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Gene Dmel\Int6

General Information
Symbol	Dmel\Int6	Species	D. melanogaster
Name	Int6 homologue	Annotation symbol	CG9677
Feature type	protein_coding_gene	FlyBase ID	FBgn0025582
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	l(3)10547, eIF3-S6
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	73C4-73C4	Sequence location	3L:16,778,342..16,780,089 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Int6 homologue is referred to in FlyBase by the symbol Dmel\Int6 (CG9677, FBgn0025582). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation initiation factor activity. There is experimental evidence that it is involved in the biological process: phagocytosis, engulfment. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Eukaryotic translation initiation factor 3 (eIF3), subunit 6, N-terminal; Proteasome component (PCI) domain; Translation initiation factor 3, subunit 6, eukaryotic; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1640174_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Int6. Gene sequence location is 3L:16778342..16780089.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Alleles Int6[A69] Sequence features BKN21219 HFA11199 References Andersen et al., 2010, Mol. Cell. Biol. 30(19): 4744--4755
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 73C4-73C4   Limits computationally determined from genome sequence between P{PZ}Baldspot02281 and P{PZ}blot01658
Experimentally Determined Cytological Location
Cytogenetic map Notes References 73D1-73D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 73C2-73C2   (determined by in situ hybridisation)   (Miyazaki et al., 1999) 73D1-73D2   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Int6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Int6-RA FBtr0075345  NM_058037   1568   435
Additional Transcript Data & Comments
Reported size (kB)	1.5 (northern blot) (Miyazaki et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Int6-PA   FBpp0075104   51.2   435   6.77     NP_477385   AAF49412
Additional Polypeptide Data & Comments
Reported size (kDa)	435 (aa); 48 (kD observed) (Miyazaki et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Proteasome component (PCI) domain (IPR000717) Translation initiation factor 3, subunit 6, eukaryotic (IPR016650) Eukaryotic translation initiation factor 3 (eIF3), subunit 6, N-terminal (IPR019010) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246580   AA263372   AA264092   AA264637   AA391772   AA392958   AA438397   AA439358   AA439799   AA441114   AA539536   AA540215   AA694676   AA694852   AA696155   AA696680   AA735523   AA802745   AA803116   AE014296 AAF49412   AC006933   AF132551 AAD27850   AI108293   AI134313   AI238874   AI515427   AI517565   AI520570   AI541642   AQ073349   AW941124   AY122062   AY231747   AY440471   BF486882   BF498625   BF504242   BG638068   BG640626   BI170939   BI215506   BI232073   BI234803   BI235833   BI357498   BI364308   BI365626   BI372692   BI372773   BI484575   BI567013   BI567108   BI579421   BI579573   BI586242   BI589431   BI605621   BP546128   BP546153   BP547311   BP552521   BX023435   BX027569   BX029578   BX036704   BX057833   CK132502   CO189358   CO195788   CO280559   CO284916   CO297702   CO300934   CO304523   CO310158   CO318981   CO337599   DQ440308   EC057851   EC073329   EC077015   EC085876   EC216386   EC234446   EC234606   EC236526   EC237323   EL873867   ES694718   ES694739   ES695283   EV585830   EV586759   EV588190   EV592029   EV596033   EV596217   EV599680   EV600431   EV600532   FF579441   FF579560   U89162 AAC62307
UniProtKB/Swiss-Prot	O77410
UniProtKB/TrEMBL	Q8MR88
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Miyazaki et al., 1999)
Additional Descriptive Data
	Int6 transcripts are detected at all developmental stages tested. Levels are particularly high in early embryos. (Miyazaki et al., 1999)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Miyazaki et al., 1999)
Additional Descriptive Data
	Int6 protein is detected at all developmental stages tested. Levels are particularly high in early embryos. (Miyazaki et al., 1999)
Marker for
Subcellular Localization
CV Term	microsome (Miyazaki et al., 1999)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0025582    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0025582 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0025582 expression level Developmental Stage   Expression Level embryo 00-02hr    18003 embryo 02-04hr    27463 embryo 04-06hr    31365 embryo 06-08hr    24319 embryo 08-10hr    28188 embryo 10-12hr    28159 embryo 12-14hr    16614 embryo 14-16hr    16000 embryo 16-18hr    12718 embryo 18-20hr    11273 embryo 20-22hr    12004 embryo 22-24hr    12014 larva L1    17275 larva L2    16025 larva L3 12hr old    11875 larva L3 puffstage 1-2    9703 larva L3 puffstage 3-6    9890 larva L3 puffstage 7-9    11502 white prepupae new    11294 white prepupae 12hr    11105 white prepupae 24hr    11505 pupae 2d postWPP    8327 pupae 3d postWPP    6222 pupae 4d postWPP    6860 adult male 01day    7085 adult male 05day    7681 adult male 30day    7303 adult female 01day    14539 adult female 05day    15709 adult female 30day    15978 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (18003) embryo 02-04hr  (27463) embryo 04-06hr  (31365) embryo 06-08hr  (24319) embryo 08-10hr  (28188) embryo 10-12hr  (28159) embryo 12-14hr  (16614) embryo 14-16hr  (16000) embryo 16-18hr  (12718) embryo 18-20hr  (11273) embryo 20-22hr  (12004) embryo 22-24hr  (12014) larva L1  (17275) larva L2  (16025) larva L3 12hr old  (11875) larva L3 puffstage 1-2  (9703) larva L3 puffstage 3-6  (9890) larva L3 puffstage 7-9  (11502) white prepupae new  (11294) white prepupae 12hr  (11105) white prepupae 24hr  (11505) pupae 2d postWPP  (8327) pupae 3d postWPP  (6222) pupae 4d postWPP  (6860) adult male 01day  (7085) adult male 05day  (7681) adult male 30day  (7303) adult female 01day  (14539) adult female 05day  (15709) adult female 30day  (15978) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (18003) embryo 02-04hr  (27463) embryo 04-06hr  (31365) embryo 06-08hr  (24319) embryo 08-10hr  (28188) embryo 10-12hr  (28159) embryo 12-14hr  (16614) embryo 14-16hr  (16000) embryo 16-18hr  (12718) embryo 18-20hr  (11273) embryo 20-22hr  (12004) embryo 22-24hr  (12014) larva L1  (17275) larva L2  (16025) larva L3 12hr old  (11875) larva L3 puffstage 1-2  (9703) larva L3 puffstage 3-6  (9890) larva L3 puffstage 7-9  (11502) white prepupae new  (11294) white prepupae 12hr  (11105) white prepupae 24hr  (11505) pupae 2d postWPP  (8327) pupae 3d postWPP  (6222) pupae 4d postWPP  (6860) adult male 01day  (7085) adult male 05day  (7681) adult male 30day  (7303) adult female 01day  (14539) adult female 05day  (15709) adult female 30day  (15978) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (18003) embryo 02-04hr  (27463) embryo 04-06hr  (31365) embryo 06-08hr  (24319) embryo 08-10hr  (28188) embryo 10-12hr  (28159) embryo 12-14hr  (16614) embryo 14-16hr  (16000) embryo 16-18hr  (12718) embryo 18-20hr  (11273) embryo 20-22hr  (12004) embryo 22-24hr  (12014) larva L1  (17275) larva L2  (16025) larva L3 12hr old  (11875) larva L3 puffstage 1-2    9703 larva L3 puffstage 3-6    9890 larva L3 puffstage 7-9  (11502) white prepupae new  (11294) white prepupae 12hr  (11105) white prepupae 24hr  (11505) pupae 2d postWPP    8327 pupae 3d postWPP    6222 pupae 4d postWPP    6860 adult male 01day    7085 adult male 05day    7681 adult male 30day    7303 adult female 01day  (14539) adult female 05day  (15709) adult female 30day  (15978) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18003 embryo 02-04hr    27463 embryo 04-06hr    31365 embryo 06-08hr    24319 embryo 08-10hr    28188 embryo 10-12hr    28159 embryo 12-14hr    16614 embryo 14-16hr    16000 embryo 16-18hr    12718 embryo 18-20hr    11273 embryo 20-22hr    12004 embryo 22-24hr    12014 larva L1    17275 larva L2    16025 larva L3 12hr old    11875 larva L3 puffstage 1-2    9703 larva L3 puffstage 3-6    9890 larva L3 puffstage 7-9    11502 white prepupae new    11294 white prepupae 12hr    11105 white prepupae 24hr    11505 pupae 2d postWPP    8327 pupae 3d postWPP    6222 pupae 4d postWPP    6860 adult male 01day    7085 adult male 05day    7681 adult male 30day    7303 adult female 01day    14539 adult female 05day    15709 adult female 30day    15978 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0025582 expression level Developmental Stage   Expression Level embryo 00-02hr    18003 embryo 02-04hr    27463 embryo 04-06hr    31365 embryo 06-08hr    24319 embryo 08-10hr    28188 embryo 10-12hr    28159 embryo 12-14hr    16614 embryo 14-16hr    16000 embryo 16-18hr    12718 embryo 18-20hr    11273 embryo 20-22hr    12004 embryo 22-24hr    12014 larva L1    17275 larva L2    16025 larva L3 12hr old    11875 larva L3 puffstage 1-2    9703 larva L3 puffstage 3-6    9890 larva L3 puffstage 7-9    11502 white prepupae new    11294 white prepupae 12hr    11105 white prepupae 24hr    11505 pupae 2d postWPP    8327 pupae 3d postWPP    6222 pupae 4d postWPP    6860 adult male 01day    7085 adult male 05day    7681 adult male 30day    7303 adult female 01day    14539 adult female 05day    15709 adult female 30day    15978 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (18003) embryo 02-04hr  (27463) embryo 04-06hr  (31365) embryo 06-08hr  (24319) embryo 08-10hr  (28188) embryo 10-12hr  (28159) embryo 12-14hr  (16614) embryo 14-16hr  (16000) embryo 16-18hr  (12718) embryo 18-20hr  (11273) embryo 20-22hr  (12004) embryo 22-24hr  (12014) larva L1  (17275) larva L2  (16025) larva L3 12hr old  (11875) larva L3 puffstage 1-2  (9703) larva L3 puffstage 3-6  (9890) larva L3 puffstage 7-9  (11502) white prepupae new  (11294) white prepupae 12hr  (11105) white prepupae 24hr  (11505) pupae 2d postWPP  (8327) pupae 3d postWPP  (6222) pupae 4d postWPP  (6860) adult male 01day  (7085) adult male 05day  (7681) adult male 30day  (7303) adult female 01day  (14539) adult female 05day  (15709) adult female 30day  (15978) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (18003) embryo 02-04hr  (27463) embryo 04-06hr  (31365) embryo 06-08hr  (24319) embryo 08-10hr  (28188) embryo 10-12hr  (28159) embryo 12-14hr  (16614) embryo 14-16hr  (16000) embryo 16-18hr  (12718) embryo 18-20hr  (11273) embryo 20-22hr  (12004) embryo 22-24hr  (12014) larva L1  (17275) larva L2  (16025) larva L3 12hr old  (11875) larva L3 puffstage 1-2  (9703) larva L3 puffstage 3-6  (9890) larva L3 puffstage 7-9  (11502) white prepupae new  (11294) white prepupae 12hr  (11105) white prepupae 24hr  (11505) pupae 2d postWPP  (8327) pupae 3d postWPP  (6222) pupae 4d postWPP  (6860) adult male 01day  (7085) adult male 05day  (7681) adult male 30day  (7303) adult female 01day  (14539) adult female 05day  (15709) adult female 30day  (15978) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  18003 embryo 02-04hr  (27463) embryo 04-06hr  (31365) embryo 06-08hr  (24319) embryo 08-10hr  (28188) embryo 10-12hr  (28159) embryo 12-14hr  16614 embryo 14-16hr  16000 embryo 16-18hr  12718 embryo 18-20hr  11273 embryo 20-22hr  12004 embryo 22-24hr  12014 larva L1  17275 larva L2  16025 larva L3 12hr old  11875 larva L3 puffstage 1-2    9703 larva L3 puffstage 3-6    9890 larva L3 puffstage 7-9  11502 white prepupae new  11294 white prepupae 12hr  11105 white prepupae 24hr  11505 pupae 2d postWPP    8327 pupae 3d postWPP    6222 pupae 4d postWPP    6860 adult male 01day    7085 adult male 05day    7681 adult male 30day    7303 adult female 01day  14539 adult female 05day  15709 adult female 30day  15978 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18003 embryo 02-04hr    27463 embryo 04-06hr    31365 embryo 06-08hr    24319 embryo 08-10hr    28188 embryo 10-12hr    28159 embryo 12-14hr    16614 embryo 14-16hr    16000 embryo 16-18hr    12718 embryo 18-20hr    11273 embryo 20-22hr    12004 embryo 22-24hr    12014 larva L1    17275 larva L2    16025 larva L3 12hr old    11875 larva L3 puffstage 1-2    9703 larva L3 puffstage 3-6    9890 larva L3 puffstage 7-9    11502 white prepupae new    11294 white prepupae 12hr    11105 white prepupae 24hr    11505 pupae 2d postWPP    8327 pupae 3d postWPP    6222 pupae 4d postWPP    6860 adult male 01day    7085 adult male 05day    7681 adult male 30day    7303 adult female 01day    14539 adult female 05day    15709 adult female 30day    15978 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0025582    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0025582 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0025582 expression level Tissue   Expression Level Larval Central Nervous System    1093.525 Larval Midgut    718.8 Larval Hindgut    1002.3 Larval Malpighian Tubules    907.6 Larval Fat Body    859.1 Larval Salivary Gland    1948.7 Larval Trachea    1687.3 Larval Carcass    1269.4 Adult Head    825.9 Adult Eye    1333.45 Adult Brain    554 Adult Thoracic-Abdominal Ganglion    732.6 Adult Crop    950.1 Adult Midgut    926.6 Adult Hindgut    920.4 Adult Malpighian Tubules    948 Adult Fat Body    1293.3 Adult Salivary Gland    1452.8 Adult Heart    1207.9 Adult VirginFemale Spermatheca    1485.8 Adult InseminatedFemale Spermatheca    1588 Adult Ovary    1012.6 Adult Testis    399.6 Adult Male Accessory Gland    2203.8 Adult Carcass    806.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1093.525) Larval Midgut  (718.8) Larval Hindgut  (1002.3) Larval Malpighian Tubules  (907.6) Larval Fat Body  (859.1) Larval Salivary Gland  (1948.7) Larval Trachea  (1687.3) Larval Carcass  (1269.4) Adult Head  (825.9) Adult Eye  (1333.45) Adult Brain  (554) Adult Thoracic-Abdominal Ganglion  (732.6) Adult Crop  (950.1) Adult Midgut  (926.6) Adult Hindgut  (920.4) Adult Malpighian Tubules  (948) Adult Fat Body  (1293.3) Adult Salivary Gland  (1452.8) Adult Heart  (1207.9) Adult VirginFemale Spermatheca  (1485.8) Adult InseminatedFemale Spermatheca  (1588) Adult Ovary  (1012.6) Adult Testis    399.6 Adult Male Accessory Gland  (2203.8) Adult Carcass  (806.6) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1093.525) Larval Midgut    718.8 Larval Hindgut  1002.3 Larval Malpighian Tubules    907.6 Larval Fat Body    859.1 Larval Salivary Gland  (1948.7) Larval Trachea  (1687.3) Larval Carcass  (1269.4) Adult Head    825.9 Adult Eye  (1333.45) Adult Brain    554 Adult Thoracic-Abdominal Ganglion    732.6 Adult Crop    950.1 Adult Midgut    926.6 Adult Hindgut    920.4 Adult Malpighian Tubules    948 Adult Fat Body  (1293.3) Adult Salivary Gland  (1452.8) Adult Heart  (1207.9) Adult VirginFemale Spermatheca  (1485.8) Adult InseminatedFemale Spermatheca  (1588) Adult Ovary  1012.6 Adult Testis    399.6 Adult Male Accessory Gland  (2203.8) Adult Carcass    806.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1093.525 Larval Midgut    718.8 Larval Hindgut    1002.3 Larval Malpighian Tubules    907.6 Larval Fat Body    859.1 Larval Salivary Gland    1948.7 Larval Trachea    1687.3 Larval Carcass    1269.4 Adult Head    825.9 Adult Eye    1333.45 Adult Brain    554 Adult Thoracic-Abdominal Ganglion    732.6 Adult Crop    950.1 Adult Midgut    926.6 Adult Hindgut    920.4 Adult Malpighian Tubules    948 Adult Fat Body    1293.3 Adult Salivary Gland    1452.8 Adult Heart    1207.9 Adult VirginFemale Spermatheca    1485.8 Adult InseminatedFemale Spermatheca    1588 Adult Ovary    1012.6 Adult Testis    399.6 Adult Male Accessory Gland    2203.8 Adult Carcass    806.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0025582 expression level Tissue   Expression Level Larval Central Nervous System    1093.525 Larval Midgut    718.8 Larval Hindgut    1002.3 Larval Malpighian Tubules    907.6 Larval Fat Body    859.1 Larval Salivary Gland    1948.7 Larval Trachea    1687.3 Larval Carcass    1269.4 Adult Head    825.9 Adult Eye    1333.45 Adult Brain    554 Adult Thoracic-Abdominal Ganglion    732.6 Adult Crop    950.1 Adult Midgut    926.6 Adult Hindgut    920.4 Adult Malpighian Tubules    948 Adult Fat Body    1293.3 Adult Salivary Gland    1452.8 Adult Heart    1207.9 Adult VirginFemale Spermatheca    1485.8 Adult InseminatedFemale Spermatheca    1588 Adult Ovary    1012.6 Adult Testis    399.6 Adult Male Accessory Gland    2203.8 Adult Carcass    806.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1093.525) Larval Midgut  718.8 Larval Hindgut  (1002.3) Larval Malpighian Tubules  (907.6) Larval Fat Body  (859.1) Larval Salivary Gland  (1948.7) Larval Trachea  (1687.3) Larval Carcass  (1269.4) Adult Head  (825.9) Adult Eye  (1333.45) Adult Brain  554 Adult Thoracic-Abdominal Ganglion  732.6 Adult Crop  (950.1) Adult Midgut  (926.6) Adult Hindgut  (920.4) Adult Malpighian Tubules  (948) Adult Fat Body  (1293.3) Adult Salivary Gland  (1452.8) Adult Heart  (1207.9) Adult VirginFemale Spermatheca  (1485.8) Adult InseminatedFemale Spermatheca  (1588) Adult Ovary  (1012.6) Adult Testis    399.6 Adult Male Accessory Gland  (2203.8) Adult Carcass  806.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1093.525 Larval Midgut    718.8 Larval Hindgut  1002.3 Larval Malpighian Tubules    907.6 Larval Fat Body    859.1 Larval Salivary Gland  (1948.7) Larval Trachea  1687.3 Larval Carcass  1269.4 Adult Head    825.9 Adult Eye  1333.45 Adult Brain    554 Adult Thoracic-Abdominal Ganglion    732.6 Adult Crop    950.1 Adult Midgut    926.6 Adult Hindgut    920.4 Adult Malpighian Tubules    948 Adult Fat Body  1293.3 Adult Salivary Gland  1452.8 Adult Heart  1207.9 Adult VirginFemale Spermatheca  1485.8 Adult InseminatedFemale Spermatheca  1588 Adult Ovary  1012.6 Adult Testis    399.6 Adult Male Accessory Gland  (2203.8) Adult Carcass    806.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1093.525 Larval Midgut    718.8 Larval Hindgut    1002.3 Larval Malpighian Tubules    907.6 Larval Fat Body    859.1 Larval Salivary Gland    1948.7 Larval Trachea    1687.3 Larval Carcass    1269.4 Adult Head    825.9 Adult Eye    1333.45 Adult Brain    554 Adult Thoracic-Abdominal Ganglion    732.6 Adult Crop    950.1 Adult Midgut    926.6 Adult Hindgut    920.4 Adult Malpighian Tubules    948 Adult Fat Body    1293.3 Adult Salivary Gland    1452.8 Adult Heart    1207.9 Adult VirginFemale Spermatheca    1485.8 Adult InseminatedFemale Spermatheca    1588 Adult Ovary    1012.6 Adult Testis    399.6 Adult Male Accessory Gland    2203.8 Adult Carcass    806.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    825.9   NA  Eye    1333.45   NA  Brain    554   1093.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    732.6   NA  Crop    950.1   718.8  Midgut    926.6   1002.3  Hindgut    920.4   907.6  Malpighian Tubules    948   859.1  Fat Body    1293.3   1948.7  Salivary Gland    1452.8   NA  Heart    1207.9   1687.3  Trachea    NA   NA  VirginFemale Spermatheca    1485.8   NA  InseminatedFemale Spermatheca    1588   NA  Ovary    1012.6   NA  Testis    399.6   NA  Male Accessory Gland    2203.8   1269.4  Carcass    806.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025582 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9677-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Int6 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | first instar larval stage | recessive Int6173-1 Int610547 lethal | pupal stage, with Scer\GAL4pnr-MD237 Int6GD14286 lethal | recessive Int610547 Int6A69 Int6j9E8 Other Phenotypes Allele decreased cell number | somatic clone | third instar larval stage Int6A69 developmental rate defective | first instar larval stage | recessive Int6173-1 Int610547 Phenotype manifest in Allele embryonic/larval brain | somatic clone | third instar larval stage Int6A69 eye disc | somatic clone Int610547 female germline cell | germline clone Int610547 wing disc | somatic clone Int610547
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Int6 Class Mutagen Stocks Known lesion Int610547 P-element activity 0 Yes Int6173-1 Delta2-3 0 Yes Int6A69 ethyl methanesulfonate 0 -- Int6j9E8 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Int6 Class Mutagen Stocks Known lesion Int6GD14286 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Int6KK101123 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)81k19 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Cunniff et al., 1997) Df(3L)Exel6130 (Ryder, 2004.4.26) Df(3L)st-b11 (Cunniff et al., 1997) In(3L)std11 (Cunniff et al., 1997)
Not disrupted in	Df(3L)st4 (Cunniff et al., 1997) Df(3L)st100.62 (Cunniff et al., 1997) Df(3L)st-g24 (Cunniff et al., 1997) Df(3L)st-j7 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Cunniff et al., 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14286} NA P{KK101123} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Int6j9E8 No P{PZ}Int610547 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component
CV term Evidence References
microsome inferred from direct assay (Miyazaki et al., 1999)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
translation initiation factor activity inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with EMBL:AL035216 (FlyBase, 1992-) inferred from sequence or structural similarity with human EIF3E (Miyazaki et al., 1999) non-traceable author statement (Swiss-Prot Project Members, 1999.12.15)
Biological Process
CV term Evidence References
translational initiation inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with EMBL:AL035216 (FlyBase, 1992-) inferred from sequence or structural similarity with human EIF3E (Miyazaki et al., 1999)
Cellular Component
CV term Evidence References
cytosol non-traceable author statement (Swiss-Prot Project Members, 1999.12.15) eukaryotic translation initiation factor 3 complex inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with EMBL:AL035216 (FlyBase, 1992-) inferred from sequence or structural similarity with human EIF3E (Miyazaki et al., 1999) non-traceable author statement (Swiss-Prot Project Members, 1999.12.15)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Int6 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65176 DroID - A comprehensive database of gene and protein interactions. • FBgn0025582 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39877
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10503 Dere\GG15850 Dgri\GH15221 Dmoj\GI11931 Dper\GL16190 Dpse\GA21959 Dsec\GM24367 Dsim\GD12442 Dvir\GJ12157 Dwil\GK12672 Dyak\Int6
Curated drosophilid orthologs	Dmir\CG9677-like   Dpse\GA21959   Dsim\Int6 (Swanson et al., 2001) Dyak\Int6
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002334-PA Aedes aegypti (mosquito) AGAP006944-PA Anopheles gambiae (mosquito) XP_623637.2 Apis mellifera (honey bee) XP_001949492.1 Acyrthosiphon pisum (pea aphid) XP_001952525.1 Acyrthosiphon pisum (pea aphid) At3g57290.1 Arabidopsis thaliana (wall cress) 20238 Batrachochytrium dendrobatidis (chytrid fungus) 114473 Branchiostoma floridae (lancelet) XP_001893867.1 Brugia malayi (roundworm nematode) BGIBMGA003669-PA Bombyx mori (silk worm) ENSBTAP00000008809 Bos taurus (bovine) CBP35181 Caenorhabditis briggsae (nematode) CE17349 Caenorhabditis elegans (worm) ENSCAFP00000001005 Canis familiaris (dog) ENSCINP00000000189 Ciona intestinalis (sea squirt) JA08930 Caenorhabditis japonica (nematode) CMS102C Cyanidioschyzon merolae (red alga) cn13062 Cryptococcus neoformans (yeast-like fungus) cgd2_1500 Cryptosporidium parvum (protozoan parasite) CPIJ003936 Culex pipens (mosquito) ENSCPOP00000005649 Cavia porcellus (guinea pig) 132936 Chlamidomonas reinhardtii (green alga) RP29877 Caenorhabditis remanei (nematode) ENSCSAVP00000010486 Ciona savignyi (sedentary tunicate) 159549 Capitella spl (polychaete worm) DDB0233925 Dictyostelium discoideum (amoeba) 302804 Daphnia pulex (daphnia) ENSDARP00000003276 Danio rerio (zebra fish) ENSGACP00000007134 Gymnopilus aculeatus (mushroom) ENSGALP00000025883 Gallus gallus (chicken) 74899 Hypsipyla robusta (cedar shoot borer) ENSP00000220849 Homo sapiens (human) ISCW023004-PA Ixodes scapularis (deer tick) 126234 Lottia gigantea (owl limpet) LmjF28.2310 Leishmania major (virus) 13685 Monocosta brevicollis (choanoflagellate) ENSMODP00000006450 Monodelphis domestica (gray opossum) ENSMMUP00000014906 Macaca mulatta (rhesus monkey) ENSMUSP00000022960 Mus musculus (house mouse) 163572 Nematostella vectensis (starlet anemone) XP_001600308.1 Nasonia vitripennis (wasp) ENSORLP00000025643 Oryzias latipes (japanese killifish) LOC_Os07g12110.1 Oryza sativa (asian rice) 23030 Ostreococcus tauri (green alga) PFE1405c Plasmodium falciparum (protozoal parasite) PHUM000953-PA Pediculus humanus (human body louse) 199296 Physcomitrella patens (moss) ENSPPYP00000021115 Pongo pygmaeus (orangutan) 54016 Phytophthora ramorum (sudden oak death pathogen) 143156 Phytophthora sojae (root rot pathogen) 576239 Populus trichocarpa (black cottonwood) ENSPTRP00000035067 Pan troglodytes (chimpanzee) PVX_079840 Plasmodium vivax (protozoal parasite) ENSRNOP00000029790 Rattus norvegicus (norway rat) 4746986 Sorghum bicolor (sorghum) Smp_176230.1 Schistosoma mansoni (trematode parasite) SPBC646.09c Schizosaccharomyces pombe (fission yeast) XP_001193661.1 Strongylocentrotus purpuratus (purple sea urchin) 50473 Trichoplax adhaerens (metazoa) TA12845 Theileria annulata (apicomplexan parasite) XP_969967.1 Tribolium castaneum (red flour beetle) Tc00.1047053508699.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509205.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000006863 Tetraodon nigroviridis (green spotted pufferfish) TP02_0376 Theileria parva (parasitic protozoan) 27083 Thalassiosira pseudonana (marine diatom) ENSTRUP00000012150 Takifugu rubripes (pufferfish Takifugu) 3685.m00662 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000007769 Xenopus tropicalis (frog) YALI0F22671g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15381 NV17317 LH22413 ISCW023004 FBgn0068137 FBgn0225331 FBgn0224099 FBgn0214681 FBgn0199409 FBgn0184174 FBgn0179231 JGI_V11_302804 FBgn0081944 FBgn0153794 FBgn0134689 FBgn0122696 FBgn0108088 FBgn0087544 CPIJ003936 BGIBMGA003669 ACYPI004684 ACYPI002661 GB19077 EIF3E_ANOGA AAEL002334 PHUM042220 GLEAN_02738
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v103559 P{KK101123}VIE-260B v27032 w1118; P{GD14286}v27032
Genomic Clones ( 2 )
	BACR11G05 BACR48E21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 86 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT01736 GM01233
Other clones	yak-em_Int6
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05561 AT13066 AT21453 GH07102 GH11742 GH15006 GH28571 GM01673 GM05189 GM06247 GM07052 GM08129 LD05340 LD06201 LD07794 LD08234 LD11529 LD12155 LD12670 LD13907 LD16007 LD17715 LD19627 LD21455 LD40765 LD47254 LP14069 RE12571 RE22022 RE28080 RE30560 RE31775 RE44008 RE49391 RE50989 RE59733 RE59933 RE67701 RE73448 RE73630 RH26104 RH33868 RH36840 RH36961 RH71453 SD05691 SD11752
Other clones	40538 54660 57034 60945 97801 108587 120458 193804 CK01.54A.D8 Dmel_dig_006022_0659_3629 Dmel_neb_004109_0897_2131 Dmel_neb_010301_0945_1452 Dmel_neb_013312_0131_1450 Dmel_neb_013682_0102_2061 Dmel_neb_013956_0638_2060 Dmel_neb_014043_0576_1337 Dmel_neb_014844_0949_1343 Dmel_neb_015479_0619_2334 EC40968 EK044048 EK154339 EK167456 EK170354 EK179721 EK220621 EK245013 EK275702 Elena_26_G08 EN14903 FGH103B05 FGH103D06 FGH115F05 FGM219C03 IP13952 LD14464 Parral_28_B07
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025582 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39877
Antibody Information
	polyclonal (Miyazaki et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Int6 l(3)10547 (Spradling et al., 1999)
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058037 RefSeq (Proteins) • NP_477385 DDBJ / EMBL / GenBank • AA439358 AA694676 AAC62307 AAD27850 AAF49412 AC006933 AF132551 AQ073349 AW941124 U89162 Entrez Gene - A searchable database of RefSeq genes. • 39877 UniProtKB/Swiss-Prot • O77410 UniProtKB/TrEMBL • Q8MR88
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Proteasome component (PCI) domain (IPR000717) Translation initiation factor 3, subunit 6, eukaryotic (IPR016650) Eukaryotic translation initiation factor 3 (eIF3), subunit 6, N-terminal (IPR019010) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65176 DroID - A comprehensive database of gene and protein interactions. • FBgn0025582 DRSC - Results from RNAi screens. • FBgn0025582 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025582 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9677-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025582 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39877 InParanoid A subset of ortholog calls from InParanoid. • AAEL002334-PA Aedes aegypti (mosquito) AGAP006944-PA Anopheles gambiae (mosquito) XP_623637.2 Apis mellifera (honey bee) XP_001949492.1 Acyrthosiphon pisum (pea aphid) XP_001952525.1 Acyrthosiphon pisum (pea aphid) At3g57290.1 Arabidopsis thaliana (wall cress) 20238 Batrachochytrium dendrobatidis (chytrid fungus) 114473 Branchiostoma floridae (lancelet) XP_001893867.1 Brugia malayi (roundworm nematode) BGIBMGA003669-PA Bombyx mori (silk worm) ENSBTAP00000008809 Bos taurus (bovine) CBP35181 Caenorhabditis briggsae (nematode) CE17349 Caenorhabditis elegans (worm) ENSCAFP00000001005 Canis familiaris (dog) ENSCINP00000000189 Ciona intestinalis (sea squirt) JA08930 Caenorhabditis japonica (nematode) CMS102C Cyanidioschyzon merolae (red alga) cn13062 Cryptococcus neoformans (yeast-like fungus) cgd2_1500 Cryptosporidium parvum (protozoan parasite) CPIJ003936 Culex pipens (mosquito) ENSCPOP00000005649 Cavia porcellus (guinea pig) 132936 Chlamidomonas reinhardtii (green alga) RP29877 Caenorhabditis remanei (nematode) ENSCSAVP00000010486 Ciona savignyi (sedentary tunicate) 159549 Capitella spl (polychaete worm) DDB0233925 Dictyostelium discoideum (amoeba) 302804 Daphnia pulex (daphnia) ENSDARP00000003276 Danio rerio (zebra fish) ENSGACP00000007134 Gymnopilus aculeatus (mushroom) ENSGALP00000025883 Gallus gallus (chicken) 74899 Hypsipyla robusta (cedar shoot borer) ENSP00000220849 Homo sapiens (human) ISCW023004-PA Ixodes scapularis (deer tick) 126234 Lottia gigantea (owl limpet) LmjF28.2310 Leishmania major (virus) 13685 Monocosta brevicollis (choanoflagellate) ENSMODP00000006450 Monodelphis domestica (gray opossum) ENSMMUP00000014906 Macaca mulatta (rhesus monkey) ENSMUSP00000022960 Mus musculus (house mouse) 163572 Nematostella vectensis (starlet anemone) XP_001600308.1 Nasonia vitripennis (wasp) ENSORLP00000025643 Oryzias latipes (japanese killifish) LOC_Os07g12110.1 Oryza sativa (asian rice) 23030 Ostreococcus tauri (green alga) PFE1405c Plasmodium falciparum (protozoal parasite) PHUM000953-PA Pediculus humanus (human body louse) 199296 Physcomitrella patens (moss) ENSPPYP00000021115 Pongo pygmaeus (orangutan) 54016 Phytophthora ramorum (sudden oak death pathogen) 143156 Phytophthora sojae (root rot pathogen) 576239 Populus trichocarpa (black cottonwood) ENSPTRP00000035067 Pan troglodytes (chimpanzee) PVX_079840 Plasmodium vivax (protozoal parasite) ENSRNOP00000029790 Rattus norvegicus (norway rat) 4746986 Sorghum bicolor (sorghum) Smp_176230.1 Schistosoma mansoni (trematode parasite) SPBC646.09c Schizosaccharomyces pombe (fission yeast) XP_001193661.1 Strongylocentrotus purpuratus (purple sea urchin) 50473 Trichoplax adhaerens (metazoa) TA12845 Theileria annulata (apicomplexan parasite) XP_969967.1 Tribolium castaneum (red flour beetle) Tc00.1047053508699.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509205.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000006863 Tetraodon nigroviridis (green spotted pufferfish) TP02_0376 Theileria parva (parasitic protozoan) 27083 Thalassiosira pseudonana (marine diatom) ENSTRUP00000012150 Takifugu rubripes (pufferfish Takifugu) 3685.m00662 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000007769 Xenopus tropicalis (frog) YALI0F22671g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39877 modMine - Data generated by the modENCODE project. • FBgn0025582 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15381 NV17317 LH22413 ISCW023004 FBgn0068137 FBgn0225331 FBgn0224099 FBgn0214681 FBgn0199409 FBgn0184174 FBgn0179231 JGI_V11_302804 FBgn0081944 FBgn0153794 FBgn0134689 FBgn0122696 FBgn0108088 FBgn0087544 CPIJ003936 BGIBMGA003669 ACYPI004684 ACYPI002661 GB19077 EIF3E_ANOGA AAEL002334 PHUM042220 GLEAN_02738
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	BcDNA:GM01233   BcDNA.GM01233 (Tsang, 1999.3.2) CG9677 (Lasko, 2000, Keleman et al., 2009.8.5, Cammarato et al., 2011) DINT6 (Miyazaki et al., 1999) eIF3-p48/INT6 (Traicoff and Callahan, 2000) eIF-3p48/INT-6 (Miyazaki et al., 1999) eIF3-S6 (Lasko, 2000, Somma et al., 2008, Parry et al., 2010) Int6 (Stroschein-Stevenson et al., 2006, White et al., 2011, Sepp et al., 2008, Somma et al., 2008, Slack et al., 2006, Rencus-Lazar et al., 2008, Parry et al., 2010, Andersen et al., 2010) l(3)10547 (Beaton, 2000.1.31, Cunniff et al., 1997, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) l(3)j9E8
Name Synonym	Int6 homologue (Spradling et al., 1999, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0010945 FBgn0011424
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 2 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 4 )
	White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Andersen et al., 2010, Mol. Cell. Biol. 30(19): 4744--4755 Drosophila MCRS2 Associates with RNA Polymerase II Complexes To Regulate Transcription. [FBrf0211794] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Parry et al., 2010, Genes Dev. 24(18): 2013--2018 The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery. [FBrf0211834] Show all research papers ...