FB2019_05, released Oct 15, 2019

Gene: Dmel\Eph

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General Information
Symbol
Dmel\Eph
Species
D. melanogaster
Name
Eph receptor tyrosine kinase
Annotation Symbol
CG1511
Feature Type
protein_coding_gene
FlyBase ID
FBgn0025936
Gene Model Status
Current
Stock Availability
15 publicly available
Enzyme Name (EC)
Receptor protein-tyrosine kinase (2.7.10.1)
Gene Snapshot
Eph receptor tyrosine kinase (Eph) encodes an axon guidance molecule involved in the development of the nervous system. It also contributes to shaping the antero-posterior compartment boundary of the wing disc. [Date last reviewed: 2019-06-13]
Other Summaries
Also Known As
dek, lincRNA.923, Eph receptor, CT3831, Deph
Key Links
Genomic Location
Cytogenetic map
Sequence location
4:610,684..622,470 [+]
Recombination map
4-0
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
ATP binding; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.1)
Summaries
Gene Group (FlyBase)
RECEPTOR TYROSINE KINASES -
Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).
Summary (Interactive Fly)
receptor tyrosine kinase involved in axon pathfinding - functions in shaping of the wing compartment boundary
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
5

Please see the GBrowse view of Dmel\Eph or the JBrowse view of Dmel\Eph for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Alternative translation stop created by use of multiphasic reading frames within coding region.
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Eph-RA
FBtr0089082
NM_166775
4142
1080
Eph-RB
FBtr0089083
NM_166777
4068
1047
Eph-RC
FBtr0089084
NM_079886
4190
1096
Eph-RD
FBtr0089085
NM_166774
3691
1080
Eph-RE
FBtr0089086
NM_166776
5630
1080
Eph-RF
FBtr0301285
NM_001169353
3854
1005
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Eph-PA
FBpp0088151
121.5
1080
6.77
NP_726589
AAG22122
Eph-PB
FBpp0088152
117.9
1047
6.61
NP_726591
AAN06504
Eph-PC
FBpp0088153
123.3
1096
6.87
NP_524625
AAF59329
Eph-PD
FBpp0088154
121.7
1080
6.77
NP_726588
AAN06502
Eph-PE
FBpp0088155
121.5
1080
6.77
NP_726590
AAN06503
Eph-PF
FBpp0290500
112.9
1005
6.30
NP_001162824
ACZ95093
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1080 aa isoforms: Eph-PA, Eph-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Eph using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (13 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
ATP binding
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
transmembrane receptor protein tyrosine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
transmembrane-ephrin receptor activity
inferred from sequence or structural similarity with UniProtKB:P54762
(Scully et al., 1999)
inferred from biological aspect of ancestor with PANTHER:PTN000699977
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (7 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
melanotic encapsulation of foreign target
inferred from mutant phenotype
(Howell et al., 2012)
mushroom body development
inferred from mutant phenotype
(Boyle et al., 2006)
peripheral nervous system development
inferred from mutant phenotype
(Dearborn et al., 2012)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN000699977
(assigned by GO_Central )
(Gaudet et al., 2011)
ephrin receptor signaling pathway
inferred from sequence or structural similarity with UniProtKB:P54762
(Scully et al., 1999)
protein autophosphorylation
inferred from sequence or structural similarity with UniProtKB:P54762
(Scully et al., 1999)
transmembrane receptor protein tyrosine kinase signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with UniProtKB:P54762
(Scully et al., 1999)
neuron projection
inferred from biological aspect of ancestor with PANTHER:PTN000699977
(assigned by GO_Central )
(Gaudet et al., 2011)
receptor complex
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: higher concentration at posterior pole

(Scully et al., 1999)
embryonic stage 10
neurogenic region
(Scully et al., 1999)
embryonic stage 13 -- 17
presumptive embryonic/larval central nervous system
(Scully et al., 1999)
embryonic stage 16
neuron of ventral nerve cord
(Scully et al., 1999)
unfertilized egg stage
egg
(Scully et al., 1999)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval central nervous system
(Scully et al., 1999)
imaginal disc
(Scully et al., 1999)
pupal stage -- adult stage
organism
(Scully et al., 1999)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
neuron of ventral nerve cord
• axon
(Scully et al., 1999)
neuron of ventral nerve cord
(Scully et al., 1999)
embryonic stage 16
longitudinal connective
(Scully et al., 1999)
interneuron of ventral nerve cord
(Scully et al., 1999)
ventral nerve cord commissure
• axon
(Scully et al., 1999)
third instar larval stage
eye disc posterior to the morphogenetic furrow | uniform
(Dearborn et al., 2012)
lamina
(Dearborn et al., 2012)
medulla
(Dearborn et al., 2012)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Eph protein is expressed uniformly in the eye disc, posterior to the morphogenetic furrow. In the lamina, expression is highest at the posterior midline, and lowest at the dorsal-ventral margins of the anterior midline. Within the medulla, expression of Eph protein is the highest at the midline, decreasing along the dorsal-ventral axis.
(Dearborn et al., 2012)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Eph in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Eph
Transgenic constructs containing regulatory region of Eph
Deletions and Duplications ( 1 )
Partially disrupted in
Df(4)Ephx652
(Boyle et al., 2006)
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
partially lethal - majority die
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4A80
viable, with Scer\GAL4elav.PLu
viable, with Scer\GAL4elav.PLu, Scer\GAL4sca-537.4
viable, with Scer\GAL4elav-C155
viable, with Scer\GAL4ftz.ng
viable, with Scer\GAL4GMR.PF
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4sca-537.4
viable, with Scer\GAL4tin.CΔ4
viable | recessive
Sterility
Allele
female semi-sterile
female semi-sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
fertile | recessive
Other Phenotypes
Allele
immune response defective | larval stage
learning defective
neuroanatomy defective
neuroanatomy defective, with Scer\GAL4ap-md544
neuroanatomy defective, with Scer\GAL4bi-md653
neuroanatomy defective, with Scer\GAL4ey.PH
neuroanatomy defective, with Scer\GAL4αTub84B.PP
neuroanatomy defective | third instar larval stage
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4GMR.PU
Phenotype manifest in
Allele
cell body rind of lobula plate, with Scer\GAL4ey.PH
cell body rind of medulla, with Scer\GAL4ap-md544
cell body rind of medulla, with Scer\GAL4bi-md653
cell body rind of medulla, with Scer\GAL4ey.PH
cell body rind of medulla | somatic clone, with Scer\GAL4αTub84B.PP
embryonic/larval optic lobe, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PU
fascicle, with Scer\GAL4elav.PLu, Scer\GAL4sca-537.4
lobula | third instar larval stage
medial lobe of adult mushroom body
medulla anlage, with Scer\GAL4bi-md653
medulla anlage, with Scer\GAL4ey.PH
medulla anlage | third instar larval stage
photoreceptor cell & axon, with Scer\GAL4bi-md653
photoreceptor cell & axon, with Scer\GAL4ey.PH
photoreceptor cell R7 & axon | somatic clone, with Scer\GAL4αTub84B.PP
photoreceptor cell R8 & axon | somatic clone, with Scer\GAL4αTub84B.PP
vertical lobe of adult mushroom body
vertical lobe of adult mushroom body | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\EPHB1
14 of 15
Yes
Yes
 
Hsap\EPHB2
13 of 15
Yes
No
Hsap\EPHA4
12 of 15
Yes
No
Hsap\EPHA5
12 of 15
Yes
No
Hsap\EPHA7
12 of 15
Yes
No
Hsap\EPHB3
12 of 15
Yes
No
Hsap\EPHA3
11 of 15
Yes
No
Hsap\EPHA8
11 of 15
Yes
No
Hsap\EPHB4
11 of 15
Yes
No
Hsap\EPHA2
10 of 15
Yes
No
Hsap\EPHA6
10 of 15
No
Yes
Hsap\EPHB6
9 of 15
Yes
No
Hsap\EPHA1
7 of 15
Yes
No
 
Hsap\EPHA10
6 of 15
No
Yes
Hsap\AXL
1 of 15
Yes
No
Hsap\INSR
1 of 15
No
No
 
Hsap\INSRR
1 of 15
No
No
Hsap\TYRO3
1 of 15
Yes
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ephb1
14 of 15
Yes
Yes
Mmus\Ephb2
12 of 15
Yes
No
Mmus\Epha4
11 of 15
Yes
No
Mmus\Epha7
11 of 15
Yes
No
Mmus\Epha2
10 of 15
Yes
No
Mmus\Epha3
10 of 15
Yes
No
Mmus\Ephb3
10 of 15
Yes
No
Mmus\Ephb4
10 of 15
Yes
No
Mmus\Epha5
9 of 15
Yes
No
Mmus\Epha6
9 of 15
Yes
No
Mmus\Epha8
9 of 15
Yes
No
Mmus\Ephb6
9 of 15
Yes
No
Mmus\Epha1
7 of 15
Yes
No
Mmus\Epha10
5 of 15
No
Yes
Mmus\Axl
1 of 15
Yes
No
Mmus\Insr
1 of 15
No
No
Mmus\Insrr
1 of 15
No
No
Mmus\Tyro3
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (16)
Rnor\Ephb1
13 of 13
Yes
Yes
Rnor\Ephb2
12 of 13
No
Yes
Rnor\Ephb3
12 of 13
No
Yes
Rnor\Epha4
11 of 13
No
Yes
Rnor\Epha5
11 of 13
No
Yes
Rnor\Epha7
11 of 13
No
Yes
Rnor\Epha3
10 of 13
Yes
No
Rnor\Ephb6
10 of 13
No
Yes
Rnor\Epha1
7 of 13
No
Yes
Rnor\Epha2
7 of 13
No
Yes
Rnor\Epha8
7 of 13
No
Yes
Rnor\Epha10
7 of 13
No
Yes
Rnor\Ephb4
6 of 13
No
Yes
Rnor\Epha6
5 of 13
Yes
No
Rnor\Insr
1 of 13
No
No
Rnor\Tyro3
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (13)
Xtro\ephb1
8 of 12
Yes
Yes
Xtro\ephb3
7 of 12
No
Yes
Xtro\epha4
6 of 12
No
Yes
Xtro\epha3
5 of 12
No
Yes
Xtro\ephb4
5 of 12
No
Yes
Xtro\epha6
4 of 12
No
Yes
Xtro\epha7
4 of 12
No
Yes
Xtro\epha2
3 of 12
No
Yes
Xtro\epha8
2 of 12
No
Yes
Xtro\epha10
2 of 12
No
Yes
Xtro\epha5
1 of 12
No
Yes
Xtro\LOC100494929
1 of 12
No
Yes
Xtro\LOC108645837
1 of 12
No
Yes
Danio rerio (Zebrafish) (22)
Drer\epha7
11 of 15
Yes
Yes
Drer\ephb1
11 of 15
Yes
Yes
Drer\ephb2b
11 of 15
Yes
Yes
Drer\epha4b
10 of 15
No
Yes
Drer\epha4l
10 of 15
Yes
No
Drer\epha8
10 of 15
No
Yes
Drer\ephb3b
10 of 15
No
Yes
Drer\ephb4a
10 of 15
Yes
No
Drer\ek1
9 of 15
Yes
No
Drer\epha3
9 of 15
No
Yes
Drer\ephb2a
9 of 15
No
Yes
Drer\ephb6
9 of 15
No
Yes
Drer\epha4a
8 of 15
No
Yes
Drer\epha5
8 of 15
No
Yes
Drer\epha6
8 of 15
No
Yes
Drer\ephb4b
8 of 15
Yes
No
Drer\epha2a
7 of 15
Yes
No
Drer\ephb3a
7 of 15
Yes
No
Drer\epha2b
6 of 15
No
Yes
Drer\LOC572450
2 of 15
No
Yes
Drer\LOC100329589
1 of 15
No
Yes
Drer\tek
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\vab-1
10 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (96)
Atha\AT1G05700
1 of 9
Yes
Yes
Atha\AT1G06840
1 of 9
Yes
Yes
Atha\AT1G07550
1 of 9
Yes
Yes
Atha\AT1G07560
1 of 9
Yes
Yes
Atha\AT1G07650
1 of 9
Yes
Yes
Atha\AT1G10850
1 of 9
Yes
Yes
Atha\AT1G27190
1 of 9
Yes
Yes
Atha\AT1G29720
1 of 9
Yes
Yes
Atha\AT1G29740
1 of 9
Yes
Yes
Atha\AT1G49100
1 of 9
Yes
Yes
Atha\AT1G51790
1 of 9
Yes
Yes
Atha\AT1G51805
1 of 9
Yes
Yes
Atha\AT1G51810
1 of 9
Yes
Yes
Atha\AT1G51820
1 of 9
Yes
Yes
Atha\AT1G51830
1 of 9
Yes
Yes
Atha\AT1G51850
1 of 9
Yes
Yes
Atha\AT1G51860
1 of 9
Yes
Yes
Atha\AT1G51890
1 of 9
Yes
Yes
Atha\AT1G51910
1 of 9
Yes
Yes
Atha\AT1G53430
1 of 9
Yes
Yes
Atha\AT1G53440
1 of 9
Yes
Yes
Atha\AT1G56120
1 of 9
Yes
Yes
Atha\AT1G56130
1 of 9
Yes
Yes
Atha\AT1G56140
1 of 9
Yes
Yes
Atha\AT1G56145
1 of 9
Yes
Yes
Atha\AT1G64210
1 of 9
Yes
Yes
Atha\AT1G67510
1 of 9
Yes
Yes
Atha\AT1G67720
1 of 9
Yes
Yes
Atha\AT1G68400
1 of 9
Yes
Yes
Atha\AT1G69990
1 of 9
Yes
Yes
Atha\AT1G73660
1 of 9
Yes
No
Atha\AT1G79620
1 of 9
Yes
Yes
Atha\AT2G04300
1 of 9
Yes
Yes
Atha\AT2G14440
1 of 9
Yes
Yes
Atha\AT2G14510
1 of 9
Yes
Yes
Atha\AT2G19210
1 of 9
Yes
Yes
Atha\AT2G19230
1 of 9
Yes
Yes
Atha\AT2G23950
1 of 9
Yes
Yes
Atha\AT2G26730
1 of 9
Yes
Yes
Atha\AT2G28960
1 of 9
Yes
Yes
Atha\AT2G28970
1 of 9
Yes
Yes
Atha\AT2G28990
1 of 9
Yes
Yes
Atha\AT2G29000
1 of 9
Yes
Yes
Atha\AT3G02880
1 of 9
Yes
Yes
Atha\AT3G03770
1 of 9
Yes
Yes
Atha\AT3G14840
1 of 9
Yes
Yes
Atha\AT3G21340
1 of 9
Yes
Yes
Atha\AT3G28450
1 of 9
Yes
Yes
Atha\AT3G46370
1 of 9
Yes
Yes
Atha\AT3G46400
1 of 9
Yes
Yes
Atha\AT3G46420
1 of 9
Yes
Yes
Atha\AT3G53590
1 of 9
Yes
Yes
Atha\AT4G20450
1 of 9
Yes
Yes
Atha\AT4G22730
1 of 9
Yes
Yes
Atha\AT4G23740
1 of 9
Yes
Yes
Atha\AT4G29450
1 of 9
Yes
Yes
Atha\AT5G01950
1 of 9
Yes
Yes
Atha\AT5G10290
1 of 9
Yes
Yes
Atha\AT5G16590
1 of 9
Yes
Yes
Atha\AT5G16900
1 of 9
Yes
Yes
Atha\AT5G37450
1 of 9
Yes
Yes
Atha\AT5G45780
1 of 9
Yes
Yes
Atha\AT5G49760
1 of 9
Yes
Yes
Atha\AT5G49770
1 of 9
Yes
Yes
Atha\AT5G49780
1 of 9
Yes
Yes
Atha\AT5G58300
1 of 9
Yes
Yes
Atha\AT5G59650
1 of 9
Yes
Yes
Atha\AT5G59660
1 of 9
Yes
Yes
Atha\AT5G59670
1 of 9
Yes
Yes
Atha\AT5G59680
1 of 9
Yes
Yes
Atha\AT5G61560
1 of 9
Yes
Yes
Atha\AT5G62710
1 of 9
Yes
Yes
Atha\AT5G63710
1 of 9
Yes
Yes
Atha\BAK1
1 of 9
Yes
Yes
Atha\EDR1
1 of 9
Yes
No
Atha\FEI2
1 of 9
Yes
Yes
Atha\FRK1
1 of 9
Yes
Yes
Atha\IOS1
1 of 9
Yes
Yes
Atha\MEE39
1 of 9
Yes
Yes
Atha\MRLK
1 of 9
Yes
Yes
Atha\NIK1
1 of 9
Yes
Yes
Atha\NIK2
1 of 9
Yes
Yes
Atha\NIK3
1 of 9
Yes
Yes
Atha\RHS6
1 of 9
Yes
Yes
Atha\RHS16
1 of 9
Yes
Yes
Atha\RLK902
1 of 9
Yes
Yes
Atha\RPK1
1 of 9
Yes
Yes
Atha\SARK
1 of 9
Yes
Yes
Atha\SERK4
1 of 9
Yes
Yes
Atha\SRF2
1 of 9
Yes
Yes
Atha\SRF3
1 of 9
Yes
Yes
Atha\SRF4
1 of 9
Yes
Yes
Atha\SRF5
1 of 9
Yes
Yes
Atha\SRF6
1 of 9
Yes
Yes
Atha\TMK1
1 of 9
Yes
Yes
Atha\YDA
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\KIN1
1 of 15
Yes
No
Scer\SCH9
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919017P )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Eph
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007095
Drosophila simulans
Dsim\GD24409
Drosophila sechellia
Dsec\GM26803
Drosophila sechellia
Dsec\GM26804
Drosophila erecta
Dere\GG16395
Drosophila yakuba
Dyak\GE14555
Drosophila ananassae
Dana\GF22840
Drosophila pseudoobscura pseudoobscura
Dpse\GA22544
Drosophila persimilis
Dper\GL18177
Drosophila willistoni
Dwil\GK13696
Drosophila virilis
Dvir\GJ14241
Drosophila mojavensis
Dmoj\GI14095
Drosophila grimshawi
Dgri\GH23930
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500PL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015153
Glossina morsitans
Tsetse fly
Gmor\GMOY000413
Glossina morsitans
Tsetse fly
Gmor\GMOY011352
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07520
Mayetiola destructor
Hessian fly
Mdes\Mdes004538
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010711
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008301
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL017107
Anopheles darlingi
American malaria mosquito
Adar\ADAC004174
Anopheles gambiae
Malaria mosquito
Agam\AGAP000489
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014812
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00UH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002079
Danaus plexippus
Monarch butterfly
Dple\DPOGS203319-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008812
Apis florea
Little honeybee
Aflo\2147490449
Apis florea
Little honeybee
Aflo\5047849140
Apis mellifera
Western honey bee
Amel\GB41629
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12060
Bombus terrestris
Buff-tailed bumblebee
Bter\15207509
Linepithema humile
Argentine ant
Lhum\LH22870
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00112a
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002872
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11051
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11050
Tribolium castaneum
Red flour beetle
Tcas\TC033957
Pediculus humanus
Human body louse
Phum\PHUM576020
Rhodnius prolixus
Kissing bug
Rpro\RPRC012412
Cimex lectularius
Bed bug
Clec\CLEC002032
Cimex lectularius
Bed bug
Clec\CLEC002033
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI064034
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01541
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00T5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002974
Ixodes scapularis
Black-legged tick
Isca\ISCW022934
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62390.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur38g00020
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_104369
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00W0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Eph
Ciona intestinalis
Vase tunicate
Cint\ephg
Ciona intestinalis
Vase tunicate
Cint\eph-like
Ciona intestinalis
Vase tunicate
Cint\ephd
Ciona intestinalis
Vase tunicate
Cint\ephe
Ciona intestinalis
Vase tunicate
Cint\LOC100175579
Ciona intestinalis
Vase tunicate
Cint\eph3
Gallus gallus
Domestic chicken
Ggal\EPHB6
Gallus gallus
Domestic chicken
Ggal\EPHA10
Gallus gallus
Domestic chicken
Ggal\EPHB3
Gallus gallus
Domestic chicken
Ggal\EPHA2
Gallus gallus
Domestic chicken
Ggal\EPHB1
Gallus gallus
Domestic chicken
Ggal\EPHA3
Gallus gallus
Domestic chicken
Ggal\EPHB2
Gallus gallus
Domestic chicken
Ggal\EPHA6
Gallus gallus
Domestic chicken
Ggal\EPHA8
Gallus gallus
Domestic chicken
Ggal\EPHA5
Gallus gallus
Domestic chicken
Ggal\EPHA1
Gallus gallus
Domestic chicken
Ggal\EPHA7
Gallus gallus
Domestic chicken
Ggal\EPHA4
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (19)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Alk
1 of 10
btl
1 of 10
Cad96Ca
1 of 10
CG3277
1 of 10
CG10702
1 of 10
Ddr
1 of 10
dnt
1 of 10
Drl-2
1 of 10
drl
1 of 10
Egfr
1 of 10
htl
1 of 10
InR
1 of 10
Nrk
1 of 10
Pvr
1 of 10
Ret
1 of 10
Ror
1 of 10
sev
1 of 10
Tie
1 of 10
tor
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    EPHA2; EPH receptor A2
    model of  cataract 6 multiple types
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    EPHB1; EPH receptor B1
    14 of 15
    600600
         
        EPHB2; EPH receptor B2
        13 of 15
        600997
          EPHA4; EPH receptor A4
          12 of 15
          602188
              EPHA5; EPH receptor A5
              12 of 15
              600004
                  EPHA7; EPH receptor A7
                  12 of 15
                  602190
                      EPHB3; EPH receptor B3
                      12 of 15
                      601839
                          EPHA3; EPH receptor A3
                          11 of 15
                          179611
                              EPHA8; EPH receptor A8
                              11 of 15
                              176945
                                  EPHB4; EPH receptor B4
                                  11 of 15
                                  600011
                                    EPHA2; EPH receptor A2
                                    10 of 15
                                    176946
                                    EPHA6; EPH receptor A6
                                    10 of 15
                                    600066
                                        EPHB6; EPH receptor B6
                                        9 of 15
                                        602757
                                            EPHA1; EPH receptor A1
                                            7 of 15
                                            179610
                                                 
                                                EPHA10; EPH receptor A10
                                                6 of 15
                                                611123
                                                    Functional Complementation Data
                                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                    Interactions
                                                    Summary of Physical Interactions
                                                    esyN Network Diagram
                                                    Show neighbor-neighbor interactions:
                                                    Select Layout:
                                                    Legend:
                                                    Protein
                                                    RNA
                                                    Selected Interactor(s)
                                                    Interactions Browser
                                                    View in Interactions Browser
                                                    Please see the Physical Interaction reports below for full details
                                                    protein-protein
                                                    Physical Interaction
                                                    Assay
                                                    References
                                                    Eph - Ephrin
                                                    bead aggregation assay, fluorescence microscopy, inferred by author
                                                    (Bossing and Brand, 2002)
                                                    Eph - Exn
                                                    two hybrid
                                                    (Frank et al., 2009)
                                                    Summary of Genetic Interactions
                                                    esyN Network Diagram
                                                    esyN Network Key:
                                                    Suppression
                                                    Enhancement
                                                    View in Interactions Browser
                                                    Please look at the allele data for full details of the genetic interactions
                                                    Starting gene(s)
                                                    Interaction type
                                                    Interacting gene(s)
                                                    Reference
                                                    Eph
                                                    enhanceable
                                                    Reph
                                                    (Dearborn et al., 2012, Bettencourt da Cruz et al., 2008)
                                                    Starting gene(s)
                                                    Interaction type
                                                    Interacting gene(s)
                                                    Reference
                                                    Ephrin
                                                    suppressible
                                                    Eph
                                                    (Dearborn et al., 2012, Boyle et al., 2006, Dearborn et al., 2002)
                                                    GluRIIA
                                                    suppressible
                                                    Eph
                                                    (Frank et al., 2009)
                                                    GluRIIA
                                                    suppressible
                                                    Eph|Exn
                                                    (Frank et al., 2009)
                                                    meigo
                                                    enhanceable
                                                    Eph
                                                    (Sekine et al., 2013)
                                                    Vap33
                                                    suppressible
                                                    Eph
                                                    (Tsuda et al., 2008)
                                                    External Data
                                                    Linkouts
                                                    BioGRID - A database of protein and genetic interactions.
                                                    DroID - A comprehensive database of gene and protein interactions.
                                                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                                    MIST (genetic) - An integrated Molecular Interaction Database
                                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                                    Pathways
                                                    Genomic Location and Detailed Mapping Data
                                                    Chromosome (arm)
                                                    4
                                                    Recombination map
                                                    4-0
                                                    Cytogenetic map
                                                    102D1-102D1
                                                    Sequence location
                                                    4:610,684..622,470 [+]
                                                    FlyBase Computed Cytological Location
                                                    Cytogenetic map
                                                    Evidence for location
                                                    102D1-102D1
                                                    Experimentally Determined Cytological Location
                                                    Cytogenetic map
                                                    Notes
                                                    References
                                                    102C6-102C6
                                                    (Scully, 1999.2.28)
                                                    102C-102C
                                                    (He, 1999.4.28)
                                                    102C6-102C6
                                                    (determined by in situ hybridisation)
                                                    (Scully et al., 1999)
                                                    Experimentally Determined Recombination Data
                                                    Location
                                                    4-0
                                                    (FlyBase, 2016)
                                                    Left of (cM)
                                                    Right of (cM)
                                                    Notes
                                                    Stocks and Reagents
                                                    Stocks (15)
                                                    Genomic Clones (19)
                                                    cDNA Clones (183)
                                                     

                                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                    cDNA clones, fully sequences
                                                    BDGP DGC clones
                                                    Other clones
                                                    Drosophila Genomics Resource Center cDNA clones

                                                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                    cDNA Clones, End Sequenced (ESTs)
                                                    BDGP DGC clones
                                                    Other clones
                                                    RNAi and Array Information
                                                    Linkouts
                                                    DRSC - Results frm RNAi screens
                                                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                                    Antibody Information
                                                    Laboratory Generated Antibodies
                                                     
                                                    polyclonal
                                                    (Franco and Carmena, 2019, Scully et al., 1999)
                                                    Commercially Available Antibodies
                                                     
                                                    Other Information
                                                    Relationship to Other Genes
                                                    Source for database identify of
                                                    Source for identity of: Eph CG1511
                                                    (Zhong, 1999.11)
                                                    Source for database merge of
                                                    Additional comments
                                                    Other Comments
                                                    Eph/Ephrin signalling acts to guide a subset of mushroom body branches to their correct synaptic targets.
                                                    (Boyle et al., 2006)
                                                    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
                                                    (Kiger et al., 2003)
                                                    Identification: PCR screen using degenerate primers to conserved regions within the kinase domain of RTKs.
                                                    (Scully et al., 1997)
                                                    Identification: recovered from a PCR-based screen for receptor tyrosine kinase encoding genes.
                                                    (Scully et al., 1996)
                                                    Dek7 is given as a temporary designation.
                                                    (Scully, 1996.4.28)
                                                    Origin and Etymology
                                                    Discoverer
                                                    Etymology
                                                    Identification
                                                    External Crossreferences and Linkouts ( 92 )
                                                    Sequence Crossreferences
                                                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                    Other crossreferences
                                                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                    Flygut - An atlas of the Drosophila adult midgut
                                                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                    InterPro - A database of protein families, domains and functional sites
                                                    KEGG Genes - Molecular building blocks of life in the genomic space.
                                                    modMine - A data warehouse for the modENCODE project
                                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                    Linkouts
                                                    BioGRID - A database of protein and genetic interactions.
                                                    DroID - A comprehensive database of gene and protein interactions.
                                                    DRSC - Results frm RNAi screens
                                                    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                    FlyMine - An integrated database for Drosophila genomics
                                                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                                    MIST (genetic) - An integrated Molecular Interaction Database
                                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                    Synonyms and Secondary IDs (17)
                                                    Reported As
                                                    Symbol Synonym
                                                    CG1511
                                                    (Koya and Meller, 2015, Howell et al., 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Schiess et al., 2009, Morrison et al., 2000)
                                                    CT3831
                                                    (Hynes and Zhao, 2000, Hynes and Zhao, 2000)
                                                    DEK
                                                    (Boyle and Thomas, 2001, Palmer et al., 1999, Scully et al., 1999)
                                                    Dek
                                                    (Sopko and Perrimon, 2013, Stoker, 2002, He and Kunes, 1998)
                                                    Dek7
                                                    (Scully, 1996.4.28)
                                                    Deph
                                                    (Bossing and Brand, 2002, Shibata and Bryant, 1998)
                                                    Ek7
                                                    Eph
                                                    (Dourlen et al., 2018, Levis, 2018.8.30, Dourlen et al., 2017, Early et al., 2017, Stessman et al., 2017, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Sarov et al., 2016, Koya and Meller, 2015, Ugrankar et al., 2015, Ashwal-Fluss et al., 2014, Frank, 2014, Sopko et al., 2014, Kwon et al., 2013, Ozkan et al., 2013, Sekine et al., 2013, Sopko and Perrimon, 2013, Zhang et al., 2013, Dearborn et al., 2012, Howell et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Deng et al., 2009, Frank et al., 2009, Tsuda et al., 2008, Boyle et al., 2006, Pickeral et al., 2000)
                                                    RPTK Dek7
                                                    (Scully et al., 1996)
                                                    dek
                                                    (Nguyen et al., 2000, Scully, 1999.2.28, Scully et al., 1997)
                                                    eph
                                                    (Liu et al., 2017, Iyer et al., 2016, Zlatic et al., 2009, Stoker, 2002, He, 1999.4.28, Shibata, 1998.3.6)
                                                    lincRNA.923
                                                    (FlyBase Genome Annotators, 2014, Young et al., 2012)
                                                    Name Synonyms
                                                    Drosophila eph
                                                    (Shibata and Bryant, 1998)
                                                    Eph kinase
                                                    (Scully et al., 1999)
                                                    Eph receptor
                                                    (Frank et al., 2009, Tsuda et al., 2008)
                                                    Eph receptor tyrosine kinase
                                                    Ephrin receptors
                                                    (Banyai and Patthy, 2004)
                                                    Secondary FlyBase IDs
                                                    • FBgn0015726
                                                    • FBgn0023093
                                                    Datasets (0)
                                                    Study focus (0)
                                                    Experimental Role
                                                    Project
                                                    Project Type
                                                    Title
                                                    References (105)