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Gene Dmel\CG4025

General Information
Symbol	Dmel\CG4025	Species	D. melanogaster
Name		Annotation symbol	CG4025
Feature type	protein_coding_gene	FlyBase ID	FBgn0025624
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	EG:22E5.9
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	2C10-2C10	Sequence location	X:1,971,015..1,972,488 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG4025 (FBgn0025624). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Frag1/DRAM/Sfk1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed during late larval stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult brain, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634300_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG4025. Gene sequence location is X:1971015..1972488.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN27478 HFA18523
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 2C10-2C10   Limits computationally determined from genome sequence between P{EP}ActnEP1193&P{EP}CG4322EP1631 and P{EP}EP1460&P{EP}CG2924EP1596
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG4025 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG4025-RA FBtr0070375  NM_130623   1224   246
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG4025-PA   FBpp0070359   27.8   246   7.53     NP_569979   AAF45721
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Frag1/DRAM/Sfk1 (IPR019402)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF45721   AI062397   AI296752   AI542334   AL031765 CAA21131   AX154820   AY118613 AAM49982   AY232228   BI637906   BI639619   CO156736   CO189871   CO273627   CO326059   CO336663   CO337253   DN154042   EC213970   EC218236   EC222708   EC232506   EC245646   EC254364   EC263075   EC266976   ES692407
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O77262
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0025624    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0025624 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed during late larval stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0025624 expression level Developmental Stage   Expression Level embryo 00-02hr    1274 embryo 02-04hr    480 embryo 04-06hr    663 embryo 06-08hr    988 embryo 08-10hr    1029 embryo 10-12hr    1044 embryo 12-14hr    652 embryo 14-16hr    785 embryo 16-18hr    647 embryo 18-20hr    599 embryo 20-22hr    611 embryo 22-24hr    626 larva L1    778 larva L2    675 larva L3 12hr old    758 larva L3 puffstage 1-2    1912 larva L3 puffstage 3-6    1882 larva L3 puffstage 7-9    1655 white prepupae new    1368 white prepupae 12hr    1392 white prepupae 24hr    1240 pupae 2d postWPP    955 pupae 3d postWPP    698 pupae 4d postWPP    765 adult male 01day    1196 adult male 05day    1500 adult male 30day    1724 adult female 01day    1394 adult female 05day    1131 adult female 30day    1289 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1274) embryo 02-04hr  (480) embryo 04-06hr  (663) embryo 06-08hr  (988) embryo 08-10hr  (1029) embryo 10-12hr  (1044) embryo 12-14hr  (652) embryo 14-16hr  (785) embryo 16-18hr  (647) embryo 18-20hr  (599) embryo 20-22hr  (611) embryo 22-24hr  (626) larva L1  (778) larva L2  (675) larva L3 12hr old  (758) larva L3 puffstage 1-2  (1912) larva L3 puffstage 3-6  (1882) larva L3 puffstage 7-9  (1655) white prepupae new  (1368) white prepupae 12hr  (1392) white prepupae 24hr  (1240) pupae 2d postWPP  (955) pupae 3d postWPP  (698) pupae 4d postWPP  (765) adult male 01day  (1196) adult male 05day  (1500) adult male 30day  (1724) adult female 01day  (1394) adult female 05day  (1131) adult female 30day  (1289) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1274 embryo 02-04hr    480 embryo 04-06hr    663 embryo 06-08hr    988 embryo 08-10hr    1029 embryo 10-12hr    1044 embryo 12-14hr    652 embryo 14-16hr    785 embryo 16-18hr    647 embryo 18-20hr    599 embryo 20-22hr    611 embryo 22-24hr    626 larva L1    778 larva L2    675 larva L3 12hr old    758 larva L3 puffstage 1-2  (1912) larva L3 puffstage 3-6  (1882) larva L3 puffstage 7-9  (1655) white prepupae new    1368 white prepupae 12hr    1392 white prepupae 24hr    1240 pupae 2d postWPP    955 pupae 3d postWPP    698 pupae 4d postWPP    765 adult male 01day    1196 adult male 05day  1500 adult male 30day  (1724) adult female 01day    1394 adult female 05day    1131 adult female 30day    1289 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1274 embryo 02-04hr    480 embryo 04-06hr    663 embryo 06-08hr    988 embryo 08-10hr    1029 embryo 10-12hr    1044 embryo 12-14hr    652 embryo 14-16hr    785 embryo 16-18hr    647 embryo 18-20hr    599 embryo 20-22hr    611 embryo 22-24hr    626 larva L1    778 larva L2    675 larva L3 12hr old    758 larva L3 puffstage 1-2    1912 larva L3 puffstage 3-6    1882 larva L3 puffstage 7-9    1655 white prepupae new    1368 white prepupae 12hr    1392 white prepupae 24hr    1240 pupae 2d postWPP    955 pupae 3d postWPP    698 pupae 4d postWPP    765 adult male 01day    1196 adult male 05day    1500 adult male 30day    1724 adult female 01day    1394 adult female 05day    1131 adult female 30day    1289 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1274 embryo 02-04hr    480 embryo 04-06hr    663 embryo 06-08hr    988 embryo 08-10hr    1029 embryo 10-12hr    1044 embryo 12-14hr    652 embryo 14-16hr    785 embryo 16-18hr    647 embryo 18-20hr    599 embryo 20-22hr    611 embryo 22-24hr    626 larva L1    778 larva L2    675 larva L3 12hr old    758 larva L3 puffstage 1-2    1912 larva L3 puffstage 3-6    1882 larva L3 puffstage 7-9    1655 white prepupae new    1368 white prepupae 12hr    1392 white prepupae 24hr    1240 pupae 2d postWPP    955 pupae 3d postWPP    698 pupae 4d postWPP    765 adult male 01day    1196 adult male 05day    1500 adult male 30day    1724 adult female 01day    1394 adult female 05day    1131 adult female 30day    1289 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0025624 expression level Developmental Stage   Expression Level embryo 00-02hr    1274 embryo 02-04hr    480 embryo 04-06hr    663 embryo 06-08hr    988 embryo 08-10hr    1029 embryo 10-12hr    1044 embryo 12-14hr    652 embryo 14-16hr    785 embryo 16-18hr    647 embryo 18-20hr    599 embryo 20-22hr    611 embryo 22-24hr    626 larva L1    778 larva L2    675 larva L3 12hr old    758 larva L3 puffstage 1-2    1912 larva L3 puffstage 3-6    1882 larva L3 puffstage 7-9    1655 white prepupae new    1368 white prepupae 12hr    1392 white prepupae 24hr    1240 pupae 2d postWPP    955 pupae 3d postWPP    698 pupae 4d postWPP    765 adult male 01day    1196 adult male 05day    1500 adult male 30day    1724 adult female 01day    1394 adult female 05day    1131 adult female 30day    1289 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1274) embryo 02-04hr  (480) embryo 04-06hr  (663) embryo 06-08hr  (988) embryo 08-10hr  (1029) embryo 10-12hr  (1044) embryo 12-14hr  (652) embryo 14-16hr  (785) embryo 16-18hr  (647) embryo 18-20hr  (599) embryo 20-22hr  (611) embryo 22-24hr  (626) larva L1  (778) larva L2  (675) larva L3 12hr old  (758) larva L3 puffstage 1-2  (1912) larva L3 puffstage 3-6  (1882) larva L3 puffstage 7-9  (1655) white prepupae new  (1368) white prepupae 12hr  (1392) white prepupae 24hr  (1240) pupae 2d postWPP  (955) pupae 3d postWPP  (698) pupae 4d postWPP  (765) adult male 01day  (1196) adult male 05day  (1500) adult male 30day  (1724) adult female 01day  (1394) adult female 05day  (1131) adult female 30day  (1289) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1274 embryo 02-04hr    480 embryo 04-06hr    663 embryo 06-08hr    988 embryo 08-10hr    1029 embryo 10-12hr    1044 embryo 12-14hr    652 embryo 14-16hr    785 embryo 16-18hr    647 embryo 18-20hr    599 embryo 20-22hr    611 embryo 22-24hr    626 larva L1    778 larva L2    675 larva L3 12hr old    758 larva L3 puffstage 1-2  1912 larva L3 puffstage 3-6  1882 larva L3 puffstage 7-9  1655 white prepupae new    1368 white prepupae 12hr    1392 white prepupae 24hr    1240 pupae 2d postWPP    955 pupae 3d postWPP    698 pupae 4d postWPP    765 adult male 01day    1196 adult male 05day  1500 adult male 30day  1724 adult female 01day    1394 adult female 05day    1131 adult female 30day    1289 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1274 embryo 02-04hr    480 embryo 04-06hr    663 embryo 06-08hr    988 embryo 08-10hr    1029 embryo 10-12hr    1044 embryo 12-14hr    652 embryo 14-16hr    785 embryo 16-18hr    647 embryo 18-20hr    599 embryo 20-22hr    611 embryo 22-24hr    626 larva L1    778 larva L2    675 larva L3 12hr old    758 larva L3 puffstage 1-2    1912 larva L3 puffstage 3-6    1882 larva L3 puffstage 7-9    1655 white prepupae new    1368 white prepupae 12hr    1392 white prepupae 24hr    1240 pupae 2d postWPP    955 pupae 3d postWPP    698 pupae 4d postWPP    765 adult male 01day    1196 adult male 05day    1500 adult male 30day    1724 adult female 01day    1394 adult female 05day    1131 adult female 30day    1289 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1274 embryo 02-04hr    480 embryo 04-06hr    663 embryo 06-08hr    988 embryo 08-10hr    1029 embryo 10-12hr    1044 embryo 12-14hr    652 embryo 14-16hr    785 embryo 16-18hr    647 embryo 18-20hr    599 embryo 20-22hr    611 embryo 22-24hr    626 larva L1    778 larva L2    675 larva L3 12hr old    758 larva L3 puffstage 1-2    1912 larva L3 puffstage 3-6    1882 larva L3 puffstage 7-9    1655 white prepupae new    1368 white prepupae 12hr    1392 white prepupae 24hr    1240 pupae 2d postWPP    955 pupae 3d postWPP    698 pupae 4d postWPP    765 adult male 01day    1196 adult male 05day    1500 adult male 30day    1724 adult female 01day    1394 adult female 05day    1131 adult female 30day    1289 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0025624    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0025624 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult brain, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0025624 expression level Tissue   Expression Level Larval Central Nervous System    63.4 Larval Midgut    251.3 Larval Hindgut    169.7 Larval Malpighian Tubules    220.2 Larval Fat Body    124 Larval Salivary Gland    116.8 Larval Trachea    172.425 Larval Carcass    113 Adult Head    126.5 Adult Eye    184.65 Adult Brain    131.9 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    114.8 Adult Midgut    254 Adult Hindgut    209.5 Adult Malpighian Tubules    164.4 Adult Fat Body    143.3 Adult Salivary Gland    127.4 Adult Heart    157.65 Adult VirginFemale Spermatheca    158.1 Adult InseminatedFemale Spermatheca    126.1 Adult Ovary    45.2 Adult Testis    19 Adult Male Accessory Gland    202.8 Adult Carcass    116 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    63.4 Larval Midgut    251.3 Larval Hindgut    169.7 Larval Malpighian Tubules    220.2 Larval Fat Body    124 Larval Salivary Gland    116.8 Larval Trachea    172.425 Larval Carcass    113 Adult Head    126.5 Adult Eye    184.65 Adult Brain    131.9 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    114.8 Adult Midgut    254 Adult Hindgut    209.5 Adult Malpighian Tubules    164.4 Adult Fat Body    143.3 Adult Salivary Gland    127.4 Adult Heart    157.65 Adult VirginFemale Spermatheca    158.1 Adult InseminatedFemale Spermatheca    126.1 Adult Ovary    45.2 Adult Testis    19 Adult Male Accessory Gland    202.8 Adult Carcass    116 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    63.4 Larval Midgut    251.3 Larval Hindgut    169.7 Larval Malpighian Tubules    220.2 Larval Fat Body    124 Larval Salivary Gland    116.8 Larval Trachea    172.425 Larval Carcass    113 Adult Head    126.5 Adult Eye    184.65 Adult Brain    131.9 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    114.8 Adult Midgut    254 Adult Hindgut    209.5 Adult Malpighian Tubules    164.4 Adult Fat Body    143.3 Adult Salivary Gland    127.4 Adult Heart    157.65 Adult VirginFemale Spermatheca    158.1 Adult InseminatedFemale Spermatheca    126.1 Adult Ovary    45.2 Adult Testis    19 Adult Male Accessory Gland    202.8 Adult Carcass    116 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    63.4 Larval Midgut    251.3 Larval Hindgut    169.7 Larval Malpighian Tubules    220.2 Larval Fat Body    124 Larval Salivary Gland    116.8 Larval Trachea    172.425 Larval Carcass    113 Adult Head    126.5 Adult Eye    184.65 Adult Brain    131.9 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    114.8 Adult Midgut    254 Adult Hindgut    209.5 Adult Malpighian Tubules    164.4 Adult Fat Body    143.3 Adult Salivary Gland    127.4 Adult Heart    157.65 Adult VirginFemale Spermatheca    158.1 Adult InseminatedFemale Spermatheca    126.1 Adult Ovary    45.2 Adult Testis    19 Adult Male Accessory Gland    202.8 Adult Carcass    116 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0025624 expression level Tissue   Expression Level Larval Central Nervous System    63.4 Larval Midgut    251.3 Larval Hindgut    169.7 Larval Malpighian Tubules    220.2 Larval Fat Body    124 Larval Salivary Gland    116.8 Larval Trachea    172.425 Larval Carcass    113 Adult Head    126.5 Adult Eye    184.65 Adult Brain    131.9 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    114.8 Adult Midgut    254 Adult Hindgut    209.5 Adult Malpighian Tubules    164.4 Adult Fat Body    143.3 Adult Salivary Gland    127.4 Adult Heart    157.65 Adult VirginFemale Spermatheca    158.1 Adult InseminatedFemale Spermatheca    126.1 Adult Ovary    45.2 Adult Testis    19 Adult Male Accessory Gland    202.8 Adult Carcass    116 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    63.4 Larval Midgut    251.3 Larval Hindgut    169.7 Larval Malpighian Tubules    220.2 Larval Fat Body    124 Larval Salivary Gland    116.8 Larval Trachea    172.425 Larval Carcass    113 Adult Head    126.5 Adult Eye    184.65 Adult Brain    131.9 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    114.8 Adult Midgut    254 Adult Hindgut    209.5 Adult Malpighian Tubules    164.4 Adult Fat Body    143.3 Adult Salivary Gland    127.4 Adult Heart    157.65 Adult VirginFemale Spermatheca    158.1 Adult InseminatedFemale Spermatheca    126.1 Adult Ovary    45.2 Adult Testis    19 Adult Male Accessory Gland    202.8 Adult Carcass    116 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    63.4 Larval Midgut    251.3 Larval Hindgut    169.7 Larval Malpighian Tubules    220.2 Larval Fat Body    124 Larval Salivary Gland    116.8 Larval Trachea    172.425 Larval Carcass    113 Adult Head    126.5 Adult Eye    184.65 Adult Brain    131.9 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    114.8 Adult Midgut    254 Adult Hindgut    209.5 Adult Malpighian Tubules    164.4 Adult Fat Body    143.3 Adult Salivary Gland    127.4 Adult Heart    157.65 Adult VirginFemale Spermatheca    158.1 Adult InseminatedFemale Spermatheca    126.1 Adult Ovary    45.2 Adult Testis    19 Adult Male Accessory Gland    202.8 Adult Carcass    116 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    63.4 Larval Midgut    251.3 Larval Hindgut    169.7 Larval Malpighian Tubules    220.2 Larval Fat Body    124 Larval Salivary Gland    116.8 Larval Trachea    172.425 Larval Carcass    113 Adult Head    126.5 Adult Eye    184.65 Adult Brain    131.9 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    114.8 Adult Midgut    254 Adult Hindgut    209.5 Adult Malpighian Tubules    164.4 Adult Fat Body    143.3 Adult Salivary Gland    127.4 Adult Heart    157.65 Adult VirginFemale Spermatheca    158.1 Adult InseminatedFemale Spermatheca    126.1 Adult Ovary    45.2 Adult Testis    19 Adult Male Accessory Gland    202.8 Adult Carcass    116 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    126.5   NA  Eye    184.65   NA  Brain    131.9   63.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    87.3   NA  Crop    114.8   251.3  Midgut    254   169.7  Hindgut    209.5   220.2  Malpighian Tubules    164.4   124  Fat Body    143.3   116.8  Salivary Gland    127.4   NA  Heart    157.65   172.425  Trachea    NA   NA  VirginFemale Spermatheca    158.1   NA  InseminatedFemale Spermatheca    126.1   NA  Ovary    45.2   NA  Testis    19   NA  Male Accessory Gland    202.8   113  Carcass    116 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025624 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4025-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG4025GD3197 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG4025 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG4025 Class Mutagen Stocks Known lesion CG4025GD3197 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG4025KK107478 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6289 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3197} NA P{KK107478} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG4025 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57721 DroID - A comprehensive database of gene and protein interactions. • FBgn0025624 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31177
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21936 Dere\GG12904 Dgri\GH24452 Dmoj\GI21652 Dper\GL18336 Dpse\GA17883 Dsec\GM19194 Dsim\GD16585 Dvir\GJ16890 Dwil\GK10247 Dyak\GE16232
Curated drosophilid orthologs	Dpse\GA17883   Dyak\GE11018
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008408-PA Aedes aegypti (mosquito) AGAP000808-PA Anopheles gambiae (mosquito) 125861 Branchiostoma floridae (lancelet) XP_001896911.1 Brugia malayi (roundworm nematode) ENSBTAP00000052570 Bos taurus (bovine) CN16695 Caenorhabditis brenneri (small nematode) CBP07721 Caenorhabditis briggsae (nematode) CE08547 Caenorhabditis elegans (worm) ENSCAFP00000029258 Canis familiaris (dog) ENSCINP00000027559 Ciona intestinalis (sea squirt) JA10260 Caenorhabditis japonica (nematode) CPIJ012563 Culex pipens (mosquito) ENSCPOP00000003160 Cavia porcellus (guinea pig) RP09639 Caenorhabditis remanei (nematode) ENSCSAVP00000012850 Ciona savignyi (sedentary tunicate) 183312 Capitella spl (polychaete worm) DDB0302450 Dictyostelium discoideum (amoeba) ENSDARP00000096675 Danio rerio (zebra fish) ENSECAP00000009135 Equus caballus (horse) ENSGACP00000005436 Gymnopilus aculeatus (mushroom) ENSGALP00000020794 Gallus gallus (chicken) ENSP00000286692 Homo sapiens (human) ISCW009192-PA Ixodes scapularis (deer tick) 217334 Lottia gigantea (owl limpet) ENSMODP00000001887 Monodelphis domestica (gray opossum) ENSMMUP00000003315 Macaca mulatta (rhesus monkey) ENSMUSP00000020249 Mus musculus (house mouse) 123078 Nematostella vectensis (starlet anemone) ENSOANP00000022484 Ornithorynchus anatinus (platypus) ENSORLP00000019610 Oryzias latipes (japanese killifish) PHUM006736-PA Pediculus humanus (human body louse) PP11162 Pristionchus pacificus (nematode) ENSPPYP00000001210 Pongo pygmaeus (orangutan) ENSPTRP00000001883 Pan troglodytes (chimpanzee) ENSRNOP00000023903 Rattus norvegicus (norway rat) Smp_006760 Schistosoma mansoni (trematode parasite) 63626 Trichoplax adhaerens (metazoa) XP_973983.1 Tribolium castaneum (red flour beetle) ENSTNIP00000004781 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000019759 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000009867 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH24051 ISCW009192 FBgn0233772 FBgn0068319 FBgn0212262 FBgn0204069 FBgn0188189 FBgn0174096 FBgn0077892 FBgn0155937 FBgn0144382 FBgn0131908 FBgn0105177 FBgn0098936 CPIJ012563 GB11645 AGAP000808 AAEL008408 PB25142 GLEAN_00828 GLEAN_00745
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v100288 P{KK107478}VIE-260B v6924 w1118; P{GD3197}v6924
Genomic Clones ( 1 )
	BACR32O19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP10820
Other clones	yak-ad_EG
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01581 SD08622 SD20054 SD22251
Other clones	11223 51147 106665 214221.49 528185 568901 CK01.56B.B12 EK045440 EK111649 EK161915 EN09017 EN13003 EN14142 EP03153 RC0-DA0009-130700-012-F06
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025624 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31177
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG4025 anon-WO0140519.169 (FlyBase, 1996-)
Additional comments	Source for merge of CG4025 anon-WO0140519.169 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_130623 RefSeq (Proteins) • NP_569979 DDBJ / EMBL / GenBank • AAF45721 AAM49982 AI296752 AL031765 AX154820 AY118613 CAA21131 Entrez Gene - A searchable database of RefSeq genes. • 31177 UniProtKB/TrEMBL • O77262
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Frag1/DRAM/Sfk1 (IPR019402)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57721 DroID - A comprehensive database of gene and protein interactions. • FBgn0025624 DRSC - Results from RNAi screens. • FBgn0025624 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025624 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4025-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025624 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31177 InParanoid A subset of ortholog calls from InParanoid. • AAEL008408-PA Aedes aegypti (mosquito) AGAP000808-PA Anopheles gambiae (mosquito) 125861 Branchiostoma floridae (lancelet) XP_001896911.1 Brugia malayi (roundworm nematode) ENSBTAP00000052570 Bos taurus (bovine) CN16695 Caenorhabditis brenneri (small nematode) CBP07721 Caenorhabditis briggsae (nematode) CE08547 Caenorhabditis elegans (worm) ENSCAFP00000029258 Canis familiaris (dog) ENSCINP00000027559 Ciona intestinalis (sea squirt) JA10260 Caenorhabditis japonica (nematode) CPIJ012563 Culex pipens (mosquito) ENSCPOP00000003160 Cavia porcellus (guinea pig) RP09639 Caenorhabditis remanei (nematode) ENSCSAVP00000012850 Ciona savignyi (sedentary tunicate) 183312 Capitella spl (polychaete worm) DDB0302450 Dictyostelium discoideum (amoeba) ENSDARP00000096675 Danio rerio (zebra fish) ENSECAP00000009135 Equus caballus (horse) ENSGACP00000005436 Gymnopilus aculeatus (mushroom) ENSGALP00000020794 Gallus gallus (chicken) ENSP00000286692 Homo sapiens (human) ISCW009192-PA Ixodes scapularis (deer tick) 217334 Lottia gigantea (owl limpet) ENSMODP00000001887 Monodelphis domestica (gray opossum) ENSMMUP00000003315 Macaca mulatta (rhesus monkey) ENSMUSP00000020249 Mus musculus (house mouse) 123078 Nematostella vectensis (starlet anemone) ENSOANP00000022484 Ornithorynchus anatinus (platypus) ENSORLP00000019610 Oryzias latipes (japanese killifish) PHUM006736-PA Pediculus humanus (human body louse) PP11162 Pristionchus pacificus (nematode) ENSPPYP00000001210 Pongo pygmaeus (orangutan) ENSPTRP00000001883 Pan troglodytes (chimpanzee) ENSRNOP00000023903 Rattus norvegicus (norway rat) Smp_006760 Schistosoma mansoni (trematode parasite) 63626 Trichoplax adhaerens (metazoa) XP_973983.1 Tribolium castaneum (red flour beetle) ENSTNIP00000004781 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000019759 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000009867 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31177 modMine - Data generated by the modENCODE project. • FBgn0025624 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH24051 ISCW009192 FBgn0233772 FBgn0068319 FBgn0212262 FBgn0204069 FBgn0188189 FBgn0174096 FBgn0077892 FBgn0155937 FBgn0144382 FBgn0131908 FBgn0105177 FBgn0098936 CPIJ012563 GB11645 AGAP000808 AAEL008408 PB25142 GLEAN_00828 GLEAN_00745
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	anon-WO0140519.169   CG4025 (Keleman et al., 2009.8.5) EG:22E5.9 (Zinke et al., 2002, Benos et al., 2001, Giot et al., 2003, )
Name Synonym
Secondary FlyBase IDs
	FBgn0044709
References ( 13 )
Research paper	Beisswanger et al., 2006, Genetics 172(1): 265--274 Evidence for a selective sweep in the wapl region of Drosophila melanogaster. [FBrf0190705] Zinke et al., 2002, EMBO J. 21(22): 6162--6173 Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. [FBrf0151960] Benos et al., 2001, Genome Res. 11(5): 710--730 From First Base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. [FBrf0135823]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Benos, 2000.12.13, FlyBase error report on Wed Dec 13 14:35:56 2000. FlyBase error report on Wed Dec 13 14:35:56 2000. [FBrf0133222]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Patent	Greenspan, 2001.6.7, World Patent 0140519-A: Methods for identifying modulators for balance related disorders. [FBrf0141245]