FB2025_01 , released February 20, 2025
Gene: Dmel\CycK
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General Information
Symbol
Dmel\CycK
Species
D. melanogaster
Name
Cyclin K
Annotation Symbol
CG15218
Feature Type
protein_coding_gene
FlyBase ID
FBgn0025674
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Cyclin K (CycK) encodes a Cyclin-homologous subunit that forms a complex with the transcriptional kinase encoded by Cdk12. This complex phosphorylates the carboxy terminal domain of the large subunit of RNA polymerase II (encoded by Polr2A) and contributes to pre-mRNA processing, transcription and chromatin structure. [Date last reviewed: 2018-10-18] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
40E4-40E4
Sequence location
Recombination map
2-54
RefSeq locus
NT_033779 REGION:22124285..22130142
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:Q9VP22
(Bartkowiak et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables cyclin-dependent protein serine/threonine kinase activator activity
inferred from biological aspect of ancestor with PANTHER:PTN000002653
(GO Reference Genome Project, 2011-)
enables cyclin-dependent protein serine/threonine kinase regulator activity
inferred from electronic annotation with InterPro:IPR043198
(InterPro Project Members, 2004-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in positive regulation of DNA-templated transcription, elongation
inferred from biological aspect of ancestor with PANTHER:PTN000002653
(GO Reference Genome Project, 2011-)
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000002653
(GO Reference Genome Project, 2011-)
involved_in regulation of transcription by RNA polymerase II
inferred from electronic annotation with InterPro:IPR043198
(InterPro Project Members, 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of cyclin/CDK positive transcription elongation factor complex
inferred from biological aspect of ancestor with PANTHER:PTN000002653
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000002458
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Cyclin K (CycK) encodes a Cyclin-homologous subunit that forms a complex with the transcriptional kinase encoded by Cdk12. This complex phosphorylates the carboxy terminal domain of the large subunit of RNA polymerase II (encoded by Polr2A) and contributes to pre-mRNA processing, transcription and chromatin structure. [Date last reviewed: 2018-10-18]
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CycK for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q961D1)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 5.53

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CycK-RA
FBtr0085941
NM_176068
1879
400
CycK-RB
FBtr0085942
NM_176069
1679
400
CycK-RC
FBtr0344022
NM_001299202
5858
400
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
CycK-PA
FBpp0085295
44.8
400
8.09
Q961D1
NP_788082
AAN11146
CycK-PB
FBpp0085296
44.8
400
8.09
Q961D1
NP_788083
AAN11147
CycK-PC
FBpp0310472
44.8
400
8.09
Q961D1
NP_001286131
AHN54645
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

400 aa isoforms: CycK-PA, CycK-PB, CycK-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CycK using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.69

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | faint | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CycK in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CycK
Transgenic constructs containing regulatory region of CycK
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene partially disrupted in
Df(2L)CRIMIC-CR71196
(Gene Disruption Project members, 2018-)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (12)
Hsap\CCNK
12 of 14
Yes
Yes
Hsap\CCNL1
3 of 14
No
No
1  
Hsap\CCNL2
3 of 14
No
No
Hsap\CCNT1
3 of 14
No
No
Hsap\CCNT2
3 of 14
No
No
Hsap\CCNC
2 of 14
No
No
1  
Hsap\CCNH
2 of 14
No
No
1  
Hsap\CCNQ
2 of 14
No
No
Hsap\CCNA1
1 of 14
No
No
Hsap\CCNA2
1 of 14
No
No
Hsap\CCND2
1 of 14
No
No
1  
Hsap\GTF2B
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (8)
Rnor\Ccnk
10 of 14
Yes
Yes
Rnor\Ccnl1
3 of 14
No
No
Rnor\Ccnl2
3 of 14
No
No
Rnor\Ccnt2
3 of 14
No
No
Rnor\Ccnc
2 of 14
No
No
Rnor\Ccnh
2 of 14
No
No
Rnor\Ccnq
2 of 14
No
No
Rnor\Ccnt1
2 of 14
No
No
Mus musculus (laboratory mouse) (8)
Mmus\Ccnk
11 of 14
Yes
Yes
Mmus\Ccnl1
3 of 14
No
No
Mmus\Ccnl2
3 of 14
No
No
Mmus\Ccnc
2 of 14
No
No
Mmus\Ccnh
2 of 14
No
No
Mmus\Ccnq
2 of 14
No
No
Mmus\Ccnt1
2 of 14
No
No
Mmus\Ccnt2
2 of 14
No
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\ccnk
7 of 13
Yes
Yes
Xtro\ccnl2
2 of 13
No
No
Xtro\ccnb2
1 of 13
No
No
Xtro\ccnb3
1 of 13
No
No
Xtro\ccnc
1 of 13
No
No
Xtro\ccnh
1 of 13
No
No
Xtro\ccnt1
1 of 13
No
No
Xtro\ccnt2
1 of 13
No
No
Xtro\LOC394448
1 of 13
No
No
Xtro\otogl2
1 of 13
No
No
Xtro\XB5961763
1 of 13
No
No
Danio rerio (Zebrafish) (10)
Drer\ccnk
11 of 14
Yes
Yes
Drer\ccnl1a
3 of 14
No
No
Drer\ccnl1b
3 of 14
No
No
Drer\ccnt1
3 of 14
No
No
Drer\ccnt2a
3 of 14
No
No
Drer\ccnt2b
3 of 14
No
No
Drer\ccnc
2 of 14
No
No
Drer\ccnh
2 of 14
No
No
Drer\ccnq
2 of 14
No
No
Drer\myo18ab
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\ccnk-1
13 of 14
Yes
Yes
Cele\cic-1
2 of 14
No
No
Cele\cit-1.1
2 of 14
No
No
Cele\cit-1.2
2 of 14
No
No
Cele\cyh-1
2 of 14
No
No
Cele\cyl-1
2 of 14
No
No
Cele\ttn-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (8)
Agam\AgaP_AGAP008002
12 of 12
Yes
Yes
Agam\AgaP_AGAP006678
3 of 12
No
No
Agam\AgaP_AGAP005056
2 of 12
No
No
Agam\AgaP_AGAP008417
2 of 12
No
No
Agam\AgaP_AGAP012763
2 of 12
No
No
Agam\CCNC_ANOGA
2 of 12
No
No
Agam\AgaP_AGAP001677
1 of 12
No
No
Agam\AgaP_AGAP004962
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (15)
Atha\AT5G45190
12 of 13
Yes
Yes
Atha\CYCT1;4
12 of 13
Yes
Yes
Atha\CYCT1;1
10 of 13
No
Yes
Atha\CYCT1;2
10 of 13
No
Yes
Atha\CYCT1;3
8 of 13
No
Yes
Atha\RCY1
4 of 13
No
No
Atha\AT5G48630
2 of 13
No
No
Atha\AT5G48640
2 of 13
No
No
Atha\CYCH;1
2 of 13
No
No
Atha\AT3G10330
1 of 13
No
No
Atha\CYCB1;3
1 of 13
No
No
Atha\CYCB2;3
1 of 13
No
No
Atha\CYCB2;4
1 of 13
No
No
Atha\CYCB3;1
1 of 13
No
No
Atha\CYCD3;1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\CTK2
5 of 13
Yes
Yes
Scer\BUR2
2 of 13
No
Yes
Scer\CCL1
2 of 13
No
No
Scer\SSN8
2 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\pch1
9 of 12
Yes
Yes
Spom\lsc1
4 of 12
No
Yes
Spom\mcs2
2 of 12
No
No
Spom\SPAC1296.05c
2 of 12
No
No
Spom\srb11
2 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:CycK. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (7)
CycT
6 of 13
CG16903
5 of 13
CycC
4 of 13
CycH
4 of 13
koko
3 of 13
CycA
1 of 13
TfIIB
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CCNK; cyclin K
    12 of 14
    603544
      CCNL1; cyclin L1
      3 of 14
      613384
           
          CCNL2; cyclin L2
          3 of 14
          613482
              CCNT1; cyclin T1
              3 of 14
              143055
                  CCNT2; cyclin T2
                  3 of 14
                  603862
                      Functional Complementation Data
                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                      Interactions
                      Summary of Physical Interactions
                      Summary of Genetic Interactions
                      esyN Network Diagram
                      Other Interaction Browsers
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      External Data
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      DroID - A comprehensive database of gene and protein interactions.
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Pathways
                      Signaling Pathways (FlyBase)
                      Metabolic Pathways
                      FlyBase
                      External Links
                      External Data
                      Class of Gene
                      Genomic Location and Detailed Mapping Data
                      Chromosome (arm)
                      2L
                      Recombination map
                      2-54
                      Cytogenetic map
                      40E4-40E4
                      Sequence location
                      FlyBase Computed Cytological Location
                      Cytogenetic map
                      Evidence for location
                      40E4-40E4
                      Limits computationally determined from genome sequence between P{lacW}Df31k05815 and P{PZ}cul-202074&P{lacW}l(2)k08110k08110
                      Experimentally Determined Cytological Location
                      Cytogenetic map
                      Notes
                      References
                      Experimentally Determined Recombination Data
                      Location

                      2-54

                      (FlyBase, 2016)

                      2-54.6

                      (Comeron et al., 2012)
                      Left of (cM)
                      Right of (cM)
                      Notes
                      Stocks and Reagents
                      Stocks (8)
                      Genomic Clones (21)
                      cDNA Clones (61)
                       

                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                      cDNA clones, fully sequenced
                      BDGP DGC clones
                      Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      Antibody Information
                      Laboratory Generated Antibodies
                       
                      Commercially Available Antibodies
                       
                      Cell Line Information
                      Publicly Available Cell Lines
                       
                        Other Stable Cell Lines
                         
                          Other Comments

                          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                          (Kiger et al., 2003)
                          Relationship to Other Genes
                          Source for database merge of

                          Source for merge of: CycK CG15218

                          (Bayraktaroglu, 2000.11.2)
                          Additional comments
                          Nomenclature History
                          Source for database identify of
                          Nomenclature comments
                          Etymology
                          Synonyms and Secondary IDs (7)
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          Study result (0)
                          Result
                          Result Type
                          Title
                          External Crossreferences and Linkouts ( 51 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                          FlyMine - An integrated database for Drosophila genomics
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          Linkouts
                          BioGRID - A database of protein and genetic interactions.
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          Flygut - An atlas of the Drosophila adult midgut
                          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                          References (56)