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Gene Dmel\homer

General Information
Symbol	Dmel\homer	Species	D. melanogaster
Name	homer	Annotation symbol	CG11324
Feature type	protein_coding_gene	FlyBase ID	FBgn0025777
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	Dhomer
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	27A1-27A1	Sequence location	2L:6,719,394..6,723,359 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene homer is referred to in FlyBase by the symbol Dmel\homer (CG11324, FBgn0025777). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: adult behavior; response to ethanol; regulation of locomotion; positive regulation of circadian sleep/wake cycle, sleep; behavioral response to ethanol. 21 alleles are reported. The phenotype of these alleles is annotated with: tarsal segment. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: EVH1; Pleckstrin homology-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1634147_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of homer. Gene sequence location is 2L:6719394..6723359.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 27A1-27A1   Limits computationally determined from genome sequence between P{EP}Sec61αEP2180 and P{lacW}Ate1k10809
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\homer for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Gene model reviewed during 5.44 Gene model reviewed during 5.46 gene_with_stop_codon_read_through ; SO:0000697 Stop-codon suppression (UGA) postulated; FBrf0216885.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) homer-RA FBtr0079306  NM_058048   1921   394 homer-RB FBtr0079307  NM_164706   2388   397 homer-RD FBtr0329892  NM_001273221   2923   394 homer-RE FBtr0329893  NM_001042876   1921   531 homer-RF FBtr0332330  NM_001273223   1930   397 homer-RG FBtr0333346  NM_001273222   2397   400
Additional Transcript Data & Comments
Reported size (kB)	1.9 (longest cDNA) (Xiao et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein homer-PA   FBpp0078936   42.7   394   7.58     NP_477396   AAF52428 homer-PB   FBpp0078937   43.0   397   7.18     NP_723207   AAF52429 homer-PD   FBpp0302926   42.7   394   7.58     NP_001260150   AGB92686 homer-PE   FBpp0302927   57.3   531   9.02     NP_001036341   ABI31295 homer-PF   FBpp0304608   43.0   397   7.58     NP_001260152   AGB92688 homer-PG   FBpp0305538   43.4   400   7.58     NP_001260151   AGB92687
Additional Polypeptide Data & Comments
Reported size (kDa)	394 (aa) (Xiao et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • EVH1 (IPR000697) Pleckstrin homology-like domain (IPR011993)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201147   AA202832   AA246370   AA391781   AA441413   AA539645   AA949641   AE014134 AAF52428   AE014134 AAF52429   AE014134 ABI31295   AC003052   AC092397   AF093266 AAC71030   AE014134 AGB92686   AE014134 AGB92687   AE014134 AGB92688   AI532428   AW941536   BF485569   BF493551   BF500227   BG635439   BI173911   BI237536   BI243310   BI484113   BI485338   BI566577   BI567762   BI568627   BI573291   BI573855   BI574394   BI575140   BI576172   BI583570   BI583858   BI584945   BI588194   BI589291   BI605377   BI621852   BI626817   BI626965   BI627143   BI627701   BI629295   BI634550   BP542613   BT004910 AAO49163   BT100111   BT125932   CO154977   CO189810   CO264264   CO264863   CO266677   CO268887   CO270529   CO275853   CO278330   CO281979   CO286463   CO294970   CO296622   CO296847   CO297507   CO298803   CO299507   CO306546   CO308783   CO311230   CO313642   CO313678   CO317229   CO324053   CO325622   CO327551   CO331091   CO340789   CO342737   CZ476769   EC057270   EC058838   EC071116   EC071450   EC073070   EC075524   EC076657   EC080819   EC084957   EC087510   EC088144   EC089159   EC198445   EC202192   EC206194   EC208387   EC209814   EC209992   EC211216   EC212282   EC216957   EC223680   EC224910   EC229164   EC236043   EC240829   EC247663   EC250997   EC254665   EC254871   EC264695   GH942741   GH944344   GH944721   GH950673   GH953501   GH961148   GH966642   GH971710   GH974684   GH975365   GH977913   GH978449
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O96607 Q9VM94 Q0E8S7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 12 -- 17   presumptive embryonic/larval central nervous system   (Diagana et al., 2002) presumptive embryonic/larval peripheral nervous system   (Diagana et al., 2002) scolopidial neuron   (Diagana et al., 2002) bipolar dendrite neuron   (Diagana et al., 2002) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) embryonic stage 16 -- 17   embryonic/larval central nervous system   (Diagana et al., 2002)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12 -- 17   scolopidial neuron   • neuronal cell body (Diagana et al., 2002) sensory neuron   • neuronal cell body (Diagana et al., 2002) embryonic stage 16 -- 17   neuropil of ventral nerve cord   (Diagana et al., 2002) neuron of ventral nerve cord   • endoplasmic reticulum of neuronal cell body (Diagana et al., 2002) larval stage   embryonic/larval central nervous system   (Diagana et al., 2002) pupal stage -- adult stage   adult central nervous system   • endoplasmic reticulum of neuronal cell body (Diagana et al., 2002) lamina   • endoplasmic reticulum of neuronal cell body (Diagana et al., 2002) medulla   • endoplasmic reticulum of neuronal cell body (Diagana et al., 2002) adult stage   adult brain | restricted   (Urizar et al., 2007) ellipsoid body   (Urizar et al., 2007) fan-shaped body   (Urizar et al., 2007) adult central complex   (Urizar et al., 2007) adult antennal lobe   (Urizar et al., 2007) optic lobe | restricted   (Urizar et al., 2007) protocerebral bridge   (Urizar et al., 2007) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Diagana et al., 2002)
Additional Descriptive Data
	homer expression in the dorsal neuropil of the embryonic ventral nerve cord overlaps that of synaptotagmin, suggesting synaptic localization. (Diagana et al., 2002)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
dendrite inferred from direct assay (Rolls et al., 2007, Diagana et al., 2002) endoplasmic reticulum inferred from direct assay (Diagana et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    44.325 Larval Midgut    12.1 Larval Hindgut    24.3 Larval Malpighian Tubules    35.2 Larval Fat Body    35.7 Larval Salivary Gland    21.3 Larval Trachea    20.325 Larval Carcass    24.875 Adult Head    63.2 Adult Eye    113.375 Adult Brain    54 Adult Thoracic-Abdominal Ganglion    45.3 Adult Crop    48.6 Adult Midgut    28.7 Adult Hindgut    32.5 Adult Malpighian Tubules    22.3 Adult Fat Body    12.1 Adult Salivary Gland    18.1 Adult Heart    13.55 Adult VirginFemale Spermatheca    9.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    111 Adult Testis    143.2 Adult Male Accessory Gland    23.7 Adult Carcass    24.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    44.325 Larval Midgut    12.1 Larval Hindgut    24.3 Larval Malpighian Tubules    35.2 Larval Fat Body    35.7 Larval Salivary Gland    21.3 Larval Trachea    20.325 Larval Carcass    24.875 Adult Head    63.2 Adult Eye    113.375 Adult Brain    54 Adult Thoracic-Abdominal Ganglion    45.3 Adult Crop    48.6 Adult Midgut    28.7 Adult Hindgut    32.5 Adult Malpighian Tubules    22.3 Adult Fat Body    12.1 Adult Salivary Gland    18.1 Adult Heart    13.55 Adult VirginFemale Spermatheca    9.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    111 Adult Testis    143.2 Adult Male Accessory Gland    23.7 Adult Carcass    24.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    44.325 Larval Midgut    12.1 Larval Hindgut    24.3 Larval Malpighian Tubules    35.2 Larval Fat Body    35.7 Larval Salivary Gland    21.3 Larval Trachea    20.325 Larval Carcass    24.875 Adult Head    63.2 Adult Eye    113.375 Adult Brain    54 Adult Thoracic-Abdominal Ganglion    45.3 Adult Crop    48.6 Adult Midgut    28.7 Adult Hindgut    32.5 Adult Malpighian Tubules    22.3 Adult Fat Body    12.1 Adult Salivary Gland    18.1 Adult Heart    13.55 Adult VirginFemale Spermatheca    9.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    111 Adult Testis    143.2 Adult Male Accessory Gland    23.7 Adult Carcass    24.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    44.325 Larval Midgut    12.1 Larval Hindgut    24.3 Larval Malpighian Tubules    35.2 Larval Fat Body    35.7 Larval Salivary Gland    21.3 Larval Trachea    20.325 Larval Carcass    24.875 Adult Head    63.2 Adult Eye    113.375 Adult Brain    54 Adult Thoracic-Abdominal Ganglion    45.3 Adult Crop    48.6 Adult Midgut    28.7 Adult Hindgut    32.5 Adult Malpighian Tubules    22.3 Adult Fat Body    12.1 Adult Salivary Gland    18.1 Adult Heart    13.55 Adult VirginFemale Spermatheca    9.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    111 Adult Testis    143.2 Adult Male Accessory Gland    23.7 Adult Carcass    24.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    44.325 Larval Midgut    12.1 Larval Hindgut    24.3 Larval Malpighian Tubules    35.2 Larval Fat Body    35.7 Larval Salivary Gland    21.3 Larval Trachea    20.325 Larval Carcass    24.875 Adult Head    63.2 Adult Eye    113.375 Adult Brain    54 Adult Thoracic-Abdominal Ganglion    45.3 Adult Crop    48.6 Adult Midgut    28.7 Adult Hindgut    32.5 Adult Malpighian Tubules    22.3 Adult Fat Body    12.1 Adult Salivary Gland    18.1 Adult Heart    13.55 Adult VirginFemale Spermatheca    9.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    111 Adult Testis    143.2 Adult Male Accessory Gland    23.7 Adult Carcass    24.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    44.325 Larval Midgut    12.1 Larval Hindgut    24.3 Larval Malpighian Tubules    35.2 Larval Fat Body    35.7 Larval Salivary Gland    21.3 Larval Trachea    20.325 Larval Carcass    24.875 Adult Head    63.2 Adult Eye    113.375 Adult Brain    54 Adult Thoracic-Abdominal Ganglion    45.3 Adult Crop    48.6 Adult Midgut    28.7 Adult Hindgut    32.5 Adult Malpighian Tubules    22.3 Adult Fat Body    12.1 Adult Salivary Gland    18.1 Adult Heart    13.55 Adult VirginFemale Spermatheca    9.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    111 Adult Testis    143.2 Adult Male Accessory Gland    23.7 Adult Carcass    24.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    44.325 Larval Midgut    12.1 Larval Hindgut    24.3 Larval Malpighian Tubules    35.2 Larval Fat Body    35.7 Larval Salivary Gland    21.3 Larval Trachea    20.325 Larval Carcass    24.875 Adult Head    63.2 Adult Eye    113.375 Adult Brain    54 Adult Thoracic-Abdominal Ganglion    45.3 Adult Crop    48.6 Adult Midgut    28.7 Adult Hindgut    32.5 Adult Malpighian Tubules    22.3 Adult Fat Body    12.1 Adult Salivary Gland    18.1 Adult Heart    13.55 Adult VirginFemale Spermatheca    9.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    111 Adult Testis    143.2 Adult Male Accessory Gland    23.7 Adult Carcass    24.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    44.325 Larval Midgut    12.1 Larval Hindgut    24.3 Larval Malpighian Tubules    35.2 Larval Fat Body    35.7 Larval Salivary Gland    21.3 Larval Trachea    20.325 Larval Carcass    24.875 Adult Head    63.2 Adult Eye    113.375 Adult Brain    54 Adult Thoracic-Abdominal Ganglion    45.3 Adult Crop    48.6 Adult Midgut    28.7 Adult Hindgut    32.5 Adult Malpighian Tubules    22.3 Adult Fat Body    12.1 Adult Salivary Gland    18.1 Adult Heart    13.55 Adult VirginFemale Spermatheca    9.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    111 Adult Testis    143.2 Adult Male Accessory Gland    23.7 Adult Carcass    24.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    63.2   NA  Eye    113.375   NA  Brain    54   44.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    45.3   NA  Crop    48.6   no informative data  Midgut    28.7   24.3  Hindgut    32.5   35.2  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    13.55   20.325  Trachea    NA   NA  VirginFemale Spermatheca    9.4   NA  InseminatedFemale Spermatheca    7.6   NA  Ovary    111   NA  Testis    143.2   NA  Male Accessory Gland    23.7   24.875  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    56 central nervous system, pupae P8    67 head, virgin 1-day female    59 head, virgin 4-day female    41 head, virgin 20-day female    22 head, mated 1-day female    47 head, mated 4-day female    25 head, mated 20-day female    22 head, mated 1-day male    75 head, mated 4-day male    42 head, mated 20-day male    46 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    17 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    33 carcass, larvae L3 wandering    29 carcass, 1-day adult    11 carcass, 4-day adult    13 carcass, 20-day adult    14 ovary, virgin 4-day female    94 ovary, mated 4-day female    82 testis, mated 4-day male    88 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (59) central nervous system, larvae L3  (56) central nervous system, pupae P8  (67) head, virgin 1-day female  (59) head, virgin 4-day female  (41) head, virgin 20-day female    22 head, mated 1-day female  (47) head, mated 4-day female    25 head, mated 20-day female    22 head, mated 1-day male  (75) head, mated 4-day male  (42) head, mated 20-day male  (46) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    17 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8  (33) carcass, larvae L3 wandering  (29) carcass, 1-day adult    11 carcass, 4-day adult    13 carcass, 20-day adult    14 ovary, virgin 4-day female  (94) ovary, mated 4-day female  (82) testis, mated 4-day male  (88) accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    56 central nervous system, pupae P8    67 head, virgin 1-day female    59 head, virgin 4-day female    41 head, virgin 20-day female    22 head, mated 1-day female    47 head, mated 4-day female    25 head, mated 20-day female    22 head, mated 1-day male    75 head, mated 4-day male    42 head, mated 20-day male    46 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    17 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    33 carcass, larvae L3 wandering    29 carcass, 1-day adult    11 carcass, 4-day adult    13 carcass, 20-day adult    14 ovary, virgin 4-day female    94 ovary, mated 4-day female    82 testis, mated 4-day male    88 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    56 central nervous system, pupae P8    67 head, virgin 1-day female    59 head, virgin 4-day female    41 head, virgin 20-day female    22 head, mated 1-day female    47 head, mated 4-day female    25 head, mated 20-day female    22 head, mated 1-day male    75 head, mated 4-day male    42 head, mated 20-day male    46 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    17 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    33 carcass, larvae L3 wandering    29 carcass, 1-day adult    11 carcass, 4-day adult    13 carcass, 20-day adult    14 ovary, virgin 4-day female    94 ovary, mated 4-day female    82 testis, mated 4-day male    88 accessory gland, mated 4-day male    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    56 central nervous system, pupae P8    67 head, virgin 1-day female    59 head, virgin 4-day female    41 head, virgin 20-day female    22 head, mated 1-day female    47 head, mated 4-day female    25 head, mated 20-day female    22 head, mated 1-day male    75 head, mated 4-day male    42 head, mated 20-day male    46 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    17 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    33 carcass, larvae L3 wandering    29 carcass, 1-day adult    11 carcass, 4-day adult    13 carcass, 20-day adult    14 ovary, virgin 4-day female    94 ovary, mated 4-day female    82 testis, mated 4-day male    88 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (59) central nervous system, larvae L3  (56) central nervous system, pupae P8  (67) head, virgin 1-day female  (59) head, virgin 4-day female  (41) head, virgin 20-day female    22 head, mated 1-day female  (47) head, mated 4-day female    25 head, mated 20-day female    22 head, mated 1-day male  (75) head, mated 4-day male  (42) head, mated 20-day male  (46) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    17 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8  (33) carcass, larvae L3 wandering  29 carcass, 1-day adult    11 carcass, 4-day adult    13 carcass, 20-day adult    14 ovary, virgin 4-day female  (94) ovary, mated 4-day female  (82) testis, mated 4-day male  (88) accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    56 central nervous system, pupae P8    67 head, virgin 1-day female    59 head, virgin 4-day female    41 head, virgin 20-day female    22 head, mated 1-day female    47 head, mated 4-day female    25 head, mated 20-day female    22 head, mated 1-day male    75 head, mated 4-day male    42 head, mated 20-day male    46 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    17 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    33 carcass, larvae L3 wandering    29 carcass, 1-day adult    11 carcass, 4-day adult    13 carcass, 20-day adult    14 ovary, virgin 4-day female    94 ovary, mated 4-day female    82 testis, mated 4-day male    88 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    56 central nervous system, pupae P8    67 head, virgin 1-day female    59 head, virgin 4-day female    41 head, virgin 20-day female    22 head, mated 1-day female    47 head, mated 4-day female    25 head, mated 20-day female    22 head, mated 1-day male    75 head, mated 4-day male    42 head, mated 20-day male    46 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    17 fat body, larvae L3 wandering    6 fat body, white prepupae    20 fat body, pupae P8    33 carcass, larvae L3 wandering    29 carcass, 1-day adult    11 carcass, 4-day adult    13 carcass, 20-day adult    14 ovary, virgin 4-day female    94 ovary, mated 4-day female    82 testis, mated 4-day male    88 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    54 embryo 04-06hr    46 embryo 06-08hr    38 embryo 08-10hr    38 embryo 10-12hr    38 embryo 12-14hr    28 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    18 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    25 white prepupae 24hr    31 pupae 2d postWPP    27 pupae 3d postWPP    20 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    24 adult male 30day    22 adult female 01day    23 adult female 05day    35 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr  (54) embryo 04-06hr  (46) embryo 06-08hr  (38) embryo 08-10hr  (38) embryo 10-12hr  (38) embryo 12-14hr  (28) embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    18 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    25 white prepupae 24hr  (31) pupae 2d postWPP  (27) pupae 3d postWPP    20 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    24 adult male 30day    22 adult female 01day    23 adult female 05day  (35) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    54 embryo 04-06hr    46 embryo 06-08hr    38 embryo 08-10hr    38 embryo 10-12hr    38 embryo 12-14hr    28 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    18 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    25 white prepupae 24hr    31 pupae 2d postWPP    27 pupae 3d postWPP    20 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    24 adult male 30day    22 adult female 01day    23 adult female 05day    35 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    54 embryo 04-06hr    46 embryo 06-08hr    38 embryo 08-10hr    38 embryo 10-12hr    38 embryo 12-14hr    28 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    18 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    25 white prepupae 24hr    31 pupae 2d postWPP    27 pupae 3d postWPP    20 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    24 adult male 30day    22 adult female 01day    23 adult female 05day    35 adult female 30day    35 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    54 embryo 04-06hr    46 embryo 06-08hr    38 embryo 08-10hr    38 embryo 10-12hr    38 embryo 12-14hr    28 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    18 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    25 white prepupae 24hr    31 pupae 2d postWPP    27 pupae 3d postWPP    20 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    24 adult male 30day    22 adult female 01day    23 adult female 05day    35 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr  (54) embryo 04-06hr  (46) embryo 06-08hr  (38) embryo 08-10hr  (38) embryo 10-12hr  (38) embryo 12-14hr  28 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    18 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    25 white prepupae 24hr  31 pupae 2d postWPP  27 pupae 3d postWPP    20 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    24 adult male 30day    22 adult female 01day    23 adult female 05day  (35) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    54 embryo 04-06hr    46 embryo 06-08hr    38 embryo 08-10hr    38 embryo 10-12hr    38 embryo 12-14hr    28 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    18 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    25 white prepupae 24hr    31 pupae 2d postWPP    27 pupae 3d postWPP    20 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    24 adult male 30day    22 adult female 01day    23 adult female 05day    35 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    54 embryo 04-06hr    46 embryo 06-08hr    38 embryo 08-10hr    38 embryo 10-12hr    38 embryo 12-14hr    28 embryo 14-16hr    22 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    17 embryo 22-24hr    18 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    18 white prepupae new    19 white prepupae 12hr    25 white prepupae 24hr    31 pupae 2d postWPP    27 pupae 3d postWPP    20 pupae 4d postWPP    18 adult male 01day    22 adult male 05day    24 adult male 30day    22 adult female 01day    23 adult female 05day    35 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    33 embryonic 1182-4H    36 embryonic GM2    25 embryonic Kc167    33 embryonic S1    31 embryonic S3    33 leg disc CME L1    31 wing disc CME-W2    19 wing disc ML-DmD8    32 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    33 wing disc ML-DmD32    40 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    31 ovary fGS/OSS    21 ovary OSC    19 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (35) Schneider line 2 Sg4  (33) embryonic 1182-4H  (36) embryonic GM2    25 embryonic Kc167  (33) embryonic S1  (31) embryonic S3  (33) leg disc CME L1  (31) wing disc CME-W2    19 wing disc ML-DmD8  (32) wing disc ML-DmD9  (35) wing disc ML-DmD16-c3  (59) wing disc ML-DmD21  (33) wing disc ML-DmD32  (40) haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11  (28) antennal disc ML-DmD20-c5  (33) mixed discs ML-DmD4-c1  (40) CNS ML-DmBG1-c1  26 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2  (31) ovary fGS/OSS    21 ovary OSC    19 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    33 embryonic 1182-4H    36 embryonic GM2    25 embryonic Kc167    33 embryonic S1    31 embryonic S3    33 leg disc CME L1    31 wing disc CME-W2    19 wing disc ML-DmD8    32 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    33 wing disc ML-DmD32    40 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    31 ovary fGS/OSS    21 ovary OSC    19 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    33 embryonic 1182-4H    36 embryonic GM2    25 embryonic Kc167    33 embryonic S1    31 embryonic S3    33 leg disc CME L1    31 wing disc CME-W2    19 wing disc ML-DmD8    32 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    33 wing disc ML-DmD32    40 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    31 ovary fGS/OSS    21 ovary OSC    19 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    33 embryonic 1182-4H    36 embryonic GM2    25 embryonic Kc167    33 embryonic S1    31 embryonic S3    33 leg disc CME L1    31 wing disc CME-W2    19 wing disc ML-DmD8    32 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    33 wing disc ML-DmD32    40 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    31 ovary fGS/OSS    21 ovary OSC    19 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (35) Schneider line 2 Sg4  (33) embryonic 1182-4H  (36) embryonic GM2    25 embryonic Kc167  (33) embryonic S1  31 embryonic S3  (33) leg disc CME L1  31 wing disc CME-W2    19 wing disc ML-DmD8  32 wing disc ML-DmD9  (35) wing disc ML-DmD16-c3  (59) wing disc ML-DmD21  (33) wing disc ML-DmD32  (40) haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11  28 antennal disc ML-DmD20-c5  (33) mixed discs ML-DmD4-c1  (40) CNS ML-DmBG1-c1  26 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2  31 ovary fGS/OSS    21 ovary OSC    19 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    33 embryonic 1182-4H    36 embryonic GM2    25 embryonic Kc167    33 embryonic S1    31 embryonic S3    33 leg disc CME L1    31 wing disc CME-W2    19 wing disc ML-DmD8    32 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    33 wing disc ML-DmD32    40 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    31 ovary fGS/OSS    21 ovary OSC    19 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    33 embryonic 1182-4H    36 embryonic GM2    25 embryonic Kc167    33 embryonic S1    31 embryonic S3    33 leg disc CME L1    31 wing disc CME-W2    19 wing disc ML-DmD8    32 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    33 wing disc ML-DmD32    40 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    26 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    31 ovary fGS/OSS    21 ovary OSC    19 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    24 heat shock, 4-day adult    29 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    61 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    55 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    58 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    55 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (39) cold shock, 4-day adult    24 heat shock, 4-day adult  (29) Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult  (30) Cadmium 100 mM 48 hrs, 4-day adult  (61) Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult  (48) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult  (28) Ethanol 2.5% 3 hrs, larvae L3  (55) Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (58) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (55) Paraquat 10 mM 48 hrs, 4-day adult  (40) Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    24 heat shock, 4-day adult    29 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    61 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    55 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    58 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    55 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    24 heat shock, 4-day adult    29 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    61 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    55 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    58 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    55 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    24 heat shock, 4-day adult    29 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    61 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    55 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    58 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    55 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (39) cold shock, 4-day adult    24 heat shock, 4-day adult  29 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult  30 Cadmium 100 mM 48 hrs, 4-day adult  (61) Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult  (48) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult  28 Ethanol 2.5% 3 hrs, larvae L3  (55) Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (58) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (55) Paraquat 10 mM 48 hrs, 4-day adult  (40) Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    24 heat shock, 4-day adult    29 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    61 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    55 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    58 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    55 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    24 heat shock, 4-day adult    29 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    61 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    55 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    58 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    55 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD03829 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025777 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11324-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for homer Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL429BD homerGS2048 lethal, with Scer\GAL4c355 homerGS2048 lethal, with Scer\GAL4hs.2sev homerGS2048 partially lethal - majority die, with Scer\GAL4dpp.blk1 homerGS2048 viable homerCB02121 homerR102 viable, with Scer\GAL4pnr-MD237 homerGD7272 Sterility Allele fertile homerR102 Other Phenotypes Allele chemical sensitive homerR102 courtship behavior defective | male | recessive homerR102 hyperactive | recessive homerR102 sleep defective homerR102 sleep defective (with Df(2L)ED7007) homerR102 smell perception defective | recessive homerR102 stress response defective homerR102 visible, with Scer\GAL4dpp.blk1 homerGS2048 Phenotype manifest in Allele tarsal segment, with Scer\GAL4dpp.blk1 homerGS2048
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of homer Class Mutagen Stocks Known lesion homerR102 amorphic allele - genetic evidence, loss of function allele Delta2-3 1 Yes homerd09492 P-element activity 1 -- homerEP2141 1 -- homerNP0321 1 -- homerNP6206 1 -- homer35 Delta2-3 0 -- homer77 Delta2-3 0 -- homerCB02121 P-element activity 0 Yes homerGS2048 Delta2-3 0 Yes homerLL17 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of homer Class Mutagen Stocks Known lesion homerGD7272 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes homerHMS02301 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes homerJF02584 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes homerKK107359 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes homerdsRNA.cRa in vitro construct - RNAi 0 Yes homerEVH-1.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 -- homerEVH-2.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 -- homerNIG.11324R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes homerScer\UAS.T:Hsap\MYC,T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes homerScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes homerΔC.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)ED7007 (Naidoo et al., 2012) Df(2L)Exel7027 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7272} NA P{KK107359} NA P{NIG.11324R} NA P{TRiP.HMS02301} NA P{TRiP.JF02584} NA P{UAS-homer.EVH-1.Myc} NA P{UAS-homer.EVH-2.Myc} NA P{UAS-homer.Myc} NA P{UAS-homer.myc-GFP} NA P{UAS-homer.ΔC.Myc} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}homerEP2141 NA P{GSV1}homerGS2048 NA P{XP}homerd09492 NA insertion of enhancer trap P{lacW}homer35 No P{lacW}homer77 No P{lacW}l(2)SH2031SH2031 No insertion of enhancer trap binary system P{GawB}homerNP0321 No P{GawB}homerNP6206 No miscellaneous insertions P{PTT-GB}homerCB02121 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Prosap (Diagana et al., 2002)
Biological Process
CV term Evidence References
adult behavior inferred from mutant phenotype (Diagana et al., 2002) behavioral response to ethanol inferred from mutant phenotype (Urizar et al., 2007) positive regulation of circadian sleep/wake cycle, sleep inferred from mutant phenotype (Naidoo et al., 2012) regulation of locomotion inferred from mutant phenotype (Diagana et al., 2002) response to ethanol inferred from direct assay (Urizar et al., 2007)
Cellular Component
CV term Evidence References
dendrite inferred from direct assay (Rolls et al., 2007, Diagana et al., 2002) endoplasmic reticulum inferred from direct assay (Diagana et al., 2002)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis, 2011.11.18) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
homer - CAP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG10175 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG14356 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG14879 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG15043 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG15236 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG15345 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG30195 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG30287 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG31235 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG33937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG4199 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG4617 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG7429 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - CG8671 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - Cdc27 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - Clp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - GABPI anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - LBR anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - Mp20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - P58IPK anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - Ppt2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - Pu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - Rab9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - RasGAP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - Rrp45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - Tip60 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - Ts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - U2A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - capu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - eya anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - fbl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - kuk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - l(2)37Bb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - l(2)k05819 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - lkb1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - pirk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - scat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - sprt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - ste24a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) homer - tyf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions homer allele Gene References homerLL17 bif (Babu et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60097 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025777 DroID - A comprehensive database of gene and protein interactions. • FBgn0025777 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33944
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6G1N28 Dipteran inclusive ortholog search EOG6KD6VK Insect inclusive ortholog search EOG62RC3V Arthropod inclusive ortholog search EOG6SJ3WC Metazoa inclusive ortholog search EOG635818
Orthologs in Drosophila Species (EOG6G1N28)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\homer     Drosophila sechellia   Dsec\GM13902 Y   Drosophila erecta   Dere\GG23589 Y   Drosophila yakuba   Dyak\GE18410 Y   Drosophila ananassae   Dana\GF14950 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10919 Y   Drosophila persimilis   Dper\GL25967 Y   Drosophila willistoni   Dwil\GK24217 Y   Drosophila virilis   Dvir\GJ15454 Y   Drosophila mojavensis   Dmoj\GI17542 Y   Drosophila grimshawi   Dgri\GH11023 Y
Orthologs in non-Drosophila Dipterans (EOG6KD6VK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011093   Anopheles gambiae Malaria mosquito  Agam\AGAP010076   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009183
Orthologs in non-Dipteran Insects (EOG62RC3V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43427   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007964   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21173   Atta cephalotes Leafcutter ant  Acep\ACEP17503   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13861   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12912   Linepithema humile Argentine ant  Lhum\LH12404   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15778   Solenopsis invicta Red fire ant  Sinv\SINV25631   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002138   Bombyx mori Silkmoth  Bmor\BGIBMGA013976   Bombyx mori Silkmoth  Bmor\BGIBMGA013977   Pediculus humanus Human body louse  Phum\PHUM370830   Tribolium castaneum Red flour beetle  Tcas\TC015941
Orthologs in non-Insect Arthropods (EOG6SJ3WC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Arhgap8   Ixodes scapularis Deer tick  Isca\ISCW001721
Orthologs in non-Arthropod Metazoa (EOG635818)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F36G3.1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015819gn   Danio rerio Zebrafish  Drer\homer1   Danio rerio Zebrafish  Drer\ENSDARG00000073803   Danio rerio Zebrafish  Drer\ENSDARG00000010789   Danio rerio Zebrafish  Drer\homer1   Xenopus tropicalis Western clawed frog  Xtro\homer3   Xenopus tropicalis Western clawed frog  Xtro\homer1   Xenopus tropicalis Western clawed frog  Xtro\homer2   Gallus gallus Domestic chicken  Ggal\HOMER3   Gallus gallus Domestic chicken  Ggal\HOMER1   Gallus gallus Domestic chicken  Ggal\HOMER2   Mus musculus House mouse  Mmus\Homer1   Mus musculus House mouse  Mmus\Homer3   Mus musculus House mouse  Mmus\Homer2   Rattus norvegicus Norway rat  Rnor\Homer2   Rattus norvegicus Norway rat  Rnor\Homer3   Homo sapiens Human  Hsap\ENSG00000051128   Homo sapiens Human  Hsap\HOMER1
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000051128     Hsap\HOMER1
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM13902 Drosophila erecta Dere\GG23589 Drosophila yakuba Dyak\GE18410 Drosophila ananassae Dana\GF14950 Drosophila pseudoobscura pseudoobscura Dpse\GA10919 Drosophila persimilis Dper\GL25967 Drosophila willistoni Dwil\GK24217 Drosophila virilis Dvir\GJ15454 Drosophila mojavensis Dmoj\GI17542 Drosophila grimshawi Dgri\GH11023
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	9564 homerR102 17027 w1118; P{EP}homerEP2141 41908 y1 sc* v1; P{TRiP.HMS02301}attP2 27271 y1 v1; P{TRiP.JF02584}attP2/TM3, Sb1
Harvard	- P{XP}homerd09492
Kyoto	105147 y* w*; P{GawB}homerNP6206 / CyO, P{UAS-lacZ.UW14}UW14 112134 y* w*; P{GawB}homerNP0321 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v100271 P{KK107359}VIE-260B v18061 w1118; P{GD7272}v18061
Genomic Clones ( 1 )
	BACR22N03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 83 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT09976 LD02487 LD03829
Other clones	DPiM_LD03829
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01842 AT14990 AT19607 LD03156 LD05241 LD11505 LD16336 LD17922 LD29608 RE17053 RE33769 RE40902 RE67148 RE68648 RH22219 RH22567 RH23405 RH24291 RH28414 RH29314 RH31684 RH32679 RH36260 RH38339 RH38730 RH40258 RH53273 RH58139 RH67873 RH68133 RH68366 RH69077 RH70967 SD03947 SD12849
Other clones	EK045225 EK062905 EK092960 EK099223 EK118951 EK129761 EK138343 EK140526 EK147218 EK159239 EK169959 EK173909 EK175702 EK192428 EK196941 EK208064 EK214447 EK215302 EK223829 EK233630 EK233718 EK251406 EK259335 EK267402 EK298009 EN05132 EP07457 EP11346 EP15426 FGC015A04 RH08971 RH09344 RP004128666 RP004174578 RP004238503 RP004242058 RP004255844 RP004259842 RP004273235 RP004344180 RP004357682 RP004408438 RP004476972 RP004537923
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025777 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33944
Antibody Information
	polyclonal (Diagana et al., 2002)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: homer CG11324 (Wortman, 1999.11)
Source for database merge of	Source for merge of: homer BEST:LD03829 (Bayraktaroglu, 2000.11.2)
Additional comments
Other Comments
	dsRNA made from templates generated with primers against this gene used in a genome-wide dsRNA interference (RNAi) screen to identify regulators of the signalling pathway leading from Ca2+-calcineurin to NFAT. (Gwack et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) homer operates in the ER and in dendrites to regulate the development and function of neural networks underlying locomotor control and behavioral plasticity. (Diagana et al., 2002) Mutants display defects in behavioural plasticity and the control of locomotor activity. (Diagana et al., 2002) Identification: Homer 1a sequence (from rat) was used to search GenBank databases, Drosophila sequence was identified. (Xiao et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058048 NM_164706 NM_001042876 NM_001273221 NM_001273222 NM_001273223 RefSeq (Proteins) • NP_477396 NP_723207 NP_001036341 NP_001260150 NP_001260151 NP_001260152 DDBJ / EMBL / GenBank • AA201147 AA202832 AAC71030 AAF52428 AAF52429 AAO49163 ABI31295 AC003052 AC092397 AF093266 AGB92686 AGB92687 AGB92688 AW941536 BT004910 CZ476769 Entrez Gene - A searchable database of RefSeq genes. • 33944 UniProtKB/TrEMBL • O96607 Q0E8S7 Q9VM94
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • EVH1 (IPR000697) Pleckstrin homology-like domain (IPR011993) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD03829
Linkouts
	BioGRID - A database of protein and genetic interactions • 60097 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025777 DroID - A comprehensive database of gene and protein interactions. • FBgn0025777 DRSC - Results from RNAi screens. • FBgn0025777 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025777 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11324-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025777 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33944 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/homer1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33944 modMine - Data generated by the modENCODE project. • FBgn0025777
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	BEST:LD03829   CG11324 (Roos et al., 2005, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) dhom (Babu et al., 2002) Dhom (Babu et al., 2002) Dhomer (Kaufmann et al., 2002, Babu et al., 2002) Dm Homer (Renfranz and Beckerle, 2002) Dvh   Hom (Bottenberg et al., 2009) homer (Hutchins and Rusconi, 2007, Roos et al., 2005, Izutsu et al., 2012, Zhang et al., 2006, Buszczak et al., 2007, Jungreis, 2011.11.18, Yang et al., 2008, Urizar et al., 2007, Ruedi and Hughes, 2009, Perkins et al., 2009.8.10, Rolls et al., 2007, Naidoo et al., 2012, Japanese National Institute of Genetics, 2012.5.21) Homer (Gwack et al., 2006) LD03829 (Toba et al., 1999)
Name Synonym	d-Homer (Cai et al., 2001) Drosophila Ves-1 homolog   homer (Rusconi et al., 2008, Yang et al., 2008) Homer (Bottenberg et al., 2009)
Secondary FlyBase IDs
	FBgn0026588
References ( 54 )
Generate a list of	All references relating to this gene ( 54 )
List References by type	Research paper  ( 18 ) Supplementary material  ( 8 ) Review  ( 4 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Website  ( 1 )
Recent research papers ( 2 )
	Izutsu et al., 2012, PLoS ONE 7(3): e33288 Genome features of "dark-fly", a Drosophila line reared long-term in a dark environment. [FBrf0217825] Naidoo et al., 2012, PLoS ONE 7(4): e35174 Role of homer proteins in the maintenance of sleep-wake States. [FBrf0218096] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...