Immunoglobulin domain ligand - present in midline glia - required, along with neuronally-expressed Neurexin IV, for ensheathment of commissural axons
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Gene model reviewed during 5.51
2.0 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
500 (aa)
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Comment: reported as dorsal/lateral sensory complexes
Comment: high level
Comment: low level
wrapper is expressed at a high level in anterior midline glia and at a low level in posterior midline glia in stage 12 embryos.
Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.
wrapper transcripts are first detected in stage 12 embryos in the midline glia. They are most prominent on two pairs of midline glia, MGA and MGM, but are also observed at a lower level on the third pair, MGP. They persist until the end of embryogenesis. By stage 17, they are also observed at a low level on some lateral glia and on glia throughout the embryonic brain. wrapper transcripts are observed in third instar larvae along the midline and throughout the brain. Weak expression is observed in the glia supporting the chordotonal s nsory organs of the PNS.
wrapper protein is first detected in stage 12 embryos in the midline glia. It is most prominent on two pairs of midline glia, MGA and MGM, but is also observed at a lower level on the third pair, MGP. It persists until the end of embryogenesis. By stage 17, it is also observed at a low level on some lateral glia and on glia throughout the embryonic brain. wrapper protein is observed in third instar larvae along the midline and throughout the brain. Weak expression is observed in the glia supporting the chordotonal sensory organs of t e PNS.
Comment: when combined with P{nrv2-VP16.AD}
Comment: when combined with P{nrv2-VP16.AD}
Comment: when combined with P{nrv2-VP16.AD}
Comment: when combined with P{nrv2-VP16.AD}
Comment: when combined with P{nrv2-VP16.AD}
Comment: when combined with P{nrv2-VP16.AD}
GBrowse - Visual display of RNA-Seq signals
View Dmel\wrapper in GBrowse 22-99
2-99
2-104.1
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal, polyclonal
Source for identity of: wrapper CG10382
The midline glia migrate normally in wrapper mutant embryos, but they do not ensheath the commissural axons, and as a result die.