625 Adult Head    129.6 Adult Eye    86.5 Adult Brain    218.1 Adult Thoracic-Abdominal Ganglion    133.1 Adult Crop    118.5 Adult Midgut    143.4 Adult Hindgut    116.4 Adult Malpighian Tubules    128.8 Adult Fat Body    107.1 Adult Salivary Gland    145.1 Adult Heart    100.175 Adult VirginFemale Spermatheca    89.8 Adult InseminatedFemale Spermatheca    101.5 Adult Ovary    689.4 Adult Testis    138.2 Adult Male Accessory Gland    138.6 Adult Carcass    95.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    129.6   NA  Eye    86.5   NA  Brain    218.1   986.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    133.1   NA  Crop    118.5   148.9  Midgut    143.4   192.5  Hindgut    116.4   171.8  Malpighian Tubules    128.8   204.5  Fat Body    107.1   399.4  Salivary Gland    145.1   NA  Heart    100.175   445.625  Trachea    NA   NA  VirginFemale Spermatheca    89.8   NA  InseminatedFemale Spermatheca    101.5   NA  Ovary    689.4   NA  Testis    138.2   NA  Male Accessory Gland    138.6   252.625  Carcass    95.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025457 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7581-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Bub3 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Bub3GD9924 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Bub3GD9924 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 Bub3GD9924
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Bub3 Class Mutagen Stocks Known lesion Bub31 0 -- Bub3233 piggyBac transposase 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Bub3 Class Mutagen Stocks Known lesion Bub3GD9924 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Bub3HMS00789 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Bub3T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9924} NA P{TRiP.HMS00789} NA characterization construct P{gEGFP-Bub3} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{3xP3-EYFP,p-tTA-K10}Bub3233 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mitotic cell cycle spindle assembly checkpoint inferred from direct assay (Logarinho et al., 2004) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007)
Cellular Component
CV term Evidence References
kinetochore inferred from direct assay (Basu et al., 1998, Schittenhelm et al., 2007) microtubule associated complex inferred from direct assay (Hughes et al., 2008) nucleoplasm inferred from direct assay (Basu et al., 1998)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mitotic cell cycle checkpoint non-traceable author statement (Basu, 1998.6.30)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Bub3 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68354 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025457 DroID - A comprehensive database of gene and protein interactions. • FBgn0025457 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43490
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22876 Dgri\GH18686 Dmoj\GI24196 Dper\GL13583 Dpse\GA20454 Dsec\GM12232 Dsim\GD17697 Dvir\GJ10544 Dwil\GK11174 Dyak\GE10441
Curated drosophilid orthologs	Dpse\GA20454
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007469-PA Aedes aegypti (mosquito) AGAP010544-PA Anopheles gambiae (mosquito) XP_393536.2 Apis mellifera (honey bee) XP_001947199.1 Acyrthosiphon pisum (pea aphid) At3g19590.1 Arabidopsis thaliana (wall cress) 84472 Batrachochytrium dendrobatidis (chytrid fungus) 115171 Branchiostoma floridae (lancelet) 125481 Branchiostoma floridae (lancelet) XP_001895477.1 Brugia malayi (roundworm nematode) BGIBMGA004646-PA Bombyx mori (silk worm) ENSBTAP00000023811 Bos taurus (bovine) CBP19977 Caenorhabditis briggsae (nematode) CE19233 Caenorhabditis elegans (worm) ENSCAFP00000008940 Canis familiaris (dog) ENSCINP00000019572 Ciona intestinalis (sea squirt) JA17144 Caenorhabditis japonica (nematode) CPIJ016504 Culex pipens (mosquito) ENSCPOP00000010757 Cavia porcellus (guinea pig) 106140 Chlamidomonas reinhardtii (green alga) RP07713 Caenorhabditis remanei (nematode) ENSCSAVP00000001136 Ciona savignyi (sedentary tunicate) 21337 Capitella spl (polychaete worm) DDB0233126 Dictyostelium discoideum (amoeba) 310020 Daphnia pulex (daphnia) ENSECAP00000007934 Equus caballus (horse) ENSGACP00000003304 Gymnopilus aculeatus (mushroom) ENSGALP00000015742 Gallus gallus (chicken) GL50803_102890 Giardia lamblia (flagellated protozoan) 156412 Hypsipyla robusta (cedar shoot borer) ENSP00000357858 Homo sapiens (human) ISCW000999-PA Ixodes scapularis (deer tick) 223691 Lottia gigantea (owl limpet) 24711 Monocosta brevicollis (choanoflagellate) ENSMODP00000009357 Monodelphis domestica (gray opossum) ENSMMUP00000004124 Macaca mulatta (rhesus monkey) ENSMUSP00000081547 Mus musculus (house mouse) 226653 Nematostella vectensis (starlet anemone) XP_001607033.1 Nasonia vitripennis (wasp) ENSOANP00000019270 Ornithorynchus anatinus (platypus) ENSORLP00000011991 Oryzias latipes (japanese killifish) LOC_Os03g33580.1 Oryza sativa (asian rice) PHUM002114-PA Pediculus humanus (human body louse) PP19777 Pristionchus pacificus (nematode) 106330 Physcomitrella patens (moss) ENSPPYP00000003192 Pongo pygmaeus (orangutan) 44460 Phytophthora ramorum (sudden oak death pathogen) 132132 Phytophthora sojae (root rot pathogen) 202067 Populus trichocarpa (black cottonwood) ENSPTRP00000005339 Pan troglodytes (chimpanzee) 4896454 Sorghum bicolor (sorghum) Smp_045060 Schistosoma mansoni (trematode parasite) SPAC23H3.08c Schizosaccharomyces pombe (fission yeast) XP_780636.1 Strongylocentrotus purpuratus (purple sea urchin) 53336 Trichoplax adhaerens (metazoa) TA14430 Theileria annulata (apicomplexan parasite) XP_970295.1 Tribolium castaneum (red flour beetle) ENSTNIP00000022616 Tetraodon nigroviridis (green spotted pufferfish) TP02_0663 Theileria parva (parasitic protozoan) 3058 Thalassiosira pseudonana (marine diatom) ENSTRUP00000026550 Takifugu rubripes (pufferfish Takifugu) 117367.m00003 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000021098 Xenopus tropicalis (frog) YALI0F19558g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11344 NV10243 LH11994 ISCW000999 FBgn0228302 FBgn0213185 FBgn0197824 FBgn0189246 FBgn0167169 JGI_V11_310020 FBgn0080449 FBgn0151188 FBgn0146919 FBgn0126153 FBgn0099870 CPIJ016504 BGIBMGA004646 ACYPI009048 GB15882 AGAP010544 AAEL007469 PHUM515720 GLEAN_11049
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	32989 y1 sc* v1; P{TRiP.HMS00789}attP2
VDRC	v21037 w1118; P{GD9924}v21037
Genomic Clones ( 2 )
	BACR02O03 BACR10L12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 106 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23540
Other clones	FI07632 RT06163
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM01720 LD03679 LD07449 LD17161 LD17239 RE52688 RE63501 RE69051 RE70373 RE73738 SD12204
Other clones	38690 79778 152905 CK01.118C.G6 EC22890 EC29290 EC054285 EK087004 EK089859 EK151056 EK166802 EK209534 EK256342 FGM313H06 RP01508 RP01578 RP001007365 RP001009555 RP001016827 RP001022421 RP001025418 RP001048270 RP001056717 RP003013131 RP003017702 RP003027613 RP003037458 RP003042556 RP003066621 RP003067271 RP003081318 RP003086217 RP003095587 RP003110316 RP003142464 RP003147430 RP003147645 RP003151890 RP003155743 RP003165056 RP003173042 RP003177622 RP003185469 RP003187770 RP003208503 RP003212364 RP003215238 RP003224273 RP003226885 RP003228122 RP003229266 RP003235271 RP003235356 RP003243118 RP003246637 RP003268763 RP003286506 RP003288685 RP003312734 RP003315176 RP003315509 RP003315946 RP003341941 RP003355559 RP003357410 RP003365255 RP003373867 RP003375383 RP003385421 RP003385479 RP003392971 RP003410186 RP003411773 RP003437608 RP003485751 RP003487871 RP003489619 RP003516369 RP003539197 RP003540153 RP003540790 RP003556126 RP003566020 RP003572844 RP003574536 RP003580809 RP003626342 RP003634748 RP003642431 RP003654092 RP003664208 RP003679011
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025457 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43490
Antibody Information
	polyclonal (Basu et al., 1998)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	FlyBase curator comment: the insertion in the "f03381" Exelixis line (PBac{WH}CAP-D2f03381) was originally assigned to the Bub3 gene in FBrf0179797, resulting in the "Bub3f03381" (FBal0162743) allele. However, FBrf0184340 shows that the insertion is actually within CAP-D2. (Bloomington Drosophila Stock Center, 2004.11.6)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058033 RefSeq (Proteins) • NP_477381 DDBJ / EMBL / GenBank • AA201105 AA817578 AAD13398 AAD21971 AAD44035 AAF56914 AAM49895 AC007892 AF075594 AF088846 AF106679 AW942679 AY118526 Entrez Gene - A searchable database of RefSeq genes. • 43490 UniProtKB/TrEMBL • O76523 Q8MSW6 Q9VAJ2 Q9XYF7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) WD40-repeat-containing domain (IPR017986) G-protein beta WD-40 repeat (IPR020472) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68354 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025457 DroID - A comprehensive database of gene and protein interactions. • FBgn0025457 DRSC - Results from RNAi screens. • FBgn0025457 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025457 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7581-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025457 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43490 InParanoid A subset of ortholog calls from InParanoid. • AAEL007469-PA Aedes aegypti (mosquito) AGAP010544-PA Anopheles gambiae (mosquito) XP_393536.2 Apis mellifera (honey bee) XP_001947199.1 Acyrthosiphon pisum (pea aphid) At3g19590.1 Arabidopsis thaliana (wall cress) 84472 Batrachochytrium dendrobatidis (chytrid fungus) 115171 Branchiostoma floridae (lancelet) 125481 Branchiostoma floridae (lancelet) XP_001895477.1 Brugia malayi (roundworm nematode) BGIBMGA004646-PA Bombyx mori (silk worm) ENSBTAP00000023811 Bos taurus (bovine) CBP19977 Caenorhabditis briggsae (nematode) CE19233 Caenorhabditis elegans (worm) ENSCAFP00000008940 Canis familiaris (dog) ENSCINP00000019572 Ciona intestinalis (sea squirt) JA17144 Caenorhabditis japonica (nematode) CPIJ016504 Culex pipens (mosquito) ENSCPOP00000010757 Cavia porcellus (guinea pig) 106140 Chlamidomonas reinhardtii (green alga) RP07713 Caenorhabditis remanei (nematode) ENSCSAVP00000001136 Ciona savignyi (sedentary tunicate) 21337 Capitella spl (polychaete worm) DDB0233126 Dictyostelium discoideum (amoeba) 310020 Daphnia pulex (daphnia) ENSECAP00000007934 Equus caballus (horse) ENSGACP00000003304 Gymnopilus aculeatus (mushroom) ENSGALP00000015742 Gallus gallus (chicken) GL50803_102890 Giardia lamblia (flagellated protozoan) 156412 Hypsipyla robusta (cedar shoot borer) ENSP00000357858 Homo sapiens (human) ISCW000999-PA Ixodes scapularis (deer tick) 223691 Lottia gigantea (owl limpet) 24711 Monocosta brevicollis (choanoflagellate) ENSMODP00000009357 Monodelphis domestica (gray opossum) ENSMMUP00000004124 Macaca mulatta (rhesus monkey) ENSMUSP00000081547 Mus musculus (house mouse) 226653 Nematostella vectensis (starlet anemone) XP_001607033.1 Nasonia vitripennis (wasp) ENSOANP00000019270 Ornithorynchus anatinus (platypus) ENSORLP00000011991 Oryzias latipes (japanese killifish) LOC_Os03g33580.1 Oryza sativa (asian rice) PHUM002114-PA Pediculus humanus (human body louse) PP19777 Pristionchus pacificus (nematode) 106330 Physcomitrella patens (moss) ENSPPYP00000003192 Pongo pygmaeus (orangutan) 44460 Phytophthora ramorum (sudden oak death pathogen) 132132 Phytophthora sojae (root rot pathogen) 202067 Populus trichocarpa (black cottonwood) ENSPTRP00000005339 Pan troglodytes (chimpanzee) 4896454 Sorghum bicolor (sorghum) Smp_045060 Schistosoma mansoni (trematode parasite) SPAC23H3.08c Schizosaccharomyces pombe (fission yeast) XP_780636.1 Strongylocentrotus purpuratus (purple sea urchin) 53336 Trichoplax adhaerens (metazoa) TA14430 Theileria annulata (apicomplexan parasite) XP_970295.1 Tribolium castaneum (red flour beetle) ENSTNIP00000022616 Tetraodon nigroviridis (green spotted pufferfish) TP02_0663 Theileria parva (parasitic protozoan) 3058 Thalassiosira pseudonana (marine diatom) ENSTRUP00000026550 Takifugu rubripes (pufferfish Takifugu) 117367.m00003 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000021098 Xenopus tropicalis (frog) YALI0F19558g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/bub3-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43490 modMine - Data generated by the modENCODE project. • FBgn0025457 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11344 NV10243 LH11994 ISCW000999 FBgn0228302 FBgn0213185 FBgn0197824 FBgn0189246 FBgn0167169 JGI_V11_310020 FBgn0080449 FBgn0151188 FBgn0146919 FBgn0126153 FBgn0099870 CPIJ016504 BGIBMGA004646 ACYPI009048 GB15882 AGAP010544 AAEL007469 PHUM515720 GLEAN_11049
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	bub3 (Basu, 1998.6.30, Martins et al., 2007, Martins et al., 2008, Somma et al., 2008, Castellanos et al., 2008, Williams et al., 2007, Martins et al., 2009, Wainman et al., 2009) Bub3 (De Lucia et al., 2005, Schittenhelm et al., 2007, Goshima et al., 2007, Georlette et al., 2007, Lopes et al., 2005, Wen et al., 2008, Pandey et al., 2007, Peng et al., 2007, Martins et al., 2009, Chen et al., 2008, Przewloka et al., 2011) CG7581 (Goshima et al., 2007, Haussmann et al., 2008, Hughes et al., 2008, Chen et al., 2008, Ni et al., 2010.12.1) dBUB3 (Dobie et al., 1999) Dmbub3 (Lopes et al., 2000)
Name Synonym	Bub3   bub3 (Somma et al., 2008)
Secondary FlyBase IDs
References ( 47 )
Generate a list of	All references relating to this gene ( 47 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Przewloka et al., 2011, Curr. Biol. 21(5): 399--405 CENP-C Is a Structural Platform for Kinetochore Assembly. [FBrf0213151] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...