FB2020_06, released Dec 22, 2020

Gene: Dmel\wrapper

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General Information
Symbol
Dmel\wrapper
Species
D. melanogaster
Name
wrapper
Annotation Symbol
CG10382
Feature Type
protein_coding_gene
FlyBase ID
FBgn0025878
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
wrapper (wrapper) encodes a protein involved in axon ensheathment and glial apoptosis. [Date last reviewed: 2019-09-19]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
58D4-58D4
Sequence location
2R:22,379,637..22,382,675 [+]
Recombination map

2-99

RefSeq locus
NT_033778 REGION:22379637..22382675
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables axon guidance receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN002895063
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in axon development
inferred from mutant phenotype
(Noordermeer et al., 1998)
involved_in axon ensheathment
inferred from mutant phenotype
(Noordermeer et al., 1998)
involved_in glial cell apoptotic process
inferred from mutant phenotype
(Noordermeer et al., 1998)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in homophilic cell adhesion via plasma membrane adhesion molecules
inferred from biological aspect of ancestor with PANTHER:PTN002895062
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in synapse organization
inferred from biological aspect of ancestor with PANTHER:PTN002895063
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in axon
inferred from biological aspect of ancestor with PANTHER:PTN002895063
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in neuronal cell body
inferred from biological aspect of ancestor with PANTHER:PTN002895063
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002895062
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
KLINGON SUBFAMILY OF WIRINS -
Wirins are members of a widely distributed family of two- and three-Ig domain molecules that mediate axonal guidance, synapse targeting, and other neuronal wiring-related functions. The Klingon subfamily expanded within hexapods, resulting in four paralogs in D. melanogaster. (Adapted from FBrf0245249.)
Summary (Interactive Fly)

Immunoglobulin domain ligand - present in midline glia - required, along with neuronally-expressed Neurexin IV, for ensheathment of commissural axons

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\wrapper for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
wrapper-RA
FBtr0071821
NM_058056
1977
500
Additional Transcript Data and Comments
Reported size (kB)

2.0 (northern blot)

(Noordermeer et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
wrapper-PA
FBpp0071732
55.5
500
5.96
NP_477404
AAF46838
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

500 (aa)

(Noordermeer et al., 1998)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wrapper using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval brain
(Noordermeer et al., 1998)
ventral midline of embryo
(Noordermeer et al., 1998)
PNS glial cell
(Noordermeer et al., 1998)
embryonic stage 17
glial cell of embryonic brain
(Noordermeer et al., 1998)
midline glial cell
(Wheeler et al., 2006)
embryonic stage 12 -- 17
midline glial cell
(Noordermeer et al., 1998)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic/larval lymph gland
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
midline ventral glial cell
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
midline glial cell
(Kearney et al., 2004)
embryonic stage 11
posterior midline glial cell
(Wheeler et al., 2006)
midline glial cell
(Wheeler et al., 2006)
embryonic stage 13
posterior midline glial cell
(Wheeler et al., 2006)
midline glial cell
(Wheeler et al., 2006)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 12
midline glial cell

Comment: high level

(Watson et al., 2011)
posterior midline glial cell

Comment: low level

(Watson et al., 2011)
embryonic stage 16 -- 17
midline glial cell
(Fontana and Crews, 2012)
RNA-seq
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 12
ventral midline of embryo
(Fontana and Crews, 2012)
embryonic stage 16
ventral midline of embryo
(Fontana and Crews, 2012)
Additional Descriptive Data

wrapper is expressed at a high level in anterior midline glia and at a low level in posterior midline glia in stage 12 embryos.

(Watson et al., 2011)

Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.

(Wheeler et al., 2006)

wrapper transcripts are first detected in stage 12 embryos in the midline glia. They are most prominent on two pairs of midline glia, MGA and MGM, but are also observed at a lower level on the third pair, MGP. They persist until the end of embryogenesis. By stage 17, they are also observed at a low level on some lateral glia and on glia throughout the embryonic brain. wrapper transcripts are observed in third instar larvae along the midline and throughout the brain. Weak expression is observed in the glia supporting the chordotonal s nsory organs of the PNS.

(Noordermeer et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 17
glial cell of embryonic brain
(Noordermeer et al., 1998)
third instar larval stage
ventral midline of embryo
(Noordermeer et al., 1998)
embryonic/larval brain
(Noordermeer et al., 1998)
embryonic stage 12 -- 17
midline glial cell
(Noordermeer et al., 1998)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

wrapper protein is first detected in stage 12 embryos in the midline glia. It is most prominent on two pairs of midline glia, MGA and MGM, but is also observed at a lower level on the third pair, MGP. It persists until the end of embryogenesis. By stage 17, it is also observed at a low level on some lateral glia and on glia throughout the embryonic brain. wrapper protein is observed in third instar larvae along the midline and throughout the brain. Weak expression is observed in the glia supporting the chordotonal sensory organs of t e PNS.

(Noordermeer et al., 1998)
Marker for
 
midline glial cell
(Bashaw et al., 2001)
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GMR54H02-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
midline glial cell
(Banerjee et al., 2017)
embryonic/larval neuron | subset
(Banerjee et al., 2017)
third instar larval stage
embryonic/larval CNS subperineurial glial cell
(Coutinho-Budd et al., 2017)
embryonic/larval cell body glial cell
(Coutinho-Budd et al., 2017)
ventral nerve cord | restricted
(Coutinho-Budd et al., 2017)
embryonic/larval Malpighian tubule
(Coutinho-Budd et al., 2017)
optic-lobe-associated cortex glial cell
(Coutinho-Budd et al., 2017)
adult stage
adult brain cell body glial cell
(Hill et al., 2019, Coutinho-Budd et al., 2017, Kremer et al., 2017)
embryonic stage -- larval stage
embryonic/larval cell body glial cell
(Kremer et al., 2017)
Reporter: P{wrapper-GAL4.CH321-61P08}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 12 -- 16
midline glial cell
(Banerjee et al., 2017)
third instar larval stage
midline glial cell
(Banerjee et al., 2017)
Reporter: P{wrapper-GAL4.DBD.932i}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval cell body glial cell

Comment: when combined with P{nrv2-VP16.AD}

(Coutinho-Budd et al., 2017)
embryonic stage 12
embryonic/larval cell body glial cell

Comment: when combined with P{nrv2-VP16.AD}

(Coutinho-Budd et al., 2017)
embryonic stage 15
embryonic/larval cell body glial cell

Comment: when combined with P{nrv2-VP16.AD}

(Coutinho-Budd et al., 2017)
first instar larval stage
embryonic/larval cell body glial cell

Comment: when combined with P{nrv2-VP16.AD}

(Coutinho-Budd et al., 2017)
second instar larval stage
embryonic/larval cell body glial cell

Comment: when combined with P{nrv2-VP16.AD}

(Coutinho-Budd et al., 2017)
adult stage
adult brain cell body glial cell

Comment: when combined with P{nrv2-VP16.AD}

(Coutinho-Budd et al., 2017)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\wrapper in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of wrapper
Transgenic constructs containing regulatory region of wrapper
Deletions and Duplications ( 2 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\IGLON5
2 of 15
Yes
No
Hsap\LSAMP
2 of 15
Yes
No
Hsap\NEGR1
2 of 15
Yes
No
1  
Hsap\NTM
2 of 15
Yes
No
Hsap\OPCML
2 of 15
Yes
No
Hsap\DSCAM
1 of 15
No
No
3  
Hsap\DSCAML1
1 of 15
No
No
2  
Hsap\IGSF9B
1 of 15
No
No
Hsap\IGSF9
1 of 15
No
No
2  
Hsap\KIRREL1
1 of 15
No
No
Hsap\KIRREL2
1 of 15
No
No
Hsap\KIRREL3
1 of 15
No
No
Hsap\LRIT1
1 of 15
No
Yes
Hsap\LRIT3
1 of 15
No
Yes
Hsap\MYOT
1 of 15
No
Yes
Hsap\NCAM1
1 of 15
No
No
4  
Hsap\NCAM2
1 of 15
No
No
Hsap\PAPLN
1 of 15
No
No
Hsap\PTPRQ
1 of 15
No
No
Hsap\SDK1
1 of 15
No
No
Hsap\SDK2
1 of 15
No
No
1  
Hsap\USH2A
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Iglon5
2 of 15
Yes
No
Mmus\Lsamp
2 of 15
Yes
No
Mmus\Negr1
2 of 15
Yes
No
Mmus\Ntm
2 of 15
Yes
No
Mmus\Opcml
2 of 15
Yes
No
Mmus\Dscaml1
1 of 15
No
No
Mmus\Dscam
1 of 15
No
No
1  
Mmus\Fgfrl1
1 of 15
No
No
Mmus\Igsf9b
1 of 15
No
No
Mmus\Igsf9
1 of 15
No
No
Mmus\Kirrel2
1 of 15
No
No
1  
Mmus\Kirrel3
1 of 15
No
No
1  
Mmus\Kirrel
1 of 15
No
No
1  
Mmus\Lrit1
1 of 15
No
Yes
Mmus\Lrit3
1 of 15
No
Yes
Mmus\Ncam1
1 of 15
No
No
Mmus\Ncam2
1 of 15
No
No
Mmus\Palld
1 of 15
No
No
Mmus\Papln
1 of 15
No
No
Mmus\Ptprq
1 of 15
No
No
Mmus\Sdk1
1 of 15
No
No
Mmus\Sdk2
1 of 15
No
No
Rattus norvegicus (Norway rat) (18)
Rnor\Iglon5
2 of 13
Yes
No
Rnor\Lsamp
2 of 13
Yes
No
Rnor\Ntm
2 of 13
Yes
No
Rnor\Opcml
2 of 13
Yes
No
Rnor\Dscaml1
1 of 13
No
No
Rnor\Dscam
1 of 13
No
No
Rnor\Fgfrl1
1 of 13
No
No
Rnor\Igsf9b
1 of 13
No
No
Rnor\Igsf9
1 of 13
No
No
Rnor\Kirrel1
1 of 13
No
No
Rnor\Kirrel2
1 of 13
No
No
Rnor\Kirrel3
1 of 13
No
No
Rnor\Lrit1
1 of 13
No
No
Rnor\Ncam1
1 of 13
No
No
Rnor\Ncam2
1 of 13
No
No
Rnor\Negr1
1 of 13
No
No
Rnor\Robo1
1 of 13
No
No
Rnor\Sdk2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (14)
Xtro\iglon5
2 of 12
Yes
No
Xtro\lsamp
2 of 12
Yes
No
Xtro\negr1
2 of 12
Yes
No
Xtro\ntm
2 of 12
Yes
No
Xtro\cntn5
1 of 12
No
No
Xtro\dscaml1
1 of 12
No
No
Xtro\dscam
1 of 12
No
No
Xtro\igsf9b
1 of 12
No
No
Xtro\igsf9
1 of 12
No
No
Xtro\kirrel2
1 of 12
No
No
Xtro\lrit3
1 of 12
No
Yes
Xtro\ncam2
1 of 12
No
No
Xtro\opcml
1 of 12
No
No
Xtro\papln
1 of 12
No
No
Danio rerio (Zebrafish) (34)
Drer\negr1
3 of 15
Yes
No
Drer\ntm
2 of 15
No
No
Drer\opcml
2 of 15
No
No
Drer\zgc:110372
2 of 15
No
No
Drer\dscama
1 of 15
No
No
Drer\dscamb
1 of 15
No
No
Drer\dscaml1
1 of 15
No
No
Drer\igsf9a
1 of 15
No
No
Drer\igsf9ba
1 of 15
No
No
Drer\igsf9bb
1 of 15
No
No
Drer\igsf9b
1 of 15
No
No
Drer\itgb4
1 of 15
No
No
Drer\kirrel1b
1 of 15
No
No
Drer\kirrel3a
1 of 15
No
No
Drer\kirrel3b
1 of 15
No
No
Drer\kirrel3l
1 of 15
No
No
Drer\lrit1a
1 of 15
No
Yes
Drer\lrit1b
1 of 15
No
Yes
Drer\lrit3a
1 of 15
No
Yes
Drer\lrit3b
1 of 15
No
No
Drer\lsamp
1 of 15
No
No
Drer\ncam1a
1 of 15
No
No
Drer\ncam1b
1 of 15
No
No
Drer\ncam3
1 of 15
No
No
Drer\paplna
1 of 15
No
No
Drer\ptprq
1 of 15
No
No
Drer\robo4
1 of 15
No
No
Drer\sdk1a
1 of 15
No
No
Drer\sdk1b
1 of 15
No
No
Drer\sdk2a
1 of 15
No
No
Drer\sdk2b
1 of 15
No
No
Drer\si:ch1073-459j12.1
1 of 15
No
No
Drer\si:dkeyp-75h12.2
1 of 15
No
No
Drer\ush2a
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (13)
Cele\wrk-1
8 of 15
Yes
No
Cele\rig-5
2 of 15
No
No
Cele\C53A5.13
1 of 15
No
Yes
Cele\igcm-2
1 of 15
No
No
Cele\lad-2
1 of 15
No
No
Cele\let-805
1 of 15
No
Yes
Cele\rig-3
1 of 15
No
No
Cele\rig-4
1 of 15
No
No
Cele\syg-1
1 of 15
No
No
Cele\zig-2
1 of 15
No
No
Cele\zig-3
1 of 15
No
No
Cele\zig-4
1 of 15
No
No
Cele\zig-8
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919065R )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002086
Drosophila simulans
Dsim\GD11663
Drosophila sechellia
Dsec\GM15904
Drosophila erecta
Dere\GG22184
Drosophila yakuba
Dyak\GE14178
Drosophila ananassae
Dana\GF11886
Drosophila pseudoobscura pseudoobscura
Dpse\GA10289
Drosophila persimilis
Dper\GL17539
Drosophila willistoni
Dwil\GK20814
Drosophila virilis
Dvir\GJ22409
Drosophila mojavensis
Dmoj\GI20556
Drosophila grimshawi
Dgri\GH21362
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915068P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015917
Glossina morsitans
Tsetse fly
Gmor\GMOY001019
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02526
Mayetiola destructor
Hessian fly
Mdes\Mdes016816
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003966
Anopheles darlingi
American malaria mosquito
Adar\ADAC004151
Anopheles gambiae
Malaria mosquito
Agam\AGAP012059
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015836
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0592 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008132
Danaus plexippus
Monarch butterfly
Dple\DPOGS212543-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL014543
Apis florea
Little honeybee
Aflo\4566559540
Apis mellifera
Western honey bee
Amel\GB55370
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17033
Bombus terrestris
Buff-tailed bumblebee
Bter\15214948
Linepithema humile
Argentine ant
Lhum\LH26188
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000b13
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007966
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04557
Tribolium castaneum
Red flour beetle
Tcas\TC003806
Pediculus humanus
Human body louse
Phum\PHUM250180
Rhodnius prolixus
Kissing bug
Rpro\RPRC008951
Cimex lectularius
Bed bug
Clec\CLEC006978
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14109
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06VC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-LsampL_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ig/Fn3f
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-LsampL_1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (53)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG7166
5 of 10
CG34353
5 of 10
klg
5 of 10
Ama
2 of 10
CG13506
2 of 10
DIP-α
2 of 10
DIP-β
2 of 10
DIP-δ
2 of 10
DIP-ε
2 of 10
DIP-η
2 of 10
DIP-γ
2 of 10
DIP-ι
2 of 10
DIP-κ
2 of 10
DIP-θ
2 of 10
DIP-ζ
2 of 10
Lac
2 of 10
babos
1 of 10
bdl
1 of 10
CG33543
1 of 10
DIP-λ
1 of 10
dpr1
1 of 10
dpr2
1 of 10
dpr3
1 of 10
dpr4
1 of 10
dpr5
1 of 10
dpr6
1 of 10
dpr7
1 of 10
dpr8
1 of 10
dpr9
1 of 10
dpr10
1 of 10
dpr11
1 of 10
dpr12
1 of 10
dpr13
1 of 10
dpr14
1 of 10
dpr15
1 of 10
dpr16
1 of 10
dpr17
1 of 10
dpr18
1 of 10
dpr19
1 of 10
dpr20
1 of 10
dpr21
1 of 10
Dscam1
1 of 10
Dscam2
1 of 10
Dscam3
1 of 10
Dscam4
1 of 10
Fas2
1 of 10
fipi
1 of 10
ImpL2
1 of 10
kirre
1 of 10
rst
1 of 10
sdk
1 of 10
Strn-Mlck
1 of 10
tutl
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    wrapper - Nrx-IV
    bead aggregation assay, fluorescence microscopy, inferred by author, anti tag coimmunoprecipitation, western blot
    (Slováková and Carmena, 2011, Stork et al., 2009, Wheeler et al., 2009)
    wrapper - cno
    anti tag coimmunoprecipitation, western blot
    (Slováková and Carmena, 2011)
    wrapper - shg
    anti bait coimmunoprecipitation, western blot
    (Slováková and Carmena, 2011)
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map

    2-99

    Cytogenetic map
    58D4-58D4
    Sequence location
    2R:22,379,637..22,382,675 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    58D4-58D4
    Limits computationally determined from genome sequence between P{lacW}l(2)k09801k09801 and P{lacW}l(2)k13211k13211&P{EP}EP827
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    58D6-58D6
    (determined by in situ hybridisation)
    (Noordermeer et al., 1998)
    Experimentally Determined Recombination Data
    Location

    2-99

    (FlyBase, 2016)

    2-104.1

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (5)
    Genomic Clones (17)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (18)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      monoclonal, polyclonal

      (Noordermeer et al., 1998)
      Commercially Available Antibodies
       
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: wrapper CG10382

      (Milshina, 1999.11)
      Source for database merge of
      Additional comments
      Other Comments

      The midline glia migrate normally in wrapper mutant embryos, but they do not ensheath the commissural axons, and as a result die.

      (Noordermeer et al., 1998)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 37 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      Synonyms and Secondary IDs (5)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (91)