FlyBase Gene Report: Dmel\AkhR

General Information

Symbol

Dmel\AkhR

Species

D. melanogaster

Name

Adipokinetic hormone receptor

Annotation Symbol

CG11325

Feature Type

protein_coding_gene

FlyBase ID

FBgn0025595

Gene Model Status

Stock Availability

12 publicly available

Gene Snapshot

Adipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. [Date last reviewed: 2019-07-11]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

GRHR, DGRHR, AKH receptor, Gonadotropin-releasing hormone receptor

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:6,711,286..6,716,186 [-]

Recombination map

2-22

RefSeq locus

NT_033779 REGION:6711286..6716186

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables adipokinetic hormone binding

inferred from physical interaction with FLYBASE:Akh; FB:FBgn0004552

(Staubli et al., 2002)

enables adipokinetic hormone receptor activity

inferred from direct assay

(Park et al., 2002, Staubli et al., 2002)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables adipokinetic hormone receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001202404

(assigned by GO_Central )

(Gaudet et al., 2011)

enables G protein-coupled receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000662653

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity

(Radford et al., 2002)

enables neuropeptide receptor activity

inferred from sequence model

(Hewes and Taghert, 2001)

enables peptide binding

inferred from biological aspect of ancestor with PANTHER:PTN001202348

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in carbohydrate homeostasis

inferred from mutant phenotype

(Bharucha et al., 2008)

involved_in cellular response to starvation

inferred from mutant phenotype

(Rajan et al., 2017)

involved_in G protein-coupled receptor signaling pathway

inferred from direct assay

(Park et al., 2002, Staubli et al., 2002)

involved_in glucose homeostasis

inferred from mutant phenotype

(Song et al., 2017)

involved_in lipid catabolic process

inferred from mutant phenotype

(Grönke et al., 2007)

involved_in lipid homeostasis

inferred from mutant phenotype

(Rajan et al., 2017, Grönke et al., 2007)

involved_in triglyceride homeostasis

inferred from mutant phenotype

(Bharucha et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from sequence model

(Hewes and Taghert, 2001)

inferred from biological aspect of ancestor with PANTHER:PTN000662653

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in integral component of membrane

inferred from direct assay

(Staubli et al., 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence model

(Hewes and Taghert, 2001)

located_in integral component of plasma membrane

inferred from sequence model

(Park et al., 2002)

inferred by curator from GO:0007186,GO:0097003

(Park et al., 2002)

inferred from biological aspect of ancestor with PANTHER:PTN000662653

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS -: The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).

Summary (Interactive Fly)

GPCR - involved in storage-fat mobilization - essential to adjust normal body fat content and ensure lifelong fat-storage homeostasis - functional analog of the mammalian glucagon receptor

Interactive Fly

Gene Model and Products

Number of Transcripts

4

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\AkhR for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.45

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0079308

2031

443

FBtr0079309

2781

443

FBtr0079310

2022

455

FBtr0332331

2587

443

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0078938

50.2

443

9.56

FBpp0078939

50.2

443

9.56

FBpp0089220

51.4

455

9.38

FBpp0304609

50.2

443

9.56

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

443 aa isoforms: AkhR-PA, AkhR-PB, AkhR-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AkhR using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

AkhR_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

embryonic/larval fat body

(Grönke et al., 2007)

third instar larval stage

embryonic/larval fat body

(Grönke et al., 2007)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

neuron of adult subesophageal zone | subset

(Yu et al., 2016)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in integral component of membrane

inferred from direct assay

(Staubli et al., 2002)

Expression Deduced from Reporters

Reporter: P{AkhR-Gal4.B}

Stage

Tissue/Position (including subcellular localization)

Reference

(Bharucha et al., 2008)

gustatory receptor neuron | subset

(Bharucha et al., 2008)

Reporter: P{AkhR-GAL4.Y}

Stage

Tissue/Position (including subcellular localization)

Reference

neuron of adult subesophageal zone | subset

(Yu et al., 2016)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\AkhR in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\AkhR

View exonic expression by tissue for Dmel\AkhR

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025595

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0025595

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG11325-RB;CG11325-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11325

Flygut - An atlas of the Drosophila adult midgut

FBgn0025595

Images

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 18 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of AkhR

Transgenic constructs containing regulatory region of AkhR

Deletions and Duplications ( 1 )

Disrupted in

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^Mef2.PR

AkhR^GD586

viable, with Scer\GAL4^pnr-MD237

AkhR^GD586

viable, with Scer\GAL4^tin.CΔ4

AkhR^GD586

Sterility

Allele

Other Phenotypes

Allele

developmental rate defective

AkhR¹

hypoactive | adult stage | nutrition conditional, with Scer\GAL4^elav.PU

AkhR^JF03256

hypoactive | adult stage | nutrition conditional, with Scer\GAL4^nSyb.PY

AkhR^JF03256

hypoactive | adult stage | nutrition conditional, with Scer\GAL4^Tdc2.PC

AkhR^JF03256

hypoactive | adult stage | recessive | nutrition conditional

AkhR¹

oxidative stress response defective | adult stage

AkhR¹

starvation stress response defective | adult stage

AkhR¹

starvation stress response defective | adult stage, with Scer\GAL4^elav.PU

AkhR^JF03256

starvation stress response defective | adult stage, with Scer\GAL4^nSyb.PY

AkhR^JF03256

starvation stress response defective | adult stage, with Scer\GAL4^Tdc2.PC

AkhR^JF03256

starvation stress response defective | adult stage | recessive

AkhR¹

stress response defective

Phenotype manifest in

Allele

AkhR^null

embryonic/larval midgut | third instar larval stage

AkhR¹

lipid droplet (with AkhR¹)

AkhR²

lipid droplet (with AkhR²)

AkhR¹

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

12 of 15

Yes

Yes

5 of 15

No

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

11 of 15

Yes

Yes

Rattus norvegicus (Norway rat) (1)

10 of 13

Yes

Yes

Xenopus tropicalis (Western clawed frog) (3)

10 of 12

Yes

Yes

6 of 12

No

Yes

Xtro\gnrhr2/nmi

3 of 12

No

Yes

Danio rerio (Zebrafish) (4)

11 of 15

Yes

Yes

7 of 15

No

Yes

7 of 15

No

Yes

5 of 15

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (8)

14 of 15

Yes

Yes

4 of 15

No

Yes

3 of 15

No

Yes

3 of 15

No

Yes

2 of 15

No

No

2 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091908CT )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00001466

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915053U )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY008368

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07910

Mayetiola destructor

Hessian fly

Mdes\Mdes006948

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL011325

Anopheles darlingi

American malaria mosquito

Adar\ADAC000763

Anopheles gambiae

Malaria mosquito

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06HI )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA002767

Danaus plexippus

Monarch butterfly

Dple\DPOGS210475-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL011945

Apis florea

Little honeybee

Aflo\3178271140

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001e91

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG013042

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM370810

Cimex lectularius

Bed bug

Clec\CLEC001064

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002471

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10533

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06D9 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR009828

Strigamia maritima

European centipede

Smar\SMAR006353

Ixodes scapularis

Black-legged tick

Isca\ISCW019342

Ixodes scapularis

Black-legged tick

Isca\ISCW008018

Ixodes scapularis

Black-legged tick

Isca\ISCW000658

Ixodes scapularis

Black-legged tick

Isca\ISCW011612

Ixodes scapularis

Black-legged tick

Isca\ISCW000195

Ixodes scapularis

Black-legged tick

Isca\ISCW019339

Ixodes scapularis

Black-legged tick

Isca\ISCW017422

Ixodes scapularis

Black-legged tick

Isca\ISCW003272

Ixodes scapularis

Black-legged tick

Isca\ISCW001755

Stegodyphus mimosarum

African social velvet spider

Smim\KFM59015.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM64201.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63223.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur02g09980

Tetranychus urticae

Two-spotted spider mite

Turt\tetur06g04150

Tetranychus urticae

Two-spotted spider mite

Turt\tetur13g02680

Tetranychus urticae

Two-spotted spider mite

Turt\tetur02g03910

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_40643

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G111M )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_027749gn

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000020114

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000004578

Ciona intestinalis

Vase tunicate

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (7)

Gene Symbol

Score

Source

Alignment

3 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

model of obesity

CEA

(Baumbach et al., 2014)

model of obesity

CEA

(Baumbach et al., 2014)

model of obesity

CEA

(Xu et al., 2019)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

GNRHR; gonadotropin releasing hormone receptor

model of hypogonadotropic hypogonadism 7 with or without anosmia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

exacerbates obesity

modeled by Lsd-1¹

(Beller et al., 2010)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GNRHR; gonadotropin releasing hormone receptor

12 of 15

HYPOGONADOTROPIC HYPOGONADISM 7 WITH OR WITHOUT ANOSMIA; HH7

hypogonadotropic hypogonadism 7 with or without anosmia

GNRHR2; gonadotropin releasing hormone receptor 2 (pseudogene)

5 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

enzymatic study, inferred by author, biochemical, Identification by mass spectrometry, luminiscence technology

(Caers et al., 2012, Park et al., 2002, Staubli et al., 2002)

enzymatic study, inferred by author

(Park et al., 2002)

enzymatic study, inferred by author

(Park et al., 2002)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Chang et al., 2013)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60095

DroID - A comprehensive database of gene and protein interactions.

FBgn0025595

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

33942

MIST (protein-protein) - An integrated Molecular Interaction Database

AkhR

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Neuroactive ligand-receptor interaction

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-22

Cytogenetic map

Sequence location

2L:6,711,286..6,716,186 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

27A1-27A1

Limits computationally determined from genome sequence between P{EP}Sec61α^EP2180 and P{lacW}Ate1^k10809

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

27A2-27B2

(Hauser, 1998.7.7)

Experimentally Determined Recombination Data

Location

2-22

(FlyBase, 2016)

2-21.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

80937

84449

w^*; TI{TI}AkhR^attP

29577

y¹ v¹; P{TRiP.JF03256}attP2

51710

y¹ v¹; P{TRiP.HMC03228}attP40

84355

w^*; TI{2A-lexA::GAD}AkhR^2A-C.lexA

20304

y¹ w^67c23; P{EPgy2}AkhR^EY11371

78877

y¹ w^*; TI{CRIMIC.GT36}AkhR^CR00132/SM6a

76451

y¹ sc^* v¹ sev²¹; P{TKO.GS00625}attP40

79666

y¹ sc^* v¹ sev²¹; P{TOE.GS01233}attP40

11320

w¹¹¹⁸; PBac{PB}CG15443^c03956 PBac{PB}AkhR^c03956

v109300

P{KK101966}VIE-260B

v9546

w¹¹¹⁸; P{GD586}v9546/TM3

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (11)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH21228

Other clones

GH19447

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0025595

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

GH20680

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0025595

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33942

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: GRHR CG11325

(Wortman, 1999.11)

Source for database merge of

Source for merge of: GRHR BEST:GH19447

(Rana, 2004.7.8)

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 58 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33942

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025595

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0025595

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

AkhR_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11325

Flygut - An atlas of the Drosophila adult midgut

FBgn0025595

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33942

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG11325

modMine - A data warehouse for the modENCODE project

FBgn0025595

Linkouts

BioGRID - A database of protein and genetic interactions.

60095

DroID - A comprehensive database of gene and protein interactions.

FBgn0025595

DRSC - Results frm RNAi screens

FBgn0025595

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0025595

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG11325-RB;CG11325-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0025595

FlyMine - An integrated database for Drosophila genomics

FBgn0025595

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

33942

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Neuroactive ligand-receptor interaction

MIST (protein-protein) - An integrated Molecular Interaction Database

AkhR

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

AKH-R

(Rasmussen et al., 2015)

Akh-R

(Strigini and Leulier, 2016)

AkhR/GRHR

(Kučerová et al., 2016)

Akhr

(Bharucha et al., 2008)

Akhr/GRHR

(Kühnlein, 2010)

BEST:GH19447

CG11325

(Kondo et al., 2020, Metaxakis et al., 2014, Nässel and Winther, 2010, Ni et al., 2010.12.1, Fujikawa et al., 2009, Keleman et al., 2009.8.5, Mohammad et al., 2009, Perkins et al., 2009, Grieder et al., 2007, Grönke et al., 2007, Hauser et al., 2006, Hauser et al., 2006, Bryson-Richardson et al., 2004, Park et al., 2002)

DAKHR

(Cazzamali et al., 2003)

DAKHR-1

(Staubli et al., 2002)

DGRHR

(Hauser, 1998.7.7, Hauser et al., 1998)

GRHR

(Lou et al., 2017, Caers et al., 2012, Izutsu et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jungreis, 2011.11.18, Fujikawa et al., 2009, Brody and Cravchik, 2000)

GRHR/CG11325

(Hewes and Taghert, 2001.7.31)

GnRHR

(Staubli et al., 2002)

akhr

(Wang et al., 2016, Hentze et al., 2015, Pospisilik et al., 2010, Righi et al., 2010)

Name Synonyms

AKH receptor

(Owusu-Ansah and Perrimon, 2014, Veenstra et al., 2008, Staubli et al., 2002)

Adipokinetic Hormone Receptor

(Palm et al., 2012)

Adipokinetic hormone receptor

(Alfa and Kim, 2016, Yu et al., 2016, Yurgel et al., 2015, Caers et al., 2012)

Drm-AKH receptor-1

(Staubli et al., 2002)

Gonadotropin-releasing hormone receptor

(Felix et al., 2012, Staubli et al., 2002)

adipokinetic hormone receptor

(Newell et al., 2020, Beller et al., 2010, Bharucha et al., 2008)

gonadotrophin-releasing hormone receptor

(Zou et al., 2000)

gonadotropin-releasing hormone receptor

(Eleftherianos and Castillo, 2012, Hauser, 1998.7.7)

hormone receptor

(Zou et al., 2000)

Secondary FlyBase IDs

FBgn0043817

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (138)