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Gene Dmel\CDC45L

General Information
Symbol	Dmel\CDC45L	Species	D. melanogaster
Name	CDC45L	Annotation symbol	CG3658
Feature type	protein_coding_gene	FlyBase ID	FBgn0026143
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	CDC45, EG:BACR7A4.11
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	1E1-1E1	Sequence location	X:922,324..924,614 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene CDC45L is referred to in FlyBase by the symbol Dmel\CDC45L (CG3658, FBgn0026143). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: 3'-5' DNA helicase activity; chromatin binding. There is experimental evidence that it is involved in the biological process: DNA amplification; mitotic cell cycle G2/M transition DNA damage checkpoint; DNA replication; positive regulation of S phase of mitotic cell cycle; chromosome condensation; neurogenesis. 6 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; nuclear chromosome; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: CDC45 family. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1632288_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CDC45L. Gene sequence location is X:922324..924614.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features HFA17747 BKN22191 HFA18164
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 1E1-1E1   Limits computationally determined from genome sequence between P{EP}EP1600&P{EP}EP1498 and P{EP}EP1615&P{EP}EP964
Experimentally Determined Cytological Location
Cytogenetic map Notes References 1E-1F   (determined by in situ hybridisation)   (Loebel et al., 2000) 1E-1E     (Zachar et al., 1987)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CDC45L for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CDC45L-RA FBtr0070182  NM_130524   2239   575
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CDC45L-PA   FBpp0070175   65.9   575   5.40     NP_569880   AAF45579
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • CDC45 family (IPR003874)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142241   AA390476   AE014298 AAF45579   AF081540 AAD09003   AI455980   AI532832   AL109630 CAB51681   AW943302   AY051861 AAK93285   BI171409   BI171410   BI215590   BI234981   BI351779   BI371940   BI585276   BI586031   BI588642   BI610280   BI618760   BI631537   BI636248   CO294396   CO306868   CO340754   EC065896   EC065930   EC071955   EC201447   EC260363   EV600483   FD586222   FD586227   FD586373   FD586600   FD587004   FD587093   FD587483   GH745829   GH748059   GH749598   GH752328   GH755627   GH756961   GH756968   GH771433   GH772460   GH773539   GH775161   GH778472   GH779693   GH780611   GH780992   GH781576   GH787009   GH787995   GH795607   GH796545   GH796967   GH797810   GH799115   GH801102   GH802507   GH806404   GH807532   GH811658   GH813909   GH814323   GH814326   GH815173   GH817177   GH818005   GH821353   GH824823   GH827280   GH829276   GH831558   GH832963   GH833689   GH835954   GH841762   GH845742   GH848176   GH848429   GH855683   GH857746   GH859428   GH860110   GH863413   GH865507   GH869334   GH873257   GH873750   GH878559   GH881916   GH882503   GH890463   GH891719   GH892841   GH894013   GH894665   GH895708   GH898933   GH899154   GH903526   GH909595   GH910676   GH913104   GH913718   GH917477   GH918008   GH918173   GH921821   GH927220   GH927844   GH933452   GH936410   GH936710   GH937174   GH937439
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O96989
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference oogenesis stage S10B   egg chamber   • nucleus (Cayirlioglu et al., 2001)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0026143    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0026143 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0026143 expression level Developmental Stage   Expression Level embryo 00-02hr    8169 embryo 02-04hr    973 embryo 04-06hr    2551 embryo 06-08hr    2286 embryo 08-10hr    1444 embryo 10-12hr    790 embryo 12-14hr    496 embryo 14-16hr    535 embryo 16-18hr    413 embryo 18-20hr    288 embryo 20-22hr    244 embryo 22-24hr    262 larva L1    1132 larva L2    942 larva L3 12hr old    645 larva L3 puffstage 1-2    527 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    655 white prepupae new    523 white prepupae 12hr    829 white prepupae 24hr    680 pupae 2d postWPP    371 pupae 3d postWPP    493 pupae 4d postWPP    778 adult male 01day    476 adult male 05day    367 adult male 30day    379 adult female 01day    2185 adult female 05day    4086 adult female 30day    4393 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8169) embryo 02-04hr  (973) embryo 04-06hr  (2551) embryo 06-08hr  (2286) embryo 08-10hr  (1444) embryo 10-12hr  (790) embryo 12-14hr  (496) embryo 14-16hr  (535) embryo 16-18hr  (413) embryo 18-20hr  (288) embryo 20-22hr  (244) embryo 22-24hr  (262) larva L1  (1132) larva L2  (942) larva L3 12hr old  (645) larva L3 puffstage 1-2  (527) larva L3 puffstage 3-6  (657) larva L3 puffstage 7-9  (655) white prepupae new  (523) white prepupae 12hr  (829) white prepupae 24hr  (680) pupae 2d postWPP  (371) pupae 3d postWPP  (493) pupae 4d postWPP  (778) adult male 01day  (476) adult male 05day  (367) adult male 30day  (379) adult female 01day  (2185) adult female 05day  (4086) adult female 30day  (4393) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8169) embryo 02-04hr    973 embryo 04-06hr  (2551) embryo 06-08hr  (2286) embryo 08-10hr  1444 embryo 10-12hr    790 embryo 12-14hr    496 embryo 14-16hr    535 embryo 16-18hr    413 embryo 18-20hr    288 embryo 20-22hr    244 embryo 22-24hr    262 larva L1    1132 larva L2    942 larva L3 12hr old    645 larva L3 puffstage 1-2    527 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    655 white prepupae new    523 white prepupae 12hr    829 white prepupae 24hr    680 pupae 2d postWPP    371 pupae 3d postWPP    493 pupae 4d postWPP    778 adult male 01day    476 adult male 05day    367 adult male 30day    379 adult female 01day  (2185) adult female 05day  (4086) adult female 30day  (4393) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8169 embryo 02-04hr    973 embryo 04-06hr    2551 embryo 06-08hr    2286 embryo 08-10hr    1444 embryo 10-12hr    790 embryo 12-14hr    496 embryo 14-16hr    535 embryo 16-18hr    413 embryo 18-20hr    288 embryo 20-22hr    244 embryo 22-24hr    262 larva L1    1132 larva L2    942 larva L3 12hr old    645 larva L3 puffstage 1-2    527 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    655 white prepupae new    523 white prepupae 12hr    829 white prepupae 24hr    680 pupae 2d postWPP    371 pupae 3d postWPP    493 pupae 4d postWPP    778 adult male 01day    476 adult male 05day    367 adult male 30day    379 adult female 01day    2185 adult female 05day    4086 adult female 30day    4393 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8169 embryo 02-04hr    973 embryo 04-06hr    2551 embryo 06-08hr    2286 embryo 08-10hr    1444 embryo 10-12hr    790 embryo 12-14hr    496 embryo 14-16hr    535 embryo 16-18hr    413 embryo 18-20hr    288 embryo 20-22hr    244 embryo 22-24hr    262 larva L1    1132 larva L2    942 larva L3 12hr old    645 larva L3 puffstage 1-2    527 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    655 white prepupae new    523 white prepupae 12hr    829 white prepupae 24hr    680 pupae 2d postWPP    371 pupae 3d postWPP    493 pupae 4d postWPP    778 adult male 01day    476 adult male 05day    367 adult male 30day    379 adult female 01day    2185 adult female 05day    4086 adult female 30day    4393 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0026143 expression level Developmental Stage   Expression Level embryo 00-02hr    8169 embryo 02-04hr    973 embryo 04-06hr    2551 embryo 06-08hr    2286 embryo 08-10hr    1444 embryo 10-12hr    790 embryo 12-14hr    496 embryo 14-16hr    535 embryo 16-18hr    413 embryo 18-20hr    288 embryo 20-22hr    244 embryo 22-24hr    262 larva L1    1132 larva L2    942 larva L3 12hr old    645 larva L3 puffstage 1-2    527 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    655 white prepupae new    523 white prepupae 12hr    829 white prepupae 24hr    680 pupae 2d postWPP    371 pupae 3d postWPP    493 pupae 4d postWPP    778 adult male 01day    476 adult male 05day    367 adult male 30day    379 adult female 01day    2185 adult female 05day    4086 adult female 30day    4393 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8169) embryo 02-04hr  (973) embryo 04-06hr  (2551) embryo 06-08hr  (2286) embryo 08-10hr  (1444) embryo 10-12hr  (790) embryo 12-14hr  (496) embryo 14-16hr  (535) embryo 16-18hr  (413) embryo 18-20hr  (288) embryo 20-22hr  (244) embryo 22-24hr  (262) larva L1  (1132) larva L2  (942) larva L3 12hr old  (645) larva L3 puffstage 1-2  (527) larva L3 puffstage 3-6  (657) larva L3 puffstage 7-9  (655) white prepupae new  (523) white prepupae 12hr  (829) white prepupae 24hr  (680) pupae 2d postWPP  (371) pupae 3d postWPP  (493) pupae 4d postWPP  (778) adult male 01day  (476) adult male 05day  (367) adult male 30day  (379) adult female 01day  (2185) adult female 05day  (4086) adult female 30day  (4393) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8169) embryo 02-04hr    973 embryo 04-06hr  (2551) embryo 06-08hr  2286 embryo 08-10hr  1444 embryo 10-12hr    790 embryo 12-14hr    496 embryo 14-16hr    535 embryo 16-18hr    413 embryo 18-20hr    288 embryo 20-22hr    244 embryo 22-24hr    262 larva L1    1132 larva L2    942 larva L3 12hr old    645 larva L3 puffstage 1-2    527 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    655 white prepupae new    523 white prepupae 12hr    829 white prepupae 24hr    680 pupae 2d postWPP    371 pupae 3d postWPP    493 pupae 4d postWPP    778 adult male 01day    476 adult male 05day    367 adult male 30day    379 adult female 01day  2185 adult female 05day  (4086) adult female 30day  (4393) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8169 embryo 02-04hr    973 embryo 04-06hr    2551 embryo 06-08hr    2286 embryo 08-10hr    1444 embryo 10-12hr    790 embryo 12-14hr    496 embryo 14-16hr    535 embryo 16-18hr    413 embryo 18-20hr    288 embryo 20-22hr    244 embryo 22-24hr    262 larva L1    1132 larva L2    942 larva L3 12hr old    645 larva L3 puffstage 1-2    527 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    655 white prepupae new    523 white prepupae 12hr    829 white prepupae 24hr    680 pupae 2d postWPP    371 pupae 3d postWPP    493 pupae 4d postWPP    778 adult male 01day    476 adult male 05day    367 adult male 30day    379 adult female 01day    2185 adult female 05day    4086 adult female 30day    4393 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8169 embryo 02-04hr    973 embryo 04-06hr    2551 embryo 06-08hr    2286 embryo 08-10hr    1444 embryo 10-12hr    790 embryo 12-14hr    496 embryo 14-16hr    535 embryo 16-18hr    413 embryo 18-20hr    288 embryo 20-22hr    244 embryo 22-24hr    262 larva L1    1132 larva L2    942 larva L3 12hr old    645 larva L3 puffstage 1-2    527 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    655 white prepupae new    523 white prepupae 12hr    829 white prepupae 24hr    680 pupae 2d postWPP    371 pupae 3d postWPP    493 pupae 4d postWPP    778 adult male 01day    476 adult male 05day    367 adult male 30day    379 adult female 01day    2185 adult female 05day    4086 adult female 30day    4393 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0026143    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0026143 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0026143 expression level Tissue   Expression Level Larval Central Nervous System    156.175 Larval Midgut    28.3 Larval Hindgut    54.9 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    161.3 Larval Trachea    127.8 Larval Carcass    77.125 Adult Head    41.3 Adult Eye    46.65 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    56.5 Adult Crop    29.5 Adult Midgut    38 Adult Hindgut    28.4 Adult Malpighian Tubules    36.9 Adult Fat Body    35.2 Adult Salivary Gland    63.3 Adult Heart    41.425 Adult VirginFemale Spermatheca    31.5 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    424 Adult Testis    25.4 Adult Male Accessory Gland    43.6 Adult Carcass    48.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    156.175 Larval Midgut    28.3 Larval Hindgut    54.9 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    161.3 Larval Trachea    127.8 Larval Carcass    77.125 Adult Head    41.3 Adult Eye    46.65 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    56.5 Adult Crop    29.5 Adult Midgut    38 Adult Hindgut    28.4 Adult Malpighian Tubules    36.9 Adult Fat Body    35.2 Adult Salivary Gland    63.3 Adult Heart    41.425 Adult VirginFemale Spermatheca    31.5 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    424 Adult Testis    25.4 Adult Male Accessory Gland    43.6 Adult Carcass    48.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    156.175 Larval Midgut    28.3 Larval Hindgut    54.9 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    161.3 Larval Trachea    127.8 Larval Carcass    77.125 Adult Head    41.3 Adult Eye    46.65 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    56.5 Adult Crop    29.5 Adult Midgut    38 Adult Hindgut    28.4 Adult Malpighian Tubules    36.9 Adult Fat Body    35.2 Adult Salivary Gland    63.3 Adult Heart    41.425 Adult VirginFemale Spermatheca    31.5 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    424 Adult Testis    25.4 Adult Male Accessory Gland    43.6 Adult Carcass    48.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    156.175 Larval Midgut    28.3 Larval Hindgut    54.9 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    161.3 Larval Trachea    127.8 Larval Carcass    77.125 Adult Head    41.3 Adult Eye    46.65 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    56.5 Adult Crop    29.5 Adult Midgut    38 Adult Hindgut    28.4 Adult Malpighian Tubules    36.9 Adult Fat Body    35.2 Adult Salivary Gland    63.3 Adult Heart    41.425 Adult VirginFemale Spermatheca    31.5 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    424 Adult Testis    25.4 Adult Male Accessory Gland    43.6 Adult Carcass    48.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0026143 expression level Tissue   Expression Level Larval Central Nervous System    156.175 Larval Midgut    28.3 Larval Hindgut    54.9 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    161.3 Larval Trachea    127.8 Larval Carcass    77.125 Adult Head    41.3 Adult Eye    46.65 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    56.5 Adult Crop    29.5 Adult Midgut    38 Adult Hindgut    28.4 Adult Malpighian Tubules    36.9 Adult Fat Body    35.2 Adult Salivary Gland    63.3 Adult Heart    41.425 Adult VirginFemale Spermatheca    31.5 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    424 Adult Testis    25.4 Adult Male Accessory Gland    43.6 Adult Carcass    48.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    156.175 Larval Midgut    28.3 Larval Hindgut    54.9 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    161.3 Larval Trachea    127.8 Larval Carcass    77.125 Adult Head    41.3 Adult Eye    46.65 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    56.5 Adult Crop    29.5 Adult Midgut    38 Adult Hindgut    28.4 Adult Malpighian Tubules    36.9 Adult Fat Body    35.2 Adult Salivary Gland    63.3 Adult Heart    41.425 Adult VirginFemale Spermatheca    31.5 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    424 Adult Testis    25.4 Adult Male Accessory Gland    43.6 Adult Carcass    48.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    156.175 Larval Midgut    28.3 Larval Hindgut    54.9 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    161.3 Larval Trachea    127.8 Larval Carcass    77.125 Adult Head    41.3 Adult Eye    46.65 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    56.5 Adult Crop    29.5 Adult Midgut    38 Adult Hindgut    28.4 Adult Malpighian Tubules    36.9 Adult Fat Body    35.2 Adult Salivary Gland    63.3 Adult Heart    41.425 Adult VirginFemale Spermatheca    31.5 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    424 Adult Testis    25.4 Adult Male Accessory Gland    43.6 Adult Carcass    48.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    156.175 Larval Midgut    28.3 Larval Hindgut    54.9 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    161.3 Larval Trachea    127.8 Larval Carcass    77.125 Adult Head    41.3 Adult Eye    46.65 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    56.5 Adult Crop    29.5 Adult Midgut    38 Adult Hindgut    28.4 Adult Malpighian Tubules    36.9 Adult Fat Body    35.2 Adult Salivary Gland    63.3 Adult Heart    41.425 Adult VirginFemale Spermatheca    31.5 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    424 Adult Testis    25.4 Adult Male Accessory Gland    43.6 Adult Carcass    48.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    41.3   NA  Eye    46.65   NA  Brain    63.1   156.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    56.5   NA  Crop    29.5   28.3  Midgut    38   54.9  Hindgut    28.4   no informative data  Malpighian Tubules    36.9   no informative data  Fat Body    35.2   161.3  Salivary Gland    63.3   NA  Heart    41.425   127.8  Trachea    NA   NA  VirginFemale Spermatheca    31.5   NA  InseminatedFemale Spermatheca    37.4   NA  Ovary    424   NA  Testis    25.4   NA  Male Accessory Gland    43.6   77.125  Carcass    48.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026143 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3658-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 CDC45LGD4421 CDC45LGD9657 viable, with Scer\GAL4pnr-MD237 CDC45LGD4421 CDC45LGD9657 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 CDC45LGD4421 CDC45LGD9657 radiation sensitive, with Scer\GAL4ap-md544 CDC45LNIG.3658R visible, with Scer\GAL4pnr-MD237 CDC45LGD4421 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 CDC45LGD4421 CDC45LGD9657 ganglion mother cell | larval stage, with Scer\GAL41407 CDC45LGD4421 CDC45LGD9657 mesothoracic tergum, with Scer\GAL4pnr-MD237 CDC45LGD4421 nuclear chromosome CDC45LdsRNA.cCa trichogen cell, with Scer\GAL4pnr-MD237 CDC45LGD4421
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CDC45L Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CDC45L Class Mutagen Stocks Known lesion CDC45LGD4421 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CDC45LGD9657 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CDC45LdsRNA.cCa in vitro construct - RNAi 0 Yes CDC45LKK102125 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CDC45LNIG.3658R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CDC45LSWAP2 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6225 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4421} NA P{GD9657} NA P{KK102125} NA characterization construct P{NIG.3658R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}KG01754 NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
contributes_to 3'-5' DNA helicase activity inferred from direct assay (Moyer et al., 2006) chromatin binding inferred from direct assay (Loebel et al., 2000)
Biological Process
CV term Evidence References
chromosome condensation inferred from mutant phenotype (Christensen and Tye, 2003) DNA amplification inferred from expression pattern (Loebel et al., 2000) DNA replication inferred from physical interaction with Mcm5 AND inferred from physical interaction with dpa (Loebel et al., 2000) mitotic cell cycle G2/M transition DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) inferred from mutant phenotype (Kondo and Perrimon, 2011) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) positive regulation of S phase of mitotic cell cycle inferred from mutant phenotype (Moyer et al., 2006)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Loebel et al., 2000) nucleus inferred from direct assay (Loebel et al., 2000) pre-replicative complex inferred from physical interaction with Mcm5 AND inferred from physical interaction with dpa AND inferred from sequence or structural similarity with human CDC45L AND inferred from sequence or structural similarity with Saccharomyces CDC45 (Loebel et al., 2000)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from sequence or structural similarity with EMBL:AF062494 (FlyBase, 1992-)
Biological Process
CV term Evidence References
DNA-dependent DNA replication initiation inferred from sequence or structural similarity with human CDC45L AND inferred from sequence or structural similarity with Saccharomyces CDC45 (Loebel et al., 2000) DNA replication inferred from sequence or structural similarity with EMBL:AF062494 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
pre-replicative complex inferred from sequence or structural similarity with EMBL:AF062494 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CDC45L allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57617 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026143 DroID - A comprehensive database of gene and protein interactions. • FBgn0026143 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31052
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22037 Dere\GG12721 Dgri\GH12736 Dmoj\GI14991 Dper\GL14405 Dpse\GA17594 Dsec\GM19000 Dsim\GD16439 Dvir\GJ15347 Dwil\GK16247 Dyak\GE16547
Curated drosophilid orthologs	Dpse\GA17594
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007939-PA Aedes aegypti (mosquito) AAEL015080-PA Aedes aegypti (mosquito) AGAP011961-PA Anopheles gambiae (mosquito) XP_393560.3 Apis mellifera (honey bee) XP_001952289.1 Acyrthosiphon pisum (pea aphid) At3g25100.1 Arabidopsis thaliana (wall cress) 18021 Batrachochytrium dendrobatidis (chytrid fungus) 267641 Branchiostoma floridae (lancelet) XP_001895040.1 Brugia malayi (roundworm nematode) BGIBMGA013084-PA Bombyx mori (silk worm) ENSBTAP00000005623 Bos taurus (bovine) CAL0002709 Candida albicans (a form of yeast) CN00316 Caenorhabditis brenneri (small nematode) CBP02262 Caenorhabditis briggsae (nematode) CE41399 Caenorhabditis elegans (worm) ENSCAFP00000021510 Canis familiaris (dog) CAGL0M11550g Candida glabrata (haploid yeast) Chro.80279 Cryptosporidium hominis (obligate parasite) ENSCINP00000010855 Ciona intestinalis (sea squirt) JA02106 Caenorhabditis japonica (nematode) cn05148 Cryptococcus neoformans (yeast-like fungus) cgd8_2380 Cryptosporidium parvum (protozoan parasite) CPIJ004442 Culex pipens (mosquito) ENSCPOP00000002061 Cavia porcellus (guinea pig) 142125 Chlamidomonas reinhardtii (green alga) RP47677 Caenorhabditis remanei (nematode) ENSCSAVP00000020129 Ciona savignyi (sedentary tunicate) 224008 Capitella spl (polychaete worm) DDB0237549 Dictyostelium discoideum (amoeba) DEHA2E20416g Debaryomyces Hansenii (yeast) 302385 Daphnia pulex (daphnia) ENSDARP00000064200 Danio rerio (zebra fish) ENSECAP00000009663 Equus caballus (horse) XP_657172 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000007418 Gymnopilus aculeatus (mushroom) ENSGALP00000002461 Gallus gallus (chicken) 157531 Hypsipyla robusta (cedar shoot borer) ENSP00000385240 Homo sapiens (human) ISCW008147-PA Ixodes scapularis (deer tick) KLLA0F19822g Kluyveromyces lactis (yeast) 206668 Lottia gigantea (owl limpet) 25659 Monocosta brevicollis (choanoflagellate) ENSMODP00000012721 Monodelphis domestica (gray opossum) ENSMMUP00000028842 Macaca mulatta (rhesus monkey) ENSMUSP00000111249 Mus musculus (house mouse) 79419 Nematostella vectensis (starlet anemone) ENSOANP00000026695 Ornithorynchus anatinus (platypus) ENSORLP00000003399 Oryzias latipes (japanese killifish) LOC_Os11g03430.1 Oryza sativa (asian rice) LOC_Os12g03130.1 Oryza sativa (asian rice) 10803 Ostreococcus tauri (green alga) PP06814 Pristionchus pacificus (nematode) 105803 Physcomitrella patens (moss) ENSPPYP00000012918 Pongo pygmaeus (orangutan) 75703 Phytophthora ramorum (sudden oak death pathogen) 138075 Phytophthora sojae (root rot pathogen) 666600 Populus trichocarpa (black cottonwood) ENSPTRP00000024215 Pan troglodytes (chimpanzee) 4820393 Sorghum bicolor (sorghum) YLR103C Saccharomyces cerevisiae (budding yeast) Smp_047610 Schistosoma mansoni (trematode parasite) SPAC17D4.02 Schizosaccharomyces pombe (fission yeast) XP_001180929.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001183098.1 Strongylocentrotus purpuratus (purple sea urchin) XP_787240.2 Strongylocentrotus purpuratus (purple sea urchin) 58320 Trichoplax adhaerens (metazoa) XP_972485.2 Tribolium castaneum (red flour beetle) Tc00.1047053506303.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506811.210 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000019014 Tetraodon nigroviridis (green spotted pufferfish) 264672 Thalassiosira pseudonana (marine diatom) ENSTRUP00000042171 Takifugu rubripes (pufferfish Takifugu) 3675.m00033 Tetrahymena thermophila (ciliate protozoa) 84458.m00211 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000040268 Xenopus tropicalis (frog) YALI0B06369g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17071 NV50079 LH23273 ISCW008147 FBgn0234062 FBgn0218249 FBgn0202541 FBgn0188054 FBgn0173903 JGI_V11_302385 FBgn0077605 FBgn0152010 FBgn0137742 FBgn0120215 FBgn0105008 FBgn0099036 CPIJ004442 BGIBMGA013084 ACYPI009008 ACYPI008230 GB17770 AGAP011961 AAEL015080 AAEL007939 PHUM214750 GLEAN_15858
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v20705 w1118; P{GD9657}v20705 v41084 w1118; P{GD4421}v41084
Genomic Clones ( 1 )
	BACR29P19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 116 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35753
Other clones	DPiM_LD35753
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM16091 LD08729 RE13180 RE13181 RE22141 RE30766 RE58974 RH15391 RH24864 RH25751 RH30029 RH49662 RH61134 SD04460 SD17871
Other clones	10728 76547 145176 145839 214221.16 CK00017 Dmel_neb_015682_0933_2840 EK206830 EK252634 EP11261 RM01041 RM01241 RM01341 RM01441 RM01541 RM01641 RM01741 RP001016649 RP001032251 RP003011412 RP003012927 RP003019861 RP003022907 RP003026844 RP003033367 RP003043392 RP003050075 RP003065845 RP003084322 RP003089556 RP003100470 RP003107863 RP003108632 RP003134216 RP003142293 RP003145677 RP003150707 RP003150787 RP003151884 RP003155277 RP003157349 RP003173980 RP003175658 RP003186643 RP003197020 RP003208426 RP003209392 RP003214730 RP003230871 RP003239150 RP003242804 RP003246165 RP003255127 RP003260181 RP003263636 RP003264879 RP003271792 RP003274366 RP003291782 RP003299448 RP003300208 RP003307034 RP003319831 RP003326395 RP003341116 RP003344640 RP003367336 RP003393386 RP003394420 RP003409481 RP003412641 RP003413175 RP003436017 RP003445147 RP003452680 RP003453457 RP003462848 RP003509010 RP003546537 RP003552217 RP003555732 RP003557718 RP003564230 RP003565914 RP003566194 RP003574950 RP003581245 RP003586566 RP003588569 RP003605422 RP003609894 RP003615860 RP003625860 RP003630738 RP003649412 RP003651341 RP003654637 RP003660227 RP003662013
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026143 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31052
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CDC45L anon-1Ec (Gatt and Ashburner, 2000.2.3)
Additional comments
Other Comments
	The Sld5, Psf1, Psf2, Psf3, CDC45L, Mcm2, Mcm3, Mcm5, Mcm6, Mcm7 and dpa proteins form the Cdc45/Mcm2-7/GINS (CMG) complex, a helicase required for the S phase transition in Kc cells. (Moyer et al., 2006) Kc cells transfected with dsRNA made from templates generated with primers directed against this gene show an impairment of the cell cycle and accumulate in G1 and S phase. (Moyer et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_130524 RefSeq (Proteins) • NP_569880 DDBJ / EMBL / GenBank • AA390476 AAD09003 AAF45579 AAK93285 AF081540 AI455980 AL109630 AW943302 AY051861 CAB51681 Entrez Gene - A searchable database of RefSeq genes. • 31052 UniProtKB/TrEMBL • O96989
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • CDC45 family (IPR003874)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57617 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026143 DroID - A comprehensive database of gene and protein interactions. • FBgn0026143 DRSC - Results from RNAi screens. • FBgn0026143 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026143 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3658-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026143 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31052 InParanoid A subset of ortholog calls from InParanoid. • AAEL007939-PA Aedes aegypti (mosquito) AAEL015080-PA Aedes aegypti (mosquito) AGAP011961-PA Anopheles gambiae (mosquito) XP_393560.3 Apis mellifera (honey bee) XP_001952289.1 Acyrthosiphon pisum (pea aphid) At3g25100.1 Arabidopsis thaliana (wall cress) 18021 Batrachochytrium dendrobatidis (chytrid fungus) 267641 Branchiostoma floridae (lancelet) XP_001895040.1 Brugia malayi (roundworm nematode) BGIBMGA013084-PA Bombyx mori (silk worm) ENSBTAP00000005623 Bos taurus (bovine) CAL0002709 Candida albicans (a form of yeast) CN00316 Caenorhabditis brenneri (small nematode) CBP02262 Caenorhabditis briggsae (nematode) CE41399 Caenorhabditis elegans (worm) ENSCAFP00000021510 Canis familiaris (dog) CAGL0M11550g Candida glabrata (haploid yeast) Chro.80279 Cryptosporidium hominis (obligate parasite) ENSCINP00000010855 Ciona intestinalis (sea squirt) JA02106 Caenorhabditis japonica (nematode) cn05148 Cryptococcus neoformans (yeast-like fungus) cgd8_2380 Cryptosporidium parvum (protozoan parasite) CPIJ004442 Culex pipens (mosquito) ENSCPOP00000002061 Cavia porcellus (guinea pig) 142125 Chlamidomonas reinhardtii (green alga) RP47677 Caenorhabditis remanei (nematode) ENSCSAVP00000020129 Ciona savignyi (sedentary tunicate) 224008 Capitella spl (polychaete worm) DDB0237549 Dictyostelium discoideum (amoeba) DEHA2E20416g Debaryomyces Hansenii (yeast) 302385 Daphnia pulex (daphnia) ENSDARP00000064200 Danio rerio (zebra fish) ENSECAP00000009663 Equus caballus (horse) XP_657172 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000007418 Gymnopilus aculeatus (mushroom) ENSGALP00000002461 Gallus gallus (chicken) 157531 Hypsipyla robusta (cedar shoot borer) ENSP00000385240 Homo sapiens (human) ISCW008147-PA Ixodes scapularis (deer tick) KLLA0F19822g Kluyveromyces lactis (yeast) 206668 Lottia gigantea (owl limpet) 25659 Monocosta brevicollis (choanoflagellate) ENSMODP00000012721 Monodelphis domestica (gray opossum) ENSMMUP00000028842 Macaca mulatta (rhesus monkey) ENSMUSP00000111249 Mus musculus (house mouse) 79419 Nematostella vectensis (starlet anemone) ENSOANP00000026695 Ornithorynchus anatinus (platypus) ENSORLP00000003399 Oryzias latipes (japanese killifish) LOC_Os11g03430.1 Oryza sativa (asian rice) LOC_Os12g03130.1 Oryza sativa (asian rice) 10803 Ostreococcus tauri (green alga) PP06814 Pristionchus pacificus (nematode) 105803 Physcomitrella patens (moss) ENSPPYP00000012918 Pongo pygmaeus (orangutan) 75703 Phytophthora ramorum (sudden oak death pathogen) 138075 Phytophthora sojae (root rot pathogen) 666600 Populus trichocarpa (black cottonwood) ENSPTRP00000024215 Pan troglodytes (chimpanzee) 4820393 Sorghum bicolor (sorghum) YLR103C Saccharomyces cerevisiae (budding yeast) Smp_047610 Schistosoma mansoni (trematode parasite) SPAC17D4.02 Schizosaccharomyces pombe (fission yeast) XP_001180929.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001183098.1 Strongylocentrotus purpuratus (purple sea urchin) XP_787240.2 Strongylocentrotus purpuratus (purple sea urchin) 58320 Trichoplax adhaerens (metazoa) XP_972485.2 Tribolium castaneum (red flour beetle) Tc00.1047053506303.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506811.210 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000019014 Tetraodon nigroviridis (green spotted pufferfish) 264672 Thalassiosira pseudonana (marine diatom) ENSTRUP00000042171 Takifugu rubripes (pufferfish Takifugu) 3675.m00033 Tetrahymena thermophila (ciliate protozoa) 84458.m00211 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000040268 Xenopus tropicalis (frog) YALI0B06369g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31052 modMine - Data generated by the modENCODE project. • FBgn0026143 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17071 NV50079 LH23273 ISCW008147 FBgn0234062 FBgn0218249 FBgn0202541 FBgn0188054 FBgn0173903 JGI_V11_302385 FBgn0077605 FBgn0152010 FBgn0137742 FBgn0120215 FBgn0105008 FBgn0099036 CPIJ004442 BGIBMGA013084 ACYPI009008 ACYPI008230 GB17770 AGAP011961 AAEL015080 AAEL007939 PHUM214750 GLEAN_15858
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	anon-1Ec   CDC45 (Bandura et al., 2005) Cdc45 (Christensen and Tye, 2003, Tower, 2004, Cayirlioglu and Duronio, 2001, Cayirlioglu et al., 2001, Moyer et al., 2006, Riddihough, 2006, Foglietti et al., 2006, Hediger and Gasser, 2006, Ilves et al., 2010) CDC45L (De Lucia et al., 2005, Cayirlioglu et al., 2003, Kondo and Perrimon, 2011, Neumüller et al., 2011) CG3658 (Dimova et al., 2003, Brody et al., 2002, Jin et al., 2001, Benos, 2000.12.13, Keleman et al., 2009.8.5) D (Zachar et al., 1987) dCDC45 (Crevel et al., 2007) DmCdc45 (Loebel et al., 2000) EG:BACR7A4.11 (Benos, 1999.12.13, Benos et al., 2001, Benos, 2000.12.13)
Name Synonym	CDC45L   Transcription unit D (Zachar et al., 1987)
Secondary FlyBase IDs
	FBgn0014904
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 18 ) Supplementary material  ( 4 ) Review  ( 4 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Ilves et al., 2010, Mol. Cell 37(2): 247--258 Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins. [FBrf0209843] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...