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Gene Dmel\Cortactin

General Information
Symbol	Dmel\Cortactin	Species	D. melanogaster
Name	Cortactin	Annotation symbol	CG3637
Feature type	protein_coding_gene	FlyBase ID	FBgn0025865
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	93B8-93B9	Sequence location	3R:16,887,402..16,890,193 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cortactin is referred to in FlyBase by the symbol Dmel\Cortactin (CG3637, FBgn0025865). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: proline-rich region binding. There is experimental evidence that it is involved in the biological process: regulation of cell shape; positive regulation of receptor-mediated endocytosis; border follicle cell migration; female germline ring canal formation. 20 alleles are reported. The phenotypes of these alleles are annotated with: nurse follicle cell; nurse cell ring canal; egg; border follicle cell. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Cortactin; Hs1/Cortactin; Neutrophil cytosol factor 2 p67phox; Src homology-3 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval midgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1640871_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cortactin. Gene sequence location is 3R:16887402..16890193.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms ruffle lamellipodium
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 93B8-93B9   Limits computationally determined from genome sequence between P{PZ}Atpα01164 and P{PZ}mod(mdg4)07038&P{lacW}mod(mdg4)L3101
Experimentally Determined Cytological Location
Cytogenetic map Notes References 93B-93B   (determined by in situ hybridisation)   (Katsube et al., 2001) 93B3-93B7     (Katsube, 1999.7.16) 93B3-93B6     (Katsube, 1997.12.26)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cortactin for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cortactin-RA FBtr0084039  NM_079702   2416   559 Cortactin-RB FBtr0306347  NM_001260293   2419   559 Cortactin-RC FBtr0306348  NM_001260294   2391   559 Cortactin-RD FBtr0306349  NM_001260295   2388   559
Additional Transcript Data & Comments
Reported size (kB)	2.7 (northern blot) (Katsube et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cortactin-PA   FBpp0083441   61.1   559   4.82     NP_524426   AAF55840 Cortactin-PB   FBpp0297440   61.1   559   4.82     NP_001247222   AFH06540 Cortactin-PC   FBpp0297441   61.1   559   4.82     NP_001247223   AFH06541 Cortactin-PD   FBpp0297442   61.1   559   4.82     NP_001247224   AFH06542
Additional Polypeptide Data & Comments
Reported size (kDa)	559 (aa); 61 (kD predicted) (Katsube et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Neutrophil cytosol factor 2 p67phox (IPR000108) Src homology-3 domain (IPR001452) Hs1/Cortactin (IPR003134) Cortactin (IPR015503)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA950022   AE014297 AAF55840   AB009998 BAA34397   AB030177 BAB01490   AE014297 AFH06540   AE014297 AFH06541   AE014297 AFH06542   AI511738   AI541980   AW943001   AY051774 AAK93198   BG635630   BI163792   BI165804   BI166016   BI234673   BI237971   BI239167   BI239719   BI243321   BI356864   BI364264   BI365007   BI365848   BI372874   BI373531   BI482104   BI487230   BI579772   BI580506   BI641420   CA806391   CK604587   CK604588   CK658950   CK661427   CL528205   CO155457   CO156530   CO310609   CO321664   CO330587   CO335636   CO340307   CZ470613   CZ470677   CZ470678   EC056768   EC063795   EC064700   EC067497   EC074442   EC088592   EC221186   EC262160   EC263877   EC264105   GH750171   GH754545   GH755393   GH770817   GH770879   GH771569   GH775301   GH775966   GH778361   GH779982   GH784920   GH787239   GH787469   GH788401   GH791093   GH793115   GH794360   GH794828   GH795880   GH797318   GH798652   GH802133   GH802959   GH804134   GH810282   GH810645   GH811608   GH814235   GH814866   GH820839   GH822927   GH823476   GH823716   GH828384   GH830873   GH833133   GH835578   GH841445   GH842469   GH842552   GH847615   GH852848   GH853023   GH853455   GH853651   GH855172   GH856252   GH856708   GH857157   GH858037   GH858285   GH861067   GH866652   GH869067   GH870680   GH870906   GH872116   GH872738   GH878684   GH878819   GH879083   GH879161   GH880767   GH883383   GH885581   GH885650   GH886628   GH887855   GH891522   GH893551   GH895595   GH896843   GH899280   GH899360   GH902596   GH904681   GH906850   GH909944   GH910870   GH913674   GH913809   GH914754   GH915922   GH916930   GH916963   GH922173   GH923163   GH926158   GH926602   GH928847   GH930183   GH930222   GH931272   GH933148   GH935348
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VDF4 O96046
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) Comment:reported as ventral nerve cord anlage embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) Malpighian tubule primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) plasmatocyte primordium   (Fisher et al., 2012) Comment:reported as plasmatocytes anlage posterior midgut primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic dorsal epidermis   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) plasmatocyte   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Katsube et al., 1998)
Additional Descriptive Data
	An anti-Cortactin protein antibody recognizes proteins of 105 and 110 kD in all developmental stages, with high levels in embryos, larvae, and pupae, and low levels in adults. The size observed on SDS-PAGE (105 and 110 kD) is much larger than the predicted size (61 kD); a similar disparity has been observed for vertebrate Cortactin, and may be due to the proline-rich domains. (Katsube et al., 1998)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
protein complex inferred from physical interaction with mim (Quinones et al., 2010) sperm individualization complex inferred from direct assay (Rogat and Miller, 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval midgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    301.125 Larval Midgut    928.2 Larval Hindgut    431.8 Larval Malpighian Tubules    314 Larval Fat Body    242.4 Larval Salivary Gland    126.6 Larval Trachea    261.275 Larval Carcass    272.475 Adult Head    110.3 Adult Eye    81.525 Adult Brain    175.5 Adult Thoracic-Abdominal Ganglion    159.5 Adult Crop    139.3 Adult Midgut    367.6 Adult Hindgut    125.4 Adult Malpighian Tubules    221.2 Adult Fat Body    73.7 Adult Salivary Gland    62.8 Adult Heart    96.2 Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    69.4 Adult Ovary    250.3 Adult Testis    146.2 Adult Male Accessory Gland    52.5 Adult Carcass    68.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    301.125 Larval Midgut  (928.2) Larval Hindgut    431.8 Larval Malpighian Tubules    314 Larval Fat Body    242.4 Larval Salivary Gland    126.6 Larval Trachea    261.275 Larval Carcass    272.475 Adult Head    110.3 Adult Eye    81.525 Adult Brain    175.5 Adult Thoracic-Abdominal Ganglion    159.5 Adult Crop    139.3 Adult Midgut    367.6 Adult Hindgut    125.4 Adult Malpighian Tubules    221.2 Adult Fat Body    73.7 Adult Salivary Gland    62.8 Adult Heart    96.2 Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    69.4 Adult Ovary    250.3 Adult Testis    146.2 Adult Male Accessory Gland    52.5 Adult Carcass    68.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    301.125 Larval Midgut    928.2 Larval Hindgut    431.8 Larval Malpighian Tubules    314 Larval Fat Body    242.4 Larval Salivary Gland    126.6 Larval Trachea    261.275 Larval Carcass    272.475 Adult Head    110.3 Adult Eye    81.525 Adult Brain    175.5 Adult Thoracic-Abdominal Ganglion    159.5 Adult Crop    139.3 Adult Midgut    367.6 Adult Hindgut    125.4 Adult Malpighian Tubules    221.2 Adult Fat Body    73.7 Adult Salivary Gland    62.8 Adult Heart    96.2 Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    69.4 Adult Ovary    250.3 Adult Testis    146.2 Adult Male Accessory Gland    52.5 Adult Carcass    68.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    301.125 Larval Midgut    928.2 Larval Hindgut    431.8 Larval Malpighian Tubules    314 Larval Fat Body    242.4 Larval Salivary Gland    126.6 Larval Trachea    261.275 Larval Carcass    272.475 Adult Head    110.3 Adult Eye    81.525 Adult Brain    175.5 Adult Thoracic-Abdominal Ganglion    159.5 Adult Crop    139.3 Adult Midgut    367.6 Adult Hindgut    125.4 Adult Malpighian Tubules    221.2 Adult Fat Body    73.7 Adult Salivary Gland    62.8 Adult Heart    96.2 Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    69.4 Adult Ovary    250.3 Adult Testis    146.2 Adult Male Accessory Gland    52.5 Adult Carcass    68.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    301.125 Larval Midgut    928.2 Larval Hindgut    431.8 Larval Malpighian Tubules    314 Larval Fat Body    242.4 Larval Salivary Gland    126.6 Larval Trachea    261.275 Larval Carcass    272.475 Adult Head    110.3 Adult Eye    81.525 Adult Brain    175.5 Adult Thoracic-Abdominal Ganglion    159.5 Adult Crop    139.3 Adult Midgut    367.6 Adult Hindgut    125.4 Adult Malpighian Tubules    221.2 Adult Fat Body    73.7 Adult Salivary Gland    62.8 Adult Heart    96.2 Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    69.4 Adult Ovary    250.3 Adult Testis    146.2 Adult Male Accessory Gland    52.5 Adult Carcass    68.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    301.125 Larval Midgut  (928.2) Larval Hindgut    431.8 Larval Malpighian Tubules    314 Larval Fat Body    242.4 Larval Salivary Gland    126.6 Larval Trachea    261.275 Larval Carcass    272.475 Adult Head    110.3 Adult Eye    81.525 Adult Brain    175.5 Adult Thoracic-Abdominal Ganglion    159.5 Adult Crop    139.3 Adult Midgut    367.6 Adult Hindgut    125.4 Adult Malpighian Tubules    221.2 Adult Fat Body    73.7 Adult Salivary Gland    62.8 Adult Heart    96.2 Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    69.4 Adult Ovary    250.3 Adult Testis    146.2 Adult Male Accessory Gland    52.5 Adult Carcass    68.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    301.125 Larval Midgut    928.2 Larval Hindgut    431.8 Larval Malpighian Tubules    314 Larval Fat Body    242.4 Larval Salivary Gland    126.6 Larval Trachea    261.275 Larval Carcass    272.475 Adult Head    110.3 Adult Eye    81.525 Adult Brain    175.5 Adult Thoracic-Abdominal Ganglion    159.5 Adult Crop    139.3 Adult Midgut    367.6 Adult Hindgut    125.4 Adult Malpighian Tubules    221.2 Adult Fat Body    73.7 Adult Salivary Gland    62.8 Adult Heart    96.2 Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    69.4 Adult Ovary    250.3 Adult Testis    146.2 Adult Male Accessory Gland    52.5 Adult Carcass    68.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    301.125 Larval Midgut    928.2 Larval Hindgut    431.8 Larval Malpighian Tubules    314 Larval Fat Body    242.4 Larval Salivary Gland    126.6 Larval Trachea    261.275 Larval Carcass    272.475 Adult Head    110.3 Adult Eye    81.525 Adult Brain    175.5 Adult Thoracic-Abdominal Ganglion    159.5 Adult Crop    139.3 Adult Midgut    367.6 Adult Hindgut    125.4 Adult Malpighian Tubules    221.2 Adult Fat Body    73.7 Adult Salivary Gland    62.8 Adult Heart    96.2 Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    69.4 Adult Ovary    250.3 Adult Testis    146.2 Adult Male Accessory Gland    52.5 Adult Carcass    68.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    110.3   NA  Eye    81.525   NA  Brain    175.5   301.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    159.5   NA  Crop    139.3   928.2  Midgut    367.6   431.8  Hindgut    125.4   314  Malpighian Tubules    221.2   242.4  Fat Body    73.7   126.6  Salivary Gland    62.8   NA  Heart    96.2   261.275  Trachea    NA   NA  VirginFemale Spermatheca    55   NA  InseminatedFemale Spermatheca    69.4   NA  Ovary    250.3   NA  Testis    146.2   NA  Male Accessory Gland    52.5   272.475  Carcass    68.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    74 central nervous system, larvae L3    71 central nervous system, pupae P8    64 head, virgin 1-day female    16 head, virgin 4-day female    15 head, virgin 20-day female    16 head, mated 1-day female    13 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    18 head, mated 4-day male    24 head, mated 20-day male    26 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    55 digestive system, larvae L3 wandering    111 digestive system, 1-day adult    48 digestive system, 4-day adult    51 digestive system, 20-day adult    58 fat body, larvae L3 wandering    20 fat body, white prepupae    62 fat body, pupae P8    45 carcass, larvae L3 wandering    77 carcass, 1-day adult    14 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    50 ovary, mated 4-day female    50 testis, mated 4-day male    38 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (74) central nervous system, larvae L3  (71) central nervous system, pupae P8  (64) head, virgin 1-day female    16 head, virgin 4-day female    15 head, virgin 20-day female    16 head, mated 1-day female    13 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    18 head, mated 4-day male    24 head, mated 20-day male  26 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae  (55) digestive system, larvae L3 wandering  (111) digestive system, 1-day adult  (48) digestive system, 4-day adult  (51) digestive system, 20-day adult  (58) fat body, larvae L3 wandering    20 fat body, white prepupae  (62) fat body, pupae P8  (45) carcass, larvae L3 wandering  (77) carcass, 1-day adult    14 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female  (50) ovary, mated 4-day female  (50) testis, mated 4-day male  (38) accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    74 central nervous system, larvae L3    71 central nervous system, pupae P8    64 head, virgin 1-day female    16 head, virgin 4-day female    15 head, virgin 20-day female    16 head, mated 1-day female    13 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    18 head, mated 4-day male    24 head, mated 20-day male    26 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    55 digestive system, larvae L3 wandering  (111) digestive system, 1-day adult    48 digestive system, 4-day adult    51 digestive system, 20-day adult    58 fat body, larvae L3 wandering    20 fat body, white prepupae    62 fat body, pupae P8    45 carcass, larvae L3 wandering    77 carcass, 1-day adult    14 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    50 ovary, mated 4-day female    50 testis, mated 4-day male    38 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    74 central nervous system, larvae L3    71 central nervous system, pupae P8    64 head, virgin 1-day female    16 head, virgin 4-day female    15 head, virgin 20-day female    16 head, mated 1-day female    13 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    18 head, mated 4-day male    24 head, mated 20-day male    26 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    55 digestive system, larvae L3 wandering    111 digestive system, 1-day adult    48 digestive system, 4-day adult    51 digestive system, 20-day adult    58 fat body, larvae L3 wandering    20 fat body, white prepupae    62 fat body, pupae P8    45 carcass, larvae L3 wandering    77 carcass, 1-day adult    14 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    50 ovary, mated 4-day female    50 testis, mated 4-day male    38 accessory gland, mated 4-day male    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    74 central nervous system, larvae L3    71 central nervous system, pupae P8    64 head, virgin 1-day female    16 head, virgin 4-day female    15 head, virgin 20-day female    16 head, mated 1-day female    13 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    18 head, mated 4-day male    24 head, mated 20-day male    26 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    55 digestive system, larvae L3 wandering    111 digestive system, 1-day adult    48 digestive system, 4-day adult    51 digestive system, 20-day adult    58 fat body, larvae L3 wandering    20 fat body, white prepupae    62 fat body, pupae P8    45 carcass, larvae L3 wandering    77 carcass, 1-day adult    14 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    50 ovary, mated 4-day female    50 testis, mated 4-day male    38 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (74) central nervous system, larvae L3  (71) central nervous system, pupae P8  (64) head, virgin 1-day female    16 head, virgin 4-day female    15 head, virgin 20-day female    16 head, mated 1-day female    13 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    18 head, mated 4-day male    24 head, mated 20-day male  26 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae  (55) digestive system, larvae L3 wandering  (111) digestive system, 1-day adult  (48) digestive system, 4-day adult  (51) digestive system, 20-day adult  (58) fat body, larvae L3 wandering    20 fat body, white prepupae  (62) fat body, pupae P8  (45) carcass, larvae L3 wandering  (77) carcass, 1-day adult    14 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female  (50) ovary, mated 4-day female  (50) testis, mated 4-day male  (38) accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    74 central nervous system, larvae L3    71 central nervous system, pupae P8    64 head, virgin 1-day female    16 head, virgin 4-day female    15 head, virgin 20-day female    16 head, mated 1-day female    13 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    18 head, mated 4-day male    24 head, mated 20-day male    26 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    55 digestive system, larvae L3 wandering  111 digestive system, 1-day adult    48 digestive system, 4-day adult    51 digestive system, 20-day adult    58 fat body, larvae L3 wandering    20 fat body, white prepupae    62 fat body, pupae P8    45 carcass, larvae L3 wandering    77 carcass, 1-day adult    14 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    50 ovary, mated 4-day female    50 testis, mated 4-day male    38 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    74 central nervous system, larvae L3    71 central nervous system, pupae P8    64 head, virgin 1-day female    16 head, virgin 4-day female    15 head, virgin 20-day female    16 head, mated 1-day female    13 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    18 head, mated 4-day male    24 head, mated 20-day male    26 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    55 digestive system, larvae L3 wandering    111 digestive system, 1-day adult    48 digestive system, 4-day adult    51 digestive system, 20-day adult    58 fat body, larvae L3 wandering    20 fat body, white prepupae    62 fat body, pupae P8    45 carcass, larvae L3 wandering    77 carcass, 1-day adult    14 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    50 ovary, mated 4-day female    50 testis, mated 4-day male    38 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    57 embryo 04-06hr    71 embryo 06-08hr    72 embryo 08-10hr    67 embryo 10-12hr    55 embryo 12-14hr    49 embryo 14-16hr    41 embryo 16-18hr    30 embryo 18-20hr    20 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    16 larva L2    25 larva L3 12hr old    17 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    62 white prepupae new    88 white prepupae 12hr    73 white prepupae 24hr    65 pupae 2d postWPP    47 pupae 3d postWPP    21 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    17 adult female 01day    24 adult female 05day    35 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (46) embryo 02-04hr  (57) embryo 04-06hr  (71) embryo 06-08hr  (72) embryo 08-10hr  (67) embryo 10-12hr  (55) embryo 12-14hr  (49) embryo 14-16hr  (41) embryo 16-18hr  (30) embryo 18-20hr    20 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    16 larva L2    25 larva L3 12hr old    17 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6  (40) larva L3 puffstage 7-9  (62) white prepupae new  (88) white prepupae 12hr  (73) white prepupae 24hr  (65) pupae 2d postWPP  (47) pupae 3d postWPP    21 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    17 adult female 01day    24 adult female 05day  (35) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    57 embryo 04-06hr    71 embryo 06-08hr    72 embryo 08-10hr    67 embryo 10-12hr    55 embryo 12-14hr    49 embryo 14-16hr    41 embryo 16-18hr    30 embryo 18-20hr    20 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    16 larva L2    25 larva L3 12hr old    17 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    62 white prepupae new    88 white prepupae 12hr    73 white prepupae 24hr    65 pupae 2d postWPP    47 pupae 3d postWPP    21 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    17 adult female 01day    24 adult female 05day    35 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    57 embryo 04-06hr    71 embryo 06-08hr    72 embryo 08-10hr    67 embryo 10-12hr    55 embryo 12-14hr    49 embryo 14-16hr    41 embryo 16-18hr    30 embryo 18-20hr    20 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    16 larva L2    25 larva L3 12hr old    17 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    62 white prepupae new    88 white prepupae 12hr    73 white prepupae 24hr    65 pupae 2d postWPP    47 pupae 3d postWPP    21 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    17 adult female 01day    24 adult female 05day    35 adult female 30day    34 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    57 embryo 04-06hr    71 embryo 06-08hr    72 embryo 08-10hr    67 embryo 10-12hr    55 embryo 12-14hr    49 embryo 14-16hr    41 embryo 16-18hr    30 embryo 18-20hr    20 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    16 larva L2    25 larva L3 12hr old    17 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    62 white prepupae new    88 white prepupae 12hr    73 white prepupae 24hr    65 pupae 2d postWPP    47 pupae 3d postWPP    21 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    17 adult female 01day    24 adult female 05day    35 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (46) embryo 02-04hr  (57) embryo 04-06hr  (71) embryo 06-08hr  (72) embryo 08-10hr  (67) embryo 10-12hr  (55) embryo 12-14hr  (49) embryo 14-16hr  (41) embryo 16-18hr  30 embryo 18-20hr    20 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    16 larva L2    25 larva L3 12hr old    17 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6  (40) larva L3 puffstage 7-9  (62) white prepupae new  (88) white prepupae 12hr  (73) white prepupae 24hr  (65) pupae 2d postWPP  (47) pupae 3d postWPP    21 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    17 adult female 01day    24 adult female 05day  (35) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    57 embryo 04-06hr    71 embryo 06-08hr    72 embryo 08-10hr    67 embryo 10-12hr    55 embryo 12-14hr    49 embryo 14-16hr    41 embryo 16-18hr    30 embryo 18-20hr    20 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    16 larva L2    25 larva L3 12hr old    17 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    62 white prepupae new    88 white prepupae 12hr    73 white prepupae 24hr    65 pupae 2d postWPP    47 pupae 3d postWPP    21 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    17 adult female 01day    24 adult female 05day    35 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    57 embryo 04-06hr    71 embryo 06-08hr    72 embryo 08-10hr    67 embryo 10-12hr    55 embryo 12-14hr    49 embryo 14-16hr    41 embryo 16-18hr    30 embryo 18-20hr    20 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    16 larva L2    25 larva L3 12hr old    17 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    62 white prepupae new    88 white prepupae 12hr    73 white prepupae 24hr    65 pupae 2d postWPP    47 pupae 3d postWPP    21 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    18 adult male 30day    17 adult female 01day    24 adult female 05day    35 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    243 Schneider line 2 Sg4    131 embryonic 1182-4H    225 embryonic GM2    246 embryonic Kc167    138 embryonic S1    179 embryonic S3    77 leg disc CME L1    197 wing disc CME-W2    122 wing disc ML-DmD8    149 wing disc ML-DmD9    159 wing disc ML-DmD16-c3    122 wing disc ML-DmD21    117 wing disc ML-DmD32    156 haltere disc ML-DmD17-c3    116 eye-antennal disc ML-DmD11    116 antennal disc ML-DmD20-c5    132 mixed discs ML-DmD4-c1    196 CNS ML-DmBG1-c1    166 CNS ML-DmBG2-c2    61 tumorous blood cells mbn2    238 ovary fGS/OSS    109 ovary OSC    60 ovary OSS    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (243) Schneider line 2 Sg4  (131) embryonic 1182-4H  (225) embryonic GM2  (246) embryonic Kc167  (138) embryonic S1  (179) embryonic S3  (77) leg disc CME L1  (197) wing disc CME-W2  (122) wing disc ML-DmD8  (149) wing disc ML-DmD9  (159) wing disc ML-DmD16-c3  (122) wing disc ML-DmD21  (117) wing disc ML-DmD32  (156) haltere disc ML-DmD17-c3  (116) eye-antennal disc ML-DmD11  (116) antennal disc ML-DmD20-c5  (132) mixed discs ML-DmD4-c1  (196) CNS ML-DmBG1-c1  (166) CNS ML-DmBG2-c2  (61) tumorous blood cells mbn2  (238) ovary fGS/OSS  (109) ovary OSC  (60) ovary OSS  (85) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (243) Schneider line 2 Sg4  (131) embryonic 1182-4H  (225) embryonic GM2  (246) embryonic Kc167  (138) embryonic S1  (179) embryonic S3    77 leg disc CME L1  (197) wing disc CME-W2  (122) wing disc ML-DmD8  (149) wing disc ML-DmD9  (159) wing disc ML-DmD16-c3  (122) wing disc ML-DmD21  (117) wing disc ML-DmD32  (156) haltere disc ML-DmD17-c3  (116) eye-antennal disc ML-DmD11  (116) antennal disc ML-DmD20-c5  (132) mixed discs ML-DmD4-c1  (196) CNS ML-DmBG1-c1  (166) CNS ML-DmBG2-c2    61 tumorous blood cells mbn2  (238) ovary fGS/OSS  (109) ovary OSC    60 ovary OSS    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    243 Schneider line 2 Sg4    131 embryonic 1182-4H    225 embryonic GM2    246 embryonic Kc167    138 embryonic S1    179 embryonic S3    77 leg disc CME L1    197 wing disc CME-W2    122 wing disc ML-DmD8    149 wing disc ML-DmD9    159 wing disc ML-DmD16-c3    122 wing disc ML-DmD21    117 wing disc ML-DmD32    156 haltere disc ML-DmD17-c3    116 eye-antennal disc ML-DmD11    116 antennal disc ML-DmD20-c5    132 mixed discs ML-DmD4-c1    196 CNS ML-DmBG1-c1    166 CNS ML-DmBG2-c2    61 tumorous blood cells mbn2    238 ovary fGS/OSS    109 ovary OSC    60 ovary OSS    85 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    243 Schneider line 2 Sg4    131 embryonic 1182-4H    225 embryonic GM2    246 embryonic Kc167    138 embryonic S1    179 embryonic S3    77 leg disc CME L1    197 wing disc CME-W2    122 wing disc ML-DmD8    149 wing disc ML-DmD9    159 wing disc ML-DmD16-c3    122 wing disc ML-DmD21    117 wing disc ML-DmD32    156 haltere disc ML-DmD17-c3    116 eye-antennal disc ML-DmD11    116 antennal disc ML-DmD20-c5    132 mixed discs ML-DmD4-c1    196 CNS ML-DmBG1-c1    166 CNS ML-DmBG2-c2    61 tumorous blood cells mbn2    238 ovary fGS/OSS    109 ovary OSC    60 ovary OSS    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (243) Schneider line 2 Sg4  (131) embryonic 1182-4H  (225) embryonic GM2  (246) embryonic Kc167  (138) embryonic S1  (179) embryonic S3  (77) leg disc CME L1  (197) wing disc CME-W2  (122) wing disc ML-DmD8  (149) wing disc ML-DmD9  (159) wing disc ML-DmD16-c3  (122) wing disc ML-DmD21  (117) wing disc ML-DmD32  (156) haltere disc ML-DmD17-c3  (116) eye-antennal disc ML-DmD11  (116) antennal disc ML-DmD20-c5  (132) mixed discs ML-DmD4-c1  (196) CNS ML-DmBG1-c1  (166) CNS ML-DmBG2-c2  (61) tumorous blood cells mbn2  (238) ovary fGS/OSS  (109) ovary OSC  (60) ovary OSS  (85) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (243) Schneider line 2 Sg4  131 embryonic 1182-4H  (225) embryonic GM2  (246) embryonic Kc167  138 embryonic S1  (179) embryonic S3    77 leg disc CME L1  (197) wing disc CME-W2  122 wing disc ML-DmD8  (149) wing disc ML-DmD9  (159) wing disc ML-DmD16-c3  122 wing disc ML-DmD21  117 wing disc ML-DmD32  (156) haltere disc ML-DmD17-c3  116 eye-antennal disc ML-DmD11  116 antennal disc ML-DmD20-c5  132 mixed discs ML-DmD4-c1  (196) CNS ML-DmBG1-c1  (166) CNS ML-DmBG2-c2    61 tumorous blood cells mbn2  (238) ovary fGS/OSS  109 ovary OSC    60 ovary OSS    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    243 Schneider line 2 Sg4    131 embryonic 1182-4H    225 embryonic GM2    246 embryonic Kc167    138 embryonic S1    179 embryonic S3    77 leg disc CME L1    197 wing disc CME-W2    122 wing disc ML-DmD8    149 wing disc ML-DmD9    159 wing disc ML-DmD16-c3    122 wing disc ML-DmD21    117 wing disc ML-DmD32    156 haltere disc ML-DmD17-c3    116 eye-antennal disc ML-DmD11    116 antennal disc ML-DmD20-c5    132 mixed discs ML-DmD4-c1    196 CNS ML-DmBG1-c1    166 CNS ML-DmBG2-c2    61 tumorous blood cells mbn2    238 ovary fGS/OSS    109 ovary OSC    60 ovary OSS    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    49 cold shock, 4-day adult    35 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    41 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    30 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (49) cold shock, 4-day adult  (35) heat shock, 4-day adult  (33) Cadmium 50 mM 6 hrs, larvae L3  (29) Cadmium 50 mM 12 hrs, larvae L3  (31) Cadmium 50 mM 48 hrs, 4-day adult  (39) Cadmium 100 mM 48 hrs, 4-day adult  (50) Copper 0.5 mM 12 hrs, larvae L3  (41) Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3  (36) Zinc 4.5 mM 48 hrs, 4-day adult  (34) Ethanol 2.5% 3 hrs, larvae L3  (45) Ethanol 5% 3 hrs, larvae L3  (33) Ethanol 10% 3 hrs, larvae L3  (28) Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (41) Caffeine 25 mg/ml 48 hrs, 4-day adult  (36) Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult  (42) Rotenone 2 μg 12 hrs, larvae L3  (30) Rotenone 8 μg 12 hrs, larvae L3  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    49 cold shock, 4-day adult    35 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    41 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    30 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    49 cold shock, 4-day adult    35 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    41 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    30 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    49 cold shock, 4-day adult    35 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    41 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    30 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (49) cold shock, 4-day adult  (35) heat shock, 4-day adult  (33) Cadmium 50 mM 6 hrs, larvae L3  29 Cadmium 50 mM 12 hrs, larvae L3  31 Cadmium 50 mM 48 hrs, 4-day adult  (39) Cadmium 100 mM 48 hrs, 4-day adult  (50) Copper 0.5 mM 12 hrs, larvae L3  (41) Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3  (36) Zinc 4.5 mM 48 hrs, 4-day adult  (34) Ethanol 2.5% 3 hrs, larvae L3  (45) Ethanol 5% 3 hrs, larvae L3  (33) Ethanol 10% 3 hrs, larvae L3  28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (41) Caffeine 25 mg/ml 48 hrs, 4-day adult  (36) Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult  (42) Rotenone 2 μg 12 hrs, larvae L3  30 Rotenone 8 μg 12 hrs, larvae L3  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    49 cold shock, 4-day adult    35 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    41 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    30 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    49 cold shock, 4-day adult    35 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    41 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    33 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    42 Rotenone 2 μg 12 hrs, larvae L3    30 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD29964 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025865 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3637-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Cortactin Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Cortactin6A2 CortactinA4 CortactinD4 CortactinEY10111 CortactinK8 CortactinM7 Sterility Allele female fertile | reduced CortactinA4 CortactinD4 CortactinK8 CortactinM7 fertile CortactinEY10111 Phenotype manifest in Allele actin filament | ectopic, with Scer\GAL4Act5C.PP CortactinScer\UAS.cSa border follicle cell CortactinM7 border follicle cell | cell autonomous | somatic clone CortactinM7 egg CortactinD4 CortactinM7 nurse cell ring canal CortactinD4 CortactinM7 nurse follicle cell CortactinD4 CortactinM7
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of Cortactin Class Mutagen Stocks Known lesion Cortactin6A2 P-element activity 1 Yes Cortactinc05667 1 -- CortactinEY10111 P-element activity 1 -- CortactinEY20304 P-element activity 1 -- CortactinA4 Delta2-3 0 Yes Cortactinc06340 piggyBac transposase 0 -- Cortactinc06419 piggyBac transposase 0 -- CortactinD4 Delta2-3 0 Yes CortactinEPg35301 0 Yes CortactinK8 Delta2-3 0 Yes CortactinM7 Delta2-3 0 Yes Cortactinneo54 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cortactin Class Mutagen Stocks Known lesion CortactinHMS00658 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CortactinKK108594 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CortactinScer\UAS.T:Ivir\HA1 1 Yes CortactinGD11035 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CortactinNIG.3637R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CortactinScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes Cortactinunspecified in vitro construct - regulatory fusion 0 -- CortactinαTub.PS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6272 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11035} NA P{KK108594} NA P{NIG.3637R} NA P{TRiP.HMS00658} NA P{UAS-Cortactin.HA3} NA characterization construct P{tub-cortactin.S} NA P{UAS-Cortactin.S} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPg}CortactinEPg35301 NA P{EPgy2}CortactinEY10111 NA P{EPgy2}CortactinEY20304 NA miscellaneous insertions P{hsneo}Cortactinneo54 NA PBac{PB}Cortactinc05667 NA PBac{PB}Cortactinc06340 NA PBac{PB}Cortactinc06419 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
proline-rich region binding inferred from genetic interaction with mim (Quinones et al., 2010)
Biological Process
CV term Evidence References
border follicle cell migration inferred from mutant phenotype (Somogyi and Rorth, 2004, Quinones et al., 2010) female germline ring canal formation inferred from mutant phenotype (Somogyi and Rorth, 2004) positive regulation of receptor-mediated endocytosis inferred from genetic interaction with mim (Quinones et al., 2010) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003)
Cellular Component
CV term Evidence References
protein complex inferred from physical interaction with mim (Quinones et al., 2010) sperm individualization complex inferred from direct assay (Rogat and Miller, 2002)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytoskeleton organization inferred from sequence or structural similarity with UniProtKB:Q60598 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytoskeleton inferred from sequence or structural similarity with UniProtKB:Q60598 (FlyBase, 1992-) lamellipodium inferred from electronic annotation with InterPro:IPR015503 (FlyBase Curators et al., 2004-) ruffle inferred from electronic annotation with InterPro:IPR015503 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Cortactin - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - Arpc3A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - Arpc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - CG10641 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - CG13321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - CG7091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - Cht2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - FK506-bp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - Myo61F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - Pgam5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - cpb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cortactin - mim anti bait coimmunoprecipitation, anti tag western blot, pull down (Quinones et al., 2010) Cortactin - tmod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cortactin allele Gene References unspecified Pvr (Somogyi and Rorth, 2004) Src42A (Somogyi and Rorth, 2004)
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025865 DroID - A comprehensive database of gene and protein interactions. • FBgn0025865 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42491 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O96046
Orthologs
OrthoDB Orthologs (34) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XD49T Dipteran inclusive ortholog search EOG6M65S0 Insect inclusive ortholog search EOG6MSBV0 Arthropod inclusive ortholog search EOG6V15GM Metazoa inclusive ortholog search EOG6W196N
Orthologs in Drosophila Species (EOG6XD49T)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Cortactin     Drosophila simulans   Dsim\GD20012 Y   Drosophila sechellia   Dsec\GM15108 Y   Drosophila erecta   Dere\GG14937 Y   Drosophila ananassae   Dana\GF18522 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17577 Y   Drosophila persimilis   Dper\GL12684 Y   Drosophila willistoni   Dwil\GK13516 Y   Drosophila virilis   Dvir\GJ10159 Y   Drosophila mojavensis   Dmoj\GI10305 Y   Drosophila grimshawi   Dgri\GH23174 Y
Orthologs in non-Drosophila Dipterans (EOG6M65S0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011982   Anopheles gambiae Malaria mosquito  Agam\AGAP004625   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006351
Orthologs in non-Dipteran Insects (EOG6MSBV0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Acyrthosiphon pisum Pea aphid  Apim\ACYPI009473   Bombyx mori Silkmoth  Bmor\BGIBMGA010072   Pediculus humanus Human body louse  Phum\PHUM488860   Tribolium castaneum Red flour beetle  Tcas\TC005204
Orthologs in non-Insect Arthropods (EOG6V15GM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_305633   Ixodes scapularis Deer tick  Isca\ISCW000141
Orthologs in non-Arthropod Metazoa (EOG6W196N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007339gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024620gn   Danio rerio Zebrafish  Drer\si:dkey-9a20.6   Danio rerio Zebrafish  Drer\cttn   Xenopus tropicalis Western clawed frog  Xtro\hcls1   Xenopus tropicalis Western clawed frog  Xtro\cttn   Gallus gallus Domestic chicken  Ggal\HCLS1   Gallus gallus Domestic chicken  Ggal\CTTN   Mus musculus House mouse  Mmus\Cttn   Mus musculus House mouse  Mmus\Hcls1   Rattus norvegicus Norway rat  Rnor\Hcls1   Rattus norvegicus Norway rat  Rnor\Cttn   Homo sapiens Human  Hsap\CTTN   Homo sapiens Human  Hsap\HCLS1
Human Orthologs (2)
Gene OMIM HGNC Hsap\CTTN     Hsap\HCLS1
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20012 Drosophila sechellia Dsec\GM15108 Drosophila erecta Dere\GG14937 Drosophila ananassae Dana\GF18522 Drosophila pseudoobscura pseudoobscura Dpse\GA17577 Drosophila persimilis Dper\GL12684 Drosophila willistoni Dwil\GK13516 Drosophila virilis Dvir\GJ10159 Drosophila mojavensis Dmoj\GI10305 Drosophila grimshawi Dgri\GH23174
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	9367 w*; Cortactin6A2/TM6B, Tb1 32871 y1 sc* v1; P{TRiP.HMS00658}attP2 16968 y1 w67c23; P{EPgy2}CortactinEY10111 9368 y1 w*; P{UAS-Cortactin.HA3}2; MKRS/TM6B, Tb1 22381 y1 w67c23; P{EPgy2}CortactinEY20304/TM3, Sb1 Ser1
Harvard	- PBac{PB}Cortactinc05667
VDRC	v105289 P{KK108594}VIE-260B
Genomic Clones ( 2 )
	BACR05I01 BACR20N14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 140 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD29964
Other clones	DPiM_LD29964
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD43239 LP16293 LP20946 RE03295 RE05763 RE06034 RE30417 RE34318 RE35582 RE36288 RE40921 RE43125 RE49337 RE50225 RE51237 RE60066 RE60846 RE64755 RE70752 RE73852 RE74712 SD07972 SD13090 SD24740
Other clones	28961 61110 74099 99593 121680 192662 524875 528018 542573 CK01.114D.E9 EK186129 EK222119 EK295635 EN06061 EN08239 EN10861 EP10404 ESG013a.E21.1_F07 RP003012102 RP003014942 RP003020378 RP003020768 RP003027894 RP003034360 RP003038669 RP003044819 RP003056038 RP003056471 RP003058000 RP003084318 RP003089238 RP003090341 RP003090433 RP003090973 RP003097168 RP003102292 RP003107592 RP003111863 RP003122749 RP003123543 RP003147852 RP003152490 RP003155946 RP003158671 RP003160751 RP003170627 RP003177428 RP003201361 RP003208028 RP003212157 RP003216122 RP003221711 RP003232452 RP003233213 RP003235652 RP003252943 RP003254058 RP003255231 RP003255247 RP003255413 RP003255713 RP003264848 RP003273647 RP003278649 RP003279886 RP003289178 RP003298518 RP003322708 RP003336742 RP003338143 RP003373685 RP003383419 RP003388127 RP003389615 RP003392293 RP003393685 RP003393906 RP003394399 RP003398647 RP003420295 RP003424258 RP003433299 RP003440439 RP003450855 RP003451082 RP003451849 RP003457642 RP003466954 RP003480594 RP003494089 RP003496802 RP003501727 RP003506817 RP003516816 RP003527468 RP003531419 RP003541407 RP003543720 RP003548977 RP003551940 RP003554694 RP003566173 RP003589145 RP003590188 RP003590205 RP003607720 RP003617618 RP003632978 RP003638675 RP003652333 RP003660259 RP003663123 RP003668259 UT01301
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025865 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42491
Antibody Information
	polyclonal (Katsube et al., 1998)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Cortactin CG3637 (Gong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Cortactin modulates cell migration and ring canal morphogenesis during oogenesis. (Somogyi and Rorth, 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become retracted (unspread but flat). Kc167 cells are unaffected. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079702 NM_001260293 NM_001260294 NM_001260295 RefSeq (Proteins) • NP_524426 NP_001247222 NP_001247223 NP_001247224 DDBJ / EMBL / GenBank • AA950022 AAF55840 AAK93198 AB009998 AB030177 AFH06540 AFH06541 AFH06542 AW943001 AY051774 BAA34397 BAB01490 CL528205 CZ470613 CZ470677 CZ470678 Entrez Gene - A searchable database of RefSeq genes. • 42491 UniProtKB/TrEMBL • O96046 Q9VDF4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Neutrophil cytosol factor 2 p67phox (IPR000108) Src homology-3 domain (IPR001452) Hs1/Cortactin (IPR003134) Cortactin (IPR015503) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD29964
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025865 DroID - A comprehensive database of gene and protein interactions. • FBgn0025865 DRSC - Results from RNAi screens. • FBgn0025865 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025865 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3637-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025865 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42491 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/cortactin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42491 modMine - Data generated by the modENCODE project. • FBgn0025865 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O96046
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG3637 (Rogers et al., 2003, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) Cortactin (Elwell et al., 2008, Japanese National Institute of Genetics, 2012.5.21) cortactin (Mudiganti et al., 2010, Rogat and Miller, 2002) cttn (Quinones et al., 2010)
Name Synonym	cortactin (Ueda et al., 1999, Somogyi and Rorth, 2004, Watson et al., 2001, Quinones et al., 2010, Isaji et al., 2011) Cortactin (Rogers et al., 2003, Elwell et al., 2008, Kim et al., 2005, Regnard et al., 2011) DCortactin (Katsube et al., 1998, Katsube et al., 2001, Katsube, 1997.12.26)
Secondary FlyBase IDs
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 5 ) Review  ( 3 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 )
Recent research papers ( 2 )
	Isaji et al., 2011, PLoS ONE 6(8): e22755 Myosin VI Regulates Actin Structure Specialization through Conserved Cargo-Binding Domain Sites. [FBrf0214724] Regnard et al., 2011, PLoS Genet. 7(3): e1001327 Global Analysis of the Relationship between JIL-1 Kinase and Transcription. [FBrf0213276] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...