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Gene Dmel\Rad17

General Information
Symbol	Dmel\Rad17	Species	D. melanogaster
Name	Rad17	Annotation symbol	CG7825
Feature type	protein_coding_gene	FlyBase ID	FBgn0025808
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88C10-88C10	Sequence location	3R:10,486,898..10,488,914 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rad17 is referred to in FlyBase by the symbol Dmel\Rad17 (CG7825, FBgn0025808). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. Based on sequence similarity, it is predicted to be involved in the biological process: DNA repair. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Checkpoint protein Rad24. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1626520_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Rad17. Gene sequence location is 3R:10486898..10488914.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN21096 HFA16811
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88C10-88C10   Limits computationally determined from genome sequence between P{PZ}put10460 and P{EP}CG33967EP666
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rad17 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rad17-RA FBtr0082974  NM_142125   1818   535
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rad17-PA   FBpp0082433   59.4   535   8.61     NP_650382   AAF55086
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Checkpoint protein Rad24 (IPR004582)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA539148   AA820062   AA949191   AE014297 AAF55086   AF076839 AAC95521   AF124503 AAD31692   AI516622   AY071291 AAL48913   BI172428   BI235878   BT056240   CO307256   EC077523   EV598544
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O96532 Q7KND1 Q8SYV6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0025808    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0025808 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0025808 expression level Developmental Stage   Expression Level embryo 00-02hr    1708 embryo 02-04hr    1080 embryo 04-06hr    555 embryo 06-08hr    525 embryo 08-10hr    583 embryo 10-12hr    393 embryo 12-14hr    443 embryo 14-16hr    224 embryo 16-18hr    186 embryo 18-20hr    154 embryo 20-22hr    120 embryo 22-24hr    164 larva L1    134 larva L2    141 larva L3 12hr old    106 larva L3 puffstage 1-2    152 larva L3 puffstage 3-6    224 larva L3 puffstage 7-9    368 white prepupae new    355 white prepupae 12hr    362 white prepupae 24hr    440 pupae 2d postWPP    342 pupae 3d postWPP    219 pupae 4d postWPP    123 adult male 01day    155 adult male 05day    199 adult male 30day    162 adult female 01day    377 adult female 05day    988 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1708) embryo 02-04hr  (1080) embryo 04-06hr  (555) embryo 06-08hr  (525) embryo 08-10hr  (583) embryo 10-12hr  (393) embryo 12-14hr  (443) embryo 14-16hr  (224) embryo 16-18hr  (186) embryo 18-20hr  (154) embryo 20-22hr  (120) embryo 22-24hr  (164) larva L1  (134) larva L2  (141) larva L3 12hr old  106 larva L3 puffstage 1-2  (152) larva L3 puffstage 3-6  (224) larva L3 puffstage 7-9  (368) white prepupae new  (355) white prepupae 12hr  (362) white prepupae 24hr  (440) pupae 2d postWPP  (342) pupae 3d postWPP  (219) pupae 4d postWPP  (123) adult male 01day  (155) adult male 05day  (199) adult male 30day  (162) adult female 01day  (377) adult female 05day  (988) adult female 30day  (967) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1708) embryo 02-04hr    1080 embryo 04-06hr    555 embryo 06-08hr    525 embryo 08-10hr    583 embryo 10-12hr    393 embryo 12-14hr    443 embryo 14-16hr    224 embryo 16-18hr    186 embryo 18-20hr    154 embryo 20-22hr    120 embryo 22-24hr    164 larva L1    134 larva L2    141 larva L3 12hr old    106 larva L3 puffstage 1-2    152 larva L3 puffstage 3-6    224 larva L3 puffstage 7-9    368 white prepupae new    355 white prepupae 12hr    362 white prepupae 24hr    440 pupae 2d postWPP    342 pupae 3d postWPP    219 pupae 4d postWPP    123 adult male 01day    155 adult male 05day    199 adult male 30day    162 adult female 01day    377 adult female 05day    988 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1708 embryo 02-04hr    1080 embryo 04-06hr    555 embryo 06-08hr    525 embryo 08-10hr    583 embryo 10-12hr    393 embryo 12-14hr    443 embryo 14-16hr    224 embryo 16-18hr    186 embryo 18-20hr    154 embryo 20-22hr    120 embryo 22-24hr    164 larva L1    134 larva L2    141 larva L3 12hr old    106 larva L3 puffstage 1-2    152 larva L3 puffstage 3-6    224 larva L3 puffstage 7-9    368 white prepupae new    355 white prepupae 12hr    362 white prepupae 24hr    440 pupae 2d postWPP    342 pupae 3d postWPP    219 pupae 4d postWPP    123 adult male 01day    155 adult male 05day    199 adult male 30day    162 adult female 01day    377 adult female 05day    988 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1708 embryo 02-04hr    1080 embryo 04-06hr    555 embryo 06-08hr    525 embryo 08-10hr    583 embryo 10-12hr    393 embryo 12-14hr    443 embryo 14-16hr    224 embryo 16-18hr    186 embryo 18-20hr    154 embryo 20-22hr    120 embryo 22-24hr    164 larva L1    134 larva L2    141 larva L3 12hr old    106 larva L3 puffstage 1-2    152 larva L3 puffstage 3-6    224 larva L3 puffstage 7-9    368 white prepupae new    355 white prepupae 12hr    362 white prepupae 24hr    440 pupae 2d postWPP    342 pupae 3d postWPP    219 pupae 4d postWPP    123 adult male 01day    155 adult male 05day    199 adult male 30day    162 adult female 01day    377 adult female 05day    988 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0025808 expression level Developmental Stage   Expression Level embryo 00-02hr    1708 embryo 02-04hr    1080 embryo 04-06hr    555 embryo 06-08hr    525 embryo 08-10hr    583 embryo 10-12hr    393 embryo 12-14hr    443 embryo 14-16hr    224 embryo 16-18hr    186 embryo 18-20hr    154 embryo 20-22hr    120 embryo 22-24hr    164 larva L1    134 larva L2    141 larva L3 12hr old    106 larva L3 puffstage 1-2    152 larva L3 puffstage 3-6    224 larva L3 puffstage 7-9    368 white prepupae new    355 white prepupae 12hr    362 white prepupae 24hr    440 pupae 2d postWPP    342 pupae 3d postWPP    219 pupae 4d postWPP    123 adult male 01day    155 adult male 05day    199 adult male 30day    162 adult female 01day    377 adult female 05day    988 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1708) embryo 02-04hr  (1080) embryo 04-06hr  (555) embryo 06-08hr  (525) embryo 08-10hr  (583) embryo 10-12hr  (393) embryo 12-14hr  (443) embryo 14-16hr  (224) embryo 16-18hr  (186) embryo 18-20hr  (154) embryo 20-22hr  120 embryo 22-24hr  (164) larva L1  134 larva L2  141 larva L3 12hr old  106 larva L3 puffstage 1-2  (152) larva L3 puffstage 3-6  (224) larva L3 puffstage 7-9  (368) white prepupae new  (355) white prepupae 12hr  (362) white prepupae 24hr  (440) pupae 2d postWPP  (342) pupae 3d postWPP  (219) pupae 4d postWPP  123 adult male 01day  (155) adult male 05day  (199) adult male 30day  (162) adult female 01day  (377) adult female 05day  (988) adult female 30day  (967) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1708 embryo 02-04hr    1080 embryo 04-06hr    555 embryo 06-08hr    525 embryo 08-10hr    583 embryo 10-12hr    393 embryo 12-14hr    443 embryo 14-16hr    224 embryo 16-18hr    186 embryo 18-20hr    154 embryo 20-22hr    120 embryo 22-24hr    164 larva L1    134 larva L2    141 larva L3 12hr old    106 larva L3 puffstage 1-2    152 larva L3 puffstage 3-6    224 larva L3 puffstage 7-9    368 white prepupae new    355 white prepupae 12hr    362 white prepupae 24hr    440 pupae 2d postWPP    342 pupae 3d postWPP    219 pupae 4d postWPP    123 adult male 01day    155 adult male 05day    199 adult male 30day    162 adult female 01day    377 adult female 05day    988 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1708 embryo 02-04hr    1080 embryo 04-06hr    555 embryo 06-08hr    525 embryo 08-10hr    583 embryo 10-12hr    393 embryo 12-14hr    443 embryo 14-16hr    224 embryo 16-18hr    186 embryo 18-20hr    154 embryo 20-22hr    120 embryo 22-24hr    164 larva L1    134 larva L2    141 larva L3 12hr old    106 larva L3 puffstage 1-2    152 larva L3 puffstage 3-6    224 larva L3 puffstage 7-9    368 white prepupae new    355 white prepupae 12hr    362 white prepupae 24hr    440 pupae 2d postWPP    342 pupae 3d postWPP    219 pupae 4d postWPP    123 adult male 01day    155 adult male 05day    199 adult male 30day    162 adult female 01day    377 adult female 05day    988 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1708 embryo 02-04hr    1080 embryo 04-06hr    555 embryo 06-08hr    525 embryo 08-10hr    583 embryo 10-12hr    393 embryo 12-14hr    443 embryo 14-16hr    224 embryo 16-18hr    186 embryo 18-20hr    154 embryo 20-22hr    120 embryo 22-24hr    164 larva L1    134 larva L2    141 larva L3 12hr old    106 larva L3 puffstage 1-2    152 larva L3 puffstage 3-6    224 larva L3 puffstage 7-9    368 white prepupae new    355 white prepupae 12hr    362 white prepupae 24hr    440 pupae 2d postWPP    342 pupae 3d postWPP    219 pupae 4d postWPP    123 adult male 01day    155 adult male 05day    199 adult male 30day    162 adult female 01day    377 adult female 05day    988 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0025808    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0025808 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0025808 expression level Tissue   Expression Level Larval Central Nervous System    69.625 Larval Midgut no informative data Larval Hindgut    17 Larval Malpighian Tubules    32.4 Larval Fat Body no informative data Larval Salivary Gland    30.6 Larval Trachea    18.125 Larval Carcass    29.75 Adult Head    19.6 Adult Eye    21.425 Adult Brain    36.3 Adult Thoracic-Abdominal Ganglion    36.7 Adult Crop    22.5 Adult Midgut    18.7 Adult Hindgut    19.9 Adult Malpighian Tubules    28.5 Adult Fat Body no informative data Adult Salivary Gland    42.6 Adult Heart    13.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    168.7 Adult Testis    32.7 Adult Male Accessory Gland    40.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    69.625 Larval Midgut no informative data Larval Hindgut    17 Larval Malpighian Tubules    32.4 Larval Fat Body no informative data Larval Salivary Gland    30.6 Larval Trachea    18.125 Larval Carcass    29.75 Adult Head    19.6 Adult Eye    21.425 Adult Brain    36.3 Adult Thoracic-Abdominal Ganglion    36.7 Adult Crop    22.5 Adult Midgut    18.7 Adult Hindgut    19.9 Adult Malpighian Tubules    28.5 Adult Fat Body no informative data Adult Salivary Gland    42.6 Adult Heart    13.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    168.7 Adult Testis    32.7 Adult Male Accessory Gland    40.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    69.625 Larval Midgut no informative data Larval Hindgut    17 Larval Malpighian Tubules    32.4 Larval Fat Body no informative data Larval Salivary Gland    30.6 Larval Trachea    18.125 Larval Carcass    29.75 Adult Head    19.6 Adult Eye    21.425 Adult Brain    36.3 Adult Thoracic-Abdominal Ganglion    36.7 Adult Crop    22.5 Adult Midgut    18.7 Adult Hindgut    19.9 Adult Malpighian Tubules    28.5 Adult Fat Body no informative data Adult Salivary Gland    42.6 Adult Heart    13.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    168.7 Adult Testis    32.7 Adult Male Accessory Gland    40.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    69.625 Larval Midgut no informative data Larval Hindgut    17 Larval Malpighian Tubules    32.4 Larval Fat Body no informative data Larval Salivary Gland    30.6 Larval Trachea    18.125 Larval Carcass    29.75 Adult Head    19.6 Adult Eye    21.425 Adult Brain    36.3 Adult Thoracic-Abdominal Ganglion    36.7 Adult Crop    22.5 Adult Midgut    18.7 Adult Hindgut    19.9 Adult Malpighian Tubules    28.5 Adult Fat Body no informative data Adult Salivary Gland    42.6 Adult Heart    13.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    168.7 Adult Testis    32.7 Adult Male Accessory Gland    40.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0025808 expression level Tissue   Expression Level Larval Central Nervous System    69.625 Larval Midgut no informative data Larval Hindgut    17 Larval Malpighian Tubules    32.4 Larval Fat Body no informative data Larval Salivary Gland    30.6 Larval Trachea    18.125 Larval Carcass    29.75 Adult Head    19.6 Adult Eye    21.425 Adult Brain    36.3 Adult Thoracic-Abdominal Ganglion    36.7 Adult Crop    22.5 Adult Midgut    18.7 Adult Hindgut    19.9 Adult Malpighian Tubules    28.5 Adult Fat Body no informative data Adult Salivary Gland    42.6 Adult Heart    13.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    168.7 Adult Testis    32.7 Adult Male Accessory Gland    40.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    69.625 Larval Midgut no informative data Larval Hindgut    17 Larval Malpighian Tubules    32.4 Larval Fat Body no informative data Larval Salivary Gland    30.6 Larval Trachea    18.125 Larval Carcass    29.75 Adult Head    19.6 Adult Eye    21.425 Adult Brain    36.3 Adult Thoracic-Abdominal Ganglion    36.7 Adult Crop    22.5 Adult Midgut    18.7 Adult Hindgut    19.9 Adult Malpighian Tubules    28.5 Adult Fat Body no informative data Adult Salivary Gland    42.6 Adult Heart    13.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    168.7 Adult Testis    32.7 Adult Male Accessory Gland    40.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    69.625 Larval Midgut no informative data Larval Hindgut    17 Larval Malpighian Tubules    32.4 Larval Fat Body no informative data Larval Salivary Gland    30.6 Larval Trachea    18.125 Larval Carcass    29.75 Adult Head    19.6 Adult Eye    21.425 Adult Brain    36.3 Adult Thoracic-Abdominal Ganglion    36.7 Adult Crop    22.5 Adult Midgut    18.7 Adult Hindgut    19.9 Adult Malpighian Tubules    28.5 Adult Fat Body no informative data Adult Salivary Gland    42.6 Adult Heart    13.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    168.7 Adult Testis    32.7 Adult Male Accessory Gland    40.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    69.625 Larval Midgut no informative data Larval Hindgut    17 Larval Malpighian Tubules    32.4 Larval Fat Body no informative data Larval Salivary Gland    30.6 Larval Trachea    18.125 Larval Carcass    29.75 Adult Head    19.6 Adult Eye    21.425 Adult Brain    36.3 Adult Thoracic-Abdominal Ganglion    36.7 Adult Crop    22.5 Adult Midgut    18.7 Adult Hindgut    19.9 Adult Malpighian Tubules    28.5 Adult Fat Body no informative data Adult Salivary Gland    42.6 Adult Heart    13.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    168.7 Adult Testis    32.7 Adult Male Accessory Gland    40.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    19.6   NA  Eye    21.425   NA  Brain    36.3   69.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    36.7   NA  Crop    22.5   no informative data  Midgut    18.7   17  Hindgut    19.9   32.4  Malpighian Tubules    28.5   no informative data  Fat Body    no informative data   30.6  Salivary Gland    42.6   NA  Heart    13.625   18.125  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    168.7   NA  Testis    32.7   NA  Male Accessory Gland    40.2   29.75  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025808 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7825-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Rad17GD4236 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Rad17 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rad17 Class Mutagen Stocks Known lesion Rad17GD4236 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rad17KK101000 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel8160 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4236} NA P{KK101000} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell cycle inferred from electronic annotation with InterPro:IPR004582 (FlyBase Curators et al., 2004-) DNA repair inferred from sequence or structural similarity with UniProtKB:P32641 (FlyBase, 1992-) non-traceable author statement (Brodsky, 1999.1.29)
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR004582 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rad17 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0025808 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41779
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17539 Dere\GG21143 Dgri\GH18931 Dmoj\GI22078 Dper\GL13446 Dpse\GA26853 Dsec\GM25836 Dsim\GD20407 Dvir\GJ22898 Dwil\GK14447 Dyak\GE26434
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP008673-PA Anopheles gambiae (mosquito) XP_001948452.1 Acyrthosiphon pisum (pea aphid) At5g66130.1 Arabidopsis thaliana (wall cress) 127402 Branchiostoma floridae (lancelet) 59930 Branchiostoma floridae (lancelet) ENSBTAP00000002682 Bos taurus (bovine) CAL0004204 Candida albicans (a form of yeast) CBP34036 Caenorhabditis briggsae (nematode) ENSCAFP00000011526 Canis familiaris (dog) CAGL0L11968g Candida glabrata (haploid yeast) Chro.70302 Cryptosporidium hominis (obligate parasite) ENSCINP00000017779 Ciona intestinalis (sea squirt) CMT529C Cyanidioschyzon merolae (red alga) cn02155 Cryptococcus neoformans (yeast-like fungus) cgd7_2660 Cryptosporidium parvum (protozoan parasite) CPIJ003814 Culex pipens (mosquito) ENSCPOP00000000749 Cavia porcellus (guinea pig) RP33980 Caenorhabditis remanei (nematode) 93455 Capitella spl (polychaete worm) DDB0233002 Dictyostelium discoideum (amoeba) 113048 Daphnia pulex (daphnia) ENSDARP00000014749 Danio rerio (zebra fish) ENSECAP00000009271 Equus caballus (horse) XP_651913 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000006697 Gymnopilus aculeatus (mushroom) ENSGALP00000025058 Gallus gallus (chicken) 130916 Hypsipyla robusta (cedar shoot borer) ENSP00000370151 Homo sapiens (human) ISCW013551-PA Ixodes scapularis (deer tick) KLLA0C17820g Kluyveromyces lactis (yeast) 157788 Lottia gigantea (owl limpet) ENSMODP00000024226 Monodelphis domestica (gray opossum) ENSMMUP00000019533 Macaca mulatta (rhesus monkey) ENSMUSP00000022136 Mus musculus (house mouse) 125757 Nematostella vectensis (starlet anemone) ENSOANP00000002583 Ornithorynchus anatinus (platypus) ENSORLP00000021680 Oryzias latipes (japanese killifish) LOC_Os03g13850.1 Oryza sativa (asian rice) 10877 Ostreococcus tauri (green alga) PHUM010232-PA Pediculus humanus (human body louse) 141878 Physcomitrella patens (moss) ENSPPYP00000017352 Pongo pygmaeus (orangutan) 813422 Populus trichocarpa (black cottonwood) ENSPTRP00000029033 Pan troglodytes (chimpanzee) ENSRNOP00000024801 Rattus norvegicus (norway rat) 5030215 Sorghum bicolor (sorghum) YER173W Saccharomyces cerevisiae (budding yeast) SPAC14C4.13 Schizosaccharomyces pombe (fission yeast) XP_001197367.1 Strongylocentrotus purpuratus (purple sea urchin) 18196 Trichoplax adhaerens (metazoa) XP_971233.1 Tribolium castaneum (red flour beetle) ENSTNIP00000013515 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000004947 Takifugu rubripes (pufferfish Takifugu) 82761.m00595 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000039408 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11373 NV20840 LH18927 ISCW013551 FBgn0243456 FBgn0216453 FBgn0210001 FBgn0191879 FBgn0180692 JGI_V11_113048 FBgn0248226 FBgn0151052 FBgn0144807 FBgn0126398 FBgn0113326 FBgn0094557 CPIJ003814 BGIBMGA005367 ACYPI010106 GB19720 AGAP008673 AAEL007649 PHUM491210 GLEAN_05551
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v103552 P{KK101000}VIE-260B v44723 w1118; P{GD4236}v44723/CyO
Genomic Clones ( 1 )
	BACR45M03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 10 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE31829
Other clones	FI02832
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD01844 LD17237 LD27993 LD42548 RE14914
Other clones	148604 Dmel_neb_008177_0948_0494 EK254221
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025808 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41779
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Rad17 CG7825 (Zheng, 1999.11)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142125 RefSeq (Proteins) • NP_650382 DDBJ / EMBL / GenBank • AA539148 AAC95521 AAD31692 AAF55086 AAL48913 AF076839 AF124503 AY071291 BI235878 Entrez Gene - A searchable database of RefSeq genes. • 41779 UniProtKB/TrEMBL • O96532 Q7KND1 Q8SYV6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Checkpoint protein Rad24 (IPR004582)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0025808 DRSC - Results from RNAi screens. • FBgn0025808 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025808 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7825-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025808 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41779 InParanoid A subset of ortholog calls from InParanoid. • AGAP008673-PA Anopheles gambiae (mosquito) XP_001948452.1 Acyrthosiphon pisum (pea aphid) At5g66130.1 Arabidopsis thaliana (wall cress) 127402 Branchiostoma floridae (lancelet) 59930 Branchiostoma floridae (lancelet) ENSBTAP00000002682 Bos taurus (bovine) CAL0004204 Candida albicans (a form of yeast) CBP34036 Caenorhabditis briggsae (nematode) ENSCAFP00000011526 Canis familiaris (dog) CAGL0L11968g Candida glabrata (haploid yeast) Chro.70302 Cryptosporidium hominis (obligate parasite) ENSCINP00000017779 Ciona intestinalis (sea squirt) CMT529C Cyanidioschyzon merolae (red alga) cn02155 Cryptococcus neoformans (yeast-like fungus) cgd7_2660 Cryptosporidium parvum (protozoan parasite) CPIJ003814 Culex pipens (mosquito) ENSCPOP00000000749 Cavia porcellus (guinea pig) RP33980 Caenorhabditis remanei (nematode) 93455 Capitella spl (polychaete worm) DDB0233002 Dictyostelium discoideum (amoeba) 113048 Daphnia pulex (daphnia) ENSDARP00000014749 Danio rerio (zebra fish) ENSECAP00000009271 Equus caballus (horse) XP_651913 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000006697 Gymnopilus aculeatus (mushroom) ENSGALP00000025058 Gallus gallus (chicken) 130916 Hypsipyla robusta (cedar shoot borer) ENSP00000370151 Homo sapiens (human) ISCW013551-PA Ixodes scapularis (deer tick) KLLA0C17820g Kluyveromyces lactis (yeast) 157788 Lottia gigantea (owl limpet) ENSMODP00000024226 Monodelphis domestica (gray opossum) ENSMMUP00000019533 Macaca mulatta (rhesus monkey) ENSMUSP00000022136 Mus musculus (house mouse) 125757 Nematostella vectensis (starlet anemone) ENSOANP00000002583 Ornithorynchus anatinus (platypus) ENSORLP00000021680 Oryzias latipes (japanese killifish) LOC_Os03g13850.1 Oryza sativa (asian rice) 10877 Ostreococcus tauri (green alga) PHUM010232-PA Pediculus humanus (human body louse) 141878 Physcomitrella patens (moss) ENSPPYP00000017352 Pongo pygmaeus (orangutan) 813422 Populus trichocarpa (black cottonwood) ENSPTRP00000029033 Pan troglodytes (chimpanzee) ENSRNOP00000024801 Rattus norvegicus (norway rat) 5030215 Sorghum bicolor (sorghum) YER173W Saccharomyces cerevisiae (budding yeast) SPAC14C4.13 Schizosaccharomyces pombe (fission yeast) XP_001197367.1 Strongylocentrotus purpuratus (purple sea urchin) 18196 Trichoplax adhaerens (metazoa) XP_971233.1 Tribolium castaneum (red flour beetle) ENSTNIP00000013515 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000004947 Takifugu rubripes (pufferfish Takifugu) 82761.m00595 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000039408 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41779 modMine - Data generated by the modENCODE project. • FBgn0025808 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11373 NV20840 LH18927 ISCW013551 FBgn0243456 FBgn0216453 FBgn0210001 FBgn0191879 FBgn0180692 JGI_V11_113048 FBgn0248226 FBgn0151052 FBgn0144807 FBgn0126398 FBgn0113326 FBgn0094557 CPIJ003814 BGIBMGA005367 ACYPI010106 GB19720 AGAP008673 AAEL007649 PHUM491210 GLEAN_05551
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG7825 (Jin et al., 2001, Krause et al., 2001, Keleman et al., 2009.8.5) DmRad17/24 (Krause et al., 2001) Rad17 (Hochwagen, 2006, Greene et al., 2005)
Name Synonym	Rad17
Secondary FlyBase IDs
References ( 19 )
Research paper	Greene et al., 2005, Hum. Molec. Genet. 14(6): 799--811 Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. [FBrf0184023] Herr and Harris, 2004, FEBS Lett. 572(1-3): 147--153 Close head-to-head juxtaposition of genes favors their coordinate regulation in Drosophila melanogaster. [FBrf0179781] Jin et al., 2001, Nature Genetics 29(4): 389--395 The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster. [FBrf0141676] Krause et al., 2001, Molec. Cell. Biol. 21(15): 5156--5168 Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants. [FBrf0137042] Dean et al., 1998, Genomics 54(3): 424--436 cDNA cloning and gene mapping of human homologs for schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. [FBrf0105807]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Review	Hochwagen, 2006, Curr. Biol. 16(6): R217--R228 [FBrf0199069]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Curated genome annotation	Burtis, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126655] Zheng, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126702]
DNA/RNA sequence record	Brodsky, 1999.1.29, GenBank/EMBL/DDBJ: AF124503 Drosophila melanogaster DNA repair protein Rad17 (Rad17) mRNA, complete cds. [FBrf0113478]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]