FlyBase Gene Report: Dmel\Rok

General Information

Symbol

Dmel\Rok

Species

D. melanogaster

Name

Rho kinase

Annotation Symbol

CG9774

Feature Type

protein_coding_gene

FlyBase ID

FBgn0026181

Gene Model Status

Current

Stock Availability

25 publicly available

Gene Summary

Rho kinase (Rok) encodes a kinase that, when activated by the GTP form of the product of Rho1, phosphorylates and modulates cytoskeletal proteins, particularly myosin II. Dynamic regulation of this kinase in subcellular locales influences cell polarization, movement, and shape during interphase and mitosis. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Drok, ROCK, Rho-associated kinase, DRho-kinase, ROCK1

Key Links

Genomic Location

Cytogenetic map

14F2-14F4

Sequence location

X:16,624,012..16,637,414 [-]

Recombination map

1-54

RefSeq locus

NC_004354 REGION:16624012..16637414

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (50 terms)

Molecular Function (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables GTPase binding

inferred from physical interaction with FLYBASE:Rho1; FB:FBgn0014020

(Winter et al., 2001)

enables protein binding

inferred from physical interaction with UniProtKB:A1Z9P3

(Mohan et al., 2012, Bolinger et al., 2010)

inferred from physical interaction with FLYBASE:Rho1; FB:FBgn0014020

(Mizuno et al., 1999)

enables protein serine/threonine kinase activity

inferred from direct assay

(Winter et al., 2001, Mizuno et al., 1999)

inferred from mutant phenotype

(Tian et al., 2023)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR017441

(InterPro Project Members, 2004-)

enables protein serine/threonine kinase activity

inferred from electronic annotation with InterPro:IPR000961, InterPro:IPR020684

(InterPro Project Members, 2004-)

enables Rho-dependent protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000542090

(GO Reference Genome Project, 2011-)

enables small GTPase binding

inferred from electronic annotation with InterPro:IPR015008

(InterPro Project Members, 2004-)

Biological Process (36 terms)

Terms Based on Experimental Evidence (31 terms)

CV Term

Evidence

References

involved_in actin cytoskeleton organization

inferred from mutant phenotype

(Abreu-Blanco et al., 2014, Rauskolb et al., 2014, Verdier et al., 2006)

involved_in apical constriction involved in gastrulation

inferred from mutant phenotype

(Vasquez et al., 2014)

involved_in assembly of apicomedial cortex actomyosin

inferred from mutant phenotype

(Chung et al., 2017)

inferred from direct assay

(Mason et al., 2013)

involved_in epidermis development

inferred from mutant phenotype

(Ninov et al., 2007)

involved_in establishment of imaginal disc-derived wing hair orientation

inferred from mutant phenotype

(Winter et al., 2001)

involved_in establishment of ommatidial planar polarity

inferred from mutant phenotype

(Winter et al., 2001)

involved_in establishment of planar polarity

inferred from mutant phenotype

(Simões et al., 2010)

involved_in establishment of protein localization

inferred from mutant phenotype

(Dean et al., 2005)

involved_in female germline ring canal stabilization

inferred from mutant phenotype

(Verdier et al., 2006)

involved_in imaginal disc-derived wing hair organization

inferred from mutant phenotype

(Winter et al., 2001)

inferred from genetic interaction with FLYBASE:dsh; FB:FBgn0000499

(Winter et al., 2001)

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085

(Winter et al., 2001)

involved_in maintenance of epithelial cell apical/basal polarity

inferred from mutant phenotype

(Tian et al., 2023)

involved_in maintenance of protein location in cell cortex

inferred from mutant phenotype

(Royou et al., 2002)

involved_in mitotic cell cycle

inferred from mutant phenotype

(Hickson et al., 2006)

involved_in mitotic cytokinesis, division site positioning

inferred from mutant phenotype

(Tsankova et al., 2017)

involved_in mitotic cytokinesis

inferred from mutant phenotype

(Hickson et al., 2006, Dean et al., 2005)

inferred from direct assay

(Dean and Spudich, 2006)

involved_in mitotic spindle elongation

inferred from mutant phenotype

(Hickson et al., 2006)

involved_in morphogenesis of embryonic epithelium

inferred from mutant phenotype

(Dawes-Hoang et al., 2005)

involved_in nuclear axial expansion

inferred from mutant phenotype

(Royou et al., 2002)

involved_in nurse cell nucleus anchoring

inferred from mutant phenotype

(Verdier et al., 2006)

involved_in oocyte axis specification

inferred from mutant phenotype

(Verdier et al., 2006)

involved_in oocyte development

inferred from mutant phenotype

(Verdier et al., 2006)

involved_in ovarian nurse cell to oocyte transport

inferred from mutant phenotype

(Verdier et al., 2006)

involved_in positive regulation of stress fiber assembly

inferred from genetic interaction with FLYBASE:Fhos; FB:FBgn0266084

(Lammel et al., 2014)

involved_in positive regulation of wound healing

inferred from mutant phenotype

(Abreu-Blanco et al., 2014)

involved_in regulation of actin cytoskeleton organization

inferred from mutant phenotype

(Kunda et al., 2008)

involved_in regulation of actin filament bundle assembly

inferred from mutant phenotype

(Winter et al., 2001)

inferred from genetic interaction with FLYBASE:dsh; FB:FBgn0000499

(Winter et al., 2001)

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085

(Winter et al., 2001)

involved_in regulation of axonogenesis

inferred from genetic interaction with FLYBASE:LIMK1; FB:FBgn0283712

(Ng and Luo, 2004)

involved_in regulation of cell junction assembly

inferred from genetic interaction with FLYBASE:Pten; FB:FBgn0026379

(Bardet et al., 2013)

involved_in regulation of cell shape

inferred from mutant phenotype

(Dawes-Hoang et al., 2005)

involved_in regulation of myoblast fusion

inferred from genetic interaction with FLYBASE:Rho1; FB:FBgn0014020

(Kim et al., 2015)

involved_in Rho protein signal transduction

inferred from physical interaction with FLYBASE:Rho1; FB:FBgn0014020

(Mizuno et al., 1999)

Terms Based on Predictions or Assertions (11 terms)

CV Term

Evidence

References

involved_in actin cytoskeleton organization

inferred from electronic annotation with InterPro:IPR020684

(InterPro Project Members, 2004-)

involved_in actomyosin structure organization

inferred from biological aspect of ancestor with PANTHER:PTN002743840

(GO Reference Genome Project, 2011-)

involved_in apical constriction

traceable author statement

(Vishwakarma et al., 2022)

involved_in cortical actin cytoskeleton organization

inferred from biological aspect of ancestor with PANTHER:PTN000542090

(GO Reference Genome Project, 2011-)

involved_in dorsal closure

traceable author statement

(Harden, 2002)

involved_in embryonic morphogenesis

inferred from biological aspect of ancestor with PANTHER:PTN000542090

(GO Reference Genome Project, 2011-)

involved_in establishment of planar polarity

traceable author statement

(Tree et al., 2002)

involved_in mitotic cytokinesis

inferred from biological aspect of ancestor with PANTHER:PTN000542090

(GO Reference Genome Project, 2011-)

involved_in regulation of actin cytoskeleton organization

inferred from biological aspect of ancestor with PANTHER:PTN000542090

(GO Reference Genome Project, 2011-)

involved_in regulation of cell junction assembly

inferred from biological aspect of ancestor with PANTHER:PTN000542090

(GO Reference Genome Project, 2011-)

involved_in Rho protein signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000542090

(GO Reference Genome Project, 2011-)

Cellular Component (8 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

colocalizes_with apical cortex

inferred from direct assay

(Vasquez et al., 2014)

located_in apicomedial cortex

inferred from direct assay

(Chung et al., 2017, Mason et al., 2013)

located_in cell cortex

inferred from direct assay

(Tsankova et al., 2017)

located_in cell-cell contact zone

inferred from direct assay

(Kim et al., 2015)

located_in cell-cell junction

inferred from direct assay

(Beati et al., 2018)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN002743840

(GO Reference Genome Project, 2011-)

is_active_in cytoskeleton

inferred from biological aspect of ancestor with PANTHER:PTN002743840

(GO Reference Genome Project, 2011-)

is_active_in cytosol

traceable author statement

(Vishwakarma et al., 2022)

Gene Group (FlyBase)

UNCLASSIFIED AGC KINASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

UNCLASSIFIED AGC KINASES -: This group comprises AGC kinases that do not classify under other groups in FlyBase.

Summary (Interactive Fly)

Rho-kinase - plays a role in planar cell polarity - required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis - directs Bazooka/Par-3 planar polarity during Drosophila axis elongation

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Rok for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VXE3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Rok-RA

FBtr0074286

NM_080535

7190

1390

Rok-RB

FBtr0340151

NM_001298406

7163

1381

Rok-RC

FBtr0340152

NM_001298407

5220

1374

Rok-RD

FBtr0340153

NM_001298408

5293

1381

Additional Transcript Data and Comments

Reported size (kB)

6.259 (longest cDNA)

(Mizuno et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Rok-PA

FBpp0074061

160.3

1390

6.47

FBpp0309137

159.3

1381

6.45

FBpp0309138

158.6

1374

6.44

FBpp0309139

159.1

1381

6.33

X2JKQ8

NP_001285337

AHN59807

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

1390 (aa); 160 (kD predicted)

(Mizuno et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rok using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Rok_1
Rok_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.85

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | ubiquitous

(Mizuno et al., 1999)

third instar larval stage

imaginal disc | ubiquitous

(Mizuno et al., 1999)

Additional Descriptive Data

Rok transcripts are widely distributed in embryos and are uniformly distributed in imaginal discs from third instar larvae.

(Mizuno et al., 1999)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

colocalizes_with apical cortex

inferred from direct assay

(Vasquez et al., 2014)

located_in apicomedial cortex

inferred from direct assay

(Chung et al., 2017, Mason et al., 2013)

located_in cell cortex

inferred from direct assay

(Tsankova et al., 2017)

located_in cell-cell contact zone

inferred from direct assay

(Kim et al., 2015)

located_in cell-cell junction

inferred from direct assay

(Beati et al., 2018)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rok in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Rok

View exonic expression by tissue for Dmel\Rok

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43916/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026181

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026181

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026181

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9774

Flygut - An atlas of the Drosophila adult midgut

FBgn0026181

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 54 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Rok

Transgenic constructs containing regulatory region of Rok

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene duplicated in

Tp(1;2)r⁺75c

(Winter et al., 2001)

Gene partially disrupted in

Df(1)YO17

(Manning et al., 2013)

Inferred from location ( 27 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^69B

Rok^cat.UAS.cVa

lethal, with Scer\GAL4^Act5C.PU

Rok^cat.UAS.cVa

lethal, with Scer\GAL4^da.G32

Rok^cat.UAS.cVa

lethal, with Scer\GAL4^en-e16E

Rok^cat.UAS.cVa

lethal, with Scer\GAL4^insc-Mz1407

Rok^cat.UAS.cVa

lethal, with Scer\GAL4^LE

Rok^cat.UAS.cVa

lethal, with Scer\GAL4^prd.RG1

Rok^cat.UAS.cVa

lethal, with Scer\GAL4^Tub.PU

Rok^cat.UAS.cVa

lethal | recessive

Rok¹

lethal - all die before end of larval stage | recessive

Rok²

lethal - all die before end of pupal stage, with Scer\GAL4^da.G32

Rok^CAT.UAS

lethal - all die before end of pupal stage, with Scer\GAL4^GMR.PU

Rok^5SA.UAS

lethal - all die during embryonic stage, with Scer\GAL4^arm.PS

Rok^UAS.cMa

partially lethal - majority die, with Scer\GAL4^elav.PU

Rok^cat.UAS.cVa

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Rok^GD1522

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Rok^GD1522

viable, with Scer\GAL4^Cy6

Rok^cat.UAS.cVa

viable, with Scer\GAL4^Mef2.PR

Rok^GD1522

viable, with Scer\GAL4^tin.CΔ4

Rok^GD1522

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

female sterile | germline clone

Other Phenotypes

Allele

abnormal axis specification | embryonic stage 15 | male limited

Rok²

abnormal axis specification | embryonic stage 16 | male limited

Rok²

abnormal axis specification | embryonic stage 17 | male limited

Rok²

abnormal cell polarity | somatic clone, with Scer\GAL4^FRT.Act5C

Rok^CAT.UAS

abnormal cell shape

Rok^unspecified

abnormal cell shape | germline clone

Rok²

abnormal cell shape | P-stage, with Scer\GAL4^hh-Gal4

abnormal cell shape | somatic clone

Rok²

abnormal neuroanatomy, with Scer\GAL4^ey-OK107

Rok^CAT.UAS

abnormal neuroanatomy | conditional, with Scer\GAL4^Or22a.PU

Rok^CAT-KG.UAS

abnormal neuroanatomy | recessive | somatic clone

Rok²

abnormal planar polarity

abnormal planar polarity, with Scer\GAL4^pnr-MD237

Rok^GD1522

abnormal planar polarity | recessive | somatic clone

Rok²

abnormal planar polarity | somatic clone

Rok²

abnormal wound healing | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

decreased fecundity | female | germline clone

Rok²

increased cell death

Rok^cat.GMR

increased cell death | somatic clone | third instar larval stage, with Scer\GAL4^Tub.PU

Rok^CAT.UAS

some die during embryonic stage, with Scer\GAL4^arm.PS

Rok^UAS.cMa

some die during larval stage | recessive

Rok²

some die during pupal stage, with Scer\GAL4^da.G32

Rok^CAT.UAS

some die during pupal stage, with Scer\GAL4^pnr-MD237

Rok^GD1522

visible

Rok^cat.GMR

visible, with Scer\GAL4^Bx-MS1096

visible, with Scer\GAL4^nub-AC-62

visible, with Scer\GAL4^pnr-MD237

Rok^GD1522

visible | adult stage, with Scer\GAL4^sr-md710

Rok^KK107802

visible | recessive | somatic clone

Rok²

wild-type

Rok^αTub84B.PW

Phenotype manifest in

Allele

actin cytoskeleton | P-stage, with Scer\GAL4^hh-Gal4

Rok^KK107802

actomyosin contractile ring | embryonic stage 5 | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}

Rok^RNAi.UAS

adherens junction | somatic clone

Rok²

apical part of cell | P-stage, with Scer\GAL4^hh-Gal4

Rok^KK107802

contractile ring | somatic clone

Rok²

cortical actin cytoskeleton | P-stage, with Scer\GAL4^hh-Gal4

Rok^CAT.UAS

crossvein, with Scer\GAL4^en-e16E

Rok^cat.UAS.cVa

dorsal appendage | germline clone

egg, with Scer\GAL4^nanos.PU

Rok^UAS.Tag:HA

egg | germline clone

egg chamber | conditional, with Scer\GAL4^hs.PU

Rok^VDRC.cUa

egg chamber | somatic clone

Rok²

embryonic/first instar larval cuticle | dorsal, with Scer\GAL4^unspecified

Rok^UAS.cMa

embryonic/larval anterior midgut | embryonic stage 15 | male limited

Rok²

embryonic/larval anterior midgut | embryonic stage 16 | male limited

Rok²

embryonic/larval anterior midgut | embryonic stage 17 | male limited

Rok²

embryonic/larval epidermis, with Scer\GAL4^NP0056

Rok^CAT.UAS

embryonic/larval plasmatocyte | third instar larval stage, with Scer\GAL4^Hml.Δ

Rok^{CA.UASp.Tag:HA}

embryonic leading edge cell, with Scer\GAL4^69B

Rok^UAS.cMa

embryonic proventriculus | embryonic stage 15 | male limited

Rok²

embryonic proventriculus | embryonic stage 16 | male limited

Rok²

embryonic proventriculus | embryonic stage 17 | male limited

Rok²

epithelial cell

Rok^unspecified

epithelial cell | P-stage, with Scer\GAL4^hh-Gal4

epithelium | somatic clone

Rok²

exuvial fluid | pupal stage, with Scer\GAL4^sr-md710

Rok^KK107802

eye

Rok^cat.GMR

eye, with Scer\GAL4^69B

Rok^cat.UAS.cVa

eye, with Scer\GAL4^ey.PU

Rok^cat.UAS.cVa

eye, with Scer\GAL4^GMR.PU

eye-antennal disc | somatic clone | third instar larval stage, with Scer\GAL4^Tub.PU

eye disc morphogenetic furrow | somatic clone

Rok²

eye photoreceptor cell | somatic clone

Rok²

eye photoreceptor cell | somatic clone | increased number

Rok²

eye photoreceptor cell | somatic clone | third instar larval stage, with Scer\GAL4^Tub.PU

Rok^CAT.UAS

filamentous actin & nurse cell | germ-line clone

filamentous actin & oocyte | germ-line clone

follicle cell | somatic clone

Rok²

hub cell | somatic clone

Rok²

larval dorsal hair, with Scer\GAL4^unspecified

Rok^UAS.cMa

larval tracheocyte | larval stage, with Scer\GAL4^btl.PS

Rok^KK107802

mesonotum, with Scer\GAL4^pnr-MD237

Rok^GD1522

mushroom body & axon | somatic clone

Rok²

nucleus

Rok^unspecified

nurse cell | germline clone

Rok²

nurse cell ring canal | germline clone

Rok²

olfactory receptor neuron | conditional, with Scer\GAL4^Or22a.PU

Rok^CAT-KG.UAS

ommatidium | somatic clone

Rok²

oocyte | germline clone

Rok²

oocyte | somatic clone, with Scer\GAL4^FRT.Act5C

Rok^CAT.UAS

photoreceptor neuron

Rok^cat.GMR

plasma membrane & oocyte | germ-line clone

presumptive embryonic salivary gland

Rok²

presumptive embryonic salivary gland, with Scer\GAL4^arm.PS

Rok^VDRC.cUa

pupa, with Scer\GAL4^hh-Gal4

Rok^KK107802

pupal cuticle, with Scer\GAL4^hh-Gal4

Rok^KK107802

stress fiber | third instar larval stage, with Scer\GAL4^Hml.Δ

Rok^{CA.UASp.Tag:HA}

tracheocyte | P-stage, with Scer\GAL4^btl.PS

Rok^KK107802

vertical lobe of adult mushroom body, with Scer\GAL4^ey-OK107

Rok^CAT.UAS

wing, with Scer\GAL4^Bx-MS1096

wing, with Scer\GAL4^nub-AC-62

wing, with Scer\GAL4^sr-md710

Rok^KK107802

wing disc | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

Rok^UAS.cMa

wing disc | third instar larval stage, with Scer\GAL4^Bx-MS1096

Rok^UAS.cMa

wing disc | third instar larval stage, with Scer\GAL4^ptc-559.1

Rok^UAS.cMa

wing hair | cell autonomous | somatic clone | increased number

Rok²

wing hair | somatic clone | increased number

Rok²

wing margin, with Scer\GAL4^Cy6

Rok^cat.UAS.cVa

yolk granule | germline clone

Rok²

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (35)

Hsap\ROCK2

14 of 14

Yes

Hsap\ROCK1

13 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (20)

Rnor\Rock2

13 of 14

Yes

Rnor\Rock1

12 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (21)

Mmus\Rock2

14 of 14

Yes

Mmus\Rock1

13 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (24)

Xtro\rock1

10 of 13

Yes

Xtro\rock2

7 of 13

Yes

5 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (28)

Drer\rock2a

14 of 14

Yes

Drer\rock1

12 of 14

Yes

Drer\rock2b

12 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Drer\LOC101883172

1 of 14

Yes

Drer\LOC101883269

1 of 14

Yes

Drer\LOC101884327

1 of 14

Yes

Drer\LOC101886143

1 of 14

Yes

Drer\LOC108182331

1 of 14

Yes

Drer\LOC110438182

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\let-502

13 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (18)

Agam\AgaP_AGAP000406

12 of 12

Yes

3 of 12

3 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (20)

Atha\AT1G03920

2 of 13

Yes

Atha\AT1G30640

2 of 13

Yes

Atha\AT2G19400

2 of 13

Yes

Atha\AT2G20470

2 of 13

Yes

Atha\AT3G23310

2 of 13

Yes

Atha\AT4G14350

2 of 13

Yes

Atha\AT4G33080

2 of 13

Yes

Atha\AT5G09890

2 of 13

Yes

Atha\AGC2-1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\IRE

1 of 13

Atha\KIN11

1 of 13

Atha\PHOT2

1 of 13

Yes

Atha\PID2

1 of 13

Atha\PK1

1 of 13

Atha\S6K2

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (12)

Scer\CBK1

1 of 13

Yes

Scer\DBF2

1 of 13

Yes

Scer\DBF20

1 of 13

Yes

Scer\FPK1

1 of 13

Yes

Scer\KIN82

1 of 13

Yes

Scer\RIM15

1 of 13

Yes

Scer\SAT4

1 of 13

Yes

Scer\TPK1

1 of 13

Yes

Scer\TPK2

1 of 13

Yes

Scer\TPK3

1 of 13

Yes

Scer\YPK1

1 of 13

Yes

Scer\YPK2

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\mug27

1 of 12

Yes

Spom\orb6

1 of 12

Yes

Spom\sid2

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Rok. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (16)

gek

5 of 13

sti

5 of 13

trc

2 of 13

wts

2 of 13

Akt

1 of 13

CG4839

1 of 13

dop

1 of 13

for

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

S6k

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Rok^CAT.UAS

model of cancer

CEA with Ras85D^G12V.UAS

(Khoo et al., 2013)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Rok^HMS01311

ameliorates Charcot-Marie-Tooth disease type 4B1

modeled by mtm^G447D

(Hu et al., 2022)

Rok¹

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

Rok^GD1522

ameliorates cancer

modeled by RhoGEF2^RE.UAS, Raf^UAS.F179

(Khoo et al., 2013)

exacerbates carcinoma

modeled by scrib¹

(Kong et al., 2022)

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ROCK2; Rho associated coiled-coil containing protein kinase 2

14 of 14

604002

ROCK1; Rho associated coiled-coil containing protein kinase 1

13 of 14

601702

CDC42BPA; CDC42 binding protein kinase alpha

3 of 14

603412

CDC42BPB; CDC42 binding protein kinase beta

3 of 14

614062

CHILTON-OKUR-CHUNG NEURODEVELOPMENTAL SYNDROME; CHOCNS

CDC42BPG; CDC42 binding protein kinase gamma

3 of 14

613991

CIT; citron rho-interacting serine/threonine kinase

3 of 14

605629

MICROCEPHALY 17, PRIMARY, AUTOSOMAL RECESSIVE; MCPH17

primary autosomal recessive microcephaly 17

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Rok - Drp1

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation

(Qu et al., 2022)

Rok - Rab5

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Rok - Rho1

two hybrid, pull down, western blot, autoradiography

(Nahm et al., 2006, Winter et al., 2001, Mizuno et al., 1999)

Rok - Shrm

pull down, molecular weight estimation by staining, comigration in non denaturing gel electrophoresis, fluorescent resonance energy transfer, fluorescence technology

(Mohan et al., 2012, Bolinger et al., 2010)

Rok - aurA

enzymatic study, autoradiography

(Moon and Matsuzaki, 2013)

Rok - cmb

enzymatic study, molecular weight estimation by staining, autoradiography

(Fagan et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Rok

enhanceable

dia

(Warner and Longmore, 2009)

Rok

suppressible

dia

(Verdier et al., 2006)

Rok

suppressible

egr

(Khoo et al., 2013)

Rok|Drak

suppressible

flw

(Neubueser and Hipfner, 2010)

Rok

suppressible

Graf

(Sharma and Rikhy, 2021)

Rok

suppressible

hts

(Verdier et al., 2006)

Rok

suppressible

jub

(Rauskolb et al., 2014)

Rok

enhanceable

jub

(Rauskolb et al., 2014)

Rok

enhanceable

LIMK1

(Verdier et al., 2006)

Rok

suppressible

Mbs

(Lee and Treisman, 2004)

Rok|zip

suppressible

Mbs

(Mizuno et al., 2002)

Rok

enhanceable

Ras85D

(Khoo et al., 2013)

Rok

suppressible

Rho1

(Verdier et al., 2006)

Rok

suppressible

sqh

(Rauskolb et al., 2014, Winter et al., 2001)

suppressible

(Kim et al., 2015)

suppressible

(Neubueser and Hipfner, 2010)

Rok

suppressible

zip

(Moon and Matsuzaki, 2013, Verdier et al., 2006, Mizuno et al., 2002)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

aurA

suppressible

Rok

(Moon and Matsuzaki, 2013)

Cln3

suppressible

Rok

(Llavero Hurtado et al., 2017)

cmb

enhanceable

Rok

(Fagan et al., 2014)

crb

suppressible

Rok

(Flores-Benitez and Knust, 2015)

dsh

suppressible

Rok

(Winter et al., 2001)

dsh

enhanceable

Rok

(Winter et al., 2001)

suppressible

(Hu et al., 2022)

suppressible

(Hu et al., 2022)

suppressible

Rok

(Winter et al., 2001)

Graf

suppressible

Rok

(Sharma and Rikhy, 2021)

suppressible

Rok

(Müller et al., 2005)

LIMK1

suppressible

Rok

(Chen et al., 2004, Ng and Luo, 2004)

enhanceable

(Ng and Luo, 2004)

suppressible

(Lee and Treisman, 2004)

Moe

suppressible

Rok

(Speck et al., 2003)

suppressible

(Hu et al., 2022)

suppressible

(Yan et al., 2009)

suppressible

(Echard and O'Farrell, 2003)

Pi3K92E|btl::Egfr

suppressible

Rok

(Chen et al., 2019)

suppressible

Rok

(Jenny et al., 2003)

enhanceable

(Nie et al., 2014)

suppressible

(Bardet et al., 2013)

qsm

suppressible

Rok

(Chu and Hayashi, 2021)

suppressible

(Tan et al., 2003)

suppressible

(Khoo et al., 2013)

Ras85D|p53|CycE|Med

suppressible

Rok

(Sekiya et al., 2023)

suppressible

(Xu et al., 2008)

suppressible

(Khoo et al., 2013)

enhanceable

Rok

(Chen et al., 2004)

Shrm

suppressible

Rok

(Hildebrand et al., 2021, Bolinger et al., 2010)

sqh|aurA

suppressible

Rok

(Moon and Matsuzaki, 2013)

tow

enhanceable

Rok

(Chung et al., 2007)

tow

suppressible

Rok

(Chung et al., 2007)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68714

DroID - A comprehensive database of gene and protein interactions.

FBgn0026181

MIST (genetic) - An integrated Molecular Interaction Database

43916

MIST (protein-protein) - An integrated Molecular Interaction Database

43916

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

TGF-beta signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q961D4

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-54

Cytogenetic map

14F2-14F4

Sequence location

X:16,624,012..16,637,414 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

14F2-14F4

Limits computationally determined from genome sequence between P{EP}EP1547^EP1547 and P{EP}CG4928^EP1341

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

15A-15A

(Mizuno, 1999.5.13, Winter et al., 1999)

Experimentally Determined Recombination Data

Location

1-54

(FlyBase, 2016)

1-55.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (25)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

52288

P{sqh-GFP-Rok}10, w^*

52289

w^*; P{sqh-GFP-Rok}30

6671

w^*; P{UAS-Rok.CAT-KG}3

6672

P{αTub84B-Rok.W}2A, w^*

6670

w^*; P{UAS-Rok.CAT-KG}2B1

52290

w^*; P{UASp-Rok.RBD-GFP}30

6667

P{UAS-Rok.CAT}2.1, y¹ w^*

11240

9774R-2

9774R-3

v104675

v3793

w¹¹¹⁸; P{GD1522}v3793

More stocks available...

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (30)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD15203

Other clones

FI04037

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0026181

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0026181

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Qin et al., 2018, Moon and Matsuzaki, 2013)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

rok is required for follicle cell and egg chamber shape.

(Wang and Riechmann, 2007)

dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.

(Echard et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

(Rogers et al., 2003)

rok works downstream of fz/dsh to mediate a subset of the planar cell polarity (PCP) response, regulating the number but not orientation of wing hairs and the rotation but not chirality of photoreceptor clusters.

(Winter et al., 2001)

Relationship to Other Genes

Source for database merge of

Source for merge of: rok Rhk

(Winter et al., 2001)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Rok rok

(FlyBase, 2009-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (34)

Reported As

Symbol Synonym

CG9774

(Hirschhäuser et al., 2021, Metwally et al., 2019, Çiçek et al., 2016, Hosono et al., 2015, Schertel et al., 2013, Howell et al., 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Rogers et al., 2003, Morrison et al., 2000)

DROK

(Serio et al., 2010, Balasubramanian et al., 2004, Rogers et al., 2004, Rogers et al., 2003, Rogers et al., 2003, Muller and Littlewood-Evans, 2001)

DRhk

(Mizuno et al., 2002, Mizuno et al., 1999)

DRok

(Vega-Macaya et al., 2016, Verdier et al., 2006)

Drok

(Garrido-Jimenez et al., 2018, Manieu et al., 2018, Moon and Matsuzaki, 2013, Capilla et al., 2012, Gault et al., 2012, Muñoz-Soriano et al., 2012, Pataki et al., 2010, Chung et al., 2009, Todi et al., 2008, Chung et al., 2007, Escudero et al., 2007, Fiehler and Wolff, 2007, Mitonaka et al., 2007, Song et al., 2007, Verdier et al., 2006, Chung et al., 2005, Govek et al., 2005, Todi et al., 2005, Chen et al., 2004, Fanto and McNeill, 2004, Royou et al., 2004, Gonzalez, 2003, Speck et al., 2003, Strutt, 2003, Tan et al., 2003, Royou et al., 2002, Tree et al., 2002, Van Aelst and Symons, 2002, Adler and Lee, 2001, Baas and Luo, 2001, Billuart et al., 2001, Billuart et al., 2001, Cooper and Strutt, 2001, Huelsken, 2001, Strutt, 2001, Winter et al., 2001, Winter et al., 2001, Winter et al., 1999)

MRLC

(Kobb et al., 2019)

ROCK-1

(Kuranaga and Miura, 2007)

ROCK1

(Sekiya et al., 2023, Morrison et al., 2000)

ROCK2

(Wishart et al., 2012)

ROCk

(Martin, 2020)

ROK

(John and Rauzi, 2021, Lam et al., 2020, Hunter et al., 2019, Qin et al., 2017, Puram and Bonni, 2013, D'Avino et al., 2005, Veeman et al., 2003)

ROKα/β

(Petit et al., 2002)

Rhk

RhoK

(Baum, 2002)

Rock

(Roubinet et al., 2017, Warner et al., 2010, Alves-Silva et al., 2008, O'Farrell et al., 2004)

Rok

(Kamalesh et al., 2024, Kroeger et al., 2024, Mira-Osuna and Borgne, 2024, Rosa-Birriel et al., 2024, Willnow and Teleman, 2024, di Pietro et al., 2023, Floc'hlay et al., 2023, Gabbert et al., 2023, Buckley and St Johnston, 2022, Ding et al., 2022, Guru et al., 2022, Kakanj et al., 2022, Koehler et al., 2022, Kong et al., 2022, Lepeta et al., 2022, Liu et al., 2022, Rout et al., 2022, Villars et al., 2022, Bischoff et al., 2021, Carmena, 2021, Kapoor et al., 2021, Loganathan et al., 2021, Ostalé et al., 2021, Pang et al., 2021, Tavares et al., 2021, Zhang et al., 2021, Carim et al., 2020, Gheisari et al., 2020, Greig and Bulgakova, 2020, Kirkland et al., 2020, Kong and Großhans, 2020, Lin et al., 2020, Mlodzik, 2020, Oliveira da Silva et al., 2020, Perez-Vale and Peifer, 2020, Ponte et al., 2020, Sidor et al., 2020, Wang et al., 2020, Alégot et al., 2019, Balaji et al., 2019, Jiang and Harris, 2019, Jiang et al., 2019, Metwally et al., 2019, Steinhauer et al., 2019, Tetley et al., 2019, Jha et al., 2018, Richardson and Portela, 2018, Segal et al., 2018, Banisch et al., 2017, Chung et al., 2017, Curran et al., 2017, Gilmour et al., 2017, Hara, 2017, Mitrossilis et al., 2017, Tran and Ten Hagen, 2017, Bothe and Baylies, 2016, Duque and Gorfinkiel, 2016, Flores-Benitez and Knust, 2016, Loza et al., 2016, Rousso et al., 2016, Schimizzi et al., 2016, Yoo et al., 2016, Flores-Benitez and Knust, 2015, Hunter et al., 2015, Kanoh et al., 2015, Lan et al., 2015, Meserve and Duronio, 2015, Munjal et al., 2015, Xie and Martin, 2015, Abreu-Blanco et al., 2014, Ferreira et al., 2014, Kasza et al., 2014, Lammel et al., 2014, Nie et al., 2014, Simões et al., 2014, Sopko et al., 2014, Yashiro et al., 2014, Bulgakova et al., 2013, Parkhurst, 2013.10.2, Gates, 2012, Krajcovic and Minden, 2012, Roper, 2012, Muyskens and Guillemin, 2011, Sun et al., 2011, Zacharogianni et al., 2011, Zhang et al., 2011, Castoreno et al., 2010, Simões et al., 2010, Warner et al., 2010, Yan et al., 2009, Hickson and O'Farrell, 2008, Koelsch and Leptin, 2008, Kunda et al., 2008, Ng, 2008, Simone and DiNardo, 2008, Williams et al., 2007, Dean and Spudich, 2006, Hickson et al., 2006, Nahm et al., 2006, Talbot and VanBerkum, 2006, Hickson and O'Farrell, 2005, Naim et al., 2004, Ng and Luo, 2004)

Rok/ROCK

(Yin et al., 2013)

dROK

(Founounou et al., 2021, Mirkovic et al., 2011, Mlodzik, 2002)

dRok

(Jawkar and Nongthomba, 2020, Thuveson et al., 2019, Weber et al., 2012, Bolinger et al., 2010, Mirkovic and Mlodzik, 2006, Verdier et al., 2003)

drok

(Bourouliti and Skoulakis, 2022, Lesch and Page, 2012, Jenny, 2011, Bayer et al., 2003, Jenny et al., 2003)

rock

(Coravos and Martin, 2016)

rok

(Hu et al., 2022, Bonello et al., 2021, Lebo et al., 2021, Aguilar-Aragon et al., 2020, Deng et al., 2020, Pulido Companys et al., 2020, Chen et al., 2019, Lee and Chen, 2019, Al-Ramahi et al., 2018, Córdoba and Estella, 2018, Tsoumpekos et al., 2018, Zhang et al., 2018, Pinheiro et al., 2017, Tsankova et al., 2017, Zihni et al., 2017, Aigouy and Le Bivic, 2016, Chang et al., 2016, Hunter et al., 2015, Kim et al., 2015, Bilousov et al., 2014, Fagan et al., 2014, Georgieva et al., 2014, Gersten et al., 2014, Muliyil and Narasimha, 2014, Rauskolb et al., 2014, Vasquez et al., 2014, Bardet et al., 2013, Das et al., 2013, Herszterg et al., 2013, Khoo et al., 2013, Manning et al., 2013, Morais-de-Sá and Sunkel, 2013, Nakajima et al., 2013, Sander et al., 2013, Schertel et al., 2013, Gates, 2012, Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Robertson et al., 2012, Vlachos and Harden, 2011, Xu et al., 2011, Djiane and Mlodzik, 2010, Kadandale et al., 2010, Neisch et al., 2010, Neubueser and Hipfner, 2010, Okumura et al., 2010, Popodi et al., 2010-, Cook and Levis, 2009.12.21, Warner and Longmore, 2009, Loh et al., 2008, Okumura et al., 2008, Xu et al., 2008, Corrigall et al., 2007, Ninov et al., 2007, Wang and Riechmann, 2007, Hickson et al., 2006, FlyBase, 1992-)

Name Synonyms

DRho-kinase

(Mizuno et al., 2002, Mizuno et al., 1999)

Drosophila rho-associated kinase

(Gault et al., 2012)

RHO kinase

(Adler, 2002)

ROCK

(Li et al., 2024, He et al., 2010, Warner and Longmore, 2009)

Rho Kinase

(Krajcovic and Minden, 2012)

Rho kinase

(Córdoba and Estella, 2018, Munjal et al., 2015, Lammel et al., 2014, Khoo et al., 2013, Peters and Rogers, 2013, Gates, 2012, Fauvarque and Williams, 2011, Jenny, 2011, Zacharogianni et al., 2011, Castoreno et al., 2010, Neisch et al., 2010, Yan et al., 2009, Wang and Riechmann, 2007, Wang and Riechmann, 2007, Dean and Spudich, 2006, Talbot and VanBerkum, 2006, D'Avino et al., 2005)

Rho-associated kinase

(Tran and Ten Hagen, 2017, Rousso et al., 2016, Hunter et al., 2015, Song et al., 2007, Winter et al., 2001)

Rho-associated protein kinase

(Abreu-Blanco et al., 2014)

Rho-kinase

(Martin, 2020, Paré and Zallen, 2020, Simões et al., 2014, Bardet et al., 2013, Hazelett et al., 2012, Howell et al., 2012, Weber et al., 2012, Simões et al., 2010, Simone and DiNardo, 2008, Todi et al., 2008, Williams et al., 2007, Hickson et al., 2006, Mizuno et al., 1999, Winter et al., 1999)

RhoA kinase

(Escudero et al., 2007)

Rock

(Fujisawa et al., 2020)

rho kinase

(Lesch and Page, 2012, Dean et al., 2005)

rho-associated kinase

(Gault et al., 2012)

Secondary FlyBase IDs

FBgn0028698

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 77 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43916

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VXE3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VXE3

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43916/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026181

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026181

FlyMine - An integrated database for Drosophila genomics

FBgn0026181

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9774

MARRVEL_MODEL - MARRVEL (model organism gene)

43916

Linkouts

BioGRID - A database of protein and genetic interactions.

68714

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0026181

DroID - A comprehensive database of gene and protein interactions.

FBgn0026181

DRSC - Results frm RNAi screens

FBgn0026181

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Rok_1
Rok_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026181

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0026181

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9774

Flygut - An atlas of the Drosophila adult midgut

FBgn0026181

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0026181

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014705

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

TGF-beta signaling pathway

MIST (genetic) - An integrated Molecular Interaction Database

43916

MIST (protein-protein) - An integrated Molecular Interaction Database

43916

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q961D4

References (388)

The following external sites may use different assemblies or annotations than FlyBase.

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