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Gene Dmel\siz

General Information
Symbol	Dmel\siz	Species	D. melanogaster
Name	schizo	Annotation symbol	CG32434
Feature type	protein_coding_gene	FlyBase ID	FBgn0026179
Gene Model Status	Current	Stock availability	21 publicly available
Also Known As	loner
Genomic Location
Chromosome (arm)	3L	Recombination map	3-51 +/- 3
Cytogenetic map	78A5-78B1	Sequence location	3L:21,027,639..21,068,544 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene schizo is referred to in FlyBase by the symbol Dmel\siz (CG32434, FBgn0026179). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process: myoblast fusion; central nervous system development; inter-male aggressive behavior; actin cytoskeleton organization. 52 alleles are reported. The phenotypes of these alleles are annotated with: commissure; ventral nerve cord commissure; midline glial cell; embryonic myoblast. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: IQ motif, EF-hand binding site; Pleckstrin homology domain; Pleckstrin homology-type; SEC7-like; SEC7-like, alpha orthogonal bundle. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Gene sequence location is 3L:21027639..21068544.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	References Carreira et al., 2011, BMC Dev. Biol. 11: 32 Zwarts et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(41): 17070--17075 Sequence features HFA11690 HFA11689 BKN23808 HFA11622
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 78A5-78B1   Limits computationally determined from genome sequence between P{EP}fngEP3082&P{lacW}skdL7062 and P{lacW}l(3)L5541L5541
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-51 +/- 3 (Hummel et al., 1999)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\siz for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) siz-RA FBtr0078290  NM_206407   5314   1313 siz-RB FBtr0078289  NM_168881   5126   1325 siz-RC FBtr0111038  NM_001043153   4654   1210 siz-RD FBtr0301602  NM_001170016   4931   1220
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein siz-PA   FBpp0077948   142.9   1313   9.70     NP_996129   AAS65082 siz-PB   FBpp0077947   144.0   1325   8.92     NP_730594   AAF51675 siz-PC   FBpp0110337   131.4   1210   9.39     NP_001036618   ABI31265 siz-PD   FBpp0290817   132.7   1220   9.40     NP_001163487   ACZ94758
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • IQ motif, EF-hand binding site (IPR000048) SEC7-like (IPR000904) Pleckstrin homology-type (IPR011993) Pleckstrin homology domain (IPR001849) SEC7-like, alpha orthogonal bundle (IPR023394)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696824   AE014296 AAF51675   AE014296 AAS65082   AE014296 ABI31265   AE014296 ACZ94758   AI133851   AI238782   AI258331   AI512816   AW941752   AY058333 AAL13562   AY375488 AAQ75367   AY375489 AAQ75368   BF497107   BI163213   BI165504   BI357926   BT003600   BT016033 AAV36918   BT016080 AAV36965   CL632196   CO177597   CO177936   CO182687   CO185227   CO185302   CO190184   CO263979   CO268772   CO268796   CO278199   CO282370   CO282416   CO285063   CO291866   CO300576   CO314404   CO315208   CO316002   CO325715   CO331025   CO334047   CO335972   CO339335   CO339591   CO344287   CZ467374   CZ470612   CZ474187   CZ476175   CZ477676   CZ479199   CZ480497   CZ481181   CZ481427   CZ487171   CZ487494   DU708602   EC060281   EC063495   EC066449   EC069743   EC073232   EC073339   EC073543   EC074181   EC078502   EC081020   EC082525   EC084955   EC197172   EC199846   EC200036   EC205871   EC206934   EC209714   EC212365   EC214063   EC227304   EC239925   EC244434   EC245192   EC253014   EC255322   EC257848   EC257912   EC265033
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q5U112 Q5U159 Q6U9V3 Q7KTX2 Q95U36 Q9VP80 E1JI59
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0026179    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0026179 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0026179 expression level Developmental Stage   Expression Level embryo 00-02hr    1888 embryo 02-04hr    3006 embryo 04-06hr    4485 embryo 06-08hr    4128 embryo 08-10hr    2457 embryo 10-12hr    1859 embryo 12-14hr    1878 embryo 14-16hr    2806 embryo 16-18hr    2619 embryo 18-20hr    2467 embryo 20-22hr    1621 embryo 22-24hr    1574 larva L1    943 larva L2    994 larva L3 12hr old    770 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1654 larva L3 puffstage 7-9    2026 white prepupae new    1766 white prepupae 12hr    1395 white prepupae 24hr    1232 pupae 2d postWPP    1541 pupae 3d postWPP    1193 pupae 4d postWPP    1631 adult male 01day    1423 adult male 05day    1723 adult male 30day    1771 adult female 01day    1291 adult female 05day    1274 adult female 30day    1379 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1888) embryo 02-04hr  (3006) embryo 04-06hr  (4485) embryo 06-08hr  (4128) embryo 08-10hr  (2457) embryo 10-12hr  (1859) embryo 12-14hr  (1878) embryo 14-16hr  (2806) embryo 16-18hr  (2619) embryo 18-20hr  (2467) embryo 20-22hr  (1621) embryo 22-24hr  (1574) larva L1  (943) larva L2  (994) larva L3 12hr old  (770) larva L3 puffstage 1-2  (751) larva L3 puffstage 3-6  (1654) larva L3 puffstage 7-9  (2026) white prepupae new  (1766) white prepupae 12hr  (1395) white prepupae 24hr  (1232) pupae 2d postWPP  (1541) pupae 3d postWPP  (1193) pupae 4d postWPP  (1631) adult male 01day  (1423) adult male 05day  (1723) adult male 30day  (1771) adult female 01day  (1291) adult female 05day  (1274) adult female 30day  (1379) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1888) embryo 02-04hr  (3006) embryo 04-06hr  (4485) embryo 06-08hr  (4128) embryo 08-10hr  (2457) embryo 10-12hr  (1859) embryo 12-14hr  (1878) embryo 14-16hr  (2806) embryo 16-18hr  (2619) embryo 18-20hr  (2467) embryo 20-22hr  (1621) embryo 22-24hr  (1574) larva L1    943 larva L2    994 larva L3 12hr old    770 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6  (1654) larva L3 puffstage 7-9  (2026) white prepupae new  (1766) white prepupae 12hr    1395 white prepupae 24hr    1232 pupae 2d postWPP  (1541) pupae 3d postWPP    1193 pupae 4d postWPP  (1631) adult male 01day  1423 adult male 05day  (1723) adult male 30day  (1771) adult female 01day    1291 adult female 05day    1274 adult female 30day    1379 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1888 embryo 02-04hr    3006 embryo 04-06hr    4485 embryo 06-08hr    4128 embryo 08-10hr    2457 embryo 10-12hr    1859 embryo 12-14hr    1878 embryo 14-16hr    2806 embryo 16-18hr    2619 embryo 18-20hr    2467 embryo 20-22hr    1621 embryo 22-24hr    1574 larva L1    943 larva L2    994 larva L3 12hr old    770 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1654 larva L3 puffstage 7-9    2026 white prepupae new    1766 white prepupae 12hr    1395 white prepupae 24hr    1232 pupae 2d postWPP    1541 pupae 3d postWPP    1193 pupae 4d postWPP    1631 adult male 01day    1423 adult male 05day    1723 adult male 30day    1771 adult female 01day    1291 adult female 05day    1274 adult female 30day    1379 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1888 embryo 02-04hr    3006 embryo 04-06hr    4485 embryo 06-08hr    4128 embryo 08-10hr    2457 embryo 10-12hr    1859 embryo 12-14hr    1878 embryo 14-16hr    2806 embryo 16-18hr    2619 embryo 18-20hr    2467 embryo 20-22hr    1621 embryo 22-24hr    1574 larva L1    943 larva L2    994 larva L3 12hr old    770 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1654 larva L3 puffstage 7-9    2026 white prepupae new    1766 white prepupae 12hr    1395 white prepupae 24hr    1232 pupae 2d postWPP    1541 pupae 3d postWPP    1193 pupae 4d postWPP    1631 adult male 01day    1423 adult male 05day    1723 adult male 30day    1771 adult female 01day    1291 adult female 05day    1274 adult female 30day    1379 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0026179 expression level Developmental Stage   Expression Level embryo 00-02hr    1888 embryo 02-04hr    3006 embryo 04-06hr    4485 embryo 06-08hr    4128 embryo 08-10hr    2457 embryo 10-12hr    1859 embryo 12-14hr    1878 embryo 14-16hr    2806 embryo 16-18hr    2619 embryo 18-20hr    2467 embryo 20-22hr    1621 embryo 22-24hr    1574 larva L1    943 larva L2    994 larva L3 12hr old    770 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1654 larva L3 puffstage 7-9    2026 white prepupae new    1766 white prepupae 12hr    1395 white prepupae 24hr    1232 pupae 2d postWPP    1541 pupae 3d postWPP    1193 pupae 4d postWPP    1631 adult male 01day    1423 adult male 05day    1723 adult male 30day    1771 adult female 01day    1291 adult female 05day    1274 adult female 30day    1379 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1888) embryo 02-04hr  (3006) embryo 04-06hr  (4485) embryo 06-08hr  (4128) embryo 08-10hr  (2457) embryo 10-12hr  (1859) embryo 12-14hr  (1878) embryo 14-16hr  (2806) embryo 16-18hr  (2619) embryo 18-20hr  (2467) embryo 20-22hr  (1621) embryo 22-24hr  (1574) larva L1  (943) larva L2  (994) larva L3 12hr old  (770) larva L3 puffstage 1-2  (751) larva L3 puffstage 3-6  (1654) larva L3 puffstage 7-9  (2026) white prepupae new  (1766) white prepupae 12hr  (1395) white prepupae 24hr  (1232) pupae 2d postWPP  (1541) pupae 3d postWPP  (1193) pupae 4d postWPP  (1631) adult male 01day  (1423) adult male 05day  (1723) adult male 30day  (1771) adult female 01day  (1291) adult female 05day  (1274) adult female 30day  (1379) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1888 embryo 02-04hr  (3006) embryo 04-06hr  (4485) embryo 06-08hr  (4128) embryo 08-10hr  2457 embryo 10-12hr  1859 embryo 12-14hr  1878 embryo 14-16hr  (2806) embryo 16-18hr  (2619) embryo 18-20hr  2467 embryo 20-22hr  1621 embryo 22-24hr  1574 larva L1    943 larva L2    994 larva L3 12hr old    770 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6  1654 larva L3 puffstage 7-9  2026 white prepupae new  1766 white prepupae 12hr    1395 white prepupae 24hr    1232 pupae 2d postWPP  1541 pupae 3d postWPP    1193 pupae 4d postWPP  1631 adult male 01day  1423 adult male 05day  1723 adult male 30day  1771 adult female 01day    1291 adult female 05day    1274 adult female 30day    1379 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1888 embryo 02-04hr    3006 embryo 04-06hr    4485 embryo 06-08hr    4128 embryo 08-10hr    2457 embryo 10-12hr    1859 embryo 12-14hr    1878 embryo 14-16hr    2806 embryo 16-18hr    2619 embryo 18-20hr    2467 embryo 20-22hr    1621 embryo 22-24hr    1574 larva L1    943 larva L2    994 larva L3 12hr old    770 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1654 larva L3 puffstage 7-9    2026 white prepupae new    1766 white prepupae 12hr    1395 white prepupae 24hr    1232 pupae 2d postWPP    1541 pupae 3d postWPP    1193 pupae 4d postWPP    1631 adult male 01day    1423 adult male 05day    1723 adult male 30day    1771 adult female 01day    1291 adult female 05day    1274 adult female 30day    1379 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1888 embryo 02-04hr    3006 embryo 04-06hr    4485 embryo 06-08hr    4128 embryo 08-10hr    2457 embryo 10-12hr    1859 embryo 12-14hr    1878 embryo 14-16hr    2806 embryo 16-18hr    2619 embryo 18-20hr    2467 embryo 20-22hr    1621 embryo 22-24hr    1574 larva L1    943 larva L2    994 larva L3 12hr old    770 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1654 larva L3 puffstage 7-9    2026 white prepupae new    1766 white prepupae 12hr    1395 white prepupae 24hr    1232 pupae 2d postWPP    1541 pupae 3d postWPP    1193 pupae 4d postWPP    1631 adult male 01day    1423 adult male 05day    1723 adult male 30day    1771 adult female 01day    1291 adult female 05day    1274 adult female 30day    1379 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0026179    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0026179 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026179 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32434-RB;CT32172 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for siz Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal sizCB03288 sizl(3)3 viable sizLA00033 viable, with Scer\GAL4pnr-MD237 sizGD14895 Sterility Allele fertile sizLA00033 Other Phenotypes Allele behavior defective | recessive sizBG00735 Phenotype manifest in Allele commissure sizU112 embryonic myoblast sizT1032 longitudinal connective | embryonic stage sizU112 midline glial cell sizU112 ventral nerve cord commissure sizC1-28 sizP224 sizU112 sizl(3)3 ventral nerve cord commissure | embryonic stage sizU112
Classical Alleles ( 31 )
For All Classical Alleles Show
Allele of siz Class Mutagen Stocks Known lesion sizKG08286 2 -- sizc01067 1 -- sizc01699 piggyBac transposase 1 -- sizc06339 piggyBac transposase 1 -- sizd04881 P-element activity 1 -- sizd08140 1 -- sizd11324 P-element activity 1 -- sizDG12601 P-element activity 1 -- size01391 piggyBac transposase 1 -- size02726 piggyBac transposase 1 -- size03674 piggyBac transposase 1 -- sizEY09677 P-element activity 1 -- sizf04631 piggyBac transposase 1 -- sizf04908 piggyBac transposase 1 -- sizLA00033 P-element activity 1 -- sizMI01727 1 -- sizNP4792 1 -- sizT1032 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes sizT2057 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes siz3 hypomorphic allele - genetic evidence 0 -- sizBG00735 0 -- sizC1-28 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- sizCB03288 P-element activity 0 Yes sizCPTI004536 piggyBac transposase 0 Yes sizd08318 P-element activity 0 -- size03405 piggyBac transposase 0 -- sizl(3)3 P-element activity 0 Yes sizP224 P-element activity 0 Yes sizT1015 0 -- sizU112 loss of function allele ethyl methanesulfonate 0 -- sizunspecified 0 --
Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Allele of siz Class Mutagen Stocks Known lesion sizGD14895 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes sizKK103616 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes siziso1.Act5C in vitro construct - regulatory fusion 0 Yes siziso1.E->K.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes siziso1.E->K.Tub in vitro construct - site directed mutagenesis 0 Yes siziso1.Scer\UAS in vitro construct - regulatory fusion 0 Yes siziso1.Tub in vitro construct - regulatory fusion 0 Yes siziso1.ΔIQ.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes siziso1.ΔIQ.Tub in vitro construct - site directed mutagenesis 0 Yes siziso1.ΔPH.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes siziso1.ΔPH.Tub in vitro construct - site directed mutagenesis 0 Yes siziso1.ΔSec7.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes siziso1.ΔSec7.Tub in vitro construct - site directed mutagenesis 0 Yes siziso2.Act5C in vitro construct - regulatory fusion 0 Yes siziso2.Scer\UAS in vitro construct - regulatory fusion 0 Yes siziso2.Tub in vitro construct - regulatory fusion 0 Yes siziso3.Act5C in vitro construct - regulatory fusion 0 Yes siziso3.Scer\UAS in vitro construct - regulatory fusion 0 Yes siziso3.Tub in vitro construct - regulatory fusion 0 Yes sizP1.Scer\UAS in vitro construct - regulatory fusion 0 Yes sizP2.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)ME107 (Chen et al., 2003) Df(3L)Pc-MK (Chen et al., 2003)
Not disrupted in	Df(3L)Pc-cp2 (Chen et al., 2003) Df(3L)ri-XT1 (Chen et al., 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14895} NA P{KK103616} NA P{UAS-loner.iso1.E->K} NA P{UAS-loner.iso1.ΔIQ} NA P{UAS-loner.iso1.ΔPH} NA P{UAS-loner.iso1.ΔSec7} NA P{UAS-loner.iso1} NA P{UAS-loner.iso2} NA P{UAS-loner.iso3} NA P{UAS-siz.P1} NA P{UAS-siz.P2} NA characterization construct P{Act5C-loner.iso1} NA P{Act5C-loner.iso2} NA P{Act5C-loner.iso3} NA P{Tub-loner.iso1.E->K} NA P{Tub-loner.iso1.ΔIQ} NA P{Tub-loner.iso1.ΔPH} NA P{Tub-loner.iso1.ΔSec7} NA P{Tub-loner.iso1} NA P{Tub-loner.iso2} NA P{Tub-loner.iso3} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}sizEY09677 NA P{Mae-UAS.6.11}sizLA00033 NA P{XP}sizd04881 NA P{XP}sizd08140 NA P{XP}sizd08318 NA P{XP}sizd11324 NA miscellaneous insertions Mi{MIC}sizMI01727 NA P{}sizl(3)3 NA P{}sizP224 NA P{GT1}sizBG00735 NA P{PTT-GB}sizCB03288 NA P{SUPor-P}sizKG08286 NA P{wHy}sizDG12601 NA PBac{810.P.FSVS-2}sizCPTI004536 NA PBac{PB}sizc01067 NA PBac{PB}sizc01699 NA PBac{PB}sizc06339 NA PBac{RB}size01391 NA PBac{RB}size02726 NA PBac{RB}size03405 NA PBac{RB}size03674 NA PBac{WH}sizf04631 NA PBac{WH}sizf04908 NA insertion of enhancer trap binary system P{GawB}sizNP4792 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (Richardson et al., 2007) central nervous system development inferred from mutant phenotype (Hummel et al., 1999) inter-male aggressive behavior inferred from mutant phenotype (Edwards et al., 2009) myoblast fusion inferred from mutant phenotype (Chen et al., 2003, Richardson et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ARF guanyl-nucleotide exchange factor activity inferred from electronic annotation with InterPro:IPR000904 (FlyBase Curators et al., 2004-) guanyl-nucleotide exchange factor activity inferred from sequence or structural similarity with UniProtKB:Q9LZX8 (FlyBase Genome Annotators, 2002-2003) non-traceable author statement (Chen, 2003.8.27)
Biological Process
CV term Evidence References
myoblast fusion non-traceable author statement (Chen, 2003.8.27) regulation of ARF protein signal transduction inferred from electronic annotation with InterPro:IPR000904 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR000904 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions siz allele Gene References sizP1.Scer\UAS sli (Onel et al., 2004) sizP2.Scer\UAS sli (Onel et al., 2004) sizU112 fra (Hummel et al., 1999) sli (Onel et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65580 DroID - A comprehensive database of gene and protein interactions. • FBgn0026179 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40327
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24294 Dgri\GH14566 Dmoj\GI13893 Dwil\GK25417
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000906-PA Aedes aegypti (mosquito) AGAP011421-PA Anopheles gambiae (mosquito) XP_396854.3 Apis mellifera (honey bee) XP_001945143.1 Acyrthosiphon pisum (pea aphid) XP_001902353.1 Brugia malayi (roundworm nematode) BGIBMGA004600-PA Bombyx mori (silk worm) ENSBTAP00000004201 Bos taurus (bovine) CN04435 Caenorhabditis brenneri (small nematode) CBP28711 Caenorhabditis briggsae (nematode) CE39515 Caenorhabditis elegans (worm) ENSCAFP00000006470 Canis familiaris (dog) JA09776 Caenorhabditis japonica (nematode) CPIJ002812 Culex pipens (mosquito) ENSCPOP00000015695 Cavia porcellus (guinea pig) RP33088 Caenorhabditis remanei (nematode) ENSDARP00000043090 Danio rerio (zebra fish) ENSECAP00000021203 Equus caballus (horse) ENSGACP00000014737 Gymnopilus aculeatus (mushroom) ENSGALP00000008067 Gallus gallus (chicken) ENSP00000273221 Homo sapiens (human) ISCW004849-PA Ixodes scapularis (deer tick) 8424 Monocosta brevicollis (choanoflagellate) ENSMODP00000010587 Monodelphis domestica (gray opossum) ENSMMUP00000001791 Macaca mulatta (rhesus monkey) ENSMUSP00000042960 Mus musculus (house mouse) XP_001603344.1 Nasonia vitripennis (wasp) ENSOANP00000009012 Ornithorynchus anatinus (platypus) ENSORLP00000016148 Oryzias latipes (japanese killifish) PHUM006218-PA Pediculus humanus (human body louse) ENSPPYP00000014980 Pongo pygmaeus (orangutan) ENSPTRP00000025258 Pan troglodytes (chimpanzee) ENSRNOP00000004620 Rattus norvegicus (norway rat) Smp_016380 Schistosoma mansoni (trematode parasite) XP_784781.2 Strongylocentrotus purpuratus (purple sea urchin) 52469 Trichoplax adhaerens (metazoa) XP_972609.1 Tribolium castaneum (red flour beetle) ENSTNIP00000010197 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000005565 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000015592 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12173 LH13058 ISCW004849 FBgn0237060 FBgn0237059 FBgn0227376 FBgn0199002 FBgn0186604 FBgn0177210 JGI_V11_31197 FBgn0245205 FBgn0164446 FBgn0160014 FBgn0156042 FBgn0147674 FBgn0136647 FBgn0122042 FBgn0108393 FBgn0101288 CPIJ002812 BGIBMGA004600 ACYPI003771 GB14817 AGAP011421 AAEL000906 PB24117 PHUM029790 GLEAN_05167
Stocks & Reagents
Stocks Listed in FlyBase ( 21 )
Harvard	- P{XP}sizd04881 - P{XP}sizd08140 - P{XP}sizd11324 - PBac{PB}sizc01067 - PBac{PB}sizc01699 - PBac{PB}sizc06339 - PBac{RB}size01391 - PBac{RB}size02726 - PBac{RB}size03674 - PBac{WH}sizf04631 - PBac{WH}sizf04908
VDRC	v106168 P{KK103616}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR03J02 BACR24H03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 64 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10594 GM06994 LP01489 RE02556
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT11181 GH14890 GM08468 LD44876 RE05422 RE44556
Other clones	5818 17219 29105 39183 39976 41469 43795 44932 52644 55048 57662 70140 70619 107881 160290 173957 175301 214407.7 214439.64 214447.51 214531.43 283145 542910 CK01.3D.D11 CK01.58B.F1 CK01.66B.H4 CK01.68B.A4 CK01.121A.B6 CK01.121B.C8 EC23665 EC29965 EK007816 EK046921 EK053862 EK054734 EK092639 EK092744 EK129321 EK137050 EK160322 EK160426 EK168122 EK178626 EK197317 EK198543 EK236033 EK239706 EK263320 EK297305 EK308742 EN11563 EP01634 EP02327 EP19007
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026179 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40327
Antibody Information
Other Information
Discoverer
Etymology
	"schizo" means "split" in German. (Hummel et al., 1999)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: loner CG32434 (FlyBase, 1996-)
Source for database merge of	Source for merge of: CG10577 CG12980 CG12981 (FlyBase Genome Annotators, 2002-2003) Source for merge of: siz loner (Onel et al., 2004)
Additional comments	Annotations CG10577, CG12980 and CG12981 merged as CG32434 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for identity of loner CG32434 was sequence comparison (date:031005). (FlyBase, 1996-)
Other Comments
	Two EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo. (Hummel et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_168881 NM_206407 NM_001043153 NM_001170016 RefSeq (Proteins) • NP_730594 NP_996129 NP_001036618 NP_001163487 DDBJ / EMBL / GenBank • AAF51675 AAL13562 AAQ75367 AAQ75368 AAS65082 AAV36918 AAV36965 ABI31265 ACZ94758 AI133851 AI258331 AW941752 AY058333 AY375488 AY375489 BI163213 BT016033 BT016080 CL632196 CZ467374 CZ470612 CZ474187 CZ476175 CZ477676 CZ479199 CZ480497 CZ481181 CZ481427 CZ487171 CZ487494 DU708602 Entrez Gene - A searchable database of RefSeq genes. • 40327 UniProtKB/TrEMBL • E1JI59 Q5U112 Q5U159 Q6U9V3 Q7KTX2 Q9VP80 Q95U36
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • IQ motif, EF-hand binding site (IPR000048) SEC7-like (IPR000904) Pleckstrin homology-type (IPR011993) Pleckstrin homology domain (IPR001849) SEC7-like, alpha orthogonal bundle (IPR023394)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65580 DroID - A comprehensive database of gene and protein interactions. • FBgn0026179 DRSC - Results from RNAi screens. • FBgn0026179 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026179 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32434-RB;CT32172 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026179 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40327 InParanoid A subset of ortholog calls from InParanoid. • AAEL000906-PA Aedes aegypti (mosquito) AGAP011421-PA Anopheles gambiae (mosquito) XP_396854.3 Apis mellifera (honey bee) XP_001945143.1 Acyrthosiphon pisum (pea aphid) XP_001902353.1 Brugia malayi (roundworm nematode) BGIBMGA004600-PA Bombyx mori (silk worm) ENSBTAP00000004201 Bos taurus (bovine) CN04435 Caenorhabditis brenneri (small nematode) CBP28711 Caenorhabditis briggsae (nematode) CE39515 Caenorhabditis elegans (worm) ENSCAFP00000006470 Canis familiaris (dog) JA09776 Caenorhabditis japonica (nematode) CPIJ002812 Culex pipens (mosquito) ENSCPOP00000015695 Cavia porcellus (guinea pig) RP33088 Caenorhabditis remanei (nematode) ENSDARP00000043090 Danio rerio (zebra fish) ENSECAP00000021203 Equus caballus (horse) ENSGACP00000014737 Gymnopilus aculeatus (mushroom) ENSGALP00000008067 Gallus gallus (chicken) ENSP00000273221 Homo sapiens (human) ISCW004849-PA Ixodes scapularis (deer tick) 8424 Monocosta brevicollis (choanoflagellate) ENSMODP00000010587 Monodelphis domestica (gray opossum) ENSMMUP00000001791 Macaca mulatta (rhesus monkey) ENSMUSP00000042960 Mus musculus (house mouse) XP_001603344.1 Nasonia vitripennis (wasp) ENSOANP00000009012 Ornithorynchus anatinus (platypus) ENSORLP00000016148 Oryzias latipes (japanese killifish) PHUM006218-PA Pediculus humanus (human body louse) ENSPPYP00000014980 Pongo pygmaeus (orangutan) ENSPTRP00000025258 Pan troglodytes (chimpanzee) ENSRNOP00000004620 Rattus norvegicus (norway rat) Smp_016380 Schistosoma mansoni (trematode parasite) XP_784781.2 Strongylocentrotus purpuratus (purple sea urchin) 52469 Trichoplax adhaerens (metazoa) XP_972609.1 Tribolium castaneum (red flour beetle) ENSTNIP00000010197 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000005565 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000015592 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40327 modMine - Data generated by the modENCODE project. • FBgn0026179 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12173 LH13058 ISCW004849 FBgn0237060 FBgn0237059 FBgn0227376 FBgn0199002 FBgn0186604 FBgn0177210 JGI_V11_31197 FBgn0245205 FBgn0164446 FBgn0160014 FBgn0156042 FBgn0147674 FBgn0136647 FBgn0122042 FBgn0108393 FBgn0101288 CPIJ002812 BGIBMGA004600 ACYPI003771 GB14817 AGAP011421 AAEL000906 PB24117 PHUM029790 GLEAN_05167 REDfly - A database of transcriptional regulatory elements. • FBgn0026179
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG10577 (Brody et al., 2002, ) CG12980   CG12981   CG32434 (Cox et al., 2004, Milchanowski et al., 2004, Onel et al., 2004, Matyash et al., 2004, Giot et al., 2003, Lawniczak and Begun, 2004, Keleman et al., 2009.8.5, Gupta et al., 2009, Morozova et al., 2006, Aerts et al., 2010) loner (Donaldson, 2003, Chen and Olson, 2004, Chen et al., 2003, Richardson and Baylies, 2005, Taylor, 2003, FlyBase, 1996-, Reeves and Posakony, 2005, . Rochlin et al., 2007, Richardson et al., 2007) Loner (Chen et al., 2007) siz (Buszczak et al., 2007, Aerts et al., 2010)
Name Synonym	loner (Beckett and Baylies, 2007, Bulchand et al., 2010) Loner (Bulchand et al., 2010) schizo (Hummel et al., 1999, Raghu et al., 2009, Gupta et al., 2009, Edwards et al., 2009, Edwards et al., 2009)
Secondary FlyBase IDs
	FBgn0037047 FBgn0037048 FBgn0037049 FBgn0052434
References ( 53 )
Generate a list of	All references relating to this gene ( 53 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 3 ) Review  ( 6 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 4 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 4 )
	Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Zwarts et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(41): 17070--17075 Complex genetic architecture of Drosophila aggressive behavior. [FBrf0216413] Aerts et al., 2010, PLoS Biol. 8(7): e1000435 Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in Drosophila Uncovers a Regulatory Basis for Sensory Specification. [FBrf0211419] Bulchand et al., 2010, PLoS ONE 5(2): e9374 The intracellular domain of dumbfounded affects myoblast fusion efficiency and interacts with rolling pebbles and loner. [FBrf0210103] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...