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Gene Dmel\wrapper

General Information
Symbol	Dmel\wrapper	Species	D. melanogaster
Name	wrapper	Annotation symbol	CG10382
Feature type	protein_coding_gene	FlyBase ID	FBgn0025878
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	58D4-58D4	Sequence location	2R:18,267,142..18,270,180 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene wrapper is referred to in FlyBase by the symbol Dmel\wrapper (CG10382, FBgn0025878). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: nervous system development; gliogenesis; axonogenesis. 18 alleles are reported. The phenotypes of these alleles are annotated with: ventral nerve cord commissure; midline glial cell; presumptive embryonic/larval central nervous system. It has one annotated transcript and one annotated polypeptide. Protein features are: Fibronectin, type III; Immunoglobulin I-set; Immunoglobulin V-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like domain; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1622923_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of wrapper. Gene sequence location is 2R:18267017..18270191.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58D4-58D4   Limits computationally determined from genome sequence between P{lacW}l(2)k09801k09801 and P{lacW}l(2)k13211k13211&P{EP}EP827
Experimentally Determined Cytological Location
Cytogenetic map Notes References 58D6-58D6   (determined by in situ hybridisation)   (Noordermeer et al., 1998)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\wrapper for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) wrapper-RA FBtr0071821  NM_058056   1977   500
Additional Transcript Data & Comments
Reported size (kB)	2.0 (northern blot) (Noordermeer et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein wrapper-PA   FBpp0071732   55.5   500   5.96     NP_477404   AAF46838
Additional Polypeptide Data & Comments
Reported size (kDa)	500 (aa) (Noordermeer et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like domain (IPR007110) Immunoglobulin V-set (IPR013106) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF46838   AC005714   AF134113 AAD24192   AI063360   AW940122   AY047524 AAK77256   AY070893   BI356615   BI617594   BI627117   CO291947   CO294471   CO316380   CO320719   CO325630   CO328023   EC063459   EC069002   EC072506   EC077961   EC201369   EC224038   EC251597
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W260 Q9XZB7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) midline primordium   (Fisher et al., 2012) embryonic stage 12 -- 17   midline glial cell   (Noordermeer et al., 1998) embryonic stage 13 -- 16   dorsal sensory complex proper primordium   (Fisher et al., 2012) Comment:reported as dorsal/lateral sensory complexes embryonic brain   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic/larval lymph gland   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) midline ventral glial cell   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012) embryonic stage 17   glial cell of embryonic brain   (Noordermeer et al., 1998) third instar larval stage   embryonic/larval brain   (Noordermeer et al., 1998) ventral midline   (Noordermeer et al., 1998) PNS glial cell   (Noordermeer et al., 1998)
Additional Descriptive Data
	wrapper transcripts are first detected in stage 12 embryos in the midline glia. They are most prominent on two pairs of midline glia, MGA and MGM, but are also observed at a lower level on the third pair, MGP. They persist until the end of embryogenesis. By stage 17, they are also observed at a low level on some lateral glia and on glia throughout the embryonic brain. wrapper transcripts are observed in third instar larvae along the midline and throughout the brain. Weak expression is observed in the glia supporting the chordotonal s nsory organs of the PNS. (Noordermeer et al., 1998)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12 -- 17   midline glial cell   (Noordermeer et al., 1998) embryonic stage 17   glial cell of embryonic brain   (Noordermeer et al., 1998) third instar larval stage   ventral midline   (Noordermeer et al., 1998) embryonic/larval brain   (Noordermeer et al., 1998)
Additional Descriptive Data
	wrapper protein is first detected in stage 12 embryos in the midline glia. It is most prominent on two pairs of midline glia, MGA and MGM, but is also observed at a lower level on the third pair, MGP. It persists until the end of embryogenesis. By stage 17, it is also observed at a low level on some lateral glia and on glia throughout the embryonic brain. wrapper protein is observed in third instar larvae along the midline and throughout the brain. Weak expression is observed in the glia supporting the chordotonal sensory organs of t e PNS. (Noordermeer et al., 1998)
Marker for
	midline glial cell
Subcellular Localization (GO Cellular Component)
CV term Evidence References
plasma membrane inferred from direct assay (Khanna et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    660.875 Larval Midgut    3.7 Larval Hindgut    5.6 Larval Malpighian Tubules    6 Larval Fat Body    4.6 Larval Salivary Gland    2.4 Larval Trachea    4.05 Larval Carcass    4.65 Adult Head    84.9 Adult Eye    36.475 Adult Brain    227.9 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    4.2 Adult Midgut    3.1 Adult Hindgut    4.9 Adult Malpighian Tubules    7.3 Adult Fat Body    7.2 Adult Salivary Gland    5.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    2.3 Adult Testis    2.6 Adult Male Accessory Gland    4.8 Adult Carcass    5.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (660.875) Larval Midgut    3.7 Larval Hindgut    5.6 Larval Malpighian Tubules    6 Larval Fat Body    4.6 Larval Salivary Gland    2.4 Larval Trachea    4.05 Larval Carcass    4.65 Adult Head    84.9 Adult Eye    36.475 Adult Brain    227.9 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    4.2 Adult Midgut    3.1 Adult Hindgut    4.9 Adult Malpighian Tubules    7.3 Adult Fat Body    7.2 Adult Salivary Gland    5.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    2.3 Adult Testis    2.6 Adult Male Accessory Gland    4.8 Adult Carcass    5.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    660.875 Larval Midgut    3.7 Larval Hindgut    5.6 Larval Malpighian Tubules    6 Larval Fat Body    4.6 Larval Salivary Gland    2.4 Larval Trachea    4.05 Larval Carcass    4.65 Adult Head    84.9 Adult Eye    36.475 Adult Brain    227.9 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    4.2 Adult Midgut    3.1 Adult Hindgut    4.9 Adult Malpighian Tubules    7.3 Adult Fat Body    7.2 Adult Salivary Gland    5.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    2.3 Adult Testis    2.6 Adult Male Accessory Gland    4.8 Adult Carcass    5.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    660.875 Larval Midgut    3.7 Larval Hindgut    5.6 Larval Malpighian Tubules    6 Larval Fat Body    4.6 Larval Salivary Gland    2.4 Larval Trachea    4.05 Larval Carcass    4.65 Adult Head    84.9 Adult Eye    36.475 Adult Brain    227.9 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    4.2 Adult Midgut    3.1 Adult Hindgut    4.9 Adult Malpighian Tubules    7.3 Adult Fat Body    7.2 Adult Salivary Gland    5.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    2.3 Adult Testis    2.6 Adult Male Accessory Gland    4.8 Adult Carcass    5.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    660.875 Larval Midgut    3.7 Larval Hindgut    5.6 Larval Malpighian Tubules    6 Larval Fat Body    4.6 Larval Salivary Gland    2.4 Larval Trachea    4.05 Larval Carcass    4.65 Adult Head    84.9 Adult Eye    36.475 Adult Brain    227.9 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    4.2 Adult Midgut    3.1 Adult Hindgut    4.9 Adult Malpighian Tubules    7.3 Adult Fat Body    7.2 Adult Salivary Gland    5.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    2.3 Adult Testis    2.6 Adult Male Accessory Gland    4.8 Adult Carcass    5.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  660.875 Larval Midgut    3.7 Larval Hindgut    5.6 Larval Malpighian Tubules    6 Larval Fat Body    4.6 Larval Salivary Gland    2.4 Larval Trachea    4.05 Larval Carcass    4.65 Adult Head    84.9 Adult Eye    36.475 Adult Brain    227.9 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    4.2 Adult Midgut    3.1 Adult Hindgut    4.9 Adult Malpighian Tubules    7.3 Adult Fat Body    7.2 Adult Salivary Gland    5.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    2.3 Adult Testis    2.6 Adult Male Accessory Gland    4.8 Adult Carcass    5.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    660.875 Larval Midgut    3.7 Larval Hindgut    5.6 Larval Malpighian Tubules    6 Larval Fat Body    4.6 Larval Salivary Gland    2.4 Larval Trachea    4.05 Larval Carcass    4.65 Adult Head    84.9 Adult Eye    36.475 Adult Brain    227.9 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    4.2 Adult Midgut    3.1 Adult Hindgut    4.9 Adult Malpighian Tubules    7.3 Adult Fat Body    7.2 Adult Salivary Gland    5.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    2.3 Adult Testis    2.6 Adult Male Accessory Gland    4.8 Adult Carcass    5.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    660.875 Larval Midgut    3.7 Larval Hindgut    5.6 Larval Malpighian Tubules    6 Larval Fat Body    4.6 Larval Salivary Gland    2.4 Larval Trachea    4.05 Larval Carcass    4.65 Adult Head    84.9 Adult Eye    36.475 Adult Brain    227.9 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    4.2 Adult Midgut    3.1 Adult Hindgut    4.9 Adult Malpighian Tubules    7.3 Adult Fat Body    7.2 Adult Salivary Gland    5.4 Adult Heart    1.95 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    6.9 Adult Ovary    2.3 Adult Testis    2.6 Adult Male Accessory Gland    4.8 Adult Carcass    5.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    84.9   NA  Eye    36.475   NA  Brain    227.9   660.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    372.6   NA  Crop    4.2   3.7  Midgut    3.1   5.6  Hindgut    4.9   6  Malpighian Tubules    7.3   4.6  Fat Body    7.2   2.4  Salivary Gland    5.4   NA  Heart    1.95   4.05  Trachea    NA   NA  VirginFemale Spermatheca    4.9   NA  InseminatedFemale Spermatheca    6.9   NA  Ovary    2.3   NA  Testis    2.6   NA  Male Accessory Gland    4.8   4.65  Carcass    5.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    66 central nervous system, pupae P8    18 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    19 head, mated 1-day female    10 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male    27 head, mated 20-day male    41 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3  (66) central nervous system, pupae P8    18 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    19 head, mated 1-day female    10 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male  (27) head, mated 20-day male  (41) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    66 central nervous system, pupae P8    18 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    19 head, mated 1-day female    10 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male    27 head, mated 20-day male    41 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    66 central nervous system, pupae P8    18 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    19 head, mated 1-day female    10 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male    27 head, mated 20-day male    41 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    66 central nervous system, pupae P8    18 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    19 head, mated 1-day female    10 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male    27 head, mated 20-day male    41 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3  (66) central nervous system, pupae P8    18 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    19 head, mated 1-day female    10 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male  27 head, mated 20-day male  (41) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    66 central nervous system, pupae P8    18 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    19 head, mated 1-day female    10 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male    27 head, mated 20-day male    41 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    66 central nervous system, pupae P8    18 head, virgin 1-day female    13 head, virgin 4-day female    12 head, virgin 20-day female    19 head, mated 1-day female    10 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male    27 head, mated 20-day male    41 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr    43 embryo 12-14hr    25 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    12 white prepupae 24hr    16 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr  (43) embryo 12-14hr    25 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    12 white prepupae 24hr    16 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr    43 embryo 12-14hr    25 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    12 white prepupae 24hr    16 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr    43 embryo 12-14hr    25 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    12 white prepupae 24hr    16 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr    43 embryo 12-14hr    25 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    12 white prepupae 24hr    16 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr  (43) embryo 12-14hr    25 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    12 white prepupae 24hr    16 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr    43 embryo 12-14hr    25 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    12 white prepupae 24hr    16 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr    43 embryo 12-14hr    25 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    12 white prepupae 24hr    16 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    33 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    98 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    27 ovary OSC    83 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8  (33) wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21  (29) wing disc ML-DmD32    0 haltere disc ML-DmD17-c3  (46) eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1  (98) CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS  (27) ovary OSC  (83) ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    33 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    98 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    27 ovary OSC    83 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    33 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    98 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    27 ovary OSC    83 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    33 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    98 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    27 ovary OSC    83 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8  (33) wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21  29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3  (46) eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1  (98) CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS  27 ovary OSC  (83) ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    33 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    98 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    27 ovary OSC    83 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    33 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    98 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    27 ovary OSC    83 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • GH03113 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025878 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10382-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for wrapper Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable wrapperf02069 Sterility Allele fertile wrapperf02069 Phenotype manifest in Allele midline glial cell wrapperunspecified midline glial cell, with Scer\GAL4elav.PLu wrapperScer\UAS.cNa midline glial cell, with Scer\GAL4sca-537.4 wrapperScer\UAS.cNa presumptive embryonic/larval central nervous system, with Scer\GAL4elav.PLu wrapperScer\UAS.cNa presumptive embryonic/larval central nervous system, with Scer\GAL4sca-537.4 wrapperScer\UAS.cNa ventral nerve cord commissure wrapperE4 wrapperR174 wrapperR175 wrapperR22 wrapperR47 ventral nerve cord commissure, with Scer\GAL4elav.PLu wrapperScer\UAS.cNa ventral nerve cord commissure, with Scer\GAL4sca-537.4 wrapperScer\UAS.cNa
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of wrapper Class Mutagen Stocks Known lesion wrapperf02069 piggyBac transposase 2 -- wrapper173 P-element activity 0 Yes wrapperE12 P-element activity 0 Yes wrapperE221 P-element activity 0 Yes wrapperE2 P-element activity 0 Yes wrapperE4 P-element activity 0 Yes wrapperP23 P-element activity 0 Yes wrapperP58 P-element activity 0 Yes wrapperR174 P-element activity 0 Yes wrapperR175 P-element activity 0 Yes wrapperR22 P-element activity 0 Yes wrapperR47 P-element activity 0 Yes wrapperunspecified 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of wrapper Class Mutagen Stocks Known lesion wrapperJF03240 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wrapperKK110639 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wrapperGD5903 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes wrapperNIG.10382R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes wrapperScer\UAS.cNa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)02311 (Noordermeer et al., 1998) Df(2R)X58-5 (Noordermeer et al., 1998)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5903} NA P{KK110639} NA P{NIG.10382R} NA P{TRiP.JF03240} NA P{UAS-wrapper.N} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}wrapperf02069 NA insertion of enhancer trap P{PZ}wrapperP23 No P{PZ}wrapperP58 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axonogenesis inferred from mutant phenotype (Noordermeer et al., 1998) gliogenesis inferred from mutant phenotype (Noordermeer et al., 1998) nervous system development inferred from expression pattern (Noordermeer et al., 1998)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Khanna et al., 2010)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
extrinsic to plasma membrane inferred from sequence or structural similarity with EMBL:X93601 (Noordermeer et al., 1998)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions wrapper allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0025878
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG60CJ2R Dipteran inclusive ortholog search EOG634WFH Insect inclusive ortholog search EOG6D25KM Arthropod inclusive ortholog search EOG6RFJ7V Metazoa inclusive ortholog search EOG6JHR7X
Orthologs in Drosophila Species (EOG60CJ2R)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\wrapper     Drosophila simulans   Dsim\GD11663 Y   Drosophila sechellia   Dsec\GM15904 Y   Drosophila erecta   Dere\GG22184 Y   Drosophila yakuba   Dyak\GE14178 Y   Drosophila ananassae   Dana\GF11886 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10289 Y   Drosophila persimilis   Dper\GL17539 Y   Drosophila willistoni   Dwil\GK20814 Y   Drosophila virilis   Dvir\GJ22409 Y   Drosophila mojavensis   Dmoj\GI20556 Y   Drosophila grimshawi   Dgri\GH21362 Y
Orthologs in non-Drosophila Dipterans (EOG634WFH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003966   Anopheles gambiae Malaria mosquito  Agam\AGAP012059   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015836
Orthologs in non-Dipteran Insects (EOG6D25KM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB55370   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007966   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11041   Atta cephalotes Leafcutter ant  Acep\ACEP19999   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14898   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21575   Linepithema humile Argentine ant  Lhum\LH26188   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25962   Solenopsis invicta Red fire ant  Sinv\SINV10087   Pediculus humanus Human body louse  Phum\PHUM250180   Tribolium castaneum Red flour beetle  Tcas\TC003806
Orthologs in non-Insect Arthropods (EOG6RFJ7V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_328903 Y Ixodes scapularis Deer tick  Isca\ISCW015846 Y Ixodes scapularis Deer tick  Isca\ISCW007116 Y Ixodes scapularis Deer tick  Isca\ISCW015844 Y Ixodes scapularis Deer tick  Isca\ISCW015847 Y Ixodes scapularis Deer tick  Isca\ISCW015845 Y
Orthologs in non-Arthropod Metazoa (EOG6JHR7X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005084gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008435gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024613gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005900gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015903gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007824gn Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11663 Drosophila sechellia Dsec\GM15904 Drosophila erecta Dere\GG22184 Drosophila yakuba Dyak\GE14178 Drosophila ananassae Dana\GF11886 Drosophila pseudoobscura pseudoobscura Dpse\GA10289 Drosophila persimilis Dper\GL17539 Drosophila willistoni Dwil\GK20814 Drosophila virilis Dvir\GJ22409 Drosophila mojavensis Dmoj\GI20556 Drosophila grimshawi Dgri\GH21362
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	29561 y1 v1; P{TRiP.JF03240}attP2 18511 w1118; PBac{WH}wrapperf02069
Harvard	- PBac{WH}wrapperf02069
VDRC	v105314 P{KK110639}VIE-260B
Genomic Clones ( 2 )
	BACR02I11 BACR48M13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH03113 LP01670
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE42803 RH47973 RH68330
Other clones	15877 69531 71002 75051 161070 214377.2 CK01.30B.F6 EK196954 EK198839 EK207022 EK264761 EK287502 EP08436
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025878 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37555
Antibody Information
	monoclonal, polyclonal (Noordermeer et al., 1998)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: wrapper CG10382 (Milshina, 1999.11)
Source for database merge of
Additional comments
Other Comments
	The midline glia migrate normally in wrapper mutant embryos, but they do not ensheath the commissural axons, and as a result die. (Noordermeer et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058056 RefSeq (Proteins) • NP_477404 DDBJ / EMBL / GenBank • AAD24192 AAF46838 AAK77256 AC005714 AF134113 AI063360 AW940122 AY047524 Entrez Gene - A searchable database of RefSeq genes. • 37555 UniProtKB/TrEMBL • Q9W260 Q9XZB7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like domain (IPR007110) Immunoglobulin V-set (IPR013106) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH03113
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0025878 DRSC - Results from RNAi screens. • FBgn0025878 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025878 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10382-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025878 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37555 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/wrapper.htm modMine - Data generated by the modENCODE project. • FBgn0025878
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG10382 (Klebes et al., 2005, Keleman et al., 2009.8.5, Perkins et al., 2009, Khanna et al., 2010) CT19059 (Hynes and Zhao, 2000) Wr (Learte et al., 2008) wrapper (Wheeler et al., 2006, Wheeler et al., 2012, Hueber et al., 2007, Schimmelpfeng et al., 2006, Zhang et al., 2011, Wheeler et al., 2009, Wheeler et al., 2009, Fulkerson and Estes, 2011, Ge et al., 2012, Japanese National Institute of Genetics, 2012.5.21) Wrapper (Zhang et al., 2011)
Name Synonym	wrapper (Estes et al., 2008, Schimmelpfeng et al., 2006, Slováková and Carmena, 2011, Wheeler et al., 2008, Stagg et al., 2011, Cook and Matthews, 2009.12.17, Watson et al., 2011, Fulkerson and Estes, 2011) Wrapper (Schreader et al., 2010, Hsouna et al., 2003, Miller et al., 2008, Wouda et al., 2008, Stork et al., 2009, Khanna et al., 2010, Hsouna and VanBerkum, 2008, Malartre et al., 2010, Learte et al., 2008, Mast et al., 2011)
Secondary FlyBase IDs
References ( 66 )
Generate a list of	All references relating to this gene ( 66 )
List References by type	Research paper  ( 44 ) Supplementary material  ( 6 ) Review  ( 4 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 )
Recent research papers ( 9 )
	Ge et al., 2012, Cell Death Differ. 19(5): 839--846 Overlapping functions of microRNAs in control of apoptosis during Drosophila embryogenesis. [FBrf0217965] Wheeler et al., 2012, Dev. Biol. 361(2): 232--244 Time-lapse imaging reveals stereotypical patterns of Drosophila midline glial migration. [FBrf0217061] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Fulkerson and Estes, 2011, J. Exp. Zool. B Mol. Dev. Evol. 316B(1): 61--75 Common motifs shared by conserved enhancers of Drosophila midline glial genes. [FBrf0212527] Mast et al., 2011, Dis. Model Mech. 4(5): 659--672 A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders. [FBrf0215017] Slováková and Carmena, 2011, Development 138(8): 1563--1571 Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactions. [FBrf0213315] Stagg et al., 2011, Development 138(11): 2171--2183 Dual role for Drosophila lethal of scute in CNS midline precursor formation and dopaminergic neuron and motoneuron cell fate. [FBrf0213671] Watson et al., 2011, Development 138(7): 1285--1295 Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates. [FBrf0213237] Zhang et al., 2011, PLoS ONE 6(10): e26197 Mastermind Mutations Generate a Unique Constellation of Midline Cells within the Drosophila CNS. [FBrf0216654] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...