A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\siz

General Information
SymbolDmel\sizSpeciesD. melanogaster
NameschizoAnnotation symbolCG32434
Feature typeprotein_coding_geneFlyBase IDFBgn0026179
Gene Model StatusCurrent Stock availability 21 publicly available
Also Known Asloner
Genomic Location
Chromosome (arm)3LRecombination map3-51 +/- 3
Cytogenetic map78A5-78B1Sequence location3L:21,027,639..21,068,544 [+]

Genomic Maps

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modENCODE GBrowse
detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene schizo is referred to in FlyBase by the symbol Dmel\siz (CG32434, FBgn0026179). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process: myoblast fusion; central nervous system development; inter-male aggressive behavior; actin cytoskeleton organization. 52 alleles are reported. The phenotypes of these alleles are annotated with: commissure; ventral nerve cord commissure; midline glial cell; embryonic myoblast. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: IQ motif, EF-hand binding site; Pleckstrin homology domain; Pleckstrin homology-type; SEC7-like; SEC7-like, alpha orthogonal bundle. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Gene sequence location is 3L:21027639..21068544.

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Description
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This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
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FB2011_10
References
FB2012_01
References
Sequence features
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
78A5-78B1  
Limits computationally determined from genome sequence between P{EP}fngEP3082&P{lacW}skdL7062 and P{lacW}l(3)L5541L5541  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\siz for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0078288 FBtr0304820 FBtr0078326 FBtr0078289 FBtr0301602 FBtr0078290 FBtr0304821 FBtr0111038 FBtr0078324 FBpp0077946 FBpp0293360 FBpp0077982 FBpp0077947 FBpp0290817 FBpp0077948 FBpp0293361 FBpp0110337 FBpp0077980 FBti0048128 FBti0028793 FBti0040196 FBti0112051 FBti0104741 FBti0034507 FBti0113376 FBti0109005 FBti0102206 FBti0009944 FBti0104701 FBti0056561 FBti0036241 FBti0111537 FBti0106359 FBti0039973 FBti0100196 FBti0113396 FBti0109404 FBti0066958 FBti0043765 FBti0125836_2 FBti0125836_1 FBti0047060 FBti0045761 FBti0043429 FBti0105994 FBti0024214 FBti0052060 FBti0111361 FBti0072113 FBti0047866 FBti0057263 FBti0069928 FBti0055670 FBti0105137 FBti0051889 FBti0070930 FBti0064330 FBti0048425 FBti0143513 FBti0141076 FBti0064329
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0078290
  5314
  1313
FBtr0078289
  5126
  1325
FBtr0111038
  4654
  1210
FBtr0301602
  4931
  1220
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
siz-PA  
FBpp0077948  
142.9  
1313  
9.70  
siz-PB  
FBpp0077947  
144.0  
1325  
8.92  
siz-PC  
FBpp0110337  
131.4  
1210  
9.39  
siz-PD  
FBpp0290817  
132.7  
1220  
9.40  
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view Sin-RA Sin-RC CG10581-RA siz-RB siz-RD siz-RA CG43072-RA siz-RC ko-RA
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0026179


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0026179
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No expression (0 - 0)
 
Extremely low expression (1 - 10)
 
Very low expression (11 - 100)
 
Low expression (101 - 400)
 
Moderate expression (401 - 1400)
 
Moderately high expression (1401 - 4000)
 
High expression (4001 - 10000)
 
Very high expression (10001 - 100000)
 
Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0026179 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 1888
embryo 02-04hr
 
 3006
embryo 04-06hr
 
 4485
embryo 06-08hr
 
 4128
embryo 08-10hr
 
 2457
embryo 10-12hr
 
 1859
embryo 12-14hr
 
 1878
embryo 14-16hr
 
 2806
embryo 16-18hr
 
 2619
embryo 18-20hr
 
 2467
embryo 20-22hr
 
 1621
embryo 22-24hr
 
 1574
larva L1
 
 943
larva L2
 
 994
larva L3 12hr old
 
 770
larva L3 puffstage 1-2
 
 751
larva L3 puffstage 3-6
 
 1654
larva L3 puffstage 7-9
 
 2026
white prepupae new
 
 1766
white prepupae 12hr
 
 1395
white prepupae 24hr
 
 1232
pupae 2d postWPP
 
 1541
pupae 3d postWPP
 
 1193
pupae 4d postWPP
 
 1631
adult male 01day
 
 1423
adult male 05day
 
 1723
adult male 30day
 
 1771
adult female 01day
 
 1291
adult female 05day
 
 1274
adult female 30day
 
 1379
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (1888)
embryo 02-04hr
 (3006)
embryo 04-06hr
 (4485)
embryo 06-08hr
 (4128)
embryo 08-10hr
 (2457)
embryo 10-12hr
 (1859)
embryo 12-14hr
 (1878)
embryo 14-16hr
 (2806)
embryo 16-18hr
 (2619)
embryo 18-20hr
 (2467)
embryo 20-22hr
 (1621)
embryo 22-24hr
 (1574)
larva L1
 (943)
larva L2
 (994)
larva L3 12hr old
 (770)
larva L3 puffstage 1-2
 (751)
larva L3 puffstage 3-6
 (1654)
larva L3 puffstage 7-9
 (2026)
white prepupae new
 (1766)
white prepupae 12hr
 (1395)
white prepupae 24hr
 (1232)
pupae 2d postWPP
 (1541)
pupae 3d postWPP
 (1193)
pupae 4d postWPP
 (1631)
adult male 01day
 (1423)
adult male 05day
 (1723)
adult male 30day
 (1771)
adult female 01day
 (1291)
adult female 05day
 (1274)
adult female 30day
 (1379)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (1888)
embryo 02-04hr
 (3006)
embryo 04-06hr
 (4485)
embryo 06-08hr
 (4128)
embryo 08-10hr
 (2457)
embryo 10-12hr
 (1859)
embryo 12-14hr
 (1878)
embryo 14-16hr
 (2806)
embryo 16-18hr
 (2619)
embryo 18-20hr
 (2467)
embryo 20-22hr
 (1621)
embryo 22-24hr
 (1574)
larva L1
 
 943
larva L2
 
 994
larva L3 12hr old
 
 770
larva L3 puffstage 1-2
 
 751
larva L3 puffstage 3-6
 (1654)
larva L3 puffstage 7-9
 (2026)
white prepupae new
 (1766)
white prepupae 12hr
 
 1395
white prepupae 24hr
 
 1232
pupae 2d postWPP
 (1541)
pupae 3d postWPP
 
 1193
pupae 4d postWPP
 (1631)
adult male 01day
 1423
adult male 05day
 (1723)
adult male 30day
 (1771)
adult female 01day
 
 1291
adult female 05day
 
 1274
adult female 30day
 
 1379
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1888
embryo 02-04hr
 
 3006
embryo 04-06hr
 
 4485
embryo 06-08hr
 
 4128
embryo 08-10hr
 
 2457
embryo 10-12hr
 
 1859
embryo 12-14hr
 
 1878
embryo 14-16hr
 
 2806
embryo 16-18hr
 
 2619
embryo 18-20hr
 
 2467
embryo 20-22hr
 
 1621
embryo 22-24hr
 
 1574
larva L1
 
 943
larva L2
 
 994
larva L3 12hr old
 
 770
larva L3 puffstage 1-2
 
 751
larva L3 puffstage 3-6
 
 1654
larva L3 puffstage 7-9
 
 2026
white prepupae new
 
 1766
white prepupae 12hr
 
 1395
white prepupae 24hr
 
 1232
pupae 2d postWPP
 
 1541
pupae 3d postWPP
 
 1193
pupae 4d postWPP
 
 1631
adult male 01day
 
 1423
adult male 05day
 
 1723
adult male 30day
 
 1771
adult female 01day
 
 1291
adult female 05day
 
 1274
adult female 30day
 
 1379
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1888
embryo 02-04hr
 
 3006
embryo 04-06hr
 
 4485
embryo 06-08hr
 
 4128
embryo 08-10hr
 
 2457
embryo 10-12hr
 
 1859
embryo 12-14hr
 
 1878
embryo 14-16hr
 
 2806
embryo 16-18hr
 
 2619
embryo 18-20hr
 
 2467
embryo 20-22hr
 
 1621
embryo 22-24hr
 
 1574
larva L1
 
 943
larva L2
 
 994
larva L3 12hr old
 
 770
larva L3 puffstage 1-2
 
 751
larva L3 puffstage 3-6
 
 1654
larva L3 puffstage 7-9
 
 2026
white prepupae new
 
 1766
white prepupae 12hr
 
 1395
white prepupae 24hr
 
 1232
pupae 2d postWPP
 
 1541
pupae 3d postWPP
 
 1193
pupae 4d postWPP
 
 1631
adult male 01day
 
 1423
adult male 05day
 
 1723
adult male 30day
 
 1771
adult female 01day
 
 1291
adult female 05day
 
 1274
adult female 30day
 
 1379
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0026179 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 1888
embryo 02-04hr
 
 3006
embryo 04-06hr
 
 4485
embryo 06-08hr
 
 4128
embryo 08-10hr
 
 2457
embryo 10-12hr
 
 1859
embryo 12-14hr
 
 1878
embryo 14-16hr
 
 2806
embryo 16-18hr
 
 2619
embryo 18-20hr
 
 2467
embryo 20-22hr
 
 1621
embryo 22-24hr
 
 1574
larva L1
 
 943
larva L2
 
 994
larva L3 12hr old
 
 770
larva L3 puffstage 1-2
 
 751
larva L3 puffstage 3-6
 
 1654
larva L3 puffstage 7-9
 
 2026
white prepupae new
 
 1766
white prepupae 12hr
 
 1395
white prepupae 24hr
 
 1232
pupae 2d postWPP
 
 1541
pupae 3d postWPP
 
 1193
pupae 4d postWPP
 
 1631
adult male 01day
 
 1423
adult male 05day
 
 1723
adult male 30day
 
 1771
adult female 01day
 
 1291
adult female 05day
 
 1274
adult female 30day
 
 1379
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (1888)
embryo 02-04hr
 (3006)
embryo 04-06hr
 (4485)
embryo 06-08hr
 (4128)
embryo 08-10hr
 (2457)
embryo 10-12hr
 (1859)
embryo 12-14hr
 (1878)
embryo 14-16hr
 (2806)
embryo 16-18hr
 (2619)
embryo 18-20hr
 (2467)
embryo 20-22hr
 (1621)
embryo 22-24hr
 (1574)
larva L1
 (943)
larva L2
 (994)
larva L3 12hr old
 (770)
larva L3 puffstage 1-2
 (751)
larva L3 puffstage 3-6
 (1654)
larva L3 puffstage 7-9
 (2026)
white prepupae new
 (1766)
white prepupae 12hr
 (1395)
white prepupae 24hr
 (1232)
pupae 2d postWPP
 (1541)
pupae 3d postWPP
 (1193)
pupae 4d postWPP
 (1631)
adult male 01day
 (1423)
adult male 05day
 (1723)
adult male 30day
 (1771)
adult female 01day
 (1291)
adult female 05day
 (1274)
adult female 30day
 (1379)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 1888
embryo 02-04hr
 (3006)
embryo 04-06hr
 (4485)
embryo 06-08hr
 (4128)
embryo 08-10hr
 2457
embryo 10-12hr
 1859
embryo 12-14hr
 1878
embryo 14-16hr
 (2806)
embryo 16-18hr
 (2619)
embryo 18-20hr
 2467
embryo 20-22hr
 1621
embryo 22-24hr
 1574
larva L1
 
 943
larva L2
 
 994
larva L3 12hr old
 
 770
larva L3 puffstage 1-2
 
 751
larva L3 puffstage 3-6
 1654
larva L3 puffstage 7-9
 2026
white prepupae new
 1766
white prepupae 12hr
 
 1395
white prepupae 24hr
 
 1232
pupae 2d postWPP
 1541
pupae 3d postWPP
 
 1193
pupae 4d postWPP
 1631
adult male 01day
 1423
adult male 05day
 1723
adult male 30day
 1771
adult female 01day
 
 1291
adult female 05day
 
 1274
adult female 30day
 
 1379
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1888
embryo 02-04hr
 
 3006
embryo 04-06hr
 
 4485
embryo 06-08hr
 
 4128
embryo 08-10hr
 
 2457
embryo 10-12hr
 
 1859
embryo 12-14hr
 
 1878
embryo 14-16hr
 
 2806
embryo 16-18hr
 
 2619
embryo 18-20hr
 
 2467
embryo 20-22hr
 
 1621
embryo 22-24hr
 
 1574
larva L1
 
 943
larva L2
 
 994
larva L3 12hr old
 
 770
larva L3 puffstage 1-2
 
 751
larva L3 puffstage 3-6
 
 1654
larva L3 puffstage 7-9
 
 2026
white prepupae new
 
 1766
white prepupae 12hr
 
 1395
white prepupae 24hr
 
 1232
pupae 2d postWPP
 
 1541
pupae 3d postWPP
 
 1193
pupae 4d postWPP
 
 1631
adult male 01day
 
 1423
adult male 05day
 
 1723
adult male 30day
 
 1771
adult female 01day
 
 1291
adult female 05day
 
 1274
adult female 30day
 
 1379
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1888
embryo 02-04hr
 
 3006
embryo 04-06hr
 
 4485
embryo 06-08hr
 
 4128
embryo 08-10hr
 
 2457
embryo 10-12hr
 
 1859
embryo 12-14hr
 
 1878
embryo 14-16hr
 
 2806
embryo 16-18hr
 
 2619
embryo 18-20hr
 
 2467
embryo 20-22hr
 
 1621
embryo 22-24hr
 
 1574
larva L1
 
 943
larva L2
 
 994
larva L3 12hr old
 
 770
larva L3 puffstage 1-2
 
 751
larva L3 puffstage 3-6
 
 1654
larva L3 puffstage 7-9
 
 2026
white prepupae new
 
 1766
white prepupae 12hr
 
 1395
white prepupae 24hr
 
 1232
pupae 2d postWPP
 
 1541
pupae 3d postWPP
 
 1193
pupae 4d postWPP
 
 1631
adult male 01day
 
 1423
adult male 05day
 
 1723
adult male 30day
 
 1771
adult female 01day
 
 1291
adult female 05day
 
 1274
adult female 30day
 
 1379
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0026179


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0026179
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (1000 - 25000)

Heatmap
Tissue   Expression Level
Larval Central Nervous System no informative data
Larval Midgut no informative data
Larval Hindgut no informative data
Larval Malpighian Tubules no informative data
Larval Fat Body no informative data
Larval Salivary Gland no informative data
Larval Trachea no informative data
Larval Carcass no informative data
Adult Head no informative data
Adult Eye no informative data
Adult Brain no informative data
Adult Thoracic-Abdominal Ganglion no informative data
Adult Crop no informative data
Adult Midgut no informative data
Adult Hindgut no informative data
Adult Malpighian Tubules no informative data
Adult Fat Body no informative data
Adult Salivary Gland no informative data
Adult Heart no informative data
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca no informative data
Adult Ovary no informative data
Adult Testis no informative data
Adult Male Accessory Gland no informative data
Adult Carcass no informative data

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyExpress - Embryonic expression images (BDGP data)
hide Alleles & Phenotypes
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Lethality
Allele
Sterility
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Other Phenotypes
Allele
Phenotype manifest in
Allele
hide Classical Alleles ( 31 )
For All Classical Alleles Show

Allele of sizClassMutagenStocksKnown lesion
sizKG08286
2 --
sizc01067
1 --
sizc016991 --
sizc063391 --
sizd048811 --
sizd08140
1 --
sizd113241 --
sizDG126011 --
size013911 --
size027261 --
size036741 --
sizEY096771 --
sizf046311 --
sizf049081 --
sizLA000331 --
sizMI01727
1 --
sizNP4792
1 --
sizT1032amorphic allele - genetic evidence0 Yes
sizT2057amorphic allele - genetic evidence0 Yes
siz3hypomorphic allele - genetic evidence
0 --
sizBG00735
0 --
sizC1-28hypomorphic allele - genetic evidence0 --
sizCB032880 Yes
sizCPTI0045360 Yes
sizd083180 --
size034050 --
sizl(3)30 Yes
sizP2240 Yes
sizT1015
0 --
sizU112loss of function allele0 --
sizunspecified
0 --
hide Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show

Allele of sizClassMutagenStocksKnown lesion
sizGD148952 Yes
sizKK1036161 Yes
siziso1.Act5C0 Yes
siziso1.E->K.Scer\UAS0 Yes
siziso1.E->K.Tub0 Yes
siziso1.Scer\UAS0 Yes
siziso1.Tub0 Yes
siziso1.ΔIQ.Scer\UAS0 Yes
siziso1.ΔIQ.Tub0 Yes
siziso1.ΔPH.Scer\UAS0 Yes
siziso1.ΔPH.Tub0 Yes
siziso1.ΔSec7.Scer\UAS0 Yes
siziso1.ΔSec7.Tub0 Yes
siziso2.Act5C0 Yes
siziso2.Scer\UAS0 Yes
siziso2.Tub0 Yes
siziso3.Act5C0 Yes
siziso3.Scer\UAS0 Yes
siziso3.Tub0 Yes
sizP1.Scer\UAS0 Yes
sizP2.Scer\UAS0 Yes
hide Aneuploid Aberrations
Disrupted in
Not disrupted in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
insertion of enhancer trap binary system
hide Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
hide Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term
References
Cellular Component ( 0 terms)
hide Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term
References
inferred from sequence or structural similarity with UniProtKB:Q9LZX8
non-traceable author statement
Biological Process
CV term
References
non-traceable author statement
Cellular Component
CV term
References
inferred from electronic annotation with InterPro:IPR000904
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hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
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hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
siz allele
Gene
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BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
InParanoid A subset of ortholog calls from InParanoid.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
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hide Stocks Listed in FlyBase ( 21 )
Harvard
VDRC
hide Genomic Clones ( 2 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 64 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
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hide Etymology
"schizo" means "split" in German.
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for identity of: loner CG32434
Source for database merge of
Source for merge of: CG10577 CG12980 CG12981
Source for merge of: siz loner
Additional comments
Annotations CG10577, CG12980 and CG12981 merged as CG32434 in release 3 of the genome annotation.
Source for identity of loner CG32434 was sequence comparison (date:031005).
hide Other Comments
Two EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo.
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Linkouts
BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InParanoid A subset of ortholog calls from InParanoid.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
REDfly - A database of transcriptional regulatory elements.
hide Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym
CG12980
 
CG12981
 
Name Synonym
Secondary FlyBase IDs
  • FBgn0037047
  • FBgn0037048
  • FBgn0037049
  • FBgn0052434
hide References ( 53 )
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hide Recent research papers ( 4 )
Carreira et al., 2011, BMC Dev. Biol. 11: 32
Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273]
Zwarts et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(41): 17070--17075
Complex genetic architecture of Drosophila aggressive behavior. [FBrf0216413]
Aerts et al., 2010, PLoS Biol. 8(7): e1000435
Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in Drosophila Uncovers a Regulatory Basis for Sensory Specification. [FBrf0211419]
Bulchand et al., 2010, PLoS ONE 5(2): e9374
The intracellular domain of dumbfounded affects myoblast fusion efficiency and interacts with rolling pebbles and loner. [FBrf0210103]
hide Recent reviews (0)
All reviews listed in FlyBase were published before 2010