dTip60, Dmel/TIP60, EG0007.7, EG:EG0007.7
histone acetyltransferase that regulates general metabolism, axon growth and dendritic targeting and sleep-wake cycle - regulates acetylation of histone H2A and promotes the generation of silent chromatin
Stop Codon spans the intron.
Gene model reviewed during 5.46
Component of the Tip60 chromatin-remodeling complex which contains the catalytic subunit Tip60 and the subunits Domino, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1.
Autoacetylation at Lys-355 is required for proper function.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tip60 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Tip60 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Tip60 controls neuronal specific gene expression profiles that are required for appropriate development and function of the nervous system.
DNA-protein interactions: genome-wide binding profile assayed for Tip60 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).