FB2019_05, released Oct 15, 2019

Gene: Dmel\eIF3e

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General Information
Symbol
Dmel\eIF3e
Species
D. melanogaster
Name
eukaryotic translation initiation factor 3 subunit e
Annotation Symbol
CG9677
Feature Type
protein_coding_gene
FlyBase ID
FBgn0025582
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Snapshot
eukaryotic translation initiation factor 3 subunit e (eIF3e) encodes a component of the translation initiation complex and is a positive regulator of cullin neddylation, which is required for Cullin-ring ubiquitin ligase activity. It also regulates spindle assembly, microtubule dynamics and mitotic progression. [Date last reviewed: 2018-10-18]
Other Summaries
Also Known As
Int6, l(3)10547, eIF3-S6, Int6 homologue
Key Links
Genomic Location
Cytogenetic map
73C4-73C4
Sequence location
3L:16,785,242..16,786,941 [-]
Recombination map
3-44
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the eIF-3 subunit E family. (O77410)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
translation initiation factor activity
Summaries
Gene Group (FlyBase)
CYTOPLASMIC TRANSLATION INITIATION FACTORS -
Cytoplasmic (or eukaryotic) translation initiation factors function in the initiation stage of ribosome-mediated translation in the cytoplasm. (Adapted from FBrf0233552 and PMID:20094052).
Protein Function (UniProtKB)
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (PubMed:18493598). In addition to its role in the eIF-3 complex, also functions in protein ubiquitination and degradation (PubMed:18493598, PubMed:28505193). During mitosis required for regulating mitotic microtubule growth and kinetochore formation, and consequently is required for satisfying the spindle assembly checkpoint (SAC) during metaphase to prevent delays in mitotic progression (PubMed:28505193). This is likely by promoting the ubiquitination and degradation of Klp67A, a kinesin-like protein that suppresses microtubule polymerization at plus ends (PubMed:28505193). Acts in the COP9 signalosome (CSN) mediated regulation of cullin neddylation by promoting Cul1 and Cul3 neddylation and negatively regulating the CSN complex subunit CSN5 (PubMed:18493598).
(UniProt, O77410)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\eIF3e or the JBrowse view of Dmel\eIF3e for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.46
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
eIF3e-RA
FBtr0075345
NM_058037
1520
435
Additional Transcript Data and Comments
Reported size (kB)
1.5 (northern blot)
(Miyazaki et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
eIF3e-PA
FBpp0075104
51.2
435
6.77
NP_477385
AAF49412
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
435 (aa); 48 (kD observed)
(Miyazaki et al., 1999)
Comments
External Data
Subunit Structure (UniProtKB)
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt (PubMed:23716590).
(UniProt, O77410)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eIF3e using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
translation initiation factor activity
inferred from sequence or structural similarity with HGNC:3277
(Miyazaki et al., 1999)
inferred from sequence or structural similarity
(Lasko, 2000)
inferred from biological aspect of ancestor with PANTHER:PTN000035120
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
translational initiation
inferred from sequence or structural similarity
(Lasko, 2000)
inferred from biological aspect of ancestor with PANTHER:PTN000035120
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:3277
(Miyazaki et al., 1999)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
intracellular membrane-bounded organelle
inferred from direct assay
(Miyazaki et al., 1999)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
eukaryotic translation initiation factor 3 complex
inferred from sequence or structural similarity
(Lasko, 2000)
inferred from sequence or structural similarity with HGNC:3277
(Miyazaki et al., 1999)
inferred from biological aspect of ancestor with PANTHER:PTN000035120
(assigned by GO_Central )
(Gaudet et al., 2011)
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000035120
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Miyazaki et al., 1999)
Additional Descriptive Data
Int6 transcripts are detected at all developmental stages tested. Levels are particularly high in early embryos.
(Miyazaki et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Miyazaki et al., 1999)
Additional Descriptive Data
Int6 protein is detected at all developmental stages tested. Levels are particularly high in early embryos.
(Miyazaki et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
intracellular membrane-bounded organelle
inferred from direct assay
(Miyazaki et al., 1999)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\eIF3e in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of eIF3e
Transgenic constructs containing regulatory region of eIF3e
Deletions and Duplications ( 10 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\EIF3E
14 of 15
Yes
Yes
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Eif3e
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Eif3el1
13 of 13
Yes
Yes
Rnor\LOC108348260
2 of 13
No
Yes
Rnor\Eif3e
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\eif3e
11 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\eif3eb
13 of 15
Yes
Yes
Drer\eif3ea
12 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\eif-3.E
12 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\EIF3E
9 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\int6
12 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091907ME )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\eIF3e
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010856
Drosophila simulans
Dsim\GD12442
Drosophila sechellia
Dsec\GM24367
Drosophila erecta
Dere\GG15850
Drosophila yakuba
Dyak\Int6
Drosophila ananassae
Dana\GF10503
Drosophila pseudoobscura pseudoobscura
Dpse\GA21959
Drosophila persimilis
Dper\GL16190
Drosophila willistoni
Dwil\GK22114
Drosophila willistoni
Dwil\GK12672
Drosophila virilis
Dvir\GJ12157
Drosophila mojavensis
Dmoj\GI11931
Drosophila grimshawi
Dgri\GH15221
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504G9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017556
Glossina morsitans
Tsetse fly
Gmor\GMOY009287
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07530
Mayetiola destructor
Hessian fly
Mdes\Mdes000108
Aedes aegypti
Yellow fever mosquito
Aaeg\eIF3-S6
Anopheles darlingi
American malaria mosquito
Adar\ADAC001582
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04CD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003669
Danaus plexippus
Monarch butterfly
Dple\DPOGS215609-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005811
Apis florea
Little honeybee
Aflo\3399506900
Apis mellifera
Western honey bee
Amel\GB53916
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25236
Bombus terrestris
Buff-tailed bumblebee
Bter\15205341
Linepithema humile
Argentine ant
Lhum\LH22413
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0020f9
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016846
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12325
Tribolium castaneum
Red flour beetle
Tcas\TC002738
Pediculus humanus
Human body louse
Phum\PHUM042220
Rhodnius prolixus
Kissing bug
Rpro\RPRC004935
Cimex lectularius
Bed bug
Clec\CLEC008497
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002661
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004684
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04124
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0491 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013786
Ixodes scapularis
Black-legged tick
Isca\ISCW023004
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67912.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur23g00430
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302804
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G075K )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Eif3e_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Eif3e
Ciona intestinalis
Vase tunicate
Cint\LOC100185058
Gallus gallus
Domestic chicken
Ggal\EIF3E
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    eIF3e10547
    ameliorates  autosomal dominant cerebellar ataxia
    modeled by Hsap\ATXN8OSCTG112.UAS
    (Mutsuddi et al., 2004)
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    EIF3E; eukaryotic translation initiation factor 3 subunit E
    14 of 15
    602210
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        eIF3e - Lkb1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        eIF3e - Pten
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        eIF3e - S6kII
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        eIF3e - eIF3a
        experimental knowledge based
        (Guruharsha et al., 2011)
        eIF3e - eIF3b
        experimental knowledge based
        (Guruharsha et al., 2011)
        eIF3e - eIF3c
        experimental knowledge based
        (Guruharsha et al., 2011)
        eIF3e - eIF3d1
        experimental knowledge based
        (Guruharsha et al., 2011)
        eIF3e - eIF3f1
        experimental knowledge based
        (Guruharsha et al., 2011)
        eIF3e - eIF3g1
        experimental knowledge based
        (Guruharsha et al., 2011)
        eIF3e - eIF3h
        experimental knowledge based
        (Guruharsha et al., 2011)
        eIF3e - eIF3k
        experimental knowledge based
        (Guruharsha et al., 2011)
        eIF3e - eIF3l
        experimental knowledge based
        (Guruharsha et al., 2011)
        eIF3e - eIF3m
        experimental knowledge based
        (Guruharsha et al., 2011)
        eIF3e - foxo
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        eIF3e - gig
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        eIF3e - mxt
        anti tag coimmunoprecipitation, anti tag western blot
        (Hernández et al., 2013)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Subunit Structure (UniProtKB)
        Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt (PubMed:23716590).
        (UniProt, O77410 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-44
        Cytogenetic map
        73C4-73C4
        Sequence location
        3L:16,785,242..16,786,941 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        73C4-73C4
        Limits computationally determined from genome sequence between P{PZ}Baldspot02281 and P{PZ}blot01658
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        73D1-73D2
        (determined by in situ hybridisation)
        (Spradling et al., 1999, BDGP Project Members, 1994-1999)
        73C2-73C2
        (determined by in situ hybridisation)
        (Miyazaki et al., 1999)
        Experimentally Determined Recombination Data
        Location
        3-44
        (FlyBase, 2016)
        3-39.4
        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (4)
        Genomic Clones (13)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (245)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          polyclonal
          (Renda et al., 2017, Miyazaki et al., 1999)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for identity of: eIF3e Int6
          (Marygold et al., 2017)
          Source for database merge of
          Source for merge of: Int6 l(3)10547
          (Spradling et al., 1999)
          Additional comments
          Other Comments
          S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
          (Stroschein-Stevenson et al., 2006)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 47 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          modMine - A data warehouse for the modENCODE project
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (13)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (63)