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Gene Dmel\IM2

General Information
Symbol	Dmel\IM2	Species	D. melanogaster
Name	Immune induced molecule 2	Annotation symbol	CG18106
Feature type	protein_coding_gene	FlyBase ID	FBgn0025583
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	DIM2
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	55C4-55C4	Sequence location	2R:14,274,102..14,274,535 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Immune induced molecule 2 is referred to in FlyBase by the symbol Dmel\IM2 (CG18106, FBgn0025583). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: defense response. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Immune-induced protein Dim. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, adult Malpighian tubules, larval fat body. Comments on Affy2 ProbeSet: ProbeSet 1640360_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of IM2. Gene sequence location is 2R:14274102..14274535.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN33219
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 55C4-55C4   Limits computationally determined from genome sequence between P{PZ}sbb04525&P{EP}EP1081EP1081 and P{lacW}l(2)08770k04808
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\IM2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Unclear source of 9aa mismatch in middle of CG18106 peptides and SWP O77150.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) IM2-RA FBtr0086664  NM_166277   372   45
Additional Transcript Data & Comments
Reported size (kB)	0.48 (northern blot) (Uttenweiler-Joseph et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein IM2-PA   FBpp0085845   4.7   45   8.23     NP_725776   AAF57708
Additional Polypeptide Data & Comments
Reported size (kDa)	46 (aa) (Uttenweiler-Joseph et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Immune-induced protein Dim (IPR013172)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57708   AF074003 AAC62494   AI292815   AX154653   AY071680 AAL49302   BG632261   BG639340   BI564207   BI565053   BI565223   BI565240   BI565373   BI565594   BI565639   BI565669   BI566023   BI566258   BI566450   BI566457   BI566488   BI566491   BI568445   BI568831   BI568832   BI570204   BI570376   BI571393   BI572687   BI574283   BI574917   BI575172   BI575476   BI575936   BI575985   BI576077   BI576561   BI576802   BI576805   BI576858   BI576949   BI583079   BI583828   BI584353   BI584431   BI584464   BI584509   BI584954   BI585459   BI586052   BI586519   BI586615   BI586806   BI587550   BI588307   BI588604   BI592712   BI593519   BI604429   BI604969   BI605513   BI606417   BI607227   BI607290   BI608291   BI609193   BI609394   BI609523   BI609762   BI610493   BI610785   BI611346   BI611528   BI611542   BI613208   BI613642   BI613801   BI614259   BI614315   BI614541   BI616314   BI616668   BI617037   BI617163   BI620694   BI620930   BI620981   BI621802   BI621903   BI622107   BI622427   BI623423   BI624008   BI624600   BI624816   BI624895   BI625933   BI626092   BI627836   BI627951   BI628200   BI629702   BI630639   BI630765   BI630812   BI631236   BI631352   BI631649   BI634278   BI634378   BI634760   BI634797   BI634851   CO186906   CO281531   CO282845   CO301664   EC057490   EC216396   EC222330   EC234069   EC245901   EV576177   EV577446   EV585732   EV593888   EV594877   EV598876   EV599567
UniProtKB/Swiss-Prot	O77150
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage     (Uttenweiler-Joseph et al., 1998)
Additional Descriptive Data
	IM2 transcripts are detected at low levels in adults and increase within 24hr after immune challenge. (Uttenweiler-Joseph et al., 1998)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0025583    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0025583 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed during early pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0025583 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    124 embryo 12-14hr    340 embryo 14-16hr    586 embryo 16-18hr    438 embryo 18-20hr    1029 embryo 20-22hr    5445 embryo 22-24hr    6846 larva L1    757 larva L2    160 larva L3 12hr old    1196 larva L3 puffstage 1-2    1440 larva L3 puffstage 3-6    1763 larva L3 puffstage 7-9    4771 white prepupae new    1357 white prepupae 12hr    21691 white prepupae 24hr    12846 pupae 2d postWPP    6617 pupae 3d postWPP    2879 pupae 4d postWPP    5468 adult male 01day    50314 adult male 05day    21607 adult male 30day    28243 adult female 01day    26926 adult female 05day    10883 adult female 30day    38776 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr  (124) embryo 12-14hr  (340) embryo 14-16hr  (586) embryo 16-18hr  (438) embryo 18-20hr  (1029) embryo 20-22hr  (5445) embryo 22-24hr  (6846) larva L1  (757) larva L2  (160) larva L3 12hr old  (1196) larva L3 puffstage 1-2  (1440) larva L3 puffstage 3-6  (1763) larva L3 puffstage 7-9  (4771) white prepupae new  (1357) white prepupae 12hr  (21691) white prepupae 24hr  (12846) pupae 2d postWPP  (6617) pupae 3d postWPP  (2879) pupae 4d postWPP  (5468) adult male 01day  (50314) adult male 05day  (21607) adult male 30day  (28243) adult female 01day  (26926) adult female 05day  (10883) adult female 30day  (38776) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    124 embryo 12-14hr    340 embryo 14-16hr    586 embryo 16-18hr    438 embryo 18-20hr    1029 embryo 20-22hr  (5445) embryo 22-24hr  (6846) larva L1    757 larva L2    160 larva L3 12hr old    1196 larva L3 puffstage 1-2  1440 larva L3 puffstage 3-6  (1763) larva L3 puffstage 7-9  (4771) white prepupae new    1357 white prepupae 12hr  (21691) white prepupae 24hr  (12846) pupae 2d postWPP  (6617) pupae 3d postWPP  (2879) pupae 4d postWPP  (5468) adult male 01day  (50314) adult male 05day  (21607) adult male 30day  (28243) adult female 01day  (26926) adult female 05day  (10883) adult female 30day  (38776) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    124 embryo 12-14hr    340 embryo 14-16hr    586 embryo 16-18hr    438 embryo 18-20hr    1029 embryo 20-22hr    5445 embryo 22-24hr    6846 larva L1    757 larva L2    160 larva L3 12hr old    1196 larva L3 puffstage 1-2    1440 larva L3 puffstage 3-6    1763 larva L3 puffstage 7-9    4771 white prepupae new    1357 white prepupae 12hr  (21691) white prepupae 24hr  (12846) pupae 2d postWPP    6617 pupae 3d postWPP    2879 pupae 4d postWPP    5468 adult male 01day  (50314) adult male 05day  (21607) adult male 30day  (28243) adult female 01day  (26926) adult female 05day  (10883) adult female 30day  (38776) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    124 embryo 12-14hr    340 embryo 14-16hr    586 embryo 16-18hr    438 embryo 18-20hr    1029 embryo 20-22hr    5445 embryo 22-24hr    6846 larva L1    757 larva L2    160 larva L3 12hr old    1196 larva L3 puffstage 1-2    1440 larva L3 puffstage 3-6    1763 larva L3 puffstage 7-9    4771 white prepupae new    1357 white prepupae 12hr    21691 white prepupae 24hr    12846 pupae 2d postWPP    6617 pupae 3d postWPP    2879 pupae 4d postWPP    5468 adult male 01day    50314 adult male 05day    21607 adult male 30day    28243 adult female 01day    26926 adult female 05day    10883 adult female 30day    38776 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0025583 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    124 embryo 12-14hr    340 embryo 14-16hr    586 embryo 16-18hr    438 embryo 18-20hr    1029 embryo 20-22hr    5445 embryo 22-24hr    6846 larva L1    757 larva L2    160 larva L3 12hr old    1196 larva L3 puffstage 1-2    1440 larva L3 puffstage 3-6    1763 larva L3 puffstage 7-9    4771 white prepupae new    1357 white prepupae 12hr    21691 white prepupae 24hr    12846 pupae 2d postWPP    6617 pupae 3d postWPP    2879 pupae 4d postWPP    5468 adult male 01day    50314 adult male 05day    21607 adult male 30day    28243 adult female 01day    26926 adult female 05day    10883 adult female 30day    38776 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr  124 embryo 12-14hr  (340) embryo 14-16hr  (586) embryo 16-18hr  (438) embryo 18-20hr  (1029) embryo 20-22hr  (5445) embryo 22-24hr  (6846) larva L1  (757) larva L2  (160) larva L3 12hr old  (1196) larva L3 puffstage 1-2  (1440) larva L3 puffstage 3-6  (1763) larva L3 puffstage 7-9  (4771) white prepupae new  (1357) white prepupae 12hr  (21691) white prepupae 24hr  (12846) pupae 2d postWPP  (6617) pupae 3d postWPP  (2879) pupae 4d postWPP  (5468) adult male 01day  (50314) adult male 05day  (21607) adult male 30day  (28243) adult female 01day  (26926) adult female 05day  (10883) adult female 30day  (38776) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    124 embryo 12-14hr    340 embryo 14-16hr    586 embryo 16-18hr    438 embryo 18-20hr    1029 embryo 20-22hr  (5445) embryo 22-24hr  (6846) larva L1    757 larva L2    160 larva L3 12hr old    1196 larva L3 puffstage 1-2  1440 larva L3 puffstage 3-6  1763 larva L3 puffstage 7-9  (4771) white prepupae new    1357 white prepupae 12hr  (21691) white prepupae 24hr  (12846) pupae 2d postWPP  (6617) pupae 3d postWPP  (2879) pupae 4d postWPP  (5468) adult male 01day  (50314) adult male 05day  (21607) adult male 30day  (28243) adult female 01day  (26926) adult female 05day  (10883) adult female 30day  (38776) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    124 embryo 12-14hr    340 embryo 14-16hr    586 embryo 16-18hr    438 embryo 18-20hr    1029 embryo 20-22hr    5445 embryo 22-24hr    6846 larva L1    757 larva L2    160 larva L3 12hr old    1196 larva L3 puffstage 1-2    1440 larva L3 puffstage 3-6    1763 larva L3 puffstage 7-9    4771 white prepupae new    1357 white prepupae 12hr  (21691) white prepupae 24hr  12846 pupae 2d postWPP    6617 pupae 3d postWPP    2879 pupae 4d postWPP    5468 adult male 01day  (50314) adult male 05day  (21607) adult male 30day  (28243) adult female 01day  (26926) adult female 05day  10883 adult female 30day  (38776) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    124 embryo 12-14hr    340 embryo 14-16hr    586 embryo 16-18hr    438 embryo 18-20hr    1029 embryo 20-22hr    5445 embryo 22-24hr    6846 larva L1    757 larva L2    160 larva L3 12hr old    1196 larva L3 puffstage 1-2    1440 larva L3 puffstage 3-6    1763 larva L3 puffstage 7-9    4771 white prepupae new    1357 white prepupae 12hr    21691 white prepupae 24hr    12846 pupae 2d postWPP    6617 pupae 3d postWPP    2879 pupae 4d postWPP    5468 adult male 01day    50314 adult male 05day    21607 adult male 30day    28243 adult female 01day    26926 adult female 05day    10883 adult female 30day    38776 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0025583    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0025583 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, adult Malpighian tubules, larval fat body. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0025583 expression level Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut    18 Larval Hindgut    14.8 Larval Malpighian Tubules    4.3 Larval Fat Body    305.6 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    32.25 Adult Head    2813.9 Adult Eye    1505.55 Adult Brain    68.8 Adult Thoracic-Abdominal Ganglion    69.5 Adult Crop    61.4 Adult Midgut    6.6 Adult Hindgut    151.4 Adult Malpighian Tubules    129.2 Adult Fat Body    4156.7 Adult Salivary Gland no informative data Adult Heart    1721.825 Adult VirginFemale Spermatheca    4245.1 Adult InseminatedFemale Spermatheca    2697.4 Adult Ovary    1.7 Adult Testis    6.2 Adult Male Accessory Gland    8.1 Adult Carcass    2596 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut    18 Larval Hindgut    14.8 Larval Malpighian Tubules    4.3 Larval Fat Body    305.6 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    32.25 Adult Head  (2813.9) Adult Eye  (1505.55) Adult Brain    68.8 Adult Thoracic-Abdominal Ganglion    69.5 Adult Crop    61.4 Adult Midgut    6.6 Adult Hindgut    151.4 Adult Malpighian Tubules    129.2 Adult Fat Body  (4156.7) Adult Salivary Gland no informative data Adult Heart  (1721.825) Adult VirginFemale Spermatheca  (4245.1) Adult InseminatedFemale Spermatheca  (2697.4) Adult Ovary    1.7 Adult Testis    6.2 Adult Male Accessory Gland    8.1 Adult Carcass  (2596) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut    18 Larval Hindgut    14.8 Larval Malpighian Tubules    4.3 Larval Fat Body    305.6 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    32.25 Adult Head  (2813.9) Adult Eye  (1505.55) Adult Brain    68.8 Adult Thoracic-Abdominal Ganglion    69.5 Adult Crop    61.4 Adult Midgut    6.6 Adult Hindgut    151.4 Adult Malpighian Tubules    129.2 Adult Fat Body  (4156.7) Adult Salivary Gland no informative data Adult Heart  (1721.825) Adult VirginFemale Spermatheca  (4245.1) Adult InseminatedFemale Spermatheca  (2697.4) Adult Ovary    1.7 Adult Testis    6.2 Adult Male Accessory Gland    8.1 Adult Carcass  (2596) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut    18 Larval Hindgut    14.8 Larval Malpighian Tubules    4.3 Larval Fat Body    305.6 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    32.25 Adult Head    2813.9 Adult Eye    1505.55 Adult Brain    68.8 Adult Thoracic-Abdominal Ganglion    69.5 Adult Crop    61.4 Adult Midgut    6.6 Adult Hindgut    151.4 Adult Malpighian Tubules    129.2 Adult Fat Body    4156.7 Adult Salivary Gland no informative data Adult Heart    1721.825 Adult VirginFemale Spermatheca    4245.1 Adult InseminatedFemale Spermatheca    2697.4 Adult Ovary    1.7 Adult Testis    6.2 Adult Male Accessory Gland    8.1 Adult Carcass    2596 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0025583 expression level Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut    18 Larval Hindgut    14.8 Larval Malpighian Tubules    4.3 Larval Fat Body    305.6 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    32.25 Adult Head    2813.9 Adult Eye    1505.55 Adult Brain    68.8 Adult Thoracic-Abdominal Ganglion    69.5 Adult Crop    61.4 Adult Midgut    6.6 Adult Hindgut    151.4 Adult Malpighian Tubules    129.2 Adult Fat Body    4156.7 Adult Salivary Gland no informative data Adult Heart    1721.825 Adult VirginFemale Spermatheca    4245.1 Adult InseminatedFemale Spermatheca    2697.4 Adult Ovary    1.7 Adult Testis    6.2 Adult Male Accessory Gland    8.1 Adult Carcass    2596 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut    18 Larval Hindgut    14.8 Larval Malpighian Tubules    4.3 Larval Fat Body    305.6 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    32.25 Adult Head  (2813.9) Adult Eye  (1505.55) Adult Brain    68.8 Adult Thoracic-Abdominal Ganglion    69.5 Adult Crop    61.4 Adult Midgut    6.6 Adult Hindgut    151.4 Adult Malpighian Tubules    129.2 Adult Fat Body  (4156.7) Adult Salivary Gland no informative data Adult Heart  (1721.825) Adult VirginFemale Spermatheca  (4245.1) Adult InseminatedFemale Spermatheca  (2697.4) Adult Ovary    1.7 Adult Testis    6.2 Adult Male Accessory Gland    8.1 Adult Carcass  (2596) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut    18 Larval Hindgut    14.8 Larval Malpighian Tubules    4.3 Larval Fat Body    305.6 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    32.25 Adult Head  (2813.9) Adult Eye  1505.55 Adult Brain    68.8 Adult Thoracic-Abdominal Ganglion    69.5 Adult Crop    61.4 Adult Midgut    6.6 Adult Hindgut    151.4 Adult Malpighian Tubules    129.2 Adult Fat Body  (4156.7) Adult Salivary Gland no informative data Adult Heart  (1721.825) Adult VirginFemale Spermatheca  (4245.1) Adult InseminatedFemale Spermatheca  (2697.4) Adult Ovary    1.7 Adult Testis    6.2 Adult Male Accessory Gland    8.1 Adult Carcass  (2596) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut    18 Larval Hindgut    14.8 Larval Malpighian Tubules    4.3 Larval Fat Body    305.6 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    32.25 Adult Head    2813.9 Adult Eye    1505.55 Adult Brain    68.8 Adult Thoracic-Abdominal Ganglion    69.5 Adult Crop    61.4 Adult Midgut    6.6 Adult Hindgut    151.4 Adult Malpighian Tubules    129.2 Adult Fat Body    4156.7 Adult Salivary Gland no informative data Adult Heart    1721.825 Adult VirginFemale Spermatheca    4245.1 Adult InseminatedFemale Spermatheca    2697.4 Adult Ovary    1.7 Adult Testis    6.2 Adult Male Accessory Gland    8.1 Adult Carcass    2596 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2813.9   NA  Eye    1505.55   NA  Brain    68.8   6.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    69.5   NA  Crop    61.4   18  Midgut    6.6   14.8  Hindgut    151.4   4.3  Malpighian Tubules    129.2   305.6  Fat Body    4156.7   no informative data  Salivary Gland    no informative data   NA  Heart    1721.825   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    4245.1   NA  InseminatedFemale Spermatheca    2697.4   NA  Ovary    1.7   NA  Testis    6.2   NA  Male Accessory Gland    8.1   32.25  Carcass    2596 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025583 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18106-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 IM2GD4543 IM2GD15375 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of IM2 Class Mutagen Stocks Known lesion IM2MI01019 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of IM2 Class Mutagen Stocks Known lesion IM2GD15375 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes IM2GD4543 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes IM2JF03216 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4543} NA P{GD15375} NA P{TRiP.JF03216} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}IM2MI01019 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
defense response inferred from direct assay (Uttenweiler-Joseph et al., 1998)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (Uttenweiler-Joseph et al., 1998)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
defense response non-traceable author statement (assigned by UniProtKB) (Baggerman et al., 2002)
Cellular Component
CV term Evidence References
extracellular region non-traceable author statement (assigned by UniProtKB) (Baggerman et al., 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions IM2 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0025583 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49802
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA14796
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0225194 FBgn0224939 FBgn0207027 FBgn0183114 FBgn0176745 FBgn0074823 FBgn0155367 FBgn0142851 FBgn0129126 FBgn0121410 FBgn0114054 FBgn0089194
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	28788 y1 v1; P{TRiP.JF03216}attP2 32727 y1 w*; Mi{MIC}IM2MI01019
VDRC	v10586 w1118; P{GD4543}v10586 v43371 w1118; P{GD15375}v43371 v43372 w1118; P{GD15375}v43372 v46291 w1118; P{GD15375}v46291
Genomic Clones ( 2 )
	BACR14N05 BACR48A20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 123 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH08291
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05821 GH15816 RH02485 RH02688 RH06411 RH10477 RH11610 RH12488 RH13944 RH14168 RH14318 RH14588 RH15984 RH16587 RH17543 RH17870 RH21524 RH22529 RH23047 RH23534 RH23633 RH23677 RH23735 RH24306 RH25046 RH25775 RH26484 RH26686 RH26911 RH27466 RH28250 RH28457 RH29470 RH29982 RH31148 RH32343 RH32424 RH32575 RH33148 RH33441 RH33444 RH33505 RH33644 RH35116 RH35459 RH35694 RH35960 RH36006 RH36047 RH36052 RH38012 RH38423 RH38987 RH39034 RH39094 RH42314 RH42844 RH43042 RH43591 RH43931 RH46225 RH46714 RH47242 RH47409 RH51888 RH52192 RH52251 RH53215 RH53930 RH54295 RH55670 RH56380 RH56540 RH58608 RH59920 RH60062 RH60118 RH60770 RH60903 RH62711 RH62937 RH62960 RH63389 RH63442 RH63476 RH64186 RH64515 RH64623 RH66443 RH66627 RH69290 RH69456 RH69776 RH70477 RH71147 RH72876 RH74245 RH74325
Other clones	42359 45275 55208 193969 CK01.28D.E1 Dmel_dig_000018_0673_0349 Dmel_dig_014838_0653_2565 Dmel_dig_017552_0615_1332 Dmel_neb_010747_0580_0543 Dmel_neb_012278_0609_1199 Dmel_neb_013016_0946_2423 Dmel_neb_014649_0909_2231 EK024717 EK157363 EK161437 EK181841 LP05316 RH01128 RH17852 RH39893 RH43661 RH53467 RH61269 RH63137
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025583 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49802
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: IM2 anon-WO0140519.2 (FlyBase, 1996-) Source for merge of: IM2 BcDNA:RH08291 (FlyBase, 1996-) Source for merge of: IM2 CG18106 (Bayraktaroglu, 2000.4.7)
Additional comments	Source for merge of IM2 anon-WO0140519.2 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of IM2 BcDNA:RH08291 was TrEMBL update (date:020807). (FlyBase, 1996-)
Other Comments
	Identification: Encodes a protein that is induced by immune challenge. (Uttenweiler-Joseph et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_166277 RefSeq (Proteins) • NP_725776 DDBJ / EMBL / GenBank • AAC62494 AAF57708 AAL49302 AF074003 AX154653 AY071680 BI572687 Entrez Gene - A searchable database of RefSeq genes. • 49802 UniProtKB/Swiss-Prot • O77150
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Immune-induced protein Dim (IPR013172)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0025583 DRSC - Results from RNAi screens. • FBgn0025583 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025583 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18106-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025583 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49802 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49802 modMine - Data generated by the modENCODE project. • FBgn0025583 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0225194 FBgn0224939 FBgn0207027 FBgn0183114 FBgn0176745 FBgn0074823 FBgn0155367 FBgn0142851 FBgn0129126 FBgn0121410 FBgn0114054 FBgn0089194
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	anon-WO0140519.2   BcDNA:RH08291   CG18106 (De Gregorio et al., 2001, Goldman and Arbeitman, 2007, Roxstrom-Lindquist et al., 2004, Perkins et al., 2009, Hernandez-Romano et al., 2008, Wertheim et al., 2005) DIM2 (Baggerman et al., 2002, Uttenweiler-Joseph, 1998.6.24, Uttenweiler-Joseph et al., 1998, ) DIM-2 (Hernandez-Romano et al., 2008) Im2 (Boutanaev et al., 2002, Curtis et al., 2007) IM2 (Reiter et al., 2007, Stahl et al., 2007, Busse et al., 2007, Carpenter et al., 2009, Obbard et al., 2009, Blanco et al., 2008, Wertheim et al., 2005, Valanne et al., 2010, Zsindely et al., 2009, Kong et al., 2010, Gerbasi et al., 2011)
Name Synonym	Immune induced molecule 2   immune induced molecule 2 (Goldman and Arbeitman, 2007) Immune-induced peptide 2 precursor (Hernandez-Romano et al., 2008) Immune molecule 2 (McGraw et al., 2008)
Secondary FlyBase IDs
	FBgn0034332 FBgn0044675 FBgn0047046
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 4 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Patent  ( 1 )
Recent research papers ( 3 )
	Gerbasi et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(8): 3204--3209 Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis. [FBrf0213185] Kong et al., 2010, Alcoholism, Clin. Exp. Res. 34(2): 302--316 Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. [FBrf0209720] Valanne et al., 2010, J. Immunol. 184(11): 6188--6198 Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. [FBrf0210846] Show all research papers ...