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Gene Dmel\DAAM

General Information
Symbol	Dmel\DAAM	Species	D. melanogaster
Name	Dishevelled Associated Activator of Morphogenesis	Annotation symbol	CG14622
Feature type	protein_coding_gene	FlyBase ID	FBgn0025641
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	EG:114D9.2, dDAAM
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	1F2-1F3	Sequence location	X:1,183,746..1,216,427 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dishevelled Associated Activator of Morphogenesis is referred to in FlyBase by the symbol Dmel\DAAM (CG14622, FBgn0025641). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence that it is involved in the biological process: actin filament bundle assembly; regulation of axonogenesis; positive regulation of filopodium assembly; regulation of filopodium assembly; regulation of tube architecture, open tracheal system; open tracheal system development. 26 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; anatomical structure; organ system subdivision; tracheal system; cell part; portion of tissue; cell projection; acellular anatomical structure; organelle. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Actin-binding FH2; Actin-binding FH2/DRF autoregulatory; Armadillo-type fold; Diaphanous FH3; Diaphanous GTPase-binding; Diaphanous autoregulatory; GTPase-binding/formin homology 3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult brain, larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1629015_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of DAAM. Gene sequence location is X:1183746..1216427.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Polypeptides DAAM-PG Transcripts DAAM-RG
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 1F2-1F3   Limits computationally determined from genome sequence between P{EP}EP1542 and P{EP}futschEP1419
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\DAAM for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene model reviewed during 5.43 Gene model reviewed during 5.51 Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) DAAM-RA FBtr0070241  NM_130544   4274   1114 DAAM-RB FBtr0070239  NM_166876   5397   1153 DAAM-RD FBtr0303264  NM_001201593   5470   1463 DAAM-RE FBtr0310282  NM_001272197   5414   1153 DAAM-RF FBtr0310283  NM_166875   5157   1153 DAAM-RG FBtr0342731     5355   1153
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein DAAM-PA   FBpp0070231   125.5   1114   6.97     NP_569900   AAF45600 DAAM-PB   FBpp0070229   129.9   1153   6.90     NP_726724   AAN09040 DAAM-PD   FBpp0292356   162.3   1463   6.81     NP_001188522   ADV37606 DAAM-PE   FBpp0301965   129.9   1153   6.90     NP_001259126   AGB94972 DAAM-PF   FBpp0301966   129.9   1153   6.90     NP_726723   AAF45601 DAAM-PG   FBpp0309599   129.9   1153   6.90
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Actin-binding FH2/DRF autoregulatory (IPR003104) Diaphanous FH3 (IPR010472) GTPase-binding/formin homology 3 (IPR014768) Actin-binding FH2 (IPR015425) Diaphanous autoregulatory (IPR014767) Diaphanous GTPase-binding (IPR010473) Armadillo-type fold (IPR016024)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA942048   AE014298 AAF45600   AE014298 AAF45601   AE014298 AAN09040   AE014298 ADV37606   AF171816   AE014298 AGB94972   AL031640 CAA21052   AY118439 AAM48468   BI484790   BI623629   BI631718   BT021242 AAX33390   CO263834   CO271851   CO277094   CO324646   CO329617   CZ479464   CZ482270   CZ482271   CZ488700   CZ489112   CZ489113   EC052018   EC066602   EC083144   EC083634   EC223809   EC232730   EC250671   EL881180   EL881181   GH945501   GH953259   GH959388   GH964618   GH976377
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7YZA4 Q8IRY0 Q9W5A4 Q7KW17 Q8MT16 Q5BII2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) embryonic leading edge cell primordium   (Fisher et al., 2012) Comment:reported as embryonic leading edge cell specific anlage head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic esophagus   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic leading edge cell   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
axonal growth cone inferred from direct assay (Matusek et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult brain, larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    477.925 Larval Midgut    35.2 Larval Hindgut    67.9 Larval Malpighian Tubules    1266.6 Larval Fat Body    20.4 Larval Salivary Gland    10.9 Larval Trachea    43.5 Larval Carcass    49.825 Adult Head    404.3 Adult Eye    1000.325 Adult Brain    796.5 Adult Thoracic-Abdominal Ganglion    421.3 Adult Crop    14.8 Adult Midgut    9.1 Adult Hindgut    24 Adult Malpighian Tubules    957.2 Adult Fat Body    33.1 Adult Salivary Gland    6.4 Adult Heart    38.45 Adult VirginFemale Spermatheca    8 Adult InseminatedFemale Spermatheca    7 Adult Ovary    371.3 Adult Testis    48.8 Adult Male Accessory Gland    10.1 Adult Carcass    42.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    477.925 Larval Midgut    35.2 Larval Hindgut    67.9 Larval Malpighian Tubules  (1266.6) Larval Fat Body    20.4 Larval Salivary Gland    10.9 Larval Trachea    43.5 Larval Carcass    49.825 Adult Head    404.3 Adult Eye  (1000.325) Adult Brain  (796.5) Adult Thoracic-Abdominal Ganglion    421.3 Adult Crop    14.8 Adult Midgut    9.1 Adult Hindgut    24 Adult Malpighian Tubules  (957.2) Adult Fat Body    33.1 Adult Salivary Gland    6.4 Adult Heart    38.45 Adult VirginFemale Spermatheca    8 Adult InseminatedFemale Spermatheca    7 Adult Ovary    371.3 Adult Testis    48.8 Adult Male Accessory Gland    10.1 Adult Carcass    42.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    477.925 Larval Midgut    35.2 Larval Hindgut    67.9 Larval Malpighian Tubules  (1266.6) Larval Fat Body    20.4 Larval Salivary Gland    10.9 Larval Trachea    43.5 Larval Carcass    49.825 Adult Head    404.3 Adult Eye  1000.325 Adult Brain    796.5 Adult Thoracic-Abdominal Ganglion    421.3 Adult Crop    14.8 Adult Midgut    9.1 Adult Hindgut    24 Adult Malpighian Tubules    957.2 Adult Fat Body    33.1 Adult Salivary Gland    6.4 Adult Heart    38.45 Adult VirginFemale Spermatheca    8 Adult InseminatedFemale Spermatheca    7 Adult Ovary    371.3 Adult Testis    48.8 Adult Male Accessory Gland    10.1 Adult Carcass    42.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    477.925 Larval Midgut    35.2 Larval Hindgut    67.9 Larval Malpighian Tubules    1266.6 Larval Fat Body    20.4 Larval Salivary Gland    10.9 Larval Trachea    43.5 Larval Carcass    49.825 Adult Head    404.3 Adult Eye    1000.325 Adult Brain    796.5 Adult Thoracic-Abdominal Ganglion    421.3 Adult Crop    14.8 Adult Midgut    9.1 Adult Hindgut    24 Adult Malpighian Tubules    957.2 Adult Fat Body    33.1 Adult Salivary Gland    6.4 Adult Heart    38.45 Adult VirginFemale Spermatheca    8 Adult InseminatedFemale Spermatheca    7 Adult Ovary    371.3 Adult Testis    48.8 Adult Male Accessory Gland    10.1 Adult Carcass    42.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    477.925 Larval Midgut    35.2 Larval Hindgut    67.9 Larval Malpighian Tubules    1266.6 Larval Fat Body    20.4 Larval Salivary Gland    10.9 Larval Trachea    43.5 Larval Carcass    49.825 Adult Head    404.3 Adult Eye    1000.325 Adult Brain    796.5 Adult Thoracic-Abdominal Ganglion    421.3 Adult Crop    14.8 Adult Midgut    9.1 Adult Hindgut    24 Adult Malpighian Tubules    957.2 Adult Fat Body    33.1 Adult Salivary Gland    6.4 Adult Heart    38.45 Adult VirginFemale Spermatheca    8 Adult InseminatedFemale Spermatheca    7 Adult Ovary    371.3 Adult Testis    48.8 Adult Male Accessory Gland    10.1 Adult Carcass    42.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    477.925 Larval Midgut    35.2 Larval Hindgut    67.9 Larval Malpighian Tubules  (1266.6) Larval Fat Body    20.4 Larval Salivary Gland    10.9 Larval Trachea    43.5 Larval Carcass    49.825 Adult Head    404.3 Adult Eye  (1000.325) Adult Brain  796.5 Adult Thoracic-Abdominal Ganglion    421.3 Adult Crop    14.8 Adult Midgut    9.1 Adult Hindgut    24 Adult Malpighian Tubules  (957.2) Adult Fat Body    33.1 Adult Salivary Gland    6.4 Adult Heart    38.45 Adult VirginFemale Spermatheca    8 Adult InseminatedFemale Spermatheca    7 Adult Ovary    371.3 Adult Testis    48.8 Adult Male Accessory Gland    10.1 Adult Carcass    42.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    477.925 Larval Midgut    35.2 Larval Hindgut    67.9 Larval Malpighian Tubules  1266.6 Larval Fat Body    20.4 Larval Salivary Gland    10.9 Larval Trachea    43.5 Larval Carcass    49.825 Adult Head    404.3 Adult Eye  1000.325 Adult Brain    796.5 Adult Thoracic-Abdominal Ganglion    421.3 Adult Crop    14.8 Adult Midgut    9.1 Adult Hindgut    24 Adult Malpighian Tubules    957.2 Adult Fat Body    33.1 Adult Salivary Gland    6.4 Adult Heart    38.45 Adult VirginFemale Spermatheca    8 Adult InseminatedFemale Spermatheca    7 Adult Ovary    371.3 Adult Testis    48.8 Adult Male Accessory Gland    10.1 Adult Carcass    42.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    477.925 Larval Midgut    35.2 Larval Hindgut    67.9 Larval Malpighian Tubules    1266.6 Larval Fat Body    20.4 Larval Salivary Gland    10.9 Larval Trachea    43.5 Larval Carcass    49.825 Adult Head    404.3 Adult Eye    1000.325 Adult Brain    796.5 Adult Thoracic-Abdominal Ganglion    421.3 Adult Crop    14.8 Adult Midgut    9.1 Adult Hindgut    24 Adult Malpighian Tubules    957.2 Adult Fat Body    33.1 Adult Salivary Gland    6.4 Adult Heart    38.45 Adult VirginFemale Spermatheca    8 Adult InseminatedFemale Spermatheca    7 Adult Ovary    371.3 Adult Testis    48.8 Adult Male Accessory Gland    10.1 Adult Carcass    42.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    404.3   NA  Eye    1000.325   NA  Brain    796.5   477.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    421.3   NA  Crop    14.8   35.2  Midgut    9.1   67.9  Hindgut    24   1266.6  Malpighian Tubules    957.2   20.4  Fat Body    33.1   no informative data  Salivary Gland    6.4   NA  Heart    38.45   43.5  Trachea    NA   NA  VirginFemale Spermatheca    8   NA  InseminatedFemale Spermatheca    7   NA  Ovary    371.3   NA  Testis    48.8   NA  Male Accessory Gland    no informative data   49.825  Carcass    42.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    26 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    37 ovary, mated 4-day female    33 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3  26 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female  (37) ovary, mated 4-day female  (33) testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    26 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    37 ovary, mated 4-day female    33 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    26 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    37 ovary, mated 4-day female    33 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    26 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    37 ovary, mated 4-day female    33 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3  26 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female  (37) ovary, mated 4-day female  (33) testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    26 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    37 ovary, mated 4-day female    33 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    26 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    13 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    20 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    37 ovary, mated 4-day female    33 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    50 embryo 02-04hr    47 embryo 04-06hr    15 embryo 06-08hr    18 embryo 08-10hr    23 embryo 10-12hr    19 embryo 12-14hr    23 embryo 14-16hr    63 embryo 16-18hr    27 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    16 larva L1    8 larva L2    21 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    14 white prepupae 24hr    13 pupae 2d postWPP    32 pupae 3d postWPP    16 pupae 4d postWPP    20 adult male 01day    12 adult male 05day    12 adult male 30day    12 adult female 01day    20 adult female 05day    24 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (50) embryo 02-04hr  (47) embryo 04-06hr    15 embryo 06-08hr    18 embryo 08-10hr    23 embryo 10-12hr    19 embryo 12-14hr    23 embryo 14-16hr  (63) embryo 16-18hr  (27) embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    16 larva L1    8 larva L2    21 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    14 white prepupae 24hr    13 pupae 2d postWPP  (32) pupae 3d postWPP    16 pupae 4d postWPP    20 adult male 01day    12 adult male 05day    12 adult male 30day    12 adult female 01day    20 adult female 05day    24 adult female 30day  (28) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    50 embryo 02-04hr    47 embryo 04-06hr    15 embryo 06-08hr    18 embryo 08-10hr    23 embryo 10-12hr    19 embryo 12-14hr    23 embryo 14-16hr    63 embryo 16-18hr    27 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    16 larva L1    8 larva L2    21 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    14 white prepupae 24hr    13 pupae 2d postWPP    32 pupae 3d postWPP    16 pupae 4d postWPP    20 adult male 01day    12 adult male 05day    12 adult male 30day    12 adult female 01day    20 adult female 05day    24 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    50 embryo 02-04hr    47 embryo 04-06hr    15 embryo 06-08hr    18 embryo 08-10hr    23 embryo 10-12hr    19 embryo 12-14hr    23 embryo 14-16hr    63 embryo 16-18hr    27 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    16 larva L1    8 larva L2    21 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    14 white prepupae 24hr    13 pupae 2d postWPP    32 pupae 3d postWPP    16 pupae 4d postWPP    20 adult male 01day    12 adult male 05day    12 adult male 30day    12 adult female 01day    20 adult female 05day    24 adult female 30day    28 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    50 embryo 02-04hr    47 embryo 04-06hr    15 embryo 06-08hr    18 embryo 08-10hr    23 embryo 10-12hr    19 embryo 12-14hr    23 embryo 14-16hr    63 embryo 16-18hr    27 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    16 larva L1    8 larva L2    21 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    14 white prepupae 24hr    13 pupae 2d postWPP    32 pupae 3d postWPP    16 pupae 4d postWPP    20 adult male 01day    12 adult male 05day    12 adult male 30day    12 adult female 01day    20 adult female 05day    24 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (50) embryo 02-04hr  (47) embryo 04-06hr    15 embryo 06-08hr    18 embryo 08-10hr    23 embryo 10-12hr    19 embryo 12-14hr    23 embryo 14-16hr  (63) embryo 16-18hr  27 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    16 larva L1    8 larva L2    21 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    14 white prepupae 24hr    13 pupae 2d postWPP  32 pupae 3d postWPP    16 pupae 4d postWPP    20 adult male 01day    12 adult male 05day    12 adult male 30day    12 adult female 01day    20 adult female 05day    24 adult female 30day  28 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    50 embryo 02-04hr    47 embryo 04-06hr    15 embryo 06-08hr    18 embryo 08-10hr    23 embryo 10-12hr    19 embryo 12-14hr    23 embryo 14-16hr    63 embryo 16-18hr    27 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    16 larva L1    8 larva L2    21 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    14 white prepupae 24hr    13 pupae 2d postWPP    32 pupae 3d postWPP    16 pupae 4d postWPP    20 adult male 01day    12 adult male 05day    12 adult male 30day    12 adult female 01day    20 adult female 05day    24 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    50 embryo 02-04hr    47 embryo 04-06hr    15 embryo 06-08hr    18 embryo 08-10hr    23 embryo 10-12hr    19 embryo 12-14hr    23 embryo 14-16hr    63 embryo 16-18hr    27 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    16 larva L1    8 larva L2    21 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    14 white prepupae 24hr    13 pupae 2d postWPP    32 pupae 3d postWPP    16 pupae 4d postWPP    20 adult male 01day    12 adult male 05day    12 adult male 30day    12 adult female 01day    20 adult female 05day    24 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    4 embryonic 1182-4H    16 embryonic GM2    1 embryonic Kc167    5 embryonic S1    19 embryonic S3    0 leg disc CME L1    4 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    13 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    4 embryonic 1182-4H    16 embryonic GM2    1 embryonic Kc167    5 embryonic S1    19 embryonic S3    0 leg disc CME L1    4 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    13 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    4 embryonic 1182-4H    16 embryonic GM2    1 embryonic Kc167    5 embryonic S1    19 embryonic S3    0 leg disc CME L1    4 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    13 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    4 embryonic 1182-4H    16 embryonic GM2    1 embryonic Kc167    5 embryonic S1    19 embryonic S3    0 leg disc CME L1    4 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    13 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    4 embryonic 1182-4H    16 embryonic GM2    1 embryonic Kc167    5 embryonic S1    19 embryonic S3    0 leg disc CME L1    4 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    13 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    4 embryonic 1182-4H    16 embryonic GM2    1 embryonic Kc167    5 embryonic S1    19 embryonic S3    0 leg disc CME L1    4 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    13 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    4 embryonic 1182-4H    16 embryonic GM2    1 embryonic Kc167    5 embryonic S1    19 embryonic S3    0 leg disc CME L1    4 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    13 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    4 embryonic 1182-4H    16 embryonic GM2    1 embryonic Kc167    5 embryonic S1    19 embryonic S3    0 leg disc CME L1    4 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    13 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    15 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    15 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult  (27) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  (33) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    15 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    15 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    15 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    15 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult  27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  (33) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    15 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    15 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RH61354 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025641 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14622-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for DAAM Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with DAAMEx1) DAAMEx36 DAAMEx68 lethal (with DAAMEx36) DAAMEx1 DAAMEx65 DAAMEx68 DAAMEx184 DAAMEx202 DAAMEx249 lethal (with DAAMEx65) DAAMEx36 DAAMEx68 DAAMEx184 DAAMEx202 DAAMEx249 lethal (with DAAMEx68) DAAMEx1 DAAMEx36 DAAMEx65 DAAMEx184 DAAMEx202 DAAMEx249 lethal (with DAAMEx184) DAAMEx36 DAAMEx65 DAAMEx68 DAAMEx202 DAAMEx249 lethal (with DAAMEx202) DAAMEx36 DAAMEx65 DAAMEx68 DAAMEx184 DAAMEx249 lethal (with DAAMEx249) DAAMEx36 DAAMEx65 DAAMEx68 DAAMEx184 DAAMEx202 lethal | embryonic stage, with Scer\GAL4elav-C155 DAAMC.Scer\UAS.P\T lethal | larval stage, with Scer\GAL4btl.PS DAAMFH1-FH2.Scer\UAS.T:Avic\GFP-YFP.Venus lethal | recessive DAAMEx36 DAAMEx65 DAAMEx68 DAAMEx184 DAAMEx202 DAAMEx249 partially lethal - majority die DAAMEx1 viable, with Scer\GAL4btl.PS DAAMFH2.Scer\UAS.T:Hsap\MYC viable, with Scer\GAL4pnr-MD237 DAAMGD8382 viable (with DAAMEx1) DAAMEx65 DAAMEx184 DAAMEx202 DAAMEx249 viable (with DAAMEx65) DAAMEx1 viable (with DAAMEx184) DAAMEx1 viable (with DAAMEx202) DAAMEx1 viable (with DAAMEx249) DAAMEx1 Sterility Allele fertile DAAMEx1 Other Phenotypes Allele neuroanatomy defective DAAMEx68 neuroanatomy defective, with Scer\GAL4elav-C155 DAAMC.Scer\UAS.P\T DAAMDADm.Scer\UAS neuroanatomy defective, with Scer\GAL4sca-109-68 DAAMDADm.Scer\UAS.T:Avic\GFP-EGFP neuroanatomy defective (with DAAMEx1) DAAMEx68 neuroanatomy defective (with DAAMEx68) DAAMEx1 Phenotype manifest in Allele axon, with Scer\GAL4elav-C155 DAAMDADm.Scer\UAS commissure | embryonic stage, with Scer\GAL4elav-C155 DAAMC.Scer\UAS.P\T connective DAAMEx68 connective (with DAAMEx1) DAAMEx68 connective (with DAAMEx68) DAAMEx1 embryo DAAMEx68 embryo (with DAAMEx1) DAAMEx68 embryo (with DAAMEx68) DAAMEx1 embryonic/larval cuticle DAAMEx68 embryonic/larval trachea DAAMEx1 embryonic/larval tracheal system DAAMEx68 embryonic/larval tracheal system, with Scer\GAL4btl.PS DAAMFH1-FH2.Scer\UAS.T:Avic\GFP-YFP.Venus embryonic/larval tracheal system (with Df(1)AD11) DAAMEx68 fascicle DAAMEx68 fascicle (with DAAMEx1) DAAMEx68 fascicle (with DAAMEx68) DAAMEx1 fascicle | embryonic stage, with Scer\GAL4elav-C155 DAAMC.Scer\UAS.P\T filamentous actin DAAMEx68 filamentous actin & tracheal fusion cell, with DAAMC.Scer\UAS.P\T, Scer\GAL4btl.PS DAAMScer\UAS.P\T.cMa filamentous actin & tracheal fusion cell, with DAAMScer\UAS.P\T.cMa, Scer\GAL4btl.PS DAAMC.Scer\UAS.P\T filamentous actin & tracheal fusion cell, with Scer\GAL4btl.PS DAAMC.Scer\UAS.P\T filamentous actin & tracheolar cell, with Scer\GAL4btl.PS DAAMC.Scer\UAS.P\T filopodium (with DAAMEx1) DAAMEx68 filopodium (with DAAMEx68) DAAMEx1 lateral longitudinal fascicle DAAMEx68 lateral longitudinal fascicle (with DAAMEx1) DAAMEx68 lateral longitudinal fascicle (with DAAMEx68) DAAMEx1 neurite, with Scer\GAL4elav-C155 DAAMDADm.Scer\UAS neuropil DAAMEx68 neuropil (with DAAMEx1) DAAMEx68 neuropil (with DAAMEx68) DAAMEx1 neuropil | embryonic stage, with Scer\GAL4elav-C155 DAAMC.Scer\UAS.P\T taenidial fold DAAMEx68 taenidial fold, with Scer\GAL4btl.PS DAAMFH1-FH2.Scer\UAS.T:Avic\GFP-YFP.Venus ventral nerve cord, with Scer\GAL4elav-C155 DAAMDADm.Scer\UAS
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of DAAM Class Mutagen Stocks Known lesion DAAMe01658 piggyBac transposase 1 -- DAAMe04522 piggyBac transposase 1 -- DAAMf06061 piggyBac transposase 1 -- DAAMf06407 piggyBac transposase 1 -- DAAMG1567 P-element activity 1 -- DAAMMB03627 1 -- DAAMMI04569 1 -- DAAMEx184 P-element activity 0 Yes DAAMEx1 P-element activity 0 Yes DAAMEx202 P-element activity 0 Yes DAAMEx249 P-element activity 0 Yes DAAMEx36 P-element activity 0 Yes DAAMEx65 P-element activity 0 Yes DAAMEx68 loss of function allele P-element activity 0 Yes DAAMGG01323 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of DAAM Class Mutagen Stocks Known lesion DAAMGD8382 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DAAMHMS01978 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DAAMKK102786 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DAAMC.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes DAAMCA.Scer\UAS 0 -- DAAMDADm.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes DAAMDADm.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes DAAMFH1-FH2.Scer\UAS.T:Avic\GFP-YFP.Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes DAAMFH2.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes DAAMNIG.14622R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes DAAMScer\UAS.P\T.cMa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)AC7 (Matusek et al., 2006) Df(1)AD11 (Matusek et al., 2006) Df(1)sta (Matusek et al., 2006)
Duplicated in	Dp(1;3)sta (Matusek et al., 2006) Dp(1;Y)Sz280 (Matusek et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8382} NA P{KK102786} NA P{NIG.14622R} NA P{TRiP.HMS01978} NA P{UAS-DAAM.C} NA P{UAS-Daam.CA} NA P{UAS-DAAM.DADm} NA P{UAS-DAAM.DADm-eGFP} NA P{UAS-DAAM.FH1-FH2} NA P{UAS-DAAM.FH2} NA P{UAS-DAAM.FL.M} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}DAAMG1567 NA P{EP}EP1542 NA P{Mae-UAS.6.11}DAAMGG01323 NA miscellaneous insertions Mi{MIC}DAAMMI04569 NA PBac{RB}DAAMe01658 NA PBac{RB}DAAMe04522 NA PBac{WH}DAAMf06061 NA PBac{WH}DAAMf06407 NA insertion of enhancer trap P{lacW}l(1)G0302G0302 No insertion of enhancer trap binary system Mi{ET1}DAAMMB03627 No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin filament bundle assembly inferred from mutant phenotype (Matusek et al., 2006) open tracheal system development inferred from mutant phenotype (Matusek et al., 2006) positive regulation of filopodium assembly inferred from mutant phenotype (Gonçalves-Pimentel et al., 2011) regulation of axonogenesis inferred from direct assay (Matusek et al., 2008) regulation of filopodium assembly inferred from direct assay (Matusek et al., 2008) regulation of tube architecture, open tracheal system inferred from mutant phenotype (Matusek et al., 2006)
Cellular Component
CV term Evidence References
axonal growth cone inferred from direct assay (Matusek et al., 2008)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
actin binding inferred from electronic annotation with InterPro:IPR003104, InterPro:IPR010472, InterPro:IPR010473 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) Rho GTPase binding inferred from electronic annotation with InterPro:IPR010473 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
actin cytoskeleton organization non-traceable author statement (Matusek et al., 2005) cuticle pattern formation non-traceable author statement (Matusek et al., 2005)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions DAAM allele Gene References unspecified Btk29A (Matusek et al., 2006) Rho1 (Matusek et al., 2006) Src42A (Matusek et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57637 DroID - A comprehensive database of gene and protein interactions. • FBgn0025641 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31075
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69PBHQ Dipteran inclusive ortholog search EOG65DWXC Insect inclusive ortholog search EOG6WSV5K Arthropod inclusive ortholog search EOG63J9KR Metazoa inclusive ortholog search EOG6JB0RP
Orthologs in Drosophila Species (EOG69PBHQ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\DAAM     Drosophila sechellia   Dsec\GM18987     Drosophila erecta   Dere\GG12709 Y   Drosophila yakuba   Dyak\GE16535     Drosophila ananassae   Dana\GF22176 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13122 Y   Drosophila persimilis   Dper\GL14390 Y   Drosophila willistoni   Dwil\GK19910 Y   Drosophila virilis   Dvir\GJ15849 Y   Drosophila mojavensis   Dmoj\GI16449 Y   Drosophila grimshawi   Dgri\GH17880 Y
Orthologs in non-Drosophila Dipterans (EOG65DWXC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013920   Anopheles gambiae Malaria mosquito  Agam\AGAP003292   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002005   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002006
Orthologs in non-Dipteran Insects (EOG6WSV5K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB42894   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012784   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25461   Atta cephalotes Leafcutter ant  Acep\ACEP15006   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18782   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15969   Linepithema humile Argentine ant  Lhum\LH20179   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23668   Solenopsis invicta Red fire ant  Sinv\SINV11860   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002207   Bombyx mori Silkmoth  Bmor\BGIBMGA008436   Pediculus humanus Human body louse  Phum\PHUM230120   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07082
Orthologs in non-Insect Arthropods (EOG63J9KR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Dhrs4   Ixodes scapularis Deer tick  Isca\ISCW018883
Orthologs in non-Arthropod Metazoa (EOG6JB0RP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\daam-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025696gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020925gn   Danio rerio Zebrafish  Drer\daam1a   Danio rerio Zebrafish  Drer\daam2   Danio rerio Zebrafish  Drer\daam1b   Xenopus tropicalis Western clawed frog  Xtro\daam1   Gallus gallus Domestic chicken  Ggal\DAAM1   Gallus gallus Domestic chicken  Ggal\DAAM2   Mus musculus House mouse  Mmus\Daam2   Mus musculus House mouse  Mmus\Daam1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000023351   Rattus norvegicus Norway rat  Rnor\Daam1   Homo sapiens Human  Hsap\DAAM2   Homo sapiens Human  Hsap\DAAM1
Human Orthologs (2)
Gene OMIM HGNC Hsap\DAAM2     Hsap\DAAM1
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG12709 Drosophila ananassae Dana\GF22176 Drosophila pseudoobscura pseudoobscura Dpse\GA13122 Drosophila persimilis Dper\GL14390 Drosophila willistoni Dwil\GK19910 Drosophila virilis Dvir\GJ15849 Drosophila mojavensis Dmoj\GI16449 Drosophila grimshawi Dgri\GH17880
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	33546 P{EP}DAAMG1567 w* 24187 w1118 Mi{ET1}DAAMMB03627 38567 y1 Mi{MIC}DAAMMI04569 w1118/FM7h 39058 y1 sc* v1; P{TRiP.HMS01978}attP2
Harvard	- PBac{RB}DAAMe01658 - PBac{RB}DAAMe04522 - PBac{WH}DAAMf06061 - PBac{WH}DAAMf06407
VDRC	v103921 P{KK102786}VIE-260B v24885 w1118; P{GD8382}v24885
Genomic Clones ( 1 )
	BACR30G24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 23 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE67944 RH61354
Other clones	AF171816
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD26058 RH55943
Other clones	1694 15005 15171 66443 163093 190713 EC052018 EK104942 EK122934 EK136603 EK194436 EK293246 IP10982 RP004132483 RP004230317 RP004321140 RP004501630 RP004559921
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025641 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31075
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: DAAM CG14622 (Matusek, 2005.9.6)
Source for database merge of
Additional comments	"l(1)G0302" may affect "CG14622". (Peter et al., 2002)
Other Comments
	Rho1 is an upstream regulator of DAAM, while Src42A and Btk29A act downstream or in parallel of DAAM. (Matusek et al., 2006) Appears to be function downstream of Rho1 and upstream of Src42A and Btk29A. (Matusek et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_130544 NM_166875 NM_166876 NM_001201593 NM_001272197 RefSeq (Proteins) • NP_569900 NP_726723 NP_726724 NP_001188522 NP_001259126 DDBJ / EMBL / GenBank • AA942048 AAF45600 AAF45601 AAM48468 AAN09040 AAX33390 ADV37606 AF171816 AGB94972 AL031640 AY118439 BI484790 BI631718 BT021242 CAA21052 CZ479464 CZ482270 CZ482271 CZ488700 CZ489112 CZ489113 Entrez Gene - A searchable database of RefSeq genes. • 31075 UniProtKB/TrEMBL • Q5BII2 Q7KW17 Q7YZA4 Q8IRY0 Q8MT16 Q9W5A4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Actin-binding FH2/DRF autoregulatory (IPR003104) Diaphanous FH3 (IPR010472) GTPase-binding/formin homology 3 (IPR014768) Actin-binding FH2 (IPR015425) Diaphanous autoregulatory (IPR014767) Diaphanous GTPase-binding (IPR010473) Armadillo-type fold (IPR016024) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH61354
Linkouts
	BioGRID - A database of protein and genetic interactions • 57637 DroID - A comprehensive database of gene and protein interactions. • FBgn0025641 DRSC - Results from RNAi screens. • FBgn0025641 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025641 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14622-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025641 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 351102 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31075 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/damm1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31075 modMine - Data generated by the modENCODE project. • FBgn0025641
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	anon-EST:Posey148   CG14622 (Goldstein and Gunawardena, 2000, Tanaka et al., 2004, Benos, 2000.12.13, Matusek et al., 2006, Rogers et al., 2003, Negre et al., 2006, Georlette et al., 2007, Keleman et al., 2009.8.5, Zeitlinger et al., 2007, Aerts et al., 2010, Ni et al., 2010.12.1) DAAM (Matusek et al., 2006, Matusek et al., 2008, Barkó et al., 2010, Aerts et al., 2010, Wasbrough et al., 2010, Gonçalves-Pimentel et al., 2011, Japanese National Institute of Genetics, 2012.5.21) daam (Leptin, 2005, Sánchez-Soriano et al., 2010) Daam (Warner and Longmore, 2009) dDAAM (Matusek et al., 2005, Matusek et al., 2008) dDaam (Nelson et al., 2012) EG:114D9.2 (Peter et al., 2002, Benos et al., 2001, Giot et al., 2003, Stuart et al., 2007) unnamed (Goldstein and Gunawardena, 2000)
Name Synonym	DIA-like (Rogers et al., 2003) Dishevelled Associated Activator of Morphogenesis (Matusek, 2005.9.6, Matusek et al., 2005) Dishevelled associated activator of morphogenesis (Matusek et al., 2006) Formin (Rogers et al., 2003, Pimentel et al., 2007, Cao et al., 2010)
Secondary FlyBase IDs
	FBgn0027752
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 12 ) Review  ( 2 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Nelson et al., 2012, Nat. Cell Biol. 14(5): 518--525 Drosophila Src regulates anisotropic apical surface growth to control epithelial tube size. [FBrf0218197] Gonçalves-Pimentel et al., 2011, PLoS ONE 6(3): e18340 Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model. [FBrf0213367] Show all research papers ...
Recent reviews ( 1 )
	Prokop et al., 2011, Commun. Integr. Biol. 4(5): 538--542 DAAM family members leading a novel path into formin research. [FBrf0216640] Show all reviews ...