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Gene Dmel\unc-13

General Information
Symbol	Dmel\unc-13	Species	D. melanogaster
Name	unc-13	Annotation symbol	CG2999
Feature type	protein_coding_gene	FlyBase ID	FBgn0025726
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	DUNC-13
Genomic Location
Chromosome (arm)	4	Recombination map	4-
Cytogenetic map	102E5-102F1	Sequence location	4:888,450..925,447 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene unc-13 is referred to in FlyBase by the symbol Dmel\unc-13 (CG2999, FBgn0025726). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: diacylglycerol binding. There is experimental evidence that it is involved in the biological process: synaptic transmission; synaptic vesicle exocytosis. 10 alleles are reported. The phenotype of these alleles is annotated with: synaptic vesicle. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 domain; C2 membrane targeting protein; Calcium-dependent secretion activator; Mammalian uncoordinated homology 13, domain 2; Mammalian uncoordinated homology 13, subgroup, domain 2; Munc13 homology 1; Protein kinase C-like, phorbol ester/diacylglycerol binding; Uncoordinated protein 13 (Unc-13). Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, adult heart, adult fat body, virgin spermatheca, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635684_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of unc-13. Gene sequence location is 4:888450..925447.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 102E5-102F1
Experimentally Determined Cytological Location
Cytogenetic map Notes References 102D-102D   (determined by in situ hybridisation)   (Hirsh, 1991.11.1) 102D3-102D4     (Aravamudan, 1999.7.14) 102D3-102D4     (Montell, 1998.8.11) 102D3-102D4   (determined by in situ hybridisation)   (Aravamudan et al., 1999) 102D3-102D4   (determined by in situ hybridisation)   (Xu et al., 1998) 102D-102D   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location	4-
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\unc-13 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) unc-13-RA FBtr0089245  NM_143692   9769   2871 unc-13-RB FBtr0089247  NM_166794   10276   3183 unc-13-RC FBtr0089246  NM_166793   9778   2874 unc-13-RD FBtr0308805  NM_001258497   12808   2871 unc-13-RE FBtr0308806  NM_001258498   10285   3186 unc-13-RF FBtr0334487  NM_001272146   9289   2711
Additional Transcript Data & Comments
Reported size (kB)	12, 4, 3.3, 2.4 (northern blot) (Xu et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein unc-13-PA   FBpp0088305   320.3   2871   4.98     NP_651949   AAN06592 unc-13-PB   FBpp0088307   360.1   3183   6.31     NP_726615   AAN06593 unc-13-PC   FBpp0088306   320.5   2874   5.07     NP_726614   AAF59405 unc-13-PD   FBpp0300962   320.3   2871   4.98     NP_001245426   AFH06786 unc-13-PE   FBpp0300963   360.4   3186   6.33     NP_001245427   AFH06787 unc-13-PF   FBpp0306555   302.7   2711   4.84     NP_001259075   AGB96565
Additional Polypeptide Data & Comments
Reported size (kDa)	1724, 1304 (aa) (Xu et al., 1998)
Comments	Gel overlay and pul-down assays were used to demonstrate that unc-13 protein binds calmodulin. This binding was mapped to residues 64-88. Binding was Ca2+-dependent in gel-overlay assays, but was Ca2+-independent in solution. (Xu et al., 1998) Gel overlay and pul-down assays were used to demonstrate that unc-13 protein binds calmodulin. This binding was mapped to residues 64-88 of the A type unc-13 protein. Binding was Ca2+-dependent in gel-overlay assays, but was Ca2+-independent in solution. (Xu et al., 1998)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • C2 membrane targeting protein (IPR018029) C2 calcium-dependent membrane targeting (IPR000008) Protein kinase C-like, phorbol ester/diacylglycerol binding (IPR002219) C2 calcium/lipid-binding domain, CaLB (IPR008973) Calcium-dependent secretion activator (IPR010439) Munc13 homology 1 (IPR014770) Mammalian uncoordinated homology 13, domain 2 (IPR014772) Mammalian uncoordinated homology 13, subgroup, domain 2 (IPR019558) Uncoordinated protein 13 (Unc-13) (IPR027080) C2 domain (IPR020477)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202809   AA263799   AA391789   AA440536   AA440630   AA539134   AA541106   AA541127   AA567547   AA567783   AA698143   AA803910   AA950388   AE014135 AAF59405   AE014135 AAN06592   AE014135 AAN06593   AC010916   AF169141 AAF22962   AF433740   AF433741   AF433742   AF433743   AF433744   AF433745   AF433746   AF433747   AF433748   AF433749   AE014135 AFH06786   AE014135 AFH06787   AE014135 AGB96565   AI062910   AI256900   AI259936   AW942359   AW942917   AY069559 AAL39704   AY094789 AAM11142   BG637877   BG637990   BG638129   BG638137   BG638246   BI230381   BI230688   BI238216   BI485414   BI485859   BI578934   BT082068   BT100277   CA805872   CA806603   CK131180   CO177056   CO177729   CO178458   CO179013   CO186397   CO187655   CO190035   CO190060   CO190077   CO190572   CO192845   CO194504   CO196482   CO261875   CO262406   CO262833   CO262964   CO264907   CO266573   CO267257   CO267722   CO268369   CO268625   CO269798   CO270410   CO270981   CO271106   CO272090   CO272399   CO273068   CO277195   CO277810   CO278207   CO279567   CO279805   CO279972   CO280403   CO281437   CO282351   CO283837   CO284022   CO284513   CO284800   CO284807   CO286869   CO287135   CO287668   CO287916   CO289118   CO289603   CO290852   CO290944   CO291333   CO293185   CO295451   CO296240   CO297795   CO298060   CO298625   CO299818   CO299852   CO301418   CO301585   CO302786   CO303178   CO304322   CO304659   CO308012   CO308246   CO309746   CO311544   CO311751   CO312138   CO312275   CO313501   CO315083   CO315932   CO316199   CO316390   CO317496   CO318298   CO318807   CO319765   CO320082   CO320691   CO321366   CO321638   CO322979   CO323175   CO324824   CO326016   CO326838   CO327069   CO329232   CO329781   CO332612   CO333874   CO338954   CO339121   CO340032   CO341093   CO341663   CO342210   CO342405   CO342641   CO344868   CO345279   CO345576   CZ489839   CZ489840   EC052141   EC053225   EC053634   EC054129   EC054216   EC054668   EC055395   EC055396   EC055397   EC055398   EC056807   EC057287   EC057321   EC058088   EC058615   EC058765   EC059438   EC060145   EC060306   EC062271   EC062678   EC063404   EC063980   EC064793   EC065705   EC066481   EC067130   EC067259   EC067978   EC069612   EC069692   EC070049   EC070432   EC070651   EC070941   EC071076   EC071417   EC072373   EC072569   EC072600   EC073405   EC074015   EC074436   EC074862   EC075366   EC076780   EC077612   EC078382   EC079870   EC080121   EC080834   EC083167   EC084647   EC084771   EC084971   EC085951   EC088419   EC088500   EC089727   EC089807   EC089825   EC089955   EC090178   EC194718   EC196068   EC196482   EC196765   EC198572   EC198598   EC199144   EC199250   EC199778   EC200028   EC200641   EC200653   EC200730   EC201436   EC201653   EC202281   EC202838   EC204352   EC206038   EC207168   EC207261   EC208288   EC208753   EC209633   EC210993   EC211079   EC213074   EC213565   EC214167   EC215267   EC217077   EC218252   EC218253   EC219713   EC220578   EC220757   EC222601   EC222770   EC224222   EC224825   EC225325   EC225640   EC225661   EC227308   EC227836   EC228106   EC228118   EC228224   EC228714   EC230697   EC230955   EC231160   EC231470   EC231761   EC232977   EC233690   EC234149   EC238642   EC239391   EC239899   EC240219   EC241645   EC242118   EC242406   EC242571   EC243266   EC243719   EC244436   EC244913   EC246136   EC246164   EC246416   EC246606   EC247338   EC247874   EC248114   EC248301   EC250253   EC251356   EC251659   EC252251   EC254087   EC256078   EC257177   EC257773   EC258644   EC258690   EC258737   EC260183   EC260774   EL875272   EL875273   EL884115   EL884243   EL884244   EV595824   EV596753   GH945675   GH948416   GH949945   GH950001   GH950154   GH953196   GH953511   GH955228   GH957092   GH957822   GH958182   GH958250   GH959415   GH961102   GH961326   GH961369   GH966480   GH966624   GH966982   GH967376   GH969900   GH970432   GH970944   GH971078   GH971148   GH974342   GH974729   GH976019   GH977999   GH980317   GH982387   GH983653   GH984337   GH984402   GH984702   Y17921 CAA76941   Y17922 CAA76942
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	H9XVP2 Q8IM86 Q8IM87 Q9V483 Q9U4K9 O96959 O96960 Q8T049 Q8SX82
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 17   presumptive embryonic/larval central nervous system   (Aravamudan et al., 1999) embryonic stage 12 -- 17   presumptive embryonic/larval peripheral nervous system   (Aravamudan et al., 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference pupal stage     (Xu et al., 1998) adult stage   adult head   (Xu et al., 1998)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval neuromuscular junction | subset   (Aravamudan and Broadie, 2003) third instar larval stage   embryonic/larval neuromuscular junction | subset   (Aravamudan and Broadie, 2003) type I bouton   • presynaptic membrane (Aravamudan and Broadie, 2003) type I bouton   • postsynaptic membrane (Aravamudan and Broadie, 2003) ventral nerve cord | restricted   (Aravamudan and Broadie, 2003) embryonic/larval brain | restricted   (Aravamudan and Broadie, 2003) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
postsynaptic membrane inferred from direct assay (Aravamudan and Broadie, 2003) terminal bouton inferred from direct assay (Aravamudan and Broadie, 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, adult heart, adult fat body, virgin spermatheca, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    822.05 Larval Midgut    21.3 Larval Hindgut    25.6 Larval Malpighian Tubules    13.8 Larval Fat Body    24.5 Larval Salivary Gland    43.3 Larval Trachea    93.85 Larval Carcass    35.775 Adult Head    422.7 Adult Eye    521.1 Adult Brain    2184.2 Adult Thoracic-Abdominal Ganglion    1621.2 Adult Crop    152.2 Adult Midgut    30.8 Adult Hindgut    81.4 Adult Malpighian Tubules    13.4 Adult Fat Body    110.4 Adult Salivary Gland    31.4 Adult Heart    136 Adult VirginFemale Spermatheca    126.2 Adult InseminatedFemale Spermatheca    90.3 Adult Ovary    88.7 Adult Testis    24.9 Adult Male Accessory Gland    41.4 Adult Carcass    100.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (822.05) Larval Midgut    21.3 Larval Hindgut    25.6 Larval Malpighian Tubules    13.8 Larval Fat Body    24.5 Larval Salivary Gland    43.3 Larval Trachea    93.85 Larval Carcass    35.775 Adult Head    422.7 Adult Eye  521.1 Adult Brain  (2184.2) Adult Thoracic-Abdominal Ganglion  (1621.2) Adult Crop    152.2 Adult Midgut    30.8 Adult Hindgut    81.4 Adult Malpighian Tubules    13.4 Adult Fat Body    110.4 Adult Salivary Gland    31.4 Adult Heart    136 Adult VirginFemale Spermatheca    126.2 Adult InseminatedFemale Spermatheca    90.3 Adult Ovary    88.7 Adult Testis    24.9 Adult Male Accessory Gland    41.4 Adult Carcass    100.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    822.05 Larval Midgut    21.3 Larval Hindgut    25.6 Larval Malpighian Tubules    13.8 Larval Fat Body    24.5 Larval Salivary Gland    43.3 Larval Trachea    93.85 Larval Carcass    35.775 Adult Head    422.7 Adult Eye    521.1 Adult Brain  (2184.2) Adult Thoracic-Abdominal Ganglion  (1621.2) Adult Crop    152.2 Adult Midgut    30.8 Adult Hindgut    81.4 Adult Malpighian Tubules    13.4 Adult Fat Body    110.4 Adult Salivary Gland    31.4 Adult Heart    136 Adult VirginFemale Spermatheca    126.2 Adult InseminatedFemale Spermatheca    90.3 Adult Ovary    88.7 Adult Testis    24.9 Adult Male Accessory Gland    41.4 Adult Carcass    100.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    822.05 Larval Midgut    21.3 Larval Hindgut    25.6 Larval Malpighian Tubules    13.8 Larval Fat Body    24.5 Larval Salivary Gland    43.3 Larval Trachea    93.85 Larval Carcass    35.775 Adult Head    422.7 Adult Eye    521.1 Adult Brain    2184.2 Adult Thoracic-Abdominal Ganglion    1621.2 Adult Crop    152.2 Adult Midgut    30.8 Adult Hindgut    81.4 Adult Malpighian Tubules    13.4 Adult Fat Body    110.4 Adult Salivary Gland    31.4 Adult Heart    136 Adult VirginFemale Spermatheca    126.2 Adult InseminatedFemale Spermatheca    90.3 Adult Ovary    88.7 Adult Testis    24.9 Adult Male Accessory Gland    41.4 Adult Carcass    100.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    822.05 Larval Midgut    21.3 Larval Hindgut    25.6 Larval Malpighian Tubules    13.8 Larval Fat Body    24.5 Larval Salivary Gland    43.3 Larval Trachea    93.85 Larval Carcass    35.775 Adult Head    422.7 Adult Eye    521.1 Adult Brain    2184.2 Adult Thoracic-Abdominal Ganglion    1621.2 Adult Crop    152.2 Adult Midgut    30.8 Adult Hindgut    81.4 Adult Malpighian Tubules    13.4 Adult Fat Body    110.4 Adult Salivary Gland    31.4 Adult Heart    136 Adult VirginFemale Spermatheca    126.2 Adult InseminatedFemale Spermatheca    90.3 Adult Ovary    88.7 Adult Testis    24.9 Adult Male Accessory Gland    41.4 Adult Carcass    100.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (822.05) Larval Midgut    21.3 Larval Hindgut    25.6 Larval Malpighian Tubules    13.8 Larval Fat Body    24.5 Larval Salivary Gland    43.3 Larval Trachea    93.85 Larval Carcass    35.775 Adult Head    422.7 Adult Eye  521.1 Adult Brain  (2184.2) Adult Thoracic-Abdominal Ganglion  (1621.2) Adult Crop    152.2 Adult Midgut    30.8 Adult Hindgut    81.4 Adult Malpighian Tubules    13.4 Adult Fat Body    110.4 Adult Salivary Gland    31.4 Adult Heart    136 Adult VirginFemale Spermatheca    126.2 Adult InseminatedFemale Spermatheca    90.3 Adult Ovary    88.7 Adult Testis    24.9 Adult Male Accessory Gland    41.4 Adult Carcass    100.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    822.05 Larval Midgut    21.3 Larval Hindgut    25.6 Larval Malpighian Tubules    13.8 Larval Fat Body    24.5 Larval Salivary Gland    43.3 Larval Trachea    93.85 Larval Carcass    35.775 Adult Head    422.7 Adult Eye    521.1 Adult Brain  (2184.2) Adult Thoracic-Abdominal Ganglion  1621.2 Adult Crop    152.2 Adult Midgut    30.8 Adult Hindgut    81.4 Adult Malpighian Tubules    13.4 Adult Fat Body    110.4 Adult Salivary Gland    31.4 Adult Heart    136 Adult VirginFemale Spermatheca    126.2 Adult InseminatedFemale Spermatheca    90.3 Adult Ovary    88.7 Adult Testis    24.9 Adult Male Accessory Gland    41.4 Adult Carcass    100.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    822.05 Larval Midgut    21.3 Larval Hindgut    25.6 Larval Malpighian Tubules    13.8 Larval Fat Body    24.5 Larval Salivary Gland    43.3 Larval Trachea    93.85 Larval Carcass    35.775 Adult Head    422.7 Adult Eye    521.1 Adult Brain    2184.2 Adult Thoracic-Abdominal Ganglion    1621.2 Adult Crop    152.2 Adult Midgut    30.8 Adult Hindgut    81.4 Adult Malpighian Tubules    13.4 Adult Fat Body    110.4 Adult Salivary Gland    31.4 Adult Heart    136 Adult VirginFemale Spermatheca    126.2 Adult InseminatedFemale Spermatheca    90.3 Adult Ovary    88.7 Adult Testis    24.9 Adult Male Accessory Gland    41.4 Adult Carcass    100.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    422.7   NA  Eye    521.1   NA  Brain    2184.2   822.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1621.2   NA  Crop    152.2   21.3  Midgut    30.8   25.6  Hindgut    81.4   13.8  Malpighian Tubules    no informative data   24.5  Fat Body    110.4   43.3  Salivary Gland    31.4   NA  Heart    136   93.85  Trachea    NA   NA  VirginFemale Spermatheca    126.2   NA  InseminatedFemale Spermatheca    90.3   NA  Ovary    88.7   NA  Testis    24.9   NA  Male Accessory Gland    41.4   35.775  Carcass    100.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    35 central nervous system, pupae P8    89 head, virgin 1-day female    34 head, virgin 4-day female    28 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    25 head, mated 20-day female    18 head, mated 1-day male    45 head, mated 4-day male    47 head, mated 20-day male    44 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    13 carcass, larvae L3 wandering    8 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    16 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3  (35) central nervous system, pupae P8  (89) head, virgin 1-day female  (34) head, virgin 4-day female  (28) head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    25 head, mated 20-day female    18 head, mated 1-day male  (45) head, mated 4-day male  (47) head, mated 20-day male  (44) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    13 carcass, larvae L3 wandering    8 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    16 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    35 central nervous system, pupae P8    89 head, virgin 1-day female    34 head, virgin 4-day female    28 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    25 head, mated 20-day female    18 head, mated 1-day male    45 head, mated 4-day male    47 head, mated 20-day male    44 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    13 carcass, larvae L3 wandering    8 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    16 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    35 central nervous system, pupae P8    89 head, virgin 1-day female    34 head, virgin 4-day female    28 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    25 head, mated 20-day female    18 head, mated 1-day male    45 head, mated 4-day male    47 head, mated 20-day male    44 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    13 carcass, larvae L3 wandering    8 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    16 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    35 central nervous system, pupae P8    89 head, virgin 1-day female    34 head, virgin 4-day female    28 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    25 head, mated 20-day female    18 head, mated 1-day male    45 head, mated 4-day male    47 head, mated 20-day male    44 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    13 carcass, larvae L3 wandering    8 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    16 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3  (35) central nervous system, pupae P8  (89) head, virgin 1-day female  (34) head, virgin 4-day female  28 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    25 head, mated 20-day female    18 head, mated 1-day male  (45) head, mated 4-day male  (47) head, mated 20-day male  (44) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    13 carcass, larvae L3 wandering    8 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    16 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    35 central nervous system, pupae P8    89 head, virgin 1-day female    34 head, virgin 4-day female    28 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    25 head, mated 20-day female    18 head, mated 1-day male    45 head, mated 4-day male    47 head, mated 20-day male    44 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    13 carcass, larvae L3 wandering    8 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    16 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    35 central nervous system, pupae P8    89 head, virgin 1-day female    34 head, virgin 4-day female    28 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    25 head, mated 20-day female    18 head, mated 1-day male    45 head, mated 4-day male    47 head, mated 20-day male    44 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    13 carcass, larvae L3 wandering    8 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    16 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    4 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    15 larva L1    7 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    23 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    8 adult male 30day    7 adult female 01day    5 adult female 05day    9 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    4 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    15 larva L1    7 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    23 pupae 2d postWPP  (29) pupae 3d postWPP    17 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    8 adult male 30day    7 adult female 01day    5 adult female 05day    9 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    4 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    15 larva L1    7 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    23 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    8 adult male 30day    7 adult female 01day    5 adult female 05day    9 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    4 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    15 larva L1    7 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    23 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    8 adult male 30day    7 adult female 01day    5 adult female 05day    9 adult female 30day    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    4 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    15 larva L1    7 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    23 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    8 adult male 30day    7 adult female 01day    5 adult female 05day    9 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    4 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    15 larva L1    7 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    23 pupae 2d postWPP  29 pupae 3d postWPP    17 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    8 adult male 30day    7 adult female 01day    5 adult female 05day    9 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    4 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    15 larva L1    7 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    23 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    8 adult male 30day    7 adult female 01day    5 adult female 05day    9 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    6 embryo 04-06hr    4 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    4 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    9 embryo 22-24hr    15 larva L1    7 larva L2    4 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    23 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    8 adult male 30day    7 adult female 01day    5 adult female 05day    9 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    3 embryonic 1182-4H    21 embryonic GM2    27 embryonic Kc167    6 embryonic S1    5 embryonic S3    10 leg disc CME L1    3 wing disc CME-W2    24 wing disc ML-DmD8    17 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    37 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    25 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    3 embryonic 1182-4H    21 embryonic GM2  (27) embryonic Kc167    6 embryonic S1    5 embryonic S3    10 leg disc CME L1    3 wing disc CME-W2    24 wing disc ML-DmD8    17 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11  (37) antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    25 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    3 embryonic 1182-4H    21 embryonic GM2    27 embryonic Kc167    6 embryonic S1    5 embryonic S3    10 leg disc CME L1    3 wing disc CME-W2    24 wing disc ML-DmD8    17 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    37 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    25 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    3 embryonic 1182-4H    21 embryonic GM2    27 embryonic Kc167    6 embryonic S1    5 embryonic S3    10 leg disc CME L1    3 wing disc CME-W2    24 wing disc ML-DmD8    17 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    37 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    25 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    3 embryonic 1182-4H    21 embryonic GM2    27 embryonic Kc167    6 embryonic S1    5 embryonic S3    10 leg disc CME L1    3 wing disc CME-W2    24 wing disc ML-DmD8    17 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    37 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    25 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    3 embryonic 1182-4H    21 embryonic GM2  27 embryonic Kc167    6 embryonic S1    5 embryonic S3    10 leg disc CME L1    3 wing disc CME-W2    24 wing disc ML-DmD8    17 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11  (37) antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    25 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    3 embryonic 1182-4H    21 embryonic GM2    27 embryonic Kc167    6 embryonic S1    5 embryonic S3    10 leg disc CME L1    3 wing disc CME-W2    24 wing disc ML-DmD8    17 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    37 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    25 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    3 embryonic 1182-4H    21 embryonic GM2    27 embryonic Kc167    6 embryonic S1    5 embryonic S3    10 leg disc CME L1    3 wing disc CME-W2    24 wing disc ML-DmD8    17 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    37 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    25 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025726 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2999-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal unc-13P84200 lethal, with Scer\GAL4elav.PLu unc-13GD9877 lethal | late embryonic stage | recessive unc-13P84200 viable unc-13f07072 viable, with Scer\GAL4pnr-MD237 unc-13GD9877 Sterility Allele fertile unc-13f07072 Other Phenotypes Allele neuroanatomy defective unc-13unspecified neurophysiology defective | recessive unc-13P84200 paralytic | recessive unc-13P84200 Phenotype manifest in Allele synaptic vesicle unc-13unspecified
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of unc-13 Class Mutagen Stocks Known lesion unc-13f07072 piggyBac transposase 2 -- unc-13GJ P-element activity 2 Yes unc-13MI00468 1 -- unc-13P84200 loss of function allele P-element activity 1 Yes unc-13f07073 piggyBac transposase 0 -- unc-13unspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of unc-13 Class Mutagen Stocks Known lesion unc-13GD9877 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes unc-13JF02440 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes unc-13KK109346 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes unc-13NIG.2999R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9877} NA P{KK109346} NA P{NIG.2999R} NA P{TRiP.JF02440} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}unc-13MI00468 NA P{ActGFP}unc-13GJ NA P{ry11}unc-13P84200 NA PBac{WH}unc-13f07072 NA PBac{WH}unc-13f07073 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
synaptic transmission inferred from mutant phenotype (Aravamudan et al., 1999) synaptic vesicle exocytosis inferred from mutant phenotype (Aravamudan et al., 1999)
Cellular Component
CV term Evidence References
postsynaptic membrane inferred from direct assay (Aravamudan and Broadie, 2003) terminal bouton inferred from direct assay (Aravamudan and Broadie, 2003)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
calmodulin binding traceable author statement (Montell, 1999) diacylglycerol binding inferred from sequence or structural similarity with InterPro:IPR002219 (FlyBase, 1992-)
Biological Process
CV term Evidence References
intracellular signal transduction inferred from electronic annotation with InterPro:IPR002219 (FlyBase Curators et al., 2004-) neurotransmitter secretion non-traceable author statement (Lloyd et al., 2000) synaptic transmission non-traceable author statement (Aravamudan, 1999.7.14) synaptic vesicle exocytosis inferred from sequence or structural similarity (Littleton, 2000) synaptic vesicle priming non-traceable author statement (Lloyd et al., 2000)
Cellular Component
CV term Evidence References
synaptic vesicle inferred from sequence or structural similarity (Littleton, 2000) non-traceable author statement (Lloyd et al., 2000)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions unc-13 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68665 DroID - A comprehensive database of gene and protein interactions. • FBgn0025726 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43841
Orthologs
OrthoDB Orthologs (158) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6N3176 Dipteran inclusive ortholog search EOG6NGGVM Insect inclusive ortholog search EOG68PKF0 Arthropod inclusive ortholog search EOG62V6X1 Metazoa inclusive ortholog search EOG6TFCC5
Orthologs in Drosophila Species (EOG6N3176)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\unc-13     Drosophila simulans   Dsim\unc-13     Drosophila sechellia   Dsec\GM26765     Drosophila erecta   Dere\GG16431     Drosophila yakuba   Dyak\GE14499 Y   Drosophila ananassae   Dana\GF19013 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA23268     Drosophila persimilis   Dper\GL15609 Y   Drosophila willistoni   Dwil\GK20909     Drosophila willistoni   Dwil\GK13659 Y   Drosophila virilis   Dvir\GJ18433 Y   Drosophila mojavensis   Dmoj\GI14058 Y   Drosophila grimshawi   Dgri\GH24009 Y
Orthologs in non-Drosophila Dipterans (EOG6NGGVM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002357   Anopheles gambiae Malaria mosquito  Agam\AGAP000065   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006394
Orthologs in non-Dipteran Insects (EOG68PKF0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB48517   Apis mellifera Western honey bee  Amel\GB48515   Apis mellifera Western honey bee  Amel\GB48518   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG017218   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG017227   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG033938   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26926   Atta cephalotes Leafcutter ant  Acep\ACEP16775   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20678   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19626   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19625   Linepithema humile Argentine ant  Lhum\LH24253   Linepithema humile Argentine ant  Lhum\LH24254   Linepithema humile Argentine ant  Lhum\LH24257   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20122   Solenopsis invicta Red fire ant  Sinv\SINV16356   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000421   Bombyx mori Silkmoth  Bmor\BGIBMGA001566   Pediculus humanus Human body louse  Phum\PHUM432200   Pediculus humanus Human body louse  Phum\PHUM432180   Tribolium castaneum Red flour beetle  Tcas\TC004071
Orthologs in non-Insect Arthropods (EOG62V6X1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Msln   Ixodes scapularis Deer tick  Isca\ISCW023875
Orthologs in non-Arthropod Metazoa (EOG6TFCC5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ZK524.2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015580gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016776gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020524gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016892gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007116gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026176gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004373gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007287gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005588gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007017gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022484gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010446gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011955gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027050gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013476gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004565gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025444gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016474gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004894gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023977gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026068gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020241gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013730gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017315gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025794gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026831gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016929gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027597gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015491gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003503gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014394gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016966gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020165gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006194gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006551gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018386gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007412gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009245gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024506gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009322gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011010gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026728gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006965gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022547gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007413gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024433gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010134gn   Danio rerio Zebrafish  Drer\CR356223.2   Danio rerio Zebrafish  Drer\ENSDARG00000087214   Danio rerio Zebrafish  Drer\ENSDARG00000091804   Danio rerio Zebrafish  Drer\ENSDARG00000091647   Danio rerio Zebrafish  Drer\CR855996.2   Danio rerio Zebrafish  Drer\ENSDARG00000088978   Danio rerio Zebrafish  Drer\ENSDARG00000088608   Danio rerio Zebrafish  Drer\ENSDARG00000036829   Danio rerio Zebrafish  Drer\ENSDARG00000077273   Danio rerio Zebrafish  Drer\ENSDARG00000087317   Danio rerio Zebrafish  Drer\unc13c   Danio rerio Zebrafish  Drer\si:ch73-6o20.1   Danio rerio Zebrafish  Drer\si:dkey-110c1.7   Danio rerio Zebrafish  Drer\ENSDARG00000053220   Danio rerio Zebrafish  Drer\CABZ01117756.1   Danio rerio Zebrafish  Drer\AL929239.1   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030736   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032622   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031163   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033007   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000034281   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030555   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031791   Xenopus tropicalis Western clawed frog  Xtro\unc13a   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031854   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000034062   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033773   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033316   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030411   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032227   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031146   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000034022   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031349   Xenopus tropicalis Western clawed frog  Xtro\unc13c   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030317   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030830   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033192   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032298   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000034166   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033991   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000034339   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032795   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031048   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000013987   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030561   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031562   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031029   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031641   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030928   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031290   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000034246   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031876   Gallus gallus Domestic chicken  Ggal\UNC13B   Gallus gallus Domestic chicken  Ggal\UNC13C   Mus musculus House mouse  Mmus\Unc13a   Mus musculus House mouse  Mmus\Unc13c   Mus musculus House mouse  Mmus\ENSMUSG00000028456   Mus musculus House mouse  Mmus\L1td1   Mus musculus House mouse  Mmus\ENSMUSG00000091447   Rattus norvegicus Norway rat  Rnor\LOC100361014   Rattus norvegicus Norway rat  Rnor\Unc13b   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000039721   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029346   Rattus norvegicus Norway rat  Rnor\Unc13a   Rattus norvegicus Norway rat  Rnor\Unc13c   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000003355   Rattus norvegicus Norway rat  Rnor\LOC317588   Homo sapiens Human  Hsap\L1TD1   Homo sapiens Human  Hsap\UNC13C   Homo sapiens Human  Hsap\UNC13A   Homo sapiens Human  Hsap\UNC13B
Human Orthologs (4)
Gene OMIM HGNC Hsap\L1TD1     Hsap\UNC13C     Hsap\UNC13A     Hsap\UNC13B
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15473 Drosophila yakuba Dyak\GE14499 Drosophila ananassae Dana\GF19013 Drosophila persimilis Dper\GL15609 Drosophila willistoni Dwil\GK13659 Drosophila virilis Dvir\GJ18433 Drosophila mojavensis Dmoj\GI14058 Drosophila grimshawi Dgri\GH24009
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	4759 pan2/P{ActGFP}unc-13GJ 19037 w1118; PBac{WH}unc-13f07072 29548 y1 v1; P{TRiP.JF02440}attP2 9549 w1118; P{ActGFP}unc-13GJ/In(4)ciD, ciD panciD 31015 y1 w*; Mi{MIC}unc-13MI00468/In(4)ciD, ciD panciD
Harvard	- PBac{WH}unc-13f07072
Kyoto	101911 ry506 ; P{ry11}unc-13P84200 / ciD
VDRC	v101383 P{KK109346}VIE-260B v33606 w1118; P{GD9877}v33606 v33609 w1118; P{GD9877}v33609/TM3
Genomic Clones ( 2 )
	BACR11A04 BACR16N23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 322 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD15472 LD28927 RE69264
Other clones	IP15377
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02281 GH09925 GM10807 HL01436 HL01763 HL03841 LD03127 LD15345 LD17135 LD20909 LP03463 LP03615 RE10179 RE14712 RE34616 RE68733 RE69209 RE72882
Other clones	134 1709 2068 7627 8060 9797 15797 16479 16896 17241 17280 28211 29968.1 30837 35731 37408 38237 38351 38845 40166 42275 44023 45867 47067 47191 50508 50549 50898 52258 54950 55316 56979 58414 58784 61069 61922 61984 63422 63526 64346 64593 67046 67190 73262 76089 76373 76674 76682 79707 80793 81680 84415 101313 101507 101534 102230 102699 103738 106796 107131 108801 109067 109146 119287 120377 122066 153003 160387 160947 163727 167428 173679 173822 174025 174047 176113 177286 182741 190193 191426 191436 214243.2 214251.11 214277.6 214281.5 214289.7 214311.4 214467.5 214469.4 214475.5 214503.6 214533.6 273710 273954 277232 282224 282369 283621 CK01.6B.F2 CK01.8D.E12 CK01.13C.C10 CK01.13D.C10 CK01.15A.F4 CK01.20D.B8 CK01.57A.G12 CK01.57D.E2 CK01.61C.G2 CK01.64B.E5 CK01.64B.E7 CK01.67B.B6 CK01.70B.D6 CK01.71C.E6 CK01.81C.C9 CK01.83B.C8 CK01.84C.G8 CK01.89B.D6 CK01.91B.C4 CK01.91B.G4 CK01.97A.G12 CK01.97C.F9 CK01.101A.F8 CK01.102D.G6 CK01.103C.B2 CK01.106B.A10 CK01.108A.F4 CK01.109B.C5 CK01.110B.A2 CK01.114D.D4 CK01.116A.H9 CK01.116B.F4 CK01.117B.B4 CK01.119C.F8 CK01.124A.G10 CK01.129C.C8 CK01.132D.D4 CK01.133B.H4 Dmel_neb_009860_0939_1273 Dmel_neb_010847_0688_3350 EC34628 EC38672 EC052141 EC053225 EC053634 EC054129 EC054216 EC054668 EC055395 EC055396 EC055397 EC055398 EK004823 EK019340 EK031130 EK046049 EK046245 EK046349 EK048557 EK052313 EK054139 EK056739 EK058163 EK064111 EK065019 EK066444 EK067143 EK070136 EK071442 EK075359 EK075621 EK077656 EK081033 EK085256 EK086459 EK086937 EK091156 EK092154 EK095944 EK098811 EK101246 EK101962 EK105824 EK107018 EK109415 EK123262 EK126558 EK129333 EK135346 EK136056 EK140859 EK146922 EK149252 EK151613 EK152111 EK153961 EK157154 EK160263 EK164540 EK165046 EK166217 EK166839 EK166850 EK170551 EK171243 EK173360 EK176649 EK176741 EK180921 EK181459 EK184909 EK185533 EK186060 EK189333 EK189862 EK194925 EK202021 EK209851 EK213208 EK219027 EK225241 EK226057 EK227933 EK228318 EK233110 EK238961 EK240358 EK244342 EK245446 EK256410 EK257105 EK263143 EK263933 EK264817 EK268353 EK271501 EK274237 EK280605 EK282125 EK287201 EK292319 EK293840 EK304038 EK308226 EP00424 EP00914 EP03058 EP04730 EP05712 EP09917 EP11845 EP12918 EP14150 EP14840 EP15247 EP20061 EP21735 EP22319 ESG014a.E21_F02 ESG0120a.B21_F05 IP15277 IP15477 IP15577 LD06908 LD11526 LD17222 LD20945 RP004038896 RP004040725 RP004049470 RP004065910 RP004101372 RP004128493 RP004133418 RP004174733 RP004177864 RP004178963 RP004198269 RP004199264 RP004199865 RP004206852 RP004221455 RP004227634 RP004234083 RP004242392 RP004265524 RP004329372 RP004358138 RP004365482 RP004417997 RP004418061 RP004420093 RP004426976 RP004435026 RP004467960 RP004473520 RP004477238 RP004478736 RP004535149 RP004536463 RP004539052 RP004559615
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025726 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43841
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: unc-13 l(4)ry16 (Cook, 2005.11.8)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Identification: Cam-binding protein that is expressed in the retina. (Xu et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143692 NM_166793 NM_166794 NM_001258497 NM_001258498 NM_001272146 RefSeq (Proteins) • NP_651949 NP_726614 NP_726615 NP_001245426 NP_001245427 NP_001259075 DDBJ / EMBL / GenBank • AA440630 AA950388 AAF22962 AAF59405 AAF59405.3 AAL39704 AAM11142 AAN06592 AAN06592.1 AAN06593 AAN06593.1 AC010916 AF169141 AF433740 AF433741 AF433742 AF433743 AF433744 AF433745 AF433746 AF433747 AF433748 AF433749 AFH06786 AFH06787 AGB96565 AW942359 AW942917 AY069559 AY094789 CAA76941 CAA76942 CZ489839 CZ489840 Y17921 Y17922 Entrez Gene - A searchable database of RefSeq genes. • 43841 UniProtKB/TrEMBL • H9XVP2 O96959 O96960 Q8IM86 Q8IM87 Q8SX82 Q8T049 Q9U4K9 Q9V483
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • C2 membrane targeting protein (IPR018029) C2 calcium-dependent membrane targeting (IPR000008) Protein kinase C-like, phorbol ester/diacylglycerol binding (IPR002219) C2 calcium/lipid-binding domain, CaLB (IPR008973) Calcium-dependent secretion activator (IPR010439) Munc13 homology 1 (IPR014770) Mammalian uncoordinated homology 13, domain 2 (IPR014772) Mammalian uncoordinated homology 13, subgroup, domain 2 (IPR019558) Uncoordinated protein 13 (Unc-13) (IPR027080) C2 domain (IPR020477)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68665 DroID - A comprehensive database of gene and protein interactions. • FBgn0025726 DRSC - Results from RNAi screens. • FBgn0025726 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025726 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2999-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025726 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43841 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/unc13-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43841 modMine - Data generated by the modENCODE project. • FBgn0025726
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	CG2999 (Verstreken and Bellen, 2000.9.4, Quinones-Coello, 2007, Keleman et al., 2009.8.5, Perkins et al., 2009, Rees et al., 2011) drunc13 (Locke et al., 2000) DUNC-13 (Korhonen and Lindholm, 2004, Aravamudan and Broadie, 2003) Dunc-13 (Aravamudan et al., 1999, Hoopengardner et al., 2003, Kueppers et al., 2003) dUnc-13 (Richmond and Broadie, 2002, Jepson and Reenan, 2009) Dunc13 (Cline, 2003) dUNC-13 (Renden et al., 2001, Montell, 1999, Xu et al., 1998, Huang et al., 2006) dunc-13 (Lloyd et al., 2000) l(4)ry16 (Hirsh, 1991.11.1, ) Munc-13 (Littleton, 2000) Munc-13/UNC-13 (Zhen and Jin, 2004) unc (Savva et al., 2012) UNC-13 (Montell, 1998.8.11) unc-13 (Podemski et al., 2004, Roote, 2006.7.27, Quinones-Coello, 2007, Dietzl et al., 2007, Rees et al., 2011, Mudiganti et al., 2010, Deng et al., 2009, Bhogal et al., 2011, McIntyre et al., 2006, Wasbrough et al., 2010, Jepson et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Graze et al., 2012, Savva et al., 2012, Felix et al., 2012) Unc-13 (Kadener et al., 2009, Savva et al., 2012) UNC-13-B (Montell, 1998.8.11) unnamed (Berg and Spradling, 1991)
Name Synonym	lethal (4) ry16   unc-13
Secondary FlyBase IDs
	FBgn0013637
References ( 65 )
Generate a list of	All references relating to this gene ( 65 )
List References by type	Research paper  ( 30 ) Supplementary material  ( 8 ) Review  ( 5 ) Personal communication to FlyBase  ( 14 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 6 )
	Felix et al., 2012, Genetics 191(3): 989--1002 Age-Specific Variation in Immune Response in Drosophila melanogaster Has a Genetic Basis. [FBrf0218944] Graze et al., 2012, Mol. Biol. Evol. 29(6): 1521--1532 Allelic imbalance in Drosophila hybrid heads: exons, isoforms, and evolution. [FBrf0218297] Savva et al., 2012, Nat. Commun. 3: 790 Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila. [FBrf0218141] Bhogal et al., 2011, Nat. Neurosci. 14(12): 1517--1524 Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein. [FBrf0216747] Jepson et al., 2011, J. Biol. Chem. 286(10): 8325--8337 Engineered Alterations in RNA Editing Modulate Complex Behavior in Drosophila: REGULATORY DIVERSITY OF ADENOSINE DEAMINASE ACTING ON RNA (ADAR) TARGETS. [FBrf0213236] Rees et al., 2011, Mol. Cell. Proteomics 10(6): M110.002386 In Vivo Analysis of Proteomes and Interactomes Using Parallel Affinity Capture (iPAC) Coupled to Mass Spectrometry. [FBrf0213845] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...