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Gene Dmel\Smox

General Information
Symbol	Dmel\Smox	Species	D. melanogaster
Name	Smad on X	Annotation symbol	CG2262
Feature type	protein_coding_gene	FlyBase ID	FBgn0025800
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	dSmad2, SMAD2, Sad
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	7D14-7D15	Sequence location	X:8,032,424..8,036,301 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Smad on X is referred to in FlyBase by the symbol Dmel\Smox (CG2262, FBgn0025800). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: axon guidance; neuron development; regulation of mitotic cell cycle; mushroom body development; imaginal disc-derived wing morphogenesis. 16 alleles are reported. The phenotypes of these alleles are annotated with: medulla neuropil; lamina anlage glial cell; medulla neuropil glial cell; larval inner optic anlage; larval outer optic anlage; chaeta; wing; lamina. It has one annotated transcript and one annotated polypeptide. Protein features are: Dwarfin; MAD homology 1, Dwarfin-type; MAD homology, MH1; SMAD domain, Dwarfin-type; SMAD domain-like; SMAD/FHA domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1629290_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Smox. Gene sequence location is X:8032424..8036301.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Controlled Vocabulary Terms protein binding Sequence features BKN46377 BKN31163 HFA18716
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7D14-7D15   Limits computationally determined from genome sequence between P{EP}Ubc-E2HEP1303 and P{EP}CG1583EP1516&P{EP}CG1583EP325
Experimentally Determined Cytological Location
Cytogenetic map Notes References 7D-7D   (determined by in situ hybridisation)   (Peter et al., 2002) 7D10-7D12     (Zheng et al., 2003) 7D-7D   (determined by in situ hybridisation)   (Schaefer et al., 1999.12.2) 7D7-7D16     (Henderson, 1998.7.15) 7D-7D     (Das, 1998.11.23) 7D-7D     (Brummel, 1998.10.26) 7D-7D   (determined by in situ hybridisation)   (Henderson and Andrew, 1998) 7D7-7D16     (Andrew, 1998.3.10) 7D6-7D17   Mapped to 7D6--7D17 using grids of P1 clones.   (Das et al., 1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Smox for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Smox-RA FBtr0071192  NM_078524   3160   486
Additional Transcript Data & Comments
Reported size (kB)	~4.5 (northern blot) (Henderson and Andrew, 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Smox-PA   FBpp0071140   53.7   486   7.63     NP_511079   AAF46330
Additional Polypeptide Data & Comments
Reported size (kDa)	486 (aa) (Brummel et al., 1999) 484 (aa) (Henderson and Andrew, 1998)
Comments	Activated babo protein phosphorylates the C-terminal SSXS motif of Smox protein. Med and Smox proteins form some complexes in the absence of activated babo protein, but the level of complex formation increases significantly in the presence of the activated babo protein. Smox protein also interacts transiently with put-:-babo protein complexes. (Brummel et al., 1999)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SMAD domain, Dwarfin-type (IPR001132) MAD homology 1, Dwarfin-type (IPR003619) SMAD/FHA domain (IPR008984) MAD homology, MH1 (IPR013019) Dwarfin (IPR013790) SMAD domain-like (IPR017855)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141008   AA141009   AA567647   AE014298 AAF46330   AF078529 AAC83344   AF101386 AAD11458   AF109132 AAD22443   AJ426765   AQ073211   BF504755   BI162122   BI162123   BI162124   BI170538   BI215017   BI230882   BI367685   BI369813   BI371095   BI573844   BI573845   BI610103   BI614666   BI622544   BI623827   BP550034   BP550035   BT004858 AAO45214   BT016105 AAV36990   CK661385   CO177448   CO177450   CO179543   CO179544   CO190803   CO190804   CO191035   CO271669   CO274944   CO276435   CO280511   CO294575   CO299051   CO308241   CO311559   CO312935   CO320515   CO321976   CO337420   CO340553   EC054292   EC056246   EC057523   EC061834   EC071624   EC075527   EC085870   EC088998   EC195613   EC202535   EC217846   EC217847   EC224413   EC232066   EC236777   EC238167   EC239228   EC243338   EC247266   EC254639   EC262438   ES696464   ES696466   EV579520   EV586307   EV590161
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O96660 Q86NL2 Q9TZQ2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Henderson and Andrew, 1998) embryonic stage -- adult stage     (Henderson and Andrew, 1998) pre-blastoderm stage   organism   (Brummel et al., 1999) embryonic stage 6 -- 17   mesoderm   (Brummel et al., 1999) third instar larval stage   embryonic/larval brain | restricted   (Brummel et al., 1999) imaginal disc   (Brummel et al., 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Henderson and Andrew, 1998) embryonic stage 1 -- 4     (Henderson and Andrew, 1998) Comment:reference states 0-2 hr AEL adult stage | female     (Henderson and Andrew, 1998)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0025800    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0025800 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0025800 expression level Developmental Stage   Expression Level embryo 00-02hr    2703 embryo 02-04hr    1030 embryo 04-06hr    654 embryo 06-08hr    829 embryo 08-10hr    880 embryo 10-12hr    982 embryo 12-14hr    1285 embryo 14-16hr    1355 embryo 16-18hr    1476 embryo 18-20hr    2260 embryo 20-22hr    2234 embryo 22-24hr    2448 larva L1    1740 larva L2    1474 larva L3 12hr old    1409 larva L3 puffstage 1-2    1213 larva L3 puffstage 3-6    2588 larva L3 puffstage 7-9    2477 white prepupae new    2607 white prepupae 12hr    2934 white prepupae 24hr    3103 pupae 2d postWPP    1766 pupae 3d postWPP    1187 pupae 4d postWPP    1520 adult male 01day    1605 adult male 05day    1851 adult male 30day    1579 adult female 01day    2020 adult female 05day    2398 adult female 30day    2431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2703) embryo 02-04hr  (1030) embryo 04-06hr  (654) embryo 06-08hr  (829) embryo 08-10hr  (880) embryo 10-12hr  (982) embryo 12-14hr  (1285) embryo 14-16hr  (1355) embryo 16-18hr  (1476) embryo 18-20hr  (2260) embryo 20-22hr  (2234) embryo 22-24hr  (2448) larva L1  (1740) larva L2  (1474) larva L3 12hr old  (1409) larva L3 puffstage 1-2  (1213) larva L3 puffstage 3-6  (2588) larva L3 puffstage 7-9  (2477) white prepupae new  (2607) white prepupae 12hr  (2934) white prepupae 24hr  (3103) pupae 2d postWPP  (1766) pupae 3d postWPP  (1187) pupae 4d postWPP  (1520) adult male 01day  (1605) adult male 05day  (1851) adult male 30day  (1579) adult female 01day  (2020) adult female 05day  (2398) adult female 30day  (2431) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2703) embryo 02-04hr    1030 embryo 04-06hr    654 embryo 06-08hr    829 embryo 08-10hr    880 embryo 10-12hr    982 embryo 12-14hr    1285 embryo 14-16hr    1355 embryo 16-18hr  1476 embryo 18-20hr  (2260) embryo 20-22hr  (2234) embryo 22-24hr  (2448) larva L1  (1740) larva L2  1474 larva L3 12hr old  1409 larva L3 puffstage 1-2    1213 larva L3 puffstage 3-6  (2588) larva L3 puffstage 7-9  (2477) white prepupae new  (2607) white prepupae 12hr  (2934) white prepupae 24hr  (3103) pupae 2d postWPP  (1766) pupae 3d postWPP    1187 pupae 4d postWPP  (1520) adult male 01day  (1605) adult male 05day  (1851) adult male 30day  (1579) adult female 01day  (2020) adult female 05day  (2398) adult female 30day  (2431) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2703 embryo 02-04hr    1030 embryo 04-06hr    654 embryo 06-08hr    829 embryo 08-10hr    880 embryo 10-12hr    982 embryo 12-14hr    1285 embryo 14-16hr    1355 embryo 16-18hr    1476 embryo 18-20hr    2260 embryo 20-22hr    2234 embryo 22-24hr    2448 larva L1    1740 larva L2    1474 larva L3 12hr old    1409 larva L3 puffstage 1-2    1213 larva L3 puffstage 3-6    2588 larva L3 puffstage 7-9    2477 white prepupae new    2607 white prepupae 12hr    2934 white prepupae 24hr    3103 pupae 2d postWPP    1766 pupae 3d postWPP    1187 pupae 4d postWPP    1520 adult male 01day    1605 adult male 05day    1851 adult male 30day    1579 adult female 01day    2020 adult female 05day    2398 adult female 30day    2431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2703 embryo 02-04hr    1030 embryo 04-06hr    654 embryo 06-08hr    829 embryo 08-10hr    880 embryo 10-12hr    982 embryo 12-14hr    1285 embryo 14-16hr    1355 embryo 16-18hr    1476 embryo 18-20hr    2260 embryo 20-22hr    2234 embryo 22-24hr    2448 larva L1    1740 larva L2    1474 larva L3 12hr old    1409 larva L3 puffstage 1-2    1213 larva L3 puffstage 3-6    2588 larva L3 puffstage 7-9    2477 white prepupae new    2607 white prepupae 12hr    2934 white prepupae 24hr    3103 pupae 2d postWPP    1766 pupae 3d postWPP    1187 pupae 4d postWPP    1520 adult male 01day    1605 adult male 05day    1851 adult male 30day    1579 adult female 01day    2020 adult female 05day    2398 adult female 30day    2431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0025800 expression level Developmental Stage   Expression Level embryo 00-02hr    2703 embryo 02-04hr    1030 embryo 04-06hr    654 embryo 06-08hr    829 embryo 08-10hr    880 embryo 10-12hr    982 embryo 12-14hr    1285 embryo 14-16hr    1355 embryo 16-18hr    1476 embryo 18-20hr    2260 embryo 20-22hr    2234 embryo 22-24hr    2448 larva L1    1740 larva L2    1474 larva L3 12hr old    1409 larva L3 puffstage 1-2    1213 larva L3 puffstage 3-6    2588 larva L3 puffstage 7-9    2477 white prepupae new    2607 white prepupae 12hr    2934 white prepupae 24hr    3103 pupae 2d postWPP    1766 pupae 3d postWPP    1187 pupae 4d postWPP    1520 adult male 01day    1605 adult male 05day    1851 adult male 30day    1579 adult female 01day    2020 adult female 05day    2398 adult female 30day    2431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2703) embryo 02-04hr  (1030) embryo 04-06hr  (654) embryo 06-08hr  (829) embryo 08-10hr  (880) embryo 10-12hr  (982) embryo 12-14hr  (1285) embryo 14-16hr  (1355) embryo 16-18hr  (1476) embryo 18-20hr  (2260) embryo 20-22hr  (2234) embryo 22-24hr  (2448) larva L1  (1740) larva L2  (1474) larva L3 12hr old  (1409) larva L3 puffstage 1-2  (1213) larva L3 puffstage 3-6  (2588) larva L3 puffstage 7-9  (2477) white prepupae new  (2607) white prepupae 12hr  (2934) white prepupae 24hr  (3103) pupae 2d postWPP  (1766) pupae 3d postWPP  (1187) pupae 4d postWPP  (1520) adult male 01day  (1605) adult male 05day  (1851) adult male 30day  (1579) adult female 01day  (2020) adult female 05day  (2398) adult female 30day  (2431) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2703) embryo 02-04hr    1030 embryo 04-06hr    654 embryo 06-08hr    829 embryo 08-10hr    880 embryo 10-12hr    982 embryo 12-14hr    1285 embryo 14-16hr    1355 embryo 16-18hr  1476 embryo 18-20hr  2260 embryo 20-22hr  2234 embryo 22-24hr  2448 larva L1  1740 larva L2  1474 larva L3 12hr old  1409 larva L3 puffstage 1-2    1213 larva L3 puffstage 3-6  (2588) larva L3 puffstage 7-9  (2477) white prepupae new  (2607) white prepupae 12hr  (2934) white prepupae 24hr  (3103) pupae 2d postWPP  1766 pupae 3d postWPP    1187 pupae 4d postWPP  1520 adult male 01day  1605 adult male 05day  1851 adult male 30day  1579 adult female 01day  2020 adult female 05day  2398 adult female 30day  2431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2703 embryo 02-04hr    1030 embryo 04-06hr    654 embryo 06-08hr    829 embryo 08-10hr    880 embryo 10-12hr    982 embryo 12-14hr    1285 embryo 14-16hr    1355 embryo 16-18hr    1476 embryo 18-20hr    2260 embryo 20-22hr    2234 embryo 22-24hr    2448 larva L1    1740 larva L2    1474 larva L3 12hr old    1409 larva L3 puffstage 1-2    1213 larva L3 puffstage 3-6    2588 larva L3 puffstage 7-9    2477 white prepupae new    2607 white prepupae 12hr    2934 white prepupae 24hr    3103 pupae 2d postWPP    1766 pupae 3d postWPP    1187 pupae 4d postWPP    1520 adult male 01day    1605 adult male 05day    1851 adult male 30day    1579 adult female 01day    2020 adult female 05day    2398 adult female 30day    2431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2703 embryo 02-04hr    1030 embryo 04-06hr    654 embryo 06-08hr    829 embryo 08-10hr    880 embryo 10-12hr    982 embryo 12-14hr    1285 embryo 14-16hr    1355 embryo 16-18hr    1476 embryo 18-20hr    2260 embryo 20-22hr    2234 embryo 22-24hr    2448 larva L1    1740 larva L2    1474 larva L3 12hr old    1409 larva L3 puffstage 1-2    1213 larva L3 puffstage 3-6    2588 larva L3 puffstage 7-9    2477 white prepupae new    2607 white prepupae 12hr    2934 white prepupae 24hr    3103 pupae 2d postWPP    1766 pupae 3d postWPP    1187 pupae 4d postWPP    1520 adult male 01day    1605 adult male 05day    1851 adult male 30day    1579 adult female 01day    2020 adult female 05day    2398 adult female 30day    2431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0025800    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0025800 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0025800 expression level Tissue   Expression Level Larval Central Nervous System    311.45 Larval Midgut    173.1 Larval Hindgut    164.8 Larval Malpighian Tubules    131.6 Larval Fat Body    108.1 Larval Salivary Gland    104.3 Larval Trachea    204.925 Larval Carcass    102.45 Adult Head    96.2 Adult Eye    190.85 Adult Brain    114.7 Adult Thoracic-Abdominal Ganglion    89.4 Adult Crop    145.1 Adult Midgut    94.9 Adult Hindgut    113.3 Adult Malpighian Tubules    435.1 Adult Fat Body    183.1 Adult Salivary Gland    127.2 Adult Heart    214.05 Adult VirginFemale Spermatheca    678.6 Adult InseminatedFemale Spermatheca    589.3 Adult Ovary    81 Adult Testis    73.8 Adult Male Accessory Gland    69.2 Adult Carcass    75.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    311.45 Larval Midgut    173.1 Larval Hindgut    164.8 Larval Malpighian Tubules    131.6 Larval Fat Body    108.1 Larval Salivary Gland    104.3 Larval Trachea    204.925 Larval Carcass    102.45 Adult Head    96.2 Adult Eye    190.85 Adult Brain    114.7 Adult Thoracic-Abdominal Ganglion    89.4 Adult Crop    145.1 Adult Midgut    94.9 Adult Hindgut    113.3 Adult Malpighian Tubules    435.1 Adult Fat Body    183.1 Adult Salivary Gland    127.2 Adult Heart    214.05 Adult VirginFemale Spermatheca  (678.6) Adult InseminatedFemale Spermatheca  (589.3) Adult Ovary    81 Adult Testis    73.8 Adult Male Accessory Gland    69.2 Adult Carcass    75.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    311.45 Larval Midgut    173.1 Larval Hindgut    164.8 Larval Malpighian Tubules    131.6 Larval Fat Body    108.1 Larval Salivary Gland    104.3 Larval Trachea    204.925 Larval Carcass    102.45 Adult Head    96.2 Adult Eye    190.85 Adult Brain    114.7 Adult Thoracic-Abdominal Ganglion    89.4 Adult Crop    145.1 Adult Midgut    94.9 Adult Hindgut    113.3 Adult Malpighian Tubules    435.1 Adult Fat Body    183.1 Adult Salivary Gland    127.2 Adult Heart    214.05 Adult VirginFemale Spermatheca    678.6 Adult InseminatedFemale Spermatheca    589.3 Adult Ovary    81 Adult Testis    73.8 Adult Male Accessory Gland    69.2 Adult Carcass    75.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    311.45 Larval Midgut    173.1 Larval Hindgut    164.8 Larval Malpighian Tubules    131.6 Larval Fat Body    108.1 Larval Salivary Gland    104.3 Larval Trachea    204.925 Larval Carcass    102.45 Adult Head    96.2 Adult Eye    190.85 Adult Brain    114.7 Adult Thoracic-Abdominal Ganglion    89.4 Adult Crop    145.1 Adult Midgut    94.9 Adult Hindgut    113.3 Adult Malpighian Tubules    435.1 Adult Fat Body    183.1 Adult Salivary Gland    127.2 Adult Heart    214.05 Adult VirginFemale Spermatheca    678.6 Adult InseminatedFemale Spermatheca    589.3 Adult Ovary    81 Adult Testis    73.8 Adult Male Accessory Gland    69.2 Adult Carcass    75.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0025800 expression level Tissue   Expression Level Larval Central Nervous System    311.45 Larval Midgut    173.1 Larval Hindgut    164.8 Larval Malpighian Tubules    131.6 Larval Fat Body    108.1 Larval Salivary Gland    104.3 Larval Trachea    204.925 Larval Carcass    102.45 Adult Head    96.2 Adult Eye    190.85 Adult Brain    114.7 Adult Thoracic-Abdominal Ganglion    89.4 Adult Crop    145.1 Adult Midgut    94.9 Adult Hindgut    113.3 Adult Malpighian Tubules    435.1 Adult Fat Body    183.1 Adult Salivary Gland    127.2 Adult Heart    214.05 Adult VirginFemale Spermatheca    678.6 Adult InseminatedFemale Spermatheca    589.3 Adult Ovary    81 Adult Testis    73.8 Adult Male Accessory Gland    69.2 Adult Carcass    75.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    311.45 Larval Midgut    173.1 Larval Hindgut    164.8 Larval Malpighian Tubules    131.6 Larval Fat Body    108.1 Larval Salivary Gland    104.3 Larval Trachea    204.925 Larval Carcass    102.45 Adult Head    96.2 Adult Eye    190.85 Adult Brain    114.7 Adult Thoracic-Abdominal Ganglion    89.4 Adult Crop    145.1 Adult Midgut    94.9 Adult Hindgut    113.3 Adult Malpighian Tubules    435.1 Adult Fat Body    183.1 Adult Salivary Gland    127.2 Adult Heart    214.05 Adult VirginFemale Spermatheca  678.6 Adult InseminatedFemale Spermatheca  589.3 Adult Ovary    81 Adult Testis    73.8 Adult Male Accessory Gland    69.2 Adult Carcass    75.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    311.45 Larval Midgut    173.1 Larval Hindgut    164.8 Larval Malpighian Tubules    131.6 Larval Fat Body    108.1 Larval Salivary Gland    104.3 Larval Trachea    204.925 Larval Carcass    102.45 Adult Head    96.2 Adult Eye    190.85 Adult Brain    114.7 Adult Thoracic-Abdominal Ganglion    89.4 Adult Crop    145.1 Adult Midgut    94.9 Adult Hindgut    113.3 Adult Malpighian Tubules    435.1 Adult Fat Body    183.1 Adult Salivary Gland    127.2 Adult Heart    214.05 Adult VirginFemale Spermatheca    678.6 Adult InseminatedFemale Spermatheca    589.3 Adult Ovary    81 Adult Testis    73.8 Adult Male Accessory Gland    69.2 Adult Carcass    75.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    311.45 Larval Midgut    173.1 Larval Hindgut    164.8 Larval Malpighian Tubules    131.6 Larval Fat Body    108.1 Larval Salivary Gland    104.3 Larval Trachea    204.925 Larval Carcass    102.45 Adult Head    96.2 Adult Eye    190.85 Adult Brain    114.7 Adult Thoracic-Abdominal Ganglion    89.4 Adult Crop    145.1 Adult Midgut    94.9 Adult Hindgut    113.3 Adult Malpighian Tubules    435.1 Adult Fat Body    183.1 Adult Salivary Gland    127.2 Adult Heart    214.05 Adult VirginFemale Spermatheca    678.6 Adult InseminatedFemale Spermatheca    589.3 Adult Ovary    81 Adult Testis    73.8 Adult Male Accessory Gland    69.2 Adult Carcass    75.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    96.2   NA  Eye    190.85   NA  Brain    114.7   311.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    89.4   NA  Crop    145.1   173.1  Midgut    94.9   164.8  Hindgut    113.3   131.6  Malpighian Tubules    435.1   108.1  Fat Body    183.1   104.3  Salivary Gland    127.2   NA  Heart    214.05   204.925  Trachea    NA   NA  VirginFemale Spermatheca    678.6   NA  InseminatedFemale Spermatheca    589.3   NA  Ovary    81   NA  Testis    73.8   NA  Male Accessory Gland    69.2   102.45  Carcass    75.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025800 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2262-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pharate adult stage SmoxG0348 lethal | pupal stage, with Scer\GAL4pnr-MD237 SmoxGD6452 semi-lethal | recessive SmoxG0348 Other Phenotypes Allele cell growth defective, with Scer\GAL4A9 SmoxScer\UAS.cGa SmoxSDVD.Scer\UAS mitotic cell cycle defective SmoxMB388 neuroanatomy defective SmoxMB388 neuroanatomy defective | embryonic stage SmoxMB388 neuroanatomy defective | embryonic stage | germline clone Smoxunspecified neuroanatomy defective | somatic clone Smox1 visible, with Scer\GAL4A9 SmoxScer\UAS.cZa Phenotype manifest in Allele abdominal segmental nerve | germline clone Smoxunspecified axon & eye photoreceptor cell SmoxMB388 chaeta SmoxG0348 distal medulla glial cell SmoxMB388 dorsal cluster neuron & axon | somatic clone Smox1 dorsal cluster neuron & neurite | somatic clone Smox1 fascicle | somatic clone Smox1 gamma-lobe & dendrite | somatic clone SmoxMB388 gamma-lobe & neuron | somatic clone SmoxMB388 lamina SmoxMB388 lamina anlage glial cell SmoxMB388 larval inner optic anlage SmoxMB388 larval outer optic anlage SmoxMB388 medulla neuropil SmoxMB388 optic lobe | somatic clone Smox1 photoreceptor cell R7 & axon SmoxMB388 photoreceptor cell R7 | somatic clone Smox1 photoreceptor cell R8 & axon SmoxMB388 protocerebrum | somatic clone Smox1 wing SmoxG0348 wing, with Scer\GAL4A9 SmoxScer\UAS.cZa SmoxScer\UAS.cGa SmoxSDVD.Scer\UAS wing, with Scer\GAL4nub-AC-62 SmoxScer\UAS.cZa
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of Smox Class Mutagen Stocks Known lesion SmoxG0348 P-element activity 1 -- Smox1 0 -- Smoxdon 0 -- SmoxEP1371 P-element activity 0 -- SmoxGG01120 0 -- SmoxMB388 ethyl methanesulfonate 0 Yes Smoxunspecified 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Smox Class Mutagen Stocks Known lesion SmoxGD6452 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SmoxJF02320 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SmoxKK111163 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SmoxAct5C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SmoxScer\UAS.cGa 0 Yes SmoxScer\UAS.cZa in vitro construct - regulatory fusion 0 Yes SmoxScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SmoxScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SmoxSDVD.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)hl-a (Zheng et al., 2003) Df(1)RA2 (Zheng et al., 2003)
Not disrupted in	Df(1)C128 (Zheng et al., 2003) Df(1)Desi-S3 (Zheng et al., 2003) Df(1)GE202 (Zheng et al., 2003)
Duplicated in	Dp(1;3)DC185 (Popodi et al., 2010-) Dp(1;3)DC186 (Popodi et al., 2010-)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6452} NA P{KK111163} NA P{TRiP.JF02320} NA P{UAS-dSMAD2.G} NA P{UAS-dSmad2.Z} NA P{UAS-FLAG-Smox} NA P{UAS-SMAD2.SDVD} NA P{UAS-Smox.Myc} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}SmoxEP1371 NA P{Mae-UAS.6.11}SmoxGG01120 NA insertion of enhancer trap P{lacW}SmoxG0348 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with vis (Hyman et al., 2003)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Parker et al., 2006) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Marquez et al., 2001) mushroom body development inferred from mutant phenotype (Zheng et al., 2003) neuron development inferred from mutant phenotype (Zheng et al., 2006) regulation of mitotic cell cycle inferred from mutant phenotype (Zhu et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from electronic annotation with InterPro:IPR013019 (FlyBase Curators et al., 2004-) transforming growth factor beta receptor, cytoplasmic mediator activity inferred from sequence or structural similarity with EMBL:AF016189 (FlyBase, 1992-)
Biological Process
CV term Evidence References
dendrite morphogenesis non-traceable author statement (Grueber and Jan, 2004) regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR001132, InterPro:IPR003619, InterPro:IPR013019, InterPro:IPR013790 (FlyBase Curators et al., 2004-) transforming growth factor beta receptor signaling pathway inferred from electronic annotation with InterPro:IPR013019 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
transcription factor complex inferred from electronic annotation with InterPro:IPR013019 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Smox allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58206 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025800 DroID - A comprehensive database of gene and protein interactions. • FBgn0025800 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31738
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20979 Dere\GG17985 Dgri\GH24864 Dmoj\GI14415 Dper\GL20193 Dpse\GA15332 Dsec\GM11208 Dsim\GD24642 Dvir\GJ18762 Dwil\GK24988 Dyak\GE17479
Curated drosophilid orthologs	Dpse\GA15332
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008696-PA Aedes aegypti (mosquito) AGAP009777-PA Anopheles gambiae (mosquito) XP_396056.3 Apis mellifera (honey bee) 278811 Branchiostoma floridae (lancelet) BGIBMGA009650-PA Bombyx mori (silk worm) ENSBTAP00000016728 Bos taurus (bovine) ENSCAFP00000025899 Canis familiaris (dog) CPIJ004833 Culex pipens (mosquito) ENSCPOP00000017459 Cavia porcellus (guinea pig) ENSCSAVP00000007961 Ciona savignyi (sedentary tunicate) 167863 Capitella spl (polychaete worm) ENSDARP00000045373 Danio rerio (zebra fish) ENSECAP00000013038 Equus caballus (horse) ENSGACP00000006754 Gymnopilus aculeatus (mushroom) ENSGALP00000012766 Gallus gallus (chicken) 185435 Hypsipyla robusta (cedar shoot borer) ENSP00000332973 Homo sapiens (human) ENSMODP00000012005 Monodelphis domestica (gray opossum) ENSMMUP00000020271 Macaca mulatta (rhesus monkey) ENSMUSP00000109564 Mus musculus (house mouse) 168041 Nematostella vectensis (starlet anemone) XP_001608214.1 Nasonia vitripennis (wasp) ENSOANP00000003129 Ornithorynchus anatinus (platypus) ENSORLP00000019643 Oryzias latipes (japanese killifish) PHUM000549-PA Pediculus humanus (human body louse) PP02689 Pristionchus pacificus (nematode) ENSPPYP00000007465 Pongo pygmaeus (orangutan) ENSPTRP00000012319 Pan troglodytes (chimpanzee) ENSRNOP00000037346 Rattus norvegicus (norway rat) Smp_085910 Schistosoma mansoni (trematode parasite) XP_001177926.1 Strongylocentrotus purpuratus (purple sea urchin) 49742 Trichoplax adhaerens (metazoa) ENSTNIP00000012419 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037811 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000043789 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15991 NV10880 LH11668 FBgn0234944 FBgn0226947 FBgn0205914 FBgn0195970 FBgn0166153 JGI_V11_314805 FBgn0075352 FBgn0157788 FBgn0137167 FBgn0132319 FBgn0110203 FBgn0097984 CPIJ004833 CPIJ018355 BGIBMGA009650 ACYPI005545 GB19607 AGAP009777 AAEL008696 PHUM033930 GLEAN_10162
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	12246 w67c23 P{lacW}SmoxG0348/FM7c 26756 y1 v1; P{TRiP.JF02320}attP2/TM3, Sb1
VDRC	v105687 P{KK111163}VIE-260B v14609 w1118; P{GD6452}v14609
Genomic Clones ( 1 )
	BACR39F18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 64 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD15813 RE53485
Other clones	DPiM_LD15813
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT06633 HL01577 LP20855 RE01530 RE12035 RE16142 RE21203 RE56118 RE57917 RH14979 RH44110 RH54436 RH56177
Other clones	39979 60858 75248 76014 78059 102143 105307 149200 153384 180712 214381.23 569087 CK01.30D.B4 CK01.62C.F9 CK01.142D.D1 CK01.147C.C8 CK01.170A.C3 CK01082 Dmel_dig_007040_0701_2333 Dmel_neb_014017_0385_1458 Dmel_neb_014618_0096_1150 EC054292 EC056246 EK049719 EK049722 EK050521 EK053519 EK053522 EK059707 EK059710 EK104210 EK116013 EK120844 EK154238 EK174416 EK186920 EK207227 EK225310 EK230653 EK257060 EK285923 EN14522 EP10861 FGM104H10 RC0-DP0003-150700-022-G02 RC0-DP0003-150700-022-H01 RE01531 RH09338
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025800 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31738
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Smox CG2262 (Zhang, 1999.11)
Source for database merge of	Source for merge of: Smox Sad (Gelbart, 2000.4.17) Source for merge of: Smox tmp (Padgett, 2000.8.24)
Additional comments
Other Comments
	Smox is required during the late larval stage for development of adult-specific neurons. (Zheng et al., 2006) babo/Smox mediated TGFΒ/Activin signalling mediates remodeling of mushroom body neurons via controlling EcR-B1 expression. (Zheng et al., 2003) Overexpression of Med, Smox, Hsap\MADH2 or Hsap\MADH4 causes a similar phenotype in the wing. (Marquez et al., 2001) Smox is highly expressed in tissues that require babo function and can be phosphorylated by overexpression of activated babo or wild type babo and put together. (Brummel et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078524 RefSeq (Proteins) • NP_511079 DDBJ / EMBL / GenBank • AA141008 AA141009 AAC83344 AAD11458 AAD22443 AAF46330 AAO45214 AAV36990 AF078529 AF101386 AF109132 AJ426765 AQ073211 BI367685 BT004858 BT016105 Entrez Gene - A searchable database of RefSeq genes. • 31738 UniProtKB/TrEMBL • O96660 Q9TZQ2 Q86NL2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SMAD domain, Dwarfin-type (IPR001132) MAD homology 1, Dwarfin-type (IPR003619) SMAD/FHA domain (IPR008984) MAD homology, MH1 (IPR013019) Dwarfin (IPR013790) SMAD domain-like (IPR017855)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58206 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025800 DroID - A comprehensive database of gene and protein interactions. • FBgn0025800 DRSC - Results from RNAi screens. • FBgn0025800 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025800 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2262-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025800 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31738 InParanoid A subset of ortholog calls from InParanoid. • AAEL008696-PA Aedes aegypti (mosquito) AGAP009777-PA Anopheles gambiae (mosquito) XP_396056.3 Apis mellifera (honey bee) 278811 Branchiostoma floridae (lancelet) BGIBMGA009650-PA Bombyx mori (silk worm) ENSBTAP00000016728 Bos taurus (bovine) ENSCAFP00000025899 Canis familiaris (dog) CPIJ004833 Culex pipens (mosquito) ENSCPOP00000017459 Cavia porcellus (guinea pig) ENSCSAVP00000007961 Ciona savignyi (sedentary tunicate) 167863 Capitella spl (polychaete worm) ENSDARP00000045373 Danio rerio (zebra fish) ENSECAP00000013038 Equus caballus (horse) ENSGACP00000006754 Gymnopilus aculeatus (mushroom) ENSGALP00000012766 Gallus gallus (chicken) 185435 Hypsipyla robusta (cedar shoot borer) ENSP00000332973 Homo sapiens (human) ENSMODP00000012005 Monodelphis domestica (gray opossum) ENSMMUP00000020271 Macaca mulatta (rhesus monkey) ENSMUSP00000109564 Mus musculus (house mouse) 168041 Nematostella vectensis (starlet anemone) XP_001608214.1 Nasonia vitripennis (wasp) ENSOANP00000003129 Ornithorynchus anatinus (platypus) ENSORLP00000019643 Oryzias latipes (japanese killifish) PHUM000549-PA Pediculus humanus (human body louse) PP02689 Pristionchus pacificus (nematode) ENSPPYP00000007465 Pongo pygmaeus (orangutan) ENSPTRP00000012319 Pan troglodytes (chimpanzee) ENSRNOP00000037346 Rattus norvegicus (norway rat) Smp_085910 Schistosoma mansoni (trematode parasite) XP_001177926.1 Strongylocentrotus purpuratus (purple sea urchin) 49742 Trichoplax adhaerens (metazoa) ENSTNIP00000012419 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037811 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000043789 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /torstoll/smadox1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31738 modMine - Data generated by the modENCODE project. • FBgn0025800 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15991 NV10880 LH11668 FBgn0234944 FBgn0226947 FBgn0205914 FBgn0195970 FBgn0166153 JGI_V11_314805 FBgn0075352 FBgn0157788 FBgn0137167 FBgn0132319 FBgn0110203 FBgn0097984 CPIJ004833 CPIJ018355 BGIBMGA009650 ACYPI005545 GB19607 AGAP009777 AAEL008696 PHUM033930 GLEAN_10162
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	CG2262 (Perkins et al., 2009.3.31, Keleman et al., 2009.8.5) dSmad2 (Zheng et al., 2006, Massague, 2005, Lee-Hoeflich et al., 2005, Grueber and Jan, 2004, Funakoshi et al., 2004, Liang et al., 2003, Zheng et al., 2003, Zheng et al., 2003, Parker and Arora, 2002, Padgett et al., 2002, Stefancsik et al., 2001, Marquez et al., 2001, Padgett et al., 2001, Stefancsik et al., 2001, Zimmerman and Padgett, 2000, Nakayama et al., 2000, Attisano and Wrana, 2000, Massague and Wotton, 2000, Das et al., 2000, Newfeld et al., 2000, Zhang and Derynck, 1999, Raftery and Sutherland, 1999, Das et al., 1999, Das et al., 1999, Brummel et al., 1999, Zhu et al., 2006, Newfeld et al., 2007, Takaesu et al., 2006, Hyman et al., 2003, Marques, 2005, Batut et al., 2008, Ng, 2008, Barrio et al., 2007, Pinto et al., 2008, Koh et al., 2004, Ting et al., 2007, Ellis et al., 2010, Sander et al., 2010) dSMAD2 (Massague, 2000, Pinto et al., 2006, Bickel et al., 2008, Gesualdi and Haerry, 2007) DSMAD2 (Tanimoto et al., 2000) DSmad2 (Pistillo and Desplan, 2007, Pistillo et al., 2007) dsmad2 (Ting et al., 2007) l(1)G0348 (Schaefer et al., 1999.12.2, ) Sad (Andrew, 1998.3.10, ) sad (Henderson and Andrew, 1998) SMAD2 (Sanyal et al., 2004) smad2 (Brummel, 1998.10.26) Smad2 (Padgett, 1999, Parker et al., 2006, Serpe and O'Connor, 2006, Arora et al., 2008, Zhu et al., 2008, Yang et al., 2004) smox (Stronach and Perrimon, 2002) Smox (Dudu, 2006, Blanco et al., 2010, Nedelsky et al., 2010, Batut et al., 2008, Li et al., 2007, Jensen et al., 2009, Popodi et al., 2010-, Yatsu et al., 2008, Beltran et al., 2007, Goldstein et al., 2011) SMOX (Taylor-Harding et al., 2004) ted (Padgett et al., 1998) tmp
Name Synonym	sisters against dpp (Henderson and Andrew, 1998) Sisters against dpp   Smad on X (Henderson and Andrew, 1998) Smox/dSmad2 (Li et al., 2007) temporarily deranged (Padgett et al., 1998)
Secondary FlyBase IDs
	FBgn0024186 FBgn0024304 FBgn0040171
References ( 95 )
Generate a list of	All references relating to this gene ( 95 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 5 ) Review  ( 12 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 21 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Curated genome annotation  ( 2 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Conference report  ( 1 )
Recent research papers ( 6 )
	Gibbens et al., 2011, Development 138(13): 2693--2703 Neuroendocrine regulation of Drosophila metamorphosis requires TGF{beta}/Activin signaling. [FBrf0213899] Goldstein et al., 2011, Hum. Mol. Genet. 20(5): 894--904 SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy. [FBrf0212934] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Ellis et al., 2010, Dev. Biol. 342(2): 121--133 Activin signaling functions upstream of Gbb to regulate synaptic growth at the Drosophila neuromuscular junction. [FBrf0210828] Nedelsky et al., 2010, Neuron 67(6): 936--952 Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy. [FBrf0211903] Sander et al., 2010, PLoS ONE 5(4): e10383 Drosophila Smad2 opposes mad signaling during wing vein development. [FBrf0210719] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...