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Gene Dmel\skpB

General Information
Symbol	Dmel\skpB	Species	D. melanogaster
Name	skpB	Annotation symbol	CG8881
Feature type	protein_coding_gene	FlyBase ID	FBgn0026176
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	48E2-48E2	Sequence location	2R:8,026,800..8,027,567 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene skpB is referred to in FlyBase by the symbol Dmel\skpB (CG8881, FBgn0026176). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: ubiquitin-dependent protein catabolic process. 2 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: BTB/POZ fold; E3 ubiquitin ligase, SCF complex, Skp subunit; SKP1 component; SKP1 component, POZ; SKP1 component, dimerisation. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1636591_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of skpB. Gene sequence location is 2R:8026800..8027567.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN31868 HFA07683
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 48E2-48E2   Limits computationally determined from genome sequence between P{lacW}jebk05644 and P{PZ}SmD302833
Experimentally Determined Cytological Location
Cytogenetic map Notes References 48F-48F     (Murphy, 1999.12.29)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\skpB for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) skpB-RA FBtr0088020  NM_136885   710   161
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein skpB-PA   FBpp0087127   18.4   161   4.17     NP_610729   AAF58579
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ fold (IPR011333) SKP1 component (IPR001232) SKP1 component, dimerisation (IPR016072) SKP1 component, POZ (IPR016073) E3 ubiquitin ligase, SCF complex, Skp subunit (IPR016897)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58579   AF220067 AAF64675   BE977618   BE977787   BT023253   BT088825   EC261963
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KJ69
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0026176    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0026176 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0026176 expression level Developmental Stage   Expression Level embryo 00-02hr    114 embryo 02-04hr    133 embryo 04-06hr    138 embryo 06-08hr    64 embryo 08-10hr    104 embryo 10-12hr    172 embryo 12-14hr    133 embryo 14-16hr    242 embryo 16-18hr    289 embryo 18-20hr    205 embryo 20-22hr    163 embryo 22-24hr    134 larva L1    149 larva L2    100 larva L3 12hr old    83 larva L3 puffstage 1-2    640 larva L3 puffstage 3-6    1047 larva L3 puffstage 7-9    1337 white prepupae new    1153 white prepupae 12hr    2209 white prepupae 24hr    2622 pupae 2d postWPP    2988 pupae 3d postWPP    7323 pupae 4d postWPP    7729 adult male 01day    7284 adult male 05day    5904 adult male 30day    5234 adult female 01day    2126 adult female 05day    207 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (114) embryo 02-04hr  (133) embryo 04-06hr  (138) embryo 06-08hr    64 embryo 08-10hr  104 embryo 10-12hr  (172) embryo 12-14hr  (133) embryo 14-16hr  (242) embryo 16-18hr  (289) embryo 18-20hr  (205) embryo 20-22hr  (163) embryo 22-24hr  (134) larva L1  (149) larva L2    100 larva L3 12hr old    83 larva L3 puffstage 1-2  (640) larva L3 puffstage 3-6  (1047) larva L3 puffstage 7-9  (1337) white prepupae new  (1153) white prepupae 12hr  (2209) white prepupae 24hr  (2622) pupae 2d postWPP  (2988) pupae 3d postWPP  (7323) pupae 4d postWPP  (7729) adult male 01day  (7284) adult male 05day  (5904) adult male 30day  (5234) adult female 01day  (2126) adult female 05day  (207) adult female 30day  (109) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    114 embryo 02-04hr    133 embryo 04-06hr    138 embryo 06-08hr    64 embryo 08-10hr    104 embryo 10-12hr    172 embryo 12-14hr    133 embryo 14-16hr    242 embryo 16-18hr    289 embryo 18-20hr    205 embryo 20-22hr    163 embryo 22-24hr    134 larva L1    149 larva L2    100 larva L3 12hr old    83 larva L3 puffstage 1-2    640 larva L3 puffstage 3-6    1047 larva L3 puffstage 7-9    1337 white prepupae new    1153 white prepupae 12hr  (2209) white prepupae 24hr  (2622) pupae 2d postWPP  (2988) pupae 3d postWPP  (7323) pupae 4d postWPP  (7729) adult male 01day  (7284) adult male 05day  (5904) adult male 30day  (5234) adult female 01day  (2126) adult female 05day    207 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    114 embryo 02-04hr    133 embryo 04-06hr    138 embryo 06-08hr    64 embryo 08-10hr    104 embryo 10-12hr    172 embryo 12-14hr    133 embryo 14-16hr    242 embryo 16-18hr    289 embryo 18-20hr    205 embryo 20-22hr    163 embryo 22-24hr    134 larva L1    149 larva L2    100 larva L3 12hr old    83 larva L3 puffstage 1-2    640 larva L3 puffstage 3-6    1047 larva L3 puffstage 7-9    1337 white prepupae new    1153 white prepupae 12hr    2209 white prepupae 24hr    2622 pupae 2d postWPP    2988 pupae 3d postWPP    7323 pupae 4d postWPP    7729 adult male 01day    7284 adult male 05day    5904 adult male 30day    5234 adult female 01day    2126 adult female 05day    207 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    114 embryo 02-04hr    133 embryo 04-06hr    138 embryo 06-08hr    64 embryo 08-10hr    104 embryo 10-12hr    172 embryo 12-14hr    133 embryo 14-16hr    242 embryo 16-18hr    289 embryo 18-20hr    205 embryo 20-22hr    163 embryo 22-24hr    134 larva L1    149 larva L2    100 larva L3 12hr old    83 larva L3 puffstage 1-2    640 larva L3 puffstage 3-6    1047 larva L3 puffstage 7-9    1337 white prepupae new    1153 white prepupae 12hr    2209 white prepupae 24hr    2622 pupae 2d postWPP    2988 pupae 3d postWPP    7323 pupae 4d postWPP    7729 adult male 01day    7284 adult male 05day    5904 adult male 30day    5234 adult female 01day    2126 adult female 05day    207 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0026176 expression level Developmental Stage   Expression Level embryo 00-02hr    114 embryo 02-04hr    133 embryo 04-06hr    138 embryo 06-08hr    64 embryo 08-10hr    104 embryo 10-12hr    172 embryo 12-14hr    133 embryo 14-16hr    242 embryo 16-18hr    289 embryo 18-20hr    205 embryo 20-22hr    163 embryo 22-24hr    134 larva L1    149 larva L2    100 larva L3 12hr old    83 larva L3 puffstage 1-2    640 larva L3 puffstage 3-6    1047 larva L3 puffstage 7-9    1337 white prepupae new    1153 white prepupae 12hr    2209 white prepupae 24hr    2622 pupae 2d postWPP    2988 pupae 3d postWPP    7323 pupae 4d postWPP    7729 adult male 01day    7284 adult male 05day    5904 adult male 30day    5234 adult female 01day    2126 adult female 05day    207 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  114 embryo 02-04hr  133 embryo 04-06hr  138 embryo 06-08hr    64 embryo 08-10hr  104 embryo 10-12hr  (172) embryo 12-14hr  133 embryo 14-16hr  (242) embryo 16-18hr  (289) embryo 18-20hr  (205) embryo 20-22hr  (163) embryo 22-24hr  134 larva L1  (149) larva L2    100 larva L3 12hr old    83 larva L3 puffstage 1-2  (640) larva L3 puffstage 3-6  (1047) larva L3 puffstage 7-9  (1337) white prepupae new  (1153) white prepupae 12hr  (2209) white prepupae 24hr  (2622) pupae 2d postWPP  (2988) pupae 3d postWPP  (7323) pupae 4d postWPP  (7729) adult male 01day  (7284) adult male 05day  (5904) adult male 30day  (5234) adult female 01day  (2126) adult female 05day  (207) adult female 30day  109 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    114 embryo 02-04hr    133 embryo 04-06hr    138 embryo 06-08hr    64 embryo 08-10hr    104 embryo 10-12hr    172 embryo 12-14hr    133 embryo 14-16hr    242 embryo 16-18hr    289 embryo 18-20hr    205 embryo 20-22hr    163 embryo 22-24hr    134 larva L1    149 larva L2    100 larva L3 12hr old    83 larva L3 puffstage 1-2    640 larva L3 puffstage 3-6    1047 larva L3 puffstage 7-9    1337 white prepupae new    1153 white prepupae 12hr  2209 white prepupae 24hr  (2622) pupae 2d postWPP  (2988) pupae 3d postWPP  (7323) pupae 4d postWPP  (7729) adult male 01day  (7284) adult male 05day  (5904) adult male 30day  (5234) adult female 01day  2126 adult female 05day    207 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    114 embryo 02-04hr    133 embryo 04-06hr    138 embryo 06-08hr    64 embryo 08-10hr    104 embryo 10-12hr    172 embryo 12-14hr    133 embryo 14-16hr    242 embryo 16-18hr    289 embryo 18-20hr    205 embryo 20-22hr    163 embryo 22-24hr    134 larva L1    149 larva L2    100 larva L3 12hr old    83 larva L3 puffstage 1-2    640 larva L3 puffstage 3-6    1047 larva L3 puffstage 7-9    1337 white prepupae new    1153 white prepupae 12hr    2209 white prepupae 24hr    2622 pupae 2d postWPP    2988 pupae 3d postWPP    7323 pupae 4d postWPP    7729 adult male 01day    7284 adult male 05day    5904 adult male 30day    5234 adult female 01day    2126 adult female 05day    207 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    114 embryo 02-04hr    133 embryo 04-06hr    138 embryo 06-08hr    64 embryo 08-10hr    104 embryo 10-12hr    172 embryo 12-14hr    133 embryo 14-16hr    242 embryo 16-18hr    289 embryo 18-20hr    205 embryo 20-22hr    163 embryo 22-24hr    134 larva L1    149 larva L2    100 larva L3 12hr old    83 larva L3 puffstage 1-2    640 larva L3 puffstage 3-6    1047 larva L3 puffstage 7-9    1337 white prepupae new    1153 white prepupae 12hr    2209 white prepupae 24hr    2622 pupae 2d postWPP    2988 pupae 3d postWPP    7323 pupae 4d postWPP    7729 adult male 01day    7284 adult male 05day    5904 adult male 30day    5234 adult female 01day    2126 adult female 05day    207 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0026176    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0026176 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0026176 expression level Tissue   Expression Level Larval Central Nervous System    5.575 Larval Midgut no informative data Larval Hindgut    4.4 Larval Malpighian Tubules no informative data Larval Fat Body    88.7 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    174.25 Adult Head    14.2 Adult Eye no informative data Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    9.7 Adult Malpighian Tubules    5 Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    5.8 Adult Testis    627.8 Adult Male Accessory Gland no informative data Adult Carcass    77.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.575 Larval Midgut no informative data Larval Hindgut    4.4 Larval Malpighian Tubules no informative data Larval Fat Body    88.7 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    174.25 Adult Head    14.2 Adult Eye no informative data Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    9.7 Adult Malpighian Tubules    5 Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    5.8 Adult Testis  (627.8) Adult Male Accessory Gland no informative data Adult Carcass    77.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.575 Larval Midgut no informative data Larval Hindgut    4.4 Larval Malpighian Tubules no informative data Larval Fat Body    88.7 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    174.25 Adult Head    14.2 Adult Eye no informative data Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    9.7 Adult Malpighian Tubules    5 Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    5.8 Adult Testis    627.8 Adult Male Accessory Gland no informative data Adult Carcass    77.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.575 Larval Midgut no informative data Larval Hindgut    4.4 Larval Malpighian Tubules no informative data Larval Fat Body    88.7 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    174.25 Adult Head    14.2 Adult Eye no informative data Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    9.7 Adult Malpighian Tubules    5 Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    5.8 Adult Testis    627.8 Adult Male Accessory Gland no informative data Adult Carcass    77.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0026176 expression level Tissue   Expression Level Larval Central Nervous System    5.575 Larval Midgut no informative data Larval Hindgut    4.4 Larval Malpighian Tubules no informative data Larval Fat Body    88.7 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    174.25 Adult Head    14.2 Adult Eye no informative data Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    9.7 Adult Malpighian Tubules    5 Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    5.8 Adult Testis    627.8 Adult Male Accessory Gland no informative data Adult Carcass    77.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.575 Larval Midgut no informative data Larval Hindgut    4.4 Larval Malpighian Tubules no informative data Larval Fat Body    88.7 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    174.25 Adult Head    14.2 Adult Eye no informative data Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    9.7 Adult Malpighian Tubules    5 Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    5.8 Adult Testis  627.8 Adult Male Accessory Gland no informative data Adult Carcass    77.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.575 Larval Midgut no informative data Larval Hindgut    4.4 Larval Malpighian Tubules no informative data Larval Fat Body    88.7 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    174.25 Adult Head    14.2 Adult Eye no informative data Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    9.7 Adult Malpighian Tubules    5 Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    5.8 Adult Testis    627.8 Adult Male Accessory Gland no informative data Adult Carcass    77.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.575 Larval Midgut no informative data Larval Hindgut    4.4 Larval Malpighian Tubules no informative data Larval Fat Body    88.7 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    174.25 Adult Head    14.2 Adult Eye no informative data Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    9.7 Adult Malpighian Tubules    5 Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    7.2 Adult Ovary    5.8 Adult Testis    627.8 Adult Male Accessory Gland no informative data Adult Carcass    77.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    14.2   NA  Eye    no informative data   NA  Brain    5.8   5.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    8.2   NA  Crop    8.9   no informative data  Midgut    no informative data   4.4  Hindgut    9.7   no informative data  Malpighian Tubules    5   88.7  Fat Body    8.6   no informative data  Salivary Gland    no informative data   NA  Heart    4.5   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    5.8   NA  InseminatedFemale Spermatheca    7.2   NA  Ovary    5.8   NA  Testis    627.8   NA  Male Accessory Gland    no informative data   174.25  Carcass    77.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026176 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8881-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 skpBGD14056 Other Phenotypes Allele planar polarity defective, with Scer\GAL4pnr-MD237 skpBGD14056 visible, with Scer\GAL4pnr-MD237 skpBGD14056 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 skpBGD14056
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of skpB Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of skpB Class Mutagen Stocks Known lesion skpBGD14056 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes skpBKK111868 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14056} NA P{KK111868} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
ubiquitin-dependent protein catabolic process inferred from electronic annotation with InterPro:IPR001232, InterPro:IPR016072, InterPro:IPR016073 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions skpB allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62080 DroID - A comprehensive database of gene and protein interactions. • FBgn0026176 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36298
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12644 Dere\GG22608 Dgri\GH20861 Dmoj\GI20969 Dper\GL16990 Dpse\GA21386 Dsec\GM20386 Dsim\GD25859 Dvir\GJ20688 Dwil\GK21342 Dyak\GE13476
Curated drosophilid orthologs	Dpse\GA21386
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • CN11041 Caenorhabditis brenneri (small nematode) CN13105 Caenorhabditis brenneri (small nematode) CN13922 Caenorhabditis brenneri (small nematode) CN18738 Caenorhabditis brenneri (small nematode) CN20932 Caenorhabditis brenneri (small nematode) CN28973 Caenorhabditis brenneri (small nematode) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0231145 FBgn0223334 FBgn0207826 FBgn0197141 FBgn0197139 FBgn0175269 FBgn0081374 FBgn0154594 FBgn0143703 FBgn0128323 FBgn0114779 FBgn0089680 FBgn0088176
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v106521 P{KK111868}VIE-260B v28974 w1118; P{GD14056}v28974 v28975 w1118; P{GD14056}v28975
Genomic Clones ( 1 )
	BACR04E21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP02725
Other clones	IP02726
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	524260 bs66h08 bs69b02
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026176 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36298
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: skpB CG8881 (FlyBase, 1996-)
Additional comments	Source for merge of skpB CG8881 was sequence comparison (date:000423). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136885 RefSeq (Proteins) • NP_610729 DDBJ / EMBL / GenBank • AAF58579 AAF64675 AF220067 Entrez Gene - A searchable database of RefSeq genes. • 36298 UniProtKB/TrEMBL • Q7KJ69
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ fold (IPR011333) SKP1 component (IPR001232) SKP1 component, dimerisation (IPR016072) SKP1 component, POZ (IPR016073) E3 ubiquitin ligase, SCF complex, Skp subunit (IPR016897)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62080 DroID - A comprehensive database of gene and protein interactions. • FBgn0026176 DRSC - Results from RNAi screens. • FBgn0026176 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026176 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8881-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026176 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36298 InParanoid A subset of ortholog calls from InParanoid. • CN11041 Caenorhabditis brenneri (small nematode) CN13105 Caenorhabditis brenneri (small nematode) CN13922 Caenorhabditis brenneri (small nematode) CN18738 Caenorhabditis brenneri (small nematode) CN20932 Caenorhabditis brenneri (small nematode) CN28973 Caenorhabditis brenneri (small nematode) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36298 modMine - Data generated by the modENCODE project. • FBgn0026176 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0231145 FBgn0223334 FBgn0207826 FBgn0197141 FBgn0197139 FBgn0175269 FBgn0081374 FBgn0154594 FBgn0143703 FBgn0128323 FBgn0114779 FBgn0089680 FBgn0088176
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG8881 (Murphy, 2003, Keleman et al., 2009.8.5) dskpB (Murphy et al., 1999) Skp (Alexandre et al., 2008) skpB (Sathyanarayanan et al., 2008, Rogers et al., 2009, Mohan et al., 2010)
Name Synonym	skpB
Secondary FlyBase IDs
	FBgn0033684
References ( 17 )
Research paper	Mohan et al., 2010, Genes Dev. 24(6): 574--589 Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). [FBrf0210203] Rogers et al., 2009, J. Cell Biol. 184(2): 225--239 The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication. [FBrf0206754] Sathyanarayanan et al., 2008, Genes Dev. 22(11): 1522--1533 Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. [FBrf0204805] Murphy, 2003, J. Cell Sci. 116(11): 2321--2332 Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation. [FBrf0159039]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Review	Ou et al., 2003, Trends Genet. 19(7): 382--389 Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. [FBrf0160832]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Abstract	Alexandre et al., 2008, A. Dros. Res. Conf. 49: 385A Investigating regulation of Armadillo protein stability in Drosophila. [FBrf0203632] Murphy et al., 1999, A. Dros. Res. Conf. 40: 682C Analysis of the roles of a family of Drosophila skp1 homologs in cell cycle progression. [FBrf0106993]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Murphy, 1999.12.29, GenBank/EMBL/DDBJ: AF220067 Drosophila melanogaster SKPB gene, complete cds. [FBrf0128008]
Curated genome annotation	Ashburner, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126651]