FlyBase Gene Report: Dmel\Sbf

General Information

Symbol

Dmel\Sbf

Species

D. melanogaster

Name

SET domain binding factor

Annotation Symbol

CG6939

Feature Type

protein_coding_gene

FlyBase ID

FBgn0025802

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Sbf1

Key Links

Genomic Location

Cytogenetic map

86F8-86F8

Sequence location

3R:11,789,293..11,796,948 [-]

Recombination map

3-51

RefSeq locus

NT_033777 REGION:11789293..11796948

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (22 terms)

Molecular Function (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

enables chromatin binding

inferred from direct assay

(Petruk et al., 2006)

enables guanyl-nucleotide exchange factor activity

inferred from physical interaction with FLYBASE:Rab21; FB:FBgn0039966

(Jean et al., 2012)

enables phosphatase binding

inferred from physical interaction with FLYBASE:mtm; FB:FBgn0025742

(Jean et al., 2012)

enables phosphatidylinositol 3-kinase catalytic subunit binding

inferred from physical interaction with FLYBASE:Pi3K68D; FB:FBgn0015278

(Jean et al., 2012)

enables protein-macromolecule adaptor activity

inferred from physical interaction with FLYBASE:Pi3K68D; FB:FBgn0015278, FLYBASE:mtm; FB:FBgn0025742, FLYBASE:Rab21; FB:FBgn0039966

(Jean et al., 2012)

enables small GTPase binding

inferred from physical interaction with FLYBASE:Rab11; FB:FBgn0015790, FLYBASE:Rab21; FB:FBgn0039966

(Jean et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables guanyl-nucleotide exchange factor activity

inferred from sequence or structural similarity with HGNC:2135

(Jean et al., 2012)

inferred from biological aspect of ancestor with PANTHER:PTN002474114

(assigned by GO_Central )

(Gaudet et al., 2011)

NOT enables protein tyrosine phosphatase activity

inferred from key residues

(Hatzihristidis et al., 2015)

Biological Process (8 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

involved_in cortical actin cytoskeleton organization

inferred from mutant phenotype

(Jean et al., 2012)

involved_in endocytic recycling

inferred from mutant phenotype

(Jean et al., 2012)

involved_in histone acetylation

inferred from direct assay

(Petruk et al., 2003)

involved_in histone H3-K4 methylation

inferred from direct assay

(Petruk et al., 2003)

involved_in mitotic cell cycle

inferred from mutant phenotype

(Chen et al., 2007)

involved_in positive regulation of autophagosome maturation

inferred from mutant phenotype

(Jean et al., 2015)

involved_in positive regulation of transcription elongation from RNA polymerase II promoter

inferred from direct assay

(Petruk et al., 2006)

inferred from mutant phenotype

(Petruk et al., 2006)

involved_in regulation of Rab protein signal transduction

inferred from direct assay

(Jean et al., 2012)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

located_in cell cortex

inferred from direct assay

(Jean et al., 2012)

part_of histone acetyltransferase complex

inferred from direct assay

(Petruk et al., 2003)

part_of histone methyltransferase complex

inferred from direct assay

(Petruk et al., 2003)

located_in nucleus

inferred from direct assay

(Petruk et al., 2006)

located_in polytene chromosome

inferred from direct assay

(Petruk et al., 2001)

located_in recycling endosome

inferred from direct assay

(Jean et al., 2012)

part_of transcription elongation factor complex

inferred from physical interaction with FLYBASE:trx; FB:FBgn0003862

(Petruk et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

DUAL SPECIFICITY PHOSPHATASES

TRITHORAX ACETYLATION COMPLEX 1

RAB GUANINE NUCLEOTIDE EXCHANGE FACTORS - DENN DOMAIN

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

DUAL SPECIFICITY PHOSPHATASES -: Dual Specificity Phosphatases (DSP) can dephosphorylate both tyrosine and serine/threonine residues. Additionally, DSPs may target a much larger and diverse set of substrates, including phosphoinositide lipids, RNA 5'-triphosphate and carbohydrates. (Adapted from FBrf0227974).
TRITHORAX ACETYLATION COMPLEX 1 -: The Trithorax Acetylation Complex 1 (TAC1) possesses histone H3 K4 methyltransferase and histone acetyltransferase activities. (Adapted from FBrf0192625 and FBrf0167942).
RAB GUANINE NUCLEOTIDE EXCHANGE FACTORS - DENN DOMAIN -: DENN domain-containing proteins are Guanine Nucleotide Exchange Factors (GEFs) for Rab family GTPases. (Adapted from FBrf0220596).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Sbf for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Sbf-RA

FBtr0082529

NM_058053

6782

1993

Sbf-RB

FBtr0082530

NM_169430

6722

1973

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Sbf-PA

FBpp0082003

225.1

1993

7.11

NP_477401

AAF54700

Sbf-PB

FBpp0082004

222.6

1973

7.01

NP_731633

AAN13531

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sbf using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sbf_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cell cortex

inferred from direct assay

(Jean et al., 2012)

part_of histone acetyltransferase complex

inferred from direct assay

(Petruk et al., 2003)

part_of histone methyltransferase complex

inferred from direct assay

(Petruk et al., 2003)

located_in nucleus

inferred from direct assay

(Petruk et al., 2006)

located_in polytene chromosome

inferred from direct assay

(Petruk et al., 2001)

located_in recycling endosome

inferred from direct assay

(Jean et al., 2012)

part_of transcription elongation factor complex

inferred from physical interaction with FLYBASE:trx; FB:FBgn0003862

(Petruk et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sbf in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sbf

View exonic expression by tissue for Dmel\Sbf

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0025802

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6939-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6939

Flygut - An atlas of the Drosophila adult midgut

FBgn0025802

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 15 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sbf

Transgenic constructs containing regulatory region of Sbf

Deletions and Duplications ( 1 )

Disrupted in

Df(3R)Exel7310

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of P-stage, with Scer\GAL4^pnr-MD237

Sbf^GD12081

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sbf^GD12081

viable, with Scer\GAL4^Mef2.PR

Sbf^GD12081

viable, with Scer\GAL4^tin.CΔ4

Sbf^GD12081

Sterility

Allele

female semi-sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

Sbf^HMS00414

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

Sbf^HMS02718

Other Phenotypes

Allele

some die during pharate adult stage, with Scer\GAL4^pnr-MD237

Sbf^GD12081

starvation stress response defective, with Scer\GAL4^Cg.PA

Sbf^HMS00414

Phenotype manifest in

Allele

autolysosome | calorie restriction conditional, with Scer\GAL4^Cg.PA

Sbf^HMS00414

fat body, with Scer\GAL4^Cg.PA

Sbf^HMS00414

macrophage, with Scer\GAL4^Cg.PA

Sbf^UAS.mCherry

macrophage, with Scer\GAL4^Pxn.PS

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SBF1

14 of 15

Yes

Hsap\SBF2

14 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Sbf1

12 of 15

Yes

Mmus\Sbf2

12 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (13)

Rnor\Sbf2

13 of 13

Yes

Rnor\Sbf1

9 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (13)

Xtro\sbf2

9 of 12

Yes

Xtro\sbf1

8 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (15)

Drer\sbf2

14 of 15

Yes

Drer\sbf1

12 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\mtm-5

14 of 15

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\MTM1

1 of 9

Yes

Atha\MTM2

1 of 9

Yes

Atha\SCD1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\YMR1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPAC19A8.03

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919009Y )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19970

Drosophila persimilis

Dper\GL12246

Drosophila willistoni

Dwil\GK14310

Drosophila virilis

Dvir\GJ10154

Drosophila mojavensis

Dmoj\GI10301

Drosophila grimshawi

Dgri\GH23138

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150072 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17005628

Glossina morsitans

Tsetse fly

Gmor\GMOY009980

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13044

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01993

Mayetiola destructor

Hessian fly

Mdes\Mdes006348

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL006022

Anopheles darlingi

American malaria mosquito

Adar\ADAC009621

Anopheles gambiae

Malaria mosquito

Agam\AGAP003366

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ002034

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W005L )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA009224

Bombyx mori

Silkmoth

Bmor\BGIBMGA009225

Danaus plexippus

Monarch butterfly

Dple\DPOGS216107-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS216106-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS216108-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL015447

Heliconius melpomene

Postman butterfly

Hmel\HMEL004857

Apis florea

Little honeybee

Aflo\2528192244

Apis mellifera

Western honey bee

Amel\Sbf

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP16072

Bombus terrestris

Buff-tailed bumblebee

Bter\15214644

Linepithema humile

Argentine ant

Lhum\LH13041

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000810

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG004378

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09470

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09469

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_07785

Pediculus humanus

Human body louse

Phum\PHUM006440

Rhodnius prolixus

Kissing bug

Rpro\RPRC003347

Cimex lectularius

Bed bug

Clec\CLEC008735

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI068502

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_14426

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X005F )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR011997

Ixodes scapularis

Black-legged tick

Isca\ISCW017609

Stegodyphus mimosarum

African social velvet spider

Smim\KFM81050.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM81049.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur23g00530

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_303150

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00CQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Sbf2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Sbf1L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mtmr5/13

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000019580

Gallus gallus

Domestic chicken

Ggal\SBF1

Gallus gallus

Domestic chicken

Ggal\SBF2

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (5)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

mtm

2 of 10

Mtmr6

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

SBF2; SET binding factor 2

model of Charcot-Marie-Tooth disease type 4B2

IEA

(FlyBase, 2019-)

SBF1; SET binding factor 1

model of Charcot-Marie-Tooth disease type 4B3

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SBF1; SET binding factor 1

14 of 15

603560

CHARCOT-MARIE-TOOTH DISEASE, TYPE 4B3; CMT4B3

Charcot-Marie-Tooth disease type 4B3

SBF2; SET binding factor 2

14 of 15

607697

CHARCOT-MARIE-TOOTH DISEASE, TYPE 4B2; CMT4B2

Charcot-Marie-Tooth disease type 4B2

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Sbf - Pi3K68D

anti bait coimmunoprecipitation, western blot, anti tag western blot

(Jean et al., 2012)

Sbf - Rab11

anti tag coimmunoprecipitation, anti tag western blot

(Jean et al., 2012)

Sbf - Rab21

anti tag coimmunoprecipitation, anti tag western blot, gtpase assay, pull down, autoradiography, anti bait coimmunoprecipitation, western blot

(Jean et al., 2015, Jean et al., 2012)

Sbf - Rab35

pull down, western blot, peptide massfingerprinting

(Miao et al., 2019, Gillingham et al., 2014)

Sbf - Vamp7

anti bait coimmunoprecipitation, anti tag western blot

(Jean et al., 2015)

Sbf - mtm

anti bait coimmunoprecipitation, anti tag western blot

(Jean et al., 2012)

Sbf - nej

ion exchange chromatography, molecular sieving, peptide massfingerprinting, western blot

(Petruk et al., 2001)

Sbf - ph-p

anti tag coimmunoprecipitation, peptide massfingerprinting

(Saurin et al., 2001)

Sbf - trx

ion exchange chromatography, molecular sieving, peptide massfingerprinting, western blot

(Petruk et al., 2001)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Sbf

suppressible

mtm

(Jean et al., 2012)

Sbf

suppressible

Pi3K68D

(Jean et al., 2012)

Sbf

suppressible

Rab21

(Jean et al., 2012)

Sbf

suppressible

Rac1

(Jean et al., 2012)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

mtm

suppressible

Sbf

(Jean et al., 2012)

Rab21

suppressible

Sbf

(Jean et al., 2012)

Rab21

enhanceable

Sbf

(Jean et al., 2012)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0025802

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

41427

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-51

Cytogenetic map

86F8-86F8

Sequence location

3R:11,789,293..11,796,948 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

86F8-86F8

Limits computationally determined from genome sequence between P{EP}Lk6^EP886 and P{PZ}svp⁰⁷⁸⁴²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

86F-86F

(Li, 1998.9.22)

86F-86F

(determined by in situ hybridisation)

(Bryant et al., 1999)

Experimentally Determined Recombination Data

Location

3-51

(FlyBase, 2016)

3-48.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Bloomington

44004

y¹ v¹; P{TRiP.HMS02718}attP40

76115

y¹ sc^* v¹ sev²¹; P{TOE.GS01026}attP40

76979

y¹ sc^* v¹ sev²¹; P{TKO.GS00729}attP40

32419

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00414}attP2

57301

y¹ sc^* v¹ sev²¹; P{TRiP.HMS04499}attP40

VDRC

v330252

P{VSH330252}attP40

v22317

w¹¹¹⁸; P{GD12081}v22317

v342184

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01746}attP40/CyO-GFP

v342366

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02222}attP40/CyO-GFP

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (12)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD10541

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0025802

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0025802

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41427

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Jean et al., 2012, Petruk et al., 2001)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Other Comments

dsRNA made from templates generated with primers directed against Sbf that is transfected into S2 treated with Listeria monocytogenes reveals Sbf to be involved in Listeria monocytogenes entry, intracellular growth, and vacuolar escape. Treatment with Sbf dsRNA leads to an approximate 50% decrease in bacterial entry, and an approximate 35% decrease in vacuolar escape.

(Cheng et al., 2005)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 50 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41427

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0025802

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sbf_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6939

Flygut - An atlas of the Drosophila adult midgut

FBgn0025802

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41427

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007785

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG6939

modMine - A data warehouse for the modENCODE project

FBgn0025802

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0025802

DRSC - Results frm RNAi screens

FBgn0025802

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0025802

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6939-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0025802

FlyMine - An integrated database for Drosophila genomics

FBgn0025802

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

41427

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG6939

(Allen et al., 2020, Yamaguchi and Takashima, 2018, Meadows, 2017.1.11, Chen et al., 2012, Christis and Munro, 2012, Ni et al., 2010.12.1, Jiang et al., 2008, Robinson and Dixon, 2006, Mount, 2001.8.14)

DSbf1

(Bryant et al., 1999)

MTMR5/13

(Robinson and Dixon, 2006)

SBF

(Levivier et al., 2001, Doerks et al., 2000)

SBF1

(Schuettengruber et al., 2011)

Sbf

(Allen et al., 2020, Kitani-Morii and Noto, 2020, Miao et al., 2019, Yamaguchi and Takashima, 2018, Bussmann and Storkebaum, 2017, Transgenic RNAi Project members, 2017-, Brewer-Jensen et al., 2016, Hatzihristidis et al., 2015, Jean et al., 2015, Luck et al., 2014, Sopko et al., 2014, Jean et al., 2012, Zhou et al., 2008)

Sbf1

(Yoshimura et al., 2010, Schuettengruber et al., 2007, Petruk et al., 2006, Sanchez-Elsner and Sauer, 2004, Smith et al., 2004, Petruk et al., 2003, Petruk et al., 2001)

dSbf1

(Saurin et al., 2001)

sbf

(Follmer et al., 2012, Chen et al., 2007, Cheng et al., 2005, Li, 1998.9.22)

Name Synonyms

SET domain binding factor

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (61)

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