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Gene Dmel\bab2

General Information
Symbol	Dmel\bab2	Species	D. melanogaster
Name	bric a brac 2	Annotation symbol	CG9102
Feature type	protein_coding_gene	FlyBase ID	FBgn0025525
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	bab, bab-II, BTB-II
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	61F2-61F3	Sequence location	3L:1,140,429..1,177,276 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene bric a brac 2 is referred to in FlyBase by the symbol Dmel\bab2 (CG9102, FBgn0025525). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; AT DNA binding. There is experimental evidence that it is involved in the biological process: female gonad development; transcription, DNA-dependent; imaginal disc-derived leg morphogenesis. 22 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; organ system; thoracic segment; appendage segment; adult; vitellarium; embryonic/larval dorsal vessel; imaginal precursor; prothoracic leg; embryonic/larval imaginal precursor; terminal filament. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: BTB/POZ; BTB/POZ fold; BTB/POZ-like; DNA binding HTH domain, Psq-type; Homeodomain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult Malpighian tubules, adult heart, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval Malpighian tubules, adult fat body, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624060_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of bab2. Gene sequence location is 3L:1140429..1177276.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 61F2-61F3   Limits computationally determined from genome sequence between P{PZ}l(3)0596705967 and P{PZ}l(3)0264002640
Experimentally Determined Cytological Location
Cytogenetic map Notes References 61F1-61F2     (Laski, 1994.9.5) 61F-61F     (Pointud, 1998.9.23)
Experimentally Determined Recombination Data
Location	3- (Laski, 1994.9.5)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\bab2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) bab2-RA FBtr0072639  NM_079155   5149   1067 bab2-RB FBtr0333271  NM_001274313   5146   1066
Additional Transcript Data & Comments
Reported size (kB)	5.4 (northern blot) (Couderc et al., 2002)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein bab2-PA   FBpp0072535   114.7   1067   6.32     NP_523879   AAF47442 bab2-PB   FBpp0305469   114.6   1066   6.32     NP_001261242   AGB93937
Additional Polypeptide Data & Comments
Reported size (kDa)	1067 (aa); 145 (kD) (Couderc et al., 2002)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) DNA binding HTH domain, Psq-type (IPR007889) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Homeodomain-like (IPR009057)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141333   AA141456   AA141593   AA141676   AA141714   AA141885   AA142289   AE014296 AAF47442   AE014296 AGB93937   AI063430   AJ252173 CAB64388   BF489526   BG632096   BG637093   BI358319   BI367893   BI565761   BI566503   BI571671   BI571679   BI578471   BI578932   BI588633   BI589043   BI604852   BI614339   BI620666   BI638345   BI639929   BT009963 AAQ22432   BT023842   CO177549   CO178669   CO179410   CO179610   CO187754   CO188508   CO196531   CO262294   CO264929   CO265804   CO266018   CO266528   CO267012   CO268279   CO268775   CO268945   CO269723   CO269956   CO270891   CO271243   CO271944   CO272166   CO272320   CO273023   CO273402   CO273774   CO275886   CO278056   CO279733   CO280398   CO280883   CO280947   CO281268   CO281528   CO281817   CO281956   CO283032   CO284463   CO284589   CO284981   CO285421   CO286248   CO286446   CO291601   CO291625   CO292457   CO294536   CO294915   CO295160   CO295477   CO296503   CO299548   CO299908   CO300458   CO300848   CO302228   CO302593   CO302803   CO303448   CO304580   CO304688   CO304728   CO307952   CO308750   CO309979   CO311288   CO312884   CO314047   CO315692   CO316193   CO316223   CO316720   CO320331   CO321061   CO321607   CO322504   CO322659   CO325971   CO325983   CO326143   CO326309   CO326933   CO327053   CO328882   CO329578   CO331136   CO331743   CO331749   CO332242   CO332969   CO333465   CO336331   CO339030   CO339033   CO339323   CO339724   CO339761   CO340147   CO340901   CO341425   CO341811   CO342049   CO342388   CO343822   CO344057   CO344644   CZ484021   CZ485557   CZ489697   CZ489698   EC060934   EC061938   EC062222   EC067941   EC069258   EC077601   EC078028   EC090691   EC200410   EC205751   EC217577   EC222466   EC222733   EC233348   EC245660   EC246467   EC249030   GH752679   GH757706   GH780048   GH784742   GH800533   GH807917   GH814248   GH817840   GH827586   GH829830   GH838301   GH840506   GH848599   GH863354   GH864673   GH869080   GH871398   GH879794   GH893779   GH908583   GH915375   GH938631   U14399 AAA50834
UniProtKB/Swiss-Prot	Q9W0K4
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000161031 3L:1,175,524..1,175,549 bound_moiety=bab1-XP evidence=experimental (Bergman et al., 2005, Lours et al., 2003) protein binding site FBsf0000161032 3L:1,175,576..1,175,590 bound_moiety=bab1-XP evidence=experimental (Lours et al., 2003, Bergman et al., 2005) regulatory region FBsf0000435588 3L:1,169,506..1,173,256 evidence=Reporter construct (in vivo) (Williams et al., 2008, Halfon, 2012.6.19) regulatory region FBsf0000436021 3L:1,124,097..1,130,422 evidence=Reporter construct (in vivo) (Williams et al., 2008, Halfon, 2012.6.19) regulatory region FBsf0000436249 3L:1,163,390..1,169,498 evidence=Reporter construct (in vivo) (Williams et al., 2008, Halfon, 2012.6.19) regulatory region FBsf0000436478 3L:1,128,997..1,135,356 evidence=Reporter construct (in vivo) (Williams et al., 2008, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 7 -- 8   esophagus anlage   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) embryonic stage 9 -- 10   esophagus primordium   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   circular visceral muscle primordium   (Fisher et al., 2012) clypeo-labral primordium   (Fisher et al., 2012) epipharynx primordium   (Fisher et al., 2012) esophagus primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) hypopharynx proper primordium   (Fisher et al., 2012) longitudinal visceral muscle primordium   (Fisher et al., 2012) proventriculus primordium   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   circular visceral muscle fiber   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic esophagus   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) labral segment   (Fisher et al., 2012) longitudinal visceral muscle fiber   (Fisher et al., 2012) third instar larval stage   ventral thoracic disc | restricted   (Couderc et al., 2002) prepupal stage   ovary | restricted   (Couderc et al., 2002)
Additional Descriptive Data
	is bab2 transcript is highly expressed in cells that form the terminal filament of the ovary. Low levels of transcript expression are observed in the apical cells, 'swarm cells' and some interstitial non-germ cells of the ovary. Transcript is expressed in the primordium of tarsal segments TS1-TS4 in leg imaginal discs. (Couderc et al., 2002)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   ventral thoracic disc | restricted   (Couderc et al., 2002) wandering third instar larval stage   male genital disc | restricted   (Couderc et al., 2002) female genital disc | restricted   (Couderc et al., 2002) embryonic/larval central nervous system | restricted   (Couderc et al., 2002) prepupal stage   central nervous system | restricted   (Couderc et al., 2002) prepupal stage P1   ovary | restricted   (Couderc et al., 2002)
Additional Descriptive Data
	Protein is highly expressed in cells that form the terminal filament of the ovary. Lower levels of protein expression are observed in the apical cells, \'swarm cells\' and some interstitial non-germ cells of the ovary. Protein expression in the leg disc is graded with highest expression in TS3, TS4 and the proximal region of TS5 and lower expression in TS1 and TS2. Expression is also observed in the peripodial membrane and the periphery of the disc that gives rise to thorax structures.In the female genital disc strongest protein expression is observed in the vaginal plate primordium and the A8 tergite.In the male genital disc strongest protein expression is observed in a region of the male genital primordium.bab2-expressing cells are found in the central brain hemisphers and the thoracic ganglia. (Couderc et al., 2002)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Lours et al., 2003) polytene chromosome inferred from direct assay (Lours et al., 2003) NOT polytene chromosome chromocenter inferred from direct assay (Lours et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult Malpighian tubules, adult heart, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval Malpighian tubules, adult fat body, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    461.625 Larval Midgut    298.1 Larval Hindgut    274.4 Larval Malpighian Tubules    228.9 Larval Fat Body    87 Larval Salivary Gland    99.1 Larval Trachea    49.15 Larval Carcass    199.9 Adult Head    181.5 Adult Eye    243.225 Adult Brain    325.3 Adult Thoracic-Abdominal Ganglion    353 Adult Crop    1341.2 Adult Midgut    469.9 Adult Hindgut    649 Adult Malpighian Tubules    565.1 Adult Fat Body    310.4 Adult Salivary Gland    986.7 Adult Heart    501.625 Adult VirginFemale Spermatheca    77.3 Adult InseminatedFemale Spermatheca    98.4 Adult Ovary    6.2 Adult Testis    31.4 Adult Male Accessory Gland    27.6 Adult Carcass    295.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    461.625 Larval Midgut    298.1 Larval Hindgut    274.4 Larval Malpighian Tubules    228.9 Larval Fat Body    87 Larval Salivary Gland    99.1 Larval Trachea    49.15 Larval Carcass    199.9 Adult Head    181.5 Adult Eye    243.225 Adult Brain    325.3 Adult Thoracic-Abdominal Ganglion    353 Adult Crop  (1341.2) Adult Midgut    469.9 Adult Hindgut  (649) Adult Malpighian Tubules  (565.1) Adult Fat Body    310.4 Adult Salivary Gland  (986.7) Adult Heart  501.625 Adult VirginFemale Spermatheca    77.3 Adult InseminatedFemale Spermatheca    98.4 Adult Ovary    6.2 Adult Testis    31.4 Adult Male Accessory Gland    27.6 Adult Carcass    295.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    461.625 Larval Midgut    298.1 Larval Hindgut    274.4 Larval Malpighian Tubules    228.9 Larval Fat Body    87 Larval Salivary Gland    99.1 Larval Trachea    49.15 Larval Carcass    199.9 Adult Head    181.5 Adult Eye    243.225 Adult Brain    325.3 Adult Thoracic-Abdominal Ganglion    353 Adult Crop  (1341.2) Adult Midgut    469.9 Adult Hindgut    649 Adult Malpighian Tubules    565.1 Adult Fat Body    310.4 Adult Salivary Gland    986.7 Adult Heart    501.625 Adult VirginFemale Spermatheca    77.3 Adult InseminatedFemale Spermatheca    98.4 Adult Ovary    6.2 Adult Testis    31.4 Adult Male Accessory Gland    27.6 Adult Carcass    295.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    461.625 Larval Midgut    298.1 Larval Hindgut    274.4 Larval Malpighian Tubules    228.9 Larval Fat Body    87 Larval Salivary Gland    99.1 Larval Trachea    49.15 Larval Carcass    199.9 Adult Head    181.5 Adult Eye    243.225 Adult Brain    325.3 Adult Thoracic-Abdominal Ganglion    353 Adult Crop    1341.2 Adult Midgut    469.9 Adult Hindgut    649 Adult Malpighian Tubules    565.1 Adult Fat Body    310.4 Adult Salivary Gland    986.7 Adult Heart    501.625 Adult VirginFemale Spermatheca    77.3 Adult InseminatedFemale Spermatheca    98.4 Adult Ovary    6.2 Adult Testis    31.4 Adult Male Accessory Gland    27.6 Adult Carcass    295.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    461.625 Larval Midgut    298.1 Larval Hindgut    274.4 Larval Malpighian Tubules    228.9 Larval Fat Body    87 Larval Salivary Gland    99.1 Larval Trachea    49.15 Larval Carcass    199.9 Adult Head    181.5 Adult Eye    243.225 Adult Brain    325.3 Adult Thoracic-Abdominal Ganglion    353 Adult Crop    1341.2 Adult Midgut    469.9 Adult Hindgut    649 Adult Malpighian Tubules    565.1 Adult Fat Body    310.4 Adult Salivary Gland    986.7 Adult Heart    501.625 Adult VirginFemale Spermatheca    77.3 Adult InseminatedFemale Spermatheca    98.4 Adult Ovary    6.2 Adult Testis    31.4 Adult Male Accessory Gland    27.6 Adult Carcass    295.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    461.625 Larval Midgut    298.1 Larval Hindgut    274.4 Larval Malpighian Tubules    228.9 Larval Fat Body    87 Larval Salivary Gland    99.1 Larval Trachea    49.15 Larval Carcass    199.9 Adult Head    181.5 Adult Eye    243.225 Adult Brain    325.3 Adult Thoracic-Abdominal Ganglion    353 Adult Crop  (1341.2) Adult Midgut    469.9 Adult Hindgut  649 Adult Malpighian Tubules  565.1 Adult Fat Body    310.4 Adult Salivary Gland  (986.7) Adult Heart  501.625 Adult VirginFemale Spermatheca    77.3 Adult InseminatedFemale Spermatheca    98.4 Adult Ovary    6.2 Adult Testis    31.4 Adult Male Accessory Gland    27.6 Adult Carcass    295.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    461.625 Larval Midgut    298.1 Larval Hindgut    274.4 Larval Malpighian Tubules    228.9 Larval Fat Body    87 Larval Salivary Gland    99.1 Larval Trachea    49.15 Larval Carcass    199.9 Adult Head    181.5 Adult Eye    243.225 Adult Brain    325.3 Adult Thoracic-Abdominal Ganglion    353 Adult Crop  1341.2 Adult Midgut    469.9 Adult Hindgut    649 Adult Malpighian Tubules    565.1 Adult Fat Body    310.4 Adult Salivary Gland    986.7 Adult Heart    501.625 Adult VirginFemale Spermatheca    77.3 Adult InseminatedFemale Spermatheca    98.4 Adult Ovary    6.2 Adult Testis    31.4 Adult Male Accessory Gland    27.6 Adult Carcass    295.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    461.625 Larval Midgut    298.1 Larval Hindgut    274.4 Larval Malpighian Tubules    228.9 Larval Fat Body    87 Larval Salivary Gland    99.1 Larval Trachea    49.15 Larval Carcass    199.9 Adult Head    181.5 Adult Eye    243.225 Adult Brain    325.3 Adult Thoracic-Abdominal Ganglion    353 Adult Crop    1341.2 Adult Midgut    469.9 Adult Hindgut    649 Adult Malpighian Tubules    565.1 Adult Fat Body    310.4 Adult Salivary Gland    986.7 Adult Heart    501.625 Adult VirginFemale Spermatheca    77.3 Adult InseminatedFemale Spermatheca    98.4 Adult Ovary    6.2 Adult Testis    31.4 Adult Male Accessory Gland    27.6 Adult Carcass    295.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    181.5   NA  Eye    243.225   NA  Brain    325.3   461.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    353   NA  Crop    1341.2   298.1  Midgut    469.9   274.4  Hindgut    649   228.9  Malpighian Tubules    565.1   87  Fat Body    310.4   99.1  Salivary Gland    986.7   NA  Heart    501.625   49.15  Trachea    NA   NA  VirginFemale Spermatheca    77.3   NA  InseminatedFemale Spermatheca    98.4   NA  Ovary    6.2   NA  Testis    31.4   NA  Male Accessory Gland    27.6   199.9  Carcass    295.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    27 central nervous system, pupae P8    27 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    59 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3  (27) central nervous system, pupae P8  (27) head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae  (59) digestive system, larvae L3 wandering    6 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    27 central nervous system, pupae P8    27 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    59 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    27 central nervous system, pupae P8    27 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    59 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    27 central nervous system, pupae P8    27 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    59 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3  27 central nervous system, pupae P8  27 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae  (59) digestive system, larvae L3 wandering    6 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    27 central nervous system, pupae P8    27 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    59 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    27 central nervous system, pupae P8    27 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    59 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    7 carcass, larvae L3 wandering    22 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    14 embryo 06-08hr    40 embryo 08-10hr    48 embryo 10-12hr    39 embryo 12-14hr    41 embryo 14-16hr    24 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    9 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    18 white prepupae new    22 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    8 adult male 30day    6 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    14 embryo 06-08hr  (40) embryo 08-10hr  (48) embryo 10-12hr  (39) embryo 12-14hr  (41) embryo 14-16hr    24 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    9 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    18 white prepupae new    22 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    8 adult male 30day    6 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    14 embryo 06-08hr    40 embryo 08-10hr    48 embryo 10-12hr    39 embryo 12-14hr    41 embryo 14-16hr    24 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    9 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    18 white prepupae new    22 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    8 adult male 30day    6 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    14 embryo 06-08hr    40 embryo 08-10hr    48 embryo 10-12hr    39 embryo 12-14hr    41 embryo 14-16hr    24 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    9 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    18 white prepupae new    22 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    8 adult male 30day    6 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    14 embryo 06-08hr    40 embryo 08-10hr    48 embryo 10-12hr    39 embryo 12-14hr    41 embryo 14-16hr    24 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    9 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    18 white prepupae new    22 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    8 adult male 30day    6 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    14 embryo 06-08hr  (40) embryo 08-10hr  (48) embryo 10-12hr  (39) embryo 12-14hr  (41) embryo 14-16hr    24 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    9 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    18 white prepupae new    22 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    8 adult male 30day    6 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    14 embryo 06-08hr    40 embryo 08-10hr    48 embryo 10-12hr    39 embryo 12-14hr    41 embryo 14-16hr    24 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    9 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    18 white prepupae new    22 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    8 adult male 30day    6 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    5 embryo 04-06hr    14 embryo 06-08hr    40 embryo 08-10hr    48 embryo 10-12hr    39 embryo 12-14hr    41 embryo 14-16hr    24 embryo 16-18hr    17 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    9 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    18 white prepupae new    22 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    8 adult male 30day    6 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    8 embryonic S1    1 embryonic S3    8 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    5 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    6 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    42 ovary OSC    64 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    8 embryonic S1    1 embryonic S3    8 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    5 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    6 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS  (42) ovary OSC  (64) ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    8 embryonic S1    1 embryonic S3    8 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    5 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    6 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    42 ovary OSC    64 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    8 embryonic S1    1 embryonic S3    8 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    5 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    6 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    42 ovary OSC    64 ovary OSS    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    8 embryonic S1    1 embryonic S3    8 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    5 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    6 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    42 ovary OSC    64 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    8 embryonic S1    1 embryonic S3    8 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    5 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    6 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS  (42) ovary OSC  (64) ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    8 embryonic S1    1 embryonic S3    8 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    5 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    6 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    42 ovary OSC    64 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    8 embryonic S1    1 embryonic S3    8 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    5 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    6 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    42 ovary OSC    64 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • RE72345 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025525 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9102-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL432B bab24.Scer\UAS lethal, with Scer\GAL4T80 bab24.Scer\UAS partially lethal - majority die, with Scer\GAL4hs.PB bab24.Scer\UAS viable, with Scer\GAL4pnr-MD237 bab2GD1381 bab2GD17091 Sterility Allele female fertile bab2E6 female sterile | recessive bab2E1 bab2E4 bab2E5 Other Phenotypes Allele body color defective, with Scer\GAL430A bab24.Scer\UAS body color defective, with Scer\GAL4hs.PB bab24.Scer\UAS body color defective, with Scer\GAL4p339 bab24.Scer\UAS body color defective, with Scer\GAL4pnr-MD237 bab2GD17091 body color defective | dominant | male bab2ftz-f1-66.3 body color defective | female bab2D1 body color defective | female | recessive bab2E1 bab2E3 body color defective | male, with Scer\GAL4C-765 bab24.Scer\UAS body color defective | male, with Scer\GAL4pnr-MD237 bab24.Scer\UAS visible, with Scer\GAL430A bab24.Scer\UAS visible, with Scer\GAL471B bab24.Scer\UAS visible, with Scer\GAL4bab1-Pgal4-1 bab24.Scer\UAS visible, with Scer\GAL4p339 bab24.Scer\UAS visible, with Scer\GAL4upd-E132 bab24.Scer\UAS visible | dominant bab2E1 visible | dominant | male bab2ftz-f1-66.3 visible | male, with Scer\GAL4C-765 bab24.Scer\UAS visible | male, with Scer\GAL4pnr-MD237 bab24.Scer\UAS visible | recessive bab2E1 bab2E3 bab2E4 bab2E5 bab2E6 Phenotype manifest in Allele abdominal sternite 6 & macrochaeta | male, with Scer\GAL4C-765 bab24.Scer\UAS abdominal sternite 6 & trichome | male, with Scer\GAL4C-765 bab24.Scer\UAS abdominal sternite 6 | male, with Scer\GAL4C-765 bab24.Scer\UAS abdominal sternite 7 | ectopic | male, with Scer\GAL4C-765 bab24.Scer\UAS abdominal tergite 5 | female bab2D1 bab2E1 bab2E3 abdominal tergite 6 & macrochaeta | male, with Scer\GAL4C-765 bab24.Scer\UAS abdominal tergite 6 & trichome | male, with Scer\GAL4C-765 bab24.Scer\UAS abdominal tergite 6 | female bab2D1 bab2E1 bab2E3 abdominal tergite 6 | male, with Scer\GAL4C-765 bab24.Scer\UAS abdominal tergite 7 | ectopic | male, with Scer\GAL4C-765 bab24.Scer\UAS abdominal tergite 7 | female bab2D1 adult abdomen & cuticle, with Scer\GAL430A bab24.Scer\UAS adult abdomen & cuticle, with Scer\GAL4p339 bab24.Scer\UAS adult abdominal segment 4, with Scer\GAL4hs.PB bab24.Scer\UAS adult abdominal segment 5, with Scer\GAL4hs.PB bab24.Scer\UAS adult abdominal segment 6, with Scer\GAL4hs.PB bab24.Scer\UAS adult cuticle & abdominal segment 5 | male bab2ftz-f1-66.3 adult cuticle & abdominal segment 6 | male bab2ftz-f1-66.3 adult cuticle & abdominal segment | male, with Scer\GAL4pnr-MD237 bab24.Scer\UAS antenna bab2E1 arista, with Scer\GAL4upd-E132 bab24.Scer\UAS basal cylinder, with Scer\GAL4upd-E132 bab24.Scer\UAS embryonic/larval dorsal vessel bab2unspecified haltere, with Scer\GAL4upd-E132 bab24.Scer\UAS leg bab2E1 bab2E3 bab2E4 bab2E5 bab2E6 leg, with Scer\GAL4upd-E132 bab24.Scer\UAS mesothoracic tergum, with Scer\GAL4pnr-MD237 bab2GD17091 ovariole bab2E1 bab2E4 bab2E5 ovary bab2E1 bab2E3 bab2E4 bab2E5 bab2E6 prothoracic tarsal segment 2 bab2E1 tarsal segment, with Scer\GAL430A bab24.Scer\UAS tarsal segment, with Scer\GAL4p339 bab24.Scer\UAS tarsal segment | ectopic, with Scer\GAL4upd-E132 bab24.Scer\UAS tergite, with Scer\GAL471B bab24.Scer\UAS tergite, with Scer\GAL4bab1-Pgal4-1 bab24.Scer\UAS tergite, with Scer\GAL4hs.PB bab24.Scer\UAS terminal filament bab2E6 wing, with Scer\GAL430A bab24.Scer\UAS wing, with Scer\GAL471B bab24.Scer\UAS wing, with Scer\GAL4p339 bab24.Scer\UAS wing, with Scer\GAL4upd-E132 bab24.Scer\UAS wing disc, with Scer\GAL4upd-E132 bab24.Scer\UAS wing hinge, with Scer\GAL4upd-E132 bab24.Scer\UAS
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of bab2 Class Mutagen Stocks Known lesion bab2Ar07 1 -- bab2f01557 piggyBac transposase 1 -- bab2f03000 piggyBac transposase 1 -- bab2f06956 piggyBac transposase 1 -- bab2D1 0 -- bab2E1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes bab2E3 ethyl methanesulfonate 0 -- bab2E4 ethyl methanesulfonate 0 Yes bab2E5 ethyl methanesulfonate 0 Yes bab2E6 ethyl methanesulfonate 0 -- bab2F33.8 spontaneous 0 Yes bab2Fpa1 gamma ray 0 Yes bab2ftz-f1-66.3 P-element activity 0 Yes bab2PR72 Delta2-3 0 -- bab2PRDS Delta2-3 0 -- bab2unspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of bab2 Class Mutagen Stocks Known lesion bab2GD17091 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes bab2GD1381 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bab2GLV21085 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bab2T:Avic\GFP-SF,T:Zzzz\FLAG,T:Zzzz\PSP.CS,T:Zzzz\TEV.CS,T:Zzzz\BLRP in vitro construct - coding region fusion 1 Yes bab22.Scer\UAS in vitro construct - regulatory fusion 0 Yes bab24.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)4231 (Wei et al., 2003) Df(3L)babAr07 (Kopp et al., 2000) Df(3L)babPR72 (Couderc et al., 2002) Df(3L)babPRDS (Couderc et al., 2002) Df(3L)Fpa1 (Couderc et al., 2002) Df(3L)Fpa2 (Couderc et al., 2002)
Not disrupted in	Df(3L)Fpa1 (Wei et al., 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1381} NA P{GD17091} NA P{TRiP.GLV21085} NA P{UAS-bab2.2} NA P{UAS-bab2.4} NA characterization construct PBac{bab2-GFP.FPTB} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{Ecol\lacO.256x.w}157.4.112 NA P{UAS-bab2.4}ftz-f166.3 NA PBac{WH}bab2f01557 NA PBac{WH}bab2f03000 NA PBac{WH}bab2f06956 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
AT DNA binding inferred from direct assay (Lours et al., 2003) protein binding inferred from physical interaction with bip2 (Pointud et al., 2001)
Biological Process
CV term Evidence References
female gonad development inferred from genetic interaction with bab1 AND inferred from mutant phenotype (assigned by UniProtKB) (Couderc et al., 2002) imaginal disc-derived leg morphogenesis inferred from genetic interaction with bab1 AND inferred from mutant phenotype (assigned by UniProtKB) (Couderc et al., 2002) transcription, DNA-dependent inferred from expression pattern (assigned by UniProtKB) (Couderc et al., 2002)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Lours et al., 2003) polytene chromosome inferred from direct assay (Lours et al., 2003) NOT polytene chromosome chromocenter inferred from direct assay (Lours et al., 2003)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Lehmann, 2002.7.1) sequence-specific DNA binding transcription factor activity traceable author statement (Christiansen et al., 2002)
Biological Process
CV term Evidence References
eye-antennal disc morphogenesis inferred from sequence or structural similarity (assigned by UniProtKB) (Couderc et al., 2002) regulation of transcription, DNA-dependent traceable author statement (Christiansen et al., 2002)
Cellular Component
CV term Evidence References
nucleus traceable author statement (assigned by UniProtKB) (Couderc et al., 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions bab2 allele Gene References bab2Ar07 bab1 (Kopp et al., 2000, Couderc et al., 2002) bab2PR72 bab1 (Couderc et al., 2002) bab2PRDS bab1 (Couderc et al., 2002) unspecified abd-A (Kopp et al., 2000) Abd-B (Kopp et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68922 DroID - A comprehensive database of gene and protein interactions. • FBgn0025525 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44254
Orthologs
OrthoDB Orthologs (90) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63BN8F Dipteran inclusive ortholog search EOG62V8RH Insect inclusive ortholog search EOG6280X1 Arthropod inclusive ortholog search EOG608KQF Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG63BN8F)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\bab2     Drosophila simulans   Dsim\GD22238     Drosophila simulans   Dsim\GD13495 Y   Drosophila sechellia   Dsec\GM14235     Drosophila erecta   Dere\GG14622 Y   Drosophila yakuba   Dyak\GE20983 Y   Drosophila ananassae   Dana\GF10078 Y   Drosophila willistoni   Dwil\GK16859     Drosophila virilis   Dvir\GJ12695     Drosophila mojavensis   Dmoj\GI12710 Y   Drosophila grimshawi   Dgri\GH15666
Orthologs in non-Drosophila Dipterans (EOG62V8RH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001739 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011216 Y
Orthologs in non-Dipteran Insects (EOG6280X1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47057 Y Apis mellifera Western honey bee  Amel\GB49382 Y Apis mellifera Western honey bee  Amel\GB41167 Y Apis mellifera Western honey bee  Amel\LOC725311 Y Apis mellifera Western honey bee  Amel\GB47059 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011566 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009116 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010467 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008240 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11228 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14438 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25151 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21314 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16281 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16282 Y Atta cephalotes Leafcutter ant  Acep\ACEP16657 Y Atta cephalotes Leafcutter ant  Acep\ACEP19771 Y Atta cephalotes Leafcutter ant  Acep\ACEP15239 Y Atta cephalotes Leafcutter ant  Acep\ACEP16653 Y Atta cephalotes Leafcutter ant  Acep\ACEP16670 Y Atta cephalotes Leafcutter ant  Acep\ACEP26315 Y Atta cephalotes Leafcutter ant  Acep\ACEP25847 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO17419 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13831 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO22974 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19190 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO17933 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19143 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14972 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15302 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21900 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12465 Y Linepithema humile Argentine ant  Lhum\LH21661 Y Linepithema humile Argentine ant  Lhum\LH16826 Y Linepithema humile Argentine ant  Lhum\LH13615 Y Linepithema humile Argentine ant  Lhum\LH21665 Y Linepithema humile Argentine ant  Lhum\LH19143 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11625 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24935 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11637 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11638 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB16867 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11942 Y Solenopsis invicta Red fire ant  Sinv\SINV15582 Y Solenopsis invicta Red fire ant  Sinv\SINV16487 Y Solenopsis invicta Red fire ant  Sinv\SINV13243 Y Solenopsis invicta Red fire ant  Sinv\SINV13240 Y Solenopsis invicta Red fire ant  Sinv\SINV15809 Y Solenopsis invicta Red fire ant  Sinv\SINV13628 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004381 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002482 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI087848 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004069 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001210 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007530 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007531 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012231 Y Pediculus humanus Human body louse  Phum\PHUM595780 Y Pediculus humanus Human body louse  Phum\PHUM228760 Y Pediculus humanus Human body louse  Phum\PHUM088440 Y Pediculus humanus Human body louse  Phum\PHUM088430 Y Pediculus humanus Human body louse  Phum\PHUM489940 Y Pediculus humanus Human body louse  Phum\PHUM537020 Y Tribolium castaneum Red flour beetle  Tcas\TC009535 Y Tribolium castaneum Red flour beetle  Tcas\TC013842 Y Tribolium castaneum Red flour beetle  Tcas\TC013843 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_07162 Y Tribolium castaneum Red flour beetle  Tcas\TC003621 Y
Orthologs in non-Insect Arthropods (EOG608KQF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ACSBG1 Y Daphnia pulex Water flea  Dpux\Sld5 Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\JGI_V11_347243 Y Daphnia pulex Water flea  Dpux\TwdlJ Y Ixodes scapularis Deer tick  Isca\ISCW016371 Y Ixodes scapularis Deer tick  Isca\ISCW010367 Y Ixodes scapularis Deer tick  Isca\ISCW016996 Y Ixodes scapularis Deer tick  Isca\ISCW019463 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (6) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13495 Drosophila erecta Dere\GG14622 Drosophila yakuba Dyak\GE20983 Drosophila ananassae Dana\GF10078 Drosophila persimilis Dper\GL25461 Drosophila mojavensis Dmoj\GI12710
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	38628 w1118; PBac{bab2-GFP.FPTB}VK00037/SM5 35720 y1 sc* v1; P{TRiP.GLV21085}attP2 37298 Df(3L)babAr07, bab1Ar07 bab2Ar07/TM6B, Tb1
Harvard	- PBac{WH}bab2f01557 - PBac{WH}bab2f03000 - PBac{WH}bab2f06956
VDRC	v8943 w1118; P{GD1381}v8943 v49042 w1118; P{GD17091}v49042 v49043 w1118; P{GD17091}v49043/TM3
Genomic Clones ( 1 )
	BACR22D12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 170 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP14464 RE72345
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT25571 RE45055 RE53763 RE72880 RH06941 RH06949 RH30020 RH30716 RH36065 RH43693 RH51859 RH63577 RH70341 SD14952 SD20610 SD22651
Other clones	30685 32414 41927 44776 47806 51325 60438 62574 122256 152897 162247 280385 281639 CK01.14C.C12 CK01.38D.E5 CK01.117A.B6 CK01358 CK01771 CK01836 CK02216 CK02256 CK02684 CK02693 EK005430 EK032719 EK040554 EK053803 EK057316 EK059327 EK060011 EK062229 EK062839 EK084963 EK090809 EK092643 EK093145 EK095703 EK097007 EK100937 EK102527 EK105244 EK106046 EK106728 EK109250 EK110833 EK112136 EK119043 EK128624 EK135752 EK140934 EK143704 EK144714 EK146664 EK148339 EK153953 EK155331 EK155537 EK156329 EK157360 EK158856 EK159163 EK162051 EK166125 EK166349 EK167802 EK168941 EK175760 EK176904 EK178232 EK179526 EK183708 EK184516 EK184927 EK186020 EK188252 EK188604 EK197806 EK197836 EK200229 EK207145 EK207953 EK208757 EK209943 EK213836 EK220109 EK224049 EK230464 EK234764 EK241457 EK245212 EK245728 EK245947 EK256249 EK259242 EK262215 EK263921 EK264004 EK265721 EK284052 EK290234 EK291606 EK293141 EK298525 EK301608 EK301618 EK302908 EK305264 EK307014 EN12324 EP00644 EP00647 EP01622 EP03007 EP03024 EP03318 EP03630 EP05010 EP05631 EP09350 EP10112 EP11538 EP12425 EP13216 EP13712 EP14817 EP18140 EP18609 EP19647 EP22363 GH03238 RP003052298 RP003145053 RP003146671 RP003168499 RP003191763 RP003205633 RP003210205 RP003231737 RP003254440 RP003263051 RP003278077 RP003281455 RP003316695 RP003344357 RP003387942 RP003398446 RP003488734 RP003538120 RP003574248 RP003615010 RP003640531 RP003651310
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025525 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44254
Antibody Information
	polyclonal (Couderc et al., 2002, Couderc et al., 2002)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: BtbII CG13911 (Couderc et al., 2002, FlyBase Genome Annotators, 2002-2003)
Additional comments	Annotations CG9102 and CG13911 merged as CG9102 in release 3 of the genome annotation. (Couderc et al., 2002, FlyBase Genome Annotators, 2002-2003)
Other Comments
	bab1 and bab2 are both required for normal development. The functions of bab1 and bab2 show both redundant and divergent aspects, with bab2 playing a predominant role in exerting "bab" function. Both bab1 and bab2 are required for normal ovarian development, but loss-of-function of bab2 causes a more severe ovarian phenotype. There is an overlapping but differential requirement for bab1 and bab2 in the pigmentation of different adult abdominal segments, with A7 being more dependent on bab1 and A5 being more dependent on bab2 activity. Only bab2 plays an essential role in leg development; a bab1 mutant does not cause a mutant leg phenotype, whereas even weak bab2 mutants show leg defects. The strongest defects in ovaries, legs and abdomen that are associated with the "bab" locus are only seen in mutants that are null for both bab1 and bab2. (Couderc et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079155 NM_001274313 RefSeq (Proteins) • NP_523879 NP_001261242 DDBJ / EMBL / GenBank • AAA50834 AAF47442 AAQ22432 AGB93937 AJ252173 BI578471 BT009963 CAB64388 CZ484021 CZ485557 CZ489697 CZ489698 U14399 Entrez Gene - A searchable database of RefSeq genes. • 44254 UniProtKB/Swiss-Prot • Q9W0K4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) DNA binding HTH domain, Psq-type (IPR007889) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Homeodomain-like (IPR009057) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE72345
Linkouts
	BioGRID - A database of protein and genetic interactions • 68922 DroID - A comprehensive database of gene and protein interactions. • FBgn0025525 DRSC - Results from RNAi screens. • FBgn0025525 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025525 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9102-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025525 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44254 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44254 modMine - Data generated by the modENCODE project. • FBgn0025525 REDfly - A database of transcriptional regulatory elements. • FBgn0025525
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	bab (Hatini et al., 2005, Wittkopp et al., 2003, Chen et al., 2001, Kopp et al., 2003, Galindo et al., 2002, Williams et al., 2003, Burtis, 2002, Panganiban and Rubenstein, 2002, Galindo et al., 2002, Campbell and Tomlinson, 1998, Keller, 2006, Jeong et al., 2006, Ebacher et al., 2007, Gibert et al., 2007, Greenberg and Hatini, 2009, Pueyo and Couso, 2011) BAB (Dey et al., 2009) BAB2 (Pointud et al., 2001) bab2 (Jeong et al., 2006, Bickel et al., 2008, Loncle et al., 2007, Williams et al., 2008, Weake et al., 2011, Junion et al., 2007, Greenberg and Hatini, 2009, Wei et al., 2003, Spokony and White, 2012.5.22, Bickel et al., 2011, Cherbas et al., 2011, Chatterjee et al., 2011, Bickel et al., 2009, Randsholt and Santamaria, 2008) Bab2 (Haag-Liautard et al., 2007, Bannina and Kopp, 2007, Kennell et al., 2012, Tokusumi et al., 2012) bab-II (Christiansen et al., 2002, Siegmund and Lehmann, 2002, Pointud et al., 1999, Pointud, 1998.9.23, Pointud et al., 1998, ) BTB-II (Laski, 1994.9.5, Zollman et al., 1994) BtbII   CG9102 (Ni et al., 2011.7.19) CG13911
Name Synonym	bab2   bric-a-brac (Garvey et al., 2005, Ebacher et al., 2007, Gibert et al., 2007, Bickel et al., 2011) bric a brac (Lehmann, 2004, Wittkopp et al., 2003, Keller, 2006, Bannina and Kopp, 2007) Bric a brac (Dey et al., 2009) bric-a-brac2 (Christiansen and Baker, 2005) bric-a-brac-2 (Loncle et al., 2007) bric-a-brac 2 (Greenberg and Hatini, 2009) bric a brac 2 (Bickel et al., 2009) Bric-a-brac 2 (Felix et al., 2012) bric a brac II (Pointud et al., 1998) Bric a brac II (Cho et al., 2005) BTB-protein-II
Secondary FlyBase IDs
	FBgn0012044 FBgn0035185
References ( 82 )
Generate a list of	All references relating to this gene ( 82 )
List References by type	Research paper  ( 44 ) Supplementary material  ( 5 ) Review  ( 7 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 8 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 11 )
	Felix et al., 2012, Genetics 191(3): 989--1002 Age-Specific Variation in Immune Response in Drosophila melanogaster Has a Genetic Basis. [FBrf0218944] Green and Extavour, 2012, Dev. Biol. 372(1): 120--130 Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila. [FBrf0219715] Kennell et al., 2012, Dev. Dyn. 241(1): 161--168 The MicroRNA miR-8 is a positive regulator of pigmentation and eclosion in Drosophila. [FBrf0216982] Tokusumi et al., 2012, PLoS ONE 7(7): e41604 Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204] Zeng et al., 2012, Nucleic Acids Res. 40(13): 5848--5863 Genome-wide polycomb target gene prediction in Drosophila melanogaster. [FBrf0218974] Bickel et al., 2011, PLoS Genet. 7(1): e1001275 Composite Effects of Polymorphisms near Multiple Regulatory Elements Create a Major-Effect QTL. [FBrf0212845] Chatterjee et al., 2011, Development 138(6): 1099--1109 The female-specific Doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. [FBrf0213054] Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Gibert et al., 2011, PLoS Genet. 7(1): e1001280 Segregating Variation in the Polycomb Group Gene cramped Alters the Effect of Temperature on Multiple Traits. [FBrf0212864] Pueyo and Couso, 2011, Dev. Biol. 355(2): 183--193 Tarsal-less peptides control Notch signalling through the Shavenbaby transcription factor. [FBrf0213970] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...