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Gene Dmel\Timp

General Information
Symbol	Dmel\Timp	Species	D. melanogaster
Name	Tissue inhibitor of metalloproteases	Annotation symbol	CG6281
Feature type	protein_coding_gene	FlyBase ID	FBgn0025879
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	Dtimp
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	86A1-86A1	Sequence location	3R:6,029,597..6,038,729 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Tissue inhibitor of metalloproteases is referred to in FlyBase by the symbol Dmel\Timp (CG6281, FBgn0025879). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: metalloendopeptidase inhibitor activity. There is experimental evidence that it is involved in the biological process: tracheal pit formation in open tracheal system; wing disc morphogenesis; phototaxis; delamination; imaginal disc-derived wing expansion; tracheal outgrowth, open tracheal system; cell adhesion; basement membrane organization. 8 alleles are reported. The phenotypes of these alleles are annotated with: dorsal air sac; adult abdomen; embryonic/larval dorsal trunk; wing. It has one annotated transcript and one annotated polypeptide. Protein features are: Netrin domain; Proteinase inhibitor I35, tissue inhibitor of metalloproteinase; Tissue inhibitor of metalloproteinases-like, OB-fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, adult hindgut, adult heart, adult fat body, adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, adult midgut, larval hindgut, adult Malpighian tubules, adult testis. Gene sequence location is 3R:6029597..6038729.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86A1-86A1   Limits computationally determined from genome sequence between P{EP}Fmr1EP3517&P{PZ}tws02414 and P{PZ}jumu06439&P{lacW}l(3)j8B6j8B6
Experimentally Determined Cytological Location
Cytogenetic map Notes References 86A-86A     (Buchner, 1998.8.12)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Timp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Timp-RB FBtr0082245  NM_169336   1591   210
Additional Transcript Data & Comments
Reported size (kB)	1.5 (northern blot) (Pohar et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Timp-PB   FBpp0081722   24.0   210   9.84     NP_731461   AAN13465
Additional Polypeptide Data & Comments
Reported size (kDa)	210 (aa) (Pohar et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Netrin domain (IPR001134) Proteinase inhibitor I35, tissue inhibitor of metalloproteinase (IPR001820) Tissue inhibitor of metalloproteinases-like, OB-fold (IPR008993) Proteinase inhibitor I35, tissue inhibitor of metalloproteinase, C-terminal domain (IPR027465)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAN13465   AI406008   AJ010067 CAA08989   AW941882   AY069211 AAL39356   BI590167   BI606370   CA803771   CA806267   CA807150   CO267334   CO339164   ES689852   EV591998   GH980124
UniProtKB/Swiss-Prot	Q9VH14
UniProtKB/TrEMBL	A4V2N5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) embryonic labial sensory complex   (Fisher et al., 2012) embryonic/larval dorsal vessel   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference pupal stage   salivary gland   (Lee et al., 2003)
Additional Descriptive Data
	Transcript is detected in pupal salivary glands prior to the time of head eversion. The expression of this gene is repressed in this tissue at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue. (Lee et al., 2003)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
dendrite inferred from mutant phenotype (Kuo et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, adult hindgut, adult heart, adult fat body, adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, adult midgut, larval hindgut, adult Malpighian tubules, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    11 head, virgin 4-day female    16 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    15 head, mated 20-day female    14 head, mated 1-day male    20 head, mated 4-day male    25 head, mated 20-day male    42 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    25 carcass, larvae L3 wandering    10 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    5 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    11 head, virgin 4-day female    16 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    15 head, mated 20-day female    14 head, mated 1-day male    20 head, mated 4-day male    25 head, mated 20-day male  (42) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    25 carcass, larvae L3 wandering    10 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    5 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    11 head, virgin 4-day female    16 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    15 head, mated 20-day female    14 head, mated 1-day male    20 head, mated 4-day male    25 head, mated 20-day male    42 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    25 carcass, larvae L3 wandering    10 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    5 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    11 head, virgin 4-day female    16 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    15 head, mated 20-day female    14 head, mated 1-day male    20 head, mated 4-day male    25 head, mated 20-day male    42 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    25 carcass, larvae L3 wandering    10 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    5 accessory gland, mated 4-day male    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    11 head, virgin 4-day female    16 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    15 head, mated 20-day female    14 head, mated 1-day male    20 head, mated 4-day male    25 head, mated 20-day male    42 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    25 carcass, larvae L3 wandering    10 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    5 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    11 head, virgin 4-day female    16 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    15 head, mated 20-day female    14 head, mated 1-day male    20 head, mated 4-day male    25 head, mated 20-day male  (42) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    25 carcass, larvae L3 wandering    10 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    5 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    11 head, virgin 4-day female    16 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    15 head, mated 20-day female    14 head, mated 1-day male    20 head, mated 4-day male    25 head, mated 20-day male    42 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    25 carcass, larvae L3 wandering    10 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    5 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    11 head, virgin 4-day female    16 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    15 head, mated 20-day female    14 head, mated 1-day male    20 head, mated 4-day male    25 head, mated 20-day male    42 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    25 carcass, larvae L3 wandering    10 carcass, 1-day adult    15 carcass, 4-day adult    18 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    5 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during early pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    14 embryo 16-18hr    25 embryo 18-20hr    30 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    6 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    20 white prepupae 12hr    51 white prepupae 24hr    12 pupae 2d postWPP    32 pupae 3d postWPP    37 pupae 4d postWPP    37 adult male 01day    43 adult male 05day    46 adult male 30day    52 adult female 01day    24 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    14 embryo 16-18hr    25 embryo 18-20hr  (30) embryo 20-22hr    11 embryo 22-24hr    16 larva L1    6 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    20 white prepupae 12hr  (51) white prepupae 24hr    12 pupae 2d postWPP  (32) pupae 3d postWPP  (37) pupae 4d postWPP  (37) adult male 01day  (43) adult male 05day  (46) adult male 30day  (52) adult female 01day    24 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    14 embryo 16-18hr    25 embryo 18-20hr    30 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    6 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    20 white prepupae 12hr    51 white prepupae 24hr    12 pupae 2d postWPP    32 pupae 3d postWPP    37 pupae 4d postWPP    37 adult male 01day    43 adult male 05day    46 adult male 30day    52 adult female 01day    24 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    14 embryo 16-18hr    25 embryo 18-20hr    30 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    6 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    20 white prepupae 12hr    51 white prepupae 24hr    12 pupae 2d postWPP    32 pupae 3d postWPP    37 pupae 4d postWPP    37 adult male 01day    43 adult male 05day    46 adult male 30day    52 adult female 01day    24 adult female 05day    19 adult female 30day    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    14 embryo 16-18hr    25 embryo 18-20hr    30 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    6 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    20 white prepupae 12hr    51 white prepupae 24hr    12 pupae 2d postWPP    32 pupae 3d postWPP    37 pupae 4d postWPP    37 adult male 01day    43 adult male 05day    46 adult male 30day    52 adult female 01day    24 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    14 embryo 16-18hr    25 embryo 18-20hr  30 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    6 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    20 white prepupae 12hr  (51) white prepupae 24hr    12 pupae 2d postWPP  32 pupae 3d postWPP  (37) pupae 4d postWPP  (37) adult male 01day  (43) adult male 05day  (46) adult male 30day  (52) adult female 01day    24 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    14 embryo 16-18hr    25 embryo 18-20hr    30 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    6 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    20 white prepupae 12hr    51 white prepupae 24hr    12 pupae 2d postWPP    32 pupae 3d postWPP    37 pupae 4d postWPP    37 adult male 01day    43 adult male 05day    46 adult male 30day    52 adult female 01day    24 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    14 embryo 16-18hr    25 embryo 18-20hr    30 embryo 20-22hr    11 embryo 22-24hr    16 larva L1    6 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    20 white prepupae 12hr    51 white prepupae 24hr    12 pupae 2d postWPP    32 pupae 3d postWPP    37 pupae 4d postWPP    37 adult male 01day    43 adult male 05day    46 adult male 30day    52 adult female 01day    24 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    5 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    78 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    0 ovary fGS/OSS    76 ovary OSC    13 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    5 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1  (78) CNS ML-DmBG2-c2  (34) tumorous blood cells mbn2    0 ovary fGS/OSS  (76) ovary OSC    13 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    5 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    78 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    0 ovary fGS/OSS    76 ovary OSC    13 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    5 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    78 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    0 ovary fGS/OSS    76 ovary OSC    13 ovary OSS    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    5 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    78 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    0 ovary fGS/OSS    76 ovary OSC    13 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    5 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1  (78) CNS ML-DmBG2-c2  (34) tumorous blood cells mbn2    0 ovary fGS/OSS  (76) ovary OSC    13 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    5 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    78 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    0 ovary fGS/OSS    76 ovary OSC    13 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    2 embryonic S1    0 embryonic S3    5 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    78 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    0 ovary fGS/OSS    76 ovary OSC    13 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	BDGP expression data • GH26186 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025879 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6281-RB;CG6281-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Timp Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4dpp.PH TimpScer\UAS.cPa partially lethal - majority die | larval stage TimpScer\UAS.cPa partially lethal - majority die | larval stage, with Scer\GAL4btl.PS TimpScer\UAS.cPa partially lethal - majority die | larval stage, with Scer\GAL4dpp.PH TimpScer\UAS.cPa partially lethal - majority die | pupal stage, with Scer\GAL4btl.PS TimpScer\UAS.cPa partially lethal - majority live TimpP1+P2 partially lethal - majority live | cold sensitive Timp28 viable, with Scer\GAL4pnr-MD237 TimpGD4783 Sterility Allele semi-fertile | cold sensitive Timp28 Other Phenotypes Allele neuroanatomy defective | pupal stage, with Scer\GAL4ppk.PG TimpScer\UAS.cPa phototaxis defective Timp28 visible, with Scer\GAL4Lsp2.PH TimpScer\UAS.cSa visible, with Scer\GAL4Ubx-lac1-Gal4 TimpScer\UAS.cSa Phenotype manifest in Allele adult abdomen Timp28 basement membrane | pupal stage, with Scer\GAL4Lsp2.PH TimpScer\UAS.cSa basement membrane | pupal stage, with Scer\GAL4Ubx-lac1-Gal4 TimpScer\UAS.cSa dendritic arborizing neuron | P-stage, with Scer\GAL4ppk.PG TimpScer\UAS.cPa dorsal air sac, with Scer\GAL4btl.PS TimpScer\UAS.cPa dorsal air sac primordium | ectopic | third instar larval stage, with Scer\GAL4ap-md544 TimpScer\UAS.cPa dorsal air sac primordium | third instar larval stage, with Scer\GAL4btl.PS TimpScer\UAS.cPa dorsal air sac primordium tip cell | third instar larval stage | heat sensitive, with Scer\GAL4btl.PS, Scer\GAL80ts.αTub84B TimpScer\UAS.cPa embryonic/larval dorsal branch | third instar larval stage, with Scer\GAL4btl.PS TimpScer\UAS.cPa embryonic/larval dorsal trunk, with Scer\GAL4btl.PS TimpScer\UAS.cPa embryonic/larval transverse connective | ectopic | third instar larval stage, with Scer\GAL4ap-md544 TimpScer\UAS.cPa embryonic/larval transverse connective | third instar larval stage, with Scer\GAL4btl.PS TimpScer\UAS.cPa leg | pupal stage, with Scer\GAL4Lsp2.PH TimpScer\UAS.cSa mesothoracic tergum | dorsal, with Scer\GAL4Lsp2.PH TimpScer\UAS.cSa tracheal air sac | third instar larval stage | heat sensitive, with Scer\GAL4btl.PS, Scer\GAL80ts.αTub84B TimpScer\UAS.cPa wing Timp28 wing, with Scer\GAL4Lsp2.PH TimpScer\UAS.cSa wing | cold sensitive Timp28 TimpP1+P2 wing | pupal stage, with Scer\GAL4Lsp2.PH TimpScer\UAS.cSa wing | pupal stage, with Scer\GAL4Ubx-lac1-Gal4 TimpScer\UAS.cSa wing disc | third instar larval stage, with Scer\GAL4ap-md544 TimpScer\UAS.cPa wing disc | third instar larval stage, with Scer\GAL4btl.PS TimpScer\UAS.cPa wing vein | cold sensitive Timp28
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Timp Class Mutagen Stocks Known lesion TimpMB01857 1 -- Timp28 loss of function allele P-element activity 0 Yes TimpP1+P2 hypomorphic allele - genetic evidence P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Timp Class Mutagen Stocks Known lesion TimpGD4783 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes TimpKK108268 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes TimpNIG.6281R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes TimpScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes TimpScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6156 (Ryder, 2004.4.26)
Partially disrupted in	Df(3R)Timp-Syn28 (Godenschwege et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4783} NA P{KK108268} NA P{NIG.6281R} NA P{UAS-Timp.P} NA P{UAS-Timp.S} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Syne00238 NA insertion of enhancer trap binary system Mi{ET1}SynMB01857 No insertion of enhancer trap P{lacW}SynP2 No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
metalloendopeptidase inhibitor activity inferred from direct assay (Wei et al., 2003)
Biological Process
CV term Evidence References
basement membrane organization inferred from mutant phenotype (Guha et al., 2009) cell adhesion inferred from mutant phenotype (Godenschwege et al., 2000) delamination inferred from mutant phenotype (Kiger et al., 2007) imaginal disc-derived wing expansion inferred from mutant phenotype (Kiger et al., 2007) phototaxis inferred from mutant phenotype (Godenschwege et al., 2000) tracheal outgrowth, open tracheal system inferred from mutant phenotype (Guha et al., 2009) tracheal pit formation in open tracheal system inferred from mutant phenotype (Guha et al., 2009) wing disc morphogenesis inferred from mutant phenotype (Kiger et al., 2007)
Cellular Component
CV term Evidence References
dendrite inferred from mutant phenotype (Kuo et al., 2005)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
metalloendopeptidase inhibitor activity inferred from sequence or structural similarity (assigned by UniProtKB) (Pohar et al., 1999) non-traceable author statement (Buchner, 1998.8.12)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence or structural similarity (assigned by UniProtKB) (Pohar et al., 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Timp - Aats-arg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Arc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Arf102F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG10688 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG10916 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG14695 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG14749 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG1532 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG16753 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG2010 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG2065 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG2691 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG30344 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG32344 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG33303 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG3523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG4806 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG5190 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG6118 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG6439 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG6724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG6937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG7137 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG8801 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG8888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG8939 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - CG9775 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Cyp6d4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Fer1HCH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - GstE6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Hel25E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Ice anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Ip259 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - LRP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Mi-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Nop56 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Ostγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Pdi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - REG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Rab5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Ras85D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - RnrL anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - RpL24-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - RpL7-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - RpS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - RpS19b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Rs1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - SF1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Sc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Surf6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Tango4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Tcp-1ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Teh1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - ball anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - clu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - eIF3-S8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - eIF6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - levy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - mRpL19 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - mRpL39 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - mRpL52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - ppan anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - robl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - tmod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Timp - vig anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Timp allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66397 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025879 DroID - A comprehensive database of gene and protein interactions. • FBgn0025879 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41248
Orthologs
OrthoDB Orthologs (29) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6CVGT7 Dipteran inclusive ortholog search EOG6V43HX Insect inclusive ortholog search EOG6CZ9C7 Arthropod inclusive ortholog search EOG6905S9 Metazoa inclusive ortholog search EOG65N114
Orthologs in Drosophila Species (EOG6CVGT7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Timp     Drosophila simulans   Dsim\GD20727 Y   Drosophila sechellia   Dsec\GM26178 Y   Drosophila erecta   Dere\GG17294 Y   Drosophila yakuba   Dyak\GE24695 Y   Drosophila ananassae   Dana\GF17533 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19485 Y   Drosophila persimilis   Dper\GL23838 Y   Drosophila willistoni   Dwil\GK22534 Y   Drosophila virilis   Dvir\GJ23665 Y   Drosophila mojavensis   Dmoj\GI24034 Y   Drosophila grimshawi   Dgri\GH18457 Y
Orthologs in non-Drosophila Dipterans (EOG6V43HX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013525   Anopheles gambiae Malaria mosquito  Agam\AGAP003319   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003282
Orthologs in non-Dipteran Insects (EOG6CZ9C7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB40700   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17752   Atta cephalotes Leafcutter ant  Acep\ACEP15631   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13407   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13805   Linepithema humile Argentine ant  Lhum\LH14008   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14560   Solenopsis invicta Red fire ant  Sinv\SINV25818   Tribolium castaneum Red flour beetle  Tcas\TC002305
Orthologs in non-Insect Arthropods (EOG6905S9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW005740
Orthologs in non-Arthropod Metazoa (EOG65N114)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008862gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008865gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008859gn   Danio rerio Zebrafish  Drer\ENSDARG00000090394
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20727 Drosophila sechellia Dsec\GM26178 Drosophila erecta Dere\GG17294 Drosophila yakuba Dyak\GE24695 Drosophila ananassae Dana\GF17533 Drosophila pseudoobscura pseudoobscura Dpse\GA19485 Drosophila persimilis Dper\GL23838 Drosophila willistoni Dwil\GK22534 Drosophila virilis Dvir\GJ23665 Drosophila mojavensis Dmoj\GI24034 Drosophila grimshawi Dgri\GH18457
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	23762 y1 w67c23; Mi{ET1}SynMB01857 TimpMB01857
VDRC	v15372 w1118; P{GD4783}v15372 v15373 w1118; P{GD4783}v15373
Genomic Clones ( 1 )
	BACR28B01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 11 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH26186
Other clones	DPiM_GH26186
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH03751 RH72749
Other clones	Dmel_neb_015048_0578_1800 EK149508 EP01007 ESG012c.E21_D05 ESG016c.E21_A07 ESG0110c.E21.1_A07 RP004243342
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025879 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41248
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Timp mutants suffer from a bloated gut and progressive dissolution of internal tissues and die prematurely. (Godenschwege et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169336 RefSeq (Proteins) • NP_731461 DDBJ / EMBL / GenBank • AAF54507 AAL39356 AAN13465 AI406008 AJ010067 AW941882 AY069211 CAA08989 Entrez Gene - A searchable database of RefSeq genes. • 41248 UniProtKB/Swiss-Prot • Q9VH14 UniProtKB/TrEMBL • A4V2N5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Netrin domain (IPR001134) Proteinase inhibitor I35, tissue inhibitor of metalloproteinase (IPR001820) Tissue inhibitor of metalloproteinases-like, OB-fold (IPR008993) Proteinase inhibitor I35, tissue inhibitor of metalloproteinase, C-terminal domain (IPR027465) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH26186
Linkouts
	BioGRID - A database of protein and genetic interactions • 66397 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0025879 DroID - A comprehensive database of gene and protein interactions. • FBgn0025879 DRSC - Results from RNAi screens. • FBgn0025879 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025879 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6281-RB;CG6281-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025879 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41248 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41248 modMine - Data generated by the modENCODE project. • FBgn0025879
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG6281 (Lee et al., 2003, Kiger et al., 2007, Keleman et al., 2009.8.5, Cammarato et al., 2011) Dtimp (Medioni and Noselli, 2005) dTIMP (Devine and Krasnow, 2003) DTIMP (Pohar et al., 1999) timp (Kobayashi et al., 2004, Kiger et al., 2004, Kao et al., 1999, Buchner, 1998.8.12, ) TIMP (Beaucher et al., 2003, Page-McCaw et al., 2002, Srivastava et al., 2007, Beaucher et al., 2007, Guha et al., 2009, Siekhaus et al., 2010, Chatterjee et al., 2011, Bangi et al., 2012) Timp (Zhang et al., 2006, Godenschwege et al., 2000, Godenschwege et al., 2004, Uhlirova and Bohmann, 2006, Pearson and Gonzalez-Reyes, 2008, Hazelett et al., 2012, Zhai et al., 2012, Kiger et al., 2007, Neisch et al., 2010, Miller et al., 2008, Wang et al., 2010, Glasheen et al., 2009, Cherbas et al., 2011, Jiang et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Stevens and Page-McCaw, 2012, Sui et al., 2012)
Name Synonym	tissue inhibitor of metalloproteases (Buchner, 1998.8.12, ) Tissue inhibitor of metalloproteases (Pearson and Gonzalez-Reyes, 2008, Chatterjee et al., 2011, Cammarato et al., 2011) tissue inhibitor of metalloproteinases (Godenschwege et al., 2000, Stevens and Page-McCaw, 2012)
Secondary FlyBase IDs
References ( 58 )
Generate a list of	All references relating to this gene ( 58 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 7 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 10 )
	Bangi et al., 2012, EMBO Rep. 13(6): 569--576 Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells. [FBrf0218473] Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Stevens and Page-McCaw, 2012, Mol. Biol. Cell 23(6): 1068--1079 A secreted MMP is required for reepithelialization during wound healing. [FBrf0217752] Sui et al., 2012, Development 139(15): 2773--2782 The Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc. [FBrf0218841] Zhai et al., 2012, PLoS Genet. 8(3): e1002582 Antagonistic regulation of apoptosis and differentiation by the cut transcription factor represents a tumor-suppressing mechanism in Drosophila. [FBrf0217859] Bond et al., 2011, Dev. Biol. 360(2): 286--296 ßFTZ-F1 and Matrix metalloproteinase 2 are required for fat-body remodeling in Drosophila. [FBrf0216600] Chatterjee et al., 2011, Development 138(6): 1099--1109 The female-specific Doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. [FBrf0213054] Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Jiang et al., 2011, Oncogene 30(29): 3248--3260 Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. [FBrf0214488] Siller and Broadie, 2011, Dis. Model Mech. 4(5): 673--685 Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase. [FBrf0215041] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...