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Gene Dmel\Pli

General Information
Symbol	Dmel\Pli	Species	D. melanogaster
Name	Pellino	Annotation symbol	CG5212
Feature type	protein_coding_gene	FlyBase ID	FBgn0025574
Gene Model Status	Current	Stock availability	11 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	95C5-95C8	Sequence location	3R:19,685,884..19,715,774 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Pellino is referred to in FlyBase by the symbol Dmel\Pli (CG5212, FBgn0025574). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: kinase regulator activity. There is experimental evidence that it is involved in the biological process: Toll signaling pathway; regulation of phosphorylation. 17 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Pellino family. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval midgut, larval hindgut, adult Malpighian tubules, larval/adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1626980_at completely aligns to an exonic region of only a subset of 2 of the 3 FlyBase-annotated transcript isoforms of Pli. Gene sequence location is 3R:19685884..19715774.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95C5-95C8   Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
Experimentally Determined Cytological Location
Cytogenetic map Notes References 95C4-95C6     (Grosshans, 1998.9.10) 95C-95C     (Grosshans et al., 1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pli for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pli-RA FBtr0084527  NM_079742   1844   424 Pli-RB FBtr0112907  NM_001104420   2903   424
Additional Transcript Data & Comments
Reported size (kB)	3.0, 1.9 (northern blot) (Grosshans et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pli-PA   FBpp0083913   46.8   424   7.07     NP_524466   AAF56198 Pli-PB   FBpp0111820   46.8   424   7.07     NP_001097890   ABW08739
Additional Polypeptide Data & Comments
Reported size (kDa)	424 (aa); 47 (kD predicted) (Grosshans et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Pellino family (IPR006800)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202810   AA390303   AA391886   AA438859   AA438861   AE014297 AAF56198   AE014297 ABW08739   AF091624 AAC96298   AI514334   AY060931   AY069632 AAL39777   BH615025   BI162879   BI167618   BI169960   BI172231   BI173629   BI213563   BI214010   BI215777   BI228073   BI228739   BI229719   BI230290   BI234860   BI236001   BI238303   BI239266   BI239603   BI240806   BI241014   BI242816   BI242873   BI352988   BI356878   BI358139   BI363398   BI364982   BI365089   BI369626   BI374834   BI483142   BI483245   BI483333   BI487209   BT089010   CO177921   CO178100   CO179139   CO186734   CO187513   CO189233   CO189522   CO190285   CO192868   CO263725   CO264527   CO265687   CO267514   CO267571   CO267716   CO270027   CO270386   CO272403   CO277765   CO278730   CO282070   CO282775   CO285211   CO289654   CO290271   CO290744   CO293990   CO294233   CO295302   CO296040   CO296459   CO301565   CO305694   CO306955   CO312362   CO314117   CO317256   CO322851   CO330251   CO332390   CO339239   CO339609   CO342093   CO344120   CZ467310   CZ481423   CZ482952   DN153835   EC053797   EC057501   EC059508   EC059715   EC060930   EC064136   EC065984   EC067459   EC068900   EC070304   EC070944   EC075661   EC076199   EC077473   EC080016   EC080850   EC083257   EC085455   EC086965   EC088244   EC088780   EC089375   EC090433   EC090612   EC194539   EC196991   EC198576   EC199556   EC201714   EC207309   EC212709   EC215346   EC215440   EC218537   EC219254   EC222074   EC222076   EC222775   EC224698   EC231509   EC241182   EC243527   EC244502   EC245069   EC245112   EC246095   EC246518   EC251527   EC252496   EC253513   EC257886   EV578103   EV578252   EV579716   EV589432
UniProtKB/Swiss-Prot	O77237
UniProtKB/TrEMBL	A8JR89
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Grosshans et al., 1999) embryonic stage 1 -- 4     (Grosshans et al., 1999) Comment:reference states 0-2 hr AEL adult stage | female     (Grosshans et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Grosshans et al., 1999) embryonic stage -- adult stage     (Grosshans et al., 1999)
Additional Descriptive Data
	Pli protein is detected at all stages of development on western blots. It is uniformly distributed in embryos. (Grosshans et al., 1999)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval midgut, larval hindgut, adult Malpighian tubules, larval/adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    211.925 Larval Midgut    195.9 Larval Hindgut    178.3 Larval Malpighian Tubules    847.9 Larval Fat Body    475 Larval Salivary Gland    54.7 Larval Trachea    62.275 Larval Carcass    80.025 Adult Head    168.9 Adult Eye    431 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    190.2 Adult Crop    77.7 Adult Midgut    82.8 Adult Hindgut    86.7 Adult Malpighian Tubules    260.4 Adult Fat Body    215.6 Adult Salivary Gland    116.1 Adult Heart    99.075 Adult VirginFemale Spermatheca    104.5 Adult InseminatedFemale Spermatheca    177.5 Adult Ovary    102.3 Adult Testis    20.8 Adult Male Accessory Gland    151.7 Adult Carcass    86.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    211.925 Larval Midgut    195.9 Larval Hindgut    178.3 Larval Malpighian Tubules  (847.9) Larval Fat Body    475 Larval Salivary Gland    54.7 Larval Trachea    62.275 Larval Carcass    80.025 Adult Head    168.9 Adult Eye    431 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    190.2 Adult Crop    77.7 Adult Midgut    82.8 Adult Hindgut    86.7 Adult Malpighian Tubules    260.4 Adult Fat Body    215.6 Adult Salivary Gland    116.1 Adult Heart    99.075 Adult VirginFemale Spermatheca    104.5 Adult InseminatedFemale Spermatheca    177.5 Adult Ovary    102.3 Adult Testis    20.8 Adult Male Accessory Gland    151.7 Adult Carcass    86.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    211.925 Larval Midgut    195.9 Larval Hindgut    178.3 Larval Malpighian Tubules    847.9 Larval Fat Body    475 Larval Salivary Gland    54.7 Larval Trachea    62.275 Larval Carcass    80.025 Adult Head    168.9 Adult Eye    431 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    190.2 Adult Crop    77.7 Adult Midgut    82.8 Adult Hindgut    86.7 Adult Malpighian Tubules    260.4 Adult Fat Body    215.6 Adult Salivary Gland    116.1 Adult Heart    99.075 Adult VirginFemale Spermatheca    104.5 Adult InseminatedFemale Spermatheca    177.5 Adult Ovary    102.3 Adult Testis    20.8 Adult Male Accessory Gland    151.7 Adult Carcass    86.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    211.925 Larval Midgut    195.9 Larval Hindgut    178.3 Larval Malpighian Tubules    847.9 Larval Fat Body    475 Larval Salivary Gland    54.7 Larval Trachea    62.275 Larval Carcass    80.025 Adult Head    168.9 Adult Eye    431 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    190.2 Adult Crop    77.7 Adult Midgut    82.8 Adult Hindgut    86.7 Adult Malpighian Tubules    260.4 Adult Fat Body    215.6 Adult Salivary Gland    116.1 Adult Heart    99.075 Adult VirginFemale Spermatheca    104.5 Adult InseminatedFemale Spermatheca    177.5 Adult Ovary    102.3 Adult Testis    20.8 Adult Male Accessory Gland    151.7 Adult Carcass    86.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    211.925 Larval Midgut    195.9 Larval Hindgut    178.3 Larval Malpighian Tubules    847.9 Larval Fat Body    475 Larval Salivary Gland    54.7 Larval Trachea    62.275 Larval Carcass    80.025 Adult Head    168.9 Adult Eye    431 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    190.2 Adult Crop    77.7 Adult Midgut    82.8 Adult Hindgut    86.7 Adult Malpighian Tubules    260.4 Adult Fat Body    215.6 Adult Salivary Gland    116.1 Adult Heart    99.075 Adult VirginFemale Spermatheca    104.5 Adult InseminatedFemale Spermatheca    177.5 Adult Ovary    102.3 Adult Testis    20.8 Adult Male Accessory Gland    151.7 Adult Carcass    86.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    211.925 Larval Midgut    195.9 Larval Hindgut    178.3 Larval Malpighian Tubules  (847.9) Larval Fat Body    475 Larval Salivary Gland    54.7 Larval Trachea    62.275 Larval Carcass    80.025 Adult Head    168.9 Adult Eye    431 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    190.2 Adult Crop    77.7 Adult Midgut    82.8 Adult Hindgut    86.7 Adult Malpighian Tubules    260.4 Adult Fat Body    215.6 Adult Salivary Gland    116.1 Adult Heart    99.075 Adult VirginFemale Spermatheca    104.5 Adult InseminatedFemale Spermatheca    177.5 Adult Ovary    102.3 Adult Testis    20.8 Adult Male Accessory Gland    151.7 Adult Carcass    86.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    211.925 Larval Midgut    195.9 Larval Hindgut    178.3 Larval Malpighian Tubules    847.9 Larval Fat Body    475 Larval Salivary Gland    54.7 Larval Trachea    62.275 Larval Carcass    80.025 Adult Head    168.9 Adult Eye    431 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    190.2 Adult Crop    77.7 Adult Midgut    82.8 Adult Hindgut    86.7 Adult Malpighian Tubules    260.4 Adult Fat Body    215.6 Adult Salivary Gland    116.1 Adult Heart    99.075 Adult VirginFemale Spermatheca    104.5 Adult InseminatedFemale Spermatheca    177.5 Adult Ovary    102.3 Adult Testis    20.8 Adult Male Accessory Gland    151.7 Adult Carcass    86.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    211.925 Larval Midgut    195.9 Larval Hindgut    178.3 Larval Malpighian Tubules    847.9 Larval Fat Body    475 Larval Salivary Gland    54.7 Larval Trachea    62.275 Larval Carcass    80.025 Adult Head    168.9 Adult Eye    431 Adult Brain    233.8 Adult Thoracic-Abdominal Ganglion    190.2 Adult Crop    77.7 Adult Midgut    82.8 Adult Hindgut    86.7 Adult Malpighian Tubules    260.4 Adult Fat Body    215.6 Adult Salivary Gland    116.1 Adult Heart    99.075 Adult VirginFemale Spermatheca    104.5 Adult InseminatedFemale Spermatheca    177.5 Adult Ovary    102.3 Adult Testis    20.8 Adult Male Accessory Gland    151.7 Adult Carcass    86.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    168.9   NA  Eye    431   NA  Brain    233.8   211.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    190.2   NA  Crop    77.7   195.9  Midgut    82.8   178.3  Hindgut    86.7   847.9  Malpighian Tubules    260.4   475  Fat Body    215.6   54.7  Salivary Gland    116.1   NA  Heart    99.075   62.275  Trachea    NA   NA  VirginFemale Spermatheca    104.5   NA  InseminatedFemale Spermatheca    177.5   NA  Ovary    102.3   NA  Testis    20.8   NA  Male Accessory Gland    151.7   80.025  Carcass    86.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    29 central nervous system, pupae P8    26 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    24 head, mated 4-day male    19 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    134 digestive system, larvae L3 wandering    116 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    43 fat body, pupae P8    30 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    29 ovary, mated 4-day female    16 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3  (29) central nervous system, pupae P8  26 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    24 head, mated 4-day male    19 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (134) digestive system, larvae L3 wandering  (116) digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae  (43) fat body, pupae P8  (30) carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female  (29) ovary, mated 4-day female    16 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    29 central nervous system, pupae P8    26 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    24 head, mated 4-day male    19 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (134) digestive system, larvae L3 wandering  (116) digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    43 fat body, pupae P8    30 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    29 ovary, mated 4-day female    16 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    29 central nervous system, pupae P8    26 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    24 head, mated 4-day male    19 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    134 digestive system, larvae L3 wandering    116 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    43 fat body, pupae P8    30 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    29 ovary, mated 4-day female    16 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    29 central nervous system, pupae P8    26 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    24 head, mated 4-day male    19 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    134 digestive system, larvae L3 wandering    116 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    43 fat body, pupae P8    30 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    29 ovary, mated 4-day female    16 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3  29 central nervous system, pupae P8  26 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    24 head, mated 4-day male    19 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (134) digestive system, larvae L3 wandering  (116) digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae  (43) fat body, pupae P8  30 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female  29 ovary, mated 4-day female    16 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    29 central nervous system, pupae P8    26 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    24 head, mated 4-day male    19 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  134 digestive system, larvae L3 wandering  116 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    43 fat body, pupae P8    30 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    29 ovary, mated 4-day female    16 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    29 central nervous system, pupae P8    26 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    24 head, mated 4-day male    19 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    134 digestive system, larvae L3 wandering    116 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    43 fat body, pupae P8    30 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    29 ovary, mated 4-day female    16 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    42 embryo 04-06hr    78 embryo 06-08hr    87 embryo 08-10hr    98 embryo 10-12hr    109 embryo 12-14hr    88 embryo 14-16hr    78 embryo 16-18hr    64 embryo 18-20hr    33 embryo 20-22hr    15 embryo 22-24hr    20 larva L1    9 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    93 white prepupae new    96 white prepupae 12hr    80 white prepupae 24hr    46 pupae 2d postWPP    33 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    13 adult male 05day    13 adult male 30day    12 adult female 01day    21 adult female 05day    28 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (47) embryo 02-04hr  (42) embryo 04-06hr  (78) embryo 06-08hr  (87) embryo 08-10hr  (98) embryo 10-12hr  (109) embryo 12-14hr  (88) embryo 14-16hr  (78) embryo 16-18hr  (64) embryo 18-20hr  (33) embryo 20-22hr    15 embryo 22-24hr    20 larva L1    9 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6  (42) larva L3 puffstage 7-9  (93) white prepupae new  (96) white prepupae 12hr  (80) white prepupae 24hr  (46) pupae 2d postWPP  (33) pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    13 adult male 05day    13 adult male 30day    12 adult female 01day    21 adult female 05day  (28) adult female 30day  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    42 embryo 04-06hr    78 embryo 06-08hr    87 embryo 08-10hr    98 embryo 10-12hr  (109) embryo 12-14hr    88 embryo 14-16hr    78 embryo 16-18hr    64 embryo 18-20hr    33 embryo 20-22hr    15 embryo 22-24hr    20 larva L1    9 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    93 white prepupae new    96 white prepupae 12hr    80 white prepupae 24hr    46 pupae 2d postWPP    33 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    13 adult male 05day    13 adult male 30day    12 adult female 01day    21 adult female 05day    28 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    42 embryo 04-06hr    78 embryo 06-08hr    87 embryo 08-10hr    98 embryo 10-12hr    109 embryo 12-14hr    88 embryo 14-16hr    78 embryo 16-18hr    64 embryo 18-20hr    33 embryo 20-22hr    15 embryo 22-24hr    20 larva L1    9 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    93 white prepupae new    96 white prepupae 12hr    80 white prepupae 24hr    46 pupae 2d postWPP    33 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    13 adult male 05day    13 adult male 30day    12 adult female 01day    21 adult female 05day    28 adult female 30day    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    42 embryo 04-06hr    78 embryo 06-08hr    87 embryo 08-10hr    98 embryo 10-12hr    109 embryo 12-14hr    88 embryo 14-16hr    78 embryo 16-18hr    64 embryo 18-20hr    33 embryo 20-22hr    15 embryo 22-24hr    20 larva L1    9 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    93 white prepupae new    96 white prepupae 12hr    80 white prepupae 24hr    46 pupae 2d postWPP    33 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    13 adult male 05day    13 adult male 30day    12 adult female 01day    21 adult female 05day    28 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (47) embryo 02-04hr  (42) embryo 04-06hr  (78) embryo 06-08hr  (87) embryo 08-10hr  (98) embryo 10-12hr  (109) embryo 12-14hr  (88) embryo 14-16hr  (78) embryo 16-18hr  (64) embryo 18-20hr  (33) embryo 20-22hr    15 embryo 22-24hr    20 larva L1    9 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6  (42) larva L3 puffstage 7-9  (93) white prepupae new  (96) white prepupae 12hr  (80) white prepupae 24hr  (46) pupae 2d postWPP  (33) pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    13 adult male 05day    13 adult male 30day    12 adult female 01day    21 adult female 05day  28 adult female 30day  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    42 embryo 04-06hr    78 embryo 06-08hr    87 embryo 08-10hr    98 embryo 10-12hr  109 embryo 12-14hr    88 embryo 14-16hr    78 embryo 16-18hr    64 embryo 18-20hr    33 embryo 20-22hr    15 embryo 22-24hr    20 larva L1    9 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    93 white prepupae new    96 white prepupae 12hr    80 white prepupae 24hr    46 pupae 2d postWPP    33 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    13 adult male 05day    13 adult male 30day    12 adult female 01day    21 adult female 05day    28 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    42 embryo 04-06hr    78 embryo 06-08hr    87 embryo 08-10hr    98 embryo 10-12hr    109 embryo 12-14hr    88 embryo 14-16hr    78 embryo 16-18hr    64 embryo 18-20hr    33 embryo 20-22hr    15 embryo 22-24hr    20 larva L1    9 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    93 white prepupae new    96 white prepupae 12hr    80 white prepupae 24hr    46 pupae 2d postWPP    33 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    13 adult male 05day    13 adult male 30day    12 adult female 01day    21 adult female 05day    28 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2    27 embryonic Kc167    28 embryonic S1    12 embryonic S3    14 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    13 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    18 ovary fGS/OSS    26 ovary OSC    20 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2  (27) embryonic Kc167  (28) embryonic S1    12 embryonic S3    14 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    13 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    18 ovary fGS/OSS  26 ovary OSC    20 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2    27 embryonic Kc167    28 embryonic S1    12 embryonic S3    14 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    13 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    18 ovary fGS/OSS    26 ovary OSC    20 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2    27 embryonic Kc167    28 embryonic S1    12 embryonic S3    14 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    13 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    18 ovary fGS/OSS    26 ovary OSC    20 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2    27 embryonic Kc167    28 embryonic S1    12 embryonic S3    14 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    13 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    18 ovary fGS/OSS    26 ovary OSC    20 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2  27 embryonic Kc167  28 embryonic S1    12 embryonic S3    14 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    13 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    18 ovary fGS/OSS  26 ovary OSC    20 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2    27 embryonic Kc167    28 embryonic S1    12 embryonic S3    14 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    13 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    18 ovary fGS/OSS    26 ovary OSC    20 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2    27 embryonic Kc167    28 embryonic S1    12 embryonic S3    14 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    10 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    13 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    18 ovary fGS/OSS    26 ovary OSC    20 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    15 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    15 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3  (30) Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    15 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    15 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    15 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    15 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3  30 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    15 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    15 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GM07040 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025574 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5212-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | P-stage | recessive Pli1 viable PliCB03040 Other Phenotypes Allele immune response defective | recessive Pli1 Phenotype manifest in Allele embryonic head | germline clone Pli1 germ band | germline clone Pli1
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of Pli Class Mutagen Stocks Known lesion PliBG02732 P-element activity 1 -- Plic01627 piggyBac transposase 1 -- Plie03671 piggyBac transposase 1 -- PliEY22798 P-element activity 1 -- Plif00483 piggyBac transposase 1 -- PliF125 1 -- PliMB07138 1 -- PliMI00302 1 -- PliUM-8033-3 1 -- Pli1 amorphic allele - genetic evidence 0 -- PliCB03040 P-element activity 0 Yes PliMB01943 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pli Class Mutagen Stocks Known lesion PliGL00524 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PliKK108736 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PliGD10540 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes PliNIG.5212R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes PliScer\UAS.cHa in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)06624 (Grosshans et al., 1999, Haghayeghi et al., 2010, Haghayeghi et al., 2010) Df(3R)Exel9014 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10540} NA P{KK108736} NA P{NIG.5212R} NA P{TRiP.GL00524} NA P{UAS-Pli.H} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}PliMI00302 NA P{GT1}PliBG02732 NA P{PTT-GB}PliCB03040 NA P{RS3}PliUM-8033-3 NA PBac{PB}Plic01627 NA PBac{RB}Plie03671 NA PBac{WH}Plif00483 NA insertion of enhancer trap P{FZ}PliF125 No insertion of mobile activating element P{EP}EP3236 NA P{EPgy2}PliEY22798 NA insertion of enhancer trap binary system Mi{ET1}PliMB01943 No Mi{ET1}PliMB07138 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
kinase regulator activity inferred from mutant phenotype (assigned by UniProtKB) (Grosshans et al., 1999)
Biological Process
CV term Evidence References
regulation of phosphorylation inferred from mutant phenotype (Grosshans et al., 1999) Toll signaling pathway inferred from mutant phenotype (assigned by UniProtKB) (Grosshans et al., 1999)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
defense response non-traceable author statement (Lemaitre, 2000.12.20) immune response traceable author statement (Schneider, 2000) signal transduction non-traceable author statement (Lemaitre, 2000.12.20) Toll signaling pathway traceable author statement (Wu and Arron, 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Pli - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - Ald anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - CG10237 experimental knowledge based (Guruharsha et al., 2011) Pli - CG11596 experimental knowledge based (Guruharsha et al., 2011) Pli - CG11980 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Pli - CG1635 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - CG16884 experimental knowledge based (Guruharsha et al., 2011) Pli - CG16885 experimental knowledge based (Guruharsha et al., 2011) Pli - CG34205 experimental knowledge based (Guruharsha et al., 2011) Pli - CG4278 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - CG6084 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - CG6724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - CG7979 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Pli - Eno anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - FK506-bp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - Mhc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - Nurf-38 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - P32 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - Prx3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - RPA2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - RhoGAP18B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - Sod2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - dock anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - l(2)37Cc anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Pli - rho-4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pli - vls anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pli allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67757 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025574 DroID - A comprehensive database of gene and protein interactions. • FBgn0025574 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42821
Orthologs
OrthoDB Orthologs (52) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6P8G3W Dipteran inclusive ortholog search EOG669R36 Insect inclusive ortholog search EOG6893H5 Arthropod inclusive ortholog search EOG634TNR Metazoa inclusive ortholog search EOG6FNHBK
Orthologs in Drosophila Species (EOG6P8G3W)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Pli     Drosophila simulans   Dsim\GD18346 Y   Drosophila sechellia   Dsec\GM23534 Y   Drosophila erecta   Dere\GG12398 Y   Drosophila yakuba   Dyak\GE23916 Y   Drosophila ananassae   Dana\GF18733 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18740 Y   Drosophila persimilis   Dper\GL24265 Y   Drosophila willistoni   Dwil\GK11979 Y   Drosophila virilis   Dvir\GJ24639 Y   Drosophila mojavensis   Dmoj\GI23056 Y   Drosophila grimshawi   Dgri\GH10673 Y
Orthologs in non-Drosophila Dipterans (EOG669R36)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002420   Anopheles gambiae Malaria mosquito  Agam\AGAP004232   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008269
Orthologs in non-Dipteran Insects (EOG6893H5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44935   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013130   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12874   Atta cephalotes Leafcutter ant  Acep\ACEP21967   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23267   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15391   Linepithema humile Argentine ant  Lhum\LH11980   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16408   Solenopsis invicta Red fire ant  Sinv\SINV14176   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001694   Acyrthosiphon pisum Pea aphid  Apim\ACYPI083717   Bombyx mori Silkmoth  Bmor\BGIBMGA005063   Pediculus humanus Human body louse  Phum\PHUM235930   Tribolium castaneum Red flour beetle  Tcas\TC001586   Tribolium castaneum Red flour beetle  Tcas\TC009672
Orthologs in non-Insect Arthropods (EOG634TNR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\HLA-B   Ixodes scapularis Deer tick  Isca\ISCW009827
Orthologs in non-Arthropod Metazoa (EOG6FNHBK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F25B4.2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004517gn   Danio rerio Zebrafish  Drer\peli2   Danio rerio Zebrafish  Drer\ENSDARG00000087452   Danio rerio Zebrafish  Drer\ENSDARG00000003041   Danio rerio Zebrafish  Drer\ENSDARG00000091592   Danio rerio Zebrafish  Drer\peli1   Xenopus tropicalis Western clawed frog  Xtro\peli2   Xenopus tropicalis Western clawed frog  Xtro\peli1   Gallus gallus Domestic chicken  Ggal\PELI2   Gallus gallus Domestic chicken  Ggal\PELI1   Mus musculus House mouse  Mmus\Peli3   Mus musculus House mouse  Mmus\Peli2   Mus musculus House mouse  Mmus\Peli1   Rattus norvegicus Norway rat  Rnor\Peli3   Rattus norvegicus Norway rat  Rnor\RGD1564594   Rattus norvegicus Norway rat  Rnor\Peli2   Homo sapiens Human  Hsap\ENSG00000174516   Homo sapiens Human  Hsap\PELI2   Homo sapiens Human  Hsap\PELI1
Human Orthologs (3)
Gene OMIM HGNC Hsap\ENSG00000174516     Hsap\PELI2     Hsap\PELI1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18346 Drosophila sechellia Dsec\GM23534 Drosophila erecta Dere\GG12398 Drosophila yakuba Dyak\GE23916 Drosophila ananassae Dana\GF18733 Drosophila pseudoobscura pseudoobscura Dpse\GA18740 Drosophila persimilis Dper\GL24265 Drosophila willistoni Dwil\GK11979 Drosophila virilis Dvir\GJ24639 Drosophila mojavensis Dmoj\GI23056 Drosophila grimshawi Dgri\GH10673
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	7316 ry506 P{FZ}PliF125 13124 w1118; P{GT1}PliBG02732 26071 w1118; Mi{ET1}PliMB07138 30696 y1 w*; Mi{MIC}PliMI00302 22585 y1 w67c23; P{EPgy2}PliEY22798 36787 y1 sc* v1; P{TRiP.GL00524}attP2
Harvard	- PBac{PB}Plic01627 - PBac{RB}Plie03671 - PBac{WH}Plif00483
Kyoto	124295 w1118; P{RS3}PliUM-8033-3
VDRC	v106776 P{KK108736}VIE-260B
Genomic Clones ( 2 )
	BACR05C11 BACR11E07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 140 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM07040 LD40134
Other clones	DPiM_LD40134 MIP12906
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM21652 LD03129 LD06313 LD10775 LD13232 LD13234 RE02144 RE08040 RE08968 RE11281 RE14537 RE16588 RE18985 RE19688 RE22381 RE25495 RE26376 RE27556 RE30628 RE31977 RE34717 RE35710 RE36146 RE37736 RE37980 RE40250 RE40342 RE43147 RE44818 RE48193 RE50193 RE50316 RE55869 RE62517 RE65983 RE66113 RE66210 RE70731
Other clones	264 8116 15854 18144 30581 38111 38120 38148 38790 44322 52600 54898 57942 63123 75381 77649 78701 79530 79867 80638 101608 108572 145414 146635 147723 160801 161624 163080 192177 194317 214283.16 214411.18 214449.67 214533.20 275126 CK01.9D.C6 CK01.18C.D10 CK01.25B.E8 CK01.29C.C1 CK01.54D.D4 CK01.58D.H10 CK01.69A.H8 CK01.74C.H4 CK01.93B.A10 CK01.96D.C12 CK01.107A.D9 CK01.109B.D11 CK01.126D.F6 Dmel_dig_000672_0718_0313 Dmel_dig_000718_0706_3708 Dmel_dig_015556_0652_3297 Dmel_neb_000863_0348_3738 EC34674 EC053797 EK022552 EK030104 EK043512 EK044446 EK047663 EK054702 EK055264 EK058562 EK071709 EK073525 EK075044 EK089413 EK097155 EK098716 EK106413 EK107024 EK126247 EK131351 EK139459 EK143403 EK150635 EK150847 EK151602 EK159456 EK161204 EK168517 EK181423 EK189053 EK205328 EK206362 EK209354 EK212551 EK213736 EK228545 EK235134 EK249248 EK252848 EK267442 EK294821 EK303328 EP01310 EP02346 EP13818 EP18712
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025574 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42821
Antibody Information
	polyclonal (Grosshans et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Pli CG5212 (Kodira, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Identification: Two hybrid yeast screen with pll protein as a binding partner. (Grosshans et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079742 NM_001104420 RefSeq (Proteins) • NP_524466 NP_001097890 DDBJ / EMBL / GenBank • AAC96298 AAF56198 AAL39777 ABW08739 ABW08740 AF091624 AI514334 AY069632 BH615025 CZ467310 CZ481423 CZ482952 Entrez Gene - A searchable database of RefSeq genes. • 42821 UniProtKB/Swiss-Prot • O77237 UniProtKB/TrEMBL • A8JR89
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Pellino family (IPR006800) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM07040
Linkouts
	BioGRID - A database of protein and genetic interactions • 67757 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025574 DroID - A comprehensive database of gene and protein interactions. • FBgn0025574 DRSC - Results from RNAi screens. • FBgn0025574 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025574 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5212-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025574 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42821 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42821 modMine - Data generated by the modENCODE project. • FBgn0025574
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG5212 (Ni et al., 2011.7.19, Keleman et al., 2009.8.5) PAP   Pli (Buszczak et al., 2007, Akdemir et al., 2007, Haghayeghi et al., 2010, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Pelle associated protein   pellino (Schneider, 2000, Lemaitre, 2000.12.20) Pellino (Zhou et al., 2008, Singer and Gall, 2011, Haghayeghi et al., 2010)
Secondary FlyBase IDs
References ( 37 )
Generate a list of	All references relating to this gene ( 37 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 5 ) Review  ( 3 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Curated genome annotation  ( 1 ) DNA/RNA sequence record  ( 1 ) Thesis  ( 1 )
Recent research papers ( 1 )
	Singer and Gall, 2011, Nucleus 2(5): 403--409 An inducible nuclear body in the Drosophila germinal vesicle. [FBrf0216533] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...