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Gene Dmel\pon

General Information
Symbol	Dmel\pon	Species	D. melanogaster
Name	partner of numb	Annotation symbol	CG3346
Feature type	protein_coding_gene	FlyBase ID	FBgn0025739
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	4C10-4C10	Sequence location	X:4,530,363..4,533,145 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene partner of numb is referred to in FlyBase by the symbol Dmel\pon (CG3346, FBgn0025739). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. It is reported to be involved in the biological process: asymmetric neuroblast division; asymmetric protein localization. 21 alleles are reported. The phenotypes of these alleles are annotated with: abdominal 6 lateral transverse muscle 3; abdominal 2 lateral transverse muscle 3; abdominal 4 lateral transverse muscle 3; embryonic/larval pericardial cell; abdominal 5 lateral transverse muscle 3; abdominal 3 lateral transverse muscle 3; abdominal 7 lateral transverse muscle 3; embryonic/larval somatic muscle. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1628732_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of pon. Gene sequence location is X:4530363..4533145.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Transgenic Constructs P{phyl-EGFP-pon.LD} References Georgiou and Baum, 2010, J. Cell Sci. 123(7): 1089--1098
FB2012_01	Controlled Vocabulary Terms neuroblast MP2 basal References Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Sequence features BKN45319 BKN23799 HFA18823
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 4C10-4C10   Limits computationally determined from genome sequence between P{EP}CG2930EP1352 and P{EP}EP425
Experimentally Determined Cytological Location
Cytogenetic map Notes References 4C7-4C8     (Lu, 1998.9.10)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\pon for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) pon-RA FBtr0070681  NM_080333   2589   670
Additional Transcript Data & Comments
Reported size (kB)	2.9 (longest cDNA) (Lu et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein pon-PA   FBpp0070649   76.2   670   6.90     NP_525072   AAF45964
Additional Polypeptide Data & Comments
Reported size (kDa)	672 (aa); 76 (kD predicted) (Lu et al., 1998)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF45964   AF091050 AAC71019   AY075515 AAL68323   BI165039   BI237596   BI371729   BI376085   BI482261   BI482755   BI577908   BI625087   CO291558   CO301170   CO331719   CZ480177   EC074964   EC090529   GH748743   GH749626   GH750367   GH752106   GH753560   GH753576   GH755040   GH756168   GH757473   GH757481   GH758203   GH761181   GH772798   GH775042   GH776151   GH776194   GH779109   GH780298   GH781829   GH783217   GH784854   GH785519   GH786095   GH787008   GH787848   GH788674   GH788843   GH788938   GH788995   GH789084   GH793611   GH794209   GH796171   GH798319   GH802162   GH802246   GH806770   GH807055   GH807935   GH809450   GH812316   GH814106   GH815010   GH815940   GH816423   GH816994   GH818646   GH820820   GH823043   GH823124   GH824992   GH825640   GH826178   GH828134   GH829501   GH831222   GH832810   GH833690   GH834929   GH838148   GH838890   GH840318   GH840797   GH840849   GH842339   GH843123   GH846304   GH848135   GH852777   GH855771   GH860339   GH860797   GH861030   GH861872   GH862596   GH863179   GH864108   GH864392   GH864586   GH865281   GH865895   GH867126   GH867528   GH867596   GH869670   GH871507   GH873646   GH878303   GH884685   GH884837   GH885171   GH886234   GH887776   GH888007   GH888197   GH888326   GH890840   GH891145   GH891212   GH891380   GH892470   GH892990   GH894025   GH898494   GH898929   GH899999   GH900958   GH902203   GH902773   GH904208   GH907918   GH908721   GH912716   GH923183   GH924133   GH928077   GH928135   GH928740   GH928971   GH929407   GH932082   GH933081   GH933562   GH933658   GH933816   GH936427   GH937635   GH939530   GH940722   GH940999
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O96561 Q9W4I7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   myoblast   (Lu et al., 1998) sensory mother cell   (Lu et al., 1998) neuroblast   (Lu et al., 1998)
Additional Descriptive Data
	pon transcript is expressed in neuroblasts, in sensory organ precursor cells, and in muscle progenitor cells in the mesoderm. (Lu et al., 1998)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   neuroblast   (Lu et al., 1998) neuroblast MP2 | basal   • basal cortex (Rath et al., 2002) embryonic stage 10 -- 11   myoblast   (Lu et al., 1998) embryonic stage 13 -- 14   sensory mother cell   (Lu et al., 1998) prepupal stage   external sensory organ precursor cell & imaginal disc   (Lu et al., 1998)
Additional Descriptive Data
	In embryos, pon protein is expressed in neuroblasts, sensory organ precursor cells, and muscle precursor cells. In imaginal discs during puparium formation, pon protein expression is detected in adult sensory organ precursor cells. (Lu et al., 1998)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0025739    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0025739 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0025739 expression level Developmental Stage   Expression Level embryo 00-02hr    1372 embryo 02-04hr    1273 embryo 04-06hr    4708 embryo 06-08hr    7908 embryo 08-10hr    5399 embryo 10-12hr    3056 embryo 12-14hr    1341 embryo 14-16hr    746 embryo 16-18hr    362 embryo 18-20hr    281 embryo 20-22hr    144 embryo 22-24hr    182 larva L1    114 larva L2    114 larva L3 12hr old    137 larva L3 puffstage 1-2    415 larva L3 puffstage 3-6    636 larva L3 puffstage 7-9    728 white prepupae new    689 white prepupae 12hr    962 white prepupae 24hr    929 pupae 2d postWPP    161 pupae 3d postWPP    60 pupae 4d postWPP    86 adult male 01day    70 adult male 05day    101 adult male 30day    105 adult female 01day    285 adult female 05day    454 adult female 30day    599 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1372) embryo 02-04hr  (1273) embryo 04-06hr  (4708) embryo 06-08hr  (7908) embryo 08-10hr  (5399) embryo 10-12hr  (3056) embryo 12-14hr  (1341) embryo 14-16hr  (746) embryo 16-18hr  (362) embryo 18-20hr  (281) embryo 20-22hr  (144) embryo 22-24hr  (182) larva L1  (114) larva L2  (114) larva L3 12hr old  (137) larva L3 puffstage 1-2  (415) larva L3 puffstage 3-6  (636) larva L3 puffstage 7-9  (728) white prepupae new  (689) white prepupae 12hr  (962) white prepupae 24hr  (929) pupae 2d postWPP  (161) pupae 3d postWPP    60 pupae 4d postWPP    86 adult male 01day    70 adult male 05day  101 adult male 30day  105 adult female 01day  (285) adult female 05day  (454) adult female 30day  (599) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1372 embryo 02-04hr    1273 embryo 04-06hr  (4708) embryo 06-08hr  (7908) embryo 08-10hr  (5399) embryo 10-12hr  (3056) embryo 12-14hr    1341 embryo 14-16hr    746 embryo 16-18hr    362 embryo 18-20hr    281 embryo 20-22hr    144 embryo 22-24hr    182 larva L1    114 larva L2    114 larva L3 12hr old    137 larva L3 puffstage 1-2    415 larva L3 puffstage 3-6    636 larva L3 puffstage 7-9    728 white prepupae new    689 white prepupae 12hr    962 white prepupae 24hr    929 pupae 2d postWPP    161 pupae 3d postWPP    60 pupae 4d postWPP    86 adult male 01day    70 adult male 05day    101 adult male 30day    105 adult female 01day    285 adult female 05day    454 adult female 30day    599 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1372 embryo 02-04hr    1273 embryo 04-06hr    4708 embryo 06-08hr    7908 embryo 08-10hr    5399 embryo 10-12hr    3056 embryo 12-14hr    1341 embryo 14-16hr    746 embryo 16-18hr    362 embryo 18-20hr    281 embryo 20-22hr    144 embryo 22-24hr    182 larva L1    114 larva L2    114 larva L3 12hr old    137 larva L3 puffstage 1-2    415 larva L3 puffstage 3-6    636 larva L3 puffstage 7-9    728 white prepupae new    689 white prepupae 12hr    962 white prepupae 24hr    929 pupae 2d postWPP    161 pupae 3d postWPP    60 pupae 4d postWPP    86 adult male 01day    70 adult male 05day    101 adult male 30day    105 adult female 01day    285 adult female 05day    454 adult female 30day    599 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1372 embryo 02-04hr    1273 embryo 04-06hr    4708 embryo 06-08hr    7908 embryo 08-10hr    5399 embryo 10-12hr    3056 embryo 12-14hr    1341 embryo 14-16hr    746 embryo 16-18hr    362 embryo 18-20hr    281 embryo 20-22hr    144 embryo 22-24hr    182 larva L1    114 larva L2    114 larva L3 12hr old    137 larva L3 puffstage 1-2    415 larva L3 puffstage 3-6    636 larva L3 puffstage 7-9    728 white prepupae new    689 white prepupae 12hr    962 white prepupae 24hr    929 pupae 2d postWPP    161 pupae 3d postWPP    60 pupae 4d postWPP    86 adult male 01day    70 adult male 05day    101 adult male 30day    105 adult female 01day    285 adult female 05day    454 adult female 30day    599 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0025739 expression level Developmental Stage   Expression Level embryo 00-02hr    1372 embryo 02-04hr    1273 embryo 04-06hr    4708 embryo 06-08hr    7908 embryo 08-10hr    5399 embryo 10-12hr    3056 embryo 12-14hr    1341 embryo 14-16hr    746 embryo 16-18hr    362 embryo 18-20hr    281 embryo 20-22hr    144 embryo 22-24hr    182 larva L1    114 larva L2    114 larva L3 12hr old    137 larva L3 puffstage 1-2    415 larva L3 puffstage 3-6    636 larva L3 puffstage 7-9    728 white prepupae new    689 white prepupae 12hr    962 white prepupae 24hr    929 pupae 2d postWPP    161 pupae 3d postWPP    60 pupae 4d postWPP    86 adult male 01day    70 adult male 05day    101 adult male 30day    105 adult female 01day    285 adult female 05day    454 adult female 30day    599 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1372) embryo 02-04hr  (1273) embryo 04-06hr  (4708) embryo 06-08hr  (7908) embryo 08-10hr  (5399) embryo 10-12hr  (3056) embryo 12-14hr  (1341) embryo 14-16hr  (746) embryo 16-18hr  (362) embryo 18-20hr  (281) embryo 20-22hr  (144) embryo 22-24hr  (182) larva L1  114 larva L2  114 larva L3 12hr old  137 larva L3 puffstage 1-2  (415) larva L3 puffstage 3-6  (636) larva L3 puffstage 7-9  (728) white prepupae new  (689) white prepupae 12hr  (962) white prepupae 24hr  (929) pupae 2d postWPP  (161) pupae 3d postWPP    60 pupae 4d postWPP    86 adult male 01day    70 adult male 05day  101 adult male 30day  105 adult female 01day  (285) adult female 05day  (454) adult female 30day  (599) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1372 embryo 02-04hr    1273 embryo 04-06hr  (4708) embryo 06-08hr  (7908) embryo 08-10hr  (5399) embryo 10-12hr  (3056) embryo 12-14hr    1341 embryo 14-16hr    746 embryo 16-18hr    362 embryo 18-20hr    281 embryo 20-22hr    144 embryo 22-24hr    182 larva L1    114 larva L2    114 larva L3 12hr old    137 larva L3 puffstage 1-2    415 larva L3 puffstage 3-6    636 larva L3 puffstage 7-9    728 white prepupae new    689 white prepupae 12hr    962 white prepupae 24hr    929 pupae 2d postWPP    161 pupae 3d postWPP    60 pupae 4d postWPP    86 adult male 01day    70 adult male 05day    101 adult male 30day    105 adult female 01day    285 adult female 05day    454 adult female 30day    599 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1372 embryo 02-04hr    1273 embryo 04-06hr    4708 embryo 06-08hr    7908 embryo 08-10hr    5399 embryo 10-12hr    3056 embryo 12-14hr    1341 embryo 14-16hr    746 embryo 16-18hr    362 embryo 18-20hr    281 embryo 20-22hr    144 embryo 22-24hr    182 larva L1    114 larva L2    114 larva L3 12hr old    137 larva L3 puffstage 1-2    415 larva L3 puffstage 3-6    636 larva L3 puffstage 7-9    728 white prepupae new    689 white prepupae 12hr    962 white prepupae 24hr    929 pupae 2d postWPP    161 pupae 3d postWPP    60 pupae 4d postWPP    86 adult male 01day    70 adult male 05day    101 adult male 30day    105 adult female 01day    285 adult female 05day    454 adult female 30day    599 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1372 embryo 02-04hr    1273 embryo 04-06hr    4708 embryo 06-08hr    7908 embryo 08-10hr    5399 embryo 10-12hr    3056 embryo 12-14hr    1341 embryo 14-16hr    746 embryo 16-18hr    362 embryo 18-20hr    281 embryo 20-22hr    144 embryo 22-24hr    182 larva L1    114 larva L2    114 larva L3 12hr old    137 larva L3 puffstage 1-2    415 larva L3 puffstage 3-6    636 larva L3 puffstage 7-9    728 white prepupae new    689 white prepupae 12hr    962 white prepupae 24hr    929 pupae 2d postWPP    161 pupae 3d postWPP    60 pupae 4d postWPP    86 adult male 01day    70 adult male 05day    101 adult male 30day    105 adult female 01day    285 adult female 05day    454 adult female 30day    599 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0025739    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0025739 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0025739 expression level Tissue   Expression Level Larval Central Nervous System    399.925 Larval Midgut    20.1 Larval Hindgut    15.9 Larval Malpighian Tubules    6.7 Larval Fat Body    16 Larval Salivary Gland no informative data Larval Trachea    39.575 Larval Carcass    27.775 Adult Head    8.3 Adult Eye    4.675 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    12.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.9 Adult Malpighian Tubules    4.1 Adult Fat Body    8.2 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    5 Adult Ovary    102.4 Adult Testis    18.5 Adult Male Accessory Gland    7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    399.925 Larval Midgut    20.1 Larval Hindgut    15.9 Larval Malpighian Tubules    6.7 Larval Fat Body    16 Larval Salivary Gland no informative data Larval Trachea    39.575 Larval Carcass    27.775 Adult Head    8.3 Adult Eye    4.675 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    12.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.9 Adult Malpighian Tubules    4.1 Adult Fat Body    8.2 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    5 Adult Ovary    102.4 Adult Testis    18.5 Adult Male Accessory Gland    7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    399.925 Larval Midgut    20.1 Larval Hindgut    15.9 Larval Malpighian Tubules    6.7 Larval Fat Body    16 Larval Salivary Gland no informative data Larval Trachea    39.575 Larval Carcass    27.775 Adult Head    8.3 Adult Eye    4.675 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    12.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.9 Adult Malpighian Tubules    4.1 Adult Fat Body    8.2 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    5 Adult Ovary    102.4 Adult Testis    18.5 Adult Male Accessory Gland    7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    399.925 Larval Midgut    20.1 Larval Hindgut    15.9 Larval Malpighian Tubules    6.7 Larval Fat Body    16 Larval Salivary Gland no informative data Larval Trachea    39.575 Larval Carcass    27.775 Adult Head    8.3 Adult Eye    4.675 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    12.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.9 Adult Malpighian Tubules    4.1 Adult Fat Body    8.2 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    5 Adult Ovary    102.4 Adult Testis    18.5 Adult Male Accessory Gland    7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0025739 expression level Tissue   Expression Level Larval Central Nervous System    399.925 Larval Midgut    20.1 Larval Hindgut    15.9 Larval Malpighian Tubules    6.7 Larval Fat Body    16 Larval Salivary Gland no informative data Larval Trachea    39.575 Larval Carcass    27.775 Adult Head    8.3 Adult Eye    4.675 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    12.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.9 Adult Malpighian Tubules    4.1 Adult Fat Body    8.2 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    5 Adult Ovary    102.4 Adult Testis    18.5 Adult Male Accessory Gland    7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    399.925 Larval Midgut    20.1 Larval Hindgut    15.9 Larval Malpighian Tubules    6.7 Larval Fat Body    16 Larval Salivary Gland no informative data Larval Trachea    39.575 Larval Carcass    27.775 Adult Head    8.3 Adult Eye    4.675 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    12.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.9 Adult Malpighian Tubules    4.1 Adult Fat Body    8.2 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    5 Adult Ovary    102.4 Adult Testis    18.5 Adult Male Accessory Gland    7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    399.925 Larval Midgut    20.1 Larval Hindgut    15.9 Larval Malpighian Tubules    6.7 Larval Fat Body    16 Larval Salivary Gland no informative data Larval Trachea    39.575 Larval Carcass    27.775 Adult Head    8.3 Adult Eye    4.675 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    12.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.9 Adult Malpighian Tubules    4.1 Adult Fat Body    8.2 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    5 Adult Ovary    102.4 Adult Testis    18.5 Adult Male Accessory Gland    7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    399.925 Larval Midgut    20.1 Larval Hindgut    15.9 Larval Malpighian Tubules    6.7 Larval Fat Body    16 Larval Salivary Gland no informative data Larval Trachea    39.575 Larval Carcass    27.775 Adult Head    8.3 Adult Eye    4.675 Adult Brain    4.9 Adult Thoracic-Abdominal Ganglion    12.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.9 Adult Malpighian Tubules    4.1 Adult Fat Body    8.2 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    5 Adult Ovary    102.4 Adult Testis    18.5 Adult Male Accessory Gland    7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    8.3   NA  Eye    4.675   NA  Brain    4.9   399.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    12.7   NA  Crop    no informative data   20.1  Midgut    no informative data   15.9  Hindgut    9.9   6.7  Malpighian Tubules    4.1   16  Fat Body    8.2   no informative data  Salivary Gland    6.2   NA  Heart    3.075   39.575  Trachea    NA   NA  VirginFemale Spermatheca    4.9   NA  InseminatedFemale Spermatheca    5   NA  Ovary    102.4   NA  Testis    18.5   NA  Male Accessory Gland    7   27.775  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025739 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3346-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable pone02353 viable, with Scer\GAL4pnr-MD237 ponGD15568 Sterility Allele fertile pone02353 Other Phenotypes Allele hyperplasia | somatic clone ponunspecified neuroanatomy defective | somatic clone ponunspecified Phenotype manifest in Allele abdominal 2 lateral transverse muscle 3 ponP65 abdominal 3 lateral transverse muscle 3 ponP65 abdominal 4 lateral transverse muscle 3 ponP65 abdominal 5 lateral transverse muscle 3 ponP65 abdominal 6 lateral transverse muscle 3 ponP65 abdominal 7 lateral transverse muscle 3 ponP65 embryonic/larval pericardial cell ponP65 embryonic/larval somatic muscle ponP65 neuroblast | somatic clone ponunspecified
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of pon Class Mutagen Stocks Known lesion pone02353 piggyBac transposase 2 -- ponP26 P-element activity 0 Yes ponP65 P-element activity 0 Yes ponunspecified 0 --
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of pon Class Mutagen Stocks Known lesion ponGD15568 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ponHMS01460 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ponFS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ponKK103607 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ponLD.phyl.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ponLD.Scer\UAS.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ponS611A.LD.Scer\UAS.T:Avic\GFP in vitro construct - amino acid replacement 0 Yes ponS611A.Scer\UAS in vitro construct - amino acid replacement 0 Yes ponS611D.LD.Scer\UAS.T:Avic\GFP in vitro construct - amino acid replacement 0 Yes ponS611D.Scer\UAS in vitro construct - amino acid replacement 0 Yes ponScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes ponScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ponScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ponΔ1.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ponΔ2.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ponΔ3.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ponΔ4.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)bi-D3 (Lu et al., 1998)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD15568} NA P{KK103607} NA P{TRiP.HMS01460} NA P{UAS-pon.GFP.LD.S611A} NA P{UAS-pon.GFP.LD.S611D} NA P{UAS-pon.GFP} NA P{UAS-pon.RFP.LD} NA P{UAS-pon.S611A} NA P{UAS-pon.S611D} NA P{UAS-pon.T:Myc} NA P{UAS-pon.W} NA P{UAS-pon.Δ1} NA P{UAS-pon.Δ2} NA P{UAS-pon.Δ3} NA P{UAS-pon.Δ4} NA characterization construct P{phyl-EGFP-pon.LD} NA P{UAS-pon::raps.C-pon} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}pone02353 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
cell cortex inferred from direct assay (Mayer et al., 2005) cytoplasm inferred from direct assay (Mayer et al., 2005)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
asymmetric neuroblast division traceable author statement (Tree et al., 2002) asymmetric protein localization traceable author statement (Cheah et al., 2000)
Cellular Component
CV term Evidence References
basal cortex non-traceable author statement (Cayouette and Raff, 2002, Schaefer and Knoblich, 2001) basal part of cell traceable author statement (Gonczy, 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions pon allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0025739
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21417 Dere\GG18716 Dgri\GH17884 Dmoj\GI16456 Dper\GL18584 Dpse\GA27120 Dsec\GM12356 Dsim\GD16699 Dvir\GJ15857 Dwil\GK16161 Dyak\GE16355
Curated drosophilid orthologs	Dpse\GA17394
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011801-PA Aedes aegypti (mosquito) AGAP003351-PA Anopheles gambiae (mosquito) CPIJ015024 Culex pipens (mosquito) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233885 FBgn0218163 FBgn0203044 FBgn0188288 FBgn0167293 FBgn0248491 FBgn0156185 FBgn0152362 FBgn0139204 FBgn0125353 FBgn0110925 FBgn0098419 CPIJ015024 AGAP003351 AAEL011801
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	18045 w1118 PBac{RB}pone02353 35046 y1 sc* v1; P{TRiP.HMS01460}attP2
Harvard	- PBac{RB}pone02353
VDRC	v39269 w1118; P{GD15568}v39269/CyO
Genomic Clones ( 2 )
	BACR17H06 BACR38L01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 143 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE65495
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE04841 RE33847 RE58680 RE64015 RE64930 RE71672 RH64936
Other clones	70220 273624 EK180301 EK197634 EK301331 RP003012143 RP003017761 RP003029902 RP003032764 RP003037472 RP003040559 RP003041748 RP003059669 RP003060723 RP003064911 RP003067339 RP003073396 RP003078755 RP003079103 RP003079522 RP003081459 RP003115942 RP003128603 RP003134786 RP003134796 RP003135230 RP003139662 RP003139686 RP003140915 RP003143219 RP003151146 RP003161279 RP003163248 RP003167168 RP003168317 RP003169093 RP003175088 RP003179162 RP003181150 RP003182887 RP003185833 RP003190706 RP003191292 RP003196019 RP003201927 RP003208667 RP003208688 RP003213297 RP003227202 RP003228685 RP003231183 RP003232083 RP003235548 RP003238680 RP003249395 RP003252495 RP003263812 RP003268085 RP003269335 RP003270833 RP003274085 RP003280093 RP003295822 RP003296245 RP003297308 RP003298290 RP003311926 RP003320247 RP003333475 RP003337036 RP003338804 RP003343604 RP003348845 RP003351289 RP003371791 RP003394078 RP003394745 RP003407938 RP003408717 RP003410273 RP003412672 RP003415703 RP003419149 RP003425596 RP003426514 RP003430850 RP003436006 RP003438155 RP003449638 RP003456820 RP003467600 RP003470304 RP003472400 RP003479478 RP003493203 RP003496411 RP003501464 RP003505050 RP003505502 RP003506400 RP003507155 RP003510312 RP003516790 RP003526615 RP003526966 RP003531183 RP003531345 RP003535531 RP003536534 RP003536722 RP003539703 RP003541178 RP003544377 RP003545883 RP003550616 RP003558235 RP003561324 RP003568558 RP003569412 RP003570780 RP003574588 RP003585863 RP003586347 RP003597456 RP003601843 RP003602834 RP003606184 RP003607114 RP003625974 RP003632050 RP003634827 RP003655901 RP003656433 RP003657281 RP003669338
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025739 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31394
Antibody Information
	polyclonal (Lu et al., 1998)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: pon CG3346 (Zhong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	The asymmetric localisation of pon seen during neuroblast division takes place at the protein level and the C-terminal region of the protein is necessary and sufficient for asymmetric localisation. (Lu et al., 1999) Identification: Yeast two-hybrid screen to identify proteins that interact with the numb PTB domain. (Lu et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080333 RefSeq (Proteins) • NP_525072 DDBJ / EMBL / GenBank • AAC71019 AAF45964 AAL68323 AF091050 AY075515 BI482755 CZ480177 Entrez Gene - A searchable database of RefSeq genes. • 31394 UniProtKB/TrEMBL • O96561 Q9W4I7
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0025739 DRSC - Results from RNAi screens. • FBgn0025739 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025739 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3346-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025739 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31394 InParanoid A subset of ortholog calls from InParanoid. • AAEL011801-PA Aedes aegypti (mosquito) AGAP003351-PA Anopheles gambiae (mosquito) CPIJ015024 Culex pipens (mosquito) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/partnernumb.htm modMine - Data generated by the modENCODE project. • FBgn0025739 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233885 FBgn0218163 FBgn0203044 FBgn0188288 FBgn0167293 FBgn0248491 FBgn0156185 FBgn0152362 FBgn0139204 FBgn0125353 FBgn0110925 FBgn0098419 CPIJ015024 AGAP003351 AAEL011801
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG3346 (Keleman et al., 2009.8.5, Ni et al., 2011.7.19) Pon (Justice et al., 2003, Bellaiche et al., 2001, Mummery-Widmer et al., 2009, Rujano et al., 2006, Wang et al., 2006, Karcavich and Doe, 2005, Lee and Lundell, 2007, Nishimura et al., 2007, Lee et al., 2006, Wang et al., 2007, Roegiers et al., 2005, Hutterer et al., 2006, Yamashita et al., 2005, Dawes-Hoang and Wieschaus, 2001, Wang et al., 2005, Gallagher and Knoblich, 2006, Wirtz-Peitz et al., 2008, Perdigoto et al., 2008, Remaud et al., 2008, Spasić et al., 2008, Sousa-Nunes et al., 2009, Gomes et al., 2009, Rath et al., 2002, Wang et al., 2009, Wirtz-Peitz et al., 2008, Nishimura et al., 2008, Januschke and Gonzalez, 2010, Georgiou and Baum, 2010) PON (Lu, 1998.9.10, Slack et al., 2007, Simon et al., 2009, Chang et al., 2010) pon (Emery et al., 2005, Yu et al., 2002, Jafar-Nejad et al., 2005, Akdemir et al., 2007, Chia et al., 2008, Egger et al., 2007, Cohen et al., 2010, Januschke and Gonzalez, 2010, Chang et al., 2010, Nishimura et al., 2008)
Name Synonym	Partner of Numb (Lu, 1998.9.10, Wang et al., 2006, Karcavich and Doe, 2005, Wang et al., 2007, Hutterer et al., 2006, Lin, 2008, Chia et al., 2008, Gomes et al., 2009) partner of numb (Yu et al., 2002) Partner of numb (Perdigoto et al., 2008) Partner Of Numb (Simon et al., 2009)
Secondary FlyBase IDs
References ( 116 )
Generate a list of	All references relating to this gene ( 116 )
List References by type	Research paper  ( 67 ) Supplementary material  ( 3 ) Review  ( 29 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 5 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 6 )
	Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Cytokinesis remnants define first neuronal asymmetry in vivo. [FBrf0216761] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Chang et al., 2010, Dev. Cell 19(5): 778--785 Interplay between the Transcription Factor Zif and aPKC Regulates Neuroblast Polarity and Self-Renewal. [FBrf0212286] Cohen et al., 2010, Dev. Cell 19(1): 78--89 Dynamic Filopodia Transmit Intermittent Delta-Notch Signaling to Drive Pattern Refinement during Lateral Inhibition. [FBrf0211296] Georgiou and Baum, 2010, J. Cell Sci. 123(7): 1089--1098 Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions. [FBrf0214990] Januschke and Gonzalez, 2010, J. Cell Biol. 188(5): 693--706 The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts. [FBrf0210175] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...