dADAR, EG:BACN35H14.1 , hypnos-2
Gene model reviewed during 5.49
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Shares 5' UTR with downstream gene.
Gene model reviewed during 5.41
Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
Gene model reviewed during 5.55
Gene model reviewed during 6.32
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Adar using the Feature Mapper tool.
3'-RACE identified long and short isoforms of Adar produced during embryogenesis. The longer isoform(s) was present throughout embryogenesis, with the short isoform(s) being expressed from stage 10 onwards. There was minimal expression of Adar seen in larvae or adults.
Adar transcript is expressed throughout embryogenesis, with highest expression levels observed at 0-2 hours AEL and 8-12 hrs AEL. Expression levels are low during larval development, and the short isoforms exhibit another small peak during pupal stages. In situ analysis reveals that the short transcript isoforms are expressed primarily in pre-cellular stages, and in the gut endothelium from embryonic stage 16, in contrast to the more widespread pattern observed for the longer transcript isoforms.
Adar protein localizes to the nucleus, and is more concentrated in the nucleolus relative to the diffuse expression in the rest of the nucleus.
Adar long protein isoforms are expressed at all embryonic stages, at low levels during the third larval instar and early pupal stages, and higher levels in late pupal stages and in adult heads. The Adar short protein isoforms can be detected by Western blot only at the 0-2 and 12-16 hour AEL timepoints.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Adar in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Adults lacking Adar function are morphologically wild type, but show extreme behavioural deficits, including temperature-sensitive paralysis, locomotor uncoordination and tremors which increase in severity with age. Neurodegeneration accompanies the increase in phenotypic severity.
Adar undergoes developmentally regulated RNA editing that changes a conserved residue in the catalytic domain.
The genetic basis of anoxia tolerance is studied. 'hypnos' is the personification of sleep in Greek mythology.