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Gene Dmel\TBPH

General Information
Symbol	Dmel\TBPH	Species	D. melanogaster
Name	TAR DNA-binding protein-43 homolog	Annotation symbol	CG10327
Feature type	protein_coding_gene	FlyBase ID	FBgn0025790
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	TDP-43
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60A4-60A5	Sequence location	2R:19,746,590..19,750,135 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene TAR DNA-binding protein-43 homolog is referred to in FlyBase by the symbol Dmel\TBPH (CG10327, FBgn0025790). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. There is experimental evidence that it is involved in the biological process: negative regulation of synaptic growth at neuromuscular junction; central nervous system development; neuron projection morphogenesis; adult locomotory behavior; neuromuscular junction development. 22 alleles are reported. The phenotypes of these alleles are annotated with: eye; adult mushroom body; embryonic/larval neuromuscular junction; lobe system of mushroom body; ommatidium; axon. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval salivary gland, adult female reproductive system, adult testis. Gene sequence location is 2R:19746590..19750135.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms central nervous system development
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60A4-60A5   Limits computationally determined from genome sequence between P{lacW}eIF6k13214 and P{lacW}kenk11035&P{EP}CG17658EP730
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60A-60A     (Lukacsovich, 1998.11.11) 60A-60A     (Lukacsovich, 1998.1.8)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\TBPH for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Alternative translation stop created by use of multiphasic reading frames within coding region.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) TBPH-RA FBtr0089626  NM_058051   1705   332 TBPH-RB FBtr0089624  NM_058052   1915   531 TBPH-RC FBtr0089625  NM_134318   3210   531 TBPH-RD FBtr0089627  NM_166628   2175   531 TBPH-RE FBtr0301643  NM_001169809   2178   531 TBPH-RF FBtr0301644  NM_001169810   1918   531
Additional Transcript Data & Comments
Reported size (kB)	3.166, 1.916, 1.638 (longest cDNA) (Lukacsovich et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein TBPH-PA   FBpp0088569   37.7   332   6.42     NP_477399   AAF47080 TBPH-PB   FBpp0088567   58.1   531   7.15     NP_477400   AAF47079 TBPH-PC   FBpp0088568   58.1   531   7.15     NP_599145   AAF47078 TBPH-PD   FBpp0088570   58.1   531   7.15     NP_726373   AAM68274 TBPH-PE   FBpp0290857   58.1   531   7.15     NP_001163280   ACZ94552 TBPH-PF   FBpp0290858   58.1   531   7.15     NP_001163281   ACZ94553
Additional Polypeptide Data & Comments
Reported size (kDa)	531, 332 (aa) (Lukacsovich et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA940992   AE013599 AAF47078   AE013599 AAF47079   AE013599 AAF47080   AE013599 AAM68274   AB010261 BAA34421   AB010261 BAA34422   AB019705 BAA34428   AB019706 BAA34429   AB019707 BAA34430   AC004347   AC005267   AE013599 ACZ94552   AE013599 ACZ94553   AI113536   AI135721   AI238114   AI293499   AI403939   AI518319   AW941745   AY089497 AAL90235   AY118452   BG638360   BH901046   BI167144   BI169025   BI358315   BI363858   BI365418   BI568289   BI588379   BT022083   CL943493   CO154243   CO191024   CO195977   CO272070   CO278093   CO282345   CO292446   CO299226   CO302262   CO324791   CO329086   CO342534   EC063637   EC085739   EC086340   EC195043   EC197848   EC208773   EC209700   EC210880   EC216230   EC244432   EC254857   EC262800
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SXP8 Q9W1I0 O97468 O97469
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   hindgut anlage   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   inclusive hindgut primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Lukacsovich et al., 1999) pupal stage     (Lukacsovich et al., 1999)
Additional Descriptive Data
	TBPH transcripts are expressed at high levels in embryonic and pupal stages. (Lukacsovich et al., 1999) TBPH transcripts are expressed at high levels in embryonic and pupal stages. (Lukacsovich et al., 1999) TBPH transcripts are expressed at high levels in embryonic and pupal stages. (Lukacsovich et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference larval stage   embryonic/larval central nervous system | restricted   (Feiguin et al., 2009) embryonic/larval optic lobe   (Feiguin et al., 2009) embryonic/larval brain   (Feiguin et al., 2009) ventral nerve cord   (Feiguin et al., 2009) adult stage   optic lobe   (Feiguin et al., 2009) adult brain   (Feiguin et al., 2009) adult central nervous system | restricted   (Feiguin et al., 2009) thoracico-abdominal ganglion   (Feiguin et al., 2009)
Additional Descriptive Data
	TBPH is highly expressed in neuronal tissues in developmental stages and in adults. (Feiguin et al., 2009)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Lin et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval salivary gland, adult female reproductive system, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    32 central nervous system, pupae P8    27 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    17 carcass, larvae L3 wandering    17 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    12 ovary, mated 4-day female    11 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (32) central nervous system, larvae L3  (32) central nervous system, pupae P8  (27) head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    17 carcass, larvae L3 wandering    17 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    12 ovary, mated 4-day female    11 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    32 central nervous system, pupae P8    27 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    17 carcass, larvae L3 wandering    17 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    12 ovary, mated 4-day female    11 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    32 central nervous system, pupae P8    27 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    17 carcass, larvae L3 wandering    17 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    12 ovary, mated 4-day female    11 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    32 central nervous system, pupae P8    27 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    17 carcass, larvae L3 wandering    17 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    12 ovary, mated 4-day female    11 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  32 central nervous system, larvae L3  32 central nervous system, pupae P8  27 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    17 carcass, larvae L3 wandering    17 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    12 ovary, mated 4-day female    11 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    32 central nervous system, pupae P8    27 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    17 carcass, larvae L3 wandering    17 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    12 ovary, mated 4-day female    11 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    32 central nervous system, pupae P8    27 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    11 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    19 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    17 carcass, larvae L3 wandering    17 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    12 ovary, mated 4-day female    11 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    36 embryo 04-06hr    65 embryo 06-08hr    67 embryo 08-10hr    51 embryo 10-12hr    50 embryo 12-14hr    38 embryo 14-16hr    32 embryo 16-18hr    26 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    24 white prepupae new    26 white prepupae 12hr    28 white prepupae 24hr    33 pupae 2d postWPP    29 pupae 3d postWPP    19 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    16 adult female 01day    13 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr  (36) embryo 04-06hr  (65) embryo 06-08hr  (67) embryo 08-10hr  (51) embryo 10-12hr  (50) embryo 12-14hr  (38) embryo 14-16hr  (32) embryo 16-18hr  26 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    24 white prepupae new  26 white prepupae 12hr  (28) white prepupae 24hr  (33) pupae 2d postWPP  (29) pupae 3d postWPP    19 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    16 adult female 01day    13 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    36 embryo 04-06hr    65 embryo 06-08hr    67 embryo 08-10hr    51 embryo 10-12hr    50 embryo 12-14hr    38 embryo 14-16hr    32 embryo 16-18hr    26 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    24 white prepupae new    26 white prepupae 12hr    28 white prepupae 24hr    33 pupae 2d postWPP    29 pupae 3d postWPP    19 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    16 adult female 01day    13 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    36 embryo 04-06hr    65 embryo 06-08hr    67 embryo 08-10hr    51 embryo 10-12hr    50 embryo 12-14hr    38 embryo 14-16hr    32 embryo 16-18hr    26 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    24 white prepupae new    26 white prepupae 12hr    28 white prepupae 24hr    33 pupae 2d postWPP    29 pupae 3d postWPP    19 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    16 adult female 01day    13 adult female 05day    13 adult female 30day    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    36 embryo 04-06hr    65 embryo 06-08hr    67 embryo 08-10hr    51 embryo 10-12hr    50 embryo 12-14hr    38 embryo 14-16hr    32 embryo 16-18hr    26 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    24 white prepupae new    26 white prepupae 12hr    28 white prepupae 24hr    33 pupae 2d postWPP    29 pupae 3d postWPP    19 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    16 adult female 01day    13 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr  (36) embryo 04-06hr  (65) embryo 06-08hr  (67) embryo 08-10hr  (51) embryo 10-12hr  (50) embryo 12-14hr  (38) embryo 14-16hr  32 embryo 16-18hr  26 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    24 white prepupae new  26 white prepupae 12hr  28 white prepupae 24hr  (33) pupae 2d postWPP  29 pupae 3d postWPP    19 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    16 adult female 01day    13 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    36 embryo 04-06hr    65 embryo 06-08hr    67 embryo 08-10hr    51 embryo 10-12hr    50 embryo 12-14hr    38 embryo 14-16hr    32 embryo 16-18hr    26 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    24 white prepupae new    26 white prepupae 12hr    28 white prepupae 24hr    33 pupae 2d postWPP    29 pupae 3d postWPP    19 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    16 adult female 01day    13 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    36 embryo 04-06hr    65 embryo 06-08hr    67 embryo 08-10hr    51 embryo 10-12hr    50 embryo 12-14hr    38 embryo 14-16hr    32 embryo 16-18hr    26 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    20 larva L2    13 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    24 white prepupae new    26 white prepupae 12hr    28 white prepupae 24hr    33 pupae 2d postWPP    29 pupae 3d postWPP    19 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    16 adult female 01day    13 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    22 embryonic 1182-4H    15 embryonic GM2    14 embryonic Kc167    11 embryonic S1    22 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    14 wing disc ML-DmD8    15 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    17 ovary fGS/OSS    22 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    22 embryonic 1182-4H    15 embryonic GM2    14 embryonic Kc167    11 embryonic S1    22 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    14 wing disc ML-DmD8    15 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3  (35) eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    17 ovary fGS/OSS    22 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    22 embryonic 1182-4H    15 embryonic GM2    14 embryonic Kc167    11 embryonic S1    22 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    14 wing disc ML-DmD8    15 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    17 ovary fGS/OSS    22 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    22 embryonic 1182-4H    15 embryonic GM2    14 embryonic Kc167    11 embryonic S1    22 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    14 wing disc ML-DmD8    15 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    17 ovary fGS/OSS    22 ovary OSC    12 ovary OSS    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    22 embryonic 1182-4H    15 embryonic GM2    14 embryonic Kc167    11 embryonic S1    22 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    14 wing disc ML-DmD8    15 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    17 ovary fGS/OSS    22 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    22 embryonic 1182-4H    15 embryonic GM2    14 embryonic Kc167    11 embryonic S1    22 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    14 wing disc ML-DmD8    15 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3  (35) eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    17 ovary fGS/OSS    22 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    22 embryonic 1182-4H    15 embryonic GM2    14 embryonic Kc167    11 embryonic S1    22 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    14 wing disc ML-DmD8    15 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    17 ovary fGS/OSS    22 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    22 embryonic 1182-4H    15 embryonic GM2    14 embryonic Kc167    11 embryonic S1    22 embryonic S3    17 leg disc CME L1    21 wing disc CME-W2    14 wing disc ML-DmD8    15 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    17 ovary fGS/OSS    22 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    11 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    11 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    11 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    11 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    11 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    11 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    11 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    11 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GH09868 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025790 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10327-RD;CG10327-RC FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for TBPH Stages(s) 1-3 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(2R)or-BR11) TBPHG2 lethal | larval stage | heat sensitive, with Scer\GAL4GMR.PF TBPHScer\UAS.T:Avic\GFP TBPHScer\UAS.T:Disc\RFP lethal | pharate adult stage | recessive TBPHΔ23 TBPHΔ142 lethal | pupal stage TBPHG2 lethal | pupal stage | heat sensitive, with Scer\GAL4GMR.PF TBPHA405T.Scer\UAS.T:Disc\RFP TBPHScer\UAS.T:Avic\GFP TBPHScer\UAS.T:Disc\RFP partially lethal - majority die (with Df(2R)BSC660) TBPHΔ23 partially lethal - majority die | pharate adult stage TBPHex26 viable TBPHEY10530 TBPHKG08578 viable, with Scer\GAL4ey-OK107 TBPHGD6943 TBPHScer\UAS.cLa viable, with Scer\GAL4pnr-MD237 TBPHGD6943 viable (with Df(2R)or-BR11) TBPHKG08578 Sterility Allele fertile TBPHEY10530 Other Phenotypes Allele gravitaxis defective, with Scer\GAL4D42 TBPHGD6943 increased cell death, with Scer\GAL4ey-OK107 TBPHGD6943 increased cell death, with Scer\GAL4GMR.PF TBPHScer\UAS.cRa increased cell death | larval stage, with Scer\GAL4D42 TBPHA405T.Scer\UAS.T:Disc\RFP TBPHScer\UAS.T:Avic\GFP TBPHScer\UAS.T:Disc\RFP learning defective | adult stage, with Scer\GAL4ey-OK107 TBPHGD6943 TBPHScer\UAS.cLa locomotor behavior defective TBPHGD6943 locomotor behavior defective, with Scer\GAL4elav.PLu TBPHGD6943 locomotor behavior defective, with Scer\GAL4elav.PLu, TBPHGD6943 TBPHΔ23 locomotor behavior defective, with Scer\GAL4elav.PLu, TBPHΔ23 TBPHGD6943 locomotor behavior defective (with Df(2R)BSC660) TBPHΔ23 locomotor behavior defective | adult stage TBPHex26 locomotor behavior defective | adult stage, with Scer\GAL4D42 TBPHScer\UAS.cHa TBPHScer\UAS.cLa locomotor behavior defective | adult stage | recessive TBPHΔ23 TBPHΔ142 locomotor behavior defective | larval stage, with Scer\GAL4D42 TBPHScer\UAS.cLa locomotor behavior defective | larval stage, with Scer\GAL4elav.PU TBPHGD6943 locomotor behavior defective | third instar larval stage TBPHex26 TBPHG2 locomotor behavior defective | third instar larval stage, with Scer\GAL4D42 TBPHA405T.Scer\UAS.T:Disc\RFP TBPHGD6943 TBPHScer\UAS.T:Avic\GFP TBPHScer\UAS.T:Disc\RFP neuroanatomy defective, with Scer\GAL4ey-OK107 TBPHGD6943 neuroanatomy defective, with Scer\GAL4Rapgap1-OK6 TBPHScer\UAS.10x.T:Avic\GFP-YFP.Venus neuroanatomy defective | adult stage, with Scer\GAL4GMR.PF TBPHA405T.Scer\UAS.T:Disc\RFP TBPHScer\UAS.T:Avic\GFP TBPHScer\UAS.T:Disc\RFP neuroanatomy defective | larval stage, with Scer\GAL4D42 TBPHA405T.Scer\UAS.T:Disc\RFP TBPHScer\UAS.T:Avic\GFP TBPHScer\UAS.T:Disc\RFP neuroanatomy defective | third instar larval stage TBPHex26 TBPHΔ23 TBPHΔ142 neuroanatomy defective | third instar larval stage, with Scer\GAL4D42 TBPHScer\UAS.cLa neuroanatomy defective | third instar larval stage, with Scer\GAL4elav.PU TBPHGD6943 short lived TBPHΔ23 TBPHΔ142 short lived, with Scer\GAL4D42 TBPHGD6943 short lived (with Df(2R)BSC660) TBPHΔ23 visible | adult stage, with Scer\GAL4GMR.PF TBPHScer\UAS.T:Avic\GFP Phenotype manifest in Allele adult mushroom body, with Scer\GAL4ey-OK107 TBPHGD6943 axon, with Scer\GAL4ey-OK107 TBPHGD6943 embryonic/larval neuromuscular junction TBPHΔ23 TBPHΔ142 embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4D42 TBPHScer\UAS.T:Avic\GFP TBPHA405T.Scer\UAS.T:Disc\RFP TBPHScer\UAS.T:Disc\RFP embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Rapgap1-OK6 TBPHScer\UAS.10x.T:Avic\GFP-YFP.Venus eye, with Scer\GAL4GMR.PF TBPHScer\UAS.T:Avic\GFP TBPHA405T.Scer\UAS.T:Disc\RFP TBPHScer\UAS.T:Disc\RFP TBPHScer\UAS.cRa lobe system of mushroom body, with Scer\GAL4ey-OK107 TBPHScer\UAS.cLa motor neuron | larval stage, with Scer\GAL4D42 TBPHScer\UAS.T:Avic\GFP TBPHA405T.Scer\UAS.T:Disc\RFP TBPHScer\UAS.T:Disc\RFP NMJ bouton | larval stage, with Scer\GAL4D42 TBPHScer\UAS.T:Avic\GFP TBPHScer\UAS.T:Disc\RFP NMJ bouton | third instar larval stage TBPHex26 NMJ bouton | third instar larval stage, with Scer\GAL4D42 TBPHScer\UAS.cLa NMJ bouton | third instar larval stage, with Scer\GAL4elav.PU TBPHGD6943 ommatidium, with Scer\GAL4GMR.PF TBPHScer\UAS.cRa synaptic vesicle | larval stage, with Scer\GAL4D42 TBPHScer\UAS.T:Avic\GFP TBPHA405T.Scer\UAS.T:Disc\RFP TBPHScer\UAS.T:Disc\RFP type I bouton | third instar larval stage TBPHΔ23 TBPHΔ142
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of TBPH Class Mutagen Stocks Known lesion TBPHEY10530 P-element activity 1 -- TBPHKG08578 P-element activity 1 -- TBPHex26 amorphic allele - molecular evidence P-element activity 0 Yes TBPHG2 amorphic allele - molecular evidence P-element activity 0 Yes TBPH1 P-element activity 0 Yes TBPHA1 P-element activity 0 Yes TBPHΔ142 Delta2-3 0 Yes TBPHΔ23 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of TBPH Class Mutagen Stocks Known lesion TBPHGD6943 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes TBPHHM05194 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TBPHHMS01932 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TBPHKK108354 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TBPHA405T.Scer\UAS.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes TBPHGD17745 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes TBPHNIG.10327R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes TBPHScer\UAS.10x.T:Avic\GFP-YFP.Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TBPHScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes TBPHScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes TBPHScer\UAS.cRa in vitro construct - regulatory fusion 0 Yes TBPHScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TBPHScer\UAS.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TBPHScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{10xUAS-YFP.Venus} NA P{GD6943} NA P{GD17745} NA P{KK108354} NA P{NIG.10327R} NA P{TRiP.HM05194} NA P{TRiP.HMS01932} NA P{UAS-TBPH.A405T.RFP} NA P{UAS-TBPH.Flag} NA P{UAS-TBPH.GFP} NA P{UAS-TBPH.H} NA P{UAS-TBPH.L} NA P{UAS-TBPH.R} NA P{UAS-TBPH.RFP} NA GAL4 construct P{TBPH-GAL4.H} No
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}TBPHEY10530 NA miscellaneous insertions P{?EPgy2}TBPHΔ142 NA P{SUPor-P}TBPHKG08578 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
adult locomotory behavior inferred from mutant phenotype (Feiguin et al., 2009, Wang et al., 2011) central nervous system development inferred from mutant phenotype (Li et al., 2010) negative regulation of synaptic growth at neuromuscular junction inferred from mutant phenotype (Lin et al., 2011) neuromuscular junction development inferred from mutant phenotype (Feiguin et al., 2009) neuron projection morphogenesis inferred from mutant phenotype (Sepp et al., 2008)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Lin et al., 2011)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR000504 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
TBPH - CG1140 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) TBPH - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) TBPH - CG18789 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) TBPH - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) TBPH - caz anti tag coimmunoprecipitation, anti tag western blot (Wang et al., 2011) TBPH - mRpS7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) TBPH - vkg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions TBPH allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63374 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025790 DroID - A comprehensive database of gene and protein interactions. • FBgn0025790 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37781
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6TF152 Dipteran inclusive ortholog search EOG6Z0BF6 Insect inclusive ortholog search EOG61JX7G Arthropod inclusive ortholog search EOG6RR4ZM Metazoa inclusive ortholog search EOG6H7F6N
Orthologs in Drosophila Species (EOG6TF152)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\TBPH     Drosophila simulans   Dsim\GD25005 Y   Drosophila sechellia   Dsec\GM15502 Y   Drosophila erecta   Dere\GG19989 Y   Drosophila yakuba   Dyak\GE11522 Y   Drosophila ananassae   Dana\GF12452 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10247 Y   Drosophila persimilis   Dper\GL10927 Y   Drosophila willistoni   Dwil\GK15864 Y   Drosophila virilis   Dvir\GJ21868 Y   Drosophila mojavensis   Dmoj\GI20724 Y   Drosophila grimshawi   Dgri\GH20198 Y
Orthologs in non-Drosophila Dipterans (EOG6Z0BF6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Anopheles gambiae Malaria mosquito  Agam\AGAP003497 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014288 Y
Orthologs in non-Dipteran Insects (EOG61JX7G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43827 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011940 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011941 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH27095 Y Atta cephalotes Leafcutter ant  Acep\ACEP14450 Y Atta cephalotes Leafcutter ant  Acep\ACEP14439 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16637 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15349 Y Linepithema humile Argentine ant  Lhum\LH20315 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB23251 Y Solenopsis invicta Red fire ant  Sinv\SINV16760 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004992 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004191 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007518 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006832 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012007 Y Pediculus humanus Human body louse  Phum\PHUM575260 Y Tribolium castaneum Red flour beetle  Tcas\TC006055 Y
Orthologs in non-Insect Arthropods (EOG6RR4ZM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_97182 Y Ixodes scapularis Deer tick  Isca\ISCW012027 Y Ixodes scapularis Deer tick  Isca\ISCW012026 Y
Orthologs in non-Arthropod Metazoa (EOG6H7F6N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\tdp-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022940gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005628gn Y Danio rerio Zebrafish  Drer\tardbp Y Danio rerio Zebrafish  Drer\tardbpl Y Xenopus tropicalis Western clawed frog  Xtro\tardbp Y Gallus gallus Domestic chicken  Ggal\TARDBP Y Mus musculus House mouse  Mmus\Tardbp Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000012455 Y Homo sapiens Human  Hsap\TARDBP Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\TARDBP
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25005 Drosophila sechellia Dsec\GM15502 Drosophila erecta Dere\GG19989 Drosophila yakuba Dyak\GE11522 Drosophila ananassae Dana\GF12452 Drosophila pseudoobscura pseudoobscura Dpse\GA10247 Drosophila persimilis Dper\GL10927 Drosophila willistoni Dwil\GK15864 Drosophila virilis Dvir\GJ21868 Drosophila mojavensis Dmoj\GI20724 Drosophila grimshawi Dgri\GH20198
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	14737 y1; P{SUPor-P}TBPHKG08578 29517 y1 v1; P{TRiP.HM05194}attP2 39014 y1 v1; P{TRiP.HMS01932}attP40 20801 y1 w67c23; P{EPgy2}TBPHEY10530
VDRC	v104401 P{KK108354}VIE-260B v38377 w1118; P{GD6943}v38377 v38379 w1118; P{GD6943}v38379
Genomic Clones ( 1 )
	BACR05F24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT09813 GH09868 RH39704
Other clones	DPiM_GH09868
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH13570 GH14113 GH23490 LD37796 LP06661 RE07464 RE09981 RE45050 RE48824 RE50724 RH29574
Other clones	7836 17174 28962 44083 59193 67030 71862 191262 214353.72 523296 CK01.32A.E4 CK01.131A.G4 EC43789 EK050504 EK105747 EK128730 EK160256 EK174830 EK183752 EK194840 EK200211 EK292014 EN03763 EP15059 LD23410
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025790 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37781
Antibody Information
	polyclonal (Ritson et al., 2010, Lin et al., 2011, Feiguin et al., 2009, Hazelett et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: TBPH CG10327 (Zheng, 1999.11)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058051 NM_058052 NM_134318 NM_166628 NM_001169809 NM_001169810 RefSeq (Proteins) • NP_477399 NP_477400 NP_599145 NP_726373 NP_001163280 NP_001163281 DDBJ / EMBL / GenBank • AA940992 AAF47078 AAF47079 AAF47080 AAL90235 AAM68274 AB010261 AB019705 AB019706 AB019707 AC004347 AC005267 ACZ94552 ACZ94553 AI113536 AI135721 AW941745 AY089497 BAA34421 BAA34422 BAA34428 BAA34429 BAA34430 BG638360 BH901046 BI568289 CL943493 Entrez Gene - A searchable database of RefSeq genes. • 37781 UniProtKB/TrEMBL • O97468 O97469 Q8SXP8 Q9W1I0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH09868
Linkouts
	BioGRID - A database of protein and genetic interactions • 63374 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025790 DroID - A comprehensive database of gene and protein interactions. • FBgn0025790 DRSC - Results from RNAi screens. • FBgn0025790 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025790 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10327-RD;CG10327-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025790 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37781 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37781 modMine - Data generated by the modENCODE project. • FBgn0025790
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG10327 (Mount, 2001.8.14, Keleman et al., 2009.8.5, Gandhi et al., 2007, Perkins et al., 2009, Ritson et al., 2010, Zhan et al., 2011, Sepp et al., 2008, Ni et al., 2010.12.1) dtar (Ohlstein et al., 2000) dTDP (Lin et al., 2011) Pi3K92E (Korenjak et al., 2012) TBPH (Li et al., 2010, Hazelett et al., 2012, Sofola et al., 2007, Lin et al., 2011, Godena et al., 2011, Peng et al., 2007, Still et al., 2004, Feiguin et al., 2009, Ritson et al., 2010, Voigt et al., 2010, Estes et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Sepp et al., 2008) tbph (Sofola et al., 2007, Wang et al., 2011) TDP-43 (Fiesel et al., 2010, Ritson et al., 2010, Estes et al., 2011) TDP43 (Ayala et al., 2005)
Name Synonym	TAR DNA binding protein (Ayala et al., 2005) TAR DNA-binding protein-43 homolog   Tar DNA binding protein homolog (Li et al., 2010) TBPH
Secondary FlyBase IDs
References ( 51 )
Generate a list of	All references relating to this gene ( 51 )
List References by type	Research paper  ( 26 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 4 ) Website  ( 1 )
Recent research papers ( 11 )
	Vanden Broeck et al., 2013, Cell Rep. 3(1): 160--172 TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophila. [FBrf0220703] Zhan et al., 2013, PLoS ONE 8(2): e57214 Identification of Genetic Modifiers of TDP-43 Neurotoxicity in Drosophila. [FBrf0220979] Adamson and Lajeunesse, 2012, ScientificWorldJournal 2012: 347597 A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System. [FBrf0218446] Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Korenjak et al., 2012, Mol. Cell. Biol. 32(21): 4375--4387 RBF Binding to both Canonical E2F Targets and Noncanonical Targets Depends on Functional dE2F/dDP Complexes. [FBrf0219643] Wang et al., 2012, PLoS ONE 7(7): e42102 A modular toolset for recombination transgenesis and neurogenetic analysis of Drosophila. [FBrf0219026] Estes et al., 2011, Hum. Mol. Genet. 20(12): 2308--2321 Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. [FBrf0213802] Godena et al., 2011, PLoS ONE 6(3): e17808 TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating Futsch/MAP1B Levels and Synaptic Microtubules Organization. [FBrf0213270] Lin et al., 2011, PLoS ONE 6(6): e20371 Neuronal Function and Dysfunction of Drosophila dTDP. [FBrf0213971] Wang et al., 2011, J. Clin. Invest. 121(10): 4118--4126 The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. [FBrf0216240] Zhan et al., 2011, Gene 470(1-2): 1--6 Evolution of alternative splicing in newly evolved genes of Drosophila. [FBrf0212278] Show all research papers ...