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Gene Dmel\CG11592

General Information
Symbol	Dmel\CG11592	Species	D. melanogaster
Name		Annotation symbol	CG11592
Feature type	protein_coding_gene	FlyBase ID	FBgn0025686
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	21B7-21B7	Sequence location	2L:287,252..288,919 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11592 (FBgn0025686). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: lateral inhibition. 3 alleles are reported. The phenotype of these alleles is annotated with: chaeta. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult heart. Comments on Affy2 ProbeSet: ProbeSet 1623953_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11592. Gene sequence location is 2L:287252..288919.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA00317 BKN24958
FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 22 of adulthood day 20 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21B7-21B7   Limits computationally determined from genome sequence between P{lacW}spenk06805&P{lacW}l(2)k13604k13604 and P{lacW}U2af38k14504
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11592 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11592-RA FBtr0078134  NM_134671   1668   505
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11592-PA   FBpp0077793   56.9   505   4.48     NP_608515   AAF51514
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141784   AE014134 AAF51514   BT023193   CO307682   CO325480   CZ468687   EC203601   EL871301   EL871420
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VPN2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0025686    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0025686 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0025686 expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    34 embryo 04-06hr    20 embryo 06-08hr    126 embryo 08-10hr    355 embryo 10-12hr    497 embryo 12-14hr    633 embryo 14-16hr    693 embryo 16-18hr    975 embryo 18-20hr    977 embryo 20-22hr    661 embryo 22-24hr    744 larva L1    429 larva L2    375 larva L3 12hr old    600 larva L3 puffstage 1-2    216 larva L3 puffstage 3-6    279 larva L3 puffstage 7-9    639 white prepupae new    874 white prepupae 12hr    627 white prepupae 24hr    423 pupae 2d postWPP    144 pupae 3d postWPP    168 pupae 4d postWPP    172 adult male 01day    366 adult male 05day    227 adult male 30day    45 adult female 01day    167 adult female 05day    146 adult female 30day    65 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    34 embryo 04-06hr    20 embryo 06-08hr  (126) embryo 08-10hr  (355) embryo 10-12hr  (497) embryo 12-14hr  (633) embryo 14-16hr  (693) embryo 16-18hr  (975) embryo 18-20hr  (977) embryo 20-22hr  (661) embryo 22-24hr  (744) larva L1  (429) larva L2  (375) larva L3 12hr old  (600) larva L3 puffstage 1-2  (216) larva L3 puffstage 3-6  (279) larva L3 puffstage 7-9  (639) white prepupae new  (874) white prepupae 12hr  (627) white prepupae 24hr  (423) pupae 2d postWPP  (144) pupae 3d postWPP  (168) pupae 4d postWPP  (172) adult male 01day  (366) adult male 05day  (227) adult male 30day    45 adult female 01day  (167) adult female 05day  (146) adult female 30day    65 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    34 embryo 04-06hr    20 embryo 06-08hr    126 embryo 08-10hr    355 embryo 10-12hr    497 embryo 12-14hr    633 embryo 14-16hr    693 embryo 16-18hr    975 embryo 18-20hr    977 embryo 20-22hr    661 embryo 22-24hr    744 larva L1    429 larva L2    375 larva L3 12hr old    600 larva L3 puffstage 1-2    216 larva L3 puffstage 3-6    279 larva L3 puffstage 7-9    639 white prepupae new    874 white prepupae 12hr    627 white prepupae 24hr    423 pupae 2d postWPP    144 pupae 3d postWPP    168 pupae 4d postWPP    172 adult male 01day    366 adult male 05day    227 adult male 30day    45 adult female 01day    167 adult female 05day    146 adult female 30day    65 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    34 embryo 04-06hr    20 embryo 06-08hr    126 embryo 08-10hr    355 embryo 10-12hr    497 embryo 12-14hr    633 embryo 14-16hr    693 embryo 16-18hr    975 embryo 18-20hr    977 embryo 20-22hr    661 embryo 22-24hr    744 larva L1    429 larva L2    375 larva L3 12hr old    600 larva L3 puffstage 1-2    216 larva L3 puffstage 3-6    279 larva L3 puffstage 7-9    639 white prepupae new    874 white prepupae 12hr    627 white prepupae 24hr    423 pupae 2d postWPP    144 pupae 3d postWPP    168 pupae 4d postWPP    172 adult male 01day    366 adult male 05day    227 adult male 30day    45 adult female 01day    167 adult female 05day    146 adult female 30day    65 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    34 embryo 04-06hr    20 embryo 06-08hr    126 embryo 08-10hr    355 embryo 10-12hr    497 embryo 12-14hr    633 embryo 14-16hr    693 embryo 16-18hr    975 embryo 18-20hr    977 embryo 20-22hr    661 embryo 22-24hr    744 larva L1    429 larva L2    375 larva L3 12hr old    600 larva L3 puffstage 1-2    216 larva L3 puffstage 3-6    279 larva L3 puffstage 7-9    639 white prepupae new    874 white prepupae 12hr    627 white prepupae 24hr    423 pupae 2d postWPP    144 pupae 3d postWPP    168 pupae 4d postWPP    172 adult male 01day    366 adult male 05day    227 adult male 30day    45 adult female 01day    167 adult female 05day    146 adult female 30day    65 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0025686 expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    34 embryo 04-06hr    20 embryo 06-08hr    126 embryo 08-10hr    355 embryo 10-12hr    497 embryo 12-14hr    633 embryo 14-16hr    693 embryo 16-18hr    975 embryo 18-20hr    977 embryo 20-22hr    661 embryo 22-24hr    744 larva L1    429 larva L2    375 larva L3 12hr old    600 larva L3 puffstage 1-2    216 larva L3 puffstage 3-6    279 larva L3 puffstage 7-9    639 white prepupae new    874 white prepupae 12hr    627 white prepupae 24hr    423 pupae 2d postWPP    144 pupae 3d postWPP    168 pupae 4d postWPP    172 adult male 01day    366 adult male 05day    227 adult male 30day    45 adult female 01day    167 adult female 05day    146 adult female 30day    65 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    34 embryo 04-06hr    20 embryo 06-08hr  126 embryo 08-10hr  (355) embryo 10-12hr  (497) embryo 12-14hr  (633) embryo 14-16hr  (693) embryo 16-18hr  (975) embryo 18-20hr  (977) embryo 20-22hr  (661) embryo 22-24hr  (744) larva L1  (429) larva L2  (375) larva L3 12hr old  (600) larva L3 puffstage 1-2  (216) larva L3 puffstage 3-6  (279) larva L3 puffstage 7-9  (639) white prepupae new  (874) white prepupae 12hr  (627) white prepupae 24hr  (423) pupae 2d postWPP  (144) pupae 3d postWPP  (168) pupae 4d postWPP  (172) adult male 01day  (366) adult male 05day  (227) adult male 30day    45 adult female 01day  (167) adult female 05day  (146) adult female 30day    65 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    34 embryo 04-06hr    20 embryo 06-08hr    126 embryo 08-10hr    355 embryo 10-12hr    497 embryo 12-14hr    633 embryo 14-16hr    693 embryo 16-18hr    975 embryo 18-20hr    977 embryo 20-22hr    661 embryo 22-24hr    744 larva L1    429 larva L2    375 larva L3 12hr old    600 larva L3 puffstage 1-2    216 larva L3 puffstage 3-6    279 larva L3 puffstage 7-9    639 white prepupae new    874 white prepupae 12hr    627 white prepupae 24hr    423 pupae 2d postWPP    144 pupae 3d postWPP    168 pupae 4d postWPP    172 adult male 01day    366 adult male 05day    227 adult male 30day    45 adult female 01day    167 adult female 05day    146 adult female 30day    65 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    34 embryo 04-06hr    20 embryo 06-08hr    126 embryo 08-10hr    355 embryo 10-12hr    497 embryo 12-14hr    633 embryo 14-16hr    693 embryo 16-18hr    975 embryo 18-20hr    977 embryo 20-22hr    661 embryo 22-24hr    744 larva L1    429 larva L2    375 larva L3 12hr old    600 larva L3 puffstage 1-2    216 larva L3 puffstage 3-6    279 larva L3 puffstage 7-9    639 white prepupae new    874 white prepupae 12hr    627 white prepupae 24hr    423 pupae 2d postWPP    144 pupae 3d postWPP    168 pupae 4d postWPP    172 adult male 01day    366 adult male 05day    227 adult male 30day    45 adult female 01day    167 adult female 05day    146 adult female 30day    65 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    34 embryo 04-06hr    20 embryo 06-08hr    126 embryo 08-10hr    355 embryo 10-12hr    497 embryo 12-14hr    633 embryo 14-16hr    693 embryo 16-18hr    975 embryo 18-20hr    977 embryo 20-22hr    661 embryo 22-24hr    744 larva L1    429 larva L2    375 larva L3 12hr old    600 larva L3 puffstage 1-2    216 larva L3 puffstage 3-6    279 larva L3 puffstage 7-9    639 white prepupae new    874 white prepupae 12hr    627 white prepupae 24hr    423 pupae 2d postWPP    144 pupae 3d postWPP    168 pupae 4d postWPP    172 adult male 01day    366 adult male 05day    227 adult male 30day    45 adult female 01day    167 adult female 05day    146 adult female 30day    65 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0025686    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0025686 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult heart. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0025686 expression level Tissue   Expression Level Larval Central Nervous System    0.775 Larval Midgut no informative data Larval Hindgut    0.6 Larval Malpighian Tubules    92.3 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    71 Adult Head    0.8 Adult Eye    1.225 Adult Brain    3.4 Adult Thoracic-Abdominal Ganglion    4.6 Adult Crop    0.6 Adult Midgut    1.5 Adult Hindgut    9.6 Adult Malpighian Tubules    5.4 Adult Fat Body no informative data Adult Salivary Gland    7.5 Adult Heart    2965.925 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    0.4 Adult Testis    2.4 Adult Male Accessory Gland    1.4 Adult Carcass    85.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.775 Larval Midgut no informative data Larval Hindgut    0.6 Larval Malpighian Tubules    92.3 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    71 Adult Head    0.8 Adult Eye    1.225 Adult Brain    3.4 Adult Thoracic-Abdominal Ganglion    4.6 Adult Crop    0.6 Adult Midgut    1.5 Adult Hindgut    9.6 Adult Malpighian Tubules    5.4 Adult Fat Body no informative data Adult Salivary Gland    7.5 Adult Heart  (2965.925) Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    0.4 Adult Testis    2.4 Adult Male Accessory Gland    1.4 Adult Carcass    85.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.775 Larval Midgut no informative data Larval Hindgut    0.6 Larval Malpighian Tubules    92.3 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    71 Adult Head    0.8 Adult Eye    1.225 Adult Brain    3.4 Adult Thoracic-Abdominal Ganglion    4.6 Adult Crop    0.6 Adult Midgut    1.5 Adult Hindgut    9.6 Adult Malpighian Tubules    5.4 Adult Fat Body no informative data Adult Salivary Gland    7.5 Adult Heart  (2965.925) Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    0.4 Adult Testis    2.4 Adult Male Accessory Gland    1.4 Adult Carcass    85.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.775 Larval Midgut no informative data Larval Hindgut    0.6 Larval Malpighian Tubules    92.3 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    71 Adult Head    0.8 Adult Eye    1.225 Adult Brain    3.4 Adult Thoracic-Abdominal Ganglion    4.6 Adult Crop    0.6 Adult Midgut    1.5 Adult Hindgut    9.6 Adult Malpighian Tubules    5.4 Adult Fat Body no informative data Adult Salivary Gland    7.5 Adult Heart    2965.925 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    0.4 Adult Testis    2.4 Adult Male Accessory Gland    1.4 Adult Carcass    85.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0025686 expression level Tissue   Expression Level Larval Central Nervous System    0.775 Larval Midgut no informative data Larval Hindgut    0.6 Larval Malpighian Tubules    92.3 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    71 Adult Head    0.8 Adult Eye    1.225 Adult Brain    3.4 Adult Thoracic-Abdominal Ganglion    4.6 Adult Crop    0.6 Adult Midgut    1.5 Adult Hindgut    9.6 Adult Malpighian Tubules    5.4 Adult Fat Body no informative data Adult Salivary Gland    7.5 Adult Heart    2965.925 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    0.4 Adult Testis    2.4 Adult Male Accessory Gland    1.4 Adult Carcass    85.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.775 Larval Midgut no informative data Larval Hindgut    0.6 Larval Malpighian Tubules    92.3 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    71 Adult Head    0.8 Adult Eye    1.225 Adult Brain    3.4 Adult Thoracic-Abdominal Ganglion    4.6 Adult Crop    0.6 Adult Midgut    1.5 Adult Hindgut    9.6 Adult Malpighian Tubules    5.4 Adult Fat Body no informative data Adult Salivary Gland    7.5 Adult Heart  (2965.925) Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    0.4 Adult Testis    2.4 Adult Male Accessory Gland    1.4 Adult Carcass    85.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.775 Larval Midgut no informative data Larval Hindgut    0.6 Larval Malpighian Tubules    92.3 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    71 Adult Head    0.8 Adult Eye    1.225 Adult Brain    3.4 Adult Thoracic-Abdominal Ganglion    4.6 Adult Crop    0.6 Adult Midgut    1.5 Adult Hindgut    9.6 Adult Malpighian Tubules    5.4 Adult Fat Body no informative data Adult Salivary Gland    7.5 Adult Heart  (2965.925) Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    0.4 Adult Testis    2.4 Adult Male Accessory Gland    1.4 Adult Carcass    85.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.775 Larval Midgut no informative data Larval Hindgut    0.6 Larval Malpighian Tubules    92.3 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    71 Adult Head    0.8 Adult Eye    1.225 Adult Brain    3.4 Adult Thoracic-Abdominal Ganglion    4.6 Adult Crop    0.6 Adult Midgut    1.5 Adult Hindgut    9.6 Adult Malpighian Tubules    5.4 Adult Fat Body no informative data Adult Salivary Gland    7.5 Adult Heart    2965.925 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    0.4 Adult Testis    2.4 Adult Male Accessory Gland    1.4 Adult Carcass    85.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    0.8   NA  Eye    1.225   NA  Brain    3.4   0.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4.6   NA  Crop    0.6   no informative data  Midgut    1.5   0.6  Hindgut    9.6   92.3  Malpighian Tubules    5.4   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    7.5   NA  Heart    2965.925   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    1.7   NA  InseminatedFemale Spermatheca    2.8   NA  Ovary    0.4   NA  Testis    2.4   NA  Male Accessory Gland    1.4   71  Carcass    85.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025686 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11592-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 CG11592GD781 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 CG11592GD781 Phenotype manifest in Allele chaeta, with Scer\GAL4pnr-MD237 CG11592GD781
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG11592 Class Mutagen Stocks Known lesion CG11592c03503 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11592 Class Mutagen Stocks Known lesion CG11592GD781 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11592KK103998 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel8001 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD781} NA P{KK103998} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}CG11592c03503 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11592 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025686 DroID - A comprehensive database of gene and protein interactions. • FBgn0025686 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33199
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24904 Dere\GG24661 Dgri\GH10219 Dmoj\GI15029 Dper\GL25825 Dpse\GA11086 Dsec\GM16681 Dsim\GD22969 Dvir\GJ17241 Dwil\GK14824 Dyak\GE16249
Curated drosophilid orthologs	Dpse\GA11086
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000662-PA Aedes aegypti (mosquito) AGAP012405-PA Anopheles gambiae (mosquito) 78846 Branchiostoma floridae (lancelet) 82292 Branchiostoma floridae (lancelet) BGIBMGA012714-PA Bombyx mori (silk worm) ENSBTAP00000020912 Bos taurus (bovine) CPIJ013563 Culex pipens (mosquito) 221105 Capitella spl (polychaete worm) 254308 Daphnia pulex (daphnia) ENSDARP00000085989 Danio rerio (zebra fish) ENSGALP00000018558 Gallus gallus (chicken) ENSP00000299155 Homo sapiens (human) ENSMODP00000031834 Monodelphis domestica (gray opossum) ENSOANP00000023056 Ornithorynchus anatinus (platypus) PHUM009494-PA Pediculus humanus (human body louse) ENSPPYP00000007004 Pongo pygmaeus (orangutan) ENSPTRP00000011506 Pan troglodytes (chimpanzee) ENSTRUP00000030672 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000027872 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14341 LH20781 ISCW007271 FBgn0233787 FBgn0216829 FBgn0204417 FBgn0194362 FBgn0171594 FBgn0168201 JGI_V11_254308 FBgn0071141 FBgn0163409 FBgn0137779 FBgn0117700 FBgn0116793 FBgn0101896 CPIJ013563 CPIJ005223 BGIBMGA012714 ACYPI003658 GB16653 AGAP012405 AAEL000662 PB20396 PHUM422850 GLEAN_15155
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Harvard	- PBac{PB}CG11592c03503
VDRC	v104099 P{KK103998}VIE-260B v2495 w1118; P{GD781}v2495/TM3
Genomic Clones ( 1 )
	BACR22C14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 7 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP03221
Other clones	DPiM_IP03221
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	CK02467 EK196625 EK255235 IP03421 IP03521
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025686 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33199
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: BEST:CK02467 CG11592 (Bayraktaroglu, 2000.11.2)
Additional comments
Other Comments
	Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis. (Kopczynski et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134671 RefSeq (Proteins) • NP_608515 DDBJ / EMBL / GenBank • AA141784 AAF51514 CZ468687 Entrez Gene - A searchable database of RefSeq genes. • 33199 UniProtKB/TrEMBL • Q9VPN2
Other Crossreferences
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025686 DroID - A comprehensive database of gene and protein interactions. • FBgn0025686 DRSC - Results from RNAi screens. • FBgn0025686 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025686 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11592-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025686 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33199 InParanoid A subset of ortholog calls from InParanoid. • AAEL000662-PA Aedes aegypti (mosquito) AGAP012405-PA Anopheles gambiae (mosquito) 78846 Branchiostoma floridae (lancelet) 82292 Branchiostoma floridae (lancelet) BGIBMGA012714-PA Bombyx mori (silk worm) ENSBTAP00000020912 Bos taurus (bovine) CPIJ013563 Culex pipens (mosquito) 221105 Capitella spl (polychaete worm) 254308 Daphnia pulex (daphnia) ENSDARP00000085989 Danio rerio (zebra fish) ENSGALP00000018558 Gallus gallus (chicken) ENSP00000299155 Homo sapiens (human) ENSMODP00000031834 Monodelphis domestica (gray opossum) ENSOANP00000023056 Ornithorynchus anatinus (platypus) PHUM009494-PA Pediculus humanus (human body louse) ENSPPYP00000007004 Pongo pygmaeus (orangutan) ENSPTRP00000011506 Pan troglodytes (chimpanzee) ENSTRUP00000030672 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000027872 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33199 modMine - Data generated by the modENCODE project. • FBgn0025686 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14341 LH20781 ISCW007271 FBgn0233787 FBgn0216829 FBgn0204417 FBgn0194362 FBgn0171594 FBgn0168201 JGI_V11_254308 FBgn0071141 FBgn0163409 FBgn0137779 FBgn0117700 FBgn0116793 FBgn0101896 CPIJ013563 CPIJ005223 BGIBMGA012714 ACYPI003658 GB16653 AGAP012405 AAEL000662 PB20396 PHUM422850 GLEAN_15155
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BEST:CK02467   CG11592 (Keleman et al., 2009.8.5, Cammarato et al., 2011) CK02467 (Kopczynski et al., 1998)
Name Synonym
Secondary FlyBase IDs
	FBgn0031246
References ( 12 )
Research paper	Kopczynski et al., 1998, Proc. Natl. Acad. Sci. USA 95(17): 9973--9978 A high throughput screen to identify secreted and transmembrane proteins involved in Drosophila embryogenesis. [FBrf0104467]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Bayraktaroglu, 2000.11.2, Current list of possibly CG-able known genes. Current list of possibly CG-able known genes. [FBrf0131225]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]