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Gene Dmel\Eph

General Information
Symbol	Dmel\Eph	Species	D. melanogaster
Name	Eph receptor tyrosine kinase	Annotation symbol	CG1511
Feature type	protein_coding_gene	FlyBase ID	FBgn0025936
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Dek, Deph, CT3831
Genomic Location
Chromosome (arm)	4	Recombination map
Cytogenetic map	102D1-102D1	Sequence location	4:631,312..641,552 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Eph receptor tyrosine kinase is referred to in FlyBase by the symbol Dmel\Eph (CG1511, FBgn0025936). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process: mushroom body development. 17 alleles are reported. The phenotypes of these alleles are annotated with: medulla neuropil; commissure; fascicle; lobula plate cortex; cortex of medulla; longitudinal connective; mushroom body medial lobe; mushroom body vertical lobe; embryonic/larval optic lobe; embryonic/larval neuron. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Ephrin receptor, ligand binding; Fibronectin, type III; Galactose-binding domain-like; Growth factor, receptor; Immunoglobulin-like fold; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Sterile alpha motif domain; Sterile alpha motif, type 1; Sterile alpha motif/pointed domain; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain; Tyrosine-protein kinase, ephrin receptor; Tyrosine-protein kinase, ephrin receptor Dek-like; Tyrosine-protein kinase, receptor class V, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641458_s_at completely aligns to an exonic region common to each of the 6 FlyBase-annotated transcript isoforms of Eph. Gene sequence location is 4:631312..641552.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Unknown in situ Controlled Vocabulary Terms P-stage larval stage ventral nerve cord commissure pharate adult stage P14 imaginal disc pharate adult stage P15(ii) neurogenic region embryonic cycle 3 pharate adult stage P13 pharate adult stage P11 ventral nerve cord pharate adult stage pharate adult stage P15(i) pharate adult stage P12(i) embryonic stage 13 neuron unfertilized egg stage pharate adult stage P15 pharate adult stage P12(ii) pharate adult stage P9 organism embryonic/larval central nervous system pharate adult stage P10 interneuron longitudinal connective pupal stage pharate adult stage P8 embryonic stage adult stage embryonic stage 2 axon axonal growth cone pharate adult stage P12 presumptive embryonic/larval central nervous system embryonic stage 3 embryonic cycle 6 embryonic stage 15 embryonic stage 1 embryonic cycle 5 embryonic cycle 8 egg embryonic cycle 7 pharate adult stage P11(i) axon embryonic cycle 4 embryonic stage 14 embryonic stage 10 embryonic stage 17 pharate adult stage P11(ii) embryonic stage 16
FB2012_01	Sequence features BKN50401 HFA17164 BKN50257 BKN21882
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 102D1-102D1
Experimentally Determined Cytological Location
Cytogenetic map Notes References 102C6-102C6     (Scully, 1999.2.28) 102C-102C     (He, 1999.4.28) 102C6-102C6   (determined by in situ hybridisation)   (Scully et al., 1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Eph for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Eph-RA FBtr0089082  NM_166775   4140   1080 Eph-RB FBtr0089083  NM_166777   4066   1047 Eph-RC FBtr0089084  NM_079886   4188   1096 Eph-RD FBtr0089085  NM_166774   3689   1080 Eph-RE FBtr0089086  NM_166776   3948   1080 Eph-RF FBtr0301285  NM_001169353   3818   1005
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Eph-PA   FBpp0088151   121.5   1080   6.77     NP_726589   AAG22122 Eph-PB   FBpp0088152   117.9   1047   6.61     NP_726591   AAN06504 Eph-PC   FBpp0088153   123.3   1096   6.87     NP_524625   AAF59329 Eph-PD   FBpp0088154   121.7   1080   6.77     NP_726588   AAN06502 Eph-PE   FBpp0088155   121.5   1080   6.77     NP_726590   AAN06503 Eph-PF   FBpp0290500   112.9   1005   6.30     NP_001162824   ACZ95093
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Ephrin receptor, ligand binding (IPR001090) Sterile alpha motif domain (IPR001660) Fibronectin, type III (IPR003961) Tyrosine-protein kinase, active site (IPR008266) Galactose-binding domain-like (IPR008979) Protein kinase-like domain (IPR011009) Tyrosine-protein kinase, receptor class V, conserved site (IPR001426) Tyrosine-protein kinase, ephrin receptor (IPR016257) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, ephrin receptor Dek-like (IPR020694) Tyrosine-protein kinase, catalytic domain (IPR020635) Sterile alpha motif, type 1 (IPR021129) Serine-threonine/tyrosine-protein kinase (IPR001245) Growth factor, receptor (IPR009030) Immunoglobulin-like fold (IPR013783) Sterile alpha motif/pointed domain (IPR013761)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202579   AA438323   AA439824   AA538926   AA540090   AA540177   AA698678   AA820775   AE014135 AAF59329   AE014135 AAG22122   AE014135 AAN06502   AE014135 AAN06503   AE014135 AAN06504   AE014135 ACZ95093   AF052730 AAC99308   AF132028 AAD38508   AF146648 AAD30170   AY118403 AAM48432   BG637757   BG638069   BI213604   BI216114   BI236295   BI243044   BI356092   BI357885   BI357892   BI362512   BI372165   BI373680   BI484831   BI580741   BP545383   BP545384   BT021297 AAX33445   BT125744   BT126060   CO177231   CO177607   CO185604   CO186486   CO188889   CO189144   CO189721   CO189919   CO190266   CO190708   CO262242   CO262852   CO263163   CO263170   CO263462   CO264365   CO265797   CO268204   CO268225   CO269802   CO269853   CO273133   CO273693   CO273788   CO274939   CO275064   CO275199   CO275873   CO276262   CO276561   CO283384   CO284254   CO284406   CO285889   CO286043   CO286227   CO287884   CO289463   CO290394   CO293755   CO293966   CO294295   CO294379   CO295780   CO298728   CO302947   CO303588   CO304213   CO304323   CO305704   CO306213   CO307129   CO312053   CO313826   CO316848   CO317072   CO317153   CO318718   CO320766   CO322010   CO324359   CO328548   CO329621   CO330538   CO330963   CO331582   CO331740   CO332636   CO333880   CO340543   CO341690   CO342781   CO344086   EC051029   EC052537   EC057131   EC057132   EC057563   EC058442   EC058613   EC060588   EC065313   EC065976   EC070360   EC070723   EC071485   EC071487   EC076433   EC077127   EC078067   EC078972   EC079026   EC079405   EC080735   EC082097   EC082205   EC083419   EC084334   EC088114   EC088703   EC090207   EC090508   EC195962   EC196592   EC196808   EC196817   EC198086   EC199515   EC201553   EC202580   EC203355   EC203457   EC204035   EC204385   EC205149   EC208949   EC208964   EC211756   EC215544   EC220179   EC221277   EC221884   EC226826   EC227699   EC228071   EC229895   EC230432   EC231311   EC232664   EC234840   EC238589   EC239266   EC240428   EC240708   EC241230   EC241269   EC242655   EC243228   EC243346   EC243513   EC244571   EC246725   EC247321   EC248652   EC251146   EC254875   EC255056   EV578311   EV599771   EV599988   GH943924   GH949336   GH953215   GH955510   GH959782   GH959814   GH967825   GH968253   GH973617   GH974179   GH975236   GH976823   GH980278   GH982398   GH984806   GH984946
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O96435 Q59DQ4 Q5BIC7 Q8IMC2 Q8MT37 Q9V4E5 Q9XZL6 Q9Y1J0 Q0KIF4 D1YSF9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Scully et al., 1999) Comment:higher concentration at posterior pole embryonic stage 10   neurogenic region   (Scully et al., 1999) embryonic stage 13 -- 17   presumptive embryonic/larval central nervous system   (Scully et al., 1999) embryonic stage 16   neuron of ventral nerve cord   (Scully et al., 1999) unfertilized egg stage   egg   (Scully et al., 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference larval stage   embryonic/larval central nervous system   (Scully et al., 1999) imaginal disc   (Scully et al., 1999) pupal stage -- adult stage   organism   (Scully et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   neuron of ventral nerve cord   • axon (Scully et al., 1999) neuron of ventral nerve cord   • axonal growth cone (Scully et al., 1999) embryonic stage 16   longitudinal connective   (Scully et al., 1999) interneuron of ventral nerve cord   (Scully et al., 1999) ventral nerve cord commissure   • axon (Scully et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0025936    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0025936 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0025936 expression level Developmental Stage   Expression Level embryo 00-02hr    2078 embryo 02-04hr    2485 embryo 04-06hr    4402 embryo 06-08hr    3605 embryo 08-10hr    3991 embryo 10-12hr    2028 embryo 12-14hr    4148 embryo 14-16hr    1147 embryo 16-18hr    1730 embryo 18-20hr    883 embryo 20-22hr    868 embryo 22-24hr    1579 larva L1    724 larva L2    690 larva L3 12hr old    537 larva L3 puffstage 1-2    657 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9    2313 white prepupae new    2815 white prepupae 12hr    2223 white prepupae 24hr    2616 pupae 2d postWPP    2297 pupae 3d postWPP    1263 pupae 4d postWPP    443 adult male 01day    885 adult male 05day    702 adult male 30day    562 adult female 01day    570 adult female 05day    1648 adult female 30day    1200 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2078) embryo 02-04hr  (2485) embryo 04-06hr  (4402) embryo 06-08hr  (3605) embryo 08-10hr  (3991) embryo 10-12hr  (2028) embryo 12-14hr  (4148) embryo 14-16hr  (1147) embryo 16-18hr  (1730) embryo 18-20hr  (883) embryo 20-22hr  (868) embryo 22-24hr  (1579) larva L1  (724) larva L2  (690) larva L3 12hr old  (537) larva L3 puffstage 1-2  (657) larva L3 puffstage 3-6  (1201) larva L3 puffstage 7-9  (2313) white prepupae new  (2815) white prepupae 12hr  (2223) white prepupae 24hr  (2616) pupae 2d postWPP  (2297) pupae 3d postWPP  (1263) pupae 4d postWPP  (443) adult male 01day  (885) adult male 05day  (702) adult male 30day  (562) adult female 01day  (570) adult female 05day  (1648) adult female 30day  (1200) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2078) embryo 02-04hr  (2485) embryo 04-06hr  (4402) embryo 06-08hr  (3605) embryo 08-10hr  (3991) embryo 10-12hr  (2028) embryo 12-14hr  (4148) embryo 14-16hr    1147 embryo 16-18hr  (1730) embryo 18-20hr    883 embryo 20-22hr    868 embryo 22-24hr  (1579) larva L1    724 larva L2    690 larva L3 12hr old    537 larva L3 puffstage 1-2    657 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9  (2313) white prepupae new  (2815) white prepupae 12hr  (2223) white prepupae 24hr  (2616) pupae 2d postWPP  (2297) pupae 3d postWPP    1263 pupae 4d postWPP    443 adult male 01day    885 adult male 05day    702 adult male 30day    562 adult female 01day    570 adult female 05day  (1648) adult female 30day    1200 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2078 embryo 02-04hr    2485 embryo 04-06hr    4402 embryo 06-08hr    3605 embryo 08-10hr    3991 embryo 10-12hr    2028 embryo 12-14hr    4148 embryo 14-16hr    1147 embryo 16-18hr    1730 embryo 18-20hr    883 embryo 20-22hr    868 embryo 22-24hr    1579 larva L1    724 larva L2    690 larva L3 12hr old    537 larva L3 puffstage 1-2    657 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9    2313 white prepupae new    2815 white prepupae 12hr    2223 white prepupae 24hr    2616 pupae 2d postWPP    2297 pupae 3d postWPP    1263 pupae 4d postWPP    443 adult male 01day    885 adult male 05day    702 adult male 30day    562 adult female 01day    570 adult female 05day    1648 adult female 30day    1200 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2078 embryo 02-04hr    2485 embryo 04-06hr    4402 embryo 06-08hr    3605 embryo 08-10hr    3991 embryo 10-12hr    2028 embryo 12-14hr    4148 embryo 14-16hr    1147 embryo 16-18hr    1730 embryo 18-20hr    883 embryo 20-22hr    868 embryo 22-24hr    1579 larva L1    724 larva L2    690 larva L3 12hr old    537 larva L3 puffstage 1-2    657 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9    2313 white prepupae new    2815 white prepupae 12hr    2223 white prepupae 24hr    2616 pupae 2d postWPP    2297 pupae 3d postWPP    1263 pupae 4d postWPP    443 adult male 01day    885 adult male 05day    702 adult male 30day    562 adult female 01day    570 adult female 05day    1648 adult female 30day    1200 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0025936 expression level Developmental Stage   Expression Level embryo 00-02hr    2078 embryo 02-04hr    2485 embryo 04-06hr    4402 embryo 06-08hr    3605 embryo 08-10hr    3991 embryo 10-12hr    2028 embryo 12-14hr    4148 embryo 14-16hr    1147 embryo 16-18hr    1730 embryo 18-20hr    883 embryo 20-22hr    868 embryo 22-24hr    1579 larva L1    724 larva L2    690 larva L3 12hr old    537 larva L3 puffstage 1-2    657 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9    2313 white prepupae new    2815 white prepupae 12hr    2223 white prepupae 24hr    2616 pupae 2d postWPP    2297 pupae 3d postWPP    1263 pupae 4d postWPP    443 adult male 01day    885 adult male 05day    702 adult male 30day    562 adult female 01day    570 adult female 05day    1648 adult female 30day    1200 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2078) embryo 02-04hr  (2485) embryo 04-06hr  (4402) embryo 06-08hr  (3605) embryo 08-10hr  (3991) embryo 10-12hr  (2028) embryo 12-14hr  (4148) embryo 14-16hr  (1147) embryo 16-18hr  (1730) embryo 18-20hr  (883) embryo 20-22hr  (868) embryo 22-24hr  (1579) larva L1  (724) larva L2  (690) larva L3 12hr old  (537) larva L3 puffstage 1-2  (657) larva L3 puffstage 3-6  (1201) larva L3 puffstage 7-9  (2313) white prepupae new  (2815) white prepupae 12hr  (2223) white prepupae 24hr  (2616) pupae 2d postWPP  (2297) pupae 3d postWPP  (1263) pupae 4d postWPP  (443) adult male 01day  (885) adult male 05day  (702) adult male 30day  (562) adult female 01day  (570) adult female 05day  (1648) adult female 30day  (1200) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2078 embryo 02-04hr  (2485) embryo 04-06hr  (4402) embryo 06-08hr  (3605) embryo 08-10hr  (3991) embryo 10-12hr  2028 embryo 12-14hr  (4148) embryo 14-16hr    1147 embryo 16-18hr  1730 embryo 18-20hr    883 embryo 20-22hr    868 embryo 22-24hr  1579 larva L1    724 larva L2    690 larva L3 12hr old    537 larva L3 puffstage 1-2    657 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9  2313 white prepupae new  (2815) white prepupae 12hr  2223 white prepupae 24hr  (2616) pupae 2d postWPP  2297 pupae 3d postWPP    1263 pupae 4d postWPP    443 adult male 01day    885 adult male 05day    702 adult male 30day    562 adult female 01day    570 adult female 05day  1648 adult female 30day    1200 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2078 embryo 02-04hr    2485 embryo 04-06hr    4402 embryo 06-08hr    3605 embryo 08-10hr    3991 embryo 10-12hr    2028 embryo 12-14hr    4148 embryo 14-16hr    1147 embryo 16-18hr    1730 embryo 18-20hr    883 embryo 20-22hr    868 embryo 22-24hr    1579 larva L1    724 larva L2    690 larva L3 12hr old    537 larva L3 puffstage 1-2    657 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9    2313 white prepupae new    2815 white prepupae 12hr    2223 white prepupae 24hr    2616 pupae 2d postWPP    2297 pupae 3d postWPP    1263 pupae 4d postWPP    443 adult male 01day    885 adult male 05day    702 adult male 30day    562 adult female 01day    570 adult female 05day    1648 adult female 30day    1200 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2078 embryo 02-04hr    2485 embryo 04-06hr    4402 embryo 06-08hr    3605 embryo 08-10hr    3991 embryo 10-12hr    2028 embryo 12-14hr    4148 embryo 14-16hr    1147 embryo 16-18hr    1730 embryo 18-20hr    883 embryo 20-22hr    868 embryo 22-24hr    1579 larva L1    724 larva L2    690 larva L3 12hr old    537 larva L3 puffstage 1-2    657 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9    2313 white prepupae new    2815 white prepupae 12hr    2223 white prepupae 24hr    2616 pupae 2d postWPP    2297 pupae 3d postWPP    1263 pupae 4d postWPP    443 adult male 01day    885 adult male 05day    702 adult male 30day    562 adult female 01day    570 adult female 05day    1648 adult female 30day    1200 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0025936    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0025936 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0025936 expression level Tissue   Expression Level Larval Central Nervous System    351.8 Larval Midgut    100.3 Larval Hindgut    126.5 Larval Malpighian Tubules    132.6 Larval Fat Body    151 Larval Salivary Gland    138 Larval Trachea    132.65 Larval Carcass    131.55 Adult Head    201.7 Adult Eye    176.325 Adult Brain    433.8 Adult Thoracic-Abdominal Ganglion    307.5 Adult Crop    235.4 Adult Midgut    107.4 Adult Hindgut    135.2 Adult Malpighian Tubules    116.5 Adult Fat Body    101.3 Adult Salivary Gland    237.3 Adult Heart    127.875 Adult VirginFemale Spermatheca    74.6 Adult InseminatedFemale Spermatheca    88.6 Adult Ovary    329.4 Adult Testis    88 Adult Male Accessory Gland    343.1 Adult Carcass    134.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    351.8 Larval Midgut    100.3 Larval Hindgut    126.5 Larval Malpighian Tubules    132.6 Larval Fat Body    151 Larval Salivary Gland    138 Larval Trachea    132.65 Larval Carcass    131.55 Adult Head    201.7 Adult Eye    176.325 Adult Brain    433.8 Adult Thoracic-Abdominal Ganglion    307.5 Adult Crop    235.4 Adult Midgut    107.4 Adult Hindgut    135.2 Adult Malpighian Tubules    116.5 Adult Fat Body    101.3 Adult Salivary Gland    237.3 Adult Heart    127.875 Adult VirginFemale Spermatheca    74.6 Adult InseminatedFemale Spermatheca    88.6 Adult Ovary    329.4 Adult Testis    88 Adult Male Accessory Gland    343.1 Adult Carcass    134.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    351.8 Larval Midgut    100.3 Larval Hindgut    126.5 Larval Malpighian Tubules    132.6 Larval Fat Body    151 Larval Salivary Gland    138 Larval Trachea    132.65 Larval Carcass    131.55 Adult Head    201.7 Adult Eye    176.325 Adult Brain    433.8 Adult Thoracic-Abdominal Ganglion    307.5 Adult Crop    235.4 Adult Midgut    107.4 Adult Hindgut    135.2 Adult Malpighian Tubules    116.5 Adult Fat Body    101.3 Adult Salivary Gland    237.3 Adult Heart    127.875 Adult VirginFemale Spermatheca    74.6 Adult InseminatedFemale Spermatheca    88.6 Adult Ovary    329.4 Adult Testis    88 Adult Male Accessory Gland    343.1 Adult Carcass    134.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    351.8 Larval Midgut    100.3 Larval Hindgut    126.5 Larval Malpighian Tubules    132.6 Larval Fat Body    151 Larval Salivary Gland    138 Larval Trachea    132.65 Larval Carcass    131.55 Adult Head    201.7 Adult Eye    176.325 Adult Brain    433.8 Adult Thoracic-Abdominal Ganglion    307.5 Adult Crop    235.4 Adult Midgut    107.4 Adult Hindgut    135.2 Adult Malpighian Tubules    116.5 Adult Fat Body    101.3 Adult Salivary Gland    237.3 Adult Heart    127.875 Adult VirginFemale Spermatheca    74.6 Adult InseminatedFemale Spermatheca    88.6 Adult Ovary    329.4 Adult Testis    88 Adult Male Accessory Gland    343.1 Adult Carcass    134.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0025936 expression level Tissue   Expression Level Larval Central Nervous System    351.8 Larval Midgut    100.3 Larval Hindgut    126.5 Larval Malpighian Tubules    132.6 Larval Fat Body    151 Larval Salivary Gland    138 Larval Trachea    132.65 Larval Carcass    131.55 Adult Head    201.7 Adult Eye    176.325 Adult Brain    433.8 Adult Thoracic-Abdominal Ganglion    307.5 Adult Crop    235.4 Adult Midgut    107.4 Adult Hindgut    135.2 Adult Malpighian Tubules    116.5 Adult Fat Body    101.3 Adult Salivary Gland    237.3 Adult Heart    127.875 Adult VirginFemale Spermatheca    74.6 Adult InseminatedFemale Spermatheca    88.6 Adult Ovary    329.4 Adult Testis    88 Adult Male Accessory Gland    343.1 Adult Carcass    134.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    351.8 Larval Midgut    100.3 Larval Hindgut    126.5 Larval Malpighian Tubules    132.6 Larval Fat Body    151 Larval Salivary Gland    138 Larval Trachea    132.65 Larval Carcass    131.55 Adult Head    201.7 Adult Eye    176.325 Adult Brain    433.8 Adult Thoracic-Abdominal Ganglion    307.5 Adult Crop    235.4 Adult Midgut    107.4 Adult Hindgut    135.2 Adult Malpighian Tubules    116.5 Adult Fat Body    101.3 Adult Salivary Gland    237.3 Adult Heart    127.875 Adult VirginFemale Spermatheca    74.6 Adult InseminatedFemale Spermatheca    88.6 Adult Ovary    329.4 Adult Testis    88 Adult Male Accessory Gland    343.1 Adult Carcass    134.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    351.8 Larval Midgut    100.3 Larval Hindgut    126.5 Larval Malpighian Tubules    132.6 Larval Fat Body    151 Larval Salivary Gland    138 Larval Trachea    132.65 Larval Carcass    131.55 Adult Head    201.7 Adult Eye    176.325 Adult Brain    433.8 Adult Thoracic-Abdominal Ganglion    307.5 Adult Crop    235.4 Adult Midgut    107.4 Adult Hindgut    135.2 Adult Malpighian Tubules    116.5 Adult Fat Body    101.3 Adult Salivary Gland    237.3 Adult Heart    127.875 Adult VirginFemale Spermatheca    74.6 Adult InseminatedFemale Spermatheca    88.6 Adult Ovary    329.4 Adult Testis    88 Adult Male Accessory Gland    343.1 Adult Carcass    134.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    351.8 Larval Midgut    100.3 Larval Hindgut    126.5 Larval Malpighian Tubules    132.6 Larval Fat Body    151 Larval Salivary Gland    138 Larval Trachea    132.65 Larval Carcass    131.55 Adult Head    201.7 Adult Eye    176.325 Adult Brain    433.8 Adult Thoracic-Abdominal Ganglion    307.5 Adult Crop    235.4 Adult Midgut    107.4 Adult Hindgut    135.2 Adult Malpighian Tubules    116.5 Adult Fat Body    101.3 Adult Salivary Gland    237.3 Adult Heart    127.875 Adult VirginFemale Spermatheca    74.6 Adult InseminatedFemale Spermatheca    88.6 Adult Ovary    329.4 Adult Testis    88 Adult Male Accessory Gland    343.1 Adult Carcass    134.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    201.7   NA  Eye    176.325   NA  Brain    433.8   351.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    307.5   NA  Crop    235.4   100.3  Midgut    107.4   126.5  Hindgut    135.2   132.6  Malpighian Tubules    116.5   151  Fat Body    101.3   138  Salivary Gland    237.3   NA  Heart    127.875   132.65  Trachea    NA   NA  VirginFemale Spermatheca    74.6   NA  InseminatedFemale Spermatheca    88.6   NA  Ovary    329.4   NA  Testis    88   NA  Male Accessory Gland    343.1   131.55  Carcass    134.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025936 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1511-RD
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 EphGD39 viable, with Scer\GAL4A80 EphK579M.Scer\UAS.T:Hsap\MYC EphScer\UAS.T:Hsap\MYC viable, with Scer\GAL4elav.PLu EphK579M.Scer\UAS.T:Hsap\MYC EphScer\UAS.cSa EphScer\UAS.T:Hsap\MYC viable, with Scer\GAL4elav.PLu, Scer\GAL4sca-537.4 EphK579M.Scer\UAS.T:Hsap\MYC EphScer\UAS.T:Hsap\MYC viable, with Scer\GAL4elav-C155 EphK579M.Scer\UAS.T:Hsap\MYC EphScer\UAS.T:Hsap\MYC viable, with Scer\GAL4ftz.ng EphK579M.Scer\UAS.T:Hsap\MYC EphScer\UAS.cSa EphScer\UAS.T:Hsap\MYC viable, with Scer\GAL4GMR.PF EphK579M.Scer\UAS.T:Hsap\MYC EphScer\UAS.cSa EphScer\UAS.T:Hsap\MYC viable, with Scer\GAL4pnr-MD237 EphGD2535 EphGD14481 viable, with Scer\GAL4sca-537.4 EphK579M.Scer\UAS.T:Hsap\MYC EphScer\UAS.cSa EphScer\UAS.T:Hsap\MYC viable | recessive Ephx652 Sterility Allele fertile | recessive Ephx652 Other Phenotypes Allele neuroanatomy defective EphdsRNA.cBa EphdsRNA.cDa Ephx652 neuroanatomy defective, with Scer\GAL4ap-md544 EphDN.Scer\UAS EphScer\UAS.cDa neuroanatomy defective, with Scer\GAL4bi-md653 EphScer\UAS.cDa neuroanatomy defective, with Scer\GAL4ey.PH EphDN.Scer\UAS neuroanatomy defective, with Scer\GAL4αTub84B.PP EphDN.Scer\UAS visible, with Scer\GAL4ap-md544 EphDN.Scer\UAS Phenotype manifest in Allele commissure EphdsRNA.cBa cortex of medulla EphdsRNA.cDa cortex of medulla, with Scer\GAL4ap-md544 EphDN.Scer\UAS EphScer\UAS.cDa cortex of medulla, with Scer\GAL4bi-md653 EphScer\UAS.cDa cortex of medulla, with Scer\GAL4ey.PH EphDN.Scer\UAS cortex of medulla | somatic clone, with Scer\GAL4αTub84B.PP EphDN.Scer\UAS embryonic/larval neuron EphdsRNA.cBa embryonic/larval optic lobe, with Scer\GAL4ey.PH EphDN.Scer\UAS fascicle, with Scer\GAL4elav.PLu, Scer\GAL4sca-537.4 EphScer\UAS.cSa lobula plate cortex EphdsRNA.cDa lobula plate cortex, with Scer\GAL4ey.PH EphDN.Scer\UAS longitudinal connective EphdsRNA.cBa medulla neuropil, with Scer\GAL4bi-md653 EphScer\UAS.cDa medulla neuropil, with Scer\GAL4ey.PH EphDN.Scer\UAS mushroom body medial lobe Ephx652 mushroom body vertical lobe Ephx652 mushroom body vertical lobe | somatic clone Ephx652 photoreceptor & axon EphdsRNA.cDa photoreceptor cell & axon, with Scer\GAL4bi-md653 EphScer\UAS.cDa photoreceptor cell & axon, with Scer\GAL4ey.PH EphDN.Scer\UAS photoreceptor cell R7 & axon | somatic clone, with Scer\GAL4αTub84B.PP EphDN.Scer\UAS photoreceptor cell R8 & axon | somatic clone, with Scer\GAL4αTub84B.PP EphDN.Scer\UAS
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Eph Class Mutagen Stocks Known lesion Eph1520 spontaneous 0 Yes Ephx652 loss of function allele Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Eph Class Mutagen Stocks Known lesion EphGD14481 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes EphGD2535 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes EphGD39 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes EphGL00192 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes EphJF03131 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes EphDN.Scer\UAS in vitro construct - deletion 0 Yes EphdsRNA.cBa in vitro construct - RNAi 0 Yes EphdsRNA.cDa in vitro construct - RNAi 0 Yes EphdsRNA.XbaI in vitro construct - RNAi in vitro construct - deletion 0 Yes Ephex.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes EphK579M.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes EphKK101831 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes EphScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes EphScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes EphScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(4)Ephx652 (Boyle et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD39} NA P{GD2535} NA P{GD14481} NA P{KK101831} NA P{TRiP.GL00192} NA P{TRiP.JF03131} NA P{UAS-eph.D} NA P{UAS-eph.DN} NA P{UAS-Eph.K759M.myc} NA P{UAS-Eph.myc} NA P{UAS-Eph.S} NA reporter construct P{EphC-τ-lacZ} No
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{hsp26-pt-T}P114 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mushroom body development inferred from mutant phenotype (Boyle et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001090, InterPro:IPR001426, InterPro:IPR016257, InterPro:IPR017441 (FlyBase Curators et al., 2004-) ephrin receptor activity inferred from sequence or structural similarity with mouse Ephb2 (FlyBase, 1992-) protein tyrosine kinase activity non-traceable author statement (Shibata, 1998.3.6, Morrison et al., 2000) transmembrane receptor protein tyrosine kinase activity inferred from sequence or structural similarity (Scully et al., 1996, Scully et al., 1997, He and Kunes, 1998, Shibata and Bryant, 1998, Scully et al., 1999) inferred from sequence or structural similarity with mouse Ephb2 (FlyBase, 1992-) non-traceable author statement (Scully, 1999.2.28)
Biological Process
CV term Evidence References
axonogenesis non-traceable author statement (Stoker, 2002) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR001426, InterPro:IPR008266, InterPro:IPR016257, InterPro:IPR020635 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Scully et al., 1999) non-traceable author statement (Morrison et al., 2000) signal transduction inferred from sequence or structural similarity (Scully et al., 1999) transmembrane receptor protein tyrosine kinase signaling pathway inferred from electronic annotation with InterPro:IPR001426, InterPro:IPR016257 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to plasma membrane inferred from electronic annotation with InterPro:IPR016257 (FlyBase Curators et al., 2004-) plasma membrane inferred from sequence or structural similarity (Scully et al., 1997, He and Kunes, 1998, Scully et al., 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Eph allele Gene References EphDN.Scer\UAS Ephrin (Dearborn et al., 2002) EphdsRNA.cBa Ephrin (Bossing and Brand, 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68635 DroID - A comprehensive database of gene and protein interactions. • FBgn0025936 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43803
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22840 Dere\GG16395 Dgri\GH23930 Dmoj\GI14095 Dper\GL18177 Dpse\GA22544 Dsim\GD24409 Dvir\GJ14241 Dwil\GK13696 Dyak\GE14555
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008301-PA Aedes aegypti (mosquito) AGAP000489-PA Anopheles gambiae (mosquito) NP_001013024.1 Apis mellifera (honey bee) At5g49760.1 Arabidopsis thaliana (wall cress) 128499 Branchiostoma floridae (lancelet) BGIBMGA002079-PA Bombyx mori (silk worm) ENSBTAP00000026780 Bos taurus (bovine) CN01693 Caenorhabditis brenneri (small nematode) CN02565 Caenorhabditis brenneri (small nematode) CBP03296 Caenorhabditis briggsae (nematode) CE28617 Caenorhabditis elegans (worm) ENSCAFP00000005078 Canis familiaris (dog) ENSCINP00000025213 Ciona intestinalis (sea squirt) JA15812 Caenorhabditis japonica (nematode) CPIJ014812 Culex pipens (mosquito) ENSCPOP00000003251 Cavia porcellus (guinea pig) RP36012 Caenorhabditis remanei (nematode) ENSCSAVP00000019951 Ciona savignyi (sedentary tunicate) 198909 Capitella spl (polychaete worm) 104369 Daphnia pulex (daphnia) ENSDARP00000043755 Danio rerio (zebra fish) ENSECAP00000019703 Equus caballus (horse) XP_651735 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000018485 Gymnopilus aculeatus (mushroom) ENSGALP00000010654 Gallus gallus (chicken) 119140 Hypsipyla robusta (cedar shoot borer) ENSP00000381097 Homo sapiens (human) ISCW022934-PA Ixodes scapularis (deer tick) 105485 Lottia gigantea (owl limpet) 29610 Monocosta brevicollis (choanoflagellate) ENSMODP00000023092 Monodelphis domestica (gray opossum) ENSMMUP00000028101 Macaca mulatta (rhesus monkey) ENSMUSP00000035129 Mus musculus (house mouse) 10376 Nematostella vectensis (starlet anemone) XP_001606593.1 Nasonia vitripennis (wasp) ENSOANP00000006279 Ornithorynchus anatinus (platypus) ENSORLP00000019993 Oryzias latipes (japanese killifish) LOC_Os01g12420.1 Oryza sativa (asian rice) PHUM003405-PA Pediculus humanus (human body louse) ENSPPYP00000015802 Pongo pygmaeus (orangutan) 568350 Populus trichocarpa (black cottonwood) ENSPTRP00000056656 Pan troglodytes (chimpanzee) ENSRNOP00000010634 Rattus norvegicus (norway rat) 5058774 Sorghum bicolor (sorghum) Smp_139480 Schistosoma mansoni (trematode parasite) XP_001196893.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001199846.1 Strongylocentrotus purpuratus (purple sea urchin) XP_966603.2 Tribolium castaneum (red flour beetle) ENSTNIP00000009289 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000017418 Takifugu rubripes (pufferfish Takifugu) 3717.m00027 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000016595 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11238 LH22870 ISCW022934 FBgn0232154 FBgn0215704 FBgn0201456 FBgn0195747 FBgn0181656 FBgn0181655 JGI_V11_104369 FBgn0243947 FBgn0155780 FBgn0136849 FBgn0131387 FBgn0108627 FBgn0099834 CPIJ014812 BGIBMGA002079 GB12585 AGAP000489 AAEL017107 AAEL010711 AAEL008301 PB23865 PHUM576020 GLEAN_06032
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	28511 y1 v1; P{TRiP.JF03131}attP2 35290 y1 sc* v1; P{TRiP.GL00192}attP2
VDRC	v6545 w1118 P{GD39}v6545 v4771 w1118; P{GD2535}v4771 v27236 w1118; P{GD14481}v27236
Genomic Clones ( 2 )
	BACR06K04 BACR44L03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 185 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE23033 RE61046
Other clones	RT10225 RT11149
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL05461 LD12272 LD18592 LD19448 LD19573 LD24655 RE19039 RE32335 RE40581 RE42135 RE44493 RE44509 RE47088 RE59054 RE67989 RE74967
Other clones	11403 11800 12468 14213 19424 30261 33249 34933 43455 60277 60577 65954 76465 78106 104411 105777 107319 107901 108616 121969 125577 144790 146439 146547 160624 161723 162918 162969 165355 172864 183301 183310 190715 192860 193747 214539.3 272998 273193 273385 276981 282275 CK01.7B.E8 CK01.19A.E1 CK01.21D.F5 CK01.32D.C4 CK01.52B.E7 CK01.52D.E12 CK01.55B.G2 CK01.58C.A10 CK01.78C.C5 CK01.79A.D10 CK01.80B.C12 CK01.84C.C4 CK01.94D.E8 CK01.100B.C5 CK01.104B.G7 CK01.104C.D4 CK01.104C.H4 CK01.106D.G5 CK01.129C.F2 CK01.129D.F5 CK01.143B.C2 CK01.144B.H3 CK01.144C.F9 CK01.147A.G6 CK01.147D.F4 CK01.170C.H10 Dmel_dig_008646_0621_2327 Dmel_neb_011459_0877_1750 Dmel_neb_014528_0871_1961 EC051029 EC052537 EC254875 EK010452 EK020218 EK042320 EK043152 EK044957 EK045602 EK047633 EK049317 EK052947 EK053909 EK061111 EK061545 EK062144 EK067032 EK071107 EK073852 EK084809 EK086530 EK087646 EK087662 EK088604 EK090601 EK090641 EK095953 EK096123 EK109805 EK111928 EK112156 EK116007 EK116341 EK116720 EK119023 EK120159 EK121354 EK138760 EK143651 EK163015 EK165611 EK166003 EK173704 EK185225 EK187006 EK193341 EK204509 EK205244 EK206516 EK206803 EK211556 EK227764 EK234148 EK242156 EK244122 EK244343 EK249258 EK250532 EK253703 EK266037 EK267039 EK267224 EK273525 EK288025 EK290846 EK293250 EK295520 EK296728 EK300562 EK301604 EK304120 EK308237 EP10847 EP12954 EP15510 EP18640 FGC031A04 LD02720 LD14495 RP004042542 RP004095660 RP004133516 RP004186544 RP004221769 RP004242646 RP004244342 RP004309593 RP004347829 RP004368085 RP004378501 RP004457252 RP004462874 RP004472253 RP004552234 RP004552732
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0025936 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43803
Antibody Information
	polyclonal (Scully et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Eph CG1511 (Zhong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Eph/Ephrin signalling acts to guide a subset of mushroom body branches to their correct synaptic targets. (Boyle et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Identification: PCR screen using degenerate primers to conserved regions within the kinase domain of RTKs. (Scully et al., 1997) Identification: recovered from a PCR-based screen for receptor tyrosine kinase encoding genes. (Scully et al., 1996) Dek7 is given as a temporary designation. (Scully, 1996.4.28)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079886 NM_166774 NM_166775 NM_166776 NM_166777 NM_001169353 RefSeq (Proteins) • NP_524625 NP_726588 NP_726589 NP_726590 NP_726591 NP_001162824 DDBJ / EMBL / GenBank • AAC99308 AAD30170 AAD38508 AAF59329 AAF59329.3 AAG22122 AAG22122.2 AAM48432 AAN06502 AAN06502.1 AAN06503 AAN06503.1 AAN06504 AAN06504.1 AAX33445 ACZ95093 AF052730 AF132028 AF146648 AY118403 BI216114 BI373680 BT021297 Entrez Gene - A searchable database of RefSeq genes. • 43803 UniProtKB/TrEMBL • D1YSF9 O96435 Q0KIF4 Q5BIC7 Q8IMC2 Q8MT37 Q9V4E5 Q9XZL6 Q9Y1J0 Q59DQ4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Ephrin receptor, ligand binding (IPR001090) Sterile alpha motif domain (IPR001660) Fibronectin, type III (IPR003961) Tyrosine-protein kinase, active site (IPR008266) Galactose-binding domain-like (IPR008979) Protein kinase-like domain (IPR011009) Tyrosine-protein kinase, receptor class V, conserved site (IPR001426) Tyrosine-protein kinase, ephrin receptor (IPR016257) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, ephrin receptor Dek-like (IPR020694) Tyrosine-protein kinase, catalytic domain (IPR020635) Sterile alpha motif, type 1 (IPR021129) Serine-threonine/tyrosine-protein kinase (IPR001245) Growth factor, receptor (IPR009030) Immunoglobulin-like fold (IPR013783) Sterile alpha motif/pointed domain (IPR013761)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68635 DroID - A comprehensive database of gene and protein interactions. • FBgn0025936 DRSC - Results from RNAi screens. • FBgn0025936 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0025936 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1511-RD FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0025936 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43803 InParanoid A subset of ortholog calls from InParanoid. • AAEL008301-PA Aedes aegypti (mosquito) AGAP000489-PA Anopheles gambiae (mosquito) NP_001013024.1 Apis mellifera (honey bee) At5g49760.1 Arabidopsis thaliana (wall cress) 128499 Branchiostoma floridae (lancelet) BGIBMGA002079-PA Bombyx mori (silk worm) ENSBTAP00000026780 Bos taurus (bovine) CN01693 Caenorhabditis brenneri (small nematode) CN02565 Caenorhabditis brenneri (small nematode) CBP03296 Caenorhabditis briggsae (nematode) CE28617 Caenorhabditis elegans (worm) ENSCAFP00000005078 Canis familiaris (dog) ENSCINP00000025213 Ciona intestinalis (sea squirt) JA15812 Caenorhabditis japonica (nematode) CPIJ014812 Culex pipens (mosquito) ENSCPOP00000003251 Cavia porcellus (guinea pig) RP36012 Caenorhabditis remanei (nematode) ENSCSAVP00000019951 Ciona savignyi (sedentary tunicate) 198909 Capitella spl (polychaete worm) 104369 Daphnia pulex (daphnia) ENSDARP00000043755 Danio rerio (zebra fish) ENSECAP00000019703 Equus caballus (horse) XP_651735 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000018485 Gymnopilus aculeatus (mushroom) ENSGALP00000010654 Gallus gallus (chicken) 119140 Hypsipyla robusta (cedar shoot borer) ENSP00000381097 Homo sapiens (human) ISCW022934-PA Ixodes scapularis (deer tick) 105485 Lottia gigantea (owl limpet) 29610 Monocosta brevicollis (choanoflagellate) ENSMODP00000023092 Monodelphis domestica (gray opossum) ENSMMUP00000028101 Macaca mulatta (rhesus monkey) ENSMUSP00000035129 Mus musculus (house mouse) 10376 Nematostella vectensis (starlet anemone) XP_001606593.1 Nasonia vitripennis (wasp) ENSOANP00000006279 Ornithorynchus anatinus (platypus) ENSORLP00000019993 Oryzias latipes (japanese killifish) LOC_Os01g12420.1 Oryza sativa (asian rice) PHUM003405-PA Pediculus humanus (human body louse) ENSPPYP00000015802 Pongo pygmaeus (orangutan) 568350 Populus trichocarpa (black cottonwood) ENSPTRP00000056656 Pan troglodytes (chimpanzee) ENSRNOP00000010634 Rattus norvegicus (norway rat) 5058774 Sorghum bicolor (sorghum) Smp_139480 Schistosoma mansoni (trematode parasite) XP_001196893.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001199846.1 Strongylocentrotus purpuratus (purple sea urchin) XP_966603.2 Tribolium castaneum (red flour beetle) ENSTNIP00000009289 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000017418 Takifugu rubripes (pufferfish Takifugu) 3717.m00027 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000016595 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/ephrtk1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43803 modMine - Data generated by the modENCODE project. • FBgn0025936 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11238 LH22870 ISCW022934 FBgn0232154 FBgn0215704 FBgn0201456 FBgn0195747 FBgn0181656 FBgn0181655 JGI_V11_104369 FBgn0243947 FBgn0155780 FBgn0136849 FBgn0131387 FBgn0108627 FBgn0099834 CPIJ014812 BGIBMGA002079 GB12585 AGAP000489 AAEL017107 AAEL010711 AAEL008301 PB23865 PHUM576020 GLEAN_06032
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG1511 (Morrison et al., 2000, Perkins et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) CT3831 (Hynes and Zhao, 2000, Hynes and Zhao, 2000) Dek (Stoker, 2002, He and Kunes, 1998) DEK (Boyle and Thomas, 2001, Palmer et al., 1999, Scully et al., 1999) dek (Nguyen et al., 2000, Scully, 1999.2.28, Scully et al., 1997, ) Dek7 (Scully, 1996.4.28) Deph (Bossing and Brand, 2002, Shibata and Bryant, 1998) Ek7   Eph (Boyle et al., 2006, Frank et al., 2009) eph (Stoker, 2002, Shibata, 1998.3.6, He, 1999.4.28, Zlatic et al., 2009) RPTK Dek7 (Scully et al., 1996)
Name Synonym	Drosophila eph (Shibata and Bryant, 1998) Eph kinase (Scully et al., 1999) Eph receptor (Tsuda et al., 2008, Frank et al., 2009) Eph receptor tyrosine kinase   Ephrin receptors (Banyai and Patthy, 2004)
Secondary FlyBase IDs
	FBgn0015726 FBgn0023093
References ( 47 )
Generate a list of	All references relating to this gene ( 47 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 7 ) Review  ( 3 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 5 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Curated genome annotation  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...