FB2019_05, released Oct 15, 2019

Gene: Dmel\Pli

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General Information
Symbol
Dmel\Pli
Species
D. melanogaster
Name
Pellino
Annotation Symbol
CG5212
Feature Type
protein_coding_gene
FlyBase ID
FBgn0025574
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Snapshot
Pellino (Pli) encodes a RING-domain-containing ubiquitin E3 ligase that coordinates with ubiquitin-activating (E1) and ubiquitin-conjugating (E2) enzymes to degrade target proteins. It functions as a negative regulator of the Toll-mediated innate immunity pathway. [Date last reviewed: 2018-10-18]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
95C5-95C8
Sequence location
3R:23,860,162..23,890,052 [-]
Recombination map
3-81
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the pellino family. (O77237)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
kinase regulator activity; protein binding; ubiquitin-protein transferase activity
Predictions / Assertions
ubiquitin protein ligase activity
Summaries
Gene Group (FlyBase)
OTHER RING DOMAIN UBIQUITIN LIGASES -
The RING (Really Interesting New Gene) finger domain co-ordinates two Zn2+ ions via conserved Cys and His residues. Most proteins which contain a RING finger are assumed to be ubiquitin (E3) ligases. The RING finger binds ubiquitin-conjugating enzymes (E2) and promotes direct transfer of ubiquitin to the target protein. (Adapted from FBrf0215242 and PMID:19489725).
Pathway (FlyBase)
Negative Regulators of Toll-NF-KappaB Signaling Pathway -
In Drosophila, the canonical Toll signaling pathway is initiated by the binding of a spatzle ligand to Toll (Tl) or a Toll-like receptor leading to the nuclear localization of the NF-κB (dl or Dif) transcription factor. Negative regulators of Toll-NF-κB Signaling lead to the increased cytosolic retention of the NF-κB proteins dl or Dif and/or repression of target gene transcription. (Adapted from FBrf0091014 and FBrf0223077).
Positive Regulators of Toll-NF-KappaB Signaling Pathway -
In Drosophila, the canonical Toll signaling pathway is initiated by the binding of a spatzle ligand to Toll (Tl) or a Toll-like receptor leading to the nuclear localization of the NF-κB (dl or Dif) transcription factor. Positive regulators of Toll-NF-κB Signaling lead to the increased nuclear accumulation of the NF-κB proteins and regulated expression of target genes. (Adapted from FBrf0091014 and FBrf0223077).
Protein Function (UniProtKB)
Scaffold protein involved in the Toll signaling pathway via its interaction with pelle/pll kinase.
(UniProt, O77237)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Pli or the JBrowse view of Dmel\Pli for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pli-RA
FBtr0084527
NM_079742
1844
424
Pli-RB
FBtr0112907
NM_001104420
2903
424
Additional Transcript Data and Comments
Reported size (kB)
3.0, 1.9 (northern blot)
(Großhans et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Pli-PA
FBpp0083913
46.8
424
7.07
NP_524466
AAF56198
Pli-PB
FBpp0111820
46.8
424
7.07
NP_001097890
ABW08739
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

424 aa isoforms: Pli-PA, Pli-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
424 (aa); 47 (kD predicted)
(Großhans et al., 1999)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with pll.
(UniProt, O77237)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pli using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (15 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
kinase regulator activity
inferred from mutant phenotype
(assigned by UniProt )
(Großhans et al., 1999)
protein binding
inferred from physical interaction with FLYBASE:pll; FB:FBgn0010441
(Großhans et al., 1999)
ubiquitin-protein transferase activity
inferred from mutant phenotype
(Ji et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
ubiquitin protein ligase activity
inferred from biological aspect of ancestor with PANTHER:PTN000949730
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
innate immune response
inferred from mutant phenotype
(Haghayeghi et al., 2010)
negative regulation of antifungal innate immune response
inferred from mutant phenotype
(Ji et al., 2014)
negative regulation of defense response to bacterium
inferred from mutant phenotype
(Ji et al., 2014)
negative regulation of Toll signaling pathway
inferred from mutant phenotype
(Ji et al., 2014)
positive regulation of antimicrobial peptide production
inferred from mutant phenotype
(Haghayeghi et al., 2010)
positive regulation of Toll signaling pathway
inferred from mutant phenotype
(Haghayeghi et al., 2010)
protein K48-linked ubiquitination
inferred from mutant phenotype
(Ji et al., 2014)
Toll signaling pathway
inferred from mutant phenotype
(assigned by UniProt )
(Großhans et al., 1999)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
protein polyubiquitination
inferred from biological aspect of ancestor with PANTHER:PTN000949730
(assigned by GO_Central )
(Gaudet et al., 2011)
Toll signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000949730
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
cytoplasmic side of plasma membrane
inferred from direct assay
(Ji et al., 2014)
cytosol
inferred from direct assay
(Ji et al., 2014)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult fat body

Comment: cyclical, peak ZT17-20

(Xu et al., 2011)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Großhans et al., 1999)
embryonic stage 1 -- 4

Comment: reference states 0-2 hr AEL

(Großhans et al., 1999)
adult stage | female
(Großhans et al., 1999)
Additional Descriptive Data
Expressed cyclically in the adult fat body.
(Xu et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Großhans et al., 1999)
embryonic stage -- adult stage
(Großhans et al., 1999)
Additional Descriptive Data
Pli protein is detected at all stages of development on western blots. It is uniformly distributed in embryos.
(Großhans et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasmic side of plasma membrane
inferred from direct assay
(Ji et al., 2014)
cytosol
inferred from direct assay
(Ji et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pli in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pli
Transgenic constructs containing regulatory region of Pli
Deletions and Duplications ( 2 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PELI1
14 of 15
Yes
Yes
 
Hsap\PELI2
14 of 15
Yes
Yes
Hsap\PELI3
13 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Peli1
13 of 15
Yes
Yes
Mmus\Peli2
13 of 15
Yes
Yes
Mmus\Peli3
12 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Peli2
13 of 13
Yes
Yes
Rnor\Peli3
11 of 13
No
Yes
Rnor\Peli1
10 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\peli1
12 of 12
Yes
Yes
Xtro\peli2
8 of 12
No
Yes
Danio rerio (Zebrafish) (5)
Drer\peli2
14 of 15
Yes
Yes
Drer\peli1b
13 of 15
No
Yes
Drer\peli3
10 of 15
No
Yes
Drer\peli1a
9 of 15
No
Yes
Drer\LOC100334245
8 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\peli-1
15 of 15
Yes
Yes
Cele\F26B1.5
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091907K2 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Pli
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011952
Drosophila simulans
Dsim\GD18346
Drosophila sechellia
Dsec\GM23534
Drosophila erecta
Dere\GG12398
Drosophila yakuba
Dyak\GE23916
Drosophila ananassae
Dana\GF18733
Drosophila pseudoobscura pseudoobscura
Dpse\GA18740
Drosophila persimilis
Dper\GL24265
Drosophila willistoni
Dwil\GK11979
Drosophila virilis
Dvir\GJ24639
Drosophila mojavensis
Dmoj\GI23056
Drosophila grimshawi
Dgri\GH10673
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504F4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17005878
Glossina morsitans
Tsetse fly
Gmor\GMOY007135
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11637
Mayetiola destructor
Hessian fly
Mdes\Mdes000097
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002420
Anopheles darlingi
American malaria mosquito
Adar\ADAC003269
Anopheles gambiae
Malaria mosquito
Agam\AGAP004232
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008269
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07GA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005063
Danaus plexippus
Monarch butterfly
Dple\DPOGS214647-PA
Heliconius melpomene
Postman butterfly
Hmel\Pellino
Apis florea
Little honeybee
Aflo\2194913924
Apis mellifera
Western honey bee
Amel\GB44935
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22875
Bombus terrestris
Buff-tailed bumblebee
Bter\15210452
Linepithema humile
Argentine ant
Lhum\LH11980
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002d61
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005756
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013130
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11826
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00006
Tribolium castaneum
Red flour beetle
Tcas\TC033602
Pediculus humanus
Human body louse
Phum\PHUM235930
Rhodnius prolixus
Kissing bug
Rpro\RPRC011811
Cimex lectularius
Bed bug
Clec\CLEC010898
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI083717
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13122
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14417
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07BD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013063
Ixodes scapularis
Black-legged tick
Isca\ISCW009827
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60757.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g04160
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307221
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0631 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pellino
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006508
Gallus gallus
Domestic chicken
Ggal\PELI2
Gallus gallus
Domestic chicken
Ggal\PELI1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PELI1; pellino E3 ubiquitin protein ligase 1
    14 of 15
    614797
         
        PELI2; pellino E3 ubiquitin protein ligase family member 2
        14 of 15
        614798
            PELI3; pellino E3 ubiquitin protein ligase family member 3
            13 of 15
            609827
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Summary of Genetic Interactions
                esyN Network Diagram
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                External Data
                Subunit Structure (UniProtKB)
                Interacts with pll.
                (UniProt, O77237 )
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Gene Group - Pathway Membership (FlyBase)
                Negative Regulators of Toll-NF-KappaB Signaling Pathway -
                In Drosophila, the canonical Toll signaling pathway is initiated by the binding of a spatzle ligand to Toll (Tl) or a Toll-like receptor leading to the nuclear localization of the NF-κB (dl or Dif) transcription factor. Negative regulators of Toll-NF-κB Signaling lead to the increased cytosolic retention of the NF-κB proteins dl or Dif and/or repression of target gene transcription. (Adapted from FBrf0091014 and FBrf0223077).
                Positive Regulators of Toll-NF-KappaB Signaling Pathway -
                In Drosophila, the canonical Toll signaling pathway is initiated by the binding of a spatzle ligand to Toll (Tl) or a Toll-like receptor leading to the nuclear localization of the NF-κB (dl or Dif) transcription factor. Positive regulators of Toll-NF-κB Signaling lead to the increased nuclear accumulation of the NF-κB proteins and regulated expression of target genes. (Adapted from FBrf0091014 and FBrf0223077).
                External Data
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map
                3-81
                Cytogenetic map
                95C5-95C8
                Sequence location
                3R:23,860,162..23,890,052 [-]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                95C5-95C8
                Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                95C4-95C6
                (Großhans, 1998.9.10)
                95C-95C
                (Großhans et al., 1999)
                Experimentally Determined Recombination Data
                Location
                3-81
                (FlyBase, 2016)
                3-82.3
                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (17)
                Genomic Clones (28)
                cDNA Clones (141)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequences
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                polyclonal
                (Ji et al., 2014, Großhans et al., 1999)
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of
                Source for identity of: Pli CG5212
                (Kodira, 1999.11)
                Source for database merge of
                Additional comments
                Other Comments
                Pli acts a negative regulator of Tl-mediated innate immune signalling by controlling turnover of Myd88.
                (Ji et al., 2014)
                Identification: Two hybrid yeast screen with pll protein as a binding partner.
                (Großhans et al., 1999)
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 42 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DPiM - Drosophila Protein interaction map
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyMine - An integrated database for Drosophila genomics
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Synonyms and Secondary IDs (8)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (54)