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Gene Dmel\Tip60

General Information
Symbol	Dmel\Tip60	Species	D. melanogaster
Name	Tip60	Annotation symbol	CG6121
Feature type	protein_coding_gene	FlyBase ID	FBgn0026080
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	dTip60, EG0007.7, Dmel/TIP60
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	4A6-4B1	Sequence location	X:4,008,833..4,011,520 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Tip60 is referred to in FlyBase by the symbol Dmel\Tip60 (CG6121, FBgn0026080). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: histone acetyltransferase activity. There is experimental evidence that it is involved in the biological process: regulation of terminal button organization; regulation of synaptic plasticity; response to DNA damage stimulus; nervous system development; histone H4 acetylation; histone exchange; histone acetylation. 17 alleles are reported. The phenotypes of these alleles are annotated with: wing disc; trichogen cell; terminal bouton; wing; type Is terminal bouton. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Acyl-CoA N-acyltransferase; Chromo domain-like; Chromo domain/shadow; MOZ/SAS-like protein; RNA binding activity-knot of a chromodomain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, adult salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1635824_at partially aligns to an exonic region of the only FlyBase-annotated transcript isoform of Tip60: 12 out of 13 probes fall into this exonic region. Gene sequence location is X:4008833..4011520.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms nervous system development histone H4 acetylation
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 4A6-4B1   Limits computationally determined from genome sequence between P{EP}CG2930EP1352 and P{EP}EP425
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tip60 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Stop Codon spans the intron.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tip60-RA FBtr0070668  NM_131923   2390   541 Tip60-RB FBtr0333185  NM_001272304   2368   473 Tip60-RC FBtr0333186  NM_001272305   1852   541
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tip60-PA   FBpp0070636   61.2   541   8.77     NP_572151   AAF45923 Tip60-PB   FBpp0305387   53.0   473   8.39     NP_001259233   AGB95079 Tip60-PC   FBpp0305388   61.2   541   8.77     NP_001259234   AGB95080
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Chromo domain/shadow (IPR000953) MOZ/SAS-like protein (IPR002717) Acyl-CoA N-acyltransferase (IPR016181) Chromo domain-like (IPR016197) RNA binding activity-knot of a chromodomain (IPR025995)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698545   AA950901   AE014298 AAF45923   AE014298 AGB95079   AE014298 AGB95080   AL033125 CAA21829   AW943063   AY051795 AAK93219   BI356219   BI366320   BI366658   BI375849   BI484606   BI580600   BX013979   CK131687   CO177109   CZ480215   CZ480216   EC241516   EV583433   GH754984   GH755254   GH771757   GH772533   GH773534   GH782187   GH782643   GH786687   GH789592   GH802583   GH809604   GH813450   GH816699   GH817085   GH818242   GH819384   GH822107   GH831943   GH842140   GH843348   GH848418   GH852469   GH852851   GH860367   GH860941   GH866714   GH876394   GH882700   GH883352   GH892893   GH897138   GH905803   GH909671   GH918503   GH928147   GH935088   GH936968   GH939493
UniProtKB/Swiss-Prot	Q960X4
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
histone acetyltransferase complex inferred from physical interaction with pont (Kusch et al., 2004) nucleus inferred from direct assay (Schirling et al., 2010, Kusch et al., 2004) polytene chromosome interband inferred from direct assay (Schirling et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, adult salivary gland, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    133.85 Larval Midgut    70 Larval Hindgut    67.2 Larval Malpighian Tubules    122.8 Larval Fat Body    68.1 Larval Salivary Gland    87.9 Larval Trachea    77.775 Larval Carcass    93.1 Adult Head    72.8 Adult Eye    77.375 Adult Brain    138.5 Adult Thoracic-Abdominal Ganglion    112.8 Adult Crop    99.3 Adult Midgut    74.9 Adult Hindgut    83 Adult Malpighian Tubules    77.8 Adult Fat Body    42.7 Adult Salivary Gland    123.4 Adult Heart    47.6 Adult VirginFemale Spermatheca    57.4 Adult InseminatedFemale Spermatheca    54.5 Adult Ovary    230.5 Adult Testis    34.3 Adult Male Accessory Gland    62.4 Adult Carcass    59.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    133.85 Larval Midgut    70 Larval Hindgut    67.2 Larval Malpighian Tubules    122.8 Larval Fat Body    68.1 Larval Salivary Gland    87.9 Larval Trachea    77.775 Larval Carcass    93.1 Adult Head    72.8 Adult Eye    77.375 Adult Brain    138.5 Adult Thoracic-Abdominal Ganglion    112.8 Adult Crop    99.3 Adult Midgut    74.9 Adult Hindgut    83 Adult Malpighian Tubules    77.8 Adult Fat Body    42.7 Adult Salivary Gland    123.4 Adult Heart    47.6 Adult VirginFemale Spermatheca    57.4 Adult InseminatedFemale Spermatheca    54.5 Adult Ovary    230.5 Adult Testis    34.3 Adult Male Accessory Gland    62.4 Adult Carcass    59.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    133.85 Larval Midgut    70 Larval Hindgut    67.2 Larval Malpighian Tubules    122.8 Larval Fat Body    68.1 Larval Salivary Gland    87.9 Larval Trachea    77.775 Larval Carcass    93.1 Adult Head    72.8 Adult Eye    77.375 Adult Brain    138.5 Adult Thoracic-Abdominal Ganglion    112.8 Adult Crop    99.3 Adult Midgut    74.9 Adult Hindgut    83 Adult Malpighian Tubules    77.8 Adult Fat Body    42.7 Adult Salivary Gland    123.4 Adult Heart    47.6 Adult VirginFemale Spermatheca    57.4 Adult InseminatedFemale Spermatheca    54.5 Adult Ovary    230.5 Adult Testis    34.3 Adult Male Accessory Gland    62.4 Adult Carcass    59.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    133.85 Larval Midgut    70 Larval Hindgut    67.2 Larval Malpighian Tubules    122.8 Larval Fat Body    68.1 Larval Salivary Gland    87.9 Larval Trachea    77.775 Larval Carcass    93.1 Adult Head    72.8 Adult Eye    77.375 Adult Brain    138.5 Adult Thoracic-Abdominal Ganglion    112.8 Adult Crop    99.3 Adult Midgut    74.9 Adult Hindgut    83 Adult Malpighian Tubules    77.8 Adult Fat Body    42.7 Adult Salivary Gland    123.4 Adult Heart    47.6 Adult VirginFemale Spermatheca    57.4 Adult InseminatedFemale Spermatheca    54.5 Adult Ovary    230.5 Adult Testis    34.3 Adult Male Accessory Gland    62.4 Adult Carcass    59.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    133.85 Larval Midgut    70 Larval Hindgut    67.2 Larval Malpighian Tubules    122.8 Larval Fat Body    68.1 Larval Salivary Gland    87.9 Larval Trachea    77.775 Larval Carcass    93.1 Adult Head    72.8 Adult Eye    77.375 Adult Brain    138.5 Adult Thoracic-Abdominal Ganglion    112.8 Adult Crop    99.3 Adult Midgut    74.9 Adult Hindgut    83 Adult Malpighian Tubules    77.8 Adult Fat Body    42.7 Adult Salivary Gland    123.4 Adult Heart    47.6 Adult VirginFemale Spermatheca    57.4 Adult InseminatedFemale Spermatheca    54.5 Adult Ovary    230.5 Adult Testis    34.3 Adult Male Accessory Gland    62.4 Adult Carcass    59.8 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    133.85 Larval Midgut    70 Larval Hindgut    67.2 Larval Malpighian Tubules    122.8 Larval Fat Body    68.1 Larval Salivary Gland    87.9 Larval Trachea    77.775 Larval Carcass    93.1 Adult Head    72.8 Adult Eye    77.375 Adult Brain    138.5 Adult Thoracic-Abdominal Ganglion    112.8 Adult Crop    99.3 Adult Midgut    74.9 Adult Hindgut    83 Adult Malpighian Tubules    77.8 Adult Fat Body    42.7 Adult Salivary Gland    123.4 Adult Heart    47.6 Adult VirginFemale Spermatheca    57.4 Adult InseminatedFemale Spermatheca    54.5 Adult Ovary    230.5 Adult Testis    34.3 Adult Male Accessory Gland    62.4 Adult Carcass    59.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    133.85 Larval Midgut    70 Larval Hindgut    67.2 Larval Malpighian Tubules    122.8 Larval Fat Body    68.1 Larval Salivary Gland    87.9 Larval Trachea    77.775 Larval Carcass    93.1 Adult Head    72.8 Adult Eye    77.375 Adult Brain    138.5 Adult Thoracic-Abdominal Ganglion    112.8 Adult Crop    99.3 Adult Midgut    74.9 Adult Hindgut    83 Adult Malpighian Tubules    77.8 Adult Fat Body    42.7 Adult Salivary Gland    123.4 Adult Heart    47.6 Adult VirginFemale Spermatheca    57.4 Adult InseminatedFemale Spermatheca    54.5 Adult Ovary    230.5 Adult Testis    34.3 Adult Male Accessory Gland    62.4 Adult Carcass    59.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    133.85 Larval Midgut    70 Larval Hindgut    67.2 Larval Malpighian Tubules    122.8 Larval Fat Body    68.1 Larval Salivary Gland    87.9 Larval Trachea    77.775 Larval Carcass    93.1 Adult Head    72.8 Adult Eye    77.375 Adult Brain    138.5 Adult Thoracic-Abdominal Ganglion    112.8 Adult Crop    99.3 Adult Midgut    74.9 Adult Hindgut    83 Adult Malpighian Tubules    77.8 Adult Fat Body    42.7 Adult Salivary Gland    123.4 Adult Heart    47.6 Adult VirginFemale Spermatheca    57.4 Adult InseminatedFemale Spermatheca    54.5 Adult Ovary    230.5 Adult Testis    34.3 Adult Male Accessory Gland    62.4 Adult Carcass    59.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    72.8   NA  Eye    77.375   NA  Brain    138.5   133.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    112.8   NA  Crop    99.3   70  Midgut    74.9   67.2  Hindgut    83   122.8  Malpighian Tubules    77.8   68.1  Fat Body    42.7   87.9  Salivary Gland    123.4   NA  Heart    47.6   77.775  Trachea    NA   NA  VirginFemale Spermatheca    57.4   NA  InseminatedFemale Spermatheca    54.5   NA  Ovary    230.5   NA  Testis    34.3   NA  Male Accessory Gland    62.4   93.1  Carcass    59.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    6 ovary, virgin 4-day female    26 ovary, mated 4-day female    20 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    6 ovary, virgin 4-day female  26 ovary, mated 4-day female    20 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    6 ovary, virgin 4-day female    26 ovary, mated 4-day female    20 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    6 ovary, virgin 4-day female    26 ovary, mated 4-day female    20 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    6 ovary, virgin 4-day female    26 ovary, mated 4-day female    20 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    6 ovary, virgin 4-day female  26 ovary, mated 4-day female    20 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    6 ovary, virgin 4-day female    26 ovary, mated 4-day female    20 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    10 central nervous system, pupae P8    6 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    6 ovary, virgin 4-day female    26 ovary, mated 4-day female    20 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    41 embryo 04-06hr    35 embryo 06-08hr    32 embryo 08-10hr    31 embryo 10-12hr    23 embryo 12-14hr    19 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    22 larva L1    9 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    14 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    7 pupae 4d postWPP    8 adult male 01day    8 adult male 05day    9 adult male 30day    10 adult female 01day    15 adult female 05day    21 adult female 30day    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (46) embryo 02-04hr  (41) embryo 04-06hr  (35) embryo 06-08hr  (32) embryo 08-10hr  (31) embryo 10-12hr    23 embryo 12-14hr    19 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    22 larva L1    9 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    14 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    7 pupae 4d postWPP    8 adult male 01day    8 adult male 05day    9 adult male 30day    10 adult female 01day    15 adult female 05day    21 adult female 30day    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    41 embryo 04-06hr    35 embryo 06-08hr    32 embryo 08-10hr    31 embryo 10-12hr    23 embryo 12-14hr    19 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    22 larva L1    9 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    14 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    7 pupae 4d postWPP    8 adult male 01day    8 adult male 05day    9 adult male 30day    10 adult female 01day    15 adult female 05day    21 adult female 30day    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    41 embryo 04-06hr    35 embryo 06-08hr    32 embryo 08-10hr    31 embryo 10-12hr    23 embryo 12-14hr    19 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    22 larva L1    9 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    14 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    7 pupae 4d postWPP    8 adult male 01day    8 adult male 05day    9 adult male 30day    10 adult female 01day    15 adult female 05day    21 adult female 30day    22 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    41 embryo 04-06hr    35 embryo 06-08hr    32 embryo 08-10hr    31 embryo 10-12hr    23 embryo 12-14hr    19 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    22 larva L1    9 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    14 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    7 pupae 4d postWPP    8 adult male 01day    8 adult male 05day    9 adult male 30day    10 adult female 01day    15 adult female 05day    21 adult female 30day    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (46) embryo 02-04hr  (41) embryo 04-06hr  (35) embryo 06-08hr  32 embryo 08-10hr  31 embryo 10-12hr    23 embryo 12-14hr    19 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    22 larva L1    9 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    14 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    7 pupae 4d postWPP    8 adult male 01day    8 adult male 05day    9 adult male 30day    10 adult female 01day    15 adult female 05day    21 adult female 30day    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    41 embryo 04-06hr    35 embryo 06-08hr    32 embryo 08-10hr    31 embryo 10-12hr    23 embryo 12-14hr    19 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    22 larva L1    9 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    14 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    7 pupae 4d postWPP    8 adult male 01day    8 adult male 05day    9 adult male 30day    10 adult female 01day    15 adult female 05day    21 adult female 30day    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    41 embryo 04-06hr    35 embryo 06-08hr    32 embryo 08-10hr    31 embryo 10-12hr    23 embryo 12-14hr    19 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    22 larva L1    9 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    14 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    7 pupae 4d postWPP    8 adult male 01day    8 adult male 05day    9 adult male 30day    10 adult female 01day    15 adult female 05day    21 adult female 30day    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    8 embryonic 1182-4H    16 embryonic GM2    7 embryonic Kc167    19 embryonic S1    16 embryonic S3    6 leg disc CME L1    10 wing disc CME-W2    9 wing disc ML-DmD8    7 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    7 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (71) Schneider line 2 Sg4    8 embryonic 1182-4H    16 embryonic GM2    7 embryonic Kc167    19 embryonic S1    16 embryonic S3    6 leg disc CME L1    10 wing disc CME-W2    9 wing disc ML-DmD8    7 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    7 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    8 embryonic 1182-4H    16 embryonic GM2    7 embryonic Kc167    19 embryonic S1    16 embryonic S3    6 leg disc CME L1    10 wing disc CME-W2    9 wing disc ML-DmD8    7 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    7 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    8 embryonic 1182-4H    16 embryonic GM2    7 embryonic Kc167    19 embryonic S1    16 embryonic S3    6 leg disc CME L1    10 wing disc CME-W2    9 wing disc ML-DmD8    7 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    7 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    8 embryonic 1182-4H    16 embryonic GM2    7 embryonic Kc167    19 embryonic S1    16 embryonic S3    6 leg disc CME L1    10 wing disc CME-W2    9 wing disc ML-DmD8    7 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    7 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (71) Schneider line 2 Sg4    8 embryonic 1182-4H    16 embryonic GM2    7 embryonic Kc167    19 embryonic S1    16 embryonic S3    6 leg disc CME L1    10 wing disc CME-W2    9 wing disc ML-DmD8    7 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    7 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    8 embryonic 1182-4H    16 embryonic GM2    7 embryonic Kc167    19 embryonic S1    16 embryonic S3    6 leg disc CME L1    10 wing disc CME-W2    9 wing disc ML-DmD8    7 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    7 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    8 embryonic 1182-4H    16 embryonic GM2    7 embryonic Kc167    19 embryonic S1    16 embryonic S3    6 leg disc CME L1    10 wing disc CME-W2    9 wing disc ML-DmD8    7 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    7 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026080 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6121-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal Tip60dsRNA.Z.Act5C lethal, with Scer\GAL4337Y Tip60dsRNA.Z.Scer\UAS lethal, with Scer\GAL4da.G32 Tip60Scer\UAS.Scer\UAS.cSa lethal | heat sensitive, with Scer\GAL4T80 Tip60Scer\UAS.Scer\UAS.cSa lethal | partially, with Scer\GAL4how-24B Tip60dsRNA.Z.Scer\UAS lethal | pupal stage, with Scer\GAL4337Y Tip60E431Q.Scer\UAS lethal | pupal stage, with Scer\GAL4Act5C.PI Tip60dsRNA.Z.Scer\UAS Tip60E431Q.Scer\UAS lethal | pupal stage, with Scer\GAL4elav-C155 Tip60dsRNA.Z.Scer\UAS Tip60E431Q.Scer\UAS lethal | pupal stage, with Scer\GAL4Mef2.247 Tip60dsRNA.Z.Scer\UAS Tip60E431Q.Scer\UAS lethal | pupal stage, with Scer\GAL4pnr-MD237 Tip60GD11826 partially lethal - majority die, with Scer\GAL460IIA Tip60E431Q.Scer\UAS partially lethal - majority die, with Scer\GAL4179Y Tip60E431Q.Scer\UAS partially lethal - majority die, with Scer\GAL4elav.PLu Tip60E431Q.Scer\UAS partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Tip60GD11826 viable Tip60e02395 viable, with Scer\GAL4337Y Tip60Scer\UAS.cLa viable, with Scer\GAL4Act5C.PI Tip60Scer\UAS.cLa Tip60s-s.Scer\UAS viable, with Scer\GAL4en-e16E Tip60Scer\UAS.Scer\UAS.cSa Sterility Allele fertile Tip60e02395 Other Phenotypes Allele cytokinesis defective Tip60dsRNA.Z.Act5C increased cell death, with Scer\GAL4en-e16E Tip60Scer\UAS.Scer\UAS.cSa neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 Tip60dsRNA.Z.Scer\UAS Tip60E431Q.Scer\UAS neuroanatomy defective | larval stage, with Scer\GAL4Mef2.247 Tip60dsRNA.Z.Scer\UAS Tip60E431Q.Scer\UAS visible, with Scer\GAL4en-e16E Tip60Scer\UAS.Scer\UAS.cSa visible, with Scer\GAL4pnr-MD237 Tip60GD11826 visible, with Scer\GAL4T80 Tip60Scer\UAS.Scer\UAS.cSa Phenotype manifest in Allele terminal bouton, with Scer\GAL4elav-C155 Tip60dsRNA.Z.Scer\UAS Tip60E431Q.Scer\UAS terminal bouton, with Scer\GAL4Mef2.247 Tip60dsRNA.Z.Scer\UAS Tip60E431Q.Scer\UAS trichogen cell, with Scer\GAL4pnr-MD237 Tip60GD11826 type I bouton | ectopic, with Scer\GAL4elav-C155 Tip60dsRNA.Z.Scer\UAS Tip60E431Q.Scer\UAS type I bouton | ectopic, with Scer\GAL4Mef2.247 Tip60dsRNA.Z.Scer\UAS Tip60E431Q.Scer\UAS type Ib terminal bouton | ectopic, with Scer\GAL4elav-C155 Tip60dsRNA.Z.Scer\UAS Tip60E431Q.Scer\UAS type Ib terminal bouton | ectopic, with Scer\GAL4Mef2.247 Tip60dsRNA.Z.Scer\UAS Tip60E431Q.Scer\UAS type Is terminal bouton, with Scer\GAL4Mef2.247 Tip60dsRNA.Z.Scer\UAS Tip60E431Q.Scer\UAS wing, with Scer\GAL4en-e16E Tip60Scer\UAS.Scer\UAS.cSa wing, with Scer\GAL4T80 Tip60Scer\UAS.Scer\UAS.cSa wing disc, with Scer\GAL4en-e16E Tip60Scer\UAS.Scer\UAS.cSa wing vein | ectopic, with Scer\GAL4en-e16E Tip60Scer\UAS.Scer\UAS.cSa wing vein | ectopic, with Scer\GAL4T80 Tip60Scer\UAS.Scer\UAS.cSa
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Tip60 Class Mutagen Stocks Known lesion Tip60e02395 piggyBac transposase 2 -- Tip60GG01739 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tip60 Class Mutagen Stocks Known lesion Tip60GD11826 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Tip60GL00130 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tip60HM05049 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tip60dsRNA.cKa in vitro construct - RNAi 0 Yes Tip60dsRNA.Z.Act5C in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Tip60dsRNA.Z.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Tip60E431Q.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes Tip60KK107642 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Tip60MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Tip60NIG.6121R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Tip60s-s.Act5C in vitro construct - regulatory fusion 0 Yes Tip60s-s.Scer\UAS in vitro construct - regulatory fusion 0 Yes Tip60Scer\UAS.cLa in vitro construct - regulatory fusion 0 Yes Tip60Scer\UAS.cSa in vitro construct - regulatory fusion 0 Yes Tip60Scer\UAS.Scer\UAS.cSa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11826} NA P{KK107642} NA P{NIG.6121R} NA P{TRiP.GL00130} NA P{TRiP.HM05049} NA P{UAS-Tip60.E431Q} NA P{UAS-Tip60.L} NA P{UAS-Tip60.RNAi.S} NA P{UAS-Tip60.RNAi.Z} NA P{UAS-Tip60.S} NA P{UAS-Tip60.s-s} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Tip60e02395 NA insertion of mobile activating element P{Mae-UAS.6.11}Tip60GG01739 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
histone acetyltransferase activity inferred from mutant phenotype (Lorbeck et al., 2011)
Biological Process
CV term Evidence References
histone acetylation inferred from direct assay (Kusch et al., 2004) histone exchange inferred from direct assay (Kusch et al., 2004) histone H4 acetylation inferred from mutant phenotype (Lorbeck et al., 2011) nervous system development inferred from mutant phenotype (Lorbeck et al., 2011) regulation of synaptic plasticity inferred from direct assay (Sarthi and Elefant, 2011) regulation of terminal button organization inferred from direct assay (Sarthi and Elefant, 2011) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009)
Cellular Component
CV term Evidence References
histone acetyltransferase complex inferred from physical interaction with pont (Kusch et al., 2004) nucleus inferred from direct assay (Schirling et al., 2010, Kusch et al., 2004) polytene chromosome interband inferred from direct assay (Schirling et al., 2010)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
histone acetyltransferase activity inferred from sequence or structural similarity with Saccharomyces ESA1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR002717 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Tip60 - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - Bap55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - CG12264 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - CG18178 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - CG34417 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - CG8677 anti bait coimmunoprecipitation, western blot (Hanai et al., 2008) Tip60 - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - RpS11 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - homer anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - shot anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tip60 - vig anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tip60 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57879 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026080 DroID - A comprehensive database of gene and protein interactions. • FBgn0026080 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31362
Orthologs
OrthoDB Orthologs (69) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6K6GQ1 Dipteran inclusive ortholog search EOG6W0XNJ Insect inclusive ortholog search EOG6N2ZJ8 Arthropod inclusive ortholog search EOG6H44K2 Metazoa inclusive ortholog search EOG6MH511
Orthologs in Drosophila Species (EOG6K6GQ1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Tip60     Drosophila simulans   Dsim\EG:EG0007.7 Y   Drosophila sechellia   Dsec\GM12702 Y   Drosophila erecta   Dere\EG:EG0007.7 Y   Drosophila yakuba   Dyak\EG:EG0007.7 Y   Drosophila ananassae   Dana\GF21492 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA25056     Drosophila pseudoobscura pseudoobscura   Dpse\GA19369 Y   Drosophila persimilis   Dper\GL21384     Drosophila persimilis   Dper\GL14311     Drosophila persimilis   Dper\GL18118     Drosophila willistoni   Dwil\GK17633 Y   Drosophila virilis   Dvir\GJ16425 Y   Drosophila virilis   Dvir\GJ13223     Drosophila mojavensis   Dmoj\GI20630     Drosophila mojavensis   Dmoj\GI16149 Y   Drosophila grimshawi   Dgri\GH24817 Y
Orthologs in non-Drosophila Dipterans (EOG6W0XNJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014072   Anopheles gambiae Malaria mosquito  Agam\AGAP001539   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001206
Orthologs in non-Dipteran Insects (EOG6N2ZJ8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Tip60   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000377   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18519   Atta cephalotes Leafcutter ant  Acep\ACEP10317   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21081   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22112   Linepithema humile Argentine ant  Lhum\LH22423   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22928   Solenopsis invicta Red fire ant  Sinv\SINV13821   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007943   Bombyx mori Silkmoth  Bmor\BGIBMGA008516   Pediculus humanus Human body louse  Phum\PHUM229890   Tribolium castaneum Red flour beetle  Tcas\GLEAN_08142
Orthologs in non-Insect Arthropods (EOG6H44K2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW020584
Orthologs in non-Arthropod Metazoa (EOG6MH511)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mys-2 Y Caenorhabditis elegans Nematode  Cele\mys-1 Y Caenorhabditis elegans Nematode  Cele\lsy-12 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028153gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027785gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008304gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023102gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017172gn Y Danio rerio Zebrafish  Drer\si:dkey-24f15.3 Y Danio rerio Zebrafish  Drer\myst3 Y Danio rerio Zebrafish  Drer\htatip Y Danio rerio Zebrafish  Drer\zgc:92510 Y Danio rerio Zebrafish  Drer\myst2 Y Danio rerio Zebrafish  Drer\ENSDARG00000027187 Y Danio rerio Zebrafish  Drer\zgc:154037 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000021908 Y Xenopus tropicalis Western clawed frog  Xtro\kat5 Y Xenopus tropicalis Western clawed frog  Xtro\kat8 Y Gallus gallus Domestic chicken  Ggal\MYST2 Y Gallus gallus Domestic chicken  Ggal\MYST4 Y Gallus gallus Domestic chicken  Ggal\KAT6A Y Mus musculus House mouse  Mmus\Kat6b Y Mus musculus House mouse  Mmus\Myst2 Y Mus musculus House mouse  Mmus\Kat5 Y Mus musculus House mouse  Mmus\Myst3 Y Mus musculus House mouse  Mmus\Kat8 Y Rattus norvegicus Norway rat  Rnor\Kat7 Y Rattus norvegicus Norway rat  Rnor\RGD1566399 Y Rattus norvegicus Norway rat  Rnor\Kat6a Y Rattus norvegicus Norway rat  Rnor\Kat8 Y Rattus norvegicus Norway rat  Rnor\Kat5 Y Homo sapiens Human  Hsap\ENSG00000172977 Y Homo sapiens Human  Hsap\KAT6A Y Homo sapiens Human  Hsap\KAT7 Y Homo sapiens Human  Hsap\ENSG00000156650 Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\ENSG00000172977     Hsap\KAT6A     Hsap\KAT7     Hsap\ENSG00000156650
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\EG:EG0007.7 Drosophila sechellia Dsec\GM12702 Drosophila erecta Dere\EG:EG0007.7 Drosophila yakuba Dyak\EG:EG0007.7 Drosophila ananassae Dana\GF21492 Drosophila pseudoobscura pseudoobscura Dpse\GA19369 Drosophila willistoni Dwil\GK17633 Drosophila virilis Dvir\GJ16425 Drosophila mojavensis Dmoj\GI16149 Drosophila grimshawi Dgri\GH24817
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	18052 w1118 PBac{RB}Tip60e02395 28563 y1 v1; P{TRiP.HM05049}attP2 35243 y1 sc* v1; P{TRiP.GL00130}attP2 15630 y1 w67c23 P{Mae-UAS.6.11}Tip60GG01739
Harvard	- PBac{RB}Tip60e02395
VDRC	v22233 w1118 P{GD11826}v22233 v22231 w1118; P{GD11826}v22231
Genomic Clones ( 1 )
	BACR21I10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 51 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD31064
Other clones	DPiM_LD31064
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL04902 LP12663 RE42316 RE52244 RE63741 RE67735 RE74816
Other clones	CK01.66C.E7 Dmel_dig_020325_0700_3181 EK052520 RE51831 RP003017038 RP003033902 RP003053304 RP003071944 RP003080665 RP003103518 RP003108369 RP003126721 RP003136497 RP003145919 RP003157506 RP003179139 RP003185732 RP003200408 RP003207355 RP003212343 RP003217553 RP003219504 RP003253996 RP003268712 RP003319142 RP003330128 RP003340090 RP003381246 RP003415874 RP003418129 RP003449357 RP003455961 RP003479171 RP003526537 RP003560498 RP003564057 RP003580130 RP003616469 RP003631755 RP003648463 RP003664130 RP003675739
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026080 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31362
Antibody Information
	polyclonal (Pirooznia et al., 2012, Schirling et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: EG:EG0007.7 CG6121 (Zhao, 1999.11) Source for identity of: Tip60 CG6121 (Kusch et al., 2004)
Source for database merge of
Additional comments
Other Comments
	Tip60 controls neuronal specific gene expression profiles that are required for appropriate development and function of the nervous system. (Lorbeck et al., 2011) DNA-protein interactions: genome-wide binding profile assayed for Tip60 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes. (Agaisse et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_131923 NM_001272304 NM_001272305 RefSeq (Proteins) • NP_572151 NP_001259233 NP_001259234 DDBJ / EMBL / GenBank • AA950901 AAF45923 AAK93219 AGB95079 AGB95080 AL033125 AW943063 AY051795 CAA21829 CZ480215 CZ480216 Entrez Gene - A searchable database of RefSeq genes. • 31362 UniProtKB/Swiss-Prot • Q960X4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Chromo domain/shadow (IPR000953) MOZ/SAS-like protein (IPR002717) Acyl-CoA N-acyltransferase (IPR016181) Chromo domain-like (IPR016197) RNA binding activity-knot of a chromodomain (IPR025995)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57879 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026080 DroID - A comprehensive database of gene and protein interactions. • FBgn0026080 DRSC - Results from RNAi screens. • FBgn0026080 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026080 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6121-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026080 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31362 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31362 modMine - Data generated by the modENCODE project. • FBgn0026080
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	6121 (Ravi et al., 2009) CG6121 (Yang, 2004, Agaisse et al., 2005, Kusch et al., 2004, de la Cruz et al., 2005, Brody et al., 2002, Zhu et al., 2007, Perkins et al., 2009, Chen et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) DmEG0007.7 (Pannuti and Lucchesi, 2000) Dmel/TIP60 (Toth and Elefant, 2007, Zhu and Elefant, 2007) Dmel\TIP60 (Zhu et al., 2007) dmHAG405 (Pandey et al., 2002) dTip60 (Agaisse et al., 2005, Kusch et al., 2004, Kusch et al., 2004, Jin, 2005, Kaeser and Emerson, 2006, Lorbeck et al., 2011, Hanai et al., 2008) dTIP60 (Qi et al., 2006, Sarthi and Elefant, 2011) EG0007.7 (Sanjuan and Marin, 2001, Pilot et al., 2006) EG:EG0007.7 (Giot et al., 2003, ) Tip60 (Jin, 2005, FlyBase Curators, 2008, Chen et al., 2008, Mourikis et al., 2010, Schirling et al., 2010, Schiemann et al., 2010, Lorbeck et al., 2011, Japanese National Institute of Genetics, 2012.5.21) TIP60 (Filion et al., 2010)
Name Synonym	Tat-interactive protein (Kaeser and Emerson, 2006) Tat-interactive protein-60 KDa (Lorbeck et al., 2011) Tip60
Secondary FlyBase IDs
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 5 ) Review  ( 7 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 3 )
Recent research papers ( 4 )
	Petesch and Lis, 2012, Mol. Cell 45(1): 64--74 Activator-Induced Spread of Poly(ADP-Ribose) Polymerase Promotes Nucleosome Loss at Hsp70. [FBrf0217198] Pirooznia et al., 2012, Genetics 192(4): 1327--1345 Epigenetic regulation of axonal growth of Drosophila pacemaker cells by histone acetyltransferase tip60 controls sleep. [FBrf0220123] Lorbeck et al., 2011, PLoS ONE 6(4): e18412 Microarray analysis uncovers a role for tip60 in nervous system function and general metabolism. [FBrf0213446] Sarthi and Elefant, 2011, PLoS ONE 6(10): e26202 dTip60 HAT Activity Controls Synaptic Bouton Expansion at the Drosophila Neuromuscular Junction. [FBrf0216592] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...