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Gene Dmel\Hdac3

General Information
Symbol	Dmel\Hdac3	Species	D. melanogaster
Name	Histone deacetylase 3	Annotation symbol	CG2128
Feature type	protein_coding_gene	FlyBase ID	FBgn0025825
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	dHDAC3, HDAC
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83A4-83A4	Sequence location	3R:1,298,532..1,300,322 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Histone deacetylase 3 is referred to in FlyBase by the symbol Dmel\Hdac3 (CG2128, FBgn0025825). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; histone deacetylase activity. There is experimental evidence that it is involved in the biological process: regulation of transcription, DNA-dependent; negative regulation of apoptotic process; chromatin silencing. 15 alleles are reported. The phenotype of these alleles is annotated with: wing. It has one annotated transcript and one annotated polypeptide. Protein features are: Histone deacetylase; Histone deacetylase domain; Histone deacetylase superfamily. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1637369_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Hdac3. Gene sequence location is 3R:1298532..1300322.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83A4-83A4   Limits computationally determined from genome sequence between P{PZ}Snr101319&P{PZ}Itp-r83A05616 and P{lacW}Atus1938
Experimentally Determined Cytological Location
Cytogenetic map Notes References 83A3-83A4     (Johnson, 1998.6.11) 83A3-83A4   (determined by in situ hybridisation)   (Johnson et al., 1998)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hdac3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	5' UTR contains an ORF described as a putative conserved uORF (FBrf0204849) Gene model reviewed during 5.49 5' UTR contains an ORF that is conserved among close Drosophila species (potential peptide 38 aa in length).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hdac3-RA FBtr0078767  NM_143721   1660   438
Additional Transcript Data & Comments
Reported size (kB)	1.746 (longest cDNA) (Johnson et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hdac3-PA   FBpp0078414   49.6   438   5.07     NP_651978   AAF52023
Additional Polypeptide Data & Comments
Reported size (kDa)	438 (aa) (Johnson et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Histone deacetylase superfamily (IPR000286) Histone deacetylase (IPR003084) Histone deacetylase domain (IPR023801)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140855   AA816257   AA820237   AE014297 AAF52023   AF071559 AAC83649   AI257538   AI455365   AI455941   AI456902   AI513368   AI514991   AI515017   AI516228   AY061321 AAL28869   BF502079   BI214595   BI234369   BI632873   BI633804   BX029656   BX053459   CK604885   CK657284   CO278442   CO327567   DN154170   EC198682   EC200813   EC256973
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KTS4 Q9VNC2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Zhu et al., 2008) embryonic/larval central nervous system   (Zhu et al., 2008) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012) larval stage   embryonic/larval central nervous system   (Zhu et al., 2008) embryonic/larval brain   (Zhu et al., 2008) wing disc   (Zhu et al., 2008) adult stage | female   ovariole   (Zhu et al., 2008)
Additional Descriptive Data
	Rpd3 transcripts are more abundant during development than Hdac3 transcripts. (Zhu et al., 2008)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Cho et al., 2005) nucleus inferred from direct assay (Cho et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    363.025 Larval Midgut    133.8 Larval Hindgut    161.3 Larval Malpighian Tubules    120.4 Larval Fat Body    94.3 Larval Salivary Gland    189.4 Larval Trachea    193.25 Larval Carcass    140.625 Adult Head    109.6 Adult Eye    144.4 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    159 Adult Crop    146.7 Adult Midgut    101.1 Adult Hindgut    106.8 Adult Malpighian Tubules    100.9 Adult Fat Body    74.8 Adult Salivary Gland    92.8 Adult Heart    60.4 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    60.9 Adult Ovary    229.9 Adult Testis    81.7 Adult Male Accessory Gland    127.9 Adult Carcass    90.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    363.025 Larval Midgut    133.8 Larval Hindgut    161.3 Larval Malpighian Tubules    120.4 Larval Fat Body    94.3 Larval Salivary Gland    189.4 Larval Trachea    193.25 Larval Carcass    140.625 Adult Head    109.6 Adult Eye    144.4 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    159 Adult Crop    146.7 Adult Midgut    101.1 Adult Hindgut    106.8 Adult Malpighian Tubules    100.9 Adult Fat Body    74.8 Adult Salivary Gland    92.8 Adult Heart    60.4 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    60.9 Adult Ovary    229.9 Adult Testis    81.7 Adult Male Accessory Gland    127.9 Adult Carcass    90.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    363.025 Larval Midgut    133.8 Larval Hindgut    161.3 Larval Malpighian Tubules    120.4 Larval Fat Body    94.3 Larval Salivary Gland    189.4 Larval Trachea    193.25 Larval Carcass    140.625 Adult Head    109.6 Adult Eye    144.4 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    159 Adult Crop    146.7 Adult Midgut    101.1 Adult Hindgut    106.8 Adult Malpighian Tubules    100.9 Adult Fat Body    74.8 Adult Salivary Gland    92.8 Adult Heart    60.4 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    60.9 Adult Ovary    229.9 Adult Testis    81.7 Adult Male Accessory Gland    127.9 Adult Carcass    90.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    363.025 Larval Midgut    133.8 Larval Hindgut    161.3 Larval Malpighian Tubules    120.4 Larval Fat Body    94.3 Larval Salivary Gland    189.4 Larval Trachea    193.25 Larval Carcass    140.625 Adult Head    109.6 Adult Eye    144.4 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    159 Adult Crop    146.7 Adult Midgut    101.1 Adult Hindgut    106.8 Adult Malpighian Tubules    100.9 Adult Fat Body    74.8 Adult Salivary Gland    92.8 Adult Heart    60.4 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    60.9 Adult Ovary    229.9 Adult Testis    81.7 Adult Male Accessory Gland    127.9 Adult Carcass    90.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    363.025 Larval Midgut    133.8 Larval Hindgut    161.3 Larval Malpighian Tubules    120.4 Larval Fat Body    94.3 Larval Salivary Gland    189.4 Larval Trachea    193.25 Larval Carcass    140.625 Adult Head    109.6 Adult Eye    144.4 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    159 Adult Crop    146.7 Adult Midgut    101.1 Adult Hindgut    106.8 Adult Malpighian Tubules    100.9 Adult Fat Body    74.8 Adult Salivary Gland    92.8 Adult Heart    60.4 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    60.9 Adult Ovary    229.9 Adult Testis    81.7 Adult Male Accessory Gland    127.9 Adult Carcass    90.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    363.025 Larval Midgut    133.8 Larval Hindgut    161.3 Larval Malpighian Tubules    120.4 Larval Fat Body    94.3 Larval Salivary Gland    189.4 Larval Trachea    193.25 Larval Carcass    140.625 Adult Head    109.6 Adult Eye    144.4 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    159 Adult Crop    146.7 Adult Midgut    101.1 Adult Hindgut    106.8 Adult Malpighian Tubules    100.9 Adult Fat Body    74.8 Adult Salivary Gland    92.8 Adult Heart    60.4 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    60.9 Adult Ovary    229.9 Adult Testis    81.7 Adult Male Accessory Gland    127.9 Adult Carcass    90.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    363.025 Larval Midgut    133.8 Larval Hindgut    161.3 Larval Malpighian Tubules    120.4 Larval Fat Body    94.3 Larval Salivary Gland    189.4 Larval Trachea    193.25 Larval Carcass    140.625 Adult Head    109.6 Adult Eye    144.4 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    159 Adult Crop    146.7 Adult Midgut    101.1 Adult Hindgut    106.8 Adult Malpighian Tubules    100.9 Adult Fat Body    74.8 Adult Salivary Gland    92.8 Adult Heart    60.4 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    60.9 Adult Ovary    229.9 Adult Testis    81.7 Adult Male Accessory Gland    127.9 Adult Carcass    90.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    363.025 Larval Midgut    133.8 Larval Hindgut    161.3 Larval Malpighian Tubules    120.4 Larval Fat Body    94.3 Larval Salivary Gland    189.4 Larval Trachea    193.25 Larval Carcass    140.625 Adult Head    109.6 Adult Eye    144.4 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    159 Adult Crop    146.7 Adult Midgut    101.1 Adult Hindgut    106.8 Adult Malpighian Tubules    100.9 Adult Fat Body    74.8 Adult Salivary Gland    92.8 Adult Heart    60.4 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    60.9 Adult Ovary    229.9 Adult Testis    81.7 Adult Male Accessory Gland    127.9 Adult Carcass    90.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    109.6   NA  Eye    144.4   NA  Brain    158.7   363.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    159   NA  Crop    146.7   133.8  Midgut    101.1   161.3  Hindgut    106.8   120.4  Malpighian Tubules    100.9   94.3  Fat Body    74.8   189.4  Salivary Gland    92.8   NA  Heart    60.4   193.25  Trachea    NA   NA  VirginFemale Spermatheca    64.9   NA  InseminatedFemale Spermatheca    60.9   NA  Ovary    229.9   NA  Testis    81.7   NA  Male Accessory Gland    127.9   140.625  Carcass    90.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    26 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    19 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    31 ovary, mated 4-day female    30 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3  26 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    19 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female  (31) ovary, mated 4-day female  (30) testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    26 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    19 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    31 ovary, mated 4-day female    30 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    26 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    19 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    31 ovary, mated 4-day female    30 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    26 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    19 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    31 ovary, mated 4-day female    30 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3  26 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    19 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female  31 ovary, mated 4-day female  30 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    26 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    19 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    31 ovary, mated 4-day female    30 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    26 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    19 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    31 ovary, mated 4-day female    30 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    70 embryo 04-06hr    28 embryo 06-08hr    42 embryo 08-10hr    45 embryo 10-12hr    37 embryo 12-14hr    24 embryo 14-16hr    30 embryo 16-18hr    21 embryo 18-20hr    12 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    20 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    23 white prepupae 12hr    28 white prepupae 24hr    32 pupae 2d postWPP    18 pupae 3d postWPP    11 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    13 adult male 30day    15 adult female 01day    25 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (54) embryo 02-04hr  (70) embryo 04-06hr  (28) embryo 06-08hr  (42) embryo 08-10hr  (45) embryo 10-12hr  (37) embryo 12-14hr    24 embryo 14-16hr  (30) embryo 16-18hr    21 embryo 18-20hr    12 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    20 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    23 white prepupae 12hr  (28) white prepupae 24hr  (32) pupae 2d postWPP    18 pupae 3d postWPP    11 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    13 adult male 30day    15 adult female 01day    25 adult female 05day  (28) adult female 30day  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    70 embryo 04-06hr    28 embryo 06-08hr    42 embryo 08-10hr    45 embryo 10-12hr    37 embryo 12-14hr    24 embryo 14-16hr    30 embryo 16-18hr    21 embryo 18-20hr    12 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    20 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    23 white prepupae 12hr    28 white prepupae 24hr    32 pupae 2d postWPP    18 pupae 3d postWPP    11 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    13 adult male 30day    15 adult female 01day    25 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    70 embryo 04-06hr    28 embryo 06-08hr    42 embryo 08-10hr    45 embryo 10-12hr    37 embryo 12-14hr    24 embryo 14-16hr    30 embryo 16-18hr    21 embryo 18-20hr    12 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    20 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    23 white prepupae 12hr    28 white prepupae 24hr    32 pupae 2d postWPP    18 pupae 3d postWPP    11 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    13 adult male 30day    15 adult female 01day    25 adult female 05day    28 adult female 30day    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    70 embryo 04-06hr    28 embryo 06-08hr    42 embryo 08-10hr    45 embryo 10-12hr    37 embryo 12-14hr    24 embryo 14-16hr    30 embryo 16-18hr    21 embryo 18-20hr    12 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    20 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    23 white prepupae 12hr    28 white prepupae 24hr    32 pupae 2d postWPP    18 pupae 3d postWPP    11 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    13 adult male 30day    15 adult female 01day    25 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (54) embryo 02-04hr  (70) embryo 04-06hr  28 embryo 06-08hr  (42) embryo 08-10hr  (45) embryo 10-12hr  (37) embryo 12-14hr    24 embryo 14-16hr  30 embryo 16-18hr    21 embryo 18-20hr    12 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    20 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    23 white prepupae 12hr  28 white prepupae 24hr  32 pupae 2d postWPP    18 pupae 3d postWPP    11 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    13 adult male 30day    15 adult female 01day    25 adult female 05day  28 adult female 30day  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    70 embryo 04-06hr    28 embryo 06-08hr    42 embryo 08-10hr    45 embryo 10-12hr    37 embryo 12-14hr    24 embryo 14-16hr    30 embryo 16-18hr    21 embryo 18-20hr    12 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    20 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    23 white prepupae 12hr    28 white prepupae 24hr    32 pupae 2d postWPP    18 pupae 3d postWPP    11 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    13 adult male 30day    15 adult female 01day    25 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    70 embryo 04-06hr    28 embryo 06-08hr    42 embryo 08-10hr    45 embryo 10-12hr    37 embryo 12-14hr    24 embryo 14-16hr    30 embryo 16-18hr    21 embryo 18-20hr    12 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    20 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    23 white prepupae 12hr    28 white prepupae 24hr    32 pupae 2d postWPP    18 pupae 3d postWPP    11 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    13 adult male 30day    15 adult female 01day    25 adult female 05day    28 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    32 embryonic 1182-4H    35 embryonic GM2    39 embryonic Kc167    33 embryonic S1    34 embryonic S3    28 leg disc CME L1    28 wing disc CME-W2    29 wing disc ML-DmD8    34 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    54 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    51 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    24 ovary fGS/OSS    34 ovary OSC    16 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (64) Schneider line 2 Sg4  (32) embryonic 1182-4H  (35) embryonic GM2  (39) embryonic Kc167  (33) embryonic S1  (34) embryonic S3  (28) leg disc CME L1  (28) wing disc CME-W2  (29) wing disc ML-DmD8  (34) wing disc ML-DmD9  (41) wing disc ML-DmD16-c3    25 wing disc ML-DmD21  (54) wing disc ML-DmD32  (41) haltere disc ML-DmD17-c3  (51) eye-antennal disc ML-DmD11  (28) antennal disc ML-DmD20-c5  (42) mixed discs ML-DmD4-c1  (33) CNS ML-DmBG1-c1  (39) CNS ML-DmBG2-c2  (33) tumorous blood cells mbn2    24 ovary fGS/OSS  (34) ovary OSC    16 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    32 embryonic 1182-4H    35 embryonic GM2    39 embryonic Kc167    33 embryonic S1    34 embryonic S3    28 leg disc CME L1    28 wing disc CME-W2    29 wing disc ML-DmD8    34 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    54 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    51 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    24 ovary fGS/OSS    34 ovary OSC    16 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    32 embryonic 1182-4H    35 embryonic GM2    39 embryonic Kc167    33 embryonic S1    34 embryonic S3    28 leg disc CME L1    28 wing disc CME-W2    29 wing disc ML-DmD8    34 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    54 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    51 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    24 ovary fGS/OSS    34 ovary OSC    16 ovary OSS    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    32 embryonic 1182-4H    35 embryonic GM2    39 embryonic Kc167    33 embryonic S1    34 embryonic S3    28 leg disc CME L1    28 wing disc CME-W2    29 wing disc ML-DmD8    34 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    54 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    51 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    24 ovary fGS/OSS    34 ovary OSC    16 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (64) Schneider line 2 Sg4  32 embryonic 1182-4H  (35) embryonic GM2  (39) embryonic Kc167  (33) embryonic S1  (34) embryonic S3  28 leg disc CME L1  28 wing disc CME-W2  29 wing disc ML-DmD8  (34) wing disc ML-DmD9  (41) wing disc ML-DmD16-c3    25 wing disc ML-DmD21  (54) wing disc ML-DmD32  (41) haltere disc ML-DmD17-c3  (51) eye-antennal disc ML-DmD11  28 antennal disc ML-DmD20-c5  (42) mixed discs ML-DmD4-c1  (33) CNS ML-DmBG1-c1  (39) CNS ML-DmBG2-c2  (33) tumorous blood cells mbn2    24 ovary fGS/OSS  (34) ovary OSC    16 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    32 embryonic 1182-4H    35 embryonic GM2    39 embryonic Kc167    33 embryonic S1    34 embryonic S3    28 leg disc CME L1    28 wing disc CME-W2    29 wing disc ML-DmD8    34 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    54 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    51 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    24 ovary fGS/OSS    34 ovary OSC    16 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    32 embryonic 1182-4H    35 embryonic GM2    39 embryonic Kc167    33 embryonic S1    34 embryonic S3    28 leg disc CME L1    28 wing disc CME-W2    29 wing disc ML-DmD8    34 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    54 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    51 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    24 ovary fGS/OSS    34 ovary OSC    16 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD23745 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025825 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2128-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage Hdac3N lethal | pupal stage, with Scer\GAL4pnr-MD237 Hdac3GD9732 Other Phenotypes Allele increased cell death | third instar larval stage (with Hdac3I) Hdac3J increased cell death | third instar larval stage (with Hdac3J) Hdac3I neuroanatomy defective | somatic clone Hdac3N visible | dominant Hdac3B Phenotype manifest in Allele imaginal disc | third instar larval stage Hdac36C imaginal disc | third instar larval stage (with Hdac3I) Hdac3J imaginal disc | third instar larval stage (with Hdac3J) Hdac3I projection neuron | somatic clone Hdac3N wing Hdac3B wing vein | ectopic Hdac3B
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Hdac3 Class Mutagen Stocks Known lesion Hdac36C P-element activity 1 Yes Hdac3N ethyl methanesulfonate 1 Yes Hdac3B ethyl methanesulfonate 0 Yes Hdac3I ethyl methanesulfonate 0 Yes Hdac3J ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hdac3 Class Mutagen Stocks Known lesion Hdac3GD16563 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hdac3GD9732 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hdac3HMS00087 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hdac3JF01420 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hdac3KK102732 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hdac3Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes Hdac3Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes Hdac3Act5C.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Hdac3Act5C.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Hdac3NIG.2128R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(3R)Hdac36C (Zhu et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9732} NA P{GD16563} NA P{KK102732} NA P{NIG.2128R} NA P{TRiP.HMS00087} NA P{TRiP.JF01420} NA P{UAS-Hdac3.3xFLAG} NA P{UAS-Hdac3.V5} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
histone deacetylase activity inferred from direct assay (Barlow et al., 2001, Cho et al., 2005) protein binding inferred from physical interaction with ebi (Qi et al., 2008) inferred from physical interaction with Smyd4 (Thompson and Travers, 2008)
Biological Process
CV term Evidence References
chromatin silencing inferred from genetic interaction with Rpd3 (Zhu et al., 2008) inferred from mutant phenotype (Zhu et al., 2008) negative regulation of apoptotic process inferred from mutant phenotype (Zhu et al., 2008) regulation of transcription, DNA-dependent inferred from direct assay (Cho et al., 2005)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Cho et al., 2005) nucleus inferred from direct assay (Cho et al., 2005)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
histone deacetylase activity inferred from sequence or structural similarity with EMBL:AF074881 (FlyBase, 1992-) non-traceable author statement (Johnson, 1998.6.11)
Biological Process
CV term Evidence References
histone deacetylation inferred from electronic annotation with InterPro:IPR003084 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Hdac3 - CG5525 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hdac3 - CG7033 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hdac3 - CG8258 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hdac3 - Cct5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hdac3 - Cctγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hdac3 - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hdac3 - Hsp27 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hdac3 - Smyd4 pull down, anti tag western blot, anti tag coimmunoprecipitation, autoradiography (Thompson and Travers, 2008) Hdac3 - Tcp-1ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hdac3 - Tcp-1η anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hdac3 - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hdac3 allele Gene References Hdac3B Snr1 (Zraly et al., 2004) Hdac3N Snr1 (Zraly et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69064 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025825 DroID - A comprehensive database of gene and protein interactions. • FBgn0025825 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44446
Orthologs
OrthoDB Orthologs (55) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6SBFHP Dipteran inclusive ortholog search EOG6Z62X0 Insect inclusive ortholog search EOG61RNQ9 Arthropod inclusive ortholog search EOG6N8PM3 Metazoa inclusive ortholog search EOG6RC3BZ
Orthologs in Drosophila Species (EOG6SBFHP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Hdac3     Drosophila simulans   Dsim\GD19615 Y   Drosophila sechellia   Dsec\GM10631 Y   Drosophila erecta   Dere\GG10995 Y   Drosophila yakuba   Dyak\GE25277 Y   Drosophila ananassae   Dana\GF17707 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA27397 Y   Drosophila persimilis   Dper\GL22163 Y   Drosophila willistoni   Dwil\GK11850 Y   Drosophila virilis   Dvir\GJ24563 Y   Drosophila mojavensis   Dmoj\GI24497 Y   Drosophila grimshawi   Dgri\GH18996 Y
Orthologs in non-Drosophila Dipterans (EOG6Z62X0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011117   Anopheles gambiae Malaria mosquito  Agam\AGAP001143   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013384
Orthologs in non-Dipteran Insects (EOG61RNQ9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Hdac3   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000106   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18647   Atta cephalotes Leafcutter ant  Acep\ACEP21152   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15828   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17598   Linepithema humile Argentine ant  Lhum\LH12836   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23785   Solenopsis invicta Red fire ant  Sinv\SINV11683   Acyrthosiphon pisum Pea aphid  Apim\ACYPI010047   Bombyx mori Silkmoth  Bmor\BGIBMGA013166   Pediculus humanus Human body louse  Phum\PHUM260560   Tribolium castaneum Red flour beetle  Tcas\TC006104
Orthologs in non-Insect Arthropods (EOG6N8PM3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\npy   Ixodes scapularis Deer tick  Isca\ISCW012528
Orthologs in non-Arthropod Metazoa (EOG6RC3BZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\hda-1 Y Caenorhabditis elegans Nematode  Cele\hda-3 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003879gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020148gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\HDAC1 Y Danio rerio Zebrafish  Drer\hdac1 Y Danio rerio Zebrafish  Drer\hdac3 Y Xenopus tropicalis Western clawed frog  Xtro\hdac2 Y Xenopus tropicalis Western clawed frog  Xtro\hdac3 Y Xenopus tropicalis Western clawed frog  Xtro\hdac1 Y Gallus gallus Domestic chicken  Ggal\HDAC1 Y Gallus gallus Domestic chicken  Ggal\HDAC2 Y Gallus gallus Domestic chicken  Ggal\HDAC3 Y Mus musculus House mouse  Mmus\ENSMUSG00000019777 Y Mus musculus House mouse  Mmus\Hdac3 Y Mus musculus House mouse  Mmus\Gm10093 Y Mus musculus House mouse  Mmus\Hdac1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000013695 Y Rattus norvegicus Norway rat  Rnor\Hdac3 Y Rattus norvegicus Norway rat  Rnor\Hdac2 Y Rattus norvegicus Norway rat  Rnor\Hdac1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000025467 Y Homo sapiens Human  Hsap\HDAC3 Y Homo sapiens Human  Hsap\HDAC1 Y Homo sapiens Human  Hsap\ENSG00000196591 Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\HDAC3     Hsap\HDAC1     Hsap\ENSG00000196591
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19615 Drosophila sechellia Dsec\GM10631 Drosophila erecta Dere\GG10995 Drosophila yakuba Dyak\GE25277 Drosophila ananassae Dana\GF17707 Drosophila pseudoobscura pseudoobscura Dpse\GA27397 Drosophila persimilis Dper\GL22163 Drosophila willistoni Dwil\GK11850 Drosophila virilis Dvir\GJ24563 Drosophila mojavensis Dmoj\GI24497 Drosophila grimshawi Dgri\GH18996
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	31633 y1 v1; P{TRiP.JF01420}attP2 34778 y1 sc* v1; P{TRiP.HMS00087}attP2 32248 w*; P{UAS-Hdac3.3xFLAG}attP24; MKRS/TM6B, Tb1 32247 y1 w*; P{UAS-Hdac3.V5}attP24/CyO, y+; MKRS/TM6B, Tb1 34494 w*; P{FRT(whs)}2A P{neoFRT}82B Snr16C Hdac36C/TM6B, Tb1 32246 w*; wgSp-1/CyO; P{FRT(whs)}2A P{neoFRT}82B Hdac3N/TM6B, Tb1
VDRC	v107073 P{KK102732}VIE-260B v20814 w1118; P{GD9732}v20814 v50213 w1118; P{GD16563}v50213/CyO
Genomic Clones ( 2 )
	BACR24O24 BACR34M23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 24 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23745
Other clones	DPiM_LD23745
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17702 GH26548 LD01072 LD35677 LD37067 LD42026 LD46644 LD46675 LP05939 LP23465 RE20551 RE30060 SD26767 SD27965
Other clones	17829 65738 214307.51 CK00519 EK130060 EK193138 EP07534 UT01516
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025825 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44446
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: HDAC3 CG2128 (Bayraktaroglu, 2000.4.17)
Additional comments
Other Comments
	S2 cells which have been treated with dsRNA made from templates generated with primers directed against Hdac3 show inhibition of cell growth. (Foglietti et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143721 RefSeq (Proteins) • NP_651978 DDBJ / EMBL / GenBank • AA820237 AAC83649 AAF52023 AAL28869 AF071559 AI455365 AY061321 Entrez Gene - A searchable database of RefSeq genes. • 44446 UniProtKB/TrEMBL • Q7KTS4 Q9VNC2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Histone deacetylase superfamily (IPR000286) Histone deacetylase (IPR003084) Histone deacetylase domain (IPR023801) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD23745
Linkouts
	BioGRID - A database of protein and genetic interactions • 69064 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025825 DroID - A comprehensive database of gene and protein interactions. • FBgn0025825 DRSC - Results from RNAi screens. • FBgn0025825 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025825 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2128-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025825 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44446 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44446 modMine - Data generated by the modENCODE project. • FBgn0025825
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG2128 (Foglietti et al., 2006, Ardehali et al., 2009, Hayden and Bosco, 2008, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2011.7.19) dHDAC3 (Barlow et al., 2001, Bornemann et al., 2001, Johnson, 1998.6.11, Johnson et al., 1998, Taylor-Harding et al., 2004, Thompson and Travers, 2008, Scharf et al., 2009, Kim et al., 2005) DHDAC3 (Foglietti et al., 2006) dmHDA402 (Pandey et al., 2002) DmHDAC3 (Chen and Courey, 2000) Dromel_CG2128_FBtr0078767_hdac3_mORF (Hayden and Bosco, 2008) HDAC (Guenther and Lazar, 2001, Jones and Kadonaga, 2000, Padmanabhan et al., 2006) HDAC3 (Lai, 2002, Cho et al., 2005, Nègre et al., 2011, Ardehali et al., 2009, Todd et al., 2010, Petesch and Lis, 2008, Qi et al., 2008, Pallos et al., 2008, Tea et al., 2010, Tea and Luo, 2011, Fitzsimons and Scott, 2011, Pushpavalli et al., 2012, Jia et al., 2012, Li et al., 2010) Hdac3 (Gan et al., 2010, Hayden and Bosco, 2008, Dworkin et al., 2009, Japanese National Institute of Genetics, 2012.5.21, Li et al., 2010) hdac3 (Zhu et al., 2008) Hdac 3 (Davis et al., 2011)
Name Synonym	Hdac3   Histone deacetylase 3 (Hayden and Bosco, 2008, ) Histone Deacetylase-3 (Zhu et al., 2008) histone deacetylase 3 (Li et al., 2010)
Secondary FlyBase IDs
	FBgn0037331
References ( 60 )
Generate a list of	All references relating to this gene ( 60 )
List References by type	Research paper  ( 34 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Book review  ( 1 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 9 )
	Staller et al., 2013, Genetics 193(1): 51--61 Depleting Gene Activities in Early Drosophila Embryos with the "Maternal-Gal4-shRNA" System. [FBrf0220341] Jia et al., 2012, Neurobiol. Disease 46(2): 351--361 Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease. [FBrf0218305] Petesch and Lis, 2012, Mol. Cell 45(1): 64--74 Activator-Induced Spread of Poly(ADP-Ribose) Polymerase Promotes Nucleosome Loss at Hsp70. [FBrf0217198] Pushpavalli et al., 2012, Bioorg. Med. Chem. Lett. 22(20): 6418--6424 Imidazo-benzothiazoles a potent microRNA modulator involved in cell proliferation. [FBrf0219513] Davis et al., 2011, BMC Dev. Biol. 11: 66 Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines. [FBrf0216830] Fitzsimons and Scott, 2011, PLoS ONE 6(12): e29171 Genetic modulation of rpd3 expression impairs long-term courtship memory in Drosophila. [FBrf0217042] Kirilly et al., 2011, Neuron 72(1): 86--100 Intrinsic epigenetic factors cooperate with the steroid hormone ecdysone to govern dendrite pruning in Drosophila. [FBrf0216319] Nègre et al., 2011, Nature 471(7339): 527--531 A cis-regulatory map of the Drosophila genome. [FBrf0213303] Tea and Luo, 2011, Neural Dev. 6: 5 The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting. [FBrf0213006] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...