FB2020_02, released Apr 14, 2020

Gene: Dmel\AkhR

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General Information
Symbol
Dmel\AkhR
Species
D. melanogaster
Name
Adipokinetic hormone receptor
Annotation Symbol
CG11325
Feature Type
protein_coding_gene
FlyBase ID
FBgn0025595
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Snapshot
Adipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. [Date last reviewed: 2019-07-11]
Other Summaries
Also Known As

GRHR, Gonadotropin-releasing hormone receptor, AKH receptor, DGRHR

Key Links
Genomic Location
Cytogenetic map
27A1-27A1
Sequence location
2L:6,711,286..6,716,186 [-]
Recombination map

2-22

RefSeq locus
NT_033779 REGION:6711286..6716186
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
adipokinetic hormone binding; adipokinetic hormone receptor activity
Predictions / Assertions
adipokinetic hormone receptor activity; G protein-coupled receptor activity; neuropeptide receptor activity; peptide binding
Summaries
Gene Group (FlyBase)
CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS -
The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).
Summary (Interactive Fly)

GPCR - involved in storage-fat mobilization - essential to adjust normal body fat content and ensure lifelong fat-storage homeostasis - functional analog of the mammalian glucagon receptor

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\AkhR or the JBrowse view of Dmel\AkhR for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
AkhR-RA
FBtr0079308
NM_058039
2031
443
AkhR-RB
FBtr0079309
NM_164705
2781
443
AkhR-RC
FBtr0079310
NM_205917
2022
455
AkhR-RD
FBtr0332331
NM_001273220
2587
443
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
AkhR-PA
FBpp0078938
50.2
443
9.56
NP_477387
AAF52426
AkhR-PB
FBpp0078939
50.2
443
9.56
NP_723206
AAN10595
AkhR-PC
FBpp0089220
51.4
455
9.38
NP_995639
AAS64647
AkhR-PD
FBpp0304609
50.2
443
9.56
NP_001260149
AGB92685
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

443 aa isoforms: AkhR-PA, AkhR-PB, AkhR-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AkhR using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (15 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
adipokinetic hormone binding
inferred from physical interaction with FLYBASE:Akh; FB:FBgn0004552
(Staubli et al., 2002)
adipokinetic hormone receptor activity
inferred from direct assay
(Park et al., 2002, Staubli et al., 2002)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
adipokinetic hormone receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN001202404
(assigned by GO_Central )
(Gaudet et al., 2011)
G protein-coupled receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN001202348
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity
(Radford et al., 2002)
neuropeptide receptor activity
inferred from sequence model
(Hewes and Taghert, 2001)
peptide binding
inferred from biological aspect of ancestor with PANTHER:PTN001202348
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
carbohydrate homeostasis
inferred from mutant phenotype
(Bharucha et al., 2008)
cellular response to starvation
inferred from mutant phenotype
(Rajan et al., 2017)
G protein-coupled receptor signaling pathway
inferred from direct assay
(Park et al., 2002, Staubli et al., 2002)
glucose homeostasis
inferred from mutant phenotype
(Song et al., 2017)
lipid catabolic process
inferred from mutant phenotype
(Grönke et al., 2007)
lipid homeostasis
inferred from mutant phenotype
(Rajan et al., 2017, Grönke et al., 2007)
triglyceride homeostasis
inferred from mutant phenotype
(Bharucha et al., 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cellular response to hormone stimulus
inferred from biological aspect of ancestor with PANTHER:PTN001202348
(assigned by GO_Central )
(Gaudet et al., 2011)
G protein-coupled receptor signaling pathway
inferred from sequence model
(Hewes and Taghert, 2001)
inferred from biological aspect of ancestor with PANTHER:PTN001202348
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
integral component of membrane
inferred from direct assay
(Staubli et al., 2002)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
integral component of membrane
inferred from sequence model
(Hewes and Taghert, 2001)
integral component of plasma membrane
inferred from sequence model
(Park et al., 2002)
inferred by curator from GO:0007186,GO:0097003
(Park et al., 2002)
inferred from biological aspect of ancestor with PANTHER:PTN001202348
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16 -- 17
embryonic/larval fat body
(Grönke et al., 2007)
third instar larval stage
embryonic/larval fat body
(Grönke et al., 2007)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
neuron of adult subesophageal zone | subset
(Yu et al., 2016)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
integral component of membrane
inferred from direct assay
(Staubli et al., 2002)
Expression Deduced from Reporters
Reporter: P{AkhR-Gal4.B}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult fat body
(Bharucha et al., 2008)
gustatory receptor neuron | subset
(Bharucha et al., 2008)
Reporter: P{AkhR-GAL4.Y}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
neuron of adult subesophageal zone | subset
(Yu et al., 2016)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\AkhR in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of AkhR
Transgenic constructs containing regulatory region of AkhR
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GNRHR
12 of 15
Yes
Yes
Hsap\GNRHR2
5 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gnrhr
11 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Gnrhr
10 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\gnrhr2
10 of 12
Yes
Yes
Xtro\gnrhr
6 of 12
No
Yes
Xtro\gnrhr2/nmi
3 of 12
No
Yes
Danio rerio (Zebrafish) (4)
Drer\gnrhr4
11 of 15
Yes
Yes
Drer\gnrhr1
7 of 15
No
Yes
Drer\gnrhr2
7 of 15
No
Yes
Drer\gnrhr3
5 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\gnrr-1
14 of 15
Yes
Yes
Cele\daf-38
4 of 15
No
Yes
Cele\gnrr-2
3 of 15
No
Yes
Cele\gnrr-5
3 of 15
No
Yes
Cele\gnrr-6
2 of 15
No
No
Cele\gnrr-7
2 of 15
No
Yes
Cele\gnrr-3
1 of 15
No
No
Cele\gnrr-4
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091908CT )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001466
Drosophila simulans
Dsim\GD22549
Drosophila sechellia
Dsec\GM13935
Drosophila erecta
Dere\GG23593
Drosophila yakuba
Dyak\GE18412
Drosophila ananassae
Dana\GF14951
Drosophila pseudoobscura pseudoobscura
Dpse\GA10920
Drosophila persimilis
Dper\GL25969
Drosophila willistoni
Dwil\GK24218
Drosophila virilis
Dvir\GJ15464
Drosophila mojavensis
Dmoj\GI17543
Drosophila grimshawi
Dgri\GH11026
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915053U )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17021116
Glossina morsitans
Tsetse fly
Gmor\GMOY008368
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07910
Mayetiola destructor
Hessian fly
Mdes\Mdes006948
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011325
Anopheles darlingi
American malaria mosquito
Adar\ADAC000763
Anopheles gambiae
Malaria mosquito
Agam\GPRGNR1
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06HI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002767
Danaus plexippus
Monarch butterfly
Dple\DPOGS210475-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011945
Apis florea
Little honeybee
Aflo\3178271140
Apis mellifera
Western honey bee
Amel\GB53230
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25350
Bombus terrestris
Buff-tailed bumblebee
Bter\15207306
Linepithema humile
Argentine ant
Lhum\LH20761
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001e91
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013042
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05822
Tribolium castaneum
Red flour beetle
Tcas\akhr
Pediculus humanus
Human body louse
Phum\PHUM370810
Cimex lectularius
Bed bug
Clec\CLEC001064
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002471
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10533
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06D9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009828
Strigamia maritima
European centipede
Smar\SMAR006353
Ixodes scapularis
Black-legged tick
Isca\ISCW019342
Ixodes scapularis
Black-legged tick
Isca\ISCW008018
Ixodes scapularis
Black-legged tick
Isca\ISCW000658
Ixodes scapularis
Black-legged tick
Isca\ISCW011612
Ixodes scapularis
Black-legged tick
Isca\ISCW000195
Ixodes scapularis
Black-legged tick
Isca\ISCW019339
Ixodes scapularis
Black-legged tick
Isca\ISCW017422
Ixodes scapularis
Black-legged tick
Isca\ISCW003272
Ixodes scapularis
Black-legged tick
Isca\ISCW001755
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59015.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64201.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63223.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g09980
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g04150
Tetranychus urticae
Two-spotted spider mite
Turt\tetur13g02680
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g03910
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_40643
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G111M )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\gnrhr2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cpp
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_027749gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020114
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004578
Ciona intestinalis
Vase tunicate
Cint\gnrhr3
Gallus gallus
Domestic chicken
Ggal\GNRHR
Gallus gallus
Domestic chicken
Ggal\CGNRH-R
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (7)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CrzR
3 of 10
SIFaR
2 of 10
CCAP-R
1 of 10
CCKLR-17D1
1 of 10
CCKLR-17D3
1 of 10
RYa-R
1 of 10
TrissinR
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Allele
Disease
Evidence
References
AkhRGD586
model of  obesity
CEA
(Baumbach et al., 2014)
AkhR1
model of  obesity
CEA
(Baumbach et al., 2014)
AkhRHMC03228
model of  obesity
CEA
(Xu et al., 2019)
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
AkhR1
exacerbates  obesity
modeled by Lsd-11
(Beller et al., 2010)
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
GNRHR; gonadotropin releasing hormone receptor
12 of 15
138850
GNRHR2; gonadotropin releasing hormone receptor 2 (pseudogene)
5 of 15
612875
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      AkhR - Akh
      biochemical, Identification by mass spectrometry, inferred by author, luminiscence technology, enzymatic study
      (Caers et al., 2012, Park et al., 2002, Staubli et al., 2002)
      AkhR - CCAP
      enzymatic study, inferred by author
      (Park et al., 2002)
      AkhR - Crz
      enzymatic study, inferred by author
      (Park et al., 2002)
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      DCTN1-p150
      suppressible
      AkhR
      (Chang et al., 2013)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2L
      Recombination map

      2-22

      Cytogenetic map
      27A1-27A1
      Sequence location
      2L:6,711,286..6,716,186 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      27A1-27A1
      Limits computationally determined from genome sequence between P{EP}Sec61αEP2180 and P{lacW}Ate1k10809
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      27A2-27B2
      (Hauser, 1998.7.7)
      Experimentally Determined Recombination Data
      Location

      2-22

      (FlyBase, 2016)

      2-21.6

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (12)
      Genomic Clones (19)
      cDNA Clones (11)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: GRHR CG11325

      (Wortman, 1999.11)
      Source for database merge of

      Source for merge of: GRHR BEST:GH19447

      (Rana, 2004.7.8)
      Additional comments
      Other Comments
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 58 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (25)
      Reported As
      Symbol Synonym
      AKH-R
      (Rasmussen et al., 2015)
      AKHR
      (Zheng et al., 2019, Lehmann, 2018, Marchal et al., 2018, Rizzo et al., 2018, Mattila and Hietakangas, 2017, Rajan et al., 2017, Nässel and Vanden Broeck, 2016, Zheng et al., 2016, Choi et al., 2015, Yurgel et al., 2015, Chandrashekara et al., 2014, Rajan and Perrimon, 2013, Palm et al., 2012, Musselman et al., 2011, Wang et al., 2011, Beller et al., 2010, Beller et al., 2010, Iijima et al., 2009, Sieber and Thummel, 2009, Grönke et al., 2007)
      Akh-R
      (Strigini and Leulier, 2016)
      AkhR
      (Kondo et al., 2020, Xu et al., 2020, Lin et al., 2019, Rao and Deng, 2019.10.23, Xu et al., 2019, Xu et al., 2019, Gene Disruption Project members, 2018-, Hemphill et al., 2018, Levis, 2018.8.30, Ugrankar et al., 2018, Gáliková et al., 2017, Song et al., 2017, Transgenic RNAi Project members, 2017-, Alfa and Kim, 2016, Cao et al., 2016, Wiemerslage et al., 2016, Alfa et al., 2015, Gáliková et al., 2015, Matsuda et al., 2015, Metaxakis et al., 2014, Waterson et al., 2014)
      AkhR/GRHR
      (Kučerová et al., 2016)
      Akhr
      (Bharucha et al., 2008)
      Akhr/GRHR
      (Kühnlein, 2010)
      BEST:GH19447
      CG11325
      (Kondo et al., 2020, Metaxakis et al., 2014, Nässel and Winther, 2010, Ni et al., 2010.12.1, Fujikawa et al., 2009, Keleman et al., 2009.8.5, Mohammad et al., 2009, Perkins et al., 2009, Grieder et al., 2007, Grönke et al., 2007, Hauser et al., 2006, Hauser et al., 2006, Bryson-Richardson et al., 2004, Park et al., 2002)
      DAKHR
      (Cazzamali et al., 2003)
      DAKHR-1
      (Staubli et al., 2002)
      DGRHR
      (Hauser, 1998.7.7, Hauser et al., 1998)
      GRHR
      (Lou et al., 2017, Caers et al., 2012, Izutsu et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jungreis, 2011.11.18, Fujikawa et al., 2009, Brody and Cravchik, 2000)
      GRHR/CG11325
      (Hewes and Taghert, 2001.7.31)
      GnRHR
      (Staubli et al., 2002)
      akhr
      (Wang et al., 2016, Hentze et al., 2015, Pospisilik et al., 2010, Righi et al., 2010)
      Name Synonyms
      AKH receptor
      (Owusu-Ansah and Perrimon, 2014, Veenstra et al., 2008, Staubli et al., 2002)
      Adipokinetic Hormone Receptor
      (Palm et al., 2012)
      Adipokinetic hormone receptor
      (Alfa and Kim, 2016, Yu et al., 2016, Yurgel et al., 2015, Caers et al., 2012)
      Drm-AKH receptor-1
      (Staubli et al., 2002)
      Gonadotropin-releasing hormone receptor
      (Felix et al., 2012, Staubli et al., 2002)
      adipokinetic hormone receptor
      (Beller et al., 2010, Bharucha et al., 2008)
      gonadotrophin-releasing hormone receptor
      (Zou et al., 2000)
      gonadotropin-releasing hormone receptor
      (Eleftherianos and Castillo, 2012, Hauser, 1998.7.7)
      hormone receptor
      (Zou et al., 2000)
      Secondary FlyBase IDs
      • FBgn0043817
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (133)