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Gene Dmel\siz

General Information
Symbol	Dmel\siz	Species	D. melanogaster
Name	schizo	Annotation symbol	CG32434
Feature type	protein_coding_gene	FlyBase ID	FBgn0026179
Gene Model Status	Current	Stock availability	23 publicly available
Also Known As	loner
Genomic Location
Chromosome (arm)	3L	Recombination map	3-51 +/- 3
Cytogenetic map	78A5-78B1	Sequence location	3L:21,027,635..21,068,544 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene schizo is referred to in FlyBase by the symbol Dmel\siz (CG32434, FBgn0026179). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cadherin binding. There is experimental evidence that it is involved in the biological process: myoblast fusion; central nervous system development; inter-male aggressive behavior; actin cytoskeleton organization; imaginal disc-derived wing morphogenesis. 58 alleles are reported. The phenotypes of these alleles are annotated with: commissure; ventral nerve cord commissure; midline glial cell; embryonic myoblast; fusion competent cell. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: IQ motif, EF-hand binding site; Pleckstrin homology domain; Pleckstrin homology-like domain; SEC7-like; SEC7-like, alpha orthogonal bundle. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Gene sequence location is 3L:21027635..21068544.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms nucleus cell junction trans-Golgi network vesicle-mediated transport
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 78A5-78B1   Limits computationally determined from genome sequence between P{EP}fngEP3082&P{lacW}skdL7062 and P{lacW}l(3)L5541L5541
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-51 +/- 3 (Hummel et al., 1999)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\siz for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) siz-RA FBtr0078290  NM_206407   5314   1313 siz-RB FBtr0078289  NM_168881   5130   1325 siz-RC FBtr0111038  NM_001043153   4654   1210 siz-RD FBtr0301602  NM_001170016   4931   1220
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein siz-PA   FBpp0077948   142.9   1313   9.70     NP_996129   AAS65082 siz-PB   FBpp0077947   144.0   1325   8.92     NP_730594   AAF51675 siz-PC   FBpp0110337   131.4   1210   9.39     NP_001036618   ABI31265 siz-PD   FBpp0290817   132.7   1220   9.40     NP_001163487   ACZ94758
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • IQ motif, EF-hand binding site (IPR000048) SEC7-like (IPR000904) Pleckstrin homology-like domain (IPR011993) Pleckstrin homology domain (IPR001849) SEC7-like, alpha orthogonal bundle (IPR023394)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696824   AE014296 AAF51675   AE014296 AAS65082   AE014296 ABI31265   AE014296 ACZ94758   AI133851   AI238782   AI258331   AI512816   AW941752   AY058333 AAL13562   AY375488 AAQ75367   AY375489 AAQ75368   BF497107   BI163213   BI165504   BI357926   BT003600   BT016033 AAV36918   BT016080 AAV36965   CL632196   CO177597   CO177936   CO182687   CO185227   CO185302   CO190184   CO263979   CO268772   CO268796   CO278199   CO282370   CO282416   CO285063   CO291866   CO300576   CO314404   CO315208   CO316002   CO325715   CO331025   CO334047   CO335972   CO339335   CO339591   CO344287   CZ467374   CZ470612   CZ474187   CZ476175   CZ477676   CZ479199   CZ480497   CZ481181   CZ481427   CZ487171   CZ487494   DU708602   EC060281   EC063495   EC066449   EC069743   EC073232   EC073339   EC073543   EC074181   EC078502   EC081020   EC082525   EC084955   EC197172   EC199846   EC200036   EC205871   EC206934   EC209714   EC212365   EC214063   EC227304   EC239925   EC244434   EC245192   EC253014   EC255322   EC257848   EC257912   EC265033
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q6U9V3 Q7KTX2 Q9VP80 E1JI59 Q95U36 Q5U159 Q5U112
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435169 3L:21,059,048..21,060,941 evidence=Reporter construct (in vivo) (Reeves and Posakony, 2005, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   central brain anlage in statu nascendi   (Fisher et al., 2012) dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi organism | gap expression pattern   (Fisher et al., 2012) ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi visual anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi antennal anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi dorsal head epidermis anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal ectoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic neuroblast of ventral nerve cord primordium   (Fisher et al., 2012) embryonic optic lobe primordium   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) procephalic neuroblast   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    32 central nervous system, pupae P8    33 head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    19 head, mated 1-day female    20 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male    34 head, mated 4-day male    32 head, mated 20-day male    32 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    13 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    28 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    18 ovary, virgin 4-day female    20 ovary, mated 4-day female    17 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3  (32) central nervous system, pupae P8  (33) head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    19 head, mated 1-day female    20 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male  (34) head, mated 4-day male  (32) head, mated 20-day male  (32) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (63) digestive system, larvae L3 wandering    21 digestive system, 1-day adult    13 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering  (28) carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    18 ovary, virgin 4-day female    20 ovary, mated 4-day female    17 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    32 central nervous system, pupae P8    33 head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    19 head, mated 1-day female    20 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male    34 head, mated 4-day male    32 head, mated 20-day male    32 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    13 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    28 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    18 ovary, virgin 4-day female    20 ovary, mated 4-day female    17 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    32 central nervous system, pupae P8    33 head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    19 head, mated 1-day female    20 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male    34 head, mated 4-day male    32 head, mated 20-day male    32 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    13 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    28 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    18 ovary, virgin 4-day female    20 ovary, mated 4-day female    17 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    32 central nervous system, pupae P8    33 head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    19 head, mated 1-day female    20 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male    34 head, mated 4-day male    32 head, mated 20-day male    32 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    13 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    28 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    18 ovary, virgin 4-day female    20 ovary, mated 4-day female    17 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3  32 central nervous system, pupae P8  (33) head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    19 head, mated 1-day female    20 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male  (34) head, mated 4-day male  32 head, mated 20-day male  32 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (63) digestive system, larvae L3 wandering    21 digestive system, 1-day adult    13 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering  28 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    18 ovary, virgin 4-day female    20 ovary, mated 4-day female    17 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    32 central nervous system, pupae P8    33 head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    19 head, mated 1-day female    20 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male    34 head, mated 4-day male    32 head, mated 20-day male    32 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    13 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    28 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    18 ovary, virgin 4-day female    20 ovary, mated 4-day female    17 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    32 central nervous system, pupae P8    33 head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    19 head, mated 1-day female    20 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male    34 head, mated 4-day male    32 head, mated 20-day male    32 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    13 digestive system, 4-day adult    17 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    12 carcass, larvae L3 wandering    28 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    18 ovary, virgin 4-day female    20 ovary, mated 4-day female    17 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    40 embryo 04-06hr    59 embryo 06-08hr    54 embryo 08-10hr    32 embryo 10-12hr    24 embryo 12-14hr    25 embryo 14-16hr    37 embryo 16-18hr    34 embryo 18-20hr    32 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    12 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    27 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    16 pupae 4d postWPP    21 adult male 01day    19 adult male 05day    23 adult male 30day    23 adult female 01day    17 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr  (40) embryo 04-06hr  (59) embryo 06-08hr  (54) embryo 08-10hr  (32) embryo 10-12hr    24 embryo 12-14hr    25 embryo 14-16hr  (37) embryo 16-18hr  (34) embryo 18-20hr  (32) embryo 20-22hr    21 embryo 22-24hr    21 larva L1    12 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  (27) white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    16 pupae 4d postWPP    21 adult male 01day    19 adult male 05day    23 adult male 30day    23 adult female 01day    17 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    40 embryo 04-06hr    59 embryo 06-08hr    54 embryo 08-10hr    32 embryo 10-12hr    24 embryo 12-14hr    25 embryo 14-16hr    37 embryo 16-18hr    34 embryo 18-20hr    32 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    12 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    27 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    16 pupae 4d postWPP    21 adult male 01day    19 adult male 05day    23 adult male 30day    23 adult female 01day    17 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    40 embryo 04-06hr    59 embryo 06-08hr    54 embryo 08-10hr    32 embryo 10-12hr    24 embryo 12-14hr    25 embryo 14-16hr    37 embryo 16-18hr    34 embryo 18-20hr    32 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    12 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    27 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    16 pupae 4d postWPP    21 adult male 01day    19 adult male 05day    23 adult male 30day    23 adult female 01day    17 adult female 05day    17 adult female 30day    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    40 embryo 04-06hr    59 embryo 06-08hr    54 embryo 08-10hr    32 embryo 10-12hr    24 embryo 12-14hr    25 embryo 14-16hr    37 embryo 16-18hr    34 embryo 18-20hr    32 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    12 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    27 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    16 pupae 4d postWPP    21 adult male 01day    19 adult male 05day    23 adult male 30day    23 adult female 01day    17 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr  (40) embryo 04-06hr  (59) embryo 06-08hr  (54) embryo 08-10hr  32 embryo 10-12hr    24 embryo 12-14hr    25 embryo 14-16hr  (37) embryo 16-18hr  (34) embryo 18-20hr  32 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    12 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  27 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    16 pupae 4d postWPP    21 adult male 01day    19 adult male 05day    23 adult male 30day    23 adult female 01day    17 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    40 embryo 04-06hr    59 embryo 06-08hr    54 embryo 08-10hr    32 embryo 10-12hr    24 embryo 12-14hr    25 embryo 14-16hr    37 embryo 16-18hr    34 embryo 18-20hr    32 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    12 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    27 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    16 pupae 4d postWPP    21 adult male 01day    19 adult male 05day    23 adult male 30day    23 adult female 01day    17 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    40 embryo 04-06hr    59 embryo 06-08hr    54 embryo 08-10hr    32 embryo 10-12hr    24 embryo 12-14hr    25 embryo 14-16hr    37 embryo 16-18hr    34 embryo 18-20hr    32 embryo 20-22hr    21 embryo 22-24hr    21 larva L1    12 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    27 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    16 pupae 4d postWPP    21 adult male 01day    19 adult male 05day    23 adult male 30day    23 adult female 01day    17 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    15 embryonic Kc167    7 embryonic S1    9 embryonic S3    24 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    2 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    19 ovary fGS/OSS    5 ovary OSC    4 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    15 embryonic Kc167    7 embryonic S1    9 embryonic S3    24 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    2 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    19 ovary fGS/OSS    5 ovary OSC    4 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    15 embryonic Kc167    7 embryonic S1    9 embryonic S3    24 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    2 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    19 ovary fGS/OSS    5 ovary OSC    4 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    15 embryonic Kc167    7 embryonic S1    9 embryonic S3    24 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    2 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    19 ovary fGS/OSS    5 ovary OSC    4 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    15 embryonic Kc167    7 embryonic S1    9 embryonic S3    24 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    2 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    19 ovary fGS/OSS    5 ovary OSC    4 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    15 embryonic Kc167    7 embryonic S1    9 embryonic S3    24 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    2 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    19 ovary fGS/OSS    5 ovary OSC    4 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    15 embryonic Kc167    7 embryonic S1    9 embryonic S3    24 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    2 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    19 ovary fGS/OSS    5 ovary OSC    4 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    15 embryonic Kc167    7 embryonic S1    9 embryonic S3    24 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    2 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    21 tumorous blood cells mbn2    19 ovary fGS/OSS    5 ovary OSC    4 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_31 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GH10594 RE02556 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026179 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32434-RB;CT32172 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for siz Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal sizCB03288 sizl(3)3 viable sizLA00033 viable, with Scer\GAL4pnr-MD237 sizGD14895 Sterility Allele fertile sizLA00033 Other Phenotypes Allele behavior defective | recessive sizBG00735 Phenotype manifest in Allele commissure sizU112 embryonic myoblast sizC1-28 sizT1032 sizU112 embryonic myoblast (with sizC1-28) sizU112 embryonic myoblast (with sizU112) sizC1-28 fusion competent cell sizT1032 longitudinal connective | embryonic stage sizU112 midline glial cell sizU112 ventral nerve cord commissure sizC1-28 sizP224 sizU112 sizl(3)3 ventral nerve cord commissure | embryonic stage sizU112
Classical Alleles ( 34 )
For All Classical Alleles Show
Allele of siz Class Mutagen Stocks Known lesion sizKG08286 2 -- sizc01067 1 -- sizc01699 piggyBac transposase 1 -- sizc06339 piggyBac transposase 1 -- sizd04881 P-element activity 1 -- sizd08140 1 -- sizd11324 P-element activity 1 -- size01391 piggyBac transposase 1 -- size02726 piggyBac transposase 1 -- size03674 piggyBac transposase 1 -- sizEY09677 P-element activity 1 -- sizf04631 piggyBac transposase 1 -- sizf04908 piggyBac transposase 1 -- sizLA00033 P-element activity 1 -- sizMI01727 1 -- sizMI02011 1 -- sizMI05049 1 -- sizNP4792 1 -- sizT1032 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes sizT2057 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes siz3 hypomorphic allele - genetic evidence 0 -- sizBG00735 0 -- sizC1-28 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- sizCB03288 P-element activity 0 Yes sizCPTI004536 piggyBac transposase 0 Yes sizd08318 P-element activity 0 -- sizDG12601 P-element activity 0 -- size03405 piggyBac transposase 0 -- sizl(3)3 P-element activity 0 Yes sizP224 P-element activity 0 Yes sizT1015 0 -- sizT1510 0 -- sizU112 loss of function allele ethyl methanesulfonate 0 -- sizunspecified 0 --
Alleles Carried on Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Allele of siz Class Mutagen Stocks Known lesion sizGD14895 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes sizHMS01980 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sizKK103616 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes siz1-759.Scer\UAS.T:Hsap\MYC,T:Avic\GFP-VC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes siziso1.Act5C in vitro construct - regulatory fusion 0 Yes siziso1.E->K.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes siziso1.E->K.Tub in vitro construct - site directed mutagenesis 0 Yes siziso1.Scer\UAS in vitro construct - regulatory fusion 0 Yes siziso1.Tub in vitro construct - regulatory fusion 0 Yes siziso1.ΔIQ.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes siziso1.ΔIQ.Tub in vitro construct - site directed mutagenesis 0 Yes siziso1.ΔPH.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes siziso1.ΔPH.Tub in vitro construct - site directed mutagenesis 0 Yes siziso1.ΔSec7.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes siziso1.ΔSec7.Tub in vitro construct - site directed mutagenesis 0 Yes siziso2.Act5C in vitro construct - regulatory fusion 0 Yes siziso2.Scer\UAS in vitro construct - regulatory fusion 0 Yes siziso2.Tub in vitro construct - regulatory fusion 0 Yes siziso3.Act5C in vitro construct - regulatory fusion 0 Yes siziso3.Scer\UAS in vitro construct - regulatory fusion 0 Yes siziso3.Tub in vitro construct - regulatory fusion 0 Yes sizP1.Scer\UAS in vitro construct - regulatory fusion 0 Yes sizP2.Scer\UAS in vitro construct - regulatory fusion 0 Yes sizScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)ME107 (Chen et al., 2003) Df(3L)Pc-MK (Chen et al., 2003)
Not disrupted in	Df(3L)Pc-cp2 (Chen et al., 2003) Df(3L)ri-XT1 (Chen et al., 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14895} NA P{KK103616} NA P{TRiP.HMS01980} NA P{UAS-loner.iso1.E->K} NA P{UAS-loner.iso1.ΔIQ} NA P{UAS-loner.iso1.ΔPH} NA P{UAS-loner.iso1.ΔSec7} NA P{UAS-loner.iso1} NA P{UAS-loner.iso2} NA P{UAS-loner.iso3} NA P{UAS-siz.HA} NA P{UAS-siz.P1} NA P{UAS-siz.P2} NA P{UAS-siz-C-YFP.1-759} NA characterization construct P{Act5C-loner.iso1} NA P{Act5C-loner.iso2} NA P{Act5C-loner.iso3} NA P{Tub-loner.iso1.E->K} NA P{Tub-loner.iso1.ΔIQ} NA P{Tub-loner.iso1.ΔPH} NA P{Tub-loner.iso1.ΔSec7} NA P{Tub-loner.iso1} NA P{Tub-loner.iso2} NA P{Tub-loner.iso3} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}sizEY09677 NA P{Mae-UAS.6.11}sizLA00033 NA P{XP}sizd04881 NA P{XP}sizd08140 NA P{XP}sizd08318 NA P{XP}sizd11324 NA miscellaneous insertions Mi{MIC}sizMI01727 NA Mi{MIC}sizMI02011 NA Mi{MIC}sizMI05049 NA P{}sizl(3)3 NA P{}sizP224 NA P{GT1}sizBG00735 NA P{PTT-GB}sizCB03288 NA P{SUPor-P}sizKG08286 NA P{wHy}sizDG12601 NA PBac{810.P.FSVS-2}sizCPTI004536 NA PBac{PB}sizc01067 NA PBac{PB}sizc01699 NA PBac{PB}sizc06339 NA PBac{RB}size01391 NA PBac{RB}size02726 NA PBac{RB}size03405 NA PBac{RB}size03674 NA PBac{WH}sizf04631 NA PBac{WH}sizf04908 NA insertion of enhancer trap binary system P{GawB}sizNP4792 No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
cadherin binding inferred from direct assay (Dottermusch-Heidel et al., 2012)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (Richardson et al., 2007) central nervous system development inferred from mutant phenotype (Hummel et al., 1999) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Carreira et al., 2011) inter-male aggressive behavior inferred from mutant phenotype (Edwards et al., 2009) myoblast fusion inferred from mutant phenotype (Chen et al., 2003, Richardson et al., 2007, Bulchand et al., 2010, Dottermusch-Heidel et al., 2012)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
ARF guanyl-nucleotide exchange factor activity inferred from biological aspect of ancestor with PANTHER:PTN000070561 (assigned by RefGenome) (Gaudet et al., 2010) guanyl-nucleotide exchange factor activity inferred from sequence or structural similarity with UniProtKB:Q9LZX8 (FlyBase Genome Annotators, 2002-2003) non-traceable author statement (Chen, 2003.8.27) phospholipid binding inferred from electronic annotation with InterPro:IPR001849 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
myoblast fusion non-traceable author statement (Chen, 2003.8.27) regulation of ARF protein signal transduction inferred from electronic annotation with InterPro:IPR000904 (FlyBase Curators et al., 2004-) NOT vesicle-mediated transport inferred from biological aspect of ancestor with PANTHER:PTN000070822 (assigned by RefGenome) (Gaudet et al., 2010)
Cellular Component
CV term Evidence References
cell junction inferred from biological aspect of ancestor with PANTHER:PTN000070822 (assigned by RefGenome) (Gaudet et al., 2010) nucleus inferred from biological aspect of ancestor with PANTHER:PTN000070822 (assigned by RefGenome) (Gaudet et al., 2010) NOT trans-Golgi network inferred from biological aspect of ancestor with PANTHER:PTN000070822 (assigned by RefGenome) (Gaudet et al., 2010)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
siz - dock anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions siz allele Gene References sizP1.Scer\UAS sli (Onel et al., 2004) sizP2.Scer\UAS sli (Onel et al., 2004) sizU112 fra (Hummel et al., 1999) sli (Onel et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65580 DroID - A comprehensive database of gene and protein interactions. • FBgn0026179 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40327
Orthologs
OrthoDB Orthologs (54) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6H72X8 Dipteran inclusive ortholog search EOG6WSWJX Insect inclusive ortholog search EOG698SVS Arthropod inclusive ortholog search EOG6H189S Metazoa inclusive ortholog search EOG6W71P8
Orthologs in Drosophila Species (EOG6H72X8)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\siz     Drosophila simulans   Dsim\GD14932     Drosophila sechellia   Dsec\GM22340     Drosophila erecta   Dere\GG16158     Drosophila yakuba   Dyak\GE19727     Drosophila yakuba   Dyak\GE19726     Drosophila ananassae   Dana\GF24294 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA23806     Drosophila pseudoobscura pseudoobscura   Dpse\GA27823     Drosophila persimilis   Dper\GL26865     Drosophila persimilis   Dper\GL22422     Drosophila willistoni   Dwil\GK25417 Y   Drosophila virilis   Dvir\GJ11748     Drosophila mojavensis   Dmoj\GI13893 Y   Drosophila grimshawi   Dgri\GH14566 Y
Orthologs in non-Drosophila Dipterans (EOG6WSWJX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000906   Anopheles gambiae Malaria mosquito  Agam\AGAP011421   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002812
Orthologs in non-Dipteran Insects (EOG698SVS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46262   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004818   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11658   Atta cephalotes Leafcutter ant  Acep\ACEP18929   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13070   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16840   Linepithema humile Argentine ant  Lhum\LH13058   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24117   Solenopsis invicta Red fire ant  Sinv\SINV17769   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003771   Bombyx mori Silkmoth  Bmor\BGIBMGA004600   Pediculus humanus Human body louse  Phum\PHUM029790   Tribolium castaneum Red flour beetle  Tcas\TC005167
Orthologs in non-Insect Arthropods (EOG6H189S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_31197   Ixodes scapularis Deer tick  Isca\ISCW004849
Orthologs in non-Arthropod Metazoa (EOG6W71P8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\M02B7.5   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008687gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003044gn   Danio rerio Zebrafish  Drer\ENSDARG00000073822   Danio rerio Zebrafish  Drer\si:ch211-15l13.1   Danio rerio Zebrafish  Drer\CR847934.1   Danio rerio Zebrafish  Drer\si:ch211-11f8.2   Danio rerio Zebrafish  Drer\si:ch211-218o21.3   Xenopus tropicalis Western clawed frog  Xtro\iqsec1   Xenopus tropicalis Western clawed frog  Xtro\iqsec2   Xenopus tropicalis Western clawed frog  Xtro\iqsec3   Gallus gallus Domestic chicken  Ggal\IQSEC1   Gallus gallus Domestic chicken  Ggal\IQSEC3   Mus musculus House mouse  Mmus\Iqsec1   Mus musculus House mouse  Mmus\Iqsec2   Mus musculus House mouse  Mmus\Iqsec3   Rattus norvegicus Norway rat  Rnor\Iqsec3   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000003466   Homo sapiens Human  Hsap\IQSEC1   Homo sapiens Human  Hsap\ENSG00000124313   Homo sapiens Human  Hsap\IQSEC3
Human Orthologs (3)
Gene OMIM HGNC Hsap\IQSEC1     Hsap\ENSG00000124313     Hsap\IQSEC3
AAA Orthologs (4) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila ananassae Dana\GF24294 Drosophila willistoni Dwil\GK25417 Drosophila mojavensis Dmoj\GI13893 Drosophila grimshawi Dgri\GH14566
Stocks & Reagents
Stocks Listed in FlyBase ( 23 )
Harvard	- P{XP}sizd04881 - P{XP}sizd08140 - P{XP}sizd11324 - PBac{PB}sizc01067 - PBac{PB}sizc01699 - PBac{PB}sizc06339 - PBac{RB}size01391 - PBac{RB}size02726 - PBac{RB}size03674 - PBac{WH}sizf04631 - PBac{WH}sizf04908
VDRC	v106168 P{KK103616}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR03J02 BACR24H03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 64 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10594 GM06994 LP01489 RE02556
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT11181 GH14890 GM08468 LD44876 RE05422 RE44556
Other clones	5818 17219 29105 39183 39976 41469 43795 44932 52644 55048 57662 70140 70619 107881 160290 173957 175301 214407.7 214439.64 214447.51 214531.43 283145 542910 CK01.3D.D11 CK01.58B.F1 CK01.66B.H4 CK01.68B.A4 CK01.121A.B6 CK01.121B.C8 EC23665 EC29965 EK007816 EK046921 EK053862 EK054734 EK092639 EK092744 EK129321 EK137050 EK160322 EK160426 EK168122 EK178626 EK197317 EK198543 EK236033 EK239706 EK263320 EK297305 EK308742 EN11563 EP01634 EP02327 EP19007
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026179 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40327
Antibody Information
Other Information
Discoverer
Etymology
	"schizo" means "split" in German. (Hummel et al., 1999)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: loner CG32434 (FlyBase, 1996-)
Source for database merge of	Source for merge of: CG10577 CG12980 CG12981 (FlyBase Genome Annotators, 2002-2003) Source for merge of: siz loner (Onel et al., 2004)
Additional comments	Annotations CG10577, CG12980 and CG12981 merged as CG32434 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for identity of loner CG32434 was sequence comparison (date:031005). (FlyBase, 1996-)
Other Comments
	Two EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo. (Hummel et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_168881 NM_206407 NM_001043153 NM_001170016 RefSeq (Proteins) • NP_730594 NP_996129 NP_001036618 NP_001163487 DDBJ / EMBL / GenBank • AAF51675 AAL13562 AAQ75367 AAQ75368 AAS65082 AAV36918 AAV36965 ABI31265 ACZ94758 AI133851 AI258331 AW941752 AY058333 AY375488 AY375489 BI163213 BT016033 BT016080 CL632196 CZ467374 CZ470612 CZ474187 CZ476175 CZ477676 CZ479199 CZ480497 CZ481181 CZ481427 CZ487171 CZ487494 DU708602 Entrez Gene - A searchable database of RefSeq genes. • 40327 UniProtKB/TrEMBL • E1JI59 Q5U112 Q5U159 Q6U9V3 Q7KTX2 Q9VP80 Q95U36
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • IQ motif, EF-hand binding site (IPR000048) SEC7-like (IPR000904) Pleckstrin homology-like domain (IPR011993) Pleckstrin homology domain (IPR001849) SEC7-like, alpha orthogonal bundle (IPR023394) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH10594 RE02556
Linkouts
	BioGRID - A database of protein and genetic interactions • 65580 DroID - A comprehensive database of gene and protein interactions. • FBgn0026179 DRSC - Results from RNAi screens. • FBgn0026179 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026179 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32434-RB;CT32172 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026179 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40327 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40327 modMine - Data generated by the modENCODE project. • FBgn0026179 REDfly - A database of transcriptional regulatory elements. • FBgn0026179
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG10577 (Brody et al., 2002, ) CG12980   CG12981   CG32434 (Cox et al., 2004, Milchanowski et al., 2004, Onel et al., 2004, Matyash et al., 2004, Giot et al., 2003, Lawniczak and Begun, 2004, Keleman et al., 2009.8.5, Gupta et al., 2009, Morozova et al., 2006, Aerts et al., 2010, Ni et al., 2010.12.1) loner (Donaldson, 2003, Chen and Olson, 2004, Chen et al., 2003, Richardson and Baylies, 2005, Taylor, 2003, FlyBase, 1996-, Reeves and Posakony, 2005, Rochlin et al., 2007, Richardson et al., 2007, Wang et al., 2012) Loner (Chen et al., 2007) schizo (Wang et al., 2012) siz (Buszczak et al., 2007, Dottermusch-Heidel et al., 2012, Johnson et al., 2011, Aerts et al., 2010, Carreira et al., 2011)
Name Synonym	dBRAG (Casanova, 2007) loner (Beckett and Baylies, 2007, Bulchand et al., 2010) Loner (Casanova, 2007) schizo (Hummel et al., 1999, Dottermusch-Heidel et al., 2012, Raghu et al., 2009, Gupta et al., 2009, Edwards et al., 2009, Edwards et al., 2009, Casanova, 2007) Schizo (Johnson et al., 2011)
Secondary FlyBase IDs
	FBgn0037047 FBgn0037048 FBgn0037049 FBgn0052434
References ( 66 )
Generate a list of	All references relating to this gene ( 66 )
List References by type	Research paper  ( 25 ) Supplementary material  ( 5 ) Review  ( 7 ) Personal communication to FlyBase  ( 17 ) Abstract  ( 4 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 1 ) Website  ( 2 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	Dottermusch-Heidel et al., 2012, Dev. Biol. 368(1): 18--27 The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts. [FBrf0218661] Wang et al., 2012, J. Cell Sci. 125(2): 461--472 GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis. [FBrf0217573] Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Johnson et al., 2011, Mol. Biol. Cell 22(23): 4513--4526 Role for a Cindr-Arf6 axis in patterning emerging epithelia. [FBrf0216708] Zwarts et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(41): 17070--17075 Complex genetic architecture of Drosophila aggressive behavior. [FBrf0216413] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...