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Gene Dmel\Mhcl

General Information
Symbol	Dmel\Mhcl	Species	D. melanogaster
Name	Myosin heavy chain-like	Annotation symbol	CG31045
Feature type	protein_coding_gene	FlyBase ID	FBgn0026059
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	CG10218
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	89B2-89B3	Sequence location	3R:11,894,245..11,924,483 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Myosin heavy chain-like is referred to in FlyBase by the symbol Dmel\Mhcl (CG31045, FBgn0026059). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATPase activity, coupled. The biological processes in which it is involved are not known. 7 alleles are reported. The phenotypes of these alleles are annotated with: ventral nerve cord; peripheral nervous system. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: IQ motif, EF-hand binding site; Myosin head, motor domain; Myosin tail; PDZ domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult salivary gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632231_a_at completely aligns to an exonic region common to each of the 6 FlyBase-annotated transcript isoforms of Mhcl. Gene sequence location is 3R:11894245..11924483.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms actin filament binding microfilament motor activity biological_process actin-dependent ATPase activity
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89B2-89B3   Limits computationally determined from genome sequence between P{PZ}blp01618 and P{PZ}gish04895&P{EP}EP3171
Experimentally Determined Cytological Location
Cytogenetic map Notes References 89B-89B     (Biru, 1999.1.28)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mhcl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-Seq exon junction(s) not annotated. Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mhcl-RA FBtr0083229  NM_169700   6686   2148 Mhcl-RB FBtr0083231  NM_169701   7418   2194 Mhcl-RC FBtr0083232  NM_170650   2923   920 Mhcl-RD FBtr0083233  NM_169703   4004   1134 Mhcl-RF FBtr0110973  NM_001043251   6509   1923 Mhcl-RG FBtr0110974  NM_001043250   6782   2160 Mhcl-RH FBtr0303845  NM_001202304   2015   533 Mhcl-RI FBtr0332439  NM_001275694   3941   1113
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mhcl-PA   FBpp0082683   240.1   2148   6.60     NP_732108   AAF55271 Mhcl-PB   FBpp0082685   244.8   2194   6.70     NP_732109   AAN13695 Mhcl-PC   FBpp0082686   106.7   920   5.19     NP_732110   AAN13696 Mhcl-PD   FBpp0082687   128.7   1134   5.26     NP_732111   AAN13697 Mhcl-PF   FBpp0110273   215.6   1923   7.04     NP_001036716   ABI31172 Mhcl-PG   FBpp0110274   241.6   2160   6.62     NP_001036715   ABI31171 Mhcl-PH   FBpp0292853   62.0   533   4.92     NP_001189233   ADV37324 Mhcl-PI   FBpp0304712   126.4   1113   5.29     NP_001262623   AGB96003
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • IQ motif, EF-hand binding site (IPR000048) PDZ domain (IPR001478) Myosin head, motor domain (IPR001609) Myosin-like IQ motif-containing domain (IPR027401) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Myosin tail (IPR002928)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA803221   AE014297 AAF55271   AE014297 AAN13695   AE014297 AAN13696   AE014297 AAN13697   AE014297 ABI31171   AE014297 ABI31172   AE014297 ADV37324   AF454347 AAL87864   AE014297 AGB96003   AI061870   AI064490   AI257058   AI260573   AI292545   AI292965   AI294912   AI295514   AI389193   AI402760   AJ132656 CAA10724   AW940592   AW944098   AY051503 AAK92927   AY069747   BF487693   BF488142   BF492308   BF501735   BF501868   BF504018   BG633109   BI164947   BI227719   BI235117   BI363248   BT001428 AAN71183   BT030433   CK659321   CO152738   CO154355   CO185316   CO185645   CO185670   CO190592   CO273289   CO273339   CO278202   CO281917   CO283953   CO285052   CO286684   CO288335   CO293268   CO296826   CO297306   CO298606   CO301909   CO302649   CO305521   CO306065   CO314693   CO317122   CO318310   CO319592   CO319782   CO325751   CO328099   CO329241   CO331449   CO333377   CO334048   CO340250   CO340302   CZ469761   CZ469762   CZ481454   EC056914   EC057124   EC060454   EC063770   EC064437   EC065959   EC066585   EC068549   EC068568   EC073031   EC075177   EC075235   EC088363   EC089682   EC090179   EC091107   EC196209   EC198288   EC204583   EC209985   EC211736   EC215846   EC216715   EC229947   EC235341   EC235708   EC235791   EC239597   EC239612   EC241371   EC247691   EC251335   EC257035   EC258143   EC259729   EC260739   EC262617   EC263757   EG974093   EL886888   EL886957   EL887017   EL887205   EL887258   ES693980   ES695443   EV574904   EV587361   GH968633
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IH49 Q8INC1 Q8INC3 Q9VEZ0 Q0KI67 Q0KI66 Q8T6M0 O96816 Q7K523
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   anlage in statu nascendi   (Fisher et al., 2012) dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi posterior ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 7 -- 8   amnioserosa anlage   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   dorsal ectoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   dorsal epidermis primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult salivary gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    24.2 Larval Midgut    19.7 Larval Hindgut    46.4 Larval Malpighian Tubules    37.4 Larval Fat Body    41.8 Larval Salivary Gland    9.7 Larval Trachea    32.375 Larval Carcass    136.075 Adult Head    65.6 Adult Eye    403.525 Adult Brain    48.8 Adult Thoracic-Abdominal Ganglion    33.9 Adult Crop    126.4 Adult Midgut    20.8 Adult Hindgut    36.7 Adult Malpighian Tubules    19.5 Adult Fat Body    21.8 Adult Salivary Gland    101.1 Adult Heart    56.05 Adult VirginFemale Spermatheca    14.5 Adult InseminatedFemale Spermatheca    14.1 Adult Ovary    35.3 Adult Testis    32.9 Adult Male Accessory Gland    42.1 Adult Carcass    37.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    24.2 Larval Midgut    19.7 Larval Hindgut    46.4 Larval Malpighian Tubules    37.4 Larval Fat Body    41.8 Larval Salivary Gland    9.7 Larval Trachea    32.375 Larval Carcass    136.075 Adult Head    65.6 Adult Eye    403.525 Adult Brain    48.8 Adult Thoracic-Abdominal Ganglion    33.9 Adult Crop    126.4 Adult Midgut    20.8 Adult Hindgut    36.7 Adult Malpighian Tubules    19.5 Adult Fat Body    21.8 Adult Salivary Gland    101.1 Adult Heart    56.05 Adult VirginFemale Spermatheca    14.5 Adult InseminatedFemale Spermatheca    14.1 Adult Ovary    35.3 Adult Testis    32.9 Adult Male Accessory Gland    42.1 Adult Carcass    37.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    24.2 Larval Midgut    19.7 Larval Hindgut    46.4 Larval Malpighian Tubules    37.4 Larval Fat Body    41.8 Larval Salivary Gland    9.7 Larval Trachea    32.375 Larval Carcass    136.075 Adult Head    65.6 Adult Eye    403.525 Adult Brain    48.8 Adult Thoracic-Abdominal Ganglion    33.9 Adult Crop    126.4 Adult Midgut    20.8 Adult Hindgut    36.7 Adult Malpighian Tubules    19.5 Adult Fat Body    21.8 Adult Salivary Gland    101.1 Adult Heart    56.05 Adult VirginFemale Spermatheca    14.5 Adult InseminatedFemale Spermatheca    14.1 Adult Ovary    35.3 Adult Testis    32.9 Adult Male Accessory Gland    42.1 Adult Carcass    37.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    24.2 Larval Midgut    19.7 Larval Hindgut    46.4 Larval Malpighian Tubules    37.4 Larval Fat Body    41.8 Larval Salivary Gland    9.7 Larval Trachea    32.375 Larval Carcass    136.075 Adult Head    65.6 Adult Eye    403.525 Adult Brain    48.8 Adult Thoracic-Abdominal Ganglion    33.9 Adult Crop    126.4 Adult Midgut    20.8 Adult Hindgut    36.7 Adult Malpighian Tubules    19.5 Adult Fat Body    21.8 Adult Salivary Gland    101.1 Adult Heart    56.05 Adult VirginFemale Spermatheca    14.5 Adult InseminatedFemale Spermatheca    14.1 Adult Ovary    35.3 Adult Testis    32.9 Adult Male Accessory Gland    42.1 Adult Carcass    37.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    24.2 Larval Midgut    19.7 Larval Hindgut    46.4 Larval Malpighian Tubules    37.4 Larval Fat Body    41.8 Larval Salivary Gland    9.7 Larval Trachea    32.375 Larval Carcass    136.075 Adult Head    65.6 Adult Eye    403.525 Adult Brain    48.8 Adult Thoracic-Abdominal Ganglion    33.9 Adult Crop    126.4 Adult Midgut    20.8 Adult Hindgut    36.7 Adult Malpighian Tubules    19.5 Adult Fat Body    21.8 Adult Salivary Gland    101.1 Adult Heart    56.05 Adult VirginFemale Spermatheca    14.5 Adult InseminatedFemale Spermatheca    14.1 Adult Ovary    35.3 Adult Testis    32.9 Adult Male Accessory Gland    42.1 Adult Carcass    37.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    24.2 Larval Midgut    19.7 Larval Hindgut    46.4 Larval Malpighian Tubules    37.4 Larval Fat Body    41.8 Larval Salivary Gland    9.7 Larval Trachea    32.375 Larval Carcass    136.075 Adult Head    65.6 Adult Eye    403.525 Adult Brain    48.8 Adult Thoracic-Abdominal Ganglion    33.9 Adult Crop    126.4 Adult Midgut    20.8 Adult Hindgut    36.7 Adult Malpighian Tubules    19.5 Adult Fat Body    21.8 Adult Salivary Gland    101.1 Adult Heart    56.05 Adult VirginFemale Spermatheca    14.5 Adult InseminatedFemale Spermatheca    14.1 Adult Ovary    35.3 Adult Testis    32.9 Adult Male Accessory Gland    42.1 Adult Carcass    37.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    24.2 Larval Midgut    19.7 Larval Hindgut    46.4 Larval Malpighian Tubules    37.4 Larval Fat Body    41.8 Larval Salivary Gland    9.7 Larval Trachea    32.375 Larval Carcass    136.075 Adult Head    65.6 Adult Eye    403.525 Adult Brain    48.8 Adult Thoracic-Abdominal Ganglion    33.9 Adult Crop    126.4 Adult Midgut    20.8 Adult Hindgut    36.7 Adult Malpighian Tubules    19.5 Adult Fat Body    21.8 Adult Salivary Gland    101.1 Adult Heart    56.05 Adult VirginFemale Spermatheca    14.5 Adult InseminatedFemale Spermatheca    14.1 Adult Ovary    35.3 Adult Testis    32.9 Adult Male Accessory Gland    42.1 Adult Carcass    37.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    24.2 Larval Midgut    19.7 Larval Hindgut    46.4 Larval Malpighian Tubules    37.4 Larval Fat Body    41.8 Larval Salivary Gland    9.7 Larval Trachea    32.375 Larval Carcass    136.075 Adult Head    65.6 Adult Eye    403.525 Adult Brain    48.8 Adult Thoracic-Abdominal Ganglion    33.9 Adult Crop    126.4 Adult Midgut    20.8 Adult Hindgut    36.7 Adult Malpighian Tubules    19.5 Adult Fat Body    21.8 Adult Salivary Gland    101.1 Adult Heart    56.05 Adult VirginFemale Spermatheca    14.5 Adult InseminatedFemale Spermatheca    14.1 Adult Ovary    35.3 Adult Testis    32.9 Adult Male Accessory Gland    42.1 Adult Carcass    37.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    65.6   NA  Eye    403.525   NA  Brain    48.8   24.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    33.9   NA  Crop    126.4   no informative data  Midgut    no informative data   46.4  Hindgut    36.7   37.4  Malpighian Tubules    no informative data   41.8  Fat Body    21.8   9.7  Salivary Gland    101.1   NA  Heart    56.05   32.375  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    14.1   NA  Ovary    35.3   NA  Testis    32.9   NA  Male Accessory Gland    42.1   136.075  Carcass    37.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    12 central nervous system, pupae P8    22 head, virgin 1-day female    23 head, virgin 4-day female    19 head, virgin 20-day female    13 head, mated 1-day female    21 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    35 head, mated 4-day male    25 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    14 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    12 central nervous system, pupae P8    22 head, virgin 1-day female    23 head, virgin 4-day female    19 head, virgin 20-day female    13 head, mated 1-day female    21 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male  (35) head, mated 4-day male    25 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    14 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    12 central nervous system, pupae P8    22 head, virgin 1-day female    23 head, virgin 4-day female    19 head, virgin 20-day female    13 head, mated 1-day female    21 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    35 head, mated 4-day male    25 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    14 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    12 central nervous system, pupae P8    22 head, virgin 1-day female    23 head, virgin 4-day female    19 head, virgin 20-day female    13 head, mated 1-day female    21 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    35 head, mated 4-day male    25 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    14 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    12 central nervous system, pupae P8    22 head, virgin 1-day female    23 head, virgin 4-day female    19 head, virgin 20-day female    13 head, mated 1-day female    21 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    35 head, mated 4-day male    25 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    14 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    12 central nervous system, pupae P8    22 head, virgin 1-day female    23 head, virgin 4-day female    19 head, virgin 20-day female    13 head, mated 1-day female    21 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male  (35) head, mated 4-day male    25 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    14 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    12 central nervous system, pupae P8    22 head, virgin 1-day female    23 head, virgin 4-day female    19 head, virgin 20-day female    13 head, mated 1-day female    21 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    35 head, mated 4-day male    25 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    14 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    12 central nervous system, pupae P8    22 head, virgin 1-day female    23 head, virgin 4-day female    19 head, virgin 20-day female    13 head, mated 1-day female    21 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    35 head, mated 4-day male    25 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    14 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    24 embryo 08-10hr    23 embryo 10-12hr    31 embryo 12-14hr    31 embryo 14-16hr    33 embryo 16-18hr    20 embryo 18-20hr    22 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    9 larva L2    12 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    63 pupae 3d postWPP    44 pupae 4d postWPP    24 adult male 01day    24 adult male 05day    17 adult male 30day    14 adult female 01day    17 adult female 05day    10 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    24 embryo 08-10hr    23 embryo 10-12hr  (31) embryo 12-14hr  (31) embryo 14-16hr  (33) embryo 16-18hr    20 embryo 18-20hr    22 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    9 larva L2    12 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP  (63) pupae 3d postWPP  (44) pupae 4d postWPP    24 adult male 01day    24 adult male 05day    17 adult male 30day    14 adult female 01day    17 adult female 05day    10 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    24 embryo 08-10hr    23 embryo 10-12hr    31 embryo 12-14hr    31 embryo 14-16hr    33 embryo 16-18hr    20 embryo 18-20hr    22 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    9 larva L2    12 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    63 pupae 3d postWPP    44 pupae 4d postWPP    24 adult male 01day    24 adult male 05day    17 adult male 30day    14 adult female 01day    17 adult female 05day    10 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    24 embryo 08-10hr    23 embryo 10-12hr    31 embryo 12-14hr    31 embryo 14-16hr    33 embryo 16-18hr    20 embryo 18-20hr    22 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    9 larva L2    12 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    63 pupae 3d postWPP    44 pupae 4d postWPP    24 adult male 01day    24 adult male 05day    17 adult male 30day    14 adult female 01day    17 adult female 05day    10 adult female 30day    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    24 embryo 08-10hr    23 embryo 10-12hr    31 embryo 12-14hr    31 embryo 14-16hr    33 embryo 16-18hr    20 embryo 18-20hr    22 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    9 larva L2    12 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    63 pupae 3d postWPP    44 pupae 4d postWPP    24 adult male 01day    24 adult male 05day    17 adult male 30day    14 adult female 01day    17 adult female 05day    10 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    24 embryo 08-10hr    23 embryo 10-12hr  31 embryo 12-14hr  31 embryo 14-16hr  (33) embryo 16-18hr    20 embryo 18-20hr    22 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    9 larva L2    12 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP  (63) pupae 3d postWPP  (44) pupae 4d postWPP    24 adult male 01day    24 adult male 05day    17 adult male 30day    14 adult female 01day    17 adult female 05day    10 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    24 embryo 08-10hr    23 embryo 10-12hr    31 embryo 12-14hr    31 embryo 14-16hr    33 embryo 16-18hr    20 embryo 18-20hr    22 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    9 larva L2    12 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    63 pupae 3d postWPP    44 pupae 4d postWPP    24 adult male 01day    24 adult male 05day    17 adult male 30day    14 adult female 01day    17 adult female 05day    10 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12 embryo 02-04hr    8 embryo 04-06hr    15 embryo 06-08hr    24 embryo 08-10hr    23 embryo 10-12hr    31 embryo 12-14hr    31 embryo 14-16hr    33 embryo 16-18hr    20 embryo 18-20hr    22 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    9 larva L2    12 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    63 pupae 3d postWPP    44 pupae 4d postWPP    24 adult male 01day    24 adult male 05day    17 adult male 30day    14 adult female 01day    17 adult female 05day    10 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    8 embryonic GM2    12 embryonic Kc167    2 embryonic S1    11 embryonic S3    6 leg disc CME L1    5 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    5 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    8 ovary fGS/OSS    8 ovary OSC    6 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    8 embryonic GM2    12 embryonic Kc167    2 embryonic S1    11 embryonic S3    6 leg disc CME L1    5 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    5 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    8 ovary fGS/OSS    8 ovary OSC    6 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    8 embryonic GM2    12 embryonic Kc167    2 embryonic S1    11 embryonic S3    6 leg disc CME L1    5 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    5 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    8 ovary fGS/OSS    8 ovary OSC    6 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    8 embryonic GM2    12 embryonic Kc167    2 embryonic S1    11 embryonic S3    6 leg disc CME L1    5 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    5 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    8 ovary fGS/OSS    8 ovary OSC    6 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    8 embryonic GM2    12 embryonic Kc167    2 embryonic S1    11 embryonic S3    6 leg disc CME L1    5 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    5 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    8 ovary fGS/OSS    8 ovary OSC    6 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    8 embryonic GM2    12 embryonic Kc167    2 embryonic S1    11 embryonic S3    6 leg disc CME L1    5 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    5 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    8 ovary fGS/OSS    8 ovary OSC    6 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    8 embryonic GM2    12 embryonic Kc167    2 embryonic S1    11 embryonic S3    6 leg disc CME L1    5 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    5 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    8 ovary fGS/OSS    8 ovary OSC    6 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    8 embryonic GM2    12 embryonic Kc167    2 embryonic S1    11 embryonic S3    6 leg disc CME L1    5 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    5 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    8 ovary fGS/OSS    8 ovary OSC    6 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_25 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • GH15471 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026059 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31045-RE FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Mhcl Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Other Phenotypes Allele neuroanatomy defective MhcldsRNA.cIa Phenotype manifest in Allele peripheral nervous system MhcldsRNA.cIa ventral nerve cord MhcldsRNA.cIa
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Mhcl Class Mutagen Stocks Known lesion Mhclc05149 piggyBac transposase 1 -- Mhcle03696 piggyBac transposase 1 -- MhclMB08285 1 -- MhclNP1604 1 -- MhclBG00351 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mhcl Class Mutagen Stocks Known lesion MhcldsRNA.cIa in vitro construct - RNAi 0 Yes MhclGD1577 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7328 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1577} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}MhclMB08285 No P{GawB}MhclNP1604 No insertion of mobile activating element P{EPgy2}EY00454 NA miscellaneous insertions P{GT1}MhclBG00351 NA PBac{PB}Mhclc05149 NA PBac{RB}Mhcle03696 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
	There is no information supporting a biological process term for this gene. (Based on a review of available data on: 2013-03-07)
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
NOT actin-dependent ATPase activity inferred from direct assay (Guzik-Lendrum et al., 2011) actin filament binding inferred from direct assay (Guzik-Lendrum et al., 2011) NOT microfilament motor activity inferred from direct assay (Guzik-Lendrum et al., 2011)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
ATPase activity, coupled inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) ATP binding inferred from electronic annotation with InterPro:IPR001609 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
myosin complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with EMBL:D86970 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Mhcl - Ahcy89E experimental knowledge based (Guruharsha et al., 2011) Mhcl - CG11455 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mhcl - CG15343 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mhcl - l(3)j2D3 experimental knowledge based (Guruharsha et al., 2011) Mhcl - ssp anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mhcl allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67007 DroID - A comprehensive database of gene and protein interactions. • FBgn0026059 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41955 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q0KI67
Orthologs
OrthoDB Orthologs (58) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6FN52Z Dipteran inclusive ortholog search EOG63V03D Insect inclusive ortholog search EOG6JHBBQ Arthropod inclusive ortholog search EOG6GHX53 Metazoa inclusive ortholog search EOG6BGNNN
Orthologs in Drosophila Species (EOG6FN52Z)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Mhcl     Drosophila simulans   Dsim\GD20308 Y   Drosophila sechellia   Dsec\GM25733     Drosophila erecta   Dere\GG20180 Y   Drosophila yakuba   Dyak\GE26337 Y   Drosophila ananassae   Dana\GF18854 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA30222 Y   Drosophila persimilis   Dper\GL12404 Y   Drosophila willistoni   Dwil\GK14014     Drosophila virilis   Dvir\GJ23835     Drosophila mojavensis   Dmoj\GI10098     Drosophila grimshawi   Dgri\GH18838 Y
Orthologs in non-Drosophila Dipterans (EOG63V03D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Anopheles gambiae Malaria mosquito  Agam\AGAP011138   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008209
Orthologs in non-Dipteran Insects (EOG6JHBBQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB55911   Apis mellifera Western honey bee  Amel\GB55912   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014413   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14262   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14263   Atta cephalotes Leafcutter ant  Acep\ACEP18798   Atta cephalotes Leafcutter ant  Acep\ACEP18799   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13032   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13030   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17973   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17972   Linepithema humile Argentine ant  Lhum\LH14224   Linepithema humile Argentine ant  Lhum\LH14222   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19544   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19545   Solenopsis invicta Red fire ant  Sinv\SINV17853   Solenopsis invicta Red fire ant  Sinv\SINV17685   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001803   Acyrthosiphon pisum Pea aphid  Apim\ACYPI061653   Bombyx mori Silkmoth  Bmor\BGIBMGA012921   Bombyx mori Silkmoth  Bmor\BGIBMGA003509   Pediculus humanus Human body louse  Phum\PHUM607810   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15277   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15279
Orthologs in non-Insect Arthropods (EOG6GHX53)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_64163   Daphnia pulex Water flea  Dpux\JGI_V11_307123   Daphnia pulex Water flea  Dpux\JGI_V11_115745   Ixodes scapularis Deer tick  Isca\ISCW005106   Ixodes scapularis Deer tick  Isca\ISCW005108
Orthologs in non-Arthropod Metazoa (EOG6BGNNN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017270gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003598gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027930gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003881gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013488gn   Danio rerio Zebrafish  Drer\myo18ab   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000009454   Xenopus tropicalis Western clawed frog  Xtro\myo18b   Gallus gallus Domestic chicken  Ggal\MYO18B   Gallus gallus Domestic chicken  Ggal\MYO18A   Mus musculus House mouse  Mmus\Myo18b   Mus musculus House mouse  Mmus\Myo18a   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000033101   Homo sapiens Human  Hsap\ENSG00000196535   Homo sapiens Human  Hsap\MYO18B
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000196535     Hsap\MYO18B
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20308 Drosophila erecta Dere\GG20180 Drosophila yakuba Dyak\GE26337 Drosophila ananassae Dana\GF18854 Drosophila pseudoobscura pseudoobscura Dpse\GA30222 Drosophila persimilis Dper\GL12404 Drosophila willistoni Dwil\GK14016 Drosophila virilis Dvir\GJ23837 Drosophila mojavensis Dmoj\GI10100 Drosophila grimshawi Dgri\GH18838
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	26362 w1118; Mi{ET1}MhclMB08285 CG32855MB08285
Harvard	- PBac{PB}Mhclc05149 - PBac{RB}Mhcle03696
Kyoto	104044 y* w*; P{GawB}MhclNP1604 / TM6, P{UAS-lacZ.UW23-1}UW23-1
Genomic Clones ( 1 )
	BACR05C20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 102 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH15471 GH16009 LP08646
Other clones	IP18260
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05283 AT17270 AT17441 AT22728 AT23332 AT29225 GH03004 GH04935 GH22048 GM10420 LP04491 LP05315 LP08396 LP17007 RE04725 RE24936 RE30927 RE48015
Other clones	10458 16084 17221 35454 60248 67434 72921 73563 73760 73846 74585 81742 82938 118299 146175 162921 166331 175200 176070 190201 214345.4 214349.55 214409.52 214545.6 272618 272963 281568 283265 473600 523471 CK01.3B.A10 CK01.7C.B10 CK01.7D.E11 CK01.8C.H10 CK01.60C.E10 CK01.86C.E10 CK01.116A.C4 Dmel_dig_019663_0597_0726 Dmel_neb_012519_0131_3353 EK008026 EK010629 EK010818 EK048751 EK063551 EK068251 EK110357 EK110605 EK129325 EK159105 EK164905 EK168105 EK173340 EK182703 EK184629 EK197401 EK202262 EK215238 EK216629 EK237448 EK248859 EK250209 EK267153 EK271523 EK279253 EK280725 EK292331 EK299817 EK306734 EK308743 EN00327 EN03957 EP08555 EP10261 EP10362 GH20309 IP18060 IP18160 IP18360 LP09173 RP004453336
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026059 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41955
Antibody Information
	polyclonal (Guzik-Lendrum et al., 2011, Bonn et al., 2013)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Mhcl CG10224 (Misra, 2001.8.10) Source for merge of: Myosin-heavy-chain-like CG10224 (FlyBase, 1996-)
Additional comments	Annotations CG10218, CG10224 merged as CG31045 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of Myosin-heavy-chain-like CG10224 was a shared cDNA (date:010720). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) Identified with: LP08646 <up>FlyBase curator comment: EST subsequently found to be chimeric</up>. (BDGP Project Members, 2000-) FlyBase curator comment: DGC clone appears problematic: chimeric (contains Mhcl and Zeelin1 sequences). (FlyBase, 1996-)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169700 NM_169701 NM_169703 NM_170650 NM_001043250 NM_001043251 NM_001202304 NM_001275694 RefSeq (Proteins) • NP_732108 NP_732109 NP_732110 NP_732111 NP_001036715 NP_001036716 NP_001189233 NP_001262623 DDBJ / EMBL / GenBank • AA803221 AAF55271 AAF55271.2 AAK92927 AAL87864 AAN13694.1 AAN13695 AAN13695.1 AAN13696 AAN13696.1 AAN13697 AAN13697.1 AAN71183 ABI31171 ABI31172 ADV37324 AF454347 AGB96003 AI061870 AI064490 AI260573 AI292545 AI292965 AJ132656 AW940592 AW944098 AY051503 BT001428 CAA10724 CZ469761 CZ469762 CZ481454 Entrez Gene - A searchable database of RefSeq genes. • 41955 UniProtKB/TrEMBL • O96816 Q0KI66 Q0KI67 Q7K523 Q8IH49 Q8INC1 Q8INC3 Q8T6M0 Q9VEZ0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • IQ motif, EF-hand binding site (IPR000048) PDZ domain (IPR001478) Myosin head, motor domain (IPR001609) Myosin-like IQ motif-containing domain (IPR027401) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Myosin tail (IPR002928) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH15471
Linkouts
	BioGRID - A database of protein and genetic interactions • 67007 DroID - A comprehensive database of gene and protein interactions. • FBgn0026059 DRSC - Results from RNAi screens. • FBgn0026059 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026059 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31045-RE FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026059 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41955 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41955 modMine - Data generated by the modENCODE project. • FBgn0026059 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q0KI67
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG10218 (Berg et al., 2001, Goldstein and Gunawardena, 2000, Rogers et al., 2003) CG10224 (Misra, 2001.8.10, ) CG31045 (Guzik-Lendrum et al., 2011) DmPDZ (Yamashita et al., 2000) Mhcl (Levis et al., 2011.12.16, Wasbrough et al., 2010, Guzik-Lendrum et al., 2011) MHCL(PDZ) (Yamashita et al., 2000)
Name Synonym	myosin 18 (Guzik-Lendrum et al., 2011) myosin heavy chain (Biru, 1999.1.28) Myosin heavy chain-like (Yamashita et al., 2000) Myosin-heavy-chain-like   Myosin XVIII (Rogers et al., 2003) myosin XVIII (PDZ) (Rogers et al., 2003) PDZ-myosin (Berg et al., 2001, Rogers et al., 2003)
Secondary FlyBase IDs
	FBgn0038399 FBgn0051045
References ( 37 )
Generate a list of	All references relating to this gene ( 37 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 11 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 5 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 3 )
Recent research papers ( 2 )
	Bonn et al., 2013, Exp. Cell Res. 319(4): 402--416 Myosin heavy chain-like localizes at cell contact sites during Drosophila myoblast fusion and interacts in vitro with Rolling pebbles 7. [FBrf0220706] Guzik-Lendrum et al., 2011, J. Biol. Chem. 286(24): 21755--21766 Drosophila melanogaster Myosin-18 Represents a Highly Divergent Motor with Actin Tethering Properties. [FBrf0213876] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...