Home
Gene Hsap\APP
| General Information | ||||||||
|---|---|---|---|---|---|---|---|---|
| Symbol | Hsap\APP | Species | H. sapiens | |||||
| Name | amyloid beta (A4) precursor protein | Annotation symbol | ||||||
| Feature type | engineered_foreign_gene | FlyBase ID | FBgn0025823 | |||||
| Gene Model Status | Not Applicable | Stock availability | 60 publicly available | |||||
| Also Known As | APP, Aβ, Aβ42, Abeta, hAPP, Alz | |||||||
| Genomic Location | ||||||||
| Chromosome (arm) | Recombination map | |||||||
| Cytogenetic map | Sequence location | |||||||
 Summary Information | ||||||||
| Automatically generated summary
See sections below for more information | The gene amyloid beta (A4) precursor protein is referred to in FlyBase by the symbol Hsap\APP (FBgn0025823). It is a engineered_foreign_gene from Homo sapiens. Its molecular function is unknown. The biological processes in which it is involved are not known. 100 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; external compound sense organ; adult; adult segment; sense organ; peripheral nervous system; cytoplasmic part; multicellular structure; organelle. It has no annotated transcripts. Gene has not been localized to the genome sequence. | |||||||
|
Recent Updates
|
||||||||
| Description |
What does this section display?
This section contains items that were added to this record for each release.
It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
|
|||||||
| Update Feed |
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your
feed reader.
|
|||||||
| FB2013_03 | ||||||||
| FB2013_02 | ||||||||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | |||||||
| Detailed Mapping Data | ||||||||
| FlyBase Computed Cytological Location | ||||||||
Cytogenetic map Evidence for location | ||||||||
| Experimentally Determined Cytological Location | ||||||||
Cytogenetic map Notes References | ||||||||
| Experimentally Determined Recombination Data | ||||||||
| Location | ||||||||
| Left of (cM) | ||||||||
| Right of (cM) | ||||||||
| Notes | ||||||||
| Gene Model & Products | ||||||||
| Comments on Gene Model | ||||||||
| Transcript Data | ||||||||
| Annotated Transcripts | ||||||||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS
(aa) | ||||||||
| Additional Transcript Data & Comments | ||||||||
| Reported size (kB) | ||||||||
| Comments | ||||||||
| External Data | ||||||||
| Crossreferences | ||||||||
|
Polypeptide Data | ||||||||
| Annotated Polypeptides | ||||||||
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein | ||||||||
| Additional Polypeptide Data & Comments | ||||||||
| Reported size (kDa) | ||||||||
| Comments | ||||||||
| External Data | ||||||||
| Linkouts | ||||||||
| Crossreferences | ||||||||
| Sequences Consistent with the Gene Model
| ||||||||
| DDBJ / EMBL / GenBank | DNA sequence Protein
sequence Name | |||||||
| UniProtKB/Swiss-Prot | ||||||||
| UniProtKB/TrEMBL | ||||||||
| Mapped Features | ||||||||
Type Symbol &
Location Additional Notes References | ||||||||
| External Data | ||||||||
| Linkouts | ||||||||
| Crossreferences | ||||||||
| Expression Data | ||||||||
| Transcript Expression | ||||||||
| Additional Descriptive Data | ||||||||
| Marker for | ||||||||
| Subcellular Localization | ||||||||
| CV Term | ||||||||
| Polypeptide Expression | ||||||||
| Additional Descriptive Data | ||||||||
| Marker for | ||||||||
| Subcellular Localization (GO Cellular Component) | ||||||||
CV term References | ||||||||
| Expression Deduced from Reporters | ||||||||
|
High-Throughput Expression Data
| ||||||||
| Associated Tools | ||||||||
| Reference |
See Gelbart and Emmert, 2010.10.13
for analysis details and data files for all genes.
| |||||||
|
FlyAtlas Anatomy Microarray
| ||||||||
|
modENCODE Anatomy RNA-Seq
| ||||||||
|
modENCODE Development RNA-Seq
| ||||||||
|
modENCODE Cell Lines RNA-Seq
| ||||||||
|
modENCODE Treatments RNA-Seq
| ||||||||
|
Expression Clusters
| ||||||||
|
External Data & Images
| ||||||||
| Linkouts | ||||||||
| Alleles & Phenotypes | ||||||||
| Summary of Allele Phenotypes | ||||||||
Lethality Allele Other Phenotypes Allele
visible, with Scer\GAL4GMR.PF Phenotype manifest
in Allele eye, with Scer\GAL4GMR.PF neuron, with Scer\GAL4elav-C155 neuropil, with Scer\GAL4elav-C155 neuropil, with Scer\GAL4ey-OK107 ventral adult lateral neuron & axon, with Scer\GAL4P2.4.Pdf | ||||||||
| Classical Alleles ( 0 ) | ||||||||
| For All Classical Alleles Show | ||||||||
| ||||||||
| Alleles Carried on Transgenic Constructs
( 100 ) | ||||||||
| For All Alleles Carried on Transgenic Constructs Show | ||||||||
| Aneuploid Aberrations | ||||||||
| Transgenic Constructs & Insertions
| ||||||||
| Transgenic Constructs | ||||||||
Type of
construct Name Expression
data | ||||||||
| Insertions | ||||||||
Type of insertions Name Expression
data | ||||||||
| Gene Ontology: Function, Process
& Cellular Component ( 0 unique terms ) | ||||||||
| Terms Based on
Experimental Evidence ( 0 terms ) | ||||||||
| Terms Based on Predictions or
Assertions ( 0 terms ) | ||||||||
| Sequence Ontology: Class of Gene | ||||||||
| Interactions & Pathways | ||||||||
|
Summary of Physical Interactions
| ||||||||
| Summary of Genetic Interactions | ||||||||
| Interacts with | Please look at the allele data
for full details of the genetic interactions Hsap\APP allele Gene References | |||||||
| External Data | ||||||||
| Linkouts | DroID
- A comprehensive database of gene and protein interactions.
| |||||||
| Orthologs
| ||||||||
|
OrthoDB Orthologs (0)
- based on analysis using Dmel annotation version 5.41
| ||||||||
| OrthoDB Ortholog Groups | ||||||||
OrthoDB orthology group searches Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified | ||||||||
| Ortholog(s) in Drosophila melanogaster (None identified) | ||||||||
No D. melanogaster orthologies identified | ||||||||
| Human Orthologs (0) | ||||||||
Gene OMIM HGNC | ||||||||
| AAA Orthologs (0)
based on analysis using Dmel annotation version 4.3
| ||||||||
No orthologs identified
| ||||||||
| Stocks & Reagents | ||||||||
| Stocks Listed in FlyBase ( 60 ) | ||||||||
| Bloomington | ||||||||
| Genomic Clones ( 0 ) | ||||||||
| cDNA Clones ( 0 ) | ||||||||
| cDNA Clones, Fully Sequenced | ||||||||
| BDGP DGC clones | ||||||||
| Other clones | ||||||||
| cDNA Clones, End Sequenced (ESTs) | ||||||||
| BDGP DGC clones | ||||||||
| Other clones | ||||||||
| RNAi & Array Information | ||||||||
| Linkouts | ||||||||
|
Antibody Information
| ||||||||
| Other Information | ||||||||
| Discoverer | ||||||||
| Etymology | ||||||||
| Identification | ||||||||
| Relationship to Other Genes | ||||||||
| Source for database identity of | ||||||||
| Source for database merge of | ||||||||
| Additional comments | FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012). | |||||||
| Other Comments | ||||||||
| Tag or Foreign
Gene Data | ||||||||
| ||||||||
| External Crossreferences & Linkouts
| ||||||||
| Sequence Crossreferences | ||||||||
| Other Crossreferences | ||||||||
HGNC | ||||||||
| Linkouts | ||||||||
DroID
- A comprehensive database of gene and protein interactions.
| ||||||||
| Synonyms & Secondary IDs
( 25 ) | ||||||||
| Reported As | ||||||||
| Symbol Synonym | Ab42 Abeta42 amyloid-Β 42 APP (Lanoue et al., 2000, Isoo et al., 2007, Weaver et al., 2007, Greeve et al., 2004, Copenhaver et al., 2011, Muhammad et al., 2008, Wang et al., 2007, Li et al., 2007, Loewer et al., 2004, Loewer et al., 2004, Merdes, 2010.2.24, Iijima-Ando et al., 2009, Iijima et al., 2008, Wentzell et al., 2012, Merdes, 2010.8.5, Finelli et al., 2004, Crowther et al., 2005, Singh and Mahoney, 2011.2.17, Goguel et al., 2011, Wang et al., 2010, Kim et al., 2011, Chakraborty et al., 2011, Tsuda et al., 2010, Reis et al., 2012, Singh and Mlodzik, 2012) APP695 Aβ (Kinghorn et al., 2006, Kumar et al., 2011, Nerelius et al., 2009, Diangelo et al., 2011, Crowther et al., 2005, Rival et al., 2009, Luheshi et al., 2007, Liu et al., 2011, Hua et al., 2011, Luheshi et al., 2010, Tsuda et al., 2010, Schilling et al., 2008, Frydman-Marom et al., 2011, Scherzer-Attali et al., 2012, Speretta et al., 2012, Caesar et al., 2012) Aβ42 Aβ42 hApp Hsap\APP βAPP β-APP | |||||||
| Name Synonym | amyloid beta (A4) precursor protein amyloid-beta (Aβ) peptide Amyloid beta A4 precursor protein amyloid precursor protein amyloid-β amyloid-β peptide amyloid-β protein human amyloid precursor protein β-amyloid | |||||||
| Secondary FlyBase IDs | ||||||||
| References ( 88 ) | ||||||||
| Generate a list of | ||||||||
| List References by type |
| |||||||
|
Recent research papers ( 22 ) | ||||||||
| ||||||||
|
Recent reviews (0)
| ||||||||
| All reviews listed in FlyBase were published before 2011 | ||||||||