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Gene Dmel\prominin-like

General Information
Symbol	Dmel\prominin-like	Species	D. melanogaster
Name	prominin-like	Annotation symbol	CG7740
Feature type	protein_coding_gene	FlyBase ID	FBgn0026189
Gene Model Status	Current	Stock availability	10 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	63B2-63B3	Sequence location	3L:3,114,557..3,127,723 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene prominin-like is referred to in FlyBase by the symbol Dmel\prominin-like (CG7740, FBgn0026189). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 9 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Prominin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-18 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1641333_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of prominin-like. Gene sequence location is 3L:3114557..3127723.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN23282 HFA08733
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 63B2-63B3   Limits computationally determined from genome sequence between P{PZ}l(3)0680306803 and P{PZ}kst01318
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\prominin-like for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone LD23965 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) prominin-like-RA FBtr0073120  NM_167986   4106   1013 prominin-like-RB FBtr0073118  NM_167987   4764   1013 prominin-like-RC FBtr0073119  NM_139513   3827   1013 prominin-like-RD FBtr0306258     4704   993
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein prominin-like-PA   FBpp0072982   115.1   1013   7.10     NP_728809   AAF47716 prominin-like-PB   FBpp0072980   115.1   1013   7.10     NP_728810   AAN11530 prominin-like-PC   FBpp0072981   115.1   1013   7.10     NP_647770   AAN11531 prominin-like-PD   FBpp0297368   112.7   993   7.31
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Prominin (IPR008795)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441662   AA802877   AA817301   AA820383   AE014296 AAF47716   AE014296 AAN11530   AE014296 AAN11531   AF127935 AAD22487   AF197345 AAF07212   AI455409   AI543037   AI544245   AI946676   AW941267   AY061324 AAL28872   BF486667   BF488864   BF489371   BF491279   BF496021   BF497327   BF499027   BF502294   BF505622   BG638315   BI229341   BI235318   BI605395   BI619690   BI620374   BI620839   BI627481   BP550031   BP551126   BT003602 AAO39605   BT031128   CA803312   CA803547   CA804143   CK131668   CK661370   CO154556   CO188904   CO190289   CO190806   CO196598   CO266273   CO272084   CO274178   CO274380   CO275333   CO275387   CO275520   CO281078   CO283149   CO283283   CO287451   CO293420   CO293989   CO296119   CO296672   CO298973   CO301316   CO304761   CO314754   CO315676   CO317078   CO317257   CO322186   CO323857   CO327135   CO328456   CO333118   CO344094   CZ469140   CZ469201   CZ481188   CZ485986   EC051170   EC051681   EC052702   EC053671   EC054159   EC055714   EC072178   EC074519   EC079948   EC081049   EC083252   EC083507   EC084511   EC084606   EC085429   EC087213   EC089201   EC195370   EC204860   EC209439   EC212700   EC220998   EC222547   EC225856   EC226113   EC227979   EC233976   EC238250   EC244043   EC244651   EC247628   EC249910   EC249923   EC251913   EC255059   EC255425   EC259332   EC263774   ES690069   ES690121   GH953150   GH954743   GH968089   GH974405
UniProtKB/Swiss-Prot	P82295
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0026189    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0026189 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-18 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0026189 expression level Developmental Stage   Expression Level embryo 00-02hr    1737 embryo 02-04hr    2284 embryo 04-06hr    2820 embryo 06-08hr    4541 embryo 08-10hr    5750 embryo 10-12hr    4706 embryo 12-14hr    6454 embryo 14-16hr    4533 embryo 16-18hr    2988 embryo 18-20hr    2309 embryo 20-22hr    2283 embryo 22-24hr    2588 larva L1    2016 larva L2    1346 larva L3 12hr old    836 larva L3 puffstage 1-2    1249 larva L3 puffstage 3-6    2533 larva L3 puffstage 7-9    3824 white prepupae new    5264 white prepupae 12hr    8003 white prepupae 24hr    8637 pupae 2d postWPP    7269 pupae 3d postWPP    5799 pupae 4d postWPP    2359 adult male 01day    2773 adult male 05day    3245 adult male 30day    3218 adult female 01day    988 adult female 05day    1059 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1737) embryo 02-04hr  (2284) embryo 04-06hr  (2820) embryo 06-08hr  (4541) embryo 08-10hr  (5750) embryo 10-12hr  (4706) embryo 12-14hr  (6454) embryo 14-16hr  (4533) embryo 16-18hr  (2988) embryo 18-20hr  (2309) embryo 20-22hr  (2283) embryo 22-24hr  (2588) larva L1  (2016) larva L2  (1346) larva L3 12hr old  (836) larva L3 puffstage 1-2  (1249) larva L3 puffstage 3-6  (2533) larva L3 puffstage 7-9  (3824) white prepupae new  (5264) white prepupae 12hr  (8003) white prepupae 24hr  (8637) pupae 2d postWPP  (7269) pupae 3d postWPP  (5799) pupae 4d postWPP  (2359) adult male 01day  (2773) adult male 05day  (3245) adult male 30day  (3218) adult female 01day  (988) adult female 05day  (1059) adult female 30day  (1095) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1737) embryo 02-04hr  (2284) embryo 04-06hr  (2820) embryo 06-08hr  (4541) embryo 08-10hr  (5750) embryo 10-12hr  (4706) embryo 12-14hr  (6454) embryo 14-16hr  (4533) embryo 16-18hr  (2988) embryo 18-20hr  (2309) embryo 20-22hr  (2283) embryo 22-24hr  (2588) larva L1  (2016) larva L2    1346 larva L3 12hr old    836 larva L3 puffstage 1-2    1249 larva L3 puffstage 3-6  (2533) larva L3 puffstage 7-9  (3824) white prepupae new  (5264) white prepupae 12hr  (8003) white prepupae 24hr  (8637) pupae 2d postWPP  (7269) pupae 3d postWPP  (5799) pupae 4d postWPP  (2359) adult male 01day  (2773) adult male 05day  (3245) adult male 30day  (3218) adult female 01day    988 adult female 05day    1059 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1737 embryo 02-04hr    2284 embryo 04-06hr    2820 embryo 06-08hr    4541 embryo 08-10hr    5750 embryo 10-12hr    4706 embryo 12-14hr    6454 embryo 14-16hr    4533 embryo 16-18hr    2988 embryo 18-20hr    2309 embryo 20-22hr    2283 embryo 22-24hr    2588 larva L1    2016 larva L2    1346 larva L3 12hr old    836 larva L3 puffstage 1-2    1249 larva L3 puffstage 3-6    2533 larva L3 puffstage 7-9    3824 white prepupae new    5264 white prepupae 12hr    8003 white prepupae 24hr    8637 pupae 2d postWPP    7269 pupae 3d postWPP    5799 pupae 4d postWPP    2359 adult male 01day    2773 adult male 05day    3245 adult male 30day    3218 adult female 01day    988 adult female 05day    1059 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1737 embryo 02-04hr    2284 embryo 04-06hr    2820 embryo 06-08hr    4541 embryo 08-10hr    5750 embryo 10-12hr    4706 embryo 12-14hr    6454 embryo 14-16hr    4533 embryo 16-18hr    2988 embryo 18-20hr    2309 embryo 20-22hr    2283 embryo 22-24hr    2588 larva L1    2016 larva L2    1346 larva L3 12hr old    836 larva L3 puffstage 1-2    1249 larva L3 puffstage 3-6    2533 larva L3 puffstage 7-9    3824 white prepupae new    5264 white prepupae 12hr    8003 white prepupae 24hr    8637 pupae 2d postWPP    7269 pupae 3d postWPP    5799 pupae 4d postWPP    2359 adult male 01day    2773 adult male 05day    3245 adult male 30day    3218 adult female 01day    988 adult female 05day    1059 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0026189 expression level Developmental Stage   Expression Level embryo 00-02hr    1737 embryo 02-04hr    2284 embryo 04-06hr    2820 embryo 06-08hr    4541 embryo 08-10hr    5750 embryo 10-12hr    4706 embryo 12-14hr    6454 embryo 14-16hr    4533 embryo 16-18hr    2988 embryo 18-20hr    2309 embryo 20-22hr    2283 embryo 22-24hr    2588 larva L1    2016 larva L2    1346 larva L3 12hr old    836 larva L3 puffstage 1-2    1249 larva L3 puffstage 3-6    2533 larva L3 puffstage 7-9    3824 white prepupae new    5264 white prepupae 12hr    8003 white prepupae 24hr    8637 pupae 2d postWPP    7269 pupae 3d postWPP    5799 pupae 4d postWPP    2359 adult male 01day    2773 adult male 05day    3245 adult male 30day    3218 adult female 01day    988 adult female 05day    1059 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1737) embryo 02-04hr  (2284) embryo 04-06hr  (2820) embryo 06-08hr  (4541) embryo 08-10hr  (5750) embryo 10-12hr  (4706) embryo 12-14hr  (6454) embryo 14-16hr  (4533) embryo 16-18hr  (2988) embryo 18-20hr  (2309) embryo 20-22hr  (2283) embryo 22-24hr  (2588) larva L1  (2016) larva L2  (1346) larva L3 12hr old  (836) larva L3 puffstage 1-2  (1249) larva L3 puffstage 3-6  (2533) larva L3 puffstage 7-9  (3824) white prepupae new  (5264) white prepupae 12hr  (8003) white prepupae 24hr  (8637) pupae 2d postWPP  (7269) pupae 3d postWPP  (5799) pupae 4d postWPP  (2359) adult male 01day  (2773) adult male 05day  (3245) adult male 30day  (3218) adult female 01day  (988) adult female 05day  (1059) adult female 30day  (1095) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1737 embryo 02-04hr  2284 embryo 04-06hr  (2820) embryo 06-08hr  (4541) embryo 08-10hr  (5750) embryo 10-12hr  (4706) embryo 12-14hr  (6454) embryo 14-16hr  (4533) embryo 16-18hr  (2988) embryo 18-20hr  2309 embryo 20-22hr  2283 embryo 22-24hr  (2588) larva L1  2016 larva L2    1346 larva L3 12hr old    836 larva L3 puffstage 1-2    1249 larva L3 puffstage 3-6  (2533) larva L3 puffstage 7-9  (3824) white prepupae new  (5264) white prepupae 12hr  (8003) white prepupae 24hr  (8637) pupae 2d postWPP  (7269) pupae 3d postWPP  (5799) pupae 4d postWPP  2359 adult male 01day  (2773) adult male 05day  (3245) adult male 30day  (3218) adult female 01day    988 adult female 05day    1059 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1737 embryo 02-04hr    2284 embryo 04-06hr    2820 embryo 06-08hr    4541 embryo 08-10hr    5750 embryo 10-12hr    4706 embryo 12-14hr    6454 embryo 14-16hr    4533 embryo 16-18hr    2988 embryo 18-20hr    2309 embryo 20-22hr    2283 embryo 22-24hr    2588 larva L1    2016 larva L2    1346 larva L3 12hr old    836 larva L3 puffstage 1-2    1249 larva L3 puffstage 3-6    2533 larva L3 puffstage 7-9    3824 white prepupae new    5264 white prepupae 12hr    8003 white prepupae 24hr    8637 pupae 2d postWPP    7269 pupae 3d postWPP    5799 pupae 4d postWPP    2359 adult male 01day    2773 adult male 05day    3245 adult male 30day    3218 adult female 01day    988 adult female 05day    1059 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1737 embryo 02-04hr    2284 embryo 04-06hr    2820 embryo 06-08hr    4541 embryo 08-10hr    5750 embryo 10-12hr    4706 embryo 12-14hr    6454 embryo 14-16hr    4533 embryo 16-18hr    2988 embryo 18-20hr    2309 embryo 20-22hr    2283 embryo 22-24hr    2588 larva L1    2016 larva L2    1346 larva L3 12hr old    836 larva L3 puffstage 1-2    1249 larva L3 puffstage 3-6    2533 larva L3 puffstage 7-9    3824 white prepupae new    5264 white prepupae 12hr    8003 white prepupae 24hr    8637 pupae 2d postWPP    7269 pupae 3d postWPP    5799 pupae 4d postWPP    2359 adult male 01day    2773 adult male 05day    3245 adult male 30day    3218 adult female 01day    988 adult female 05day    1059 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0026189    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0026189 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0026189 expression level Tissue   Expression Level Larval Central Nervous System    216.95 Larval Midgut no informative data Larval Hindgut    67.1 Larval Malpighian Tubules    139.4 Larval Fat Body    41.6 Larval Salivary Gland    56.8 Larval Trachea    79.125 Larval Carcass    41.675 Adult Head    39.3 Adult Eye no informative data Adult Brain    162.5 Adult Thoracic-Abdominal Ganglion    82.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    32.3 Adult Malpighian Tubules    217.5 Adult Fat Body    29.7 Adult Salivary Gland no informative data Adult Heart    19.7 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    40.5 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    216.95 Larval Midgut no informative data Larval Hindgut    67.1 Larval Malpighian Tubules    139.4 Larval Fat Body    41.6 Larval Salivary Gland    56.8 Larval Trachea    79.125 Larval Carcass    41.675 Adult Head    39.3 Adult Eye no informative data Adult Brain    162.5 Adult Thoracic-Abdominal Ganglion    82.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    32.3 Adult Malpighian Tubules    217.5 Adult Fat Body    29.7 Adult Salivary Gland no informative data Adult Heart    19.7 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    40.5 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    216.95 Larval Midgut no informative data Larval Hindgut    67.1 Larval Malpighian Tubules    139.4 Larval Fat Body    41.6 Larval Salivary Gland    56.8 Larval Trachea    79.125 Larval Carcass    41.675 Adult Head    39.3 Adult Eye no informative data Adult Brain    162.5 Adult Thoracic-Abdominal Ganglion    82.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    32.3 Adult Malpighian Tubules    217.5 Adult Fat Body    29.7 Adult Salivary Gland no informative data Adult Heart    19.7 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    40.5 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    216.95 Larval Midgut no informative data Larval Hindgut    67.1 Larval Malpighian Tubules    139.4 Larval Fat Body    41.6 Larval Salivary Gland    56.8 Larval Trachea    79.125 Larval Carcass    41.675 Adult Head    39.3 Adult Eye no informative data Adult Brain    162.5 Adult Thoracic-Abdominal Ganglion    82.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    32.3 Adult Malpighian Tubules    217.5 Adult Fat Body    29.7 Adult Salivary Gland no informative data Adult Heart    19.7 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    40.5 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0026189 expression level Tissue   Expression Level Larval Central Nervous System    216.95 Larval Midgut no informative data Larval Hindgut    67.1 Larval Malpighian Tubules    139.4 Larval Fat Body    41.6 Larval Salivary Gland    56.8 Larval Trachea    79.125 Larval Carcass    41.675 Adult Head    39.3 Adult Eye no informative data Adult Brain    162.5 Adult Thoracic-Abdominal Ganglion    82.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    32.3 Adult Malpighian Tubules    217.5 Adult Fat Body    29.7 Adult Salivary Gland no informative data Adult Heart    19.7 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    40.5 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    216.95 Larval Midgut no informative data Larval Hindgut    67.1 Larval Malpighian Tubules    139.4 Larval Fat Body    41.6 Larval Salivary Gland    56.8 Larval Trachea    79.125 Larval Carcass    41.675 Adult Head    39.3 Adult Eye no informative data Adult Brain    162.5 Adult Thoracic-Abdominal Ganglion    82.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    32.3 Adult Malpighian Tubules    217.5 Adult Fat Body    29.7 Adult Salivary Gland no informative data Adult Heart    19.7 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    40.5 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    216.95 Larval Midgut no informative data Larval Hindgut    67.1 Larval Malpighian Tubules    139.4 Larval Fat Body    41.6 Larval Salivary Gland    56.8 Larval Trachea    79.125 Larval Carcass    41.675 Adult Head    39.3 Adult Eye no informative data Adult Brain    162.5 Adult Thoracic-Abdominal Ganglion    82.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    32.3 Adult Malpighian Tubules    217.5 Adult Fat Body    29.7 Adult Salivary Gland no informative data Adult Heart    19.7 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    40.5 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    216.95 Larval Midgut no informative data Larval Hindgut    67.1 Larval Malpighian Tubules    139.4 Larval Fat Body    41.6 Larval Salivary Gland    56.8 Larval Trachea    79.125 Larval Carcass    41.675 Adult Head    39.3 Adult Eye no informative data Adult Brain    162.5 Adult Thoracic-Abdominal Ganglion    82.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    32.3 Adult Malpighian Tubules    217.5 Adult Fat Body    29.7 Adult Salivary Gland no informative data Adult Heart    19.7 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    40.5 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    39.3   NA  Eye    no informative data   NA  Brain    162.5   216.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    82.6   NA  Crop    no informative data   no informative data  Midgut    no informative data   67.1  Hindgut    32.3   139.4  Malpighian Tubules    217.5   41.6  Fat Body    29.7   56.8  Salivary Gland    no informative data   NA  Heart    19.7   79.125  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    40.5   NA  Testis    44.2   NA  Male Accessory Gland    no informative data   41.675  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026189 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7740-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of prominin-like Class Mutagen Stocks Known lesion prominin-likef03422 piggyBac transposase 2 -- prominin-likec04290 piggyBac transposase 1 -- prominin-likee03410 piggyBac transposase 1 -- prominin-likeMB08636 1 -- prominin-likeMB08988 1 -- prominin-likeMI02343 1 -- prominin-likec04348 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of prominin-like Class Mutagen Stocks Known lesion prominin-likeGD2271 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes prominin-likeKK103090 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2271} NA P{KK103090} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}prominin-likeMI02343 NA PBac{PB}prominin-likec04290 NA PBac{PB}prominin-likec04348 NA PBac{RB}prominin-likee03410 NA PBac{WH}prominin-likef03422 NA insertion of enhancer trap binary system Mi{ET1}prominin-likeMB08636 No Mi{ET1}prominin-likeMB08988 No
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR008795 (FlyBase Curators et al., 2004-) plasma membrane non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions prominin-like allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63870 DroID - A comprehensive database of gene and protein interactions. • FBgn0026189 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38372
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10222 Dere\GG14481 Dmoj\GI12721 Dsec\GM14085 Dvir\GJ12708 Dwil\GK17624 Dyak\GE21669
Curated drosophilid orthologs	Dpse\GA20556
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012561-PA Aedes aegypti (mosquito) AGAP005710-PA Anopheles gambiae (mosquito) XP_001122309.1 Apis mellifera (honey bee) XP_001946597.1 Acyrthosiphon pisum (pea aphid) 124670 Branchiostoma floridae (lancelet) BGIBMGA003937-PA Bombyx mori (silk worm) ENSBTAP00000018252 Bos taurus (bovine) CN14886 Caenorhabditis brenneri (small nematode) CBP04181 Caenorhabditis briggsae (nematode) CE03162 Caenorhabditis elegans (worm) ENSCAFP00000022493 Canis familiaris (dog) JA10423 Caenorhabditis japonica (nematode) CPIJ002145 Culex pipens (mosquito) ENSCPOP00000007064 Cavia porcellus (guinea pig) RP29479 Caenorhabditis remanei (nematode) 199974 Capitella spl (polychaete worm) 95295 Daphnia pulex (daphnia) ENSDARP00000093692 Danio rerio (zebra fish) ENSECAP00000011835 Equus caballus (horse) ENSGACP00000022508 Gymnopilus aculeatus (mushroom) ENSP00000265014 Homo sapiens (human) ISCW017303-PA Ixodes scapularis (deer tick) 156479 Lottia gigantea (owl limpet) ENSMODP00000001179 Monodelphis domestica (gray opossum) ENSMMUP00000035408 Macaca mulatta (rhesus monkey) ENSMUSP00000073751 Mus musculus (house mouse) 209704 Nematostella vectensis (starlet anemone) XP_001607729.1 Nasonia vitripennis (wasp) ENSOANP00000022014 Ornithorynchus anatinus (platypus) ENSORLP00000024936 Oryzias latipes (japanese killifish) PHUM007346-PA Pediculus humanus (human body louse) PP24206 Pristionchus pacificus (nematode) ENSPPYP00000016335 Pongo pygmaeus (orangutan) ENSPTRP00000027438 Pan troglodytes (chimpanzee) ENSRNOP00000055503 Rattus norvegicus (norway rat) XP_001201881.1 Strongylocentrotus purpuratus (purple sea urchin) XP_798860.2 Strongylocentrotus purpuratus (purple sea urchin) 58607 Trichoplax adhaerens (metazoa) XP_973083.1 Tribolium castaneum (red flour beetle) ENSTNIP00000000872 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000015607 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000027047 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000053124 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14174 LH22501 ISCW017303 FBgn0238918 FBgn0219623 FBgn0214675 FBgn0214320 FBgn0199944 FBgn0199943 FBgn0185072 FBgn0169014 FBgn0249676 JGI_V11_95295 FBgn0248807 FBgn0245823 FBgn0080550 FBgn0159871 FBgn0158363 FBgn0158349 FBgn0140172 FBgn0135477 FBgn0135478 FBgn0135476 FBgn0123145 FBgn0123146 FBgn0120594 FBgn0118868 FBgn0118003 FBgn0106740 FBgn0096595 FBgn0087263 CPIJ002145 BGIBMGA003937 ACYPI002821 GB10227 AGAP005710 AAEL015593 AAEL012561 PB21546 PHUM184680 GLEAN_05459
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	26392 w1118; Mi{ET1}prominin-likeMB08636 26424 w1118; Mi{ET1}prominin-likeMB08988 34475 y1 w*; Mi{MIC}prominin-likeMI02343 18653 w1118; PBac{WH}prominin-likef03422/TM6B, Tb1
Harvard	- PBac{PB}prominin-likec04290 - PBac{RB}prominin-likee03410 - PBac{WH}prominin-likef03422
VDRC	v102612 P{KK103090}VIE-260B v51957 w1118; P{GD2271}v51957 v51956 w1118; P{GD2271}v51956/TM3
Genomic Clones ( 1 )
	BACR48E19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 105 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM06505 LD16666 LD23965
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07883 AT09726 AT11475 AT13513 AT17974 AT21139 AT24527 AT25368 AT27981 LP12588 LP20826 RE27106 RE31149 RH50775 RH51516 RH52082 RH68816 RH70986 SD09615 SD10733
Other clones	8056 12451 12634 14317 14644 15100 32119 35946 37765 43554 45938 54497 62418 75235 80572 81173 117890 122752 156298 157107 162977 163172 191078 193950 214349.11 214349.12 214535.20 214543.12 523874 bs29e02 CK01.8A.A4 CK01.52B.C8 CK01.65C.F1 EC051170 EC051681 EC052702 EC053671 EC054159 EC055714 EK006501 EK042344 EK047706 EK049803 EK065860 EK105818 EK113457 EK113942 EK117143 EK117358 EK117812 EK145837 EK155928 EK162353 EK162756 EK174222 EK180712 EK187511 EK191704 EK202904 EK205326 EK212743 EK214619 EK237721 EK246059 EK262143 EK267055 EK267447 EK305806 EN04347 EP05925 EP09233 EP18648 ESG011c.E7_B11 ESG011c.E21_B11 ESG0112b.B21_C01 FGM104H08 FGM211A12 LD22538 RP004109576 RP004134424 RP004364181 RP004458826
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026189 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38372
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: prominin-like CG7740 (Yao, 1999.11)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139513 NM_167986 NM_167987 RefSeq (Proteins) • NP_647770 NP_728809 NP_728810 DDBJ / EMBL / GenBank • AA441662 AA802877 AA817301 AA820383 AAD22487 AAF07212 AAF47716 AAL28872 AAN11530 AAN11531 AAO39605 AF127935 AF197345 AI455409 AI544245 AI946676 AW941267 AY061324 BG638315 BT003602 CZ469140 CZ469201 CZ481188 CZ485986 Entrez Gene - A searchable database of RefSeq genes. • 38372 UniProtKB/Swiss-Prot • P82295
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Prominin (IPR008795)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63870 DroID - A comprehensive database of gene and protein interactions. • FBgn0026189 DRSC - Results from RNAi screens. • FBgn0026189 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026189 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7740-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026189 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38372 InParanoid A subset of ortholog calls from InParanoid. • AAEL012561-PA Aedes aegypti (mosquito) AGAP005710-PA Anopheles gambiae (mosquito) XP_001122309.1 Apis mellifera (honey bee) XP_001946597.1 Acyrthosiphon pisum (pea aphid) 124670 Branchiostoma floridae (lancelet) BGIBMGA003937-PA Bombyx mori (silk worm) ENSBTAP00000018252 Bos taurus (bovine) CN14886 Caenorhabditis brenneri (small nematode) CBP04181 Caenorhabditis briggsae (nematode) CE03162 Caenorhabditis elegans (worm) ENSCAFP00000022493 Canis familiaris (dog) JA10423 Caenorhabditis japonica (nematode) CPIJ002145 Culex pipens (mosquito) ENSCPOP00000007064 Cavia porcellus (guinea pig) RP29479 Caenorhabditis remanei (nematode) 199974 Capitella spl (polychaete worm) 95295 Daphnia pulex (daphnia) ENSDARP00000093692 Danio rerio (zebra fish) ENSECAP00000011835 Equus caballus (horse) ENSGACP00000022508 Gymnopilus aculeatus (mushroom) ENSP00000265014 Homo sapiens (human) ISCW017303-PA Ixodes scapularis (deer tick) 156479 Lottia gigantea (owl limpet) ENSMODP00000001179 Monodelphis domestica (gray opossum) ENSMMUP00000035408 Macaca mulatta (rhesus monkey) ENSMUSP00000073751 Mus musculus (house mouse) 209704 Nematostella vectensis (starlet anemone) XP_001607729.1 Nasonia vitripennis (wasp) ENSOANP00000022014 Ornithorynchus anatinus (platypus) ENSORLP00000024936 Oryzias latipes (japanese killifish) PHUM007346-PA Pediculus humanus (human body louse) PP24206 Pristionchus pacificus (nematode) ENSPPYP00000016335 Pongo pygmaeus (orangutan) ENSPTRP00000027438 Pan troglodytes (chimpanzee) ENSRNOP00000055503 Rattus norvegicus (norway rat) XP_001201881.1 Strongylocentrotus purpuratus (purple sea urchin) XP_798860.2 Strongylocentrotus purpuratus (purple sea urchin) 58607 Trichoplax adhaerens (metazoa) XP_973083.1 Tribolium castaneum (red flour beetle) ENSTNIP00000000872 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000015607 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000027047 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000053124 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38372 modMine - Data generated by the modENCODE project. • FBgn0026189 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14174 LH22501 ISCW017303 FBgn0238918 FBgn0219623 FBgn0214675 FBgn0214320 FBgn0199944 FBgn0199943 FBgn0185072 FBgn0169014 FBgn0249676 JGI_V11_95295 FBgn0248807 FBgn0245823 FBgn0080550 FBgn0159871 FBgn0158363 FBgn0158349 FBgn0140172 FBgn0135477 FBgn0135478 FBgn0135476 FBgn0123145 FBgn0123146 FBgn0120594 FBgn0118868 FBgn0118003 FBgn0106740 FBgn0096595 FBgn0087263 CPIJ002145 BGIBMGA003937 ACYPI002821 GB10227 AGAP005710 AAEL015593 AAEL012561 PB21546 PHUM184680 GLEAN_05459
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	bs29e02.y1 (Andrews et al., 2000) CG7740 (Whitfield, 2000.5.4, Keleman et al., 2009.8.5) prominin-like (Dorus et al., 2006, Sepp et al., 2008, Vinci et al., 2008, Wasbrough et al., 2010)
Name Synonym	prominin-like   Prominin-like (Sepp et al., 2008) prominin-like protein (Corbeil, 1999.2.12)
Secondary FlyBase IDs
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 4 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 8 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...