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Gene Dmel\CG11163

General Information
Symbol	Dmel\CG11163	Species	D. melanogaster
Name		Annotation symbol	CG11163
Feature type	protein_coding_gene	FlyBase ID	FBgn0025693
Gene Model Status	Current	Stock availability	11 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	41F10-41F11	Sequence location	2R:1,662,279..1,670,360 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11163 (FBgn0025693). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: zinc ion transmembrane transporter activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: transmembrane transport; cation transport. 13 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Cation efflux protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult fat body, adult spermathecae. Comments on Affy2 ProbeSet: ProbeSet 1641164_s_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of CG11163. Gene sequence location is 2R:1662279..1670360.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA04850 BKN31282
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 41F10-41F11   Limits computationally determined from genome sequence between P{PZ}l(2)0985109851&P{lacW}Src42Ak10108 and P{lacW}l(2)k09848k09848&P{EP}EP407
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11163 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11163-RA FBtr0086053  NM_136341   1958   498 CG11163-RB FBtr0086054  NM_165446   2460   498 CG11163-RC FBtr0086055  NM_165447   2060   498 CG11163-RD FBtr0086056  NM_165448   1982   498
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11163-PA   FBpp0085389   55.0   498   5.93     NP_610185   AAF57308 CG11163-PB   FBpp0085390   55.0   498   5.93     NP_724429   AAM68358 CG11163-PC   FBpp0085391   55.0   498   5.93     NP_724430   AAM68359 CG11163-PD   FBpp0085392   55.0   498   5.93     NP_724431   AAM68360
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cation efflux protein (IPR002524)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141405   AA141494   AA246577   AE013599 AAF57308   AE013599 AAM68358   AE013599 AAM68359   AE013599 AAM68360   AW941584   AY069340 AAL39485   AZ300926   BH610063   BI212303   BI212884   BI239473   BI240319   BI361308   BI361330   BI372663   BP548225   CK661799   CL632187   CO176935   CO188070   CO190961   CO270748   CO275286   CO281448   CO288250   CO298877   CO313039   CO314605   CO321119   CO342575   CZ471414   CZ474861   CZ477998   CZ481525   CZ481526   CZ485255   CZ485256   EC058131   EC069234   EC070130   EC080964   EC082772   EC087954   EC198175   EC198232   EC202923   EC217072   EC257258   GH958455   GH964021   GH977041   GH980137   GH980888
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8T0G1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0025693    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0025693 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0025693 expression level Developmental Stage   Expression Level embryo 00-02hr    567 embryo 02-04hr    382 embryo 04-06hr    254 embryo 06-08hr    528 embryo 08-10hr    867 embryo 10-12hr    1047 embryo 12-14hr    1295 embryo 14-16hr    629 embryo 16-18hr    928 embryo 18-20hr    796 embryo 20-22hr    1111 embryo 22-24hr    1526 larva L1    948 larva L2    1112 larva L3 12hr old    793 larva L3 puffstage 1-2    898 larva L3 puffstage 3-6    1227 larva L3 puffstage 7-9    2326 white prepupae new    1917 white prepupae 12hr    984 white prepupae 24hr    1057 pupae 2d postWPP    567 pupae 3d postWPP    303 pupae 4d postWPP    372 adult male 01day    755 adult male 05day    687 adult male 30day    661 adult female 01day    556 adult female 05day    617 adult female 30day    647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (567) embryo 02-04hr  (382) embryo 04-06hr  (254) embryo 06-08hr  (528) embryo 08-10hr  (867) embryo 10-12hr  (1047) embryo 12-14hr  (1295) embryo 14-16hr  (629) embryo 16-18hr  (928) embryo 18-20hr  (796) embryo 20-22hr  (1111) embryo 22-24hr  (1526) larva L1  (948) larva L2  (1112) larva L3 12hr old  (793) larva L3 puffstage 1-2  (898) larva L3 puffstage 3-6  (1227) larva L3 puffstage 7-9  (2326) white prepupae new  (1917) white prepupae 12hr  (984) white prepupae 24hr  (1057) pupae 2d postWPP  (567) pupae 3d postWPP  (303) pupae 4d postWPP  (372) adult male 01day  (755) adult male 05day  (687) adult male 30day  (661) adult female 01day  (556) adult female 05day  (617) adult female 30day  (647) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    567 embryo 02-04hr    382 embryo 04-06hr    254 embryo 06-08hr    528 embryo 08-10hr    867 embryo 10-12hr    1047 embryo 12-14hr    1295 embryo 14-16hr    629 embryo 16-18hr    928 embryo 18-20hr    796 embryo 20-22hr    1111 embryo 22-24hr  (1526) larva L1    948 larva L2    1112 larva L3 12hr old    793 larva L3 puffstage 1-2    898 larva L3 puffstage 3-6    1227 larva L3 puffstage 7-9  (2326) white prepupae new  (1917) white prepupae 12hr    984 white prepupae 24hr    1057 pupae 2d postWPP    567 pupae 3d postWPP    303 pupae 4d postWPP    372 adult male 01day    755 adult male 05day    687 adult male 30day    661 adult female 01day    556 adult female 05day    617 adult female 30day    647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    567 embryo 02-04hr    382 embryo 04-06hr    254 embryo 06-08hr    528 embryo 08-10hr    867 embryo 10-12hr    1047 embryo 12-14hr    1295 embryo 14-16hr    629 embryo 16-18hr    928 embryo 18-20hr    796 embryo 20-22hr    1111 embryo 22-24hr    1526 larva L1    948 larva L2    1112 larva L3 12hr old    793 larva L3 puffstage 1-2    898 larva L3 puffstage 3-6    1227 larva L3 puffstage 7-9    2326 white prepupae new    1917 white prepupae 12hr    984 white prepupae 24hr    1057 pupae 2d postWPP    567 pupae 3d postWPP    303 pupae 4d postWPP    372 adult male 01day    755 adult male 05day    687 adult male 30day    661 adult female 01day    556 adult female 05day    617 adult female 30day    647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    567 embryo 02-04hr    382 embryo 04-06hr    254 embryo 06-08hr    528 embryo 08-10hr    867 embryo 10-12hr    1047 embryo 12-14hr    1295 embryo 14-16hr    629 embryo 16-18hr    928 embryo 18-20hr    796 embryo 20-22hr    1111 embryo 22-24hr    1526 larva L1    948 larva L2    1112 larva L3 12hr old    793 larva L3 puffstage 1-2    898 larva L3 puffstage 3-6    1227 larva L3 puffstage 7-9    2326 white prepupae new    1917 white prepupae 12hr    984 white prepupae 24hr    1057 pupae 2d postWPP    567 pupae 3d postWPP    303 pupae 4d postWPP    372 adult male 01day    755 adult male 05day    687 adult male 30day    661 adult female 01day    556 adult female 05day    617 adult female 30day    647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0025693 expression level Developmental Stage   Expression Level embryo 00-02hr    567 embryo 02-04hr    382 embryo 04-06hr    254 embryo 06-08hr    528 embryo 08-10hr    867 embryo 10-12hr    1047 embryo 12-14hr    1295 embryo 14-16hr    629 embryo 16-18hr    928 embryo 18-20hr    796 embryo 20-22hr    1111 embryo 22-24hr    1526 larva L1    948 larva L2    1112 larva L3 12hr old    793 larva L3 puffstage 1-2    898 larva L3 puffstage 3-6    1227 larva L3 puffstage 7-9    2326 white prepupae new    1917 white prepupae 12hr    984 white prepupae 24hr    1057 pupae 2d postWPP    567 pupae 3d postWPP    303 pupae 4d postWPP    372 adult male 01day    755 adult male 05day    687 adult male 30day    661 adult female 01day    556 adult female 05day    617 adult female 30day    647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (567) embryo 02-04hr  (382) embryo 04-06hr  (254) embryo 06-08hr  (528) embryo 08-10hr  (867) embryo 10-12hr  (1047) embryo 12-14hr  (1295) embryo 14-16hr  (629) embryo 16-18hr  (928) embryo 18-20hr  (796) embryo 20-22hr  (1111) embryo 22-24hr  (1526) larva L1  (948) larva L2  (1112) larva L3 12hr old  (793) larva L3 puffstage 1-2  (898) larva L3 puffstage 3-6  (1227) larva L3 puffstage 7-9  (2326) white prepupae new  (1917) white prepupae 12hr  (984) white prepupae 24hr  (1057) pupae 2d postWPP  (567) pupae 3d postWPP  (303) pupae 4d postWPP  (372) adult male 01day  (755) adult male 05day  (687) adult male 30day  (661) adult female 01day  (556) adult female 05day  (617) adult female 30day  (647) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    567 embryo 02-04hr    382 embryo 04-06hr    254 embryo 06-08hr    528 embryo 08-10hr    867 embryo 10-12hr    1047 embryo 12-14hr    1295 embryo 14-16hr    629 embryo 16-18hr    928 embryo 18-20hr    796 embryo 20-22hr    1111 embryo 22-24hr  1526 larva L1    948 larva L2    1112 larva L3 12hr old    793 larva L3 puffstage 1-2    898 larva L3 puffstage 3-6    1227 larva L3 puffstage 7-9  2326 white prepupae new  1917 white prepupae 12hr    984 white prepupae 24hr    1057 pupae 2d postWPP    567 pupae 3d postWPP    303 pupae 4d postWPP    372 adult male 01day    755 adult male 05day    687 adult male 30day    661 adult female 01day    556 adult female 05day    617 adult female 30day    647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    567 embryo 02-04hr    382 embryo 04-06hr    254 embryo 06-08hr    528 embryo 08-10hr    867 embryo 10-12hr    1047 embryo 12-14hr    1295 embryo 14-16hr    629 embryo 16-18hr    928 embryo 18-20hr    796 embryo 20-22hr    1111 embryo 22-24hr    1526 larva L1    948 larva L2    1112 larva L3 12hr old    793 larva L3 puffstage 1-2    898 larva L3 puffstage 3-6    1227 larva L3 puffstage 7-9    2326 white prepupae new    1917 white prepupae 12hr    984 white prepupae 24hr    1057 pupae 2d postWPP    567 pupae 3d postWPP    303 pupae 4d postWPP    372 adult male 01day    755 adult male 05day    687 adult male 30day    661 adult female 01day    556 adult female 05day    617 adult female 30day    647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    567 embryo 02-04hr    382 embryo 04-06hr    254 embryo 06-08hr    528 embryo 08-10hr    867 embryo 10-12hr    1047 embryo 12-14hr    1295 embryo 14-16hr    629 embryo 16-18hr    928 embryo 18-20hr    796 embryo 20-22hr    1111 embryo 22-24hr    1526 larva L1    948 larva L2    1112 larva L3 12hr old    793 larva L3 puffstage 1-2    898 larva L3 puffstage 3-6    1227 larva L3 puffstage 7-9    2326 white prepupae new    1917 white prepupae 12hr    984 white prepupae 24hr    1057 pupae 2d postWPP    567 pupae 3d postWPP    303 pupae 4d postWPP    372 adult male 01day    755 adult male 05day    687 adult male 30day    661 adult female 01day    556 adult female 05day    617 adult female 30day    647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0025693    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0025693 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult fat body, adult spermathecae. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0025693 expression level Tissue   Expression Level Larval Central Nervous System    26.825 Larval Midgut    225.5 Larval Hindgut    102.8 Larval Malpighian Tubules    146.7 Larval Fat Body    97.3 Larval Salivary Gland    33.5 Larval Trachea    49.025 Larval Carcass    91.9 Adult Head    81.3 Adult Eye    55.3 Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    95 Adult Midgut    339.4 Adult Hindgut    117.5 Adult Malpighian Tubules    184.5 Adult Fat Body    100.4 Adult Salivary Gland no informative data Adult Heart    99.925 Adult VirginFemale Spermatheca    104.9 Adult InseminatedFemale Spermatheca    105 Adult Ovary    41.2 Adult Testis    44.5 Adult Male Accessory Gland no informative data Adult Carcass    98.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    26.825 Larval Midgut    225.5 Larval Hindgut    102.8 Larval Malpighian Tubules    146.7 Larval Fat Body    97.3 Larval Salivary Gland    33.5 Larval Trachea    49.025 Larval Carcass    91.9 Adult Head    81.3 Adult Eye    55.3 Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    95 Adult Midgut    339.4 Adult Hindgut    117.5 Adult Malpighian Tubules    184.5 Adult Fat Body    100.4 Adult Salivary Gland no informative data Adult Heart    99.925 Adult VirginFemale Spermatheca    104.9 Adult InseminatedFemale Spermatheca    105 Adult Ovary    41.2 Adult Testis    44.5 Adult Male Accessory Gland no informative data Adult Carcass    98.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    26.825 Larval Midgut    225.5 Larval Hindgut    102.8 Larval Malpighian Tubules    146.7 Larval Fat Body    97.3 Larval Salivary Gland    33.5 Larval Trachea    49.025 Larval Carcass    91.9 Adult Head    81.3 Adult Eye    55.3 Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    95 Adult Midgut    339.4 Adult Hindgut    117.5 Adult Malpighian Tubules    184.5 Adult Fat Body    100.4 Adult Salivary Gland no informative data Adult Heart    99.925 Adult VirginFemale Spermatheca    104.9 Adult InseminatedFemale Spermatheca    105 Adult Ovary    41.2 Adult Testis    44.5 Adult Male Accessory Gland no informative data Adult Carcass    98.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    26.825 Larval Midgut    225.5 Larval Hindgut    102.8 Larval Malpighian Tubules    146.7 Larval Fat Body    97.3 Larval Salivary Gland    33.5 Larval Trachea    49.025 Larval Carcass    91.9 Adult Head    81.3 Adult Eye    55.3 Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    95 Adult Midgut    339.4 Adult Hindgut    117.5 Adult Malpighian Tubules    184.5 Adult Fat Body    100.4 Adult Salivary Gland no informative data Adult Heart    99.925 Adult VirginFemale Spermatheca    104.9 Adult InseminatedFemale Spermatheca    105 Adult Ovary    41.2 Adult Testis    44.5 Adult Male Accessory Gland no informative data Adult Carcass    98.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0025693 expression level Tissue   Expression Level Larval Central Nervous System    26.825 Larval Midgut    225.5 Larval Hindgut    102.8 Larval Malpighian Tubules    146.7 Larval Fat Body    97.3 Larval Salivary Gland    33.5 Larval Trachea    49.025 Larval Carcass    91.9 Adult Head    81.3 Adult Eye    55.3 Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    95 Adult Midgut    339.4 Adult Hindgut    117.5 Adult Malpighian Tubules    184.5 Adult Fat Body    100.4 Adult Salivary Gland no informative data Adult Heart    99.925 Adult VirginFemale Spermatheca    104.9 Adult InseminatedFemale Spermatheca    105 Adult Ovary    41.2 Adult Testis    44.5 Adult Male Accessory Gland no informative data Adult Carcass    98.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    26.825 Larval Midgut    225.5 Larval Hindgut    102.8 Larval Malpighian Tubules    146.7 Larval Fat Body    97.3 Larval Salivary Gland    33.5 Larval Trachea    49.025 Larval Carcass    91.9 Adult Head    81.3 Adult Eye    55.3 Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    95 Adult Midgut    339.4 Adult Hindgut    117.5 Adult Malpighian Tubules    184.5 Adult Fat Body    100.4 Adult Salivary Gland no informative data Adult Heart    99.925 Adult VirginFemale Spermatheca    104.9 Adult InseminatedFemale Spermatheca    105 Adult Ovary    41.2 Adult Testis    44.5 Adult Male Accessory Gland no informative data Adult Carcass    98.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    26.825 Larval Midgut    225.5 Larval Hindgut    102.8 Larval Malpighian Tubules    146.7 Larval Fat Body    97.3 Larval Salivary Gland    33.5 Larval Trachea    49.025 Larval Carcass    91.9 Adult Head    81.3 Adult Eye    55.3 Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    95 Adult Midgut    339.4 Adult Hindgut    117.5 Adult Malpighian Tubules    184.5 Adult Fat Body    100.4 Adult Salivary Gland no informative data Adult Heart    99.925 Adult VirginFemale Spermatheca    104.9 Adult InseminatedFemale Spermatheca    105 Adult Ovary    41.2 Adult Testis    44.5 Adult Male Accessory Gland no informative data Adult Carcass    98.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    26.825 Larval Midgut    225.5 Larval Hindgut    102.8 Larval Malpighian Tubules    146.7 Larval Fat Body    97.3 Larval Salivary Gland    33.5 Larval Trachea    49.025 Larval Carcass    91.9 Adult Head    81.3 Adult Eye    55.3 Adult Brain    30.5 Adult Thoracic-Abdominal Ganglion    44.1 Adult Crop    95 Adult Midgut    339.4 Adult Hindgut    117.5 Adult Malpighian Tubules    184.5 Adult Fat Body    100.4 Adult Salivary Gland no informative data Adult Heart    99.925 Adult VirginFemale Spermatheca    104.9 Adult InseminatedFemale Spermatheca    105 Adult Ovary    41.2 Adult Testis    44.5 Adult Male Accessory Gland no informative data Adult Carcass    98.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    81.3   NA  Eye    55.3   NA  Brain    30.5   26.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    44.1   NA  Crop    95   225.5  Midgut    339.4   102.8  Hindgut    117.5   146.7  Malpighian Tubules    184.5   97.3  Fat Body    100.4   33.5  Salivary Gland    no informative data   NA  Heart    99.925   49.025  Trachea    NA   NA  VirginFemale Spermatheca    104.9   NA  InseminatedFemale Spermatheca    105   NA  Ovary    41.2   NA  Testis    44.5   NA  Male Accessory Gland    no informative data   91.9  Carcass    98.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025693 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11163-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG11163 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG11163EY09370 viable, with Scer\GAL4pnr-MD237 CG11163GD4522 Sterility Allele fertile CG11163EY09370 Phenotype manifest in Allele
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of CG11163 Class Mutagen Stocks Known lesion CG11163d00154 P-element activity 1 -- CG11163d05998 P-element activity 1 -- CG11163e00093 piggyBac transposase 1 -- CG11163EY09370 P-element activity 1 -- CG11163f02706 piggyBac transposase 1 -- CG11163KG00356 P-element activity 1 -- CG11163NP2750 1 -- CG11163UM-8239-3 1 -- CG11163e03772 piggyBac transposase 0 -- CG11163EP2070 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11163 Class Mutagen Stocks Known lesion CG11163GD4522 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11163JF03053 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11163KK111282 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4522} NA P{KK111282} NA P{TRiP.JF03053} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS3}CG11163UM-8239-3 NA P{SUPor-P}CG11163KG00356 NA PBac{RB}CG11163e00093 NA PBac{RB}CG11163e03772 NA PBac{WH}CG11163f02706 NA insertion of mobile activating element P{EP}CG11163EP2070 NA P{EPgy2}CG11163EY09370 NA P{XP}CG11163d00154 NA P{XP}CG11163d05998 NA insertion of enhancer trap binary system P{GawB}CG11163NP2750 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
zinc ion transmembrane transporter activity inferred from sequence or structural similarity with EMBL:AF003747 (FlyBase, 1992-)
Biological Process
CV term Evidence References
cation transport inferred from electronic annotation with InterPro:IPR002524 (FlyBase Curators et al., 2004-) transmembrane transport inferred from electronic annotation with InterPro:IPR002524 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR002524 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11163 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61419 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025693 DroID - A comprehensive database of gene and protein interactions. • FBgn0025693 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35513
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13836 Dere\GG10848 Dgri\GH20420 Dmoj\GI19603 Dper\GL20059 Dpse\GA24914 Dsec\GM16498 Dsim\GD10349 Dvir\GJ18417 Dwil\GK21764 Dyak\GE19441
Curated drosophilid orthologs	Dpse\GA10808
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011256-PA Aedes aegypti (mosquito) AGAP008982-PA Anopheles gambiae (mosquito) 199243 Branchiostoma floridae (lancelet) BGIBMGA014184-PA Bombyx mori (silk worm) CPIJ010101 Culex pipens (mosquito) NP_415273.1 Escherichia coli K12 (bacteria) ENSMUSP00000101500 Mus musculus (house mouse) 248347 Nematostella vectensis (starlet anemone) XP_974919.2 Tribolium castaneum (red flour beetle) Tc00.1047053510679.30 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511439.50 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000007337 Tetraodon nigroviridis (green spotted pufferfish) 26530 Thalassiosira pseudonana (marine diatom) ENSXETP00000047719 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0236784 FBgn0223749 FBgn0205576 FBgn0182121 FBgn0171413 FBgn0246297 FBgn0157654 FBgn0142340 FBgn0127883 FBgn0103153 FBgn0090863 CPIJ010101 BGIBMGA014184 AGAP008982 AAEL011256 AAEL008693 PHUM090400
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	28638 y1 v1; P{TRiP.JF03053}attP2 19952 y1 w67c23; P{EPgy2}CG11163EY09370 13098 y1 w67c23; P{SUPor-P}CG11163KG00356
Harvard	- P{XP}CG11163d00154 - P{XP}CG11163d05998 - PBac{RB}CG11163e00093 - PBac{WH}CG11163f02706
Kyoto	124436 w1118; P{RS3}CG11163UM-8239-3 104310 w*; P{GawB}CG11163NP2750 / CyO
VDRC	v107931 P{KK111282}VIE-260B v13311 w1118; P{GD4522}v13311
Genomic Clones ( 1 )
	BACR45O18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD05335
Other clones	DPiM_LD05335
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP21529 RE17368 RE18149 RE35961 RE37140 RE45470 RE45494 RE59680
Other clones	13209 14526 105372 117904 214247.48 CK01.44A.G5 CK01.63B.F4 CK01.86A.G8 CK01.114C.E8 CK01.130C.B4 CK01953 CK02137 EK037121 EK050241 EK051641 EK068060 EK100129 EK117010 EK157208 EK174029 EK231001 EK237136 EK290339 EP15140 FGH125C12 RP004033056 RP004236558 RP004243063 RP004303719 RP004508838
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025693 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35513
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: BEST:CK02137 CG11163 (Bayraktaroglu, 2000.11.2)
Additional comments
Other Comments
	Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis. (Kopczynski et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136341 NM_165446 NM_165447 NM_165448 RefSeq (Proteins) • NP_610185 NP_724429 NP_724430 NP_724431 DDBJ / EMBL / GenBank • AA141494 AA246577 AAF57308 AAL39485 AAM68358 AAM68359 AAM68360 AW941584 AY069340 AZ300926 BH610063 CL632187 CZ471414 CZ474861 CZ477998 CZ481525 CZ481526 CZ485255 CZ485256 Entrez Gene - A searchable database of RefSeq genes. • 35513 UniProtKB/TrEMBL • Q8T0G1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cation efflux protein (IPR002524)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61419 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025693 DroID - A comprehensive database of gene and protein interactions. • FBgn0025693 DRSC - Results from RNAi screens. • FBgn0025693 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025693 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11163-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025693 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35513 InParanoid A subset of ortholog calls from InParanoid. • AAEL011256-PA Aedes aegypti (mosquito) AGAP008982-PA Anopheles gambiae (mosquito) 199243 Branchiostoma floridae (lancelet) BGIBMGA014184-PA Bombyx mori (silk worm) CPIJ010101 Culex pipens (mosquito) NP_415273.1 Escherichia coli K12 (bacteria) ENSMUSP00000101500 Mus musculus (house mouse) 248347 Nematostella vectensis (starlet anemone) XP_974919.2 Tribolium castaneum (red flour beetle) Tc00.1047053510679.30 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511439.50 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000007337 Tetraodon nigroviridis (green spotted pufferfish) 26530 Thalassiosira pseudonana (marine diatom) ENSXETP00000047719 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35513 modMine - Data generated by the modENCODE project. • FBgn0025693 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0236784 FBgn0223749 FBgn0205576 FBgn0182121 FBgn0171413 FBgn0246297 FBgn0157654 FBgn0142340 FBgn0127883 FBgn0103153 FBgn0090863 CPIJ010101 BGIBMGA014184 AGAP008982 AAEL011256 AAEL008693 PHUM090400
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BEST:CK02137 (Giot et al., 2003, ) CG11163 (Wang et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009) CK02137 (Kopczynski et al., 1998)
Name Synonym
Secondary FlyBase IDs
	FBgn0033040
References ( 20 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Wang et al., 2009, FASEB J. 23(8): 2650--2661 Dietary zinc absorption is mediated by ZnT1 in Drosophila melanogaster. [FBrf0208447] Corradini et al., 2003, Chromosoma 112(1): 26--37 FISH analysis of Drosophila melanogaster heterochromatin using BACs and P elements. [FBrf0160459] Kopczynski et al., 1998, Proc. Natl. Acad. Sci. USA 95(17): 9973--9978 A high throughput screen to identify secreted and transmembrane proteins involved in Drosophila embryogenesis. [FBrf0104467]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Bayraktaroglu, 2000.11.2, Current list of possibly CG-able known genes. Current list of possibly CG-able known genes. [FBrf0131225]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Ketchum, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126677]