FlyBase Gene Report: Hsap\APP

(Panikker et al., 2018, Xu et al., 2016, Shaw et al., 2015, Xu et al., 2014, Shaw and Chang, 2013, Pirooznia et al., 2012, Pirooznia et al., 2012)

CEA with Hsap\BACE1^UAS.Exel

(Adedayo et al., 2023, Chocron et al., 2022, Ogunsuyi et al., 2022, Wang et al., 2022, Rimal et al., 2021, Tsakiri et al., 2021, Mhatre et al., 2014)

CEA with Hsap\BACE1^UAS.cUa

(Zhu et al., 2022)

model of Alzheimer's disease 1

CEA

(Mou et al., 2024, Armour et al., 2023, Shao et al., 2022)

CEC

(Wang et al., 2022)

Hsap\APP^695.T.UAS

model of Alzheimer's disease

CEA

(Gunawardena and Goldstein, 2001)

model of inclusion body myositis

CEA

(Kim et al., 2011)

Hsap\APP^{695SPA4CT.UAS.Tag:MYC}

model of Alzheimer's disease

CEA

(Gunawardena and Goldstein, 2001)

Hsap\APP^UAS.YFP

model of Alzheimer's disease 1

CEA

(Mou et al., 2024)

Hsap\APP^UAS.Tag:MYC

model of Alzheimer's disease

CEA

(Rusu et al., 2007)

Hsap\APP^{V717F.LOND.UAS}

model of Alzheimer's disease

CEA

(Gunawardena and Goldstein, 2001)

Hsap\APP^{TNL.Aβ40.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Speretta et al., 2012)

Hsap\APP^{T12.Aβ40.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Speretta et al., 2012)

Hsap\APP^{T22.Aβ40.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Speretta et al., 2012)

Hsap\APP^{TNL.Aβ42.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Speretta et al., 2012)

Hsap\APP^{T12.Aβ42.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Chen et al., 2014, Speretta et al., 2012)

model of Alzheimer's disease 1

CEA

(Taylor et al., 2022, Taylor and Tuxworth, 2019, Tuxworth et al., 2019)

Hsap\APP^{T22.Aβ42.UAS.Tag:SS(nec)}

model of Alzheimer's disease 1

CEA

(Elovsson et al., 2024)

model of Alzheimer's disease

CEA

(Higham et al., 2019, Speretta et al., 2012)

Hsap\APP^{Aβ40.UAS.cSa.Tag:SS(nec)}

model of Alzheimer's disease 1

CEC

(Wacker et al., 2014)

CEA

(Younan et al., 2018)

Hsap\APP^{Aβ42.UAS.cSa.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Chen et al., 2014, Favrin et al., 2013)

model of Alzheimer's disease 1

CEA

(Younan et al., 2018, Ott et al., 2016)

Hsap\APP^{Aβ3Q-42.TRH.UAS}

model of Alzheimer's disease

CEA

(Schilling et al., 2008)

Hsap\APP^2xAPP.SP.UAS

model of Alzheimer's disease

CEA

(Kizil et al., 2022, Fernandez-Funez et al., 2016, Minjarez et al., 2016, Fernandez-Funez et al., 2015, Casas-Tinto et al., 2011)

model of Alzheimer's disease 1

CEC

(Catterson et al., 2023, Deshpande et al., 2023, Kim et al., 2023, Xu et al., 2023)

CEA

(Deshpande et al., 2024, Yu et al., 2020, Coelho et al., 2018, Martín-Peña et al., 2018, Sarkar et al., 2018, Martin-Peña et al., 2017)

CEC with Scer\GAL4^elav.PU

(Yang et al., 2024)

Hsap\APP^1-42.UAS

model of neurodegenerative disease

CEA

(Burr et al., 2014)

model of Alzheimer's disease 1

CEA

(Wang and Davis, 2021)

Hsap\APP^{Aβ42.UAS.Tag:SS(hh)}

model of Alzheimer's disease

CEA

(Hua et al., 2011)

model of Alzheimer's disease 1

CEA

(Harmeier et al., 2009)

Hsap\APP^{Aβ42.5xUAS.cHa}

model of Alzheimer's disease

CEA

(Hua et al., 2011)

Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

model of Alzheimer's disease

CEA

(Fernandez-Funez et al., 2016, Cao et al., 2008, Finelli et al., 2004)

model of neurodegenerative disease

CEA

(Ng et al., 2013)

Hsap\APP^{Arctic.Aβ42.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease

CEA

(Iijima et al., 2008)

model of Alzheimer's disease 1

CEA

(Iijima et al., 2010)

Hsap\APP^{L17P.Aβ42.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease

CEA

(Iijima et al., 2008)

Hsap\APP^695.UAS.Exel

model of Alzheimer's disease

CEA with Hsap\BACE1^UAS.Exel

(da Costa Silva et al., 2022, Maggiore et al., 2022, Malta et al., 2022, Metsla et al., 2022, Vivien Chiu et al., 2017, Wang et al., 2015, Wang et al., 2014)

CEA

(Sarantseva et al., 2009)

CEA with Hsap\BACE1^UAS.Exel, Hsap\MAPT^UAS.VTR

(Yeh et al., 2018)

model of attention deficit hyperactivity disorder

CEA with Hsap\BACE1^UAS.Exel

(Zhang et al., 2015)

Hsap\APP^{770.K670N.M671L.UAS.VTR}

model of Alzheimer's disease

CEA with Hsap\BACE1^UAS.VTR

(Fernandez-Funez et al., 2015)

Hsap\APP^{C99.UAS.Exel.Tag:MYC}

model of Alzheimer's disease 1

CEA

(Rimal et al., 2021, Li et al., 2020, Panchal and Tiwari, 2020)

CEC

(Wang et al., 2022)

Hsap\APP^{Aβ42.UAS.cBa}

model of Alzheimer's disease

CEA

(Wu et al., 2017, Yang et al., 2017, Chouhan et al., 2016, Lee et al., 2016)

model of Alzheimer's disease 1

CEA

(Mukhtar et al., 2024, Ataellahi et al., 2023, Tan et al., 2023, Maggiore et al., 2022, Kim et al., 2021, Moulton et al., 2021, Nikookar et al., 2021, Wang and Davis, 2021, Abtahi et al., 2020, Haghi et al., 2020, Lee et al., 2020, Zhang et al., 2020, Hwang et al., 2019, Mattioli et al., 2019)

CEC

(Khatoon et al., 2022)

Hsap\APP^{Aβ42.E693G.UAS.VTR}

model of Alzheimer's disease 1

CEC

(Oyarce-Pezoa et al., 2023, Huang et al., 2022, Demirev et al., 2019, Tower et al., 2019)

CEA

(Panchal and Tiwari, 2020, Yeh et al., 2018, Ray et al., 2017, Breda et al., 2016)

Hsap\APP^{Aβ42.D694N.UAS.VTR}

model of Alzheimer's disease 1

CEA

(Metsla et al., 2022)

Hsap\APP^{Aβ40.UAS.Tag:SS(nec)}

model of Alzheimer's disease 1

CEC

(Wacker et al., 2014)

CEA

(López-Arias et al., 2017, Tabuchi et al., 2015)

Hsap\APP^{L17R.UAS.Tag:SS(nec)}

DOES NOT model Alzheimer's disease

CEA

(Luheshi et al., 2007)

Hsap\APP^{F20E.UAS.Tag:SS(nec)}

DOES NOT model Alzheimer's disease

CEA

(Luheshi et al., 2007)

Hsap\APP^{D7R.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Luheshi et al., 2007)

Hsap\APP^{K16W.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Luheshi et al., 2007)

Hsap\APP^{R5Y.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Luheshi et al., 2007)

Hsap\APP^{A2F.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Luheshi et al., 2007)

Hsap\APP^{H14W.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Luheshi et al., 2007)

Hsap\APP^{E11G.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Luheshi et al., 2007)

Hsap\APP^{N27W.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Luheshi et al., 2007)

Hsap\APP^{M35F.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Luheshi et al., 2007)

Hsap\APP^{H6WE22G.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Luheshi et al., 2007)

Hsap\APP^{G9TE22G.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Luheshi et al., 2007)

Hsap\APP^{F4DE22G.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(McKoy et al., 2012, Luheshi et al., 2007)

Hsap\APP^{I31EE22G.UAS.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Luheshi et al., 2007)

Hsap\APP^{Arctic.Aβ42.UAS.cJa.Tag:SS(nec)}

model of Alzheimer's disease

CEA

(Chen et al., 2014, Favrin et al., 2013, Kruppa et al., 2013, Jahn et al., 2011)

model of Alzheimer's disease 1

CEA

(Wilson et al., 2024, Yu et al., 2024, Younan et al., 2018, Ott et al., 2016)

Hsap\APP^{Aβ40.UAS.cUa}

model of Alzheimer's disease 1

CEC

(Wacker et al., 2014)

CEA

(Fang et al., 2012)

Hsap\APP^{Aβ40.UAS.Tag:SS(rPENK)}

DOES NOT model Alzheimer's disease

CEA

(Iijima et al., 2004)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

model of Kennedy's disease

CEA

(Pandey et al., 2007)

model of Alzheimer's disease

CEA

(Bergkvist et al., 2020, Sun et al., 2018, Helmfors et al., 2015, Costa et al., 2011, Kumar et al., 2011, Zhao et al., 2010, Rival et al., 2009, Luheshi et al., 2007, Crowther et al., 2005)

CEA with Hsap\APP^UAS.cUa

(Bergkvist et al., 2016)

Hsap\APP^{Aβ42.UAS.cUa}

model of Alzheimer's disease 1

CEA

(Huang et al., 2024, Singh et al., 2024, Myers et al., 2022, Cheng et al., 2021, He et al., 2021, Li et al., 2021, Ibrahim et al., 2020, Irwin et al., 2020, Panchal and Tiwari, 2020, Saburova et al., 2017, Moran et al., 2013, Fang et al., 2012)

CEC

(Li et al., 2023)

model of neurodegenerative disease

CEA

(Tare et al., 2011)

model of Alzheimer's disease

CEA

(Cutler et al., 2015, Nevzglyadova et al., 2015, McKoy et al., 2014, Folwell et al., 2010)

CEA with Hsap\MAPT^UAS.1N4R

(Folwell et al., 2010)

Hsap\APP^{Aβ42.UAS.cMa.Tag:SS(nec),Tag:polyHis}

model of amyloidosis

CEA

(Marcora et al., 2014)

Hsap\APP^{Aβ40.UAS.Tag:SS(nec).cBa}

model of Alzheimer's disease

CEA with Hsap\APP^{Aβ42.UAS.Tag:SS(nec).cBa}

(Burnouf et al., 2015)

CEA with Hsap\APP^{Aβ43.UAS.Tag:SS(nec).cBa}

(Burnouf et al., 2015)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec).cBa}

model of Alzheimer's disease

CEA

(Burnouf et al., 2015)

model of Alzheimer's disease 1

CEC

(Gorsky et al., 2017)

CEA

(Xue et al., 2022)

Hsap\APP^{Aβ43.UAS.Tag:SS(nec).cBa}

model of Alzheimer's disease

CEA

(Burnouf et al., 2015)

Hsap\APP^{1-42.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease

CEA

(Jonson et al., 2015)

model of Alzheimer's disease 1

CEC

(Farkas et al., 2023)

Hsap\APP^{1-43.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease

CEA

(Jonson et al., 2015)

Hsap\APP^{3-42.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease 1

CEA

(Chocron et al., 2022)

model of Alzheimer's disease

CEA

(Jonson et al., 2015)

Hsap\APP^{11-42.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease

CEA

(Jonson et al., 2015)

Hsap\APP^{3-43.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease

CEA

(Jonson et al., 2015)

Hsap\APP^{3-42.E3A.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease

CEA

(Jonson et al., 2015)

Hsap\APP^{11-42.E11A.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease

CEA

(Jonson et al., 2015)

Hsap\APP^{1-42.A42W.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease

CEA

(Jonson et al., 2015)

Hsap\APP^UAS.cUa

model of Alzheimer's disease 1

CEC

(Lee et al., 2012)

CEA with Hsap\BACE1^UAS.cUa

(Hou et al., 2014)

model of Alzheimer's disease

CEA

(Saburova et al., 2017)

CEA with Hsap\BACE1^UAS.cGa

(Saburova et al., 2017)

CEA with Hsap\BACE1^UAS.cUa

(Bergkvist et al., 2020, Li et al., 2020, Dissel et al., 2017, Sandin et al., 2016)

CEA with Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

(Bergkvist et al., 2016)

Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease

CEA

(Sekiya et al., 2018, Belfiori-Carrasco et al., 2017, Gerstner et al., 2017, Singh et al., 2017, Lee et al., 2016, Ling et al., 2014, Singh et al., 2014, Lang et al., 2013, Singh et al., 2013, Lang et al., 2012, Wang et al., 2012, Ling and Salvaterra, 2011, Ling et al., 2009, Iijima et al., 2008, Iijima et al., 2004)

model of Alzheimer's disease 1

CEC

(Deolankar et al., 2023, Hsieh and Chiang, 2023, Liu et al., 2023, Miyazaki et al., 2019, Lee et al., 2012)

CEA

(Mou et al., 2024, Cheng et al., 2022, Ring et al., 2022, Shao et al., 2022, Wang et al., 2021, Kikuchi et al., 2020, Feng et al., 2018, Hahm et al., 2018, Ruland et al., 2018, Chiang et al., 2010)

model of tauopathy

CEA

(Chiang et al., 2009)

model of neurodegenerative disease

CEA

(Ng et al., 2013)

model of Parkinson's disease

CEA

(Iijima-Ando et al., 2009)

Hsap\APP^{Arctic.Aβ42.QUAS.Tag:SS(nec)}

model of Alzheimer's disease 1

CEA

(Niccoli et al., 2016)

Hsap\APP^{Aβ42.Tag:SS(rPENK)}

model of Alzheimer's disease 1

CEA

(Omata et al., 2014)

Hsap\APP^{L17P.Aβ42.Tag:SS(rPENK)}

model of Alzheimer's disease 1

CEA

(Omata et al., 2014)

Hsap\APP^{E22G.Aβ42.Tag:SS(rPENK)}

model of Alzheimer's disease 1

CEA

(Omata et al., 2014)

Hsap\APP^{S8D.Aβ42.Tag:SS(rPENK)}

model of Alzheimer's disease 1

CEA

(Omata et al., 2014)

Hsap\APP^{3Q42.Aβ42.Tag:SS(rPENK)}

model of Alzheimer's disease 1

CEA

(Sofola-Adesakin et al., 2016)

CEA with Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

(Sofola-Adesakin et al., 2016)

Hsap\APP^{Dut40.Tag:SS(rPENK)}

model of Alzheimer's disease 1

CEC

(Yamasaki et al., 2018)

Hsap\APP^{Arctic.Aβ42.lexAop.Tag:SS(nec)}

model of Alzheimer's disease 1

CEA

(Tabuchi et al., 2015)

CEC

(Hsieh and Chiang, 2023)

Hsap\APP^{Aβ42.UAS.cSa}

model of Alzheimer's disease 1

CEC

(Stapper and Jahn, 2018)

Hsap\APP^Aβ42.lexAop

model of Alzheimer's disease 1

CEC

(Stapper and Jahn, 2018)

Hsap\APP^{Aβ42.QUAS.Tag:SS(nec)}

model of Alzheimer's disease 1

CEC

(Sheng et al., 2023)

CEA

(Catterson et al., 2024, Li et al., 2018)

Hsap\APP^{Aβ40.QUAS.Tag:SS(nec)}

model of Alzheimer's disease 1

CEC

(Catterson et al., 2024)

Hsap\APP^{Aβ42.G29A.G33A.UAS.Tag:SS(hh)}

model of Alzheimer's disease 1

CEA

(Harmeier et al., 2009)

Hsap\APP^{Aβ42.G33I.UAS.Tag:SS(hh)}

DOES NOT model Alzheimer's disease 1

CEA

(Harmeier et al., 2009)

Hsap\APP^{1-42.UAS.CRY2(PHR),mCherry}

model of Alzheimer's disease 1

CEA

(Kaur et al., 2022, Lim et al., 2020)

Hsap\APP^{Arctic.Aβ42.20xUAS.Tag:SS(nec)}

model of Alzheimer's disease 1

CEA

(Sowade and Jahn, 2017)

Hsap\APP^{Aβ42.UAS.Tag:SS(aos)}

model of Alzheimer's disease 1

CEA

(De Mena et al., 2020)

Hsap\APP^{UAS.695.mRFP.EGFP}

model of Alzheimer's disease 1

CEA

(Long et al., 2024, Ramaker et al., 2016)

Hsap\APP^{Aβ42.UAS.cAa.Tag:SS(nec)}

model of Alzheimer's disease 1

CEA

(Allan et al., 2014)

Hsap\APP^{Aβ42.UAS.cAb.Tag:SS(nec)}

model of Alzheimer's disease 1

CEA

(Allan et al., 2014)

Hsap\APP^{3-42.E3Q.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease 1

CEA

(Tsuda et al., 2017)

Hsap\APP^{Aβ42.UAS.cTa.Tag:SS(rPENK)}

model of Alzheimer's disease 1

CEA

(Tsuda et al., 2017)

Hsap\APP^{C99.V717I.UAS}

model of Alzheimer's disease 1

CEA

(Lee et al., 2020)

Hsap\APP^{Arctic.Aβ42.UAS.cUa}

model of Alzheimer's disease 1

CEA

(Sun et al., 2022, Fang et al., 2012)

Hsap\APP^ICD.695.HA

model of Alzheimer's disease 1

CEA

(Long et al., 2024)

Hsap\APP^UAS.cLa.EGFP

model of Alzheimer's disease 1

CEA

(Li et al., 2024)

Hsap\APP^{Δ41-50.UAS.EGFP}

model of Alzheimer's disease 1

CEA

(Li et al., 2024)

Hsap\APP^{Aβ42.H6A.H14A.UAS}

model of Alzheimer's disease 1

CEA

(Ott et al., 2015)

Hsap\APP^{Aβ42.H13A.H14A.UAS}

model of Alzheimer's disease 1

CEA

(Ott et al., 2015)

Hsap\APP^{Aβ42.H6A.H13A.H14A.UAS}

model of Alzheimer's disease 1

CEA

(Ott et al., 2015)

Hsap\APP^695.QUAS

model of Alzheimer's disease 1

CEA

(Mou et al., 2024)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 43 )

Allele

Disease

Interaction

References

Hsap\APP^{695-Swedish.UAS}

model of Alzheimer's disease

is exacerbated by Khc⁸

(Gunawardena and Goldstein, 2001)

is exacerbated by Klc^8ex94

(Gunawardena and Goldstein, 2001)

is ameliorated by robl^K

(Gunawardena and Goldstein, 2001)

model of Alzheimer's disease 1

is ameliorated by Psn¹⁴³

(Gunawardena et al., 2013)

is ameliorated by Psn^I2

(Gunawardena et al., 2013)

Hsap\APP^{695-Swedish.UAS.Tag:MYC}

model of Alzheimer's disease 1

is ameliorated by yata^KE2.1

(Furotani et al., 2018)

is ameliorated by yata^NIG.1973R

(Furotani et al., 2018)

is ameliorated by Dhc64C^JF03177

(Du et al., 2021)

is ameliorated by syd^GLC01419

(Du et al., 2021)

Hsap\APP^695.UAS

model of Alzheimer's disease

is ameliorated by polo^GL00014

(Peng et al., 2015)

is ameliorated by polo^HMS00530

(Peng et al., 2015)

is ameliorated by polo¹

(Peng et al., 2015)

is ameliorated by Psn^B3

(Greeve et al., 2004)

is exacerbated by Psn^L235P.UAS

(Greeve et al., 2004)

is ameliorated by Rab5^{S43N.UASp.YFP}

(Xu et al., 2016)

model of Alzheimer's disease 1

is ameliorated by Atg12^JF02704

(Zhuang et al., 2020)

is ameliorated by Atg13^Δ81

(Zhuang et al., 2020)

is ameliorated by Atg7^JF02787

(Zhuang et al., 2020)

is ameliorated by STUB1^HMS00889

(Zhuang et al., 2020)

is ameliorated by STUB1^HMS00986

(Zhuang et al., 2020)

is ameliorated by STUB1^I

(Zhuang et al., 2020)

is ameliorated by Psn¹⁴³

(Gunawardena et al., 2013)

is ameliorated by Psn^I2

(Gunawardena et al., 2013)

Hsap\APP^{695.UAS.Tag:MYC}

model of Alzheimer's disease

is exacerbated by sra^JF02557

(Shaw and Chang, 2013)

is exacerbated by Pp2B-14D^Act.Δ.UAS

(Shaw and Chang, 2013)

is ameliorated by CanB^JF02616

(Shaw et al., 2015, Shaw and Chang, 2013)

is ameliorated by sgg¹

(Shaw and Chang, 2013)

is exacerbated by sra¹

(Shaw and Chang, 2013)

is ameliorated by sra^UAS.Tag:HA

(Shaw et al., 2015, Shaw and Chang, 2013)

is ameliorated by Tip60^UAS.cLa

(Xu et al., 2016, Xu et al., 2014, Johnson et al., 2013, Pirooznia et al., 2012)

is ameliorated by Tip60^UAS.cPa

(Panikker et al., 2018, Pirooznia et al., 2012)

is ameliorated by Pka-C1^UAS.Tag:FLAG

(Shaw et al., 2015)

is exacerbated by Tip60^E431Q.UAS

(Xu et al., 2016, Johnson et al., 2013)

model of Alzheimer's disease 1

is ameliorated by Ca-α1D^HMS00294

(Shao et al., 2022)

is ameliorated by CanB^JF02616

(Shao et al., 2022)

is ameliorated by Itpr^JF01957

(Shao et al., 2022)

is ameliorated by Mmmm\PV^UAS.Tag:MYC

(Shao et al., 2022)

is ameliorated by NFAT^Δa1

(Shao et al., 2022)

is ameliorated by NFAT^Δab

(Shao et al., 2022)

is ameliorated by NFAT^Δb

(Shao et al., 2022)

is ameliorated by SARS-CoV-2\nsp1^UAS.cZa

(Wang et al., 2022)

is ameliorated by Adk2^GD6724

(Huichalaf et al., 2019)

is ameliorated by Pdk1^GD7480

(Huichalaf et al., 2019)

is ameliorated by inaC^KK105562

(Huichalaf et al., 2019)

is ameliorated by rl^GD12910

(Huichalaf et al., 2019)

Hsap\APP^695.T.UAS

model of Alzheimer's disease

is exacerbated by Klc^8ex94

(Gunawardena and Goldstein, 2001)

is exacerbated by Khc⁸

(Gunawardena and Goldstein, 2001)

is ameliorated by robl^K

(Gunawardena and Goldstein, 2001)

exacerbates neurodegenerative disease

modeled by Hsap\MAPT^R406W.UAS

(Wang et al., 2007)

model of neurodegenerative disease

is exacerbated by par-1^UAS.Tag:MYC

(Wang et al., 2007)

is exacerbated by Hsap\MAPT^R406W.UAS

(Wang et al., 2007)

model of inclusion body myositis

is ameliorated by Hsap\PRKN^UAS.Tag:MYC

(Kim et al., 2011)

Hsap\APP^{695SPA4CT.UAS.Tag:MYC}

model of Alzheimer's disease

is ameliorated by robl^K

(Gunawardena and Goldstein, 2001)

is exacerbated by Khc⁸

(Gunawardena and Goldstein, 2001)

is exacerbated by Klc^8ex94

(Gunawardena and Goldstein, 2001)

Hsap\APP^{V717F.LOND.UAS}

model of Alzheimer's disease

is exacerbated by Khc⁸

(Gunawardena and Goldstein, 2001)

is ameliorated by robl^K

(Gunawardena and Goldstein, 2001)

is exacerbated by Klc^8ex94

(Gunawardena and Goldstein, 2001)

Hsap\APP^{T12.Aβ42.UAS.Tag:SS(nec)}

model of Alzheimer's disease 1

is ameliorated by nbs¹

(Tuxworth et al., 2019)

is ameliorated by Ku80^RNAi.UAS.cUa

(Taylor and Tuxworth, 2019)

is ameliorated by p53^RNAi.UAS.cUa

(Taylor and Tuxworth, 2019)

is ameliorated by mei-41^RNAi.UAS.cUa

(Taylor et al., 2022)

is ameliorated by tefu^GL00138

(Taylor et al., 2022)

is ameliorated by grp^JF02588

(Taylor et al., 2022)

is ameliorated by lok^GL00020

(Taylor et al., 2022)

Hsap\APP^{Aβ40.UAS.cSa.Tag:SS(nec)}

model of Alzheimer's disease 1

is exacerbated by Zzzz\VHH^{KW1.UAS.Tag:SS(nec),Tag:MYC}

(Wacker et al., 2014)

is exacerbated by Oari\PrP^VRQ.UAS

(Younan et al., 2018)

Hsap\APP^{Aβ42.UAS.cSa.Tag:SS(nec)}

model of Alzheimer's disease 1

is exacerbated by Oari\PrP^VRQ.UAS

(Younan et al., 2018)

Hsap\APP^2xAPP.SP.UAS

model of Alzheimer's disease

is exacerbated by Rho1^RNAi.UAS.cBa

(Minjarez et al., 2016)

is exacerbated by Pgm1^HMS01333

(Minjarez et al., 2016)

is ameliorated by Hsap\HSPA1L^UAS.sec

(Fernandez-Funez et al., 2016)

is ameliorated by Hsap\HSPA1L^K71E.UAS.sec

(Fernandez-Funez et al., 2016)

is ameliorated by Mmus\Xbp1^UAS.cCTa

(Casas-Tinto et al., 2011)

is exacerbated by Xbp1^GD4745

(Casas-Tinto et al., 2011)

is ameliorated by Xbp1^d08698

(Casas-Tinto et al., 2011)

is ameliorated by Mus\scFv^{9.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

is ameliorated by Mus\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

is ameliorated by Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

is ameliorated by Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

is exacerbated by Gcat^HMC02902

(Kizil et al., 2022)

model of Alzheimer's disease 1

is ameliorated by Nsun2^UAS.cAa

(Kim et al., 2023)

is ameliorated by Hsap\NAT9^AAA.UAS

(Deshpande et al., 2023)

is ameliorated by Hsap\NAT9^UAS.cMa

(Deshpande et al., 2023)

is ameliorated by Mnat9^AAA.UAS

(Deshpande et al., 2023)

is ameliorated by Mnat9^AcDel.UAS

(Deshpande et al., 2023)

is exacerbated by Mnat9^KK109382

(Deshpande et al., 2023)

is ameliorated by Mnat9^{UAS.ORF.GW.Tag:HA}

(Deshpande et al., 2023)

is ameliorated by Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}

(Martin-Peña et al., 2017)

is ameliorated by Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}

(Martin-Peña et al., 2017)

is ameliorated by EndoA^UAS.cVa

(Yu et al., 2020)

is exacerbated by Rab4^UASp.YFP

(Yu et al., 2020)

is exacerbated by Rab7^UAS.GFP

(Yu et al., 2020)

is exacerbated by Rab10^UASp.YFP

(Yu et al., 2020)

is ameliorated by Amph^A.UAS

(Yu et al., 2020)

is ameliorated by EndoA^UAS.cUa

(Yu et al., 2020)

is exacerbated by Rab10^UAS.cUa

(Yu et al., 2020)

is exacerbated by Rab11^{UAS.ORF.Tag:HA}

(Yu et al., 2020)

is exacerbated by Rab4^UAS.cUa

(Yu et al., 2020)

is ameliorated by Rab5^UAS.EGFP

(Yu et al., 2020)

is exacerbated by Rab8^{UAS.ORF.GW.Tag:HA}

(Yu et al., 2020)

is ameliorated by lap^A.UAS

(Yu et al., 2020)

is exacerbated by lap^HMS01939

(Yu et al., 2020)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Martín-Peña et al., 2018)

is ameliorated by Hsap\HSPA1L^UAS.sec

(Martín-Peña et al., 2018)

is ameliorated by Gmax\Lun^UAS.EGFP

(Sarkar et al., 2018)

is exacerbated by Jra^Asp.B.UAS

(Sarkar et al., 2018)

is exacerbated by hep^Act.UAS.cUa

(Sarkar et al., 2018)

is exacerbated by azot^GD7219

(Coelho et al., 2018)

is exacerbated by Diap1^UAS.cHa

(Coelho et al., 2018)

is exacerbated by azot^KK111538

(Coelho et al., 2018)

is ameliorated by azot^mCherry

(Coelho et al., 2018)

is exacerbated by fwe^{RNAi.UASp.Lhp}

(Coelho et al., 2018)

is ameliorated by LanB1^EP-600

(Catterson et al., 2023)

is ameliorated by Col4a1^UAS.mRFP1

(Catterson et al., 2023)

is ameliorated by bumpel^{UAS.ORF.GW.Tag:HA}

(Xu et al., 2023)

is exacerbated by mir-277⁸⁴

(Deshpande et al., 2024)

is ameliorated by mir-277^UAS.cUa

(Deshpande et al., 2024)

Hsap\APP^1-42.UAS

model of Alzheimer's disease 1

is ameliorated by EDTP^HMS01577

(Xiao et al., 2019)

Hsap\APP^{Aβ42.UAS.Tag:SS(hh)}

model of Alzheimer's disease

is ameliorated by MTF-1^UAS.cHa

(Hua et al., 2011)

is ameliorated by MtnA^UAS.cHa

(Hua et al., 2011)

is ameliorated by Hsap\MT3^UAS.cHa

(Hua et al., 2011)

is exacerbated by MTF-1^unspecified

(Hua et al., 2011)

Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

model of Alzheimer's disease

is exacerbated by mir-282^EP3041

(Cao et al., 2008)

is ameliorated by CG2924^EP1596

(Cao et al., 2008)

is exacerbated by CG7231^EP2510

(Cao et al., 2008)

is exacerbated by svr^KG02090

(Cao et al., 2008)

is exacerbated by elB⁹

(Cao et al., 2008)

is exacerbated by Nep2^KG05754

(Cao et al., 2008)

is exacerbated by SNF4Aγ^KG10152

(Cao et al., 2008)

is exacerbated by ATP7^EY07895

(Cao et al., 2008)

is exacerbated by cwo^EP3470

(Cao et al., 2008)

is exacerbated by Sin3A⁰⁸²⁶⁹

(Cao et al., 2008)

is exacerbated by SNF4Aγ^EP3015b

(Cao et al., 2008)

is exacerbated by elB^EP965

(Cao et al., 2008)

is exacerbated by mub^EP3108

(Cao et al., 2008)

is ameliorated by g^EP514

(Cao et al., 2008)

is exacerbated by HDAC1⁰⁴⁵⁵⁶

(Cao et al., 2008)

is exacerbated by HDAC4^KG09091

(Cao et al., 2008)

is exacerbated by Prps^KG00420

(Cao et al., 2008)

is exacerbated by Tl^EP1051

(Cao et al., 2008)

is exacerbated by esg^EP684

(Cao et al., 2008)

is ameliorated by g^B166

(Cao et al., 2008)

is exacerbated by Sap130^EY12079

(Cao et al., 2008)

is ameliorated by Nep2^EP3549

(Cao et al., 2008, Finelli et al., 2004)

is exacerbated by svr¹²⁶

(Cao et al., 2008)

is exacerbated by svr^EP356

(Cao et al., 2008)

is exacerbated by Dsp1^EP355

(Cao et al., 2008)

is ameliorated by Dyro^EP3405

(Cao et al., 2008)

is exacerbated by MESR4^EP386

(Cao et al., 2008)

is ameliorated by Hsap\HSPA1L^UAS.sec

(Fernandez-Funez et al., 2016)

Hsap\APP^{Arctic.Aβ42.UAS.Tag:SS(rPENK)}

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Iijima et al., 2010)

model of Alzheimer's disease 1

is exacerbated by p53^259H.GUS

(Iijima et al., 2010)

is exacerbated by p53^Ct.GUS

(Iijima et al., 2010)

Hsap\APP^{C99.UAS.Exel.Tag:MYC}

model of Alzheimer's disease 1

is ameliorated by Hsap\TMEM59^UAS.cLa

(Li et al., 2020)

is ameliorated by Miro^UAS.cGa

(Panchal and Tiwari, 2020)

is ameliorated by SARS-CoV-2\nsp1^UAS.cZa

(Wang et al., 2022)

is ameliorated by CG11414^HMJ23120

(Rimal et al., 2021)

is ameliorated by CG6769^{UAS.ORF.GW.Tag:HA}

(Rimal et al., 2021)

is ameliorated by Ltn1^G9156

(Rimal et al., 2021)

is ameliorated by TER94^UAS.cRa

(Rimal et al., 2021)

is ameliorated by pelo^{UAS.ORF.GW.Tag:HA}

(Rimal et al., 2021)

Hsap\APP^{Aβ42.UAS.cBa}

model of Alzheimer's disease

is exacerbated by sra^EY07182

(Lee et al., 2016)

is ameliorated by Hsap\CCN2^UAS.cYa

(Yang et al., 2017)

is ameliorated by Hsap\CCN2^repo.PY

(Yang et al., 2017)

model of Alzheimer's disease 1

is ameliorated by CG6154^MI08916

(Kim et al., 2021)

is ameliorated by CG7137^GD12147

(Kim et al., 2021)

is ameliorated by CG5567^GD11694

(Kim et al., 2021)

is ameliorated by kek3^GD1733

(Kim et al., 2021)

is exacerbated by CG7896^KK105990

(Kim et al., 2021)

is ameliorated by CG8888^EY12413

(Kim et al., 2021)

is ameliorated by Cont^GD12610

(Kim et al., 2021)

is ameliorated by kek5^MI01444

(Kim et al., 2021)

is exacerbated by Cox11^KK100158

(Kim et al., 2021)

is ameliorated by Dgkε^ox-1

(Kim et al., 2021)

is exacerbated by plx^KK100306

(Kim et al., 2021)

is exacerbated by E2f1^KK100304

(Kim et al., 2021)

is ameliorated by Hydr2^MI08405

(Kim et al., 2021)

is ameliorated by sro^GD7469

(Kim et al., 2021)

is ameliorated by Thg^GD11217

(Kim et al., 2021)

is exacerbated by VhaM9.7-a^KK107389

(Kim et al., 2021)

is ameliorated by Parp1^HMC04658

(Maggiore et al., 2022)

is ameliorated by Tip60^UAS.cLa

(Zhang et al., 2020)

is ameliorated by Acer^Δ168

(Lee et al., 2020)

is exacerbated by Pten^UAS.cUa

(Hwang et al., 2019)

Hsap\APP^{Aβ42.E693G.UAS.VTR}

model of Alzheimer's disease 1

is ameliorated by brp^+t83.4

(Huang et al., 2022)

is exacerbated by Jra^JF01184

(Ray et al., 2017)

is exacerbated by Stat92E^GD4492

(Ray et al., 2017)

is exacerbated by drpr^Δ5

(Ray et al., 2017)

is ameliorated by drpr^I.UAS

(Ray et al., 2017)

is exacerbated by drpr^RNAi.UAS

(Ray et al., 2017)

is exacerbated by kay^JF01380

(Ray et al., 2017)

is ameliorated by Hsap\PLD3^{UAS.Tag:FLAG,Tag:HA}

(Demirev et al., 2019)

is NOT ameliorated by Hsap\PLD3^{V232M.UAS.Tag:FLAG,Tag:HA}

(Demirev et al., 2019)

is ameliorated by Miro^UAS.cGa

(Panchal and Tiwari, 2020)

Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

model of Alzheimer's disease 1

is ameliorated by MCU¹

(Twyning et al., 2024)

is ameliorated by Pdzd8^NIG.10362R

(Hewitt et al., 2022)

is ameliorated by stmA¹

(Zhang et al., 2017)

is ameliorated by stmA^rev499

(Zhang et al., 2017)

is exacerbated by Glut1^HMS02152

(Niccoli et al., 2016)

is ameliorated by Glut1^UAS.cNa

(Niccoli et al., 2016)

is exacerbated by Ldh^HMS00039

(Niccoli et al., 2021)

is exacerbated by Ldh^UAS.cNa

(Niccoli et al., 2021)

is exacerbated by crc^JF02007

(Niccoli et al., 2021)

is ameliorated by LanB1^EP-600

(Catterson et al., 2023)

is ameliorated by LanB1^UAS.mRFP1

(Catterson et al., 2023)

is ameliorated by LanB2^UAS.GFP

(Catterson et al., 2023)

is exacerbated by Xbp1^KK102632

(Catterson et al., 2023)

is ameliorated by Avic\GFP^{UAS.Tag:ER(KDEL)}

(Catterson et al., 2023)

is exacerbated by Avic\GFP^{UAS.Tag:SS(wg)}

(Catterson et al., 2023)

is ameliorated by Col4a1^UAS.mRFP1

(Catterson et al., 2023)

is ameliorated by LanA^EY02207

(Catterson et al., 2023)

is ameliorated by Hsap\LYZ^{UAS.Tag:SS(nec)}

(Sandin et al., 2016)

model of Alzheimer's disease

is ameliorated by Saur\spa^{2.ZAβ3.UAS.Tag:MYC,Tag:SS(nec)}

(Luheshi et al., 2010)

is ameliorated by Saur\spa^{ZAβ3.UAS.Tag:MYC,Tag:SS(nec)}

(Luheshi et al., 2010)

is ameliorated by Sod2^UAS.cMa

(Rival et al., 2009)

is ameliorated by Fer2LCH^UAS.cRa

(Rival et al., 2009)

is exacerbated by Sod1^UAS.cAa

(Rival et al., 2009)

is ameliorated by Sod1^RNAi.UAS.cHa

(Rival et al., 2009)

is ameliorated by GstS1^UASp.cWa

(Rival et al., 2009)

is ameliorated by Fer1HCH^UAS.cRa

(Rival et al., 2009)

is ameliorated by Cat^UAS.cAa

(Rival et al., 2009)

is ameliorated by Sod1ⁿ¹

(Rival et al., 2009)

is NOT exacerbated by per⁰¹

(Long et al., 2014)

is ameliorated by NT1^Cysknot.UAS

(Lim et al., 2015)

is ameliorated by sgg^S9E.UAS

(Sofola et al., 2010)

is ameliorated by tau^MR22

(Sofola et al., 2010)

is ameliorated by tau^EP3203

(Sofola et al., 2010)

Hsap\APP^{Arctic.Aβ42.UAS.cJa.Tag:SS(nec)}

model of Alzheimer's disease

is ameliorated by PGRP-SC1b^GD5490

(Favrin et al., 2013)

is ameliorated by CG14715^KK104150

(Favrin et al., 2013)

is ameliorated by CG14715^GD4788

(Favrin et al., 2013)

is ameliorated by Sod3^GD4801

(Favrin et al., 2013)

is ameliorated by CG14715^G6908

(Favrin et al., 2013)

model of Alzheimer's disease 1

is ameliorated by CG9853^KK102820

(Wilson et al., 2024)

is exacerbated by Oari\PrP^VRQ.UAS

(Younan et al., 2018)

is exacerbated by Nmdmc^RNAi.UAS.cUa

(Yu et al., 2024)

is ameliorated by Nmdmc^UAS.Tag:HA

(Yu et al., 2024)

Hsap\APP^{Aβ40.UAS.cUa}

model of Alzheimer's disease 1

is exacerbated by Zzzz\VHH^{KW1.UAS.Tag:SS(nec),Tag:MYC}

(Wacker et al., 2014)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

model of Kennedy's disease

is ameliorated by HDAC6^UAS.Tag:V5

(Pandey et al., 2007)

model of Alzheimer's disease

is ameliorated by Fer1HCH^UAS.cRa

(Rival et al., 2009)

is exacerbated by Sod1^UAS.cAa

(Rival et al., 2009)

is ameliorated by Cat^UAS.cAa

(Rival et al., 2009)

is ameliorated by Fer2LCH^UAS.cRa

(Rival et al., 2009)

is ameliorated by Hsap\LYZ^{UAS.Tag:SS(nec)}

(Helmfors et al., 2015)

is exacerbated by Hsap\HYCC1^UAS.cSa

(Sun et al., 2018)

is ameliorated by Hyccin^KK108796

(Sun et al., 2018)

is ameliorated by Ttc7^k15603

(Sun et al., 2018)

is exacerbated by Ttc7^EY09582

(Sun et al., 2018)

model of Alzheimer's disease 1

is ameliorated by Disc\RFP^{mRFP.UAS.cGa.Tag:Mito(mAkap1),Tag:ER(yUBC6)}

(Garrido-Maraver et al., 2020)

is ameliorated by Hsap\SFTPC^{BRICHOS.UAS.Tag:SS(hSFTPB)}

(Poska et al., 2016, Hermansson et al., 2014)

is ameliorated by Hsap\ITM2B^{BRICHOS.UAS.Tag:SS(hSFTPB)}

(Poska et al., 2016)

is ameliorated by Lnk^UAS.cSb

(Shen et al., 2016)

is exacerbated by Lnk^unspecified

(Shen et al., 2016)

is ameliorated by Hsap\TXN^80.UAS

(Gerenu et al., 2021)

is ameliorated by Hsap\LYZ^{UAS.Tag:SS(nec)}

(Sandin et al., 2016)

is ameliorated by Pi3K92E^UAS.Tag:MYC

(López-Arias et al., 2017)

Hsap\APP^{Aβ42.UAS.cUa}

model of Alzheimer's disease 1

is exacerbated by dac^UAS.cSa

(Moran et al., 2013)

is ameliorated by tio^{ΔPLDLS.UAS.cDa}

(Moran et al., 2013)

is ameliorated by tio^{ΔZn1.UAS.cDa}

(Moran et al., 2013)

is ameliorated by pan^ΔN.UAS

(Moran et al., 2013)

is ameliorated by tio^{ΔZn2.UAS.cDa}

(Moran et al., 2013)

is exacerbated by so^UAS.cPa

(Moran et al., 2013)

is ameliorated by tio^{ΔZn3.UAS.cDa}

(Moran et al., 2013)

is ameliorated by tsh^ΔZn1.UAS

(Moran et al., 2013)

is ameliorated by tio^{ΔZn4.UAS.cDa}

(Moran et al., 2013)

is ameliorated by tio^UAS.cLa

(Moran et al., 2013)

is ameliorated by tsh^ΔPLDLS.UAS

(Moran et al., 2013)

is ameliorated by tsh^ΔZn2.UAS

(Moran et al., 2013)

is ameliorated by tsh^ΔZn3.UAS

(Moran et al., 2013)

is ameliorated by tsh^UAS.cGa

(Moran et al., 2013)

is ameliorated by yki^{UAS.cOa.Tag:V5}

(Irwin et al., 2020)

is exacerbated by yki^RNAi.N.UAS

(Irwin et al., 2020)

is exacerbated by Jra^Asp.B.UAS

(Irwin et al., 2020)

is ameliorated by bsk^DN.UAS

(Irwin et al., 2020)

is exacerbated by hep^Act.UAS.cUa

(Irwin et al., 2020)

is exacerbated by hpo^UAS.cUa

(Irwin et al., 2020)

is ameliorated by hpo^RNAi.UAS.cPa

(Irwin et al., 2020)

is ameliorated by puc^UAS.cMa

(Irwin et al., 2020)

is ameliorated by wts^TRiP.cUa

(Irwin et al., 2020)

is exacerbated by wts^UAS.cUa

(Irwin et al., 2020)

is exacerbated by SARS-CoV-2\nsp3^UAS.Tag:HA

(Singh et al., 2024)

is exacerbated by Hsap\TMEM59^UAS.cLa

(Li et al., 2021)

is ameliorated by Hsap\ORAI1^LOCa3.UAS

(He et al., 2021)

is ameliorated by Akt^RNAi.UAS.cUa

(Cheng et al., 2021)

is exacerbated by Egfr^UAS.cUa

(Cheng et al., 2021)

is ameliorated by Pi3K21B^UAS.Tag:HA

(Cheng et al., 2021)

is exacerbated by Pi3K92E^UAS.Tag:MYC

(Cheng et al., 2021)

is ameliorated by Rac1^DN.UAS.cUa

(Cheng et al., 2021)

is ameliorated by Ras85D^DN.UAS.cUa

(Cheng et al., 2021)

is exacerbated by Ras85D^V12.UAS

(Cheng et al., 2021)

is ameliorated by foxo^UAS.cUa

(Cheng et al., 2021)

is ameliorated by CalpB^VSH330155

(Huang et al., 2024)

is ameliorated by kn^KK114322

(Huang et al., 2024)

is ameliorated by mir-282^UAS.cVa

(Huang et al., 2024)

is ameliorated by sca^KK106319

(Huang et al., 2024)

is exacerbated by Amy-d^HMC04878

(Upadhyay et al., 2023)

is ameliorated by CG13887^EY21004

(Upadhyay et al., 2023)

is exacerbated by CG13887^HMS00707

(Upadhyay et al., 2023)

is ameliorated by CG4009^HMS05350

(Upadhyay et al., 2023)

is ameliorated by Ide^EP3099

(Upadhyay et al., 2023)

is exacerbated by M6^HMS01645

(Upadhyay et al., 2023)

is ameliorated by Pez^HMS00861

(Upadhyay et al., 2023)

is ameliorated by Pgm2a^HMC04927

(Upadhyay et al., 2023)

is ameliorated by Spn55B^HMS02693

(Upadhyay et al., 2023)

is exacerbated by Vha100-5^HMJ30067

(Upadhyay et al., 2023)

is exacerbated by shot^HMJ23381

(Upadhyay et al., 2023)

exacerbates prion disease

modeled by Hsap\PRNP^V129.UAS.att

(Myers et al., 2022)

modeled by Hsap\PRNP^M129.UAS.att

(Myers et al., 2022)

model of neurodegenerative disease

is exacerbated by Jra^Asp.B.UAS

(Tare et al., 2011)

is ameliorated by puc^UAS.cMa

(Tare et al., 2011)

is ameliorated by bsk^DN.UAS

(Tare et al., 2011)

is exacerbated by hep^Act.UAS.cUa

(Tare et al., 2011)

is ameliorated by crb^{IntraΔERLI.UAS.Tag:MYC}

(Steffensmeier et al., 2013)

is ameliorated by crb^{IntraY10A.E16A.ΔERLI.UAS.Tag:MYC}

(Steffensmeier et al., 2013)

is ameliorated by crb^{IntraY10A.E16A.UAS.Tag:MYC}

(Steffensmeier et al., 2013)

is exacerbated by crb^UAS.cWa

(Steffensmeier et al., 2013)

is ameliorated by crb^GD14463

(Steffensmeier et al., 2013)

is ameliorated by crb^11A22

(Steffensmeier et al., 2013)

model of Alzheimer's disease

is ameliorated by nej^ΔQ.UAS

(Cutler et al., 2015)

is ameliorated by nej^ΔHQ.UAS

(Cutler et al., 2015)

is ameliorated by nej^ΔNZK.UAS

(Cutler et al., 2015)

is ameliorated by nej^KIX.UAS

(Cutler et al., 2015)

is exacerbated by nej^ΔBHQ.UAS

(Cutler et al., 2015)

is ameliorated by nej^UAS.Tag:V5

(Cutler et al., 2015)

is ameliorated by bsk¹

(Hong et al., 2012)

is ameliorated by foxo²¹

(Hong et al., 2012)

is ameliorated by foxo²⁵

(Hong et al., 2012)

is ameliorated by Diap1^UAS.cHa

(Hong et al., 2012)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.wt

(Panchal and Tiwari, 2020)

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.wt

(Panchal and Tiwari, 2020)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec).cBa}

model of Alzheimer's disease 1

is ameliorated by Hsap\MAPT^KI.hMAPT.4Q

(Gorsky et al., 2017)

is exacerbated by Hsap\MAPT^KI.hMAPT.4R

(Gorsky et al., 2017)

is ameliorated by Naglu^UAS.Tag:HA

(Xue et al., 2022)

Hsap\APP^UAS.cUa

model of Alzheimer's disease 1

is exacerbated by faf^EP381

(Lee et al., 2012)

Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease 1

is ameliorated by Droj2^MI08491

(Ring et al., 2022)

is ameliorated by faf^RNAi.UAS.cUa

(Lee et al., 2012)

is exacerbated by faf^EP381

(Lee et al., 2012)

is ameliorated by par-1^RNAi.UAS.cZa

(Lee et al., 2012)

is ameliorated by slmb^RNAi.UAS.cUa

(Lee et al., 2012)

is exacerbated by Rac1^HMS01258

(Kikuchi et al., 2020)

is exacerbated by Rac1^JF02813

(Kikuchi et al., 2020)

is ameliorated by Irp-1B^RNAi.UAS.cUa

(Ruland et al., 2018)

is exacerbated by Hsap\PTEN^C124S.UAS

(Chiang et al., 2010)

is ameliorated by Pi3K21B^GD9810

(Chiang et al., 2010)

is ameliorated by Pten^UAS.cGb

(Chiang et al., 2010)

is exacerbated by Vha68-1¹

(Wang et al., 2021)

is exacerbated by Vha68-1^GD16938

(Wang et al., 2021)

is exacerbated by Vha68-1^HMS02581

(Wang et al., 2021)

is exacerbated by Vha68-1^HMS02962

(Wang et al., 2021)

is ameliorated by nAChRα7^PΔEY6

(Hahm et al., 2018)

is ameliorated by tau^HMS02042

(Cheng et al., 2022)

is exacerbated by Cortactin^HMS00658

(Cheng et al., 2022)

is ameliorated by Cortactin^UAS.cSa

(Cheng et al., 2022)

is ameliorated by HDAC6^{H237A.H664A.UAS}

(Cheng et al., 2022)

is exacerbated by HDAC6^H237A.UAS

(Cheng et al., 2022)

is ameliorated by HDAC6^UAS.cDa

(Cheng et al., 2022)

is ameliorated by Shal^UAS.cPa

(Feng et al., 2018)

model of Alzheimer's disease

is ameliorated by CG17249^A362

(Belfiori-Carrasco et al., 2017)

is ameliorated by Hpd^KK105686

(Belfiori-Carrasco et al., 2017)

is ameliorated by Hpd^MI12465

(Belfiori-Carrasco et al., 2017)

is ameliorated by Atg1^Δ3D

(Ling et al., 2009)

is ameliorated by Atg5^RNAi.UAS

(Ling et al., 2009)

is exacerbated by sra^EY07182

(Lee et al., 2016)

is ameliorated by Ctr1C^RNAi.UAS.cLa

(Lang et al., 2013)

is ameliorated by Ctr1B^NIG.7459R

(Lang et al., 2013)

is ameliorated by ATP7^EY07895

(Lang et al., 2013)

is ameliorated by Zip42C.1^RNAi.UAS

(Lang et al., 2012)

is exacerbated by Zip42C.1^UAS.cLa

(Lang et al., 2012)

is ameliorated by Zip42C.1^GD1830

(Lang et al., 2012)

is ameliorated by Mmus\Fabp7^hs.PG

(Gerstner et al., 2017)

is ameliorated by fabp^hs.PG

(Gerstner et al., 2017)

is exacerbated by Hsap\TREM2^{13xlexAop.Tag:MYC,Tag:FLAG}

(Sekiya et al., 2018)

is exacerbated by Hsap\TREM2^{R47H.13xlexAop.Tag:MYC,Tag:FLAG}

(Sekiya et al., 2018)

is ameliorated by Tspo^EY00814

(Lin et al., 2014)

is ameliorated by Tspo^VDRC.cUa

(Lin et al., 2014)

is NOT ameliorated by fz2^{UAS.Tag:HA.GFP}

(Lüchtenborg and Katanaev, 2014)

is NOT ameliorated by sgg^GD1331

(Lüchtenborg and Katanaev, 2014)

is NOT ameliorated by Gαo^GTP.UAS

(Lüchtenborg and Katanaev, 2014)

is exacerbated by Hsap\MAPT^UAS.cWa

(Fulga et al., 2007)

is ameliorated by Hsap\MME^UAS.cIa

(Iijima-Ando et al., 2008)

exacerbates Alzheimer's disease

modeled by Hsap\MAPT^UAS.cWa

(Ando et al., 2016)

model of Parkinson's disease

is ameliorated by Pde4^dnc-1

(Iijima-Ando et al., 2009)

is exacerbated by Adcy1^rut-1

(Iijima-Ando et al., 2009)

is exacerbated by Miro^Sd32

(Iijima-Ando et al., 2009)

is exacerbated by milt^GD8116

(Iijima-Ando et al., 2009)

is exacerbated by Pka-C1^GD1276

(Iijima-Ando et al., 2009)

is ameliorated by Pka-R2^GD15709

(Iijima-Ando et al., 2009)

Hsap\APP^{3Q42.Aβ42.Tag:SS(rPENK)}

model of Alzheimer's disease 1

is ameliorated by Nep2^EP3549

(Sofola-Adesakin et al., 2016)

Hsap\APP^{Arctic.Aβ42.lexAop.Tag:SS(nec)}

model of Alzheimer's disease 1

is ameliorated by AttA^{UAS.APEX2,Tag:HA}

(Hsieh and Chiang, 2023)

is ameliorated by Cat^UAS.cUa

(Hsieh and Chiang, 2023)

is ameliorated by DptA^{UAS.ORF.GW.Tag:HA}

(Hsieh and Chiang, 2023)

is ameliorated by Sod1^UAS.cUa

(Hsieh and Chiang, 2023)

Hsap\APP^Aβ42.lexAop

model of Alzheimer's disease 1

is ameliorated by Sod1^RNAi.UAS.cHa

(Stapper and Jahn, 2018)

is ameliorated by Sod2^RNAi.UAS.cKa

(Stapper and Jahn, 2018)

is ameliorated by cnc^HMS02021

(Stapper and Jahn, 2018)

is ameliorated by cnc^JF02006

(Stapper and Jahn, 2018)

is ameliorated by Cat^GL01541

(Stapper and Jahn, 2018)

is ameliorated by Gclc^KK101607

(Stapper and Jahn, 2018)

is exacerbated by Gclc^UAS.cOa

(Stapper and Jahn, 2018)

Hsap\APP^{Aβ42.QUAS.Tag:SS(nec)}

model of Alzheimer's disease 1

is ameliorated by BacA\p35^UAS.cHa

(Sheng et al., 2023)

is ameliorated by Rel^GD1199

(Li et al., 2018)

is ameliorated by Rel^HMS00070

(Li et al., 2018)

Hsap\APP^{1-42.UAS.CRY2(PHR),mCherry}

model of Alzheimer's disease 1

is ameliorated by wg^{UAS.cHa.Tag:HA}

(Kaur et al., 2022)

Hsap\APP^{Aβ40.20xUAS.Tag:SS(nec)}

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Arctic.Aβ42.20xUAS.Tag:SS(nec)}

(Sowade and Jahn, 2017)

Hsap\APP^{Arctic.Aβ42.20xUAS.Tag:SS(nec)}

model of Alzheimer's disease 1

is ameliorated by Hsap\APP^{Aβ40.20xUAS.Tag:SS(nec)}

(Sowade and Jahn, 2017)

Hsap\APP^{Aβ42.UAS.Tag:SS(aos)}

model of Alzheimer's disease 1

is exacerbated by Hsap\APP^{Aβ42.E22G.UAS.Tag:SS(aos)}

(De Mena et al., 2020)

is exacerbated by Hsap\APP^{Aβ42.E22Q.UAS.Tag:SS(aos)}

(De Mena et al., 2020)

is exacerbated by Hsap\APP^{Aβ42.S26C.UAS.Tag:SS(aos)}

(De Mena et al., 2020)

Hsap\APP^{Aβ42.E22G.UAS.Tag:SS(aos)}

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(aos)}

(De Mena et al., 2020)

Hsap\APP^{Aβ42.E22Q.UAS.Tag:SS(aos)}

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(aos)}

(De Mena et al., 2020)

Hsap\APP^{Aβ42.S26C.UAS.Tag:SS(aos)}

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(aos)}

(De Mena et al., 2020)

Hsap\APP^{3-42.E3Q.UAS.Tag:SS(rPENK)}

model of Alzheimer's disease 1

is ameliorated by Atf6^c05057

(Tsuda et al., 2017)

is ameliorated by BacA\p35^UAS.cUa

(Tsuda et al., 2017)

is exacerbated by Hsap\MAPT^{UAS.2N4R.cSMa}

(Tsuda et al., 2017)

is ameliorated by Ire1^f02170

(Tsuda et al., 2017)

is ameliorated by Xbp1^k13803

(Tsuda et al., 2017)

is ameliorated by crc¹

(Tsuda et al., 2017)

exacerbates tauopathy

modeled by Hsap\MAPT^{UAS.2N4R.cSMa}

(Tsuda et al., 2017)

Hsap\APP^{C99.V717I.UAS}

model of Alzheimer's disease 1

is ameliorated by Acer^Δ168

(Lee et al., 2020)

Hsap\APP^{Arctic.Aβ42.UAS.cUa}

model of Alzheimer's disease 1

is exacerbated by Hsap\MAPT^R406W.UAS

(Sun et al., 2022)

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Sun et al., 2022)

Hsap\APP^UAS.cLa.EGFP

model of Alzheimer's disease 1

is exacerbated by Rack1^{UAS.ORF.Tag:HA}

(Li et al., 2024)

is ameliorated by Clbn^HMJ23825

(Li et al., 2024)

is exacerbated by Ire1^GD3071

(Li et al., 2024)

is exacerbated by Ire1^HMC05163

(Li et al., 2024)

is ameliorated by Ire1^UAS.Tag:V5

(Li et al., 2024)

is ameliorated by Rack1^HMS01173

(Li et al., 2024)

Hsap\APP^{Δ41-50.UAS.EGFP}

model of Alzheimer's disease 1

is ameliorated by Rack1^HMS01173

(Li et al., 2024)

is ameliorated by Ire1^UAS.Tag:V5

(Li et al., 2024)

is exacerbated by Rack1^{UAS.ORF.Tag:HA}

(Li et al., 2024)

is ameliorated by Clbn^HMJ23825

(Li et al., 2024)

is exacerbated by Ire1^GD3071

(Li et al., 2024)

is exacerbated by Ire1^HMC05163

(Li et al., 2024)

Hsap\APP^695.QUAS

model of Alzheimer's disease 1

is ameliorated by atl^UAS.cMa

(Mou et al., 2024)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

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(data from AllianceMine provided by esyN)

Select Layout:

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Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hsap\APP - Droj2

anti bait coimmunoprecipitation, western blot

(Ring et al., 2022)

Hsap\APP - Edem1

anti tag coimmunoprecipitation, western blot

(Sekiya et al., 2017)

Hsap\APP - Edem2

anti tag coimmunoprecipitation, western blot

(Sekiya et al., 2017)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0025823

Class of Gene

engineered_foreign_gene

Stocks and Reagents

Stocks (81)

Bloomington

83347

w¹¹¹⁸; P{QUAS-Aβ42.L}4

83348

w¹¹¹⁸; P{QUAS-Aβ42.L}7

32038

P{UAS-Abeta1-42.G}1, w^*

64384

w^*; P{UAS-hAPP.Z}attP40

30119

w¹¹¹⁸; P{UAS-mycAPP.LV}2

64385

w^*; P{UAS-hAPP.HA}attP40

90961

w¹¹¹⁸; P{UAS-Aβ40.B}attP2

90962

w¹¹¹⁸; P{UAS-Aβ42.B}attP2

90963

w¹¹¹⁸; P{UAS-Aβ43.B}attP2

6700

w^*; P{UAS-APP695-N-myc}TW6

83346

w¹¹¹⁸; P{QUAS-Aβ40.L}6/CyO

90957

w¹¹¹⁸; P{UAS-Aβ40.B}attP40

More stocks available...

Other Comments

Expression of Hsap\APP in Drosophila induces AICD-dependent cell death and a locomotion defect.

(Wang et al., 2014)

Expression of Hsap\APP is able to induce cell death in non-neuronal tissues during development.

(Wang et al., 2014)

The ability of Xbp1 overepxression and loss-of-function alleles to modify Hsap\APP neurotoxicity in the eye suggests that Xbp1 plays a key role in Hsap\APP pathobiology.

(Casas-Tinto et al., 2011)

Expression of Mmus\Xbp1 reduces Hsap\APP neurotoxicity without altering Aβ levels and aggregation.

(Casas-Tinto et al., 2011)

Relationship to Other Genes

Source for database merge of

Additional comments

FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012).

(FlyBase Curators, 1992-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (47)

Reported As

Symbol Synonym

695

(Gunawardena and Goldstein, 2001)

AD1

(HGNC Curators and FlyBase Curators, 2013-)

APP

(Bongiorni et al., 2024, Dos Santos et al., 2024, Inthachat et al., 2024, Kongsung et al., 2024, Bhatnagar et al., 2023, Hao et al., 2023, Zhuang et al., 2023, Chauhan et al., 2022, Chiang et al., 2022, Malta et al., 2022, Wang et al., 2022, Cacabelos et al., 2021, Du et al., 2021, Jalali et al., 2021, Kitani-Morii et al., 2021, Kong et al., 2021, Moyer et al., 2021, Neuman et al., 2021, Rimal et al., 2021, Walsh et al., 2021, Bolus et al., 2020, Denton et al., 2020, Jeon et al., 2020, Kim et al., 2020, Li et al., 2020, Vajente et al., 2020, Zhuang et al., 2020, Chen et al., 2019, Deshpande et al., 2019, Huichalaf et al., 2019, Mórotz et al., 2019, Sivanantharajah et al., 2019, Westfall et al., 2019, Moore et al., 2018, Dissel et al., 2017, Saburova et al., 2017, Siddique and Ali, 2017, Wang et al., 2016, Xu et al., 2016, Cutler et al., 2015, Fernandez-Funez et al., 2015, Lee et al., 2015, Peng et al., 2015, Xu and Elefant, 2015, Hou et al., 2014, Hu et al., 2014, Kang et al., 2014, Mhatre et al., 2014, Mhatre et al., 2014, Park et al., 2014, Sofola-Adesakin et al., 2014, Vorobyeva et al., 2014, Wang et al., 2014, Wang et al., 2014, Xu et al., 2014, Gross et al., 2013, HGNC Curators and FlyBase Curators, 2013-, Hopkins, 2013, Johnson et al., 2013, Moran et al., 2013, Pirooznia et al., 2012, Reis et al., 2012, Singh and Mlodzik, 2012, Wentzell et al., 2012, Zuo et al., 2012, Casas-Tinto et al., 2011, Chakraborty et al., 2011, Copenhaver et al., 2011, Goguel et al., 2011, Kim et al., 2011, Singh and Mahoney, 2011.2.17, Iijima-Ando and Iijima, 2010, Lloyd and Taylor, 2010, Merdes, 2010.2.24, Merdes, 2010.8.5, Stempfle et al., 2010, Tsuda et al., 2010, Wang et al., 2010, Iijima-Ando et al., 2009, Sarantseva et al., 2009, Gross et al., 2008, Iijima et al., 2008, Muhammad et al., 2008, Isoo et al., 2007, Li et al., 2007, Wang et al., 2007, Weaver et al., 2007, Crowther et al., 2005, Finelli et al., 2004, Greeve et al., 2004, Loewer et al., 2004, Loewer et al., 2004, Lanoue et al., 2000, Yagi et al., 2000)

APP695

(Vivien Chiu et al., 2017, Gunawardena and Goldstein, 2001)

APP₆₉₅

(Cassar and Kretzschmar, 2016)

Ab42

(Iijima et al., 2007)

Abeta

(Wang et al., 2020, Goldstein, 2010.10.12, Cao et al., 2007, Konsolaki et al., 2006, Kelkar et al., 2005)

Abeta42

(Siddique et al., 2022, Siddique et al., 2022, Tower et al., 2019, Li et al., 2018, Sofola et al., 2010)

Alz

(Rival et al., 2009, Crowther et al., 2005)

App

(Lopez-Arias et al., 2017, Mohaibes et al., 2017, Zografos et al., 2016)

Arctic Aβ₄₂

(Kong et al., 2016)

Aβ

(Kumar et al., 2024, Li et al., 2024, Belfer et al., 2021, Park et al., 2021, Wang and Westermark, 2021, Solomatina et al., 2020, Tue et al., 2020, Beg et al., 2018, Pavlov et al., 2018, Stapper and Jahn, 2018, Sun et al., 2018, Singh et al., 2017, Cassar and Kretzschmar, 2016, Minjarez et al., 2016, Burnouf et al., 2015, Jonson et al., 2015, Kang et al., 2015, Tabuchi et al., 2015, Acerra et al., 2014, Allan et al., 2014, Chen et al., 2014, Ling et al., 2014, Long et al., 2014, Lüchtenborg and Katanaev, 2014, McKoy et al., 2014, Omata et al., 2014, Singh et al., 2014, Favrin et al., 2013, Singh et al., 2013, Caesar et al., 2012, Scherzer-Attali et al., 2012, Speretta et al., 2012, Ambegaokar and Jackson, 2011, Diangelo et al., 2011, Frydman-Marom et al., 2011, Hua et al., 2011, Jahn et al., 2011, Kumar et al., 2011, Liu et al., 2011, Folwell et al., 2010, Luheshi et al., 2010, Moloney et al., 2010, Sofola et al., 2010, Tsuda et al., 2010, Nerelius et al., 2009, Rival et al., 2009, Schilling et al., 2008, Luheshi et al., 2007, Kinghorn et al., 2006, Crowther et al., 2005)

Aβ-42

(Lim et al., 2021, Shaposhnikov et al., 2020, Papanikolopoulou et al., 2019)

Aβ1-42

(Elovsson et al., 2021, Sandin et al., 2016)

Aβ42

(Dai et al., 2024, Go et al., 2024, Li et al., 2024, Singh et al., 2024, Costa et al., 2023, Kiran et al., 2023, Oyarce-Pezoa et al., 2023, Tan et al., 2023, Tuo et al., 2023, Wu et al., 2023, Yang et al., 2023, Yang et al., 2023, Yeates et al., 2023, Yin et al., 2023, Anupama et al., 2022, Chauhan et al., 2022, Deolankar et al., 2022, Goodman and Bellen, 2022, Himalian et al., 2022, Ishola et al., 2022, Liu et al., 2022, Tello et al., 2022, Costa-Rodrigues et al., 2021, Gogia et al., 2021, Ishola et al., 2021, Kong et al., 2021, Millet-Boureima et al., 2021, Rahul and Siddique, 2021, Yu and Hyun, 2021, Abtahi et al., 2020, Ahmed et al., 2020, Arnés et al., 2020, Garrido-Maraver et al., 2020, Halim et al., 2020, Miller et al., 2020, Ali et al., 2019, Chen et al., 2019, Huang et al., 2019, Hwang et al., 2019, Taylor and Tuxworth, 2019, Chai et al., 2018, Coelho et al., 2018, Ji et al., 2018, Kong et al., 2018, Li et al., 2018, Liu et al., 2018, Sarkar et al., 2018, Sekiya et al., 2018, Sun et al., 2018, Yamasaki et al., 2018, Yeh et al., 2018, Arnés et al., 2017, Belfiori-Carrasco et al., 2017, Berlandi et al., 2017, Jeon et al., 2017, Kerr et al., 2017, Lv et al., 2017, Marcora et al., 2017, Ray et al., 2017, Song et al., 2017, Liu et al., 2016, Sarkar et al., 2016, Shen et al., 2016, Lee et al., 2015, Nevzglyadova et al., 2015, Zhao et al., 2015, Marcora et al., 2014, Chapuis et al., 2013, Lenz et al., 2013, Prüßing et al., 2013, Zuo et al., 2013, Lang et al., 2012, Rogers et al., 2012, Hong et al., 2011, Lee et al., 2011, Chiang et al., 2010, Iijima et al., 2010, Chiang et al., 2009)

Aβ42arc

(Canal-Martín et al., 2019)

AβPP

(Bergkvist et al., 2020, Miguel et al., 2020, Bergkvist et al., 2016, Sandin et al., 2016, Bouleau and Tricoire, 2015, Khanna and Fortini, 2015, Wang et al., 2015)

AβQ3-42

(Sofola-Adesakin et al., 2016)

HAPP

(Cheng et al., 2020)

Hsap\APP

(Singh et al., 2024, Temviriyanukul et al., 2022, Bhattacharjee et al., 2019, Coelho and Moreno, 2019, Breda et al., 2016)

alpha-sAPP

(HGNC Curators and FlyBase Curators, 2013-)

amyloid-Β 42

(Iijima-Ando et al., 2010)

amyloid-β

(Fang et al., 2012)

h-APP

(Daubert et al., 2010)

hAPP

(Hendricks et al., 2024, Megaly et al., 2024, Vecchie' et al., 2024, Ghalayini and Boulianne, 2023, Jiang and MacNeil, 2023, Chakrabarty et al., 2022, Carregosa et al., 2021, Tsakiri et al., 2017, Xu et al., 2014, Gunawardena et al., 2013, Brusch and Goldstein, 2003)

hApp

(Hoe et al., 2011)

human APP

(Beaver et al., 2022)

Αβ42

(Wang et al., 2012)

β-APP

(Struhl and Adachi, 2000)

βAPP

(Takasugi et al., 2002)

Name Synonyms

Alzheimer disease

(HGNC Curators and FlyBase Curators, 2013-)

Amyloid beta A4 precursor protein

Amyloid β

(Jonson et al., 2015)

amyloid beta (A4) precursor protein

(HGNC Curators and FlyBase Curators, 2013-)

amyloid beta precursor protein

(HGNC Curators and FlyBase Curators, 2013-)

amyloid precursor protein

(Wang et al., 2015, Park et al., 2014, Hoe et al., 2011, Lloyd and Taylor, 2010, Iijima et al., 2008, Finelli et al., 2004)

amyloid β

(Singh et al., 2013)

amyloid-beta

(McKoy et al., 2014)

amyloid-beta (Aβ) peptide

(Luheshi et al., 2010)

amyloid-beta 42

(Sarkar et al., 2016)

amyloid-β

(Sowade and Jahn, 2017, Nerelius et al., 2009)

amyloid-β peptide

(Luheshi et al., 2010)

amyloid-β protein

(Hua et al., 2011)

human Abeta

(Ma et al., 2017)

human amyloid precursor protein

(Gross et al., 2013, Loewer et al., 2004)

peptidase nexin-II

(HGNC Curators and FlyBase Curators, 2013-)

β-Amyloid

(Jonson et al., 2015)

β-amyloid

(Rival et al., 2009)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 8 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

Other crossreferences

Ensembl_Homo_sapiens -

ENSG00000142192

HUGO Gene Nomenclature Committee -

APP; amyloid beta precursor protein

MARRVEL - MARRVEL (human gene)

OMIM_GENE - Online Mendelian Inheritance in Man (Genes)

104760

OMIM_PHENOTYPE - Online Mendelian Inheritance in Man (Phenotypes)

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0025823

References (515)

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