FlyBase Gene Report: Dmel\wrapper

embryonic/larval brain

(Noordermeer et al., 1998)

ventral midline

(Noordermeer et al., 1998)

PNS glial cell

(Noordermeer et al., 1998)

embryonic stage 17

glial cell of embryonic brain

(Noordermeer et al., 1998)

(Wheeler et al., 2006)

embryonic stage 12 -- 17

dorsal sensory complex proper primordium

(Noordermeer et al., 1998)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

midline primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic central brain neuron

(Fisher et al., 2012)

embryonic/larval lymph gland

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

midline ventral glial cell

(Fisher et al., 2012)

sensory nervous system primordium

(Fisher et al., 2012)

ventral midline

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

ventral sensory complex primordium

(Fisher et al., 2012)

posterior midline glial cell

(Kearney et al., 2004)

embryonic stage 11

(Wheeler et al., 2006)

posterior midline glial cell

(Wheeler et al., 2006)

embryonic stage 13

(Wheeler et al., 2006)

(Wheeler et al., 2006)

embryonic stage 9 -- 12

midline primordium | subset

(Kearney et al., 2004)

embryonic stage 12

posterior midline glial cell

Comment: high level

(Watson et al., 2011)

Comment: low level

(Watson et al., 2011)

Additional Descriptive Data

wrapper is expressed at a high level in anterior midline glia and at a low level in posterior midline glia in stage 12 embryos.

(Watson et al., 2011)

Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.

(Wheeler et al., 2006)

wrapper transcripts are first detected in stage 12 embryos in the midline glia. They are most prominent on two pairs of midline glia, MGA and MGM, but are also observed at a lower level on the third pair, MGP. They persist until the end of embryogenesis. By stage 17, they are also observed at a low level on some lateral glia and on glia throughout the embryonic brain. wrapper transcripts are observed in third instar larvae along the midline and throughout the brain. Weak expression is observed in the glia supporting the chordotonal s nsory organs of the PNS.

(Noordermeer et al., 1998)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 17

glial cell of embryonic brain

(Noordermeer et al., 1998)

ventral midline

(Noordermeer et al., 1998)

embryonic/larval brain

(Noordermeer et al., 1998)

embryonic stage 12 -- 17

(Noordermeer et al., 1998)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

wrapper protein is first detected in stage 12 embryos in the midline glia. It is most prominent on two pairs of midline glia, MGA and MGM, but is also observed at a lower level on the third pair, MGP. It persists until the end of embryogenesis. By stage 17, it is also observed at a low level on some lateral glia and on glia throughout the embryonic brain. wrapper protein is observed in third instar larvae along the midline and throughout the brain. Weak expression is observed in the glia supporting the chordotonal sensory organs of t e PNS.

(Noordermeer et al., 1998)

Marker for

(Bashaw et al., 2001)

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{GMR54H02-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

embryonic/larval neuron | subset

(Banerjee et al., 2017)

(Banerjee et al., 2017)

embryonic/larval CNS subperineurial glial cell

(Coutinho-Budd et al., 2017)

ventral nerve cord | restricted

(Coutinho-Budd et al., 2017)

(Coutinho-Budd et al., 2017)

embryonic/larval Malpighian tubule

(Coutinho-Budd et al., 2017)

optic-lobe-associated cortex glial cell

(Coutinho-Budd et al., 2017)

adult stage

adult cell body glial cell

(Coutinho-Budd et al., 2017)

Reporter: P{wrapper-GAL4.CH321-61P08}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 16

(Banerjee et al., 2017)

(Banerjee et al., 2017)

Reporter: P{wrapper-GAL4.DBD.932i}

Stage

Tissue/Position (including subcellular localization)

Reference

Comment: when combined with P{nrv2-VP16.AD}

(Coutinho-Budd et al., 2017)

embryonic stage 12

Comment: when combined with P{nrv2-VP16.AD}

(Coutinho-Budd et al., 2017)

embryonic stage 15

first instar larval stage

Comment: when combined with P{nrv2-VP16.AD}

(Coutinho-Budd et al., 2017)

second instar larval stage

Comment: when combined with P{nrv2-VP16.AD}

(Coutinho-Budd et al., 2017)

adult cell body glial cell

Comment: when combined with P{nrv2-VP16.AD}

(Coutinho-Budd et al., 2017)

adult stage

Comment: when combined with P{nrv2-VP16.AD}

(Coutinho-Budd et al., 2017)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\wrapper in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\wrapper

View exonic expression by tissue for Dmel\wrapper

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025878

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0025878

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG10382-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10382

Flygut - An atlas of the Drosophila adult midgut

FBgn0025878

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\wrapper

Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 13 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of wrapper

Transgenic constructs containing regulatory region of wrapper

Deletions and Duplications ( 2 )

Disrupted in

Df(2R)02311

(Noordermeer et al., 1998)

Df(2R)X58-5

(Noordermeer et al., 1998)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

wrapper^f02069

Sterility

Allele

fertile

wrapper^f02069

Other Phenotypes

Allele

majority die during embryonic stage | recessive

wrapper^R175

Phenotype manifest in

Allele